Scott Langevin

Scott M Langevin

Assoc Professor

Kettering Lab Complex

243

COM EH Epi Langevin Lab - 0056

Kettering Laboratory
160 Panzeca Way, ML0056
Cincinnati, Ohio 45267

Professional Summary

My area of expertise is the molecular epidemiology of cancer, primarily for malignancies originating in the upper aerodigestive tract. My research interests include cancer-associated epigenetic alterations, genetic/epigenetic-environment interactions, identification and evaluation of diagnostic and prognostic biomarkers, and the epidemiology of head and neck cancer.

Education

MHA, Quinnipiac University Hamden, CT, 2005

PhD, University of Pittsburgh Graduate School of Public Health Pittsburgh, PA, 2010 (Epidemiology)

BS, Siena College Loudonville, NY, 1999 (Biology)

Positions and Work Experience

2010 -2013 Postdoctoral Research Fellow, Brown University, Providence, RI

2013 -2019 Assistant Professor of Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH

2019 -To Present Associate Professor of Epidemiology, University of Cincinnati College of Medicine,

Research Support

Grant: #K22CA172358 Investigators:Langevin, Scott 09-25-2013 -08-31-2016 National Cancer Institute Epigenetic alterations in oral rinse as biomarkers of oral and pharyngeal cancer Role:PI $103,107.00 Awarded Level:Federal

Grant: #SRS 009255 Investigators:Casper, Keith; Langevin, Scott 07-01-2014 -07-01-2015 Brandon C. Gromada Head and Neck Cancer Foundation A Comprehensive Study of Common Mutations in Sinonasal Cancer Role:PI $15,000.00 Awarded Level:Private Non-Profit

Grant: #Check 3567 Investigators:Langevin, Scott; Wise-Draper, Trisha; Zhang, Xiang 01-01-2016 -12-31-2016 Elsa U. Pardee Foundation Targeted Mutation Sequencing to Predict Definitive Chemoradiation Response for Head and Neck Cancer Role:PI $168,947.00 Awarded Level:Private Non-Profit

Grant: #Gromada Investigators:Langevin, Scott; Wise-Draper, Trisha 07-01-2016 -06-30-2017 Brandon C. Gromada Head and Neck Cancer Foundation Efficacy of an LSD1 Inhibitor (GSK2879552) for Treating Sinonasal Squamous Cancer Role:PI $20,000.00 Active Level:Private Non-Profit

Grant: #R56 HL128493 Investigators:Chen, Aimin; Deka, Ranjan; Langevin, Scott; Leung, Yuet Kin; Medvedovic, Mario 09-19-2016 -08-31-2017 National Heart, Lung and Blood Institute Integrated GWAS and EWAS of Cardiometabolic Traits in an Island Population Role:Collaborator $677,923.00 Active Level:Federal

Grant: #R21DE027227 Investigators:Kasper, Susan; Langevin, Scott; Medvedovic, Mario; Wise-Draper, Trisha; Zhang, Xiang 09-01-2017 -08-31-2019 National Institute of Dental and Craniofacial Research Exosomal miRNA as Salivary Biomarkers for HPV+ Head and Neck Carcinoma Role:PI $239,250.00 Awarded Level:Federal

Grant: #RSG-18-148-01-CCE Investigators:Langevin, Scott 01-01-2019 -12-31-2022 American Cancer Society - National Chapter Oral Rinse Methylation for Follow-Up Surveillance of Oral/Pharyngeal Cancer Role:PI $782,000.00 Awarded Level:Private Non-Profit

Publications

Peer Reviewed Publications

Tan, Xinmiao; Nelson, Heather H; Langevin, Scott M; McClean, Michael; Marsit, Carmen J; Waterboer, Tim; Pawlita, Michael; Kelsey, Karl T; Michaud, Dominique S (2014. )Obesity and head and neck cancer risk and survival by human papillomavirus serology.Cancer causes & control : CCC, ,

