Helen Jones

Helen N. Jones

Assistant Professor of Surgery

Childrens Hospital Bldg R

COM Surgery Pediatric - 0054

Cincinnati Children's Hospital Medical Center
Department of Pediatric Surgery
Cincinnati, Ohio 45229

Education

Bachelor's Degree, University of St. Andrews - Scotland 2000 (Biochemistry)

Doctoral Degree, University of Aberdeen - Scotland 2005 (Physiology)

Research and Practice Interests

Regulation of Placental Growth and Function

Publications

Peer Reviewed Publications

Chaturvedi, Vandana; Ertelt, James M; Jiang, Tony T; Kinder, Jeremy M; Xin, Lijun; Owens, Kathryn J; Jones, Helen N; Way, Sing Sing (2015. )CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage.The Journal of clinical investigation, ,125 (4 ),1713-25

Troja, Weston; Kil, Kicheol; Klanke, Charles; Jones, Helen N (2014. )Interaction between human placental microvascular endothelial cells and a model of human trophoblasts: effects on growth cycle and angiogenic profile.Physiological reports, ,2 (3 ),e00244

Lager, Susanne; Gaccioli, Francesca; Ramirez, Vanessa I; Jones, Helen N; Jansson, Thomas; Powell, Theresa L (2013. )Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4.Journal of lipid research, ,54 (3 ),725-33

Jansson, Nina; Rosario, Fredrick J; Gaccioli, Francesca; Lager, Susanne; Jones, Helen N; Roos, Sara; Jansson, Thomas; Powell, Theresa L (2013. )Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies.The Journal of clinical endocrinology and metabolism, ,98 (1 ),105-13

Jones, Helen N; Crombleholme, Timothy; Habli, Mounira (2013. )Adenoviral-mediated placental gene transfer of IGF-1 corrects placental insufficiency via enhanced placental glucose transport mechanisms.PloS one, ,8 (9 ),e74632

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M Pseudotyped adeno-associated viral vector tropism and transduction efficiencies in murine wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, ,20 (4 ),592-600

Keswani, Sundeep G; Balaji, Swathi; Le, Louis; Leung, Alice; Katz, Anna B; Lim, Foong-Yen; Habli, Mounira; Jones, Helen N; Wilson, James M; Crombleholme, Timothy M (2012. )Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis.PloS one, ,7 (8 ),e43633

Wang, Kang; Dong, Hai-Qing; Wen, Hui-Yun; Xu, Meng; Li, Cao; Li, Yong-Yong; Jones, Helen N; Shi, Dong-Lu; Zhang, Xian-Zheng (2011. )Novel vesicles self-assembled from amphiphilic star-armed PEG/polypeptide hybrid copolymers for drug delivery.Macromolecular bioscience, ,11 (1 ),65-71

Jones, Helen N; Jansson, Thomas; Powell, Theresa L (2010. )Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells.Diabetes, ,59 (5 ),1161-70

Jones, H N; Jansson, T; Powell, T L (2009. )IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2.American journal of physiology. Cell physiology, ,297 (5 ),C1228-35

Jones, Helen N; Woollett, Laura A; Barbour, Nicolette; Prasad, Puttur D; Powell, Theresa L; Jansson, Thomas (2009. )High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ,23 (1 ),271-8

Jones, H N; Powell, T L; Jansson, T Regulation of placental nutrient transport--a review.Placenta, ,28 (8-9 ),763-74

Jones, Helen N; Ashworth, Cheryl J; Page, Ken R; McArdle, Harry J (2006. )Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo).American journal of physiology. Endocrinology and metabolism, ,291 (3 ),E596-603

Jones, H N; Ashworth, C J; Page, K R; McArdle, H J (2006. )Expression and adaptive regulation of amino acid transport system A in a placental cell line under amino acid restriction.Reproduction (Cambridge, England), ,131 (5 ),951-60

Jones, Helen N; Olbrych, Stephanie K; Smith, Kathleen L; Cnota, James F; Habli, Mounira; Ramos-Gonzales, Osniel; Owens, Kathryn J; Hinton, Andrea C; Polzin, William J; Muglia, Louis J; Hinton, Robert B (2015. )Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation.Placenta, ,36 (10 ),1078-86

Abd Ellah NH, Taylor L, Ayres N, Elmahdy MM, Fetih GN, Jones HN, Ibrahim EA, Pauletti GM (2016. )NF-κB decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells .Cancer Gene Therapy, ,23 (5 ),149-55

Carrillo M.; Chuecos M.; Fry M.V.; Jones H.N.; Owens K.; Schlabritz-Loutsevitch N.; Stephens K.K.; Sumser E.K.; Wilson R.L. (04-01-2020. )Nanoparticle mediated increased insulin-like growth factor 1 expression enhances human placenta sync.Placenta, ,93 ,1-7

Jones H.N.; Muglia L.J.; Pavlicev M.; Zhang X. (02-01-2020. )Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.Molecular Biology and Evolution, ,37 (2 ),507-523

Godarova A.; Herr A.; Hoebe K.; Janssen E.; Jones H.; Lampe K.; Locker K.; Plas D.; Sliz A. (08-02-2019. )Gab3 is required for IL-2- And IL-15-induced NK cell expansion and limits trophoblast invasion durin.Science Immunology, ,4 (38 ),

