Deeptankar DeMazumder

Deeptankar DeMazumder

Asst Professor - Geo

Medical Sciences Building

COM IM Cardiology B - 0542

Office
231 Albert Sabin Way, CVC 3923
Cincinnati, Ohio 45267-0542

Professional Summary

     Dr. DeMazumder is a physician-scientist in cardiac electrophysiology (EP). His clinical expertise includes the diagnosis, treatment and prevention of cardiac arrhythmias using cutting-edge approaches, with a particular emphasis on the potentially lethal ventricular arrhythmias and conduction disorders responsible for sudden death. This has remained the focus of Dr. DeMazumder's studies since high school.

     More people continue to die suddenly each year (as many as 7 million worldwide) than all other disease-related causes of death combined. The link between the autonomic nervous system, oxidative stress, heart failure and sudden cardiac death is quite strong. The underlying mechanisms remain unclear, hampering development of new, more effective therapies. Using innovative approaches, Dr. DeMazumder's research is aimed at understanding this link in the context of patho/physiological mechanisms, clinically-relevant animal models, novel biosensors, “big data” predictive analytics, and clinical trials.

     In this context, Dr. DeMazumder's wet lab employs a variety of in vitro (e.g. patch clamping, fluorescence microscopy, biochemical), ex vivo (e.g., Langendorff-based EP studies), in vivo (e.g., catheter-based EP studies), genetic (e.g., CRISPR/Cas9, in vivo gene transfer), and systemic (e.g., nonlinear dynamics, numerical analysis) approaches to study nerve-myocyte signaling, subcellular oxidative stress, intracellular calcium handling, and ion channel biophysics. His dry lab uses a combination of high performance computing and novel machine and "deep" learning algorithms (some of which were developed by Dr. DeMazumder) to identify "hidden" signatures of brewing critical illness in patients with moderate or advanced disease, as well as in asymptomatic community-based individuals with little or no known disease. These subclinical signatures may be indistinguishable in conventional clinical diagnostics but can be detected using readily available methods in clinical (e.g., ICU, hospital wards, sleep studies) and ambulatory (e.g., implantable devices, "smart" wearables, home) settings.

     As a practicing cardiac EP physician, basic scientist and clinical trialist, Dr. DeMazumder’s efforts are aimed at coming “full circle” from bench to the bedside, i.e., by transforming clinical observations into testable research hypotheses, translating basic research findings into medical advances, and designing and evaluating patient treatment protocols in rigorous clinical trials. His curricula vitae are aimed at advancing the quality of life for many, while still being able to care for individuals.

Education

B.Sc., SUNY Stony Brook NY, (Biochemistry Cybernetics)

Ph.D., SUNY Stony Brook NY, (Biophysics (Synaptic Electrophysiology))

M.D., Virginia Commonwealth University - Medical College of Virginia VA, (Doctor of Medicine)

High School Scholars, New York University School of Medicine NY, (Clinical research in Neurocardiac Electrophysiology)

Predoctoral Fellowship, University of Pennsylvania PA, (Translational research in Cardiac Electrophysiology)

UC Health Location

PROVIDER CARDIOLOGY (UC HEALTH SERVICE AREA)

PROVIDER ICU (UC HEALTH SERVICE AREA)

UCH CARDIOLOGY MID (Midtown Physician Office)

UCP CARDIOLOGY WYO (Wyoming- W. Galbraith)

UH 6S (UC Medical Center)

UH ADMITTING (UC Medical Center)

UH CARDIAC STRESS LAB (Holmes Hospital)

UH CVICU (UC Medical Center)

UH CVR (UC Medical Center)

UH ECG (Holmes Hospital)

UH ELECTROPHYSIOLOGY (Holmes Hospital)

UH ENT (UC Medical Center)

UC Health Clinical Focus

Cardiac Electrophysiology

Cardiology

UC Health Specialities

Cardiovascular Disease

Clinical Cardiac Electrophysiology

Internal Medicine

Certifications

American Board of Internal Medicine

08/22/2011

Research Support

Grant: #R00HL130662 Investigators:DeMazumder, Deeptankar 02-01-2017 -01-31-2020 National Heart, Lung and Blood Institute Autonomic remodeling and modulation therapy in heart failure and sudden death Role:PI $249,000.00 Active Level:Federal

