Richard J. Paul , PhD

Research: Control of smooth muscle contractility and its coordination with metabolism.
Teaching:  Muscle Mechanics, Metabolism & Energetics, &  Thermodynamics in Biological Systems.
Service:  Director, Systems Biology and Physiology PhD Program.  University and COM Graduate Committees, MCP ARPT, AAUP Treasurer.

PhD: Harvard University Cambridge, MA, 1973 (Biophysics)

My research interests focus on the mechanisms underlying the control of smooth muscle contractility and its coordination with metabolism. We use gene-altered mice, opening new avenues for studying basic smooth muscle mechanisms and diseases from coronary artery vasospasm to hypertension. 

Visit the Paul Laboratory Homepage.

Grant: #1 RO1 Investigators:Pyne-Getheman, P.I 03-01-2005 -01-31-2011 NIH Cerebral Vasospasm after Subarachnoid hemorrhage 1,250,000 Active Type:Grant

Grant: #1RO1 NS052700 Investigators:A.. MacLennal P.I. 04-01-2006 -03-31-2011 NIH CNTF Receptors: Neuromuscular Protection/Repair In Vivo 1,866,081 Active Type:Grant

Grant: #AHA 6055300B 07-06-2006 -06-30-2008 American Heart Association Coronary Oxygen–Sensing and Hypoxic Vasorelaxation Role:P.I. 120,000 Completed Type:Grant

Investigators:McGraw, P.I., Paul, R.J. 04-11-2009 -03-2013 NIH/NHLBI Type VA Merit Award Role of Gai2 in Hypertension $120,000 Active Type:Grant

Grant: #RO1 Investigators:de Lanerolle, P.I., Paul, R.J. subcontract 5% 04-01-2009 -03-31-2013 NIH/NHLBI Signal Transduction in Blood Vessels Scored Role:Subcontract $169,240 Pending Type:Grant

Grant: #NSF IGERT Pre Proposal Investigators:Montrose, M.H., and Paul, R.J; Multiple PIs 07-01-2009 -06-30-2014 NSF Systems Biology of Complex Living Systems. Role:multiple PI Denied Type:Grant

Grant: #T32 Investigators: Montrose, M.H. and Paul, R.J; Multiple PIs 07-01-2009 -06-30-2014 NIH /Howard Hughes Foundation Training Grant Systems Biology of Vertebrate Organisms Role:Multiple PI 167,088 Denied Type:Grant

Investigators:Mishra, A. and Paul, R.J., subcontract 01-01-2010 -12-31-2011 Challenge grant Esophageal Leiomyomatosis, Eosinophilic Esophagitis (Ee) and Gastroesophageal Reflux Disease. Role:Subcontract Denied Type:Grant

Grant: #AHA 6055300B Investigators:Paul, Richard 07-01-2006 -06-30-2008 American Heart Association - Ohio Valley Coronary Artery Oxygen-Sensing and Hypoxic Vasorelaxation Role:PI $121,000.00 Closed Level:Private Non-Profit

Grant: #5-R01-HL-66044-04-A0-S0-E0 Investigators:Paul, Richard 01-01-2001 -12-31-2006 National Heart, Lung and Blood Institute Na-Pump Isoform-Specific Regulation of Vascular Function Role:PI $1,547,060.00 Closed Level:Federal

Grant: #5-R01-HL-54829-04-A0-S0-E0 Investigators:Paul, Richard 08-01-1997 -07-31-2002 National Heart, Lung and Blood Institute Phospholamban Modulation of Smooth Muscle Contractility Role:PI $1,134,302.00 Closed Level:Federal

Grant: #5-R01-HL-52460-05-A0-S0-E0 Investigators:Paul, Richard 09-30-1993 -08-31-1999 National Heart, Lung and Blood Institute Studies on Animals Subjected to Estrogen Deprivation and Estrogen Replacement Therapy Role:PI $191,206.00 Closed Level:Federal

