Vanessa Nomellini

Vanessa Nomellini , MD, PhD

Associate Professor of Clinical

Surgical Research Unit

COM Surgery Trauma & Critical Care - 0558

Education

Bachelor's Degree: DePaul University 2003

Medical Degree: Loyola University 2010

Doctoral Degree: Loyola University 2010 (Biochemistry)

General Surgery Residency: University of Wisconsin 2015

Critical Care Fellowship: University of Pennsylvania 2016

Certifications

American Board of Surgery (Surgery Critical Care) (Certification Date: 09-12-2016 )

American Board of Surgery (Certification Date: 11-16-2015 )

Clinical Interests

Critical Care Surgery

General Surgery

Specialities

Surgery-Critical Care

Research Support

Grant: #AAST 2017 Investigators:Nomellini, Vanessa 07-01-2017 -06-30-2018 American Association for the Surgery of Trauma The Role of Sphingosine in the Susceptibility of Pneumonia in the Elderly Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #K08GM131284 Investigators:Nomellini, Vanessa 09-20-2018 -08-31-2023 National Institute of General Medical Sciences Mechanisms of Altered Neutrophil Trafficking in the Persistent Inflammation, Immunosuppression, Catabolism Syndrome Role:PI $199,566.00 Active Level:Federal

Grant: #85219-CIN-17 Investigators:Caldwell, Charles; Gulbins, Erich; Nomellini, Vanessa 01-01-2020 -12-31-2022 Shriners Hospitals for Children - Cincinnati Ceramide regulatory role upon neutrophil chemotaxis after burn injury Role:Collaborator $249,873.00 Active Level:Private Non-Profit

Grant: #R35GM138020 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-01-2020 -06-30-2025 National Institute of General Medical Sciences Utilizing Immune Phenotypes to Prevent Chronic Critical Illness Role:PI $401,250.00 Awarded Level:Federal

Grant: #SUB00002421 / R01GM139046 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-05-2020 -06-30-2025 National Institute of General Medical Sciences Stratifying Patient Immune Endotypes in Sepsis (SPIES Study) Role:Collaborator $159,799.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Baker, Jennifer E; Niziolek, Grace M; Elson, Nora C; Pugh, Amanda M; Nomellini, Vanessa; Makley, Amy T; Pritts, Timothy A; Goodman, Michael D (2019. ) Optimizing Lower Extremity Duplex Ultrasound Screening After Traumatic Injury.The Journal of surgical research, , 243 ,143-150 More Information

Winer, Leah K; Beckmann, Nadine; Veile, Rosalie A; Goodman, Michael D; Caldwell, Charles C; Nomellini, Vanessa (2019. ) Consumptive coagulopathy is associated with organ dysfunction during PICS.American journal of physiology. Lung cellular and molecular physiology, , 316 (5 ) ,L946-L952 More Information

Martin, Grace E; Pugh, Amanda; Williams, Susan G; Hanseman, Dennis; Nomellini, Vanessa; Makley, Amy T; Pritts, Timothy A; Goodman, Michael D (2019. ) Lower Extremity Duplex Ultrasound Screening Protocol for Moderate- and High-Risk Trauma Patients.The Journal of surgical research, , 235 ,280-287 More Information

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Kim, Young; Goetzman, Holly S; Veile, Rosalie E; Gulbins, Erich; Goodman, Michael D; Nomellini, Vanessa; Caldwell, Charles C (2019. ) Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.Shock (Augusta, Ga.), , 51 (3 ) ,356-363 More Information

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Pugh, Amanda M; Pritts, Timothy A; Nomellini, Vanessa; Gulbins, Erich; Caldwell, Charles C (2019. ) Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 52 (3 ) ,565-579 More Information

Baker, Jennifer E; Martin, Grace E; Katsaros, Gianna; Lewis, Hannah V; Wakefield, Connor J; Josephs, Sean A; Nomellini, Vanessa; Makley, Amy T; Goodman, Michael D (2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma surgery & acute care open, , 3 (1 ) ,e000240 More Information