Taioli, E.; Ragin, C.; Wang, X. H.; Chen, J.; Langevin, S. M.; Brown, A. R.; Gollin, S. M.; Garte, S.; Sobol, R. W. (2009. )Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation .BMC Cancer, ,9 (8 ),354

Langevin, Scott M; Christensen, Brock C (2014. )Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis.Cancer medicine, ,3 (5 ),1385-95

Langevin, S. M.; Lin, D.; Matsuo, K.; Gao, C. M.; Takezaki, T.; Stolzenberg-Solomon, R. Z.; Vasavi, M.; Hasan, Q.; Taioli, E. (2009. )Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer .Toxicol Lett, ,184 (2 ),73-80

Michaud, Dominique S; Langevin, Scott M; Eliot, Melissa; Nelson, Heather H; Pawlita, Michael; McClean, Michael D; Kelsey, Karl T (2014. )High-risk HPV types and head and neck cancer.International journal of cancer. Journal international du cancer, ,135 (7 ),1653-61

Langevin, S. M.; Ioannidis, J. P.; Vineis, P.; Taioli, E.; Genetic Susceptibility to Environmental Carcinogens, group (2010. )Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines .Pharmacogenet Genomics, ,20 (10 ),586-97

Langevin, Scott M; Butler, Rondi A; Eliot, Melissa; Pawlita, Michael; Maccani, Jennifer Z J; McClean, Michael D; Kelsey, Karl T (2014. )Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma.Oral oncology, ,

Langevin, S. M.; Stone, R. A.; Bunker, C. H.; Grandis, J. R.; Sobol, R. W.; Taioli, E. (2010. )MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index .Carcinogenesis, ,31 (5 ),864-70

Kwok, J.; Langevin, S. M.; Argiris, A.; Grandis, J. R.; Gooding, W. E.; Taioli, E. (2010. )The impact of health insurance status on the survival of patients with head and neck cancer .Cancer, ,116 (2 ),476-85

Langevin, Scott M; Houseman, E Andres; Accomando, William P; Koestler, Devin C; Christensen, Brock C; Nelson, Heather H; Karagas, Margaret R; Marsit, Carmen J; Wiencke, John K; Kelsey, Karl T (2014. )Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.Epigenetics : official journal of the DNA Methylation Society, ,9 (6 ),884-95

Ragin, C. C.; Langevin, S. M.; Marzouk, M.; Grandis, J.; Taioli, E. (2011. )Determinants of head and neck cancer survival by race .Head Neck, ,33 (8 ),1092-8

Langevin, Scott M; Kratzke, Robert A; Kelsey, Karl T (2014. )Epigenetics of lung cancer.Translational research : the journal of laboratory and clinical medicine, ,

Langevin, S. M.; Grandis, J. R.; Taioli, E. (2011. )Female hormonal and reproductive factors and head and neck squamous cell carcinoma risk .Cancer Lett, ,310 (2 ),216-21

Langevin, Scott M; McClean, Michael D; Michaud, Dominique S; Eliot, Melissa; Nelson, Heather H; Kelsey, Karl T (2013. )Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case-control study conducted in the greater Boston area.Cancer medicine, ,2 (6 ),978-86

Langevin, S. M.; Stone, R. A.; Bunker, C. H.; Lyons-Weiler, M. A.; LaFramboise, W. A.; Kelly, L.; Seethala, R. R.; Grandis, J. R.; Sobol, R. W.; Taioli, E. (2011. )MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck .Cancer, ,117 (7 ),1454-62

Langevin, Scott M; O'Sullivan, Mattie H; Valerio, Jennifer L; Pawlita, Michael; Applebaum, Katie M; Eliot, Melissa; McClean, Michael D; Kelsey, Karl T (2013. )Occupational asbestos exposure is associated with pharyngeal squamous cell carcinoma in men from the greater Boston area.Occupational and environmental medicine, ,70 (12 ),858-63

