Sean Davidson

Sean Davidson

Professor, Vice Chair of Research

Education

Bachelor of Science, Indiana University Bloomington, IN, 1990 (Biochemistry, Minor in Biology)

Post Doctoral Fellowship, University of Illinois Urbana, IL, 1997 ("The domain structure of apolipoprotein A-1")

Doctorate, The Medical College of Pennsylvania (Drexel University) Philadelphia, PA, 1994 (BioChemistry, "High density lipoprotein composition and cellular cholesterol efflux")

Positions and Work Experience

- Professor, Department of Pathology and Laboratory Medicine, Metabolic Disease Institute Cincinnati - GRIA 267

Research and Practice Interests

The overall aim of the lab is to understand the mechanisms by which the body protects itself from heart disease. We use mutagenesis and spectroscopic techniques to study the structure/function relationships of the proteins that comprise high density lipoproteins. 

For more information, please visit the lab's website at:
http://homepages.uc.edu/~davidswm/Labpage.html

Publications

Peer Reviewed Publications

Basford, Joshua E; Wancata, Lauren; Hofmann, Susanna M; Silva, R A Gangani D; Davidson, W Sean; Howles, Philip N; Hui, David Y (2011. ) Hepatic Deficiency of Low Density Lipoprotein Receptor-related Protein-1 Reduces High Density Lipoprotein Secretion and Plasma Levels in Mice.The Journal of biological chemistry, , 286 (15 ) ,13079-87

Huang, Rong; Silva, R A Gangani D; Jerome, W Gray; Kontush, Anatol; Chapman, M John; Curtiss, Linda K; Hodges, Timothy J; Davidson, W Sean (2011. ) Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma.Nature structural & molecular biology, , 18 (4 ) ,416-22

Gordon, Scott M; Hofmann, Susanna; Askew, David S; Davidson, W Sean (2011. ) High density lipoprotein: it's not just about lipid transport anymore.Trends in endocrinology and metabolism: TEM, , 22 (1 ) ,9-15

Davidson, W Sean; Silva, R A Gangani D; Chantepie, Sandrine; Lagor, William R; Chapman, M John; Kontush, Anatol (2009. ) Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function.Arteriosclerosis, thrombosis, and vascular biology, , 29 (6 ) ,870-6

Silva, R A Gangani D; Hilliard, George M; Li, Ling; Segrest, Jere P; Davidson, W Sean (2005. ) A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins.Biochemistry, , 44 (24 ) ,8600-7

Panagotopulos, Stacey E; Witting, Scott R; Horace, Erica M; Hui, David Y; Maiorano, J Nicholas; Davidson, W Sean (2002. ) The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1.The Journal of biological chemistry, , 277 (42 ) ,39477-84

Maiorano, J N; Davidson, W S (2000. ) The orientation of helix 4 in apolipoprotein A-I-containing reconstituted high density lipoproteins.The Journal of biological chemistry, , 275 (23 ) ,17374-80

Davidson, W S; Arnvig-McGuire, K; Kennedy, A; Kosman, J; Hazlett, T L; Jonas, A (1999. ) Structural organization of the N-terminal domain of apolipoprotein A-I: studies of tryptophan mutants .Biochemistry, , 38 (43 ) ,14387-95

Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C (1998. ) Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization .Journal of lipid research, , 39 (10 ) ,1918-28

Davidson, W S; Lund-Katz, S; Johnson, W J; Anantharamaiah, G M; Palgunachari, M N; Segrest, J P; Rothblat, G H; Phillips, M C (1994. ) The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein .The Journal of biological chemistry, , 269 (37 ) ,22975-82

Davidson, W S; Sparks, D L; Lund-Katz, S; Phillips, M C (1994. ) The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins .The Journal of biological chemistry, , 269 (12 ) ,8959-65

Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C (1993. ) Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles .The Journal of biological chemistry, , 268 (31 ) ,23250-7

Gordon, Scott M; Deng, Jingyuan; Lu, L Jason; Davidson, W Sean (2010. ) Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography.Journal of proteome research, , 9 (10 ) ,5239-49

Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min (2010. ) Estradiol increases the anorectic effect of central apolipoprotein A-IV.Endocrinology, , 151 (7 ) ,3163-8

Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H (2010. ) Melanocortin signaling in the CNS directly regulates circulating cholesterol.Nature neuroscience, , 13 (7 ) ,877-82

Smith, Loren E; Davidson, W Sean (2010. ) The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux.Biochimica et biophysica acta, , 1801 (1 ) ,64-9

Jenkins, Katie T; Merkens, Louise S; Tubb, Matthew R; Myatt, Leslie; Davidson, W Sean; Steiner, Robert D; Woollett, Laura A (2008. ) Enhanced placental cholesterol efflux by fetal HDL in Smith-Lemli-Opitz syndrome.Molecular genetics and metabolism, , 94 (2 ) ,240-7

Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2007. ) Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 293 (4 ) ,R1490-4

Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean (2007. ) Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini.The Journal of biological chemistry, , 282 (39 ) ,28385-94

Vedhachalam, Charulatha; Ghering, Amy B; Davidson, W Sean; Lund-Katz, Sissel; Rothblat, George H; Phillips, Michael C (2007. ) ABCA1-induced cell surface binding sites for ApoA-I.Arteriosclerosis, thrombosis, and vascular biology, , 27 (7 ) ,1603-9

Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min (2007. ) Hypothalamic apolipoprotein A-IV is regulated by leptin.Endocrinology, , 148 (6 ) ,2681-9

Silva, R A Gangani D; Schneeweis, Lumelle A; Krishnan, Srinivasan C; Zhang, Xiuqi; Axelsen, Paul H; Davidson, W Sean (2007. ) The structure of apolipoprotein A-II in discoidal high density lipoproteins.The Journal of biological chemistry, , 282 (13 ) ,9713-21

Melchior, John T; Street, Scott E; Andraski, Allison B; Furtado, Jeremy D; Sacks, Frank M; Shute, Rebecca L; Greve, Emily I; Swertfeger, Debi K; Li, Hailong; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2017. ) Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1.Journal of lipid research, ,

Rueda, Cesar M; Rodriguez-Perea, Ana Lucia; Moreno-Fernandez, Maria; Jackson, Courtney M; Melchior, John T; Davidson, W Sean; Chougnet, Claire A (2017. ) High Density Lipoproteins Selectively Promote the Survival of Human Regulatory T-cells.Journal of lipid research, ,

Swertfeger, Debi K; Li, Hailong; Rebholz, Sandra; Zhu, Xiaoting; Shah, Amy S; Davidson, W Sean; Lu, Long J (2017. ) Mapping Atheroprotective Functions and Related Proteins/Lipoproteins in Size Fractionated Human Plasma.Molecular & cellular proteomics : MCP, , 16 (4 ) ,680-693

Kodvawala, Ahmer; Ghering, Amy B; Davidson, W Sean; Hui, David Y (2005. ) Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis.The Journal of biological chemistry, , 280 (46 ) ,38592-8

Davidson, W S; Inge, T H; Sexmith, H; Heink, A; Elder, D; Hui, D Y; Melchior, J T; Kelesidis, T; Shah, A S (2017. ) Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function.International journal of obesity (2005), , 41 (1 ) ,83-89

Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean (2005. ) Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association.The Journal of biological chemistry, , 280 (46 ) ,38576-82

Basford, Joshua E; Wancata, Lauren; Hofmann, Susanna M; Silva, R A Gangani D; Davidson, W Sean; Howles, Philip N; Hui, David Y (2011. ) Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice.The Journal of biological chemistry, , 286 (15 ) ,13079-87

Huang, Rong; Silva, R A Gangani D; Jerome, W Gray; Kontush, Anatol; Chapman, M John; Curtiss, Linda K; Hodges, Timothy J; Davidson, W Sean (2011. ) Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma.Nature structural & molecular biology, , 18 (4 ) ,416-22

Davidson, W Sean; Silva, R A Gangani D (2005. ) Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins .Current opinion in lipidology, , 16 (3 ) ,295-300

Gordon, Scott M; Hofmann, Susanna; Askew, David S; Davidson, W Sean (2011. ) High density lipoprotein: it's not just about lipid transport anymore.Trends in endocrinology and metabolism: TEM, , 22 (1 ) ,9-15

Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean (2005. ) Bacterial expression and characterization of rat apolipoprotein E.Protein expression and purification, , 41 (2 ) ,447-53

