Scott Langevin

Scott M Langevin , PhD,MHA,CT(ASCP)

Associate Professor

Kettering Laboratory
160 Panzeca Way, ML0056
Cincinnati, Ohio 45267
Phone (513) 558-1066
Email langevst@uc.edu

Professional Summary

My area of expertise is the molecular epidemiology of cancer, primarily for malignancies originating in the upper aerodigestive tract. My research interests include cancer-associated epigenetic alterations, genetic/epigenetic-environment interactions, identification and evaluation of diagnostic and prognostic biomarkers, and the epidemiology of head and neck cancer.

Education

Bachelor's Degree: Siena College Loudonville, NY, 1999 (Biology)

Master's Degree: Quinnipiac University Hamden, CT, 2005

Doctoral Degree: University of Pittsburgh Graduate School of Public Health Pittsburgh, PA, 2010 (Epidemiology)

Postdoctoral Fellowship: Brown University Providence, RI, 2013 ( Environmental Pathology )

Positions and Work Experience

2010 -2013 Postdoctoral Research Fellow, Brown University, Providence, RI

2013 -2019 Assistant Professor of Epidemiology, University of Cincinnati College of Medicine, Cincinnati, OH

2019 -To Present Associate Professor of Epidemiology, University of Cincinnati College of Medicine,

Research Support

Grant: #K22CA172358 Investigators:Langevin, Scott 09-25-2013 -08-31-2016 National Cancer Institute Epigenetic alterations in oral rinse as biomarkers of oral and pharyngeal cancer Role:PI $103,107.00 Awarded Level:Federal

Grant: #SRS 009255 Investigators:Casper, Keith; Langevin, Scott 07-01-2014 -07-01-2015 Brandon C. Gromada Head and Neck Cancer Foundation A Comprehensive Study of Common Mutations in Sinonasal Cancer Role:PI $15,000.00 Awarded Level:Private Non-Profit

Grant: #Check 3567 Investigators:Langevin, Scott; Wise-Draper, Trisha; Zhang, Xiang 01-01-2016 -12-31-2016 Elsa U. Pardee Foundation Targeted Mutation Sequencing to Predict Definitive Chemoradiation Response for Head and Neck Cancer Role:PI $168,947.00 Awarded Level:Private Non-Profit

Grant: #Gromada Investigators:Langevin, Scott; Wise-Draper, Trisha 07-01-2016 -06-30-2017 Brandon C. Gromada Head and Neck Cancer Foundation Efficacy of an LSD1 Inhibitor (GSK2879552) for Treating Sinonasal Squamous Cancer Role:PI $20,000.00 Active Level:Private Non-Profit

Grant: #R56 HL128493 Investigators:Chen, Aimin; Deka, Ranjan; Langevin, Scott; Leung, Yuet Kin; Medvedovic, Mario 09-19-2016 -08-31-2017 National Heart, Lung and Blood Institute Integrated GWAS and EWAS of Cardiometabolic Traits in an Island Population Role:Collaborator $677,923.00 Active Level:Federal

Grant: #R21DE027227 Investigators:Kasper, Susan; Langevin, Scott; Medvedovic, Mario; Wise-Draper, Trisha; Zhang, Xiang 09-01-2017 -08-31-2019 National Institute of Dental and Craniofacial Research Exosomal miRNA as Salivary Biomarkers for HPV+ Head and Neck Carcinoma Role:PI $239,250.00 Awarded Level:Federal

Grant: #RSG-18-148-01-CCE Investigators:Langevin, Scott 01-01-2019 -12-31-2022 American Cancer Society - National Chapter Oral Rinse Methylation for Follow-Up Surveillance of Oral/Pharyngeal Cancer Role:PI $782,000.00 Awarded Level:Private Non-Profit

Publications

Peer Reviewed Publications

Tan, Xinmiao; Nelson, Heather H; Langevin, Scott M; McClean, Michael; Marsit, Carmen J; Waterboer, Tim; Pawlita, Michael; Kelsey, Karl T; Michaud, Dominique S (2014. ) Obesity and head and neck cancer risk and survival by human papillomavirus serology.Cancer causes & control : CCC, , More Information