Grant: #5-T32-HL-07571-20-A0-S0-E0 Investigators:Paul, Richard 07-01-1999 -06-30-2004 National Heart, Lung and Blood Institute Training in Smooth and Cardiac Muscle Biology Role:PI $1,621,856.72 Closed Level:Federal

Investigators:Paul, Richard 04-01-2000 -03-31-2006 National Heart, Lung and Blood Institute Myosin Isoform Function in Vascular Smooth Muscle Role:PI $458,978.00 Closed Level:Federal

Grant: #R01 HL092121 Investigators:Lorenz, John; McGraw, Dennis; Paul, Richard 09-01-2009 -06-30-2014 National Heart, Lung and Blood Institute The Role of Ga2 Signaling in Hypertension Role:Collaborator $1,566,075.00 Active Level:Federal

Published Abstracts

Gu, M., Ishida, Y., Wardle, R.L., Bowman, P.D. and Paul, R.J. Hypoxic vasorelaxation in porcine coronary artery is not mediated by reactive oxygen species .[Abstract]

Lilly, B., Clark, K.A., Yoshigi, M., Pronovost, S., Wu, M-L., Paul, R.J., Yet, S-F., and Beckerle, M.C. The smooth muscle marker cysteine-rich protein 1 is not essential for smooth muscle development, but participates in the vascular injury response. .[Abstract]

Nobe, K., Yoshida, H.O., Nobe, H., Kolodney, M., Paul, R., Honda, K. Rho A and the Rho Kinase Pathway Regulate Fibroblast Contraction in Wound Healing:Enhanced Contraction in Dominant Active Rho A Fibroblast Cells Manuscript Number: C-00485-2006 .[Abstract]

Pritchard, T.J., Bowman, P.S., Jefferson, A., Lynch, R.M. and Paul, R.J. Na+-K+ ATPase and Ca2+ clearance proteins in smooth muscle: A functional unit? .[Abstract]

Pritchard, T.J., Paul, R.J. and Lynch, R. M. Increased Na+-K+ ATPase Decreases Intracellular Ca2+ in Smooth Muscle: Evidence from Transgenic Mice .[Abstract]

Peer Reviewed Publications

Lilly, B.; Clark, K. A.; Yoshigi, M.; Pronovost, S.; Wu, M. L.; Periasamy, M.; Chi, M.; Paul, R. J.; Yet, S. F.; Beckerle, M. C. (2010. ) Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse .Arterioscler Thromb Vasc Biol, , 30 (4 ) ,694-701

Pritchard, Tracy J; Bowman, Peggy Sue; Jefferson, Andrew; Tosun, Metiner; Lynch, Ronald M; Paul, Richard J (2010. ) Na+-K+ ATPase and Ca2+ Clearance Proteins in Smooth Muscle: A Functional Unit.American journal of physiology. Heart and circulatory physiology, , More Information

Pritchard, T. J.; Bowman, P. S.; Jefferson, A.; Tosun, M.; Lynch, R. M.; Paul, R. J. (2010. ) Na(+)-K(+)-ATPase and Ca(2+) clearance proteins in smooth muscle: a functional unit .Am J Physiol Heart Circ Physiol, , 299 (2 ) ,H548-56

Gu, M., Ishida, Y., Wardle, R.L., Bowman, P.D. and Paul, R.J. (2009. ) Hypoxic vasorelaxation in porcine coronary artery is not mediated by reactive oxygen species .

Nobe, K.; Nobe, H.; Yoshida, H.; Kolodney, M. S.; Paul, R. J.; Honda, K. (2010. ) Rho A and the Rho kinase pathway regulate fibroblast contraction: Enhanced contraction in constitutively active Rho A fibroblast cells .Biochemical and biophysical research communications, , 399 (2 ) ,292-9

Nobe, K., Yoshida, H.O., Nobe, H., Kolodney, M., Paul, R., Honda, K. (2009. ) Rho A and the Rho Kinase Pathway Regulate Fibroblast Contraction in Wound Healing:Enhanced Contraction in Dominant Active Rho A Fibroblast Cells Manuscript Number: C-00485-2006 .Manuscript Number: C-00485-2006