Jung, Andrew D; Baker, Jennifer; Droege, Christopher A; Nomellini, Vanessa; Johannigman, Jay; Holcomb, John B; Goodman, Michael D; Pritts, Timothy A (2018. ) Sooner is better: use of a real-time automated bedside dashboard improves sepsis care.The Journal of surgical research, , 231 ,373-379 More Information

Nomellini, Vanessa; Kaplan, Lewis J; Sims, Carrie A; Caldwell, Charles C (2018. ) Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, Septic, and Malnourished?.Shock (Augusta, Ga.), , 49 (1 ) ,4-14 More Information

Rice, Teresa C; Pugh, Amanda M; Seitz, Aaron P; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C (2017. ) Sphingosine rescues aged mice from pulmonary pseudomonas infection.The Journal of surgical research, , 219 ,354-359 More Information

Pugh, Amanda M; Auteri, Nicholas J; Goetzman, Holly S; Caldwell, Charles C; Nomellini, Vanessa (2017. ) A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome.International journal of molecular sciences, , 18 (8 ) , More Information

Adams M.;Nomellini V.;Bennett S. (09-01-2018. ) Anesthetic Concerns in the Pregnant Trauma Patient.Current Trauma Reports, , 4 (3 ) ,218-224 More Information

Baker J.E.;Martin G.E.;Katsaros G.;Lewis H.V.;Wakefield C.J.;Josephs S.A.;Nomellini V.;Makley A.T.;Goodman M.D. (01-01-2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma Surgery and Acute Care Open, , 3 (1 ) , More Information

Carlson A.R.;Nomellini V.;Neuman H.B. (01-01-2014. ) Importance of high clinical suspicion in diagnosing a marjolin's ulcer with an unusual presentation .American Surgeon, , 80 (2 ) ,E61-E62

Nomellini V.;Kent K. (11-01-2013. ) The department of surgery at the university of Wisconsin .American Surgeon, , 79 (11 ) ,1123-1130

Nomellini V.;Brubaker A.;Mahbub S.;Palmer J.;Gomez C.;Kovacs E. (01-01-2012. ) Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary in .Aging and Disease, , 3 (3 ) ,234-247

Kovacs E.;Gomez C.;Karavitis J.;Palmer J.;Faunce D.;Ramirez L.;Nomellini V. (08-13-2010. ) Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.Mediators of Inflammation, , 2010 , More Information

Gomez C.;Nomellini V.;Baila H.;Oshima K.;Kovacs E. (02-01-2009. ) Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of sy.Shock, , 31 (2 ) ,178-184 More Information

Gomez C.R.;Nomellini V.;Kovacs E.J. (01-01-2009. ) Sex hormones and immunosenescence.Handbook on Immunosenescence: Basic Understanding and Clinical Applications, , 799-831 More Information

Nomellini V.;Gomez C.;Gamelli R.;Kovacs E. (01-01-2009. ) Aging and animal models of systemic insult: Trauma, burn, and sepsis.Shock, , 31 (1 ) ,11-20 More Information

Nomellini V.;Gomez C.;Kovacs E. (08-20-2008. ) Aging and impairment of innate immunity.Contributions to Microbiology, , 15 ,188-205 More Information

Gomez C.;Nomellini V.;Faunce D.;Kovacs E. (08-01-2008. ) Innate immunity and aging.Experimental Gerontology, , 43 (8 ) ,718-728 More Information

Nomellini V.;Faunce D.;Gomez C.;Kovacs E. (06-01-2008. ) An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibit.Journal of Leukocyte Biology, , 83 (6 ) ,1493-1501 More Information

Gomez C.;Nomellini V.;Boehmer E.;Kovacs E. (02-01-2007. ) Signal transduction of the aging innate immune system.Current Immunology Reviews, , 3 (1 ) ,23-30 More Information

Gomez C.;Hirano S.;Cutro B.;Birjandi S.;Baila H.;Nomellini V.;Kovacs E. (01-01-2007. ) Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.Critical Care Medicine, , 35 (1 ) ,246-251 More Information