Taioli, E.; Ragin, C.; Wang, X. H.; Chen, J.; Langevin, S. M.; Brown, A. R.; Gollin, S. M.; Garte, S.; Sobol, R. W. (2009. ) Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation .BMC Cancer, , 9 (8 ) ,354

Langevin, Scott M; Christensen, Brock C (2014. ) Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis.Cancer medicine, , 3 (5 ) ,1385-95 More Information

Langevin, S. M.; Lin, D.; Matsuo, K.; Gao, C. M.; Takezaki, T.; Stolzenberg-Solomon, R. Z.; Vasavi, M.; Hasan, Q.; Taioli, E. (2009. ) Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer .Toxicol Lett, , 184 (2 ) ,73-80

Michaud, Dominique S; Langevin, Scott M; Eliot, Melissa; Nelson, Heather H; Pawlita, Michael; McClean, Michael D; Kelsey, Karl T (2014. ) High-risk HPV types and head and neck cancer.International journal of cancer. Journal international du cancer, , 135 (7 ) ,1653-61 More Information

Langevin, S. M.; Ioannidis, J. P.; Vineis, P.; Taioli, E.; Genetic Susceptibility to Environmental Carcinogens, group (2010. ) Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines .Pharmacogenet Genomics, , 20 (10 ) ,586-97

Langevin, Scott M; Butler, Rondi A; Eliot, Melissa; Pawlita, Michael; Maccani, Jennifer Z J; McClean, Michael D; Kelsey, Karl T (2014. ) Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma.Oral oncology, , More Information

Langevin, S. M.; Stone, R. A.; Bunker, C. H.; Grandis, J. R.; Sobol, R. W.; Taioli, E. (2010. ) MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index .Carcinogenesis, , 31 (5 ) ,864-70

Kwok, J.; Langevin, S. M.; Argiris, A.; Grandis, J. R.; Gooding, W. E.; Taioli, E. (2010. ) The impact of health insurance status on the survival of patients with head and neck cancer .Cancer, , 116 (2 ) ,476-85

Langevin, Scott M; Houseman, E Andres; Accomando, William P; Koestler, Devin C; Christensen, Brock C; Nelson, Heather H; Karagas, Margaret R; Marsit, Carmen J; Wiencke, John K; Kelsey, Karl T (2014. ) Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.Epigenetics : official journal of the DNA Methylation Society, , 9 (6 ) ,884-95 More Information

Ragin, C. C.; Langevin, S. M.; Marzouk, M.; Grandis, J.; Taioli, E. (2011. ) Determinants of head and neck cancer survival by race .Head Neck, , 33 (8 ) ,1092-8

Langevin, Scott M; Kratzke, Robert A; Kelsey, Karl T (2014. ) Epigenetics of lung cancer.Translational research : the journal of laboratory and clinical medicine, , More Information

Langevin, S. M.; Grandis, J. R.; Taioli, E. (2011. ) Female hormonal and reproductive factors and head and neck squamous cell carcinoma risk .Cancer Lett, , 310 (2 ) ,216-21

Langevin, Scott M; McClean, Michael D; Michaud, Dominique S; Eliot, Melissa; Nelson, Heather H; Kelsey, Karl T (2013. ) Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case-control study conducted in the greater Boston area.Cancer medicine, , 2 (6 ) ,978-86 More Information

Langevin, S. M.; Stone, R. A.; Bunker, C. H.; Lyons-Weiler, M. A.; LaFramboise, W. A.; Kelly, L.; Seethala, R. R.; Grandis, J. R.; Sobol, R. W.; Taioli, E. (2011. ) MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck .Cancer, , 117 (7 ) ,1454-62

Langevin, Scott M; O'Sullivan, Mattie H; Valerio, Jennifer L; Pawlita, Michael; Applebaum, Katie M; Eliot, Melissa; McClean, Michael D; Kelsey, Karl T (2013. ) Occupational asbestos exposure is associated with pharyngeal squamous cell carcinoma in men from the greater Boston area.Occupational and environmental medicine, , 70 (12 ) ,858-63 More Information

Langevin, S. M.; Houseman, E. A.; Christensen, B. C.; Wiencke, J. K.; Nelson, H. H.; Karagas, M. R.; Marsit, C. J.; Kelsey, K. T. (2011. ) The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood .Epigenetics, , 6 (7 ) ,908-19

