Helen Jones

Helen N. Jones

Assistant Professor of Surgery

Childrens Hospital Bldg R

COM Surgery Pediatric - 0054

Cincinnati Children's Hospital Medical Center
Department of Pediatric Surgery
Cincinnati, Ohio 45229

Education

Bachelor's Degree, University of St. Andrews - Scotland 2000 (Biochemistry)

Doctoral Degree, University of Aberdeen - Scotland 2005 (Physiology)

Publications

Peer Reviewed Publications

Chaturvedi, Vandana; Ertelt, James M; Jiang, Tony T; Kinder, Jeremy M; Xin, Lijun; Owens, Kathryn J; Jones, Helen N; Way, Sing Sing (2015. )CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage.The Journal of clinical investigation, ,125 (4 ),1713-25

Troja, Weston; Kil, Kicheol; Klanke, Charles; Jones, Helen N (2014. )Interaction between human placental microvascular endothelial cells and a model of human trophoblasts: effects on growth cycle and angiogenic profile.Physiological reports, ,2 (3 ),e00244

Lager, Susanne; Gaccioli, Francesca; Ramirez, Vanessa I; Jones, Helen N; Jansson, Thomas; Powell, Theresa L (2013. )Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4.Journal of lipid research, ,54 (3 ),725-33

Jansson, Nina; Rosario, Fredrick J; Gaccioli, Francesca; Lager, Susanne; Jones, Helen N; Roos, Sara; Jansson, Thomas; Powell, Theresa L (2013. )Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies.The Journal of clinical endocrinology and metabolism, ,98 (1 ),105-13

Jones, Helen N; Crombleholme, Timothy; Habli, Mounira (2013. )Adenoviral-mediated placental gene transfer of IGF-1 corrects placental insufficiency via enhanced placental glucose transport mechanisms.PloS one, ,8 (9 ),e74632

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,20 (4 ),592-600

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Katz, Anna B; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M (2012. )Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis.PloS one, ,7 (8 ),e43633

Wang, Kang; Dong, Hai-Qing; Wen, Hui-Yun; Xu, Meng; Li, Cao; Li, Yong-Yong; Jones, Helen N; Shi, Dong-Lu; Zhang, Xian-Zheng (2011. )Novel vesicles self-assembled from amphiphilic star-armed PEG/polypeptide hybrid copolymers for drug delivery.Macromolecular bioscience, ,11 (1 ),65-71

Jones, Helen N; Jansson, Thomas; Powell, Theresa L (2010. )Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells.Diabetes, ,59 (5 ),1161-70

Jones, H N; Jansson, T; Powell, T L (2009. )IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2.American journal of physiology. Cell physiology, ,297 (5 ),C1228-35

Jones, Helen N; Woollett, Laura A; Barbour, Nicolette; Prasad, Puttur D; Powell, Theresa L; Jansson, Thomas (2009. )High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,23 (1 ),271-8

Jones, H N; Powell, T L; Jansson, T Regulation of placental nutrient transport--a review.Placenta, ,28 (8-9 ),763-74

Jones, Helen N; Ashworth, Cheryl J; Page, Ken R; McArdle, Harry J (2006. )Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo).American journal of physiology. Endocrinology and metabolism, ,291 (3 ),E596-603

Jones, H N; Ashworth, C J; Page, K R; McArdle, H J (2006. )Expression and adaptive regulation of amino acid transport system A in a placental cell line under amino acid restriction.Reproduction (Cambridge, England), ,131 (5 ),951-60

Jones, Helen N; Olbrych, Stephanie K; Smith, Kathleen L; Cnota, James F; Habli, Mounira; Ramos-Gonzales, Osniel; Owens, Kathryn J; Hinton, Andrea C; Polzin, William J; Muglia, Louis J; Hinton, Robert B (2015. )Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation.Placenta, ,36 (10 ),1078-86

Abd Ellah NH, Taylor L, Ayres N, Elmahdy MM, Fetih GN, Jones HN, Ibrahim EA, Pauletti GM (2016. )NF-κB decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells .Cancer Gene Therapy, ,23 (5 ),149-55

Research and Practice Interests

Regulation of Placental Growth and Function

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
Department of Pediatric Surgery
Cincinnati  Ohio, 45229
Phone: 513-636-6259
helen.jones@cchmc.org