Gordon, Scott M; Deng, Jingyuan; Lu, L Jason; Davidson, W Sean (2010. ) Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography.Journal of proteome research, , 9 (10 ) ,5239-49

Silva, R A Gangani D; Hilliard, George M; Fang, Jianwen; Macha, Stephen; Davidson, W Sean (2005. ) A three-dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading.Biochemistry, , 44 (8 ) ,2759-69

Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min (2010. ) Estradiol increases the anorectic effect of central apolipoprotein A-IV.Endocrinology, , 151 (7 ) ,3163-8

Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H (2010. ) Melanocortin signaling in the CNS directly regulates circulating cholesterol.Nature neuroscience, , 13 (7 ) ,877-82

Smith, Loren E; Davidson, W Sean (2010. ) The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux.Biochimica et biophysica acta, , 1801 (1 ) ,64-9

Gordon, Scott; Durairaj, Anita; Lu, Jason L; Davidson, W Sean (2010. ) High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality.Current cardiovascular risk reports, , 4 (1 ) ,1-8

Davidson, W Sean; Silva, R A Gangani D; Chantepie, Sandrine; Lagor, William R; Chapman, M John; Kontush, Anatol (2009. ) Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function.Arteriosclerosis, thrombosis, and vascular biology, , 29 (6 ) ,870-6

Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean (2008. ) An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages.Journal of lipid research, , 49 (6 ) ,1322-32

Jenkins, Katie T; Merkens, Louise S; Tubb, Matthew R; Myatt, Leslie; Davidson, W Sean; Steiner, Robert D; Woollett, Laura A (2008. ) Enhanced placental cholesterol efflux by fetal HDL in Smith-Lemli-Opitz syndrome.Molecular genetics and metabolism, , 94 (2 ) ,240-7

Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A (2003. ) Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation.Journal of lipid research, , 44 (10 ) ,1909-18

Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2007. ) Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 293 (4 ) ,R1490-4

Davidson, W Sean; Hilliard, George M (2003. ) The spatial organization of apolipoprotein A-I on the edge of discoidal high density lipoprotein particles: a mass specrometry study.The Journal of biological chemistry, , 278 (29 ) ,27199-207

Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean (2007. ) Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini.The Journal of biological chemistry, , 282 (39 ) ,28385-94

Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick (2003. ) Expression of biologically active rat apolipoprotein AIV in Escherichia coli .Physiology & behavior, , 78 (1 ) ,149-55

Vedhachalam, Charulatha; Ghering, Amy B; Davidson, W Sean; Lund-Katz, Sissel; Rothblat, George H; Phillips, Michael C (2007. ) ABCA1-induced cell surface binding sites for ApoA-I.Arteriosclerosis, thrombosis, and vascular biology, , 27 (7 ) ,1603-9

Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min (2007. ) Hypothalamic apolipoprotein A-IV is regulated by leptin.Endocrinology, , 148 (6 ) ,2681-9

Reschly, Erica J; Sorci-Thomas, Mary G; Davidson, W Sean; Meredith, Stephen C; Reardon, Catherine A; Getz, Godfrey S (2002. ) Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution.The Journal of biological chemistry, , 277 (12 ) ,9645-54

Silva, R A Gangani D; Schneeweis, Lumelle A; Krishnan, Srinivasan C; Zhang, Xiuqi; Axelsen, Paul H; Davidson, W Sean (2007. ) The structure of apolipoprotein A-II in discoidal high density lipoproteins.The Journal of biological chemistry, , 282 (13 ) ,9713-21

Kodvawala, Ahmer; Ghering, Amy B; Davidson, W Sean; Hui, David Y (2005. ) Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis.The Journal of biological chemistry, , 280 (46 ) ,38592-8

Safi, W; Maiorano, J N; Davidson, W S (2001. ) A proteolytic method for distinguishing between lipid-free and lipid-bound apolipoprotein A-I .Journal of lipid research, , 42 (5 ) ,864-72

Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean (2005. ) Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association.The Journal of biological chemistry, , 280 (46 ) ,38576-82

Silva, R A Gangani D; Hilliard, George M; Li, Ling; Segrest, Jere P; Davidson, W Sean (2005. ) A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins.Biochemistry, , 44 (24 ) ,8600-7