Langevin, Scott M; Kelsey, Karl T (2013. ) The fate is not always written in the genes: epigenomics in epidemiologic studies.Environmental and molecular mutagenesis, , 54 (7 ) ,533-41 More Information

Michaud, D. S.; Langevin, S. M.; Eliot, M.; Nelson, H. H.; McClean, M. D.; Christensen, B. C.; Marsit, C. J.; Kelsey, K. T. (2012. ) Allergies and risk of head and neck cancer .Cancer Causes Control, , 23 (8 ) ,1317-22

Koestler, Devin C; Christensen, Brock; Karagas, Margaret R; Marsit, Carmen J; Langevin, Scott M; Kelsey, Karl T; Wiencke, John K; Houseman, E Andres (2013. ) Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis.Epigenetics : official journal of the DNA Methylation Society, , 8 (8 ) ,816-26 More Information

Wilhelm-Benartzi, C. S.; Houseman, E. A.; Maccani, M. A.; Poage, G. M.; Koestler, D. C.; Langevin, S. M.; Gagne, L. A.; Banister, C. E.; Padbury, J. F.; Marsit, C. J. (2012. ) In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta .Environ Health Perspect, , 120 (2 ) ,296-302

Eliot, Melissa N; Michaud, Dominique S; Langevin, Scott M; McClean, Michael D; Kelsey, Karl T (2013. ) Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma.Cancer causes & control : CCC, , 24 (7 ) ,1315-22 More Information

Langevin, S. M.; Koestler, D. C.; Christensen, B. C.; Butler, R. A.; Wiencke, J. K.; Nelson, H. H.; Houseman, E. A.; Marsit, C. J.; Kelsey, K. T. (2012. ) Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study .Epigenetics, , 7 (3 ) ,291-9

Langevin, Scott M; Michaud, Dominique S; Marsit, Carmen J; Nelson, Heather H; Birnbaum, Ariel E; Eliot, Melissa; Christensen, Brock C; McClean, Michael D; Kelsey, Karl T (2013. ) Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , 22 (6 ) ,1061-8 More Information

Koestler, D. C.; Marsit, C. J.; Christensen, B. C.; Accomando, W.; Langevin, S. M.; Houseman, E. A.; Nelson, H. H.; Karagas, M. R.; Wiencke, J. K.; Kelsey, K. T. (2012. ) Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers .Cancer Epidemiol Biomarkers Prev, , 21 (8 ) ,1293-302

Zhou, Jiachen; Michaud, Dominique S; Langevin, Scott M; McClean, Michael D; Eliot, Melissa; Kelsey, Karl T (2013. ) Smokeless tobacco and risk of head and neck cancer: evidence from a case-control study in New England.International journal of cancer. Journal international du cancer, , 132 (8 ) ,1911-7 More Information

Langevin, S. M.; Michaud, D. S.; Eliot, M.; Peters, E. S.; McClean, M. D.; Kelsey, K. T. (2012. ) Regular dental visits are associated with earlier stage at diagnosis for oral and pharyngeal cancer .Cancer Causes Control, , 23 (11 ) ,1821-9

Langevin, Scott M; Michaud, Dominique S; Eliot, Melissa; Peters, Edward S; McClean, Michael D; Kelsey, Karl T (2012. ) Regular dental visits are associated with earlier stage at diagnosis for oral and pharyngeal cancer.Cancer causes & control : CCC, , 23 (11 ) ,1821-9 More Information

Koestler, D. C.; Christensen, B.; Karagas, M. R.; Marsit, C. J.; Langevin, S. M.; Kelsey, K. T.; Wiencke, J. K.; Houseman, E. A. (2013. ) Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis .Epigenetics, , 8 (8 ) ,816-26

Michaud, Dominique S; Langevin, Scott M; Eliot, Melissa; Nelson, Heather H; McClean, Michael D; Christensen, Brock C; Marsit, Carmen J; Kelsey, Karl T (2012. ) Allergies and risk of head and neck cancer.Cancer causes & control : CCC, , 23 (8 ) ,1317-22 More Information

Langevin, S. M.; Michaud, D. S.; Marsit, C. J.; Nelson, H. H.; Birnbaum, A. E.; Eliot, M.; Christensen, B. C.; McClean, M. D.; Kelsey, K. T. (2013. ) Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma .Cancer Epidemiol Biomarkers Prev, , 22 (6 ) ,1061-8

