Gang Huang

Gang Huang

Associate Professor - Aff

Medical Sciences Building

COM Pathology & Lab Medicine - 0529

Cincinnati Childrens Hospital Medical Center
3333 Burnett Ave.
Cincinnati, Ohio 45227

Education

Doctorate, Kyoto University Kyoto, Japan , 2001

Postdoctoral Fellow, Beth Israel Deaconess Medical Center Harvard University, Boston, MA , 2005

Postdoctoral Fellow, Memorial Sloan- Kettering Cancer Center New York, NY , 2009

Publications

Peer Reviewed Publications

Kim, Jung-Hyun; Baddoo, Melody C; Park, Eun Young; Stone, Joshua K; Park, Hyeonsoo; Butler, Thomas W; Huang, Gang; Yan, Xiaomei; Pauli-Behn, Florencia; Myers, Richard M; Tan, Ming; Flemington, Erik K; Lim, Ssang-Taek; Ahn, Eun-Young Erin (2016. ) SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.Molecular cell, , 61 (6 ) ,859-73

Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy (2016. ) Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation.Cell reports, , 14 (8 ) ,1979-90

Park, Jino; Schlederer, Michaela; Schreiber, Martin; Ice, Ryan; Merkel, Olaf; Bilban, Martin; Hofbauer, Sebastian; Kim, Soojin; Addison, Joseph; Zou, Jie; Ji, Chunyan; Bunting, Silvia T; Wang, Zhengqi; Shoham, Menachem; Huang, Gang; Bago-Horvath, Zsuzsanna; Gibson, Laura F; Rojanasakul, Yon; Remick, Scot; Ivanov, Alexey; Pugacheva, Elena; Bunting, Kevin D; Moriggl, Richard; Kenner, Lukas; Tse, William (2015. ) AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.Oncotarget, , 6 (24 ) ,20697-710

Wang, Lan; Man, Na; Sun, Xiao-Jian; Tan, Yurong; Cao, Marta Garcia; Liu, Fan; Hatlen, Megan; Xu, Haiming; Huang, Gang; Mattlin, Meredith; Mehta, Arpit; Rampersaud, Evadnie; Benezra, Robert; Nimer, Stephen D (2015. ) Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression.Blood, , 126 (5 ) ,640-50

Kühn, Michael W M; Hadler, Michael J; Daigle, Scott R; Koche, Richard P; Krivtsov, Andrei V; Olhava, Edward J; Caligiuri, Michael A; Huang, Gang; Bradner, James E; Pollock, Roy M; Armstrong, Scott A (2015. ) MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition.Haematologica, , 100 (5 ) ,e190-3

Roychoudhury, Jayeeta; Clark, Jason P; Gracia-Maldonado, Gabriel; Unnisa, Zeenath; Wunderlich, Mark; Link, Kevin A; Dasgupta, Nupur; Aronow, Bruce; Huang, Gang; Mulloy, James C; Kumar, Ashish R (2015. ) MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia.Blood, , 125 (16 ) ,2544-52

Cui, Yajuan; Tong, Hongyan; Du, Xin; Li, Bing; Gale, Robert Peter; Qin, Tiejun; Liu, Jinqin; Xu, Zefeng; Zhang, Yue; Huang, Gang; Jin, Jie; Fang, Liwei; Zhang, Hongli; Pan, Lijuan; Hu, Naibo; Qu, Shiqiang; Xiao, Zhijian (2015. ) Impact of TET2, SRSF2, ASXL1 and SETBP1 mutations on survival of patients with chronic myelomonocytic leukemia.Experimental hematology & oncology, , 4 ,14

Li, Bing; Xu, Junqing; Li, Chengwen; Gale, Robert Peter; Xu, Zefeng; Qin, Tiejun; Zhang, Yue; Huang, Gang; Fang, Liwei; Zhang, Hongli; Pan, Lijuan; Hu, Naibo; Qu, Shiqiang; Xiao, Zhijian (2014. ) Cytogenetic studies and their prognostic contribution in 565 Chinese patients with primary myelofibrosis.American journal of hematology, , 89 (11 ) ,1043-6

Staber, Philipp B; Zhang, Pu; Ye, Min; Welner, Robert S; Levantini, Elena; Di Ruscio, Annalisa; Ebralidze, Alexander K; Bach, Christian; Zhang, Hong; Zhang, Junyan; Vanura, Katrina; Delwel, Ruud; Yang, Henry; Huang, Gang; Tenen, Daniel G (2014. ) The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Blood, , 124 (15 ) ,2391-9

Sashida, Goro; Harada, Hironori; Matsui, Hirotaka; Oshima, Motohiko; Yui, Makiko; Harada, Yuka; Tanaka, Satomi; Mochizuki-Kashio, Makiko; Wang, Changshan; Saraya, Atsunori; Muto, Tomoya; Hayashi, Yoshihiro; Suzuki, Kotaro; Nakajima, Hiroshi; Inaba, Toshiya; Koseki, Haruhiko; Huang, Gang; Kitamura, Toshio; Iwama, Atsushi (2014. ) Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.Nature communications, , 5 ,4177