Mavi, P.; Rajavelu, P.; Rayapudi, M.; Paul, R. J.; Mishra, A. (2012. ) Esophageal functional impairments in experimental eosinophilic esophagitis .American journal of physiology. Gastrointestinal and liver physiology, , 302 (11 ) ,G1347-55

Paul, Richard J (2009. ) Regulation of smooth muscle contraction/relaxation: paradigm shifts and quantifying arrows.The Journal of physiology, , 587 (Pt 14 ) ,3413-4 More Information

Oloizia, Brian; Paul, Richard J (2008. ) Ca2+ clearance and contractility in vascular smooth muscle: evidence from gene-altered murine models.Journal of molecular and cellular cardiology, , 45 (3 ) ,347-62 More Information

Lorenz, John N; Loreaux, Elizabeth L; Dostanic-Larson, Iva; Lasko, Valerie; Schnetzer, J Renee; Paul, Richard J; Lingrel, Jerry B (2008. ) ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit.American journal of physiology. Heart and circulatory physiology, , 295 (1 ) ,H273-80 More Information

Martin, Colin A; Bernabe, Kathryn Q; Taylor, Janice A; Nair, Rajalakshmi; Paul, Richard J; Guo, Jun; Erwin, Christopher R; Warner, Brad W (2008. ) Resection-induced intestinal adaptation and the role of enteric smooth muscle.Journal of pediatric surgery, , 43 (6 ) ,1011-7 More Information

Lynch, Ronald M; Weber, Craig S; Nullmeyer, Kevin D; Moore, Edwin D W; Paul, Richard J (2008. ) Clearance of store-released Ca2+ by the Na+-Ca2+ exchanger is diminished in aortic smooth muscle from Na+-K+-ATPase alpha 2-isoform gene-ablated mice.American journal of physiology. Heart and circulatory physiology, , 294 (3 ) ,H1407-16 More Information

Pritchard, Tracy J; Parvatiyar, Michelle; Bullard, Daniel P; Lynch, Ronald M; Lorenz, John N; Paul, Richard J (2007. ) Transgenic mice expressing Na+-K+-ATPase in smooth muscle decreases blood pressure.American journal of physiology. Heart and circulatory physiology, , 293 (2 ) ,H1172-82 More Information

Martin, Anne F; Bhatti, Sunita; Pyne-Geithman, Gail J; Farjah, Mariam; Manaves, Vlasios; Walker, Lori; Franks, Roberta; Strauch, Arthur R; Paul, Richard J (2007. ) Expression and function of COOH-terminal myosin heavy chain isoforms in mouse smooth muscle.American journal of physiology. Cell physiology, , 293 (1 ) ,C238-45 More Information

Wardle, Robert L; Gu, Min; Ishida, Yukisato; Paul, Richard J (2007. ) Rho kinase is an effector underlying Ca2+-desensitizing hypoxic relaxation in porcine coronary artery.American journal of physiology. Heart and circulatory physiology, , 293 (1 ) ,H23-9 More Information

Prasad, Vikram; Okunade, Gbolahan; Liu, Li; Paul, Richard J; Shull, Gary E (2007. ) Distinct phenotypes among plasma membrane Ca2+-ATPase knockout mice.Annals of the New York Academy of Sciences, , 1099 ,276-86 More Information

Paul, Richard J; Bowman, Peggy Sue; Johnson, Jason; Martin, Anne F (2007. ) Effects of sex and estrogen on myosin COOH-terminal isoforms and contractility in rat aorta.American journal of physiology. Regulatory, integrative and comparative physiology, , 292 (2 ) ,R751-7 More Information

Liu, Li; Ishida, Yukisato; Okunade, Gbolahan; Pyne-Geithman, Gail J; Shull, Gary E; Paul, Richard J (2007. ) Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice.American journal of physiology. Cell physiology, , 292 (1 ) ,C423-31 More Information