Koestler, Devin C; Marsit, Carmen J; Christensen, Brock C; Accomando, William; Langevin, Scott M; Houseman, E Andres; Nelson, Heather H; Karagas, Margaret R; Wiencke, John K; Kelsey, Karl T (2012. ) Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, , 21 (8 ) ,1293-302 More Information

Langevin, S. M.; O'Sullivan, M. H.; Valerio, J. L.; Pawlita, M.; Applebaum, K. M.; Eliot, M.; McClean, M. D.; Kelsey, K. T. (2013. ) Occupational asbestos exposure is associated with pharyngeal squamous cell carcinoma in men from the greater Boston area .Occup Environ Med, , 70 (12 ) ,858-63

Langevin, Scott M; Koestler, Devin C; Christensen, Brock C; Butler, Rondi A; Wiencke, John K; Nelson, Heather H; Houseman, E Andres; Marsit, Carmen J; Kelsey, Karl T (2012. ) Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study.Epigenetics : official journal of the DNA Methylation Society, , 7 (3 ) ,291-9 More Information

Langevin, S. M.; McClean, M. D.; Michaud, D. S.; Eliot, M.; Nelson, H. H.; Kelsey, K. T. (2013. ) Occupational dust exposure and head and neck squamous cell carcinoma risk in a population-based case-control study conducted in the greater Boston area .Cancer Med, , 2 (6 ) ,978-86

Wilhelm-Benartzi, Charlotte S; Houseman, E Andres; Maccani, Matthew A; Poage, Graham M; Koestler, Devin C; Langevin, Scott M; Gagne, Luc A; Banister, Carolyn E; Padbury, James F; Marsit, Carmen J (2012. ) In utero exposures, infant growth, and DNA methylation of repetitive elements and developmentally related genes in human placenta.Environmental health perspectives, , 120 (2 ) ,296-302 More Information

Eliot, M. N.; Michaud, D. S.; Langevin, S. M.; McClean, M. D.; Kelsey, K. T. (2013. ) Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma .Cancer Causes Control, , 24 (7 ) ,1315-22

Langevin, Scott M; Grandis, Jennifer R; Taioli, Emanuela (2011. ) Female hormonal and reproductive factors and head and neck squamous cell carcinoma risk.Cancer letters, , 310 (2 ) ,216-21 More Information

Zhou, J.; Michaud, D. S.; Langevin, S. M.; McClean, M. D.; Eliot, M.; Kelsey, K. T. (2013. ) Smokeless tobacco and risk of head and neck cancer: evidence from a case-control study in New England .Int J Cancer, , 132 (8 ) ,1911-7

Ragin, Camille C; Langevin, Scott M; Marzouk, Mark; Grandis, Jennifer; Taioli, Emanuela (2011. ) Determinants of head and neck cancer survival by race.Head & neck, , 33 (8 ) ,1092-8 More Information

Langevin, S. M.; Kelsey, K. T. (2013. ) The fate is not always written in the genes: epigenomics in epidemiologic studies .Environ Mol Mutagen, , 54 (7 ) ,533-41

Langevin, Scott M; Houseman, E Andres; Christensen, Brock C; Wiencke, John K; Nelson, Heather H; Karagas, Margaret R; Marsit, Carmen J; Kelsey, Karl T (2011. ) The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics : official journal of the DNA Methylation Society, , 6 (7 ) ,908-19

Langevin, S. M.; Pinney, S. M.; Leung, Y. K.; Ho, S. M. (2014. ) Does epigenetic drift contribute to age-related increases in breast cancer risk? .Epigenomics, , 6 (4 ) ,367-9

Langevin, Scott M; Stone, Roslyn A; Bunker, Clareann H; Lyons-Weiler, Maureen A; LaFramboise, William A; Kelly, Lori; Seethala, Raja R; Grandis, Jennifer R; Sobol, Robert W; Taioli, Emanuela (2011. ) MicroRNA-137 promoter methylation is associated with poorer overall survival in patients with squamous cell carcinoma of the head and neck.Cancer, , 117 (7 ) ,1454-62 More Information