Cui, Rui; Gale, Robert Peter; Zhu, Guoqing; Xu, Zefeng; Qin, Tiejun; Zhang, Yue; Huang, Gang; Li, Bing; Fang, Liwei; Zhang, Hongli; Pan, Lijuan; Hu, Naibo; Qu, Shiqiang; Xiao, Zhijian (2014. ) Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions.Leukemia research, , 38 (5 ) ,545-50

Zhao, Xinghui; Chen, Aili; Yan, Xiaomei; Zhang, Yue; He, Fuhong; Hayashi, Yoshihiro; Dong, Yunzhu; Rao, Yalan; Li, Bo; Conway, Rajeana M; Maiques-Diaz, Alba; Elf, Shannon E; Huang, Nuomin; Zuber, Johannes; Xiao, Zhijian; Tse, William; Tenen, Daniel G; Wang, Qianfei; Chen, Wei; Mulloy, James C; Nimer, Stephen D; Huang, Gang (2014. ) Downregulation of RUNX1/CBF? by MLL fusion proteins enhances hematopoietic stem cell self-renewal.Blood, , 123 (11 ) ,1729-38

Zhu, Xiaofan; He, Fuhong; Zeng, Huimin; Ling, Shaoping; Chen, Aili; Wang, Yaqin; Yan, Xiaomei; Wei, Wei; Pang, Yakun; Cheng, Hui; Hua, Chunlan; Zhang, Yue; Yang, Xuejing; Lu, Xin; Cao, Lihua; Hao, Lingtong; Dong, Lili; Zou, Wei; Wu, Jun; Li, Xia; Zheng, Si; Yan, Jin; Zhou, Jing; Zhang, Lixia; Mi, Shuangli; Wang, Xiaojuan; Zhang, Li; Zou, Yao; Chen, Yumei; Geng, Zhe; Wang, Jianmin; Zhou, Jianfeng; Liu, Xin; Wang, Jianxiang; Yuan, Weiping; Huang, Gang; Cheng, Tao; Wang, Qian-Fei (2014. ) Identification of functional cooperative mutations of SETD2 in human acute leukemia.Nature genetics, , 46 (3 ) ,287-93

Li, Ailing; Yang, Youyang; Gao, Chong; Lu, Jiayun; Jeong, Ha-Won; Liu, Bee H; Tang, Ping; Yao, Xiaopan; Neuberg, Donna; Huang, Gang; Tenen, Daniel G; Chai, Li (2013. ) A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis.The Journal of clinical investigation, , 123 (10 ) ,4195-207

Goyama, Susumu; Schibler, Janet; Cunningham, Lea; Zhang, Yue; Rao, Yalan; Nishimoto, Nahoko; Nakagawa, Masahiro; Olsson, Andre; Wunderlich, Mark; Link, Kevin A; Mizukawa, Benjamin; Grimes, H Leighton; Kurokawa, Mineo; Liu, P Paul; Huang, Gang; Mulloy, James C (2013. ) Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.The Journal of clinical investigation, , 123 (9 ) ,3876-88

Schönheit, Jörg; Kuhl, Christiane; Gebhardt, Marie Luise; Klett, Francisco Fernández; Riemke, Pia; Scheller, Marina; Huang, Gang; Naumann, Ronald; Leutz, Achim; Stocking, Carol; Priller, Josef; Andrade-Navarro, Miguel A; Rosenbauer, Frank (2013. ) PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.Cell reports, , 3 (5 ) ,1617-28

Zhao, Xinghui; Zhao, Zhanzhong; Guo, Junwei; Huang, Peitang; Zhu, Xudong; Zhou, Xiaowei; Yang, Zhixin; Zhao, Lixia; Xu, Long; Xu, Junjie; Fu, Ling; Zhang, Jun; Zhang, Xiaopeng; Dong, Yunzhu; Huang, Gang; Wang, Qianfei; Li, Bo; Song, Xiaohong; Yang, Xiuxu; Liu, Shuling; Yi, Shaoqiong; Yu, Ting; Yu, Changming; Hou, Lihua; Li, Jianmin; Chen, Wei (2013. ) Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line.Journal of biomolecular screening, , 18 (4 ) ,378-87

Staber, Philipp B; Zhang, Pu; Ye, Min; Welner, Robert S; Nombela-Arrieta, César; Bach, Christian; Kerenyi, Marc; Bartholdy, Boris A; Zhang, Hong; Alberich-Jordà, Meritxell; Lee, Sanghoon; Yang, Henry; Ng, Felicia; Zhang, Junyan; Leddin, Mathias; Silberstein, Leslie E; Hoefler, Gerald; Orkin, Stuart H; Göttgens, Berthold; Rosenbauer, Frank; Huang, Gang; Tenen, Daniel G (2013. ) Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells.Molecular cell, , 49 (5 ) ,934-46