Lorenz, John N; Arend, Lois J; Robitz, Rachel; Paul, Richard J; MacLennan, A John (2007. ) Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice.American journal of physiology. Regulatory, integrative and comparative physiology, , 292 (1 ) ,R440-6 More Information

Liu, Li; Ishida, Yukisato; Okunade, Gbolahan; Shull, Gary E; Paul, Richard J (2006. ) Role of plasma membrane Ca2+-ATPase in contraction-relaxation processes of the bladder: evidence from PMCA gene-ablated mice.American journal of physiology. Cell physiology, , 290 (4 ) ,C1239-47 More Information

Wardle, Robert L; Gu, Min; Ishida, Yukisato; Paul, Richard J (2006. ) Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery.The Journal of physiology, , 572 (Pt 1 ) ,259-67 More Information

Nobe, Koji; Sone, Tomoko; Paul, Richard J; Honda, Kazuo (2005. ) Thrombin-induced force development in vascular endothelial cells: contribution to alteration of permeability mediated by calcium-dependent and -independent pathways. Journal of pharmacological sciences, , 99 (3 ) ,252-63

Ishida, Yukisato; Paul, Richard J (2005. ) Ca2+ clearance in smooth muscle: lessons from gene-altered mice. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, , 41 (5 ) ,235-45

Dostanic, Iva; Paul, Richard J; Lorenz, John N; Theriault, Steven; Van Huysse, James W; Lingrel, Jerry B (2005. ) The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.American journal of physiology. Heart and circulatory physiology, , 288 (2 ) ,H477-85 More Information

Gu, Min; Thorne, George D; Wardle, Robert L; Ishida, Yukisato; Paul, Richard J (2005. ) Ca2+-independent hypoxic vasorelaxation in porcine coronary artery.The Journal of physiology, , 562 (Pt 3 ) ,839-46 More Information

Paul, R J; Zeis, B; Lamkemeyer, T; Seidl, M; Pirow, R (2004. ) Control of oxygen transport in the microcrustacean Daphnia: regulation of haemoglobin expression as central mechanism of adaptation to different oxygen and temperature conditions.Acta physiologica Scandinavica, , 182 (3 ) ,259-75 More Information

Radzyukevich, Tatiana L; Moseley, Amy E; Shelly, Daniel A; Redden, Gregory A; Behbehani, Michael M; Lingrel, Jerry B; Paul, Richard J; Heiny, Judith A (2004. ) The Na(+)-K(+)-ATPase alpha2-subunit isoform modulates contractility in the perinatal mouse diaphragm.American journal of physiology. Cell physiology, , 287 (5 ) ,C1300-10 More Information

Babu, Gopal J; Pyne, Gail J; Zhou, Yingbi; Okwuchukuasanya, Chris; Brayden, Joseph E; Osol, George; Paul, Richard J; Low, Robert B; Periasamy, Muthu (2004. ) Isoform switching from SM-B to SM-A myosin results in decreased contractility and altered expression of thin filament regulatory proteins.American journal of physiology. Cell physiology, , 287 (3 ) ,C723-9 More Information

Okunade, Gbolahan W; Miller, Marian L; Pyne, Gail J; Sutliff, Roy L; O'Connor, Kyle T; Neumann, Jonathan C; Andringa, Anastasia; Miller, Daniel A; Prasad, Vikram; Doetschman, Thomas; Paul, Richard J; Shull, Gary E (2004. ) Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.The Journal of biological chemistry, , 279 (32 ) ,33742-50 More Information

Sutliff, Roy L; Conforti, Laura; Weber, Craig S; Kranias, Evangelia G; Paul, Richard J (2004. ) Regulation of the spontaneous contractile activity of the portal vein by the sarcoplasmic reticulum: evidence from the phospholamban gene-ablated mouse.Vascular pharmacology, , 41 (6 ) ,197-204 More Information