Davidson, W Sean; Silva, R A Gangani D (2005. ) Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins. Current opinion in lipidology, , 16 (3 ) ,295-300

Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean (2005. ) Bacterial expression and characterization of rat apolipoprotein E.Protein expression and purification, , 41 (2 ) ,447-53

Silva, R A Gangani D; Hilliard, George M; Fang, Jianwen; Macha, Stephen; Davidson, W Sean (2005. ) A three-dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading.Biochemistry, , 44 (8 ) ,2759-69

Davidson, W Sean; Hilliard, George M (2003. ) The spatial organization of apolipoprotein A-I on the edge of discoidal high density lipoprotein particles: a mass specrometry study.The Journal of biological chemistry, , 278 (29 ) ,27199-207

Lund-Katz, S; Murley, Y M; Yon, E; Gillotte, K L; Davidson, W S (1996. ) Comparison of the structural and functional effects of monomeric and dimeric human apolipoprotein A-II in high density lipoprotein particles .Lipids, , 31 (11 ) ,1107-13

Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick (2003. ) Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, , 78 (1 ) ,149-55

Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C (1996. ) Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux .The Journal of biological chemistry, , 271 (39 ) ,23792-8

Panagotopulos, Stacey E; Witting, Scott R; Horace, Erica M; Hui, David Y; Maiorano, J Nicholas; Davidson, W Sean (2002. ) The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1.The Journal of biological chemistry, , 277 (42 ) ,39477-84

Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C (1995. ) Effects of the neutral lipid content of high density lipoprotein on apolipoprotein A-I structure and particle stability .The Journal of biological chemistry, , 270 (45 ) ,26910-7

Reschly, Erica J; Sorci-Thomas, Mary G; Davidson, W Sean; Meredith, Stephen C; Reardon, Catherine A; Getz, Godfrey S (2002. ) Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution.The Journal of biological chemistry, , 277 (12 ) ,9645-54

Safi, W; Maiorano, J N; Davidson, W S (2001. ) A proteolytic method for distinguishing between lipid-free and lipid-bound apolipoprotein A-I. Journal of lipid research, , 42 (5 ) ,864-72

Maiorano, J N; Davidson, W S (2000. ) The orientation of helix 4 in apolipoprotein A-I-containing reconstituted high density lipoproteins.The Journal of biological chemistry, , 275 (23 ) ,17374-80

Davidson, W S; Arnvig-McGuire, K; Kennedy, A; Kosman, J; Hazlett, T L; Jonas, A (1999. ) Structural organization of the N-terminal domain of apolipoprotein A-I: studies of tryptophan mutants. Biochemistry, , 38 (43 ) ,14387-95

Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C (1998. ) Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization. Journal of lipid research, , 39 (10 ) ,1918-28

Lund-Katz, S; Murley, Y M; Yon, E; Gillotte, K L; Davidson, W S (1996. ) Comparison of the structural and functional effects of monomeric and dimeric human apolipoprotein A-II in high density lipoprotein particles. Lipids, , 31 (11 ) ,1107-13

Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C (1996. ) Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux. The Journal of biological chemistry, , 271 (39 ) ,23792-8

McLean, L R; Hagaman, K A; Davidson, W S (1993. ) Role of lipid structure in the activation of phospholipase A2 by peroxidized phospholipids .Lipids, , 28 (6 ) ,505-9

Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C (1995. ) Effects of the neutral lipid content of high density lipoprotein on apolipoprotein A-I structure and particle stability. The Journal of biological chemistry, , 270 (45 ) ,26910-7

Davidson, W S; Lund-Katz, S; Johnson, W J; Anantharamaiah, G M; Palgunachari, M N; Segrest, J P; Rothblat, G H; Phillips, M C (1994. ) The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. The Journal of biological chemistry, , 269 (37 ) ,22975-82

Davidson, W S; Sparks, D L; Lund-Katz, S; Phillips, M C (1994. ) The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins. The Journal of biological chemistry, , 269 (12 ) ,8959-65

Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C (1993. ) Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles. The Journal of biological chemistry, , 268 (31 ) ,23250-7

