
Vanessa Nomellini
Associate Professor of Clinical
Surgical Research Unit
COM Surgery Trauma & Critical Care - 0558
Education
Bachelor's Degree, DePaul University 2003
Medical Degree, Loyola University 2010
Doctoral Degree, Loyola University 2010 (Biochemistry)
General Surgery Residency, University of Wisconsin 2015
Critical Care Fellowship, University of Pennsylvania 2016
Clinical Focus
Critical Care Surgery
General Surgery
Specialities
Surgery-Critical Care
Certifications
American Board of Surgery (Surgery Critical Care)
09/12/2016
American Board of Surgery
11/16/2015Research Support
Grant: #AAST 2017 Investigators:Nomellini, Vanessa 07-01-2017 -06-30-2018 American Association for the Surgery of Trauma The Role of Sphingosine in the Susceptibility of Pneumonia in the Elderly Role:PI $50,000.00 Awarded Level:Private Non-Profit
Grant: #K08GM131284 Investigators:Nomellini, Vanessa 09-20-2018 -08-31-2023 National Institute of General Medical Sciences Mechanisms of Altered Neutrophil Trafficking in the Persistent Inflammation, Immunosuppression, Catabolism Syndrome Role:PI $199,566.00 Active Level:Federal
Grant: #85219-CIN-17 Investigators:Caldwell, Charles; Gulbins, Erich; Nomellini, Vanessa 01-01-2020 -12-31-2022 Shriners Hospitals for Children - Cincinnati Ceramide regulatory role upon neutrophil chemotaxis after burn injury Role:Collaborator $249,873.00 Active Level:Private Non-Profit
Grant: #R35GM138020 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-01-2020 -06-30-2025 National Institute of General Medical Sciences Utilizing Immune Phenotypes to Prevent Chronic Critical Illness Role:PI $401,250.00 Awarded Level:Federal
Grant: #SUB00002421 / R01GM139046 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-05-2020 -06-30-2025 National Institute of General Medical Sciences Stratifying Patient Immune Endotypes in Sepsis (SPIES Study) Role:Collaborator $159,799.00 Awarded Level:Federal
Publications
Peer Reviewed Publications
Baker, Jennifer E; Niziolek, Grace M; Elson, Nora C; Pugh, Amanda M; Nomellini, Vanessa; Makley, Amy T; Pritts, Timothy A; Goodman, Michael D (2019. ) Optimizing Lower Extremity Duplex Ultrasound Screening After Traumatic Injury.The Journal of surgical research, , 243 ,143-150
Winer, Leah K; Beckmann, Nadine; Veile, Rosalie A; Goodman, Michael D; Caldwell, Charles C; Nomellini, Vanessa (2019. ) Consumptive coagulopathy is associated with organ dysfunction during PICS.American journal of physiology. Lung cellular and molecular physiology, , 316 (5 ) ,L946-L952
Martin, Grace E; Pugh, Amanda; Williams, Susan G; Hanseman, Dennis; Nomellini, Vanessa; Makley, Amy T; Pritts, Timothy A; Goodman, Michael D (2019. ) Lower Extremity Duplex Ultrasound Screening Protocol for Moderate- and High-Risk Trauma Patients.The Journal of surgical research, , 235 ,280-287
Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Kim, Young; Goetzman, Holly S; Veile, Rosalie E; Gulbins, Erich; Goodman, Michael D; Nomellini, Vanessa; Caldwell, Charles C (2019. ) Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.Shock (Augusta, Ga.), , 51 (3 ) ,356-363
Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Pugh, Amanda M; Pritts, Timothy A; Nomellini, Vanessa; Gulbins, Erich; Caldwell, Charles C (2019. ) Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 52 (3 ) ,565-579