Nobe, Koji; Suzuki, Hikaru; Sakai, Yasushi; Nobe, Hiromi; Paul, Richard J; Momose, Kazutaka (2004. ) Glucose-dependent enhancement of spontaneous phasic contraction is suppressed in diabetic mouse portal vein: association with diacylglycerol-protein kinase C pathway.The Journal of pharmacology and experimental therapeutics, , 309 (3 ) ,1263-72 More Information

Shelly, Daniel A; He, Suiwen; Moseley, Amy; Weber, Craig; Stegemeyer, Michelle; Lynch, Ronald M; Lingrel, Jerry; Paul, Richard J (2004. ) Na(+) pump alpha 2-isoform specifically couples to contractility in vascular smooth muscle: evidence from gene-targeted neonatal mice.American journal of physiology. Cell physiology, , 286 (4 ) ,C813-20 More Information

Thorne, George D; Hilliard, George M; Paul, Richard J (2004. ) Vascular oxygen sensing: detection of novel candidates by proteomics and organ culture.Journal of applied physiology (Bethesda, Md. : 1985), , 96 (2 ) ,802-8; discussion 79 More Information

Zeis, Bettina; Lamkemeyer, Tobias; Paul, Rüdiger J (2004. ) Molecular adaptation of Daphnia magna hemoglobin.Micron (Oxford, England : 1993), , 35 (1-2 ) ,47-9 More Information

Nobe, Hiromi; Nobe, Koji; Paul, Richard J (2003. ) Fibroblast fiber contraction: role of C and Rho kinase in activation by thromboxane A2.American journal of physiology. Cell physiology, , 285 (6 ) ,C1411-9 More Information

Wendt, Igor R; Paul, Richard J (2003. ) Energy cost of contraction in rat urinary bladder smooth muscle during anoxia. Clinical and experimental pharmacology & physiology, , 30 (8 ) ,565-9

McGraw, Dennis W; Almoosa, Khalid F; Paul, Richard J; Kobilka, Brian K; Liggett, Stephen B (2003. ) Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.The Journal of clinical investigation, , 112 (4 ) ,619-26 More Information

Thorne, George D; Paul, Richard J (2003. ) Effects of organ culture on arterial gene expression and hypoxic relaxation: role of the ryanodine receptor.American journal of physiology. Cell physiology, , 284 (4 ) ,C999-C1005 More Information

Nobe, Hiromi; Nobe, Koji; Fazal, Fabeha; De Lanerolle, Primal; Paul, Richard J (2003. ) Rho kinase mediates serum-induced contraction in fibroblast fibers independent of myosin LC20 phosphorylation.American journal of physiology. Cell physiology, , 284 (3 ) ,C599-606 More Information

Nobe, Koji; Sakai, Yasushi; Nobe, Hiromi; Takashima, Junko; Paul, Richard J; Momose, Kazutaka (2003. ) Enhancement effect under high-glucose conditions on U46619-induced spontaneous phasic contraction in mouse portal vein.The Journal of pharmacology and experimental therapeutics, , 304 (3 ) ,1129-42 More Information

Moseley, Amy E; Lieske, Steve P; Wetzel, Randall K; James, Paul F; He, Suiwen; Shelly, Daniel A; Paul, Richard J; Boivin, Gregory P; Witte, David P; Ramirez, Jan Marino; Sweadner, Kathleen J; Lingrel, Jerry B (2003. ) The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.The Journal of biological chemistry, , 278 (7 ) ,5317-24 More Information

Meyer, Jamie W; Flagella, Michael; Sutliff, Roy L; Lorenz, John N; Nieman, Michelle L; Weber, Craig S; Paul, Richard J; Shull, Gary E (2002. ) Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter.American journal of physiology. Heart and circulatory physiology, , 283 (5 ) ,H1846-55 More Information

Thorne, George D; Conforti, Laura; Paul, Richard J (2002. ) Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels.American journal of physiology. Heart and circulatory physiology, , 283 (1 ) ,H247-53 More Information

Bäumer, C; Pirow, R; Paul, R J (2002. ) Circulatory oxygen transport in the water flea Daphnia magna.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, , 172 (4 ) ,275-85 More Information