McLean, L R; Hagaman, K A; Davidson, W S (1993. ) Role of lipid structure in the activation of phospholipase A2 by peroxidized phospholipids. Lipids, , 28 (6 ) ,505-9

Rebholz, Sandra L; Melchior, John T; Davidson, W Sean; Jones, Helen N; Welge, Jeffrey A; Prentice, Andrew M; Moore, Sophie E; Woollett, Laura A (2017. ) Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,

Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Dolan, Lawrence M; Gordon, Scott M; Otvos, James D; Melchior, John T; Elder, Deborah A; Khoury, Jane; Geh, Esmond; Shah, Amy S (2017. ) Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease.Journal of lipid research, , 58 (9 ) ,1916-1923

Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu (2018. ) Apolipoprotein A-IV binds ?IIb?3 integrin and inhibits thrombosis.Nature communications, , 9 (1 ) ,3608

von Schalburg, Kristian R; Rondeau, Eric B; Leong, Jong S; Davidson, William S; Koop, Ben F (2018. ) Regulatory processes that control haploid expression of salmon sperm mRNAs.BMC research notes, , 11 (1 ) ,639

Cooke, Allison L; Morris, Jamie; Melchior, John T; Street, Scott E; Jerome, W Gray; Huang, Rong; Herr, Andrew B; Smith, Loren E; Segrest, Jere P; Remaley, Alan T; Shah, Amy S; Thompson, Thomas B; Davidson, W Sean (2018. ) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.Journal of lipid research, , 59 (7 ) ,1244-1255

Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min (2009. ) Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats.Physiology & behavior, , 98 (1-2 ) ,223-8

Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang (2018. ) Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.Nature communications, , 9 (1 ) ,700

Tubb, Matthew R; Smith, Loren E; Davidson, W Sean (2009. ) Purification of recombinant apolipoproteins A-I and A-IV and efficient affinity tag cleavage by tobacco etch virus protease.Journal of lipid research, , 50 (7 ) ,1497-504

Swertfeger, Debi K; Rebholz, Sandra; Li, Hailong; Shah, Amy S; Davidson, William Sean; Lu, Long J Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins.Journal of clinical lipidology, , 12 (6 ) ,1539-1548

Melchior, John T; Walker, Ryan G; Cooke, Allison L; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B; Jones, Martin K; Song, Hyun D; Rye, Kerry-Anne; Oda, Michael N; Sorci-Thomas, Mary G; Thomas, Michael J; Heinecke, Jay W; Mei, Xiaohu; Atkinson, David; Segrest, Jere P; Lund-Katz, Sissel; Phillips, Michael C; Davidson, W Sean (2017. ) A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state.Nature structural & molecular biology, , 24 (12 ) ,1093-1099

Sethi, Amar A; Stonik, John A; Thomas, Fairwell; Demosky, Steve J; Amar, Marcelo; Neufeld, Edward; Brewer, H Bryan; Davidson, W Sean; D (2008. ) Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides.The Journal of biological chemistry, , 283 (47 ) ,32273-82

Rebholz, Sandra L; Melchior, John T; Welge, Jeffrey A; Remaley, Alan T; Davidson, W Sean; Woollett, Laura A (2017. ) Effects of Multiple Freeze/Thaw Cycles on Measurements of Potential Novel Biomarkers Associated With Adverse Pregnancy Outcomes.Journal of clinical and laboratory medicine, , 2 (1 ) ,

Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min (2008. ) Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis.Physiology & behavior, , 95 (1-2 ) ,161-7

Silva, R A Gangani D; Huang, Rong; Morris, Jamie; Fang, Jianwen; Gracheva, Elena O; Ren, Gang; Kontush, Anatol; Jerome, W Gray; Rye, Kerry-Anne; Davidson, W Sean (2008. ) Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes.Proceedings of the National Academy of Sciences of the United States of America, , 105 (34 ) ,12176-81

Tubb, Matthew R; Silva, R A Gangani D; Fang, Jianwen; Tso, Patrick; Davidson, W Sean (2008. ) A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry.The Journal of biological chemistry, , 283 (25 ) ,17314-23

Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean (2008. ) An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages.Journal of lipid research, , 49 (6 ) ,1322-32

Oram, John F; Wolfbauer, Gertrud; Tang, Chongren; Davidson, W Sean; Albers, John J (2008. ) An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.The Journal of biological chemistry, , 283 (17 ) ,11541-9

