Vanessa Nomellini

Vanessa Nomellini

Associate Professor of Clinical

Surgical Research Unit

COM Surgery Trauma & Critical Care - 0558

Education

Bachelor's Degree, DePaul University 2003

Medical Degree, Loyola University 2010

Doctoral Degree, Loyola University 2010 (Biochemistry)

General Surgery Residency, University of Wisconsin 2015

Critical Care Fellowship, University of Pennsylvania 2016

Clinical Focus

Critical Care Surgery

General Surgery

Specialities

Surgery-Critical Care

Certifications

American Board of Surgery (Surgery Critical Care)

09/12/2016

American Board of Surgery

11/16/2015

Research Support

Grant: #AAST 2017 Investigators:Nomellini, Vanessa 07-01-2017 -06-30-2018 American Association for the Surgery of Trauma The Role of Sphingosine in the Susceptibility of Pneumonia in the Elderly Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #K08GM131284 Investigators:Nomellini, Vanessa 09-20-2018 -08-31-2023 National Institute of General Medical Sciences Mechanisms of Altered Neutrophil Trafficking in the Persistent Inflammation, Immunosuppression, Catabolism Syndrome Role:PI $199,566.00 Active Level:Federal

Grant: #85219-CIN-17 Investigators:Caldwell, Charles; Gulbins, Erich; Nomellini, Vanessa 01-01-2020 -12-31-2022 Shriners Hospitals for Children - Cincinnati Ceramide regulatory role upon neutrophil chemotaxis after burn injury Role:Collaborator $249,873.00 Active Level:Private Non-Profit

Grant: #R35GM138020 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-01-2020 -06-30-2025 National Institute of General Medical Sciences Utilizing Immune Phenotypes to Prevent Chronic Critical Illness Role:PI $401,250.00 Awarded Level:Federal

Grant: #SUB00002421 / R01GM139046 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-05-2020 -06-30-2025 National Institute of General Medical Sciences Stratifying Patient Immune Endotypes in Sepsis (SPIES Study) Role:Collaborator $159,799.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Baker, Jennifer E; Niziolek, Grace M; Elson, Nora C; Pugh, Amanda M; Nomellini, Vanessa; Makley, Amy T; Pritts, Timothy A; Goodman, Michael D (2019. ) Optimizing Lower Extremity Duplex Ultrasound Screening After Traumatic Injury.The Journal of surgical research, , 243 ,143-150

Winer, Leah K; Beckmann, Nadine; Veile, Rosalie A; Goodman, Michael D; Caldwell, Charles C; Nomellini, Vanessa (2019. ) Consumptive coagulopathy is associated with organ dysfunction during PICS.American journal of physiology. Lung cellular and molecular physiology, , 316 (5 ) ,L946-L952

Martin, Grace E; Pugh, Amanda; Williams, Susan G; Hanseman, Dennis; Nomellini, Vanessa; Makley, Amy T; Pritts, Timothy A; Goodman, Michael D (2019. ) Lower Extremity Duplex Ultrasound Screening Protocol for Moderate- and High-Risk Trauma Patients.The Journal of surgical research, , 235 ,280-287

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Kim, Young; Goetzman, Holly S; Veile, Rosalie E; Gulbins, Erich; Goodman, Michael D; Nomellini, Vanessa; Caldwell, Charles C (2019. ) Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.Shock (Augusta, Ga.), , 51 (3 ) ,356-363

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Pugh, Amanda M; Pritts, Timothy A; Nomellini, Vanessa; Gulbins, Erich; Caldwell, Charles C (2019. ) Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 52 (3 ) ,565-579

Baker, Jennifer E; Martin, Grace E; Katsaros, Gianna; Lewis, Hannah V; Wakefield, Connor J; Josephs, Sean A; Nomellini, Vanessa; Makley, Amy T; Goodman, Michael D (2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma surgery & acute care open, , 3 (1 ) ,e000240