Szymanski, P T; Ferguson, D G; Paul, R J (2002. ) Polylysine binding to unphosphorylated smooth muscle myosin enhances formation and stabilizes myosin filaments in vitro. Acta physiologica Scandinavica, , 174 (4 ) ,337-46

Eldabi, Tillal; Irani, Zahir; Paul, Ray J (2002. ) A proposed approach for modelling health-care systems for understanding. Journal of management in medicine, , 16 (2-3 ) ,170-87

Paul, R J; Shull, G E; Kranias, E G (2002. ) The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice. Novartis Foundation symposium, , 246 ,228-38; discussion 2

Krane, C M; Fortner, C N; Hand, A R; McGraw, D W; Lorenz, J N; Wert, S E; Towne, J E; Paul, R J; Whitsett, J A; Menon, A G (2001. ) Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.Proceedings of the National Academy of Sciences of the United States of America, , 98 (24 ) ,14114-9 More Information

Babu, G J; Loukianov, E; Loukianova, T; Pyne, G J; Huke, S; Osol, G; Low, R B; Paul, R J; Periasamy, M (2001. ) Loss of SM-B myosin affects muscle shortening velocity and maximal force development.Nature cell biology, , 3 (11 ) ,1025-9 More Information

Pirow, R; Bäumer, C; Paul, R J (2001. ) Benefits of haemoglobin in the cladoceran crustacean Daphnia magna. The Journal of experimental biology, , 204 (Pt 20 ) ,3425-41

Nobe, K; Sutliff, R L; Kranias, E G; Paul, R J (2001. ) Phospholamban regulation of bladder contractility: evidence from gene-altered mouse models. The Journal of physiology, , 535 (Pt 3 ) ,867-78

He, S; Shelly, D A; Moseley, A E; James, P F; James, J H; Paul, R J; Lingrel, J B (2001. ) The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility. American journal of physiology. Regulatory, integrative and comparative physiology, , 281 (3 ) ,R917-25

Akar, F; Jiang, G; Paul, R J; O'Neill, W C (2001. ) Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle. American journal of physiology. Cell physiology, , 281 (2 ) ,C579-84

Fortner, C N; Breyer, R M; Paul, R J (2001. ) EP2 receptors mediate airway relaxation to substance P, ATP, and PGE2. American journal of physiology. Lung cellular and molecular physiology, , 281 (2 ) ,L469-74

Carr, A N; Sutliff, R L; Weber, C S; Allen, P B; Greengard, P; de Lanerolle, P; Kranias, E G; Paul, R J (2001. ) Is myosin phosphatase regulated in vivo by inhibitor-1? Evidence from inhibitor-1 knockout mice. The Journal of physiology, , 534 (Pt. 2 ) ,357-66

Thorne, G D; Shimizu, S; Paul, R J (2001. ) Hypoxic vasodilation in porcine coronary artery is preferentially inhibited by organ culture. American journal of physiology. Cell physiology, , 281 (1 ) ,C24-32

Nobe, K; Paul, R J (2001. ) Distinct pathways of Ca(2+) sensitization in porcine coronary artery: effects of Rho-related kinase and protein kinase C inhibition on force and intracellular Ca(2+). Circulation research, , 88 (12 ) ,1283-90

Fischer, D R; Sun, X; Williams, A B; Gang, G; Pritts, T A; James, J H; Molloy, M; Fischer, J E; Paul, R J; Hasselgren, P O (2001. ) Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. Shock (Augusta, Ga.), , 15 (3 ) ,200-7

Fortner, C N; Lorenz, J N; Paul, R J (2001. ) Chloride channel function is linked to epithelium-dependent airway relaxation. American journal of physiology. Lung cellular and molecular physiology, , 280 (2 ) ,L334-41

Zhao, G; Sutliff, R L; Weber, C S; Wang, J; Lorenz, J; Paul, R J; Fagin, J A (2001. ) Smooth muscle-targeted overexpression of insulin-like growth factor I results in enhanced vascular contractility. Endocrinology, , 142 (2 ) ,623-32