Baker, Jennifer E; Martin, Grace E; Katsaros, Gianna; Lewis, Hannah V; Wakefield, Connor J; Josephs, Sean A; Nomellini, Vanessa; Makley, Amy T; Goodman, Michael D (2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma surgery & acute care open, , 3 (1 ) ,e000240
Jung, Andrew D; Baker, Jennifer; Droege, Christopher A; Nomellini, Vanessa; Johannigman, Jay; Holcomb, John B; Goodman, Michael D; Pritts, Timothy A (2018. ) Sooner is better: use of a real-time automated bedside dashboard improves sepsis care.The Journal of surgical research, , 231 ,373-379
Nomellini, Vanessa; Kaplan, Lewis J; Sims, Carrie A; Caldwell, Charles C (2018. ) Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, Septic, and Malnourished?.Shock (Augusta, Ga.), , 49 (1 ) ,4-14
Rice, Teresa C; Pugh, Amanda M; Seitz, Aaron P; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C (2017. ) Sphingosine rescues aged mice from pulmonary pseudomonas infection.The Journal of surgical research, , 219 ,354-359
Pugh, Amanda M; Auteri, Nicholas J; Goetzman, Holly S; Caldwell, Charles C; Nomellini, Vanessa (2017. ) A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome.International journal of molecular sciences, , 18 (8 ) ,
Adams M.;Nomellini V.;Bennett S. (09-01-2018. ) Anesthetic Concerns in the Pregnant Trauma Patient.Current Trauma Reports, , 4 (3 ) ,218-224
Baker J.E.;Martin G.E.;Katsaros G.;Lewis H.V.;Wakefield C.J.;Josephs S.A.;Nomellini V.;Makley A.T.;Goodman M.D. (01-01-2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma Surgery and Acute Care Open, , 3 (1 ) ,
Carlson A.R.;Nomellini V.;Neuman H.B. (01-01-2014. ) Importance of high clinical suspicion in diagnosing a marjolin's ulcer with an unusual presentation .American Surgeon, , 80 (2 ) ,E61-E62
Nomellini V.;Kent K. (11-01-2013. ) The department of surgery at the university of Wisconsin .American Surgeon, , 79 (11 ) ,1123-1130
Nomellini V.;Brubaker A.;Mahbub S.;Palmer J.;Gomez C.;Kovacs E. (01-01-2012. ) Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary in .Aging and Disease, , 3 (3 ) ,234-247
Kovacs E.;Gomez C.;Karavitis J.;Palmer J.;Faunce D.;Ramirez L.;Nomellini V. (08-13-2010. ) Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.Mediators of Inflammation, , 2010 ,
Gomez C.;Nomellini V.;Baila H.;Oshima K.;Kovacs E. (02-01-2009. ) Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of sy.Shock, , 31 (2 ) ,178-184
Gomez C.R.;Nomellini V.;Kovacs E.J. (01-01-2009. ) Sex hormones and immunosenescence.Handbook on Immunosenescence: Basic Understanding and Clinical Applications, , 799-831
Nomellini V.;Gomez C.;Gamelli R.;Kovacs E. (01-01-2009. ) Aging and animal models of systemic insult: Trauma, burn, and sepsis.Shock, , 31 (1 ) ,11-20
Nomellini V.;Gomez C.;Kovacs E. (08-20-2008. ) Aging and impairment of innate immunity.Contributions to Microbiology, , 15 ,188-205
Gomez C.;Nomellini V.;Faunce D.;Kovacs E. (08-01-2008. ) Innate immunity and aging.Experimental Gerontology, , 43 (8 ) ,718-728
Nomellini V.;Faunce D.;Gomez C.;Kovacs E. (06-01-2008. ) An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibit.Journal of Leukocyte Biology, , 83 (6 ) ,1493-1501
Gomez C.;Nomellini V.;Boehmer E.;Kovacs E. (02-01-2007. ) Signal transduction of the aging innate immune system.Current Immunology Reviews, , 3 (1 ) ,23-30
Gomez C.;Hirano S.;Cutro B.;Birjandi S.;Baila H.;Nomellini V.;Kovacs E. (01-01-2007. ) Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.Critical Care Medicine, , 35 (1 ) ,246-251