Michaud, D. S.; Langevin, S. M.; Eliot, M.; Nelson, H. H.; Pawlita, M.; McClean, M. D.; Kelsey, K. T. (2014. ) High-risk HPV types and head and neck cancer .Int J Cancer, , 135 (7 ) ,1653-61

Langevin, Scott M; Ioannidis, John P A; Vineis, Paolo; Taioli, Emanuela (2010. ) Assessment of cumulative evidence for the association between glutathione S-transferase polymorphisms and lung cancer: application of the Venice interim guidelines.Pharmacogenetics and genomics, , 20 (10 ) ,586-97 More Information

Langevin, S. M.; Christensen, B. C. (2014. ) Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis .Cancer Med, , 3 (5 ) ,1385-95

Langevin, Scott M; Stone, Roslyn A; Bunker, Clareann H; Grandis, Jennifer R; Sobol, Robert W; Taioli, Emanuela (2010. ) MicroRNA-137 promoter methylation in oral rinses from patients with squamous cell carcinoma of the head and neck is associated with gender and body mass index.Carcinogenesis, , 31 (5 ) ,864-70 More Information

Langevin, S. M.; Houseman, E. A.; Accomando, W. P.; Koestler, D. C.; Christensen, B. C.; Nelson, H. H.; Karagas, M. R.; Marsit, C. J.; Wiencke, J. K.; Kelsey, K. T. (2014. ) Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients .Epigenetics, , 9 (6 ) ,884-95

Kwok, Joseph; Langevin, Scott M; Argiris, Athanassios; Grandis, Jennifer R; Gooding, William E; Taioli, Emanuela (2010. ) The impact of health insurance status on the survival of patients with head and neck cancer.Cancer, , 116 (2 ) ,476-85 More Information

Langevin, S. M.; Butler, R. A.; Eliot, M.; Pawlita, M.; Maccani, J. Z.; McClean, M. D.; Kelsey, K. T. (2014. ) Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma .Oral Oncol, , 50 (11 ) ,1072-80

Ragin, Camille C; Langevin, Scott; Rubin, Scott; Taioli, Emanuela (2010. ) Review of studies on metabolic genes and cancer in populations of African descent.Genetics in medicine : official journal of the American College of Medical Genetics, , 12 (1 ) ,12-8 More Information

Langevin, S. M.; Eliot, M.; Butler, R. A.; Cheong, A.; Zhang, X.; McClean, M. D.; Koestler, D. C.; Kelsey, K. T. (2015. ) CpG island methylation profile in non-invasive oral rinse samples is predictive of oral and pharyngeal carcinoma .Clin Epigenetics, , 7 (5 ) ,125

Taioli, Emanuela; Ragin, Camille; Wang, Xiao-Hong; Chen, Jiangying; Langevin, Scott M; Brown, Ashley R; Gollin, Susanne M; Garte, Seymour; Sobol, Robert W (2009. ) Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation.BMC cancer, , 9 ,354 More Information

Langevin, S. M.; Kratzke, R. A.; Kelsey, K. T. (2015. ) Epigenetics of lung cancer .Transl Res, , 165 (1 ) ,74-90

Langevin SM, Lin D, Matsuo K, Gao CM, Takezaki T, Stolzenberg-Solomon RZ, Vasavi M, Hasan Q, Taioli E (2009. ) Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer .Toxicol Lett, , 184 (2 ) ,73 -80

Kelsey, K. T.; Nelson, H. H.; Kim, S.; Pawlita, M.; Langevin, S. M.; Eliot, M.; Michaud, D. S.; McClean, M. (2015. ) Human papillomavirus serology and tobacco smoking in a community control group .BMC Infect Dis, , 15 (7 ) ,8

Langevin, Scott M; Pinney, Susan M; Leung, Yuet-Kin; Ho, Shuk-Mei (2014. ) Does epigenetic drift contribute to age-related increases in breast cancer risk?.Epigenomics, , 6 (4 ) ,367-9 More Information

Tan, X.; Nelson, H. H.; Langevin, S. M.; McClean, M.; Marsit, C. J.; Waterboer, T.; Pawlita, M.; Kelsey, K. T.; Michaud, D. S. (2015. ) Obesity and head and neck cancer risk and survival by human papillomavirus serology .Cancer Causes Control, , 26 (1 ) ,111-9