Nobe, K; Nobe, H; Obara, K; Paul, R J (2000. ) Preferential role of intracellular Ca2+ stores in regulation of isometric force in NIH 3T3 fibroblast fibres. The Journal of physiology, , 529 Pt 3 ,669-79

Paul, R J; Gohla, J; Föll, R; Schneckenburger, H (2000. ) Metabolic adaptations to environmental changes in Caenorhabditis elegans. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, , 127 (4 ) ,469-79

Paul, R J; Bowman, P S; Kolodney, M S (2000. ) Effects of microtubule disruption on force, velocity, stiffness and [Ca(2+)](i) in porcine coronary arteries. American journal of physiology. Heart and circulatory physiology, , 279 (5 ) ,H2493-501

Obara, K; Nobe, K; Nobe, H; Kolodney, M S; De Lanerolle, P; Paul, R J (2000. ) Effects of microtubules and microfilaments on [Ca(2+)](i) and contractility in a reconstituted fibroblast fiber. American journal of physiology. Cell physiology, , 279 (3 ) ,C785-96

Pelaez, N J; Braun, T R; Paul, R J; Meiss, R A; Packer, C S (2000. ) H(2)O(2) mediates Ca(2+)- and MLC(20) phosphorylation-independent contraction in intact and permeabilized vascular muscle. American journal of physiology. Heart and circulatory physiology, , 279 (3 ) ,H1185-93

Shimizu, S; Bowman, P S; Thorne, G; Paul, R J (2000. ) Effects of hypoxia on isometric force, intracellular Ca(2+), pH, and energetics in porcine coronary artery. Circulation research, , 86 (8 ) ,862-70

Galvin, K M; Donovan, M J; Lynch, C A; Meyer, R I; Paul, R J; Lorenz, J N; Fairchild-Huntress, V; Dixon, K L; Dunmore, J H; Gimbrone, M A; Falb, D; Huszar, D (2000. ) A role for smad6 in development and homeostasis of the cardiovascular system.Nature genetics, , 24 (2 ) ,171-4 More Information

McGraw, D W; Forbes, S L; Kramer, L A; Witte, D P; Fortner, C N; Paul, R J; Liggett, S B (1999. ) Transgenic overexpression of beta(2)-adrenergic receptors in airway smooth muscle alters myocyte function and ablates bronchial hyperreactivity. The Journal of biological chemistry, , 274 (45 ) ,32241-7

Föll, R L; Pleyers, A; Lewandovski, G J; Wermter, C; Hegemann, V; Paul, R J (1999. ) Anaerobiosis in the nematode Caenorhabditis elegans. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, , 124 (3 ) ,269-80

Brown, J; Karnon, J; Eldabi, T; Paul, R J (1999. ) Using modelling in a phased approach to the economic evaluation of adjuvant therapy for early breast cancer. ABC Trial Steering Committee. Critical reviews in oncology/hematology, , 32 (2 ) ,95-103

Goldmann, T; Becher, B; Wiedorn, K H; Pirow, R; Deutschbein, M E; Vollmer, E; Paul, R J (1999. ) Epipodite and fat cells as sites of hemoglobin synthesis in the branchiopod crustacean Daphnia magna. Histochemistry and cell biology, , 112 (5 ) ,335-9

Shimizu, S; Paul, R J (1999. ) Hypoxia and alkalinization inhibit endothelium-derived nitric oxide but not endothelium-derived hyperpolarizing factor responses in porcine coronary artery. The Journal of pharmacology and experimental therapeutics, , 291 (1 ) ,335-44

Lalli, M J; Shimizu, S; Sutliff, R L; Kranias, E G; Paul, R J (1999. ) [Ca2+]i homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice. The American journal of physiology, , 277 (3 Pt 2 ) ,H963-70

Kao, J; Fortner, C N; Liu, L H; Shull, G E; Paul, R J (1999. ) Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse tracheal smooth muscle. The American journal of physiology, , 277 (2 Pt 1 ) ,L264-70