Hirai, Hideyo; Kamio, Naoka; Huang, Gang; Matsusue, Akiko; Ogino, Shinpei; Kimura, Nobuhiko; Satake, Sakiko; Ashihara, Eishi; Imanishi, Jiro; Tenen, Daniel G; Maekawa, Taira (2013. ) Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein ?.PloS one, , 8 (1 ) ,e54862

Zhang, Yue; Yan, Xiaomei; Sashida, Goro; Zhao, Xinghui; Rao, Yalan; Goyama, Susumu; Whitman, Susan P; Zorko, Nicholas; Bernot, Kelsie; Conway, Rajeana M; Witte, David; Wang, Qian-Fei; Tenen, Daniel G; Xiao, Zhijian; Marcucci, Guido; Mulloy, James C; Grimes, H Leighton; Caligiuri, Michael A; Huang, Gang (2012. ) Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.Blood, , 120 (5 ) ,1118-29

Zorko, Nicholas A; Bernot, Kelsie M; Whitman, Susan P; Siebenaler, Ronald F; Ahmed, Elshafa H; Marcucci, Gabriele G; Yanes, Daniel A; McConnell, Kathleen K; Mao, Charlene; Kalu, Chidimma; Zhang, Xiaoli; Jarjoura, David; Dorrance, Adrienne M; Heerema, Nyla A; Lee, Benjamin H; Huang, Gang; Marcucci, Guido; Caligiuri, Michael A (2012. ) Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias.Blood, , 120 (5 ) ,1130-6

Huang, Gang; Zhao, Xinghui; Wang, Lan; Elf, Shannon; Xu, Hao; Zhao, Xinyang; Sashida, Goro; Zhang, Yue; Liu, Yan; Lee, Jennifer; Menendez, Silvia; Yang, Youyang; Yan, Xiaomei; Zhang, Pu; Tenen, Daniel G; Osato, Motomi; Hsieh, James J-D; Nimer, Stephen D (2011. ) The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.Blood, , 118 (25 ) ,6544-52

Wang, Lan; Gural, Alexander; Sun, Xiao-Jian; Zhao, Xinyang; Perna, Fabiana; Huang, Gang; Hatlen, Megan A; Vu, Ly; Liu, Fan; Xu, Haiming; Asai, Takashi; Xu, Hao; Deblasio, Tony; Menendez, Silvia; Voza, Francesca; Jiang, Yanwen; Cole, Philip A; Zhang, Jinsong; Melnick, Ari; Roeder, Robert G; Nimer, Stephen D (2011. ) The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.Science (New York, N.Y.), , 333 (6043 ) ,765-9

Sashida, Goro; Bae, Narae; Di Giandomenico, Silvana; Asai, Takashi; Gurvich, Nadia; Bazzoli, Elena; Liu, Yan; Huang, Gang; Zhao, Xinyang; Menendez, Silvia; Nimer, Stephen D (2011. ) The mef/elf4 transcription factor fine tunes the DNA damage response.Cancer research, , 71 (14 ) ,4857-65

Xiong, Yin; Li, Zejuan; Ji, Min; Tan, Aik-Choon; Bemis, Judson; Tse, Jove-Victor; Huang, Gang; Park, Jino; Ji, Chunyan; Chen, Jianjun; Bemis, Lynne T; Bunting, Kevin D; Tse, William (2011. ) MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML.British journal of haematology, , 153 (6 ) ,753-7

O'Brien, Karen B; Alberich-Jordà, Meritxell; Yadav, Neelu; Kocher, Olivier; Diruscio, Annalisa; Ebralidze, Alexander; Levantini, Elena; Sng, Natasha J L; Bhasin, Manoj; Caron, Tyler; Kim, Daehoon; Steidl, Ulrich; Huang, Gang; Halmos, Balázs; Rodig, Scott J; Bedford, Mark T; Tenen, Daniel G; Kobayashi, Susumu (2010. ) CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.Development (Cambridge, England), , 137 (13 ) ,2147-56

Kamikubo, Yasuhiko; Zhao, Ling; Wunderlich, Mark; Corpora, Takeshi; Hyde, R Katherine; Paul, Thomas A; Kundu, Mondira; Garrett, Lisa; Compton, Sheila; Huang, Gang; Wolff, Linda; Ito, Yoshiaki; Bushweller, John; Mulloy, James C; Liu, P Paul (2010. ) Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1.Cancer cell, , 17 (5 ) ,455-68

Liu, Yan; Elf, Shannon E; Miyata, Yasuhiko; Sashida, Goro; Liu, Yuhui; Huang, Gang; Di Giandomenico, Silvana; Lee, Jennifer M; Deblasio, Anthony; Menendez, Silvia; Antipin, Jack; Reva, Boris; Koff, Andrew; Nimer, Stephen D (2009. ) p53 regulates hematopoietic stem cell quiescence.Cell stem cell, , 4 (1 ) ,37-48

Contact Information

Academic - Cincinnati Childrens Hospital Medical Center
3333 Burnett Ave.
Cincinnati  Ohio, 45227
Phone: (513) 636-3214
Fax: (513) 636-3768
Gang.Huang@cchmc.org