Langevin, S. M.; Houseman, E. A.; Christensen, B. C.; Wiencke, J. K.; Nelson, H. H.; Karagas, M. R.; Marsit, C. J.; Kelsey, K. T. (2011. )The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood .Epigenetics, ,6 (7 ),908-19

Langevin, Scott M; Kelsey, Karl T (2013. )The fate is not always written in the genes: epigenomics in epidemiologic studies.Environmental and molecular mutagenesis, ,54 (7 ),533-41

Michaud, D. S.; Langevin, S. M.; Eliot, M.; Nelson, H. H.; McClean, M. D.; Christensen, B. C.; Marsit, C. J.; Kelsey, K. T. (2012. )Allergies and risk of head and neck cancer .Cancer Causes Control, ,23 (8 ),1317-22

Koestler, Devin C; Christensen, Brock; Karagas, Margaret R; Marsit, Carmen J; Langevin, Scott M; Kelsey, Karl T; Wiencke, John K; Houseman, E Andres (2013. )Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis.Epigenetics : official journal of the DNA Methylation Society, ,8 (8 ),816-26

Wilhelm-Benartzi, C. S.; Houseman, E. A.; Maccani, M. A.; Poage, G. M.; Koestler, D. C.; Langevin, S. M.; Gagne, L. A.; Banister, C. E.; Padbury, J. F.; Marsit, C. J. (2012. )In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta .Environ Health Perspect, ,120 (2 ),296-302

Eliot, Melissa N; Michaud, Dominique S; Langevin, Scott M; McClean, Michael D; Kelsey, Karl T (2013. )Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma.Cancer causes & control : CCC, ,24 (7 ),1315-22

Langevin, S. M.; Koestler, D. C.; Christensen, B. C.; Butler, R. A.; Wiencke, J. K.; Nelson, H. H.; Houseman, E. A.; Marsit, C. J.; Kelsey, K. T. (2012. )Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study .Epigenetics, ,7 (3 ),291-9

Langevin, Scott M; Michaud, Dominique S; Marsit, Carmen J; Nelson, Heather H; Birnbaum, Ariel E; Eliot, Melissa; Christensen, Brock C; McClean, Michael D; Kelsey, Karl T (2013. )Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, ,22 (6 ),1061-8

Koestler, D. C.; Marsit, C. J.; Christensen, B. C.; Accomando, W.; Langevin, S. M.; Houseman, E. A.; Nelson, H. H.; Karagas, M. R.; Wiencke, J. K.; Kelsey, K. T. (2012. )Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers .Cancer Epidemiol Biomarkers Prev, ,21 (8 ),1293-302

Zhou, Jiachen; Michaud, Dominique S; Langevin, Scott M; McClean, Michael D; Eliot, Melissa; Kelsey, Karl T (2013. )Smokeless tobacco and risk of head and neck cancer: evidence from a case-control study in New England.International journal of cancer. Journal international du cancer, ,132 (8 ),1911-7

Langevin, S. M.; Michaud, D. S.; Eliot, M.; Peters, E. S.; McClean, M. D.; Kelsey, K. T. (2012. )Regular dental visits are associated with earlier stage at diagnosis for oral and pharyngeal cancer .Cancer Causes Control, ,23 (11 ),1821-9

Langevin, Scott M; Michaud, Dominique S; Eliot, Melissa; Peters, Edward S; McClean, Michael D; Kelsey, Karl T (2012. )Regular dental visits are associated with earlier stage at diagnosis for oral and pharyngeal cancer.Cancer causes & control : CCC, ,23 (11 ),1821-9

Koestler, D. C.; Christensen, B.; Karagas, M. R.; Marsit, C. J.; Langevin, S. M.; Kelsey, K. T.; Wiencke, J. K.; Houseman, E. A. (2013. )Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis .Epigenetics, ,8 (8 ),816-26

Michaud, Dominique S; Langevin, Scott M; Eliot, Melissa; Nelson, Heather H; McClean, Michael D; Christensen, Brock C; Marsit, Carmen J; Kelsey, Karl T (2012. )Allergies and risk of head and neck cancer.Cancer causes & control : CCC, ,23 (8 ),1317-22