Ackerman W.E.; Brockway H.M.; Buhimschi C.S.; Buhimschi I.A.; Jones H.N.; Kallapur S.G.; Muglia L.J. (01-01-2019. )Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm .PLoS ONE, ,14 (11 ),

Dunn-Fletcher C.; Hu Y.; Huffman E.; Jones H.; Lamm K.; Macfarlan T.; Muglia L.; Mukherjee A.; Pavlicev M.; Sun M.; Swaggart K.; Thiele K.; Tumukuntala S.; Wolf G.; Zhang X.; Zoubovsky S. (09-01-2018. )Anthropoid primate–specific retroviral element THE1B controls expression of CRH in placenta and alte.PLoS Biology, ,16 (9 ),

Cnota J.; Courtney J.; Jones H. (08-07-2018. )The role of abnormal placentation in congenital heart disease; Cause, correlate, or consequence?.Frontiers in Physiology, ,9 (AUG ),

Davidson W.; Jones H.; Melchior J.; Moore S.; Prentice A.; Rebholz S.; Welge J.; Woollett L. (02-01-2018. )Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth.FASEB Journal, ,32 (2 ),717-727

James J.; Johnson M.; Jones H.; Lamm K.; Muglia L.; Muntifering M.; Phillips J.; Redline R.; Rokas A. (01-08-2018. )Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome.eLife, ,7 ,

Adibi J.; Burton G.; Clifton V.; Collins S.; Frias A.; Gierman L.; Grigsby P.; Jones H.; Lee C.; Maloyan A.; Markert U.; Morales-Prieto D.; Murthi P.; Myatt L.; O'Tierney-Ginn P.; Pollheimer J.; Roberts V.; Robinson W.; Salafia C.; Schabel M.; Shah D.; Sled J.; Vaillancourt C.; Weber M. (12-01-2017. )IFPA meeting 2016 workshop report II: Placental imaging, placenta and development of other organs, s.Placenta, ,60 ,S10-S14

Jansson T.; Jones H. (11-01-2017. )Preface.Placenta, ,59 ,S1

Chavan A.; Dunn-Fletcher C.; Jones H.; Kallapur S.; Maziarz J.; Muglia L.; Owens K.; Pavli?ev M.; Wagner G. (03-01-2017. )Single-cell transcriptomics of the human placenta: Inferring the cell communication network of the m.Genome Research, ,27 (3 ),349-361

Albrecht C.; Caniggia I.; Clifton V.; Göhner C.; Harris L.; Hemmings D.; Jawerbaum A.; Johnstone E.; Jones H.; Keelan J.; Lewis R.; Mitchell M.; Murthi P.; Powell T.; Saffery R.; Salomon C.; Smith R.; Vaillancourt C.; Wadsack C. (12-01-2016. )IFPA meeting 2015 workshop report III: nanomedicine applications and exosome biology, xenobiotics an.Placenta, ,48 ,S12-S16

Ayres N.; Ellah N.; Jones H.; Owens K.; Pauletti G.; Taylor L.; Troja W. (10-16-2015. )Development of non-viral, trophoblast-specific gene delivery for placental therapy.PLoS ONE, ,10 (10 ),

Crombleholme T.; Habli M.; Jones H. (02-01-2014. )Regulation of amino acid transporters by adenoviral-mediated human insulin-like growth factor-1 in a.Placenta, ,35 (2 ),132-138

Jones H.; Kil K.; Klanke C.; Troja W. (01-01-2014. )Interaction between human placental microvascular endothelial cells and a model of human trophoblast.Physiological Reports, ,2 (3 ),

Aronow B.; Crombleholme T.; Habli M.; Jones H.; Omar K. (12-01-2013. )Recapitulation of characteristics of human placental vascular insufficiency in a novel mouse model.Placenta, ,34 (12 ),1150-1158

Andersen H.; Gambling L.; Jones H.; McArdle H. (04-01-2008. )Copper and iron transport across the placenta: Regulation and interactions.Journal of Neuroendocrinology, ,20 (4 ),427-431

Constancia M.; Detmar J.; Ferguson-Smith A.; Hemberger M.; Jammes H.; Jones H.; Kelsey G.; Lewis A.; Moore T.; Roberts C. (09-01-2006. )Erratum to "Epigenetics and Imprinting of the Trophoblast - A Workshop Report" [Placenta 27, supplem.Placenta, ,27 (9-10 ),1036

Andersen H.; Gambling L.; Jones H.; McArdle H. (04-01-2006. )Fetal Programming: Causes and Consequences as Revealed by Studies of Dietary Manipulation in Rats - .Placenta, ,27 (SUPPL. ),56-60

Constancia M.; Detmar J.; Ferguson-Smith A.; Hemberger M.; Jammes H.; Jones H.; Kelsey G.; Lewis A.; Moore T.; Roberts C. (01-01-2006. )Epigenetics and Imprinting of the Trophoblast - A Workshop Report.Placenta, ,27 (SUPPL. ),122-126

Contact Information

Academic - Cincinnati Children's Hospital Medical Center
Department of Pediatric Surgery
Cincinnati  Ohio, 45229
Phone: 513-636-6259
helen.jones@cchmc.org