Anthony Steven Grillo

Group Website
www.GrilloLabUC.com

Anthony Grillo joined the University of Cincinnati in the Department of Chemistry as an Assistant Professor in 2022 with research interests in understanding the molecular underpinnings of the role of mitochondrial dysfunction in disease with an emphasis on micronutrient (e.g. metals, oxygen, vitamins, etc.) metabolism.

Dr. Grillo obtained a B.S. in Biochemistry and B.S. in Chemistry from the University of Michigan in 2011. He obtained his Ph.D. in Chemistry (Organic Chemistry focus) in 2017 at the University of Illinois at Urbana-Champaign under the mentorship of Martin Burke as an NSF predoctoral fellow (NSF GRFP). His thesis centered on the discovery, development, and mechanistic understanding of small molecules that mimic protein function to restore physiology to organisms missing iron transport proteins, thereby acting as prostheses on the molecular scale. As an NRSA postdoctoral fellow and Alzheimer's Disease Research Center Trainee in Matt Kaeberlein's Lab at the University of Washington, Dr. Grillo elucidated the mechanistic role of protein kinace C in promoting neuroinflammation in mitochondrial disease mice and the influence of iron status on disease progression.

Dr. Grillo's background in biochemistry, chemical biology, and metabolic physiology make him excited to perform interdisciplinary research centered on revealing how mitochondrial dysfunction alters micronutrient metabolism (e.g. metals, oxygen, vitamins, etc.) to elicit neurodegeneration in age-related, genetic, or environmental-induced disease in multiple in vitro and in vivo models.

Ph.D. Chemistry: University of Illinois at Urbana-Champaign 2017 (Organic Chemistry)

B.S. Chemistry: University of Michigan 2011

B.S. Biochemistry: University of Michigan 2011

The Grillo Lab's interests include:

     1) Elucidating the etiology of mitochondrial Complex I deficiencies and oxygen dyshomeostasis in neurodegeneration.
     2) Uncovering the role of transition metals in age-related diseases.
     3) Discovering novel interventions to treat mitochondrial inborn errors of metabolism.

2018 -2022 Senior Fellow, Postdoctorate Researcher in the Kaeberlein Lab., University of Washington, Seattle, WA

2022 - Assistant Professor, University of Cincinnati, Cincinnati, OH

2023 - Neuroscience Graduate Program Faculty - Obesity & Metabolism Division,

2023 - Center for Environmental Genetics - Associate Member,

Grant: #PI-23-0026 Investigators:Grillo, Anthony 09-01-2023 -08-31-2025 United Mitochondrial Disease Foundation United Mitochondrial Disease Foundation Grant - https://umdf.smapply.org/prog/2023_principal_investigator_grant/ Role:PI 58750.00 Hold Level:Non Profit

Grant: #1R01AG084718 - 01 Investigators:Grillo, Anthony; Vest, Katherine 04-01-2024 -08-31-2028 National Institute on Aging Probing the tissue-specific mechanisms and therapeutic potential of mTOR inhibition in branched chain amino acid-related diseases. Role:PI 0.00 Hold Level:Federal

Grant: #R01AG084718-01 Investigators:Grillo, Anthony; Vest, Katherine 04-01-2024 -08-31-2028 National Institute on Aging Probing the tissue-specific mechanisms and therapeutic potential of mTOR inhibition in branched chain amino acid-related diseases. Role:PI 233761.00 Hold Level:Federal

Book Chapter

Peer Reviewed Publications

Acarbose Suppresses Symptoms of Mitochondrial Disease in a Mouse Model of Leigh Syndrome
Bitto, A.; Grillo, A.S., Ito, S.K.; Stanaway, I.; Nguyen, B.; Ying, K.; Tung, H.; Smith, K.; Tran, N.; Velikanje, G.; Urfer, S.; Snyder, J.; Barton, J.; Sharma, A.; Kayser, E.-B.; Wang, L.; Smith, D.; Thompson, J.W.; DuBois, L.; DePaolo, W.; Kaeberlein, M. Nat. Metab. 2023. 5, 955-967.

 Iron Status Influences Mitochondrial Disease Progression in Complex I-Deficient Mice
Kelly, C.; Couch, R.K.; Ha, V.T.; Bodart, C.M.; Wu, J.; Huff, S.; Herrel, N.T.; Kim, H.D.; Zimmermann, A.O.; Shattuck, J.; Pan, Y.-C.; Kaeberlein, M.*; Grillo, A.S.* eLife 2023, 12, e75825.

Invited Presentations

AS Grillo (03-28-2023. ) Iron Status Influences Mitochondrial Disease Progression in Complex I-Deficient Mice .University of Cincinnati - Department of Biochemistry and Molecular Genetics. UC. . Level:University

AS Grillo (04-21-2023. ) Iron Status Influences Mitochondrial Disease Progression in Complex I-Deficient Mice .Cleveland State Department of Chemistry, Cleveland, OH. Other Institution. . Level:State

AS Grillo (06-01-2023. ) A Mitochondrial Complex I Deficiency Induces Iron Accumulation and Tau Aggregation .Seattle, WA. Other Institution. . Level:National

AS Grillo (10-26-2023. ) A Mitochondrial Complex I Deficiency Induces Iron Accumulation and Tau Aggregation .University of Cincinnati - Neuroscience Graduate Program. Level:National

Poster Presentations

AS Grillo (06-08-2023. ) A Complex I Deficiency Induces Tau Misregulation in Mitochondrial Disease .American Aging Association National Meeting, Oklahoma City, OK. . Professional Meeting. . Level:National

2022 OEPT Training Workshop

2022 Graduate Admissions Committee

2022 Diversity, Equity, and Inclusion Taskforce

2023 Global Research Experience in Chemistry Program

(2023 Co-Lead, UC ACS SEED Program for High School Students )

(2023 Students without Borders - Co-Lead )

(2023 OEPT Training Workshop - Director )

2023 Recruiting Committee

(2024 Research Advisory Committee )

(2024 Students without Borders - Director )

2022 CHEM 8039: Transition Metals in Biochemistry, Biology, and Medicine

-CHEM-2030 SURVEY BIOCHEM I Level:Undergraduate

-CHEM-3040 INTRO BIOCHEM Level:Undergraduate

2024 CHEM 5021 - Literature Undergraduate Research (Bordeaux)

Academic - Phone: 5135561034
grilloas@ucmail.uc.edu