Kelsey KT, Nelson HH, Kim S, Pawlita M, Langevin SM, Eliot M, Michaud DS, McClean M (2015. ) Human papillomavirus serology and tobacco smoking in a community control group .BMC Infect Dis, , 15 (1 ) ,8

Fogleman, E. V.; Eliot, M.; Michaud, D. S.; Nelson, H. H.; McClean, M. D.; Langevin, S. M.; Kelsey, K. T. (2015. ) Occupational asphalt is not associated with head and neck cancer .Occup Med (Lond), , 65 (7 ) ,570-3

Nelson, H. H.; Pawlita, M.; Michaud, D. S.; McClean, M.; Langevin, S. M.; Eliot, M. N.; Kelsey, K. T. (2017. ) Immune Response to HPV16 E6 and E7 Proteins and Patient Outcomes in Head and Neck Cancer .JAMA Oncol, , 3 (2 ) ,178-185

Haque, S. U.; Niu, L.; Kuhnell, D.; Hendershot, J.; Biesiada, J.; Niu, W.; Hagan, M. C.; Kelsey, K. T.; Casper, K. A.; Wise-Draper, T. M.; Medvedovic, M.; Langevin, S. M. (2018. ) Differential expression and prognostic value of long non-coding RNA in HPV-negative head and neck squamous cell carcinoma .Head Neck, , 40 (7 ) ,1555-1564

Thery, C.; Witwer, K. W.; Aikawa, E.; Alcaraz, M. J.; Anderson, J. D.; Andriantsitohaina, R.; Antoniou, A.; Arab, T.; Archer, F.; Atkin-Smith, G. K.; Ayre, D. C.; Bach, J. M.; Bachurski, D.; Baharvand, H.; Balaj, L.; Baldacchino, S.; Bauer, N. N.; Baxter, A. A.; Bebawy, M.; Beckham, C.; Bedina Zavec, A.; Benmoussa, A.; Berardi, A. C.; Bergese, P.; Bielska, E.; Blenkiron, C.; Bobis-Wozowicz, S.; Boilard, E.; Boireau, W.; Bongiovanni, A.; Borras, F. E.; Bosch, S.; Boulanger, C. M.; Breakefield, X.; Breglio, A. M.; Brennan, M. A.; Brigstock, D. R.; Brisson, A.; Broekman, M. L.; Bromberg, J. F.; Bryl-Gorecka, P.; Buch, S.; Buck, A. H.; Burger, D.; Busatto, S.; Buschmann, D.; Bussolati, B.; Buzas, E. I.; Byrd, J. B.; Camussi, G.; Carter, D. R.; Caruso, S.; Chamley, L. W.; Chang, Y. T.; Chen, C.; Chen, S.; Cheng, L.; Chin, A. R.; Clayton, A.; Clerici, S. P.; Cocks, A.; Cocucci, E.; Coffey, R. J.; Cordeiro-da-Silva, A.; Couch, Y.; Coumans, F. A.; Coyle, B.; Crescitelli, R.; Criado, M. F.; D'Souza-Schorey, C.; Das, S.; Datta Chaudhuri, A.; de Candia, P.; De Santana, E. F.; De Wever, O.; Del Portillo, H. A.; Demaret, T.; Deville, S.; Devitt, A.; Dhondt, B.; Di Vizio, D.; Dieterich, L. C.; Dolo, V.; Dominguez Rubio, A. P.; Dominic (2018. ) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines .J Extracell Vesicles, , 7 (1 ) ,1535750

Langevin, S. M.; Kuhnell, D.; Orr-Asman, M. A.; Biesiada, J.; Zhang, X.; Medvedovic, M.; Thomas, H. E. (2019. ) Balancing yield, purity and practicality: a modified differential ultracentrifugation protocol for efficient isolation of small extracellular vesicles from human serum .RNA Biol, , 16 (1 ) ,5-12

Langevin, S. M.; Kuhnell, D.; Niu, L.; Biesiada, J.; Leung, Y. K.; Deka, R.; Chen, A.; Medvedovic, M.; Kelsey, K. T.; Kasper, S.; Zhang, X. (2019. ) Comprehensive mapping of the methylation landscape of 16 CpG-dense regions in oral and pharyngeal squamous cell carcinoma .Epigenomics, , 165 (1 ) ,74-90