Jung, Andrew D; Baker, Jennifer; Droege, Christopher A; Nomellini, Vanessa; Johannigman, Jay; Holcomb, John B; Goodman, Michael D; Pritts, Timothy A (2018. ) Sooner is better: use of a real-time automated bedside dashboard improves sepsis care.The Journal of surgical research, , 231 ,373-379

Nomellini, Vanessa; Kaplan, Lewis J; Sims, Carrie A; Caldwell, Charles C (2018. ) Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, Septic, and Malnourished?.Shock (Augusta, Ga.), , 49 (1 ) ,4-14

Rice, Teresa C; Pugh, Amanda M; Seitz, Aaron P; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C (2017. ) Sphingosine rescues aged mice from pulmonary pseudomonas infection.The Journal of surgical research, , 219 ,354-359

Pugh, Amanda M; Auteri, Nicholas J; Goetzman, Holly S; Caldwell, Charles C; Nomellini, Vanessa (2017. ) A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome.International journal of molecular sciences, , 18 (8 ) ,

Adams M.;Nomellini V.;Bennett S. (09-01-2018. ) Anesthetic Concerns in the Pregnant Trauma Patient.Current Trauma Reports, , 4 (3 ) ,218-224

Baker J.E.;Martin G.E.;Katsaros G.;Lewis H.V.;Wakefield C.J.;Josephs S.A.;Nomellini V.;Makley A.T.;Goodman M.D. (01-01-2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma Surgery and Acute Care Open, , 3 (1 ) ,

Carlson A.R.;Nomellini V.;Neuman H.B. (01-01-2014. ) Importance of high clinical suspicion in diagnosing a marjolin's ulcer with an unusual presentation .American Surgeon, , 80 (2 ) ,E61-E62

Nomellini V.;Kent K. (11-01-2013. ) The department of surgery at the university of Wisconsin .American Surgeon, , 79 (11 ) ,1123-1130

Nomellini V.;Brubaker A.;Mahbub S.;Palmer J.;Gomez C.;Kovacs E. (01-01-2012. ) Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary in .Aging and Disease, , 3 (3 ) ,234-247

Kovacs E.;Gomez C.;Karavitis J.;Palmer J.;Faunce D.;Ramirez L.;Nomellini V. (08-13-2010. ) Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.Mediators of Inflammation, , 2010 ,

Gomez C.;Nomellini V.;Baila H.;Oshima K.;Kovacs E. (02-01-2009. ) Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of sy.Shock, , 31 (2 ) ,178-184

Gomez C.R.;Nomellini V.;Kovacs E.J. (01-01-2009. ) Sex hormones and immunosenescence.Handbook on Immunosenescence: Basic Understanding and Clinical Applications, , 799-831

Nomellini V.;Gomez C.;Gamelli R.;Kovacs E. (01-01-2009. ) Aging and animal models of systemic insult: Trauma, burn, and sepsis.Shock, , 31 (1 ) ,11-20

Nomellini V.;Gomez C.;Kovacs E. (08-20-2008. ) Aging and impairment of innate immunity.Contributions to Microbiology, , 15 ,188-205

Gomez C.;Nomellini V.;Faunce D.;Kovacs E. (08-01-2008. ) Innate immunity and aging.Experimental Gerontology, , 43 (8 ) ,718-728

Nomellini V.;Faunce D.;Gomez C.;Kovacs E. (06-01-2008. ) An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibit.Journal of Leukocyte Biology, , 83 (6 ) ,1493-1501

Gomez C.;Nomellini V.;Boehmer E.;Kovacs E. (02-01-2007. ) Signal transduction of the aging innate immune system.Current Immunology Reviews, , 3 (1 ) ,23-30

Gomez C.;Hirano S.;Cutro B.;Birjandi S.;Baila H.;Nomellini V.;Kovacs E. (01-01-2007. ) Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.Critical Care Medicine, , 35 (1 ) ,246-251

Adams M.; Bennett S.; Nomellini V. (09-01-2018. ) Anesthetic Concerns in the Pregnant Trauma Patient.Current Trauma Reports, , 4 (3 ) ,218-224

