Robert F Highsmith , PhD

Doctoral Degree: University of Cincinnati 1972 (Physiology and Biophysics)

Postdoctoral Fellowship: Harvard Medical Schoo Boston, MA, 1974

Intercellular Signalling within the Blood Vessel Wall of Coronary Arteries.

Grant: #53000236-HHMI-04-A0-S0-E0 Investigators:Highsmith, Robert 01-01-2000 -12-31-2005 Howard Hughes Medical Institute Infrastructure for Expression Technology Role:PI $1,933,333.00 Closed Level:Private Non-Profit

Grant: #108782 \ 1 F30HL104892-01; 5F30HL104892-02 Investigators:Highsmith, Robert; Lu, Thomas 07-01-2011 -03-15-2012 National Heart, Lung and Blood Institute miR-21 in the Pathogenesis of Asthma Role:Collaborator $29,892.00 Active Level:Federal

Grant: #F30HL104892 Investigators:Highsmith, Robert; Lu, Thomas 08-16-2012 -08-15-2013 National Heart, Lung and Blood Institute MiR-21 in the Pathogenesis of Asthma Role:Collaborator $45,364.00 Active Level:Federal

Peer Reviewed Publications

Guard, J Roger; Brueggemann, Ralph F; Highsmith, Robert F; Marine, Stephen A; Riep, Josette R; Schick, Leslie C (2005. ) Building research administration applications for the academic health center: a case study. Academic medicine : journal of the Association of American Medical Colleges, , 80 (11 ) ,1032-8

Hubel, C A; Highsmith, R F (1995. ) Endothelin-induced changes in intracellular pH and Ca2+ in coronary smooth muscle: role of Na(+)-H+ exchange. The Biochemical journal, , 310 ( Pt 3) ,1013-20

Pollock, D M; Keith, T L; Highsmith, R F (1995. ) Endothelin receptors and calcium signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 9 (12 ) ,1196-204

Heffernan, M; Chance, A; Hess, E V; Highsmith, R F; FitzGerald, O (1994. ) Alterations in human endothelial cell morphology, proliferation and function by a macrophage-derived factor. Irish journal of medical science, , 163 (8 ) ,359-65

Sawaya, R; Highsmith, R F (1992. ) Postoperative venous thromboembolism and brain tumors: Part III. Biochemical profile. Journal of neuro-oncology, , 14 (2 ) ,113-8

Highsmith, R F; Blackburn, K; Schmidt, D J (1992. ) Endothelin and calcium dynamics in vascular smooth muscle.Annual review of physiology, , 54 ,257-77 More Information

Blackburn, K; Highsmith, R F (1990. ) Nickel inhibits endothelin-induced contractions of vascular smooth muscle. The American journal of physiology, , 258 (6 Pt 1 ) ,C1025-30

Rapoport, R M; Stauderman, K A; Highsmith, R F (1990. ) Effects of EDCF and endothelin on phosphatidylinositol hydrolysis and contraction in rat aorta. The American journal of physiology, , 258 (1 Pt 1 ) ,C122-31

Highsmith, R F; Pang, D C; Rapoport, R M (1989. ) Endothelial cell-derived vasoconstrictors: mechanisms of action in vascular smooth muscle. Journal of cardiovascular pharmacology, , 13 Suppl 5 ,S36-44; discussion S

Whitmer, K R; Williams-Lawson, J S; Highsmith, R F; Schwartz, A (1988. ) Effect of calcium channel modulators on isolated endothelial cells. Biochemical and biophysical research communications, , 154 (2 ) ,591-605

Neely, A N; Nathan, P; Highsmith, R F (1988. ) Plasma proteolytic activity following burns. The Journal of trauma, , 28 (3 ) ,362-7

FitzGerald, O M; Hess, E V; Chance, A; Highsmith, R F (1987. ) Quantitative studies of human monokine-induced endothelial cell elongation. Journal of leukocyte biology, , 41 (5 ) ,421-8

Ramey, J W; Krummen, L A; Wilfinger, W W; Highsmith, R F; Baldwin, D M (1987. ) Effects of a low calcium environment on luteinizing hormone biosynthesis in cultured rat anterior pituitary cells.Endocrinology, , 120 (4 ) ,1514-20 More Information

Ramey, J W; Highsmith, R F; Wilfinger, W W; Baldwin, D M (1987. ) The effects of gonadotropin-releasing hormone and estradiol on luteinizing hormone biosynthesis in cultured rat anterior pituitary cells.Endocrinology, , 120 (4 ) ,1503-13 More Information

Baldwin, D M; Highsmith, R F; Ramey, J W; Krummen, L A (1986. ) An in vitro study of LH release, synthesis and heterogeneity in pituitaries from proestrous and short-term ovariectomized rats. Biology of reproduction, , 34 (2 ) ,304-15

Hickey, K A; Rubanyi, G; Paul, R J; Highsmith, R F (1985. ) Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. The American journal of physiology, , 248 (5 Pt 1 ) ,C550-6

Marcum, J A; Highsmith, R F; Kline, D L (1982. ) Streptokinase-dependent delayed activation of horse plasminogen. Biochimica et biophysica acta, , 709 (1 ) ,19-27

Highsmith, R F (1981. ) Isolation and properties of a plasminogen activator derived from canine vascular tissue. The Journal of biological chemistry, , 256 (13 ) ,6788-95

Highsmith, R F; Burnett, C J; Weirich, C J (1979. ) The interaction of C1-esterase inhibitor and plasmin in human euglobulin. The Journal of laboratory and clinical medicine, , 93 (3 ) ,459-71

Highsmith, R F; Weirich, C J; Burnett, C J (1977. ) Protease inhibitors and human plasmin: interaction in a whole plasma system. Biochemical and biophysical research communications, , 79 (3 ) ,648-56

Highsmith, R F; Rosenberg, R D (1977. ) A rapid and sensitive proteolytic assay for human plasminogen and plasmin using radioiodinated alpha-casein. Thrombosis research, , 11 (2 ) ,131-40

Highsmith, R F; Rosenberg, R D (1974. ) The inhibition of human plasmin by human antithrombin-heparin cofactor. The Journal of biological chemistry, , 249 (14 ) ,4335-8

Highsmith, R F; Kline, D L (1973. ) Plasminogen restoration by the kidney mediated by a plasma factor. The American journal of physiology, , 225 (5 ) ,1032-7

Kline, D L; Highsmith, R F (1973. ) The regulation of blood levels of fibrinolytic enzymes. Series haematologica, , 6 (4 ) ,513-27

Highsmith, R F; Kline, D L (1971. ) Kidney: primary source of plasminogen after acute depletion in the cat. Science (New York, N.Y.), , 174 (4005 ) ,141-2

Physiologist,Cell Biologist,Protein Chemist,Pharmacologist,Protein chemistry,Cellular Physiology,Cellular regulation and integration,Control of biosynthesis,Receptors,Cells and platelets,Acute myocardial infarction,Coronary artery disease,Hemodynamics and vasomotor control,Regional vascular pattern,Thrombosis and embolism,Dose-response studies,Graduate education,Medical education

Academic - Medical Sciences Building
Room 2005G
Cincinnati  Ohio, 45267-0548
Phone: 513-558-5459
Fax: 513-558-2850
robert.highsmith@uc.edu