Wronkiewicz, Stephanie K; Roggli, Victor L; Hinrichs, Benjamin H; Kendler, Ady; Butler, Rondi A; Christensen, Brock C; Marsit, Carmen J; Nelson, Heather H; McClean, Michael D; Kelsey, Karl T; Langevin, Scott M (2019. ) Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of occupational asbestos exposure.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, , More Information

Wronkiewicz S.K.;Roggli V.L.;Hinrichs B.H.;Kendler A.;Butler R.A.;Christensen B.C.;Marsit C.J.;Nelson H.H.;McClean M.D.;Kelsey K.T.;Langevin S.M. (01-01-2019. ) Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of.Modern Pathology, , More Information

Théry C.;Witwer K.W.;Aikawa E.;Alcaraz M.J.;Anderson J.D.;Andriantsitohaina R.;Antoniou A.;Arab T.;Archer F.;Atkin-Smith G.K.;Ayre D.C.;Bach J.M.;Bachurski D.;Baharvand H.;Balaj L.;Baldacchino S.;Bauer N.N.;Baxter A.A.;Bebawy M.;Beckham C.;Bedina Zavec A.;Benmoussa A.;Berardi A.C.;Bergese P.;Bielska E.;Blenkiron C.;Bobis-Wozowicz S.;Boilard E.;Boireau W.;Bongiovanni A.;Borràs F.E.;Bosch S.;Boulanger C.M.;Breakefield X.;Breglio A.M.;Brennan M.;Brigstock D.R.;Brisson A.;Broekman M.L.D.;Bromberg J.F.;Bryl-Górecka P.;Buch S.;Buck A.H.;Burger D.;Busatto S.;Buschmann D.;Bussolati B.;Buzás E.I.;Byrd J.B.;Camussi G.;Carter D.R.F.;Caruso S.;Chamley L.W.;Chang Y.T.;Chaudhuri A.D.;Chen C.;Chen S.;Cheng L.;Chin A.R.;Clayton A.;Clerici S.P.;Cocks A.;Cocucci E.;Coffey R.J.;Cordeiro-da-Silva A.;Couch Y.;Coumans F.A.W.;Coyle B.;Crescitelli R.;Criado M.F.;D’Souza-Schorey C.;Das S.;de Candia P.;De Santana E.F.;De Wever O.;del Portillo H.A.;Demaret T.;Deville S.;Devitt A.;Dhondt B.;Di Vizio D.;Dieterich L.C.;Dolo V.;Dominguez Rubio A.P.;Dominici M.;Dourado M.R.;Driedonks T.A.P.;Duarte F.V.;Duncan H.M.;Eichenberger R.M.;Ekström K.;EL Andaloussi S.;Elie-Caille C.;Erdbrügger U.;Falcón-Pérez J.M.;Fatima F.;Fish J.E.;Flores-Bellver M.;Försönits A.;Frelet-Barrand A. (01-01-2018. ) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of .Journal of Extracellular Vesicles, , 7 (1 ) , More Information

Langevin S.M.;Kelsey K.T. (01-04-2017. ) Clinical Epigenetics of Lung Cancer.Translating Epigenetics to the Clinic, , 97-133 More Information

Langevin S.;Kuhnell D.;Parry T.;Biesiada J.;Huang S.;Wise-Draper T.;Casper K.;Zhang X.;Medvedovic M.;Kasper S. (01-01-2017. ) Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro re.Oncotarget, , 8 (47 ) ,82459-82474 More Information

Langevin S.M.;Eliot M.;Butler R.A.;Cheong A.;Zhang X.;McClean M.D.;Koestler D.C.;Kelsey K.T. (12-03-2015. ) CpG island methylation profile in noninvasive oral rinse samples is predictive of oral and pharyngea.Clinical Epigenetics, , 7 (1 ) , More Information

Langevin S.M.;Haynes E.N. (01-01-2015. ) Developmental effects of manganese .Issues in Toxicology, , 2015-January (22 ) ,426-436