Baker J.E.; Goodman M.D.; Josephs S.A.; Katsaros G.; Lewis H.V.; Makley A.T.; Martin G.E.; Nomellini V.; Wakefield C.J. (01-01-2018. ) Variability of fluid administration during exploratory laparotomy for abdominal trauma.Trauma Surgery and Acute Care Open, , 3 (1 ) ,

Carlson A.; Neuman H.; Nomellini V. (01-01-2014. ) Importance of high clinical suspicion in diagnosing a marjolin's ulcer with an unusual presentation .American Surgeon, , 80 (2 ) ,E61-E62

Kent K.; Nomellini V. (11-01-2013. ) The department of surgery at the university of Wisconsin .American Surgeon, , 79 (11 ) ,1123-1130

Brubaker A.; Gomez C.; Kovacs E.; Mahbub S.; Nomellini V.; Palmer J. (01-01-2012. ) Dysregulation of neutrophil CXCR2 and pulmonary endothelial ICAM-1 promotes age-related pulmonary in .Aging and Disease, , 3 (3 ) ,234-247

Faunce D.; Gomez C.; Karavitis J.; Kovacs E.; Nomellini V.; Palmer J.; Ramirez L. (08-13-2010. ) Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.Mediators of Inflammation, , 2010 ,

Baila H.; Gomez C.; Kovacs E.; Nomellini V.; Oshima K. (02-01-2009. ) Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of sy.Shock, , 31 (2 ) ,178-184

Gomez C.; Kovacs E.; Nomellini V. (01-01-2009. ) Sex hormones and immunosenescence.Handbook on Immunosenescence: Basic Understanding and Clinical Applications, , 799-831

Gamelli R.; Gomez C.; Kovacs E.; Nomellini V. (01-01-2009. ) Aging and animal models of systemic insult: Trauma, burn, and sepsis.Shock, , 31 (1 ) ,11-20

Gomez C.; Kovacs E.; Nomellini V. (08-20-2008. ) Aging and impairment of innate immunity.Contributions to Microbiology, , 15 ,188-205

Faunce D.; Gomez C.; Kovacs E.; Nomellini V. (08-01-2008. ) Innate immunity and aging.Experimental Gerontology, , 43 (8 ) ,718-728

Faunce D.; Gomez C.; Kovacs E.; Nomellini V. (06-01-2008. ) An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibit.Journal of Leukocyte Biology, , 83 (6 ) ,1493-1501

Boehmer E.; Gomez C.; Kovacs E.; Nomellini V. (02-01-2007. ) Signal transduction of the aging innate immune system.Current Immunology Reviews, , 3 (1 ) ,23-30

Baila H.; Birjandi S.; Cutro B.; Gomez C.; Hirano S.; Kovacs E.; Nomellini V. (01-01-2007. ) Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure.Critical Care Medicine, , 35 (1 ) ,246-251

Tobin, Joshua M; Gavitt, Brian J; Nomellini, Vanessa; Dobson, Geoffrey P; Letson, Hayley L; Shackelford, Stacy A (2020. ) Immunotherapeutic options for inflammation in trauma.The journal of trauma and acute care surgery, , 89 (2S Suppl 2 ) ,S77-S82

Tobin, Joshua M; Gavitt, Brian J; Nomellini, Vanessa; Dobson, Geoffrey P; Letson, Hayley L; Shackelford, Stacy A (2020. ) Immuno-therapeutic Options for Inflammation in Trauma.The journal of trauma and acute care surgery, ,

Sengupta, Satarupa; Caldwell, Charles C; Nomellini, Vanessa (2020. ) Distinct Neutrophil Populations in the Spleen During PICS.Frontiers in immunology, , 11 ,804

Beckmann, Nadine; Huber, Franziska; Hanschen, Marc; St Pierre Schneider, Barbara; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling.Frontiers in immunology, , 11 ,876

Beckmann, Nadine; Salyer, Christen E; Crisologo, Peter A; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Staging and Personalized Intervention for Infection and Sepsis.Surgical infections, ,