Ghering, Amy B; Davidson, W Sean (2006. ) Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.Journal of lipid research, , 47 (12 ) ,2781-8

Davidson, W Sean; Ghering, Amy B; Beish, Lauren; Tubb, Matthew R; Hui, David Y; Pearson, Kevin (2006. ) The biotin-capture lipid affinity assay: a rapid method for determining lipid binding parameters for apolipoproteins.Journal of lipid research, , 47 (2 ) ,440-9

Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D (2006. ) Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 290 (1 ) ,R202-7

Maiorano, J Nicholas; Jandacek, Ronald J; Horace, Erica M; Davidson, W Sean (2004. ) Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size.Biochemistry, , 43 (37 ) ,11717-26

Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean (2004. ) Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications.Biochemistry, , 43 (33 ) ,10719-29

Davidson, W Sean (2004. ) 5th Annual International Conference on HDL Cholesterol: metabolic pathways and drug developments.Expert opinion on therapeutic targets, , 8 (4 ) ,359-66

Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J (2004. ) Apolipoprotein A-IV inhibits experimental colitis.The Journal of clinical investigation, , 114 (2 ) ,260-9

Narayanaswami, Vasanthy; Maiorano, J Nicholas; Dhanasekaran, Padmaja; Ryan, Robert O; Phillips, Michael C; Lund-Katz, Sissel; Davidson, W Sean (2004. ) Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles.The Journal of biological chemistry, , 279 (14 ) ,14273-9

Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean (2003. ) Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.The Journal of biological chemistry, , 278 (41 ) ,40121-7

Panagotopulos, S E; Horace, E M; Maiorano, J N; Davidson, W S (2001. ) Apolipoprotein A-I adopts a belt-like orientation in reconstituted high density lipoproteins.The Journal of biological chemistry, , 276 (46 ) ,42965-70

Davidson, W S; Jonas, A; Clayton, D F; George, J M (1998. ) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes .The Journal of biological chemistry, , 273 (16 ) ,9443-9

Davidson, W S; Hazlett, T; Mantulin, W W; Jonas, A (1996. ) The role of apolipoprotein AI domains in lipid binding .Proceedings of the National Academy of Sciences of the United States of America, , 93 (24 ) ,13605-10

Davidson, W S; Rodrigueza, W V; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C (1995. ) Effects of acceptor particle size on the efflux of cellular free cholesterol .The Journal of biological chemistry, , 270 (29 ) ,17106-113

Bruce, C; Davidson, W S; Kussie, P; Lund-Katz, S; Phillips, M C; Ghosh, R; Tall, A R (1995. ) Molecular determinants of plasma cholesteryl ester transfer protein binding to high density lipoproteins .The Journal of biological chemistry, , 270 (19 ) ,11532-42

Davidson, W S; Gillotte, K L; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C (1995. ) The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol .The Journal of biological chemistry, , 270 (11 ) ,5882-90

McLean, L R; Hagaman, K A; Owen, T J; Payne, M H; Davidson, W S; Krstenansky, J L (1991. ) Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine .Biochimica et biophysica acta, , 1086 (1 ) ,106-14

Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick (2009. ) Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration.American journal of physiology. Regulatory, integrative and comparative physiology, , 296 (1 ) ,R43-50

Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2016. ) Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome.Journal of proteomics, ,

Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick (2015. ) Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.PloS one, , 10 (11 ) ,e0142098

Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C (2014. ) Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats.Endocrinology, , 155 (5 ) ,1700-7

Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean (2014. ) The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering.The Journal of biological chemistry, , 289 (9 ) ,5596-608

Wang, Fei; Pearson, Kevin J; Davidson, W Sean; Tso, Patrick (2013. ) Specific sequences in N termini of apolipoprotein A-IV modulate its anorectic effect.Physiology & behavior, , 120 ,136-42

Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B (2012. ) The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.Structure (London, England : 1993), , 20 (5 ) ,767-79

Walsh, Kyle B; Hart, Kimberly; Roll, Susan; Sperling, Matthew; Unruh, Dusten; Davidson, W Sean; Lindsell, Christopher J; Adeoye, Opeolu (2016. ) Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , 25 (6 ) ,1360-5