Fogleman E.V.;Eliot M.;Michaud D.S.;Nelson H.H.;McClean M.D.;Langevin S.M.;Kelsey K.T. (01-01-2015. ) Occupational asphalt is not associated with head and neck cancer.Occupational Medicine, , 65 (7 ) ,570-573 More Information

Langevin S.;Kelsey K. (01-01-2014. ) Genetics and gene-environment interactions.Occupational Cancers, , 21-31 More Information

Langevin S.;Kelsey K. (01-01-2014. ) Mechanisms of environmental and occupational carcinogenesis.Occupational Cancers, , 33-48 More Information

Langevin S.M.;Koestler D.C.;Christensen B.C.;Butler R.A.;Wiencke J.K.;Nelson H.H.;Andres Houseman E.;Marsit C.J.;Kelsey K.T. (01-01-2012. ) Peripheral blood DNA Methylation profiles are indicative of head and neck squamous cell carcinoma: A.Epigenetics, , 7 (3 ) ,291-299 More Information

Langevin S.M.;Houseman E.A.;Christensen B.C.;Wiencke J.K.;Nelson H.H.;Karagas M.R.;Marsit C.J.;Kelsey K.T. (01-01-2011. ) The influence of aging, environmental exposures and local sequence features on the variation of DNA .Epigenetics, , 6 (7 ) ,908-919 More Information

Langevin S.M.;Lin D.;Matsuo K.;Gao C.M.;Takezaki T.;Stolzenberg-Solomon R.Z.;Vasavi M.;Hasan Q.;Taioli E. (01-30-2009. ) Review and pooled analysis of studies on MTHFR C677T polymorphism and esophageal cancer.Toxicology Letters, , 184 (2 ) ,73-80 More Information

Langevin, Scott M; Eliot, Melissa; Butler, Rondi A; McClean, Michael; Kelsey, Karl T (2020. ) Firefighter occupation is associated with increased risk for laryngeal and hypopharyngeal squamous cell carcinoma among men from the Greater Boston area.Occupational and environmental medicine, , More Information

Shi, Leilei; Kuhnell, Damaris; Borra, Vishnupriya J; Langevin, Scott M; Nakamura, Takahisa; Esfandiari, Leyla (2019. ) Rapid and label-free isolation of small extracellular vesicles from biofluids utilizing a novel insulator based dielectrophoretic device.Lab on a chip, , 19 (21 ) ,3726-3734 More Information

Invited Publications

Langevin SM, Pinney SM, Leung YK, Ho SM (2014. ) Does epigenetic drift contribute to age-related increases in breast cancer risk? .Epigenomics, 6 (4 ) ,367

Book Chapter

Langevin SM and Kelsey KT (2014 ) Genetics and gene-environment interactions (Ch. 2). Occupational Cancer (1st edition) .(pp. 21 -31).Springer

Langevin SM and Kelsey KT (2014 ) Mechanisms of environmental and occupational carcinogenesis (Ch. 3) Occupational Cancer (1st edition) .(pp. 33 -48).Springer

Langevin SM and Haynes EN (2015 ) Developmental Effects (Ch. 16) Manganese in Health and Disease .(pp. 426).RSC Publishing

Langevin SM and Kelsey KT (2016 ) Clinical Epigenetics of Lung Cancer (Ch. 5) Translating Epigenetics to the Clinic .(pp. 97).Springer

Langevin SM and Kelsey KT (2020 ) Genetics, Epigenetics and Environmental Interactions (Ch. 2) Occupational Cancers (2nd edition) .(pp. 21).Springer

Langevin SM and Kelsey KT (2020 ) Mechanisms of Environmental and Occupational Carcinogenesis (Ch. 3) Occupational Cancers (2nd edition) .(pp. 39).Springer

Keywords

Molecular epidemiology, epigenetics, extracellular vesicles, biomarkers, head and neck cancer, lung cancer

Courses Taught

-BE-9073C MOL EPIDEMIOLOGY Level:Graduate

Patents and Inventions

15/806,148 CpG island methylation profile in non-invasive oral rinse samples for detection of oral and pharyngeal carcinoma Scott M. Langevin and Karl T. Kelsey, Filed Inventor

Contact Information

Academic - Kettering Laboratory
160 Panzeca Way, ML0056
Cincinnati  Ohio, 45267
Phone: (513) 558-1066
langevst@uc.edu