Adams M.; Bennett S.; Nomellini V. (09-01-2018. ) Anesthetic Concerns in the Pregnant Trauma Patient.Current Trauma Reports, , 4 (3 ) ,218-224
Baker J.E.; Goodman M.D.; Josephs S.A.; Katsaros G.; Lewis H.V.; Makley A.T.; Martin G.E.; Nomellini V.; Wakefield C.J. (01-01-2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma Surgery and Acute Care Open, , 3 (1 ) ,
Carlson A.; Neuman H.; Nomellini V. (01-01-2014. ) Importance of high clinical suspicion in diagnosing a marjolin's ulcer with an unusual presentation .American Surgeon, , 80 (2 ) ,E61-E62
Kent K.; Nomellini V. (11-01-2013. ) The department of surgery at the university of Wisconsin .American Surgeon, , 79 (11 ) ,1123-1130
Brubaker A.; Gomez C.; Kovacs E.; Mahbub S.; Nomellini V.; Palmer J. (01-01-2012. ) Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary in .Aging and Disease, , 3 (3 ) ,234-247
Faunce D.; Gomez C.; Karavitis J.; Kovacs E.; Nomellini V.; Palmer J.; Ramirez L. (08-13-2010. ) Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.Mediators of Inflammation, , 2010 ,
Baila H.; Gomez C.; Kovacs E.; Nomellini V.; Oshima K. (02-01-2009. ) Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of sy.Shock, , 31 (2 ) ,178-184
Gomez C.; Kovacs E.; Nomellini V. (01-01-2009. ) Sex hormones and immunosenescence.Handbook on Immunosenescence: Basic Understanding and Clinical Applications, , 799-831
Gamelli R.; Gomez C.; Kovacs E.; Nomellini V. (01-01-2009. ) Aging and animal models of systemic insult: Trauma, burn, and sepsis.Shock, , 31 (1 ) ,11-20
Gomez C.; Kovacs E.; Nomellini V. (08-20-2008. ) Aging and impairment of innate immunity.Contributions to Microbiology, , 15 ,188-205
Faunce D.; Gomez C.; Kovacs E.; Nomellini V. (08-01-2008. ) Innate immunity and aging.Experimental Gerontology, , 43 (8 ) ,718-728
Faunce D.; Gomez C.; Kovacs E.; Nomellini V. (06-01-2008. ) An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibit.Journal of Leukocyte Biology, , 83 (6 ) ,1493-1501
Boehmer E.; Gomez C.; Kovacs E.; Nomellini V. (02-01-2007. ) Signal transduction of the aging innate immune system.Current Immunology Reviews, , 3 (1 ) ,23-30
Baila H.; Birjandi S.; Cutro B.; Gomez C.; Hirano S.; Kovacs E.; Nomellini V. (01-01-2007. ) Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.Critical Care Medicine, , 35 (1 ) ,246-251
Tobin, Joshua M; Gavitt, Brian J; Nomellini, Vanessa; Dobson, Geoffrey P; Letson, Hayley L; Shackelford, Stacy A (2020. ) Immunotherapeutic options for inflammation in trauma.The journal of trauma and acute care surgery, , 89 (2S Suppl 2 ) ,S77-S82
Tobin, Joshua M; Gavitt, Brian J; Nomellini, Vanessa; Dobson, Geoffrey P; Letson, Hayley L; Shackelford, Stacy A (2020. ) Immuno-therapeutic Options for Inflammation in Trauma.The journal of trauma and acute care surgery, ,
Sengupta, Satarupa; Caldwell, Charles C; Nomellini, Vanessa (2020. ) Distinct Neutrophil Populations in the Spleen During PICS.Frontiers in immunology, , 11 ,804
Beckmann, Nadine; Huber, Franziska; Hanschen, Marc; St Pierre Schneider, Barbara; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling.Frontiers in immunology, , 11 ,876
Beckmann, Nadine; Salyer, Christen E; Crisologo, Peter A; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Staging and Personalized Intervention for Infection and Sepsis.Surgical infections, ,