Shah, Amy S; Davidson, W Sean; Gao, Zhiqian; Dolan, Lawrence M; Kimball, Thomas R; Urbina, Elaine M Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without prediabetes.Journal of clinical lipidology, , 10 (3 ) ,610-8

Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Melchior, John T; Gordon, Scott M; Kuklenyik, Zsuzsanna; Woollett, Laura; Barr, John R; Jones, Jeffrey I; Toth, Christopher A; Shah, Amy S (2016. ) The effects of apolipoprotein B depletion on HDL subspecies composition and function.Journal of lipid research, , 57 (4 ) ,674-86

Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y (2015. ) Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis.Circulation, , 132 (20 ) ,1898-908

Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason (2015. ) Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes.Journal of proteome research, , 14 (8 ) ,3082-94

Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S (2015. ) A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry.Journal of proteome research, , 14 (7 ) ,2943-50

Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2015. ) A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins.Journal of proteome research, , 14 (6 ) ,2686-95

Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B (2015. ) Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function.The Journal of biological chemistry, , 290 (17 ) ,10689-702

Niesor, Eric J; Gauthamadasa, Kekulawalage; Silva, R A Gangani D; Suchankova, Gabriela; Kallend, David; Gylling, Helena; Asztalos, Bela; Damonte, Elisabetta; Rossomanno, Simona; Abt, Markus; Davidson, W Sean; Benghozi, Renee (2013. ) Xanthophylls, phytosterols and pre-?1-HDL are differentially affected by fenofibrate and niacin HDL-raising in a cross-over study.Lipids, , 48 (12 ) ,1185-96

Lehti, Maarit; Donelan, Elizabeth; Abplanalp, William; Al-Massadi, Omar; Habegger, Kirk M; Weber, Jon; Ress, Chandler; Mansfeld, Johannes; Somvanshi, Sonal; Trivedi, Chitrang; Keuper, Michaela; Ograjsek, Teja; Striese, Cynthia; Cucuruz, Sebastian; Pfluger, Paul T; Krishna, Radhakrishna; Gordon, Scott M; Silva, R A Gangani D; Luquet, Serge; Castel, Julien; Martinez, Sarah; D'Alessio, David; Davidson, W Sean; Hofmann, Susanna M (2013. ) High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.Circulation, , 128 (22 ) ,2364-71

Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S (2013. ) The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth.Diabetes, , 62 (8 ) ,2958-67

Smith, Loren E; Segrest, Jere P; Davidson, W Sean (2013. ) Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II.Journal of lipid research, , 54 (7 ) ,1939-48

Nguyen, Andrew D; Nguyen, Thi A; Cenik, Basar; Yu, Gang; Herz, Joachim; Walther, Tobias C; Davidson, W Sean; Farese, Robert V (2013. ) Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).The Journal of biological chemistry, , 288 (12 ) ,8627-35

Smith, Loren E; Yang, Jun; Goodman, Leah; Huang, Xinqi; Huang, Rong; Dressman, James; Morris, Jamie; Silva, R A Gangani D; Davidson, W Sean; Cavigiolio, Giorgio (2012. ) High yield expression and purification of recombinant human apolipoprotein A-II in Escherichia coli.Journal of lipid research, , 53 (8 ) ,1708-15

Wang, Fei; Kohan, Alison B; Kindel, Tammy L; Corbin, Kathryn L; Nunemaker, Craig S; Obici, Silvana; Woods, Stephen C; Davidson, W Sean; Tso, Patrick (2012. ) Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.Proceedings of the National Academy of Sciences of the United States of America, , 109 (24 ) ,9641-6

Deng, Xiaodi; Davidson, W Sean; Thompson, Thomas B (2012. ) Improving the diffraction of apoA-IV crystals through extreme dehydration.Acta crystallographica. Section F, Structural biology and crystallization communications, , 68 (Pt 1 ) ,105-10

Mythreye, Karthikeyan; Satterwhite, Lisa L; Davidson, W Sean; Goldschmidt-Clermont, Pascal J ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair.Biochimica et biophysica acta, , 1781 (11-12 ) ,703-9

Contact Information

Research - Metabolic Diseases Institute
2120 Galbraith Road
Reading  Ohio, 45215
Phone: (513) 558-3707
sean.davidson@uc.edu