Grant: #AHA 17UNPG33860002 Investigators:DeMazumder, Deeptankar 04-02-2018 -04-01-2019 American Heart Association - National Chapter Critical Health Assessment & Outcomes Study/Score during sleep (CHAOS-sleep) Role:PI $150,000.00 Awarded Level:Private Non-Profit

Grant: #18IFUNP33990024 Investigators:DeMazumder, Deeptankar; Lin, Tracie 04-02-2018 -04-01-2020 American Heart Association - National Chapter Critical Health Assessment & Outcomes Study for predicting acute sleep-disordered breathing (CHAOS SBD) Role:PI $150,000.00 Awarded Level:Private Non-Profit

Grant: #AHA 18AMTG34280046 Investigators:DeMazumder, Deeptankar; Sanagala, Neha Reddy 07-01-2018 -06-30-2020 American Heart Association - National Chapter Critical Health Assessment and Outcomes Study/Score in the cardiovascular ICU (CHAOS-ICU) Role:Collaborator $50,000.00 Active Level:Private Non-Profit

Grant: #NCAI-18-10-APP-UC-DeMazumder / UH54HL119810 Investigators:DeMazumder, Deeptankar 08-01-2018 -07-31-2019 National Heart, Lung and Blood Institute Critical Health Assessment & Outcomes Study/Score (CHAOS) for improved personalized prediction of impending adverse events before clinical presentation Role:PI $122,061.00 Active Level:Federal

Grant: #19AIML34930039 Investigators:DeMazumder, Deeptankar 07-01-2019 -06-30-2021 American Heart Association - National Chapter Critical Health Assessment & Outcomes Study/Score in the cardiovascular ICU (CHAOS-ICU) Role:PI $100,000.00 Awarded Level:Private Non-Profit

Grant: #VUMC 77450_W81XWH1910640 Investigators:DeMazumder, Deeptankar 09-01-2019 -08-31-2020 Department of the Army Medical Research Acquisition Activity Genetic Autonomic Modulation In Vivo to Protect Against Oxidative Stress and Sudden Cardiac Death (SCD) Role:PI $91,153.00 Awarded Level:Federal

Grant: #F31HL1511 Investigators:Crocker, Jeffrey; DeMazumder, Deeptankar 02-01-2020 -01-31-2023 National Heart, Lung and Blood Institute Autonomic remodeling and modulation as mechanism and therapy for sudden cardiac death in heart failure Role:Collaborator $37,697.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Keramati, Ali R; DeMazumder, Deeptankar; Misra, Satish; Chrispin, Jonathan; Assis, Fabrizio R; Raghuram, Chava; Dey, Swati; Calkins, Hugh; Tandri, Harikrishna (2017. )Anterior pericardial access to facilitate electrophysiology study and catheter ablation of ventricular arrhythmias: A single tertiary center experience.Journal of cardiovascular electrophysiology, ,28 (10 ),1189-1195

DeMazumder, Deeptankar (2018. )The Path of an Early Career Physician and Scientist in Cardiac Electrophysiology.Circulation research, ,123 (12 ),1269-1271

Dey, Swati; DeMazumder, Deeptankar; Sidor, Agnieszka; Foster, D Brian; O'Rourke, Brian (2018. )Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure.Circulation research, ,123 (3 ),356-371

Post Graduate Training and Education

2006-2007 Internship - Internal Medicine, Mount Sinai School of Medicine, ,NY

2007-2009 Residency - Internal Medicine, University of Virginia, ,VA

2009-2013 Clinical & Research Fellowships - Cardiology, Johns Hopkins University, ,MD

2013-2016 Clinical & Research Fellowships - Cardiac Electrophysiology, Johns Hopkins University, ,MD

Contact Information

Academic - Office
231 Albert Sabin Way, CVC 3923
Cincinnati  Ohio, 45267-0542
Phone: 513-558-2307
Fax: 513-558-6899
Deeptankar.DeMazumder@uc.edu