Langevin, S. M.; Michaud, D. S.; Marsit, C. J.; Nelson, H. H.; Birnbaum, A. E.; Eliot, M.; Christensen, B. C.; McClean, M. D.; Kelsey, K. T. (2013. )Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma .Cancer Epidemiol Biomarkers Prev, ,22 (6 ),1061-8

Koestler, Devin C; Marsit, Carmen J; Christensen, Brock C; Accomando, William; Langevin, Scott M; Houseman, E Andres; Nelson, Heather H; Karagas, Margaret R; Wiencke, John K; Kelsey, Karl T (2012. )Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, ,21 (8 ),1293-302

Langevin, S. M.; O'Sullivan, M. H.; Valerio, J. L.; Pawlita, M.; Applebaum, K. M.; Eliot, M.; McClean, M. D.; Kelsey, K. T. (2013. )Occupational asbestos exposure is associated with pharyngeal squamous cell carcinoma in men from the greater Boston area .Occup Environ Med, ,70 (12 ),858-63

Langevin, Scott M; Koestler, Devin C; Christensen, Brock C; Butler, Rondi A; Wiencke, John K; Nelson, Heather H; Houseman, E Andres; Marsit, Carmen J; Kelsey, Karl T (2012. )Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study.Epigenetics : official journal of the DNA Methylation Society, ,7 (3 ),291-9

Langevin, S. M.; McClean, M. D.; Michaud, D. S.; Eliot, M.; Nelson, H. H.; Kelsey, K. T. (2013. )Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case-control study conducted in the greater Boston area .Cancer Med, ,2 (6 ),978-86

Wilhelm-Benartzi, Charlotte S; Houseman, E Andres; Maccani, Matthew A; Poage, Graham M; Koestler, Devin C; Langevin, Scott M; Gagne, Luc A; Banister, Carolyn E; Padbury, James F; Marsit, Carmen J (2012. )In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta.Environmental health perspectives, ,120 (2 ),296-302

Eliot, M. N.; Michaud, D. S.; Langevin, S. M.; McClean, M. D.; Kelsey, K. T. (2013. )Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma .Cancer Causes Control, ,24 (7 ),1315-22

Langevin, Scott M; Grandis, Jennifer R; Taioli, Emanuela (2011. )Female hormonal and reproductive factors and head and neck squamous cell carcinoma risk.Cancer letters, ,310 (2 ),216-21

Zhou, J.; Michaud, D. S.; Langevin, S. M.; McClean, M. D.; Eliot, M.; Kelsey, K. T. (2013. )Smokeless tobacco and risk of head and neck cancer: evidence from a case-control study in New England .Int J Cancer, ,132 (8 ),1911-7

Ragin, Camille C; Langevin, Scott M; Marzouk, Mark; Grandis, Jennifer; Taioli, Emanuela (2011. )Determinants of head and neck cancer survival by race.Head & neck, ,33 (8 ),1092-8

Langevin, S. M.; Kelsey, K. T. (2013. )The fate is not always written in the genes: epigenomics in epidemiologic studies .Environ Mol Mutagen, ,54 (7 ),533-41

Langevin, Scott M; Houseman, E Andres; Christensen, Brock C; Wiencke, John K; Nelson, Heather H; Karagas, Margaret R; Marsit, Carmen J; Kelsey, Karl T (2011. )The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics : official journal of the DNA Methylation Society, ,6 (7 ),908-19

Langevin, S. M.; Pinney, S. M.; Leung, Y. K.; Ho, S. M. (2014. )Does epigenetic drift contribute to age-related increases in breast cancer risk? .Epigenomics, ,6 (4 ),367-9

Langevin, Scott M; Stone, Roslyn A; Bunker, Clareann H; Lyons-Weiler, Maureen A; LaFramboise, William A; Kelly, Lori; Seethala, Raja R; Grandis, Jennifer R; Sobol, Robert W; Taioli, Emanuela (2011. )MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck.Cancer, ,117 (7 ),1454-62