Adams M.; Bennett S.; Nomellini V. (09-01-2018. ) Anesthetic Concerns in the Pregnant Trauma Patient.Current Trauma Reports, , 4 (3 ) ,218-224 More Information

Baker J.E.; Goodman M.D.; Josephs S.A.; Katsaros G.; Lewis H.V.; Makley A.T.; Martin G.E.; Nomellini V.; Wakefield C.J. (01-01-2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma Surgery and Acute Care Open, , 3 (1 ) , More Information

Carlson A.; Neuman H.; Nomellini V. (01-01-2014. ) Importance of high clinical suspicion in diagnosing a marjolin's ulcer with an unusual presentation .American Surgeon, , 80 (2 ) ,E61-E62

Kent K.; Nomellini V. (11-01-2013. ) The department of surgery at the university of Wisconsin .American Surgeon, , 79 (11 ) ,1123-1130

Brubaker A.; Gomez C.; Kovacs E.; Mahbub S.; Nomellini V.; Palmer J. (01-01-2012. ) Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary in .Aging and Disease, , 3 (3 ) ,234-247

Faunce D.; Gomez C.; Karavitis J.; Kovacs E.; Nomellini V.; Palmer J.; Ramirez L. (08-13-2010. ) Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.Mediators of Inflammation, , 2010 , More Information

Baila H.; Gomez C.; Kovacs E.; Nomellini V.; Oshima K. (02-01-2009. ) Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of sy.Shock, , 31 (2 ) ,178-184 More Information

Gomez C.; Kovacs E.; Nomellini V. (01-01-2009. ) Sex hormones and immunosenescence.Handbook on Immunosenescence: Basic Understanding and Clinical Applications, , 799-831 More Information

Gamelli R.; Gomez C.; Kovacs E.; Nomellini V. (01-01-2009. ) Aging and animal models of systemic insult: Trauma, burn, and sepsis.Shock, , 31 (1 ) ,11-20 More Information

Gomez C.; Kovacs E.; Nomellini V. (08-20-2008. ) Aging and impairment of innate immunity.Contributions to Microbiology, , 15 ,188-205 More Information

Faunce D.; Gomez C.; Kovacs E.; Nomellini V. (08-01-2008. ) Innate immunity and aging.Experimental Gerontology, , 43 (8 ) ,718-728 More Information

Faunce D.; Gomez C.; Kovacs E.; Nomellini V. (06-01-2008. ) An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibit.Journal of Leukocyte Biology, , 83 (6 ) ,1493-1501 More Information

Boehmer E.; Gomez C.; Kovacs E.; Nomellini V. (02-01-2007. ) Signal transduction of the aging innate immune system.Current Immunology Reviews, , 3 (1 ) ,23-30 More Information

Baila H.; Birjandi S.; Cutro B.; Gomez C.; Hirano S.; Kovacs E.; Nomellini V. (01-01-2007. ) Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.Critical Care Medicine, , 35 (1 ) ,246-251 More Information

Tobin, Joshua M; Gavitt, Brian J; Nomellini, Vanessa; Dobson, Geoffrey P; Letson, Hayley L; Shackelford, Stacy A (2020. ) Immunotherapeutic options for inflammation in trauma.The journal of trauma and acute care surgery, , 89 (2S Suppl 2 ) ,S77-S82 More Information

Tobin, Joshua M; Gavitt, Brian J; Nomellini, Vanessa; Dobson, Geoffrey P; Letson, Hayley L; Shackelford, Stacy A (2020. ) Immuno-therapeutic Options for Inflammation in Trauma.The journal of trauma and acute care surgery, , More Information

Sengupta, Satarupa; Caldwell, Charles C; Nomellini, Vanessa (2020. ) Distinct Neutrophil Populations in the Spleen During PICS.Frontiers in immunology, , 11 ,804 More Information

Beckmann, Nadine; Huber, Franziska; Hanschen, Marc; St Pierre Schneider, Barbara; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling.Frontiers in immunology, , 11 ,876 More Information

Beckmann, Nadine; Salyer, Christen E; Crisologo, Peter A; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Staging and Personalized Intervention for Infection and Sepsis.Surgical infections, , More Information