Michaud, D. S.; Langevin, S. M.; Eliot, M.; Nelson, H. H.; Pawlita, M.; McClean, M. D.; Kelsey, K. T. (2014. )High-risk HPV types and head and neck cancer .Int J Cancer, ,135 (7 ),1653-61

Langevin, Scott M; Ioannidis, John P A; Vineis, Paolo; Taioli, Emanuela (2010. )Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines.Pharmacogenetics and genomics, ,20 (10 ),586-97

Langevin, S. M.; Christensen, B. C. (2014. )Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis .Cancer Med, ,3 (5 ),1385-95

Langevin, Scott M; Stone, Roslyn A; Bunker, Clareann H; Grandis, Jennifer R; Sobol, Robert W; Taioli, Emanuela (2010. )MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index.Carcinogenesis, ,31 (5 ),864-70

Langevin, S. M.; Houseman, E. A.; Accomando, W. P.; Koestler, D. C.; Christensen, B. C.; Nelson, H. H.; Karagas, M. R.; Marsit, C. J.; Wiencke, J. K.; Kelsey, K. T. (2014. )Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients .Epigenetics, ,9 (6 ),884-95

Kwok, Joseph; Langevin, Scott M; Argiris, Athanassios; Grandis, Jennifer R; Gooding, William E; Taioli, Emanuela (2010. )The impact of health insurance status on the survival of patients with head and neck cancer.Cancer, ,116 (2 ),476-85

Langevin, S. M.; Butler, R. A.; Eliot, M.; Pawlita, M.; Maccani, J. Z.; McClean, M. D.; Kelsey, K. T. (2014. )Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma .Oral Oncol, ,50 (11 ),1072-80

Ragin, Camille C; Langevin, Scott; Rubin, Scott; Taioli, Emanuela (2010. )Review of studies on metabolic genes and cancer in populations of African descent.Genetics in medicine : official journal of the American College of Medical Genetics, ,12 (1 ),12-8

Langevin, S. M.; Eliot, M.; Butler, R. A.; Cheong, A.; Zhang, X.; McClean, M. D.; Koestler, D. C.; Kelsey, K. T. (2015. )CpG island methylation profile in non-invasive oral rinse samples is predictive of oral and pharyngeal carcinoma .Clin Epigenetics, ,7 (5 ),125

Taioli, Emanuela; Ragin, Camille; Wang, Xiao-Hong; Chen, Jiangying; Langevin, Scott M; Brown, Ashley R; Gollin, Susanne M; Garte, Seymour; Sobol, Robert W (2009. )Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation.BMC cancer, ,9 ,354

Langevin, S. M.; Kratzke, R. A.; Kelsey, K. T. (2015. )Epigenetics of lung cancer .Transl Res, ,165 (1 ),74-90

Langevin SM, Lin D, Matsuo K, Gao CM, Takezaki T, Stolzenberg-Solomon RZ, Vasavi M, Hasan Q, Taioli E (2009. )Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer .Toxicol Lett, ,184 (2 ),73 -80

Kelsey, K. T.; Nelson, H. H.; Kim, S.; Pawlita, M.; Langevin, S. M.; Eliot, M.; Michaud, D. S.; McClean, M. (2015. )Human papillomavirus serology and tobacco smoking in a community control group .BMC Infect Dis, ,15 (7 ),8

Langevin, Scott M; Pinney, Susan M; Leung, Yuet-Kin; Ho, Shuk-Mei (2014. )Does epigenetic drift contribute to age-related increases in breast cancer risk?.Epigenomics, ,6 (4 ),367-9

Tan, X.; Nelson, H. H.; Langevin, S. M.; McClean, M.; Marsit, C. J.; Waterboer, T.; Pawlita, M.; Kelsey, K. T.; Michaud, D. S. (2015. )Obesity and head and neck cancer risk and survival by human papillomavirus serology .Cancer Causes Control, ,26 (1 ),111-9

Kelsey KT, Nelson HH, Kim S, Pawlita M, Langevin SM, Eliot M, Michaud DS, McClean M (2015. )Human papillomavirus serology and tobacco smoking in a community control group .BMC Infect Dis, ,15 (1 ),8

Fogleman, E. V.; Eliot, M.; Michaud, D. S.; Nelson, H. H.; McClean, M. D.; Langevin, S. M.; Kelsey, K. T. (2015. )Occupational asphalt is not associated with head and neck cancer .Occup Med (Lond), ,65 (7 ),570-3

Nelson, H. H.; Pawlita, M.; Michaud, D. S.; McClean, M.; Langevin, S. M.; Eliot, M. N.; Kelsey, K. T. (2017. )Immune Response to HPV16 E6 and E7 Proteins and Patient Outcomes in Head and Neck Cancer .JAMA Oncol, ,3 (2 ),178-185

Haque, S. U.; Niu, L.; Kuhnell, D.; Hendershot, J.; Biesiada, J.; Niu, W.; Hagan, M. C.; Kelsey, K. T.; Casper, K. A.; Wise-Draper, T. M.; Medvedovic, M.; Langevin, S. M. (2018. )Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma .Head Neck, ,40 (7 ),1555-1564

Thery, C.; Witwer, K. W.; Aikawa, E.; Alcaraz, M. J.; Anderson, J. D.; Andriantsitohaina, R.; Antoniou, A.; Arab, T.; Archer, F.; Atkin-Smith, G. K.; Ayre, D. C.; Bach, J. M.; Bachurski, D.; Baharvand, H.; Balaj, L.; Baldacchino, S.; Bauer, N. N.; Baxter, A. A.; Bebawy, M.; Beckham, C.; Bedina Zavec, A.; Benmoussa, A.; Berardi, A. C.; Bergese, P.; Bielska, E.; Blenkiron, C.; Bobis-Wozowicz, S.; Boilard, E.; Boireau, W.; Bongiovanni, A.; Borras, F. E.; Bosch, S.; Boulanger, C. M.; Breakefield, X.; Breglio, A. M.; Brennan, M. A.; Brigstock, D. R.; Brisson, A.; Broekman, M. L.; Bromberg, J. F.; Bryl-Gorecka, P.; Buch, S.; Buck, A. H.; Burger, D.; Busatto, S.; Buschmann, D.; Bussolati, B.; Buzas, E. I.; Byrd, J. B.; Camussi, G.; Carter, D. R.; Caruso, S.; Chamley, L. W.; Chang, Y. T.; Chen, C.; Chen, S.; Cheng, L.; Chin, A. R.; Clayton, A.; Clerici, S. P.; Cocks, A.; Cocucci, E.; Coffey, R. J.; Cordeiro-da-Silva, A.; Couch, Y.; Coumans, F. A.; Coyle, B.; Crescitelli, R.; Criado, M. F.; D'Souza-Schorey, C.; Das, S.; Datta Chaudhuri, A.; de Candia, P.; De Santana, E. F.; De Wever, O.; Del Portillo, H. A.; Demaret, T.; Deville, S.; Devitt, A.; Dhondt, B.; Di Vizio, D.; Dieterich, L. C.; Dolo, V.; Dominguez Rubio, A. P.; Dominic (2018. )Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines .J Extracell Vesicles, ,7 (1 ),1535750

Langevin, S. M.; Kuhnell, D.; Orr-Asman, M. A.; Biesiada, J.; Zhang, X.; Medvedovic, M.; Thomas, H. E. (2019. )Balancing yield, purity and practicality: a modified differential ultracentrifugation protocol for efficient isolation of small extracellular vesicles from human serum .RNA Biol, ,16 (1 ),5-12

Langevin, S. M.; Kuhnell, D.; Niu, L.; Biesiada, J.; Leung, Y. K.; Deka, R.; Chen, A.; Medvedovic, M.; Kelsey, K. T.; Kasper, S.; Zhang, X. (2019. )Comprehensive mapping of the methylation landscape of 16 CpG-dense regions in oral and pharyngeal squamous cell carcinoma .Epigenomics, ,165 (1 ),74-90

Wronkiewicz, Stephanie K; Roggli, Victor L; Hinrichs, Benjamin H; Kendler, Ady; Butler, Rondi A; Christensen, Brock C; Marsit, Carmen J; Nelson, Heather H; McClean, Michael D; Kelsey, Karl T; Langevin, Scott M (2019. )Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of occupational asbestos exposure.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, ,

Butler R.; Christensen B.; Hinrichs B.; Kelsey K.; Kendler A.; Langevin S.; Marsit C.; McClean M.; Nelson H.; Roggli V.; Wronkiewicz S. (01-01-2019. )Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of.Modern Pathology, ,

Aikawa E.; Alcaraz M.; Anderson J.; Andriantsitohaina R.; Antoniou A.; Arab T.; Archer F.; Atkin-Smith G.; Ayre D.; Bach J.; Bachurski D.; Baharvand H.; Balaj L.; Baldacchino S.; Bauer N.; Baxter A.; Bebawy M.; Beckham C.; Bedina Zavec A.; Benmoussa A.; Berardi A.; Bergese P.; Bielska E.; Blenkiron C.; Bobis-Wozowicz S.; Boilard E.; Boireau W.; Bongiovanni A.; Borràs F.; Bosch S.; Boulanger C.; Breakefield X.; Breglio A.; Brennan M.; Brigstock D.; Brisson A.; Broekman M.; Bromberg J.; Bryl-Górecka P.; Buch S.; Buck A.; Burger D.; Busatto S.; Buschmann D.; Bussolati B.; Buzás E.; Byrd J.; Camussi G.; Carter D.; Caruso S.; Chamley L.; Chang Y.; Chaudhuri A.; Chen C.; Chen S.; Cheng L.; Chin A.; Clayton A.; Clerici S.; Cocks A.; Cocucci E.; Coffey R.; Cordeiro-da-Silva A.; Couch Y.; Coumans F.; Coyle B.; Crescitelli R.; Criado M.; D’Souza-Schorey C.; Das S.; de Candia P.; De Santana E.; De Wever O.; del Portillo H.; Demaret T.; Deville S.; Devitt A.; Dhondt B.; Di Vizio D.; Dieterich L.; Dolo V.; Dominguez Rubio A.; Dominici M.; Dourado M.; Driedonks T.; Duarte F.; Duncan H.; Eichenberger R.; Ekström K.; EL Andaloussi S.; Elie-Caille C.; Erdbrügger U.; Falcón-Pérez J.; Fatima F.; Fish J.; Flores-Bellver M.; Försönits A.; Frelet-Barrand A.; Théry C.; Witwer K. (01-01-2018. )Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of .Journal of Extracellular Vesicles, ,7 (1 ),

Kelsey K.; Langevin S. (01-04-2017. )Clinical Epigenetics of Lung Cancer.Translating Epigenetics to the Clinic, ,97-133

Biesiada J.; Casper K.; Huang S.; Kasper S.; Kuhnell D.; Langevin S.; Medvedovic M.; Parry T.; Wise-Draper T.; Zhang X. (01-01-2017. )Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro re.Oncotarget, ,8 (47 ),82459-82474

Butler R.; Cheong A.; Eliot M.; Kelsey K.; Koestler D.; Langevin S.; McClean M.; Zhang X. (12-03-2015. )CpG island methylation profile in noninvasive oral rinse samples is predictive of oral and pharyngea.Clinical Epigenetics, ,7 (1 ),

Haynes E.; Langevin S. (01-01-2015. )Developmental effects of manganese .Issues in Toxicology, ,2015-January (22 ),426-436

Eliot M.; Fogleman E.; Kelsey K.; Langevin S.; McClean M.; Michaud D.; Nelson H. (01-01-2015. )Occupational asphalt is not associated with head and neck cancer.Occupational Medicine, ,65 (7 ),570-573

Kelsey K.; Langevin S. (01-01-2014. )Genetics and gene-environment interactions.Occupational Cancers, ,21-31

Kelsey K.; Langevin S. (01-01-2014. )Mechanisms of environmental and occupational carcinogenesis.Occupational Cancers, ,33-48

Andres Houseman E.; Butler R.; Christensen B.; Kelsey K.; Koestler D.; Langevin S.; Marsit C.; Nelson H.; Wiencke J. (01-01-2012. )Peripheral blood DNA Methylation profiles are indicative of head and neck squamous cell carcinoma: A.Epigenetics, ,7 (3 ),291-299

Christensen B.; Houseman E.; Karagas M.; Kelsey K.; Langevin S.; Marsit C.; Nelson H.; Wiencke J. (01-01-2011. )The influence of aging, environmental exposures and local sequence features on the variation of DNA .Epigenetics, ,6 (7 ),908-919

Gao C.; Hasan Q.; Langevin S.; Lin D.; Matsuo K.; Stolzenberg-Solomon R.; Taioli E.; Takezaki T.; Vasavi M. (01-30-2009. )Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer.Toxicology Letters, ,184 (2 ),73-80

Langevin, Scott M; Eliot, Melissa; Butler, Rondi A; McClean, Michael; Kelsey, Karl T (2020. )Firefighter occupation is associated with increased risk for laryngeal and hypopharyngeal squamous cell carcinoma among men from the Greater Boston area.Occupational and environmental medicine, ,

Shi, Leilei; Kuhnell, Damaris; Borra, Vishnupriya J; Langevin, Scott M; Nakamura, Takahisa; Esfandiari, Leyla (2019. )Rapid and label-free isolation of small extracellular vesicles from biofluids utilizing a novel insulator based dielectrophoretic device.Lab on a chip, ,19 (21 ),3726-3734

Invited Publications

Langevin SM, Pinney SM, Leung YK, Ho SM (2014. )Does epigenetic drift contribute to age-related increases in breast cancer risk? .Epigenomics, 6 (4 ),367

Book Chapter

Langevin SM and Kelsey KT (2014 )Genetics and gene-environment interactions (Ch. 2). Occupational Cancer (1st edition) .(pp. 21-31).Springer

Langevin SM and Kelsey KT (2014 )Mechanisms of environmental and occupational carcinogenesis (Ch. 3) Occupational Cancer (1st edition) .(pp. 33-48).Springer

Langevin SM and Haynes EN (2015 )Developmental Effects (Ch. 16) Manganese in Health and Disease .(pp. 426).RSC Publishing

Langevin SM and Kelsey KT (2016 )Clinical Epigenetics of Lung Cancer (Ch. 5) Translating Epigenetics to the Clinic .(pp. 97).Springer

Langevin SM and Kelsey KT (2020 )Genetics, Epigenetics and Environmental Interactions (Ch. 2) Occupational Cancers (2nd edition) .(pp. 21).Springer

Langevin SM and Kelsey KT (2020 )Mechanisms of Environmental and Occupational Carcinogenesis (Ch. 3) Occupational Cancers (2nd edition) .(pp. 39).Springer

Post Graduate Training and Education

2010-2013 Postdoctoral Fellow in Environmental Pathology, Brown University, ,Providence, RI

Keywords

Molecular epidemiology, epigenetics, extracellular vesicles, biomarkers, head and neck cancer, lung cancer

Courses Taught

-BE-9073C MOL EPIDEMIOLOGY Level:Graduate

Patents and Inventions

15/806,148 CpG island methylation profile in non-invasive oral rinse samples for detection of oral and pharyngeal carcinoma Scott M. Langevin and Karl T. Kelsey, Filed Inventor

Contact Information

Academic - Kettering Laboratory
160 Panzeca Way, ML0056
Cincinnati  Ohio, 45267
Phone: (513) 558-1066
langevst@uc.edu