James, J H; Wagner, K R; King, J K; Leffler, R E; Upputuri, R K; Balasubramaniam, A; Friend, L A; Shelly, D A; Paul, R J; Fischer, J E (1999. ) Stimulation of both aerobic glycolysis and Na(+)-K(+)-ATPase activity in skeletal muscle by epinephrine or amylin. The American journal of physiology, , 277 (1 Pt 1 ) ,E176-86

Akar, F; Skinner, E; Klein, J D; Jena, M; Paul, R J; O'Neill, W C (1999. ) Vasoconstrictors and nitrovasodilators reciprocally regulate the Na+-K+-2Cl- cotransporter in rat aorta. The American journal of physiology, , 276 (6 Pt 1 ) ,C1383-90

Sutliff, R L; Weber, C S; Qian, J; Miller, M L; Clemens, T L; Paul, R J (1999. ) Vasorelaxant properties of parathyroid hormone-related protein in the mouse: evidence for endothelium involvement independent of nitric oxide formation. Endocrinology, , 140 (5 ) ,2077-83

Qian, J; Lorenz, J N; Maeda, S; Sutliff, R L; Weber, C; Nakayama, T; Colbert, M C; Paul, R J; Fagin, J A; Clemens, T L (1999. ) Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle. Endocrinology, , 140 (4 ) ,1826-33

Maeda, S; Sutliff, R L; Qian, J; Lorenz, J N; Wang, J; Tang, H; Nakayama, T; Weber, C; Witte, D; Strauch, A R; Paul, R J; Fagin, J A; Clemens, T L (1999. ) Targeted overexpression of parathyroid hormone-related protein (PTHrP) to vascular smooth muscle in transgenic mice lowers blood pressure and alters vascular contractility. Endocrinology, , 140 (4 ) ,1815-25

Pirow, ; Wollinger, ; Paul, (1999. ) The importance of the feeding current for oxygen uptake in the water flea daphnia magna .The Journal of experimental biology, , 202 (Pt 5) ,553-62

Sutliff, R L; Hoying, J B; Kadambi, V J; Kranias, E G; Paul, R J (1999. ) Phospholamban is present in endothelial cells and modulates endothelium-dependent relaxation. Evidence from phospholamban gene-ablated mice. Circulation research, , 84 (3 ) ,360-4

Periasamy, M; Reed, T D; Liu, L H; Ji, Y; Loukianov, E; Paul, R J; Nieman, M L; Riddle, T; Duffy, J J; Doetschman, T; Lorenz, J N; Shull, G E (1999. ) Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. The Journal of biological chemistry, , 274 (4 ) ,2556-62

Bowman, P; Haikala, H; Paul, R J (1999. ) Levosimendan, a calcium sensitizer in cardiac muscle, induces relaxation in coronary smooth muscle through calcium desensitization. The Journal of pharmacology and experimental therapeutics, , 288 (1 ) ,316-25

Paul, R J (1998. ) The role of phospholamban and SERCA3 in regulation of smooth muscle-endothelial cell signalling mechanisms: evidence from gene-ablated mice. Acta physiologica Scandinavica, , 164 (4 ) ,589-97

Tosun, M; Paul, R J; Rapoport, R M (1998. ) Coupling of store-operated Ca++ entry to contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, , 285 (2 ) ,759-66

Tosun, M; Paul, R J; Rapoport, R M (1998. ) Role of extracellular Ca++ influx via L-type and non-L-type Ca++ channels in thromboxane A2 receptor-mediated contraction in rat aorta. The Journal of pharmacology and experimental therapeutics, , 284 (3 ) ,921-8

Zhou, M; Sutliff, R L; Paul, R J; Lorenz, J N; Hoying, J B; Haudenschild, C C; Yin, M; Coffin, J D; Kong, L; Kranias, E G; Luo, W; Boivin, G P; Duffy, J J; Pawlowski, S A; Doetschman, T (1998. ) Fibroblast growth factor 2 control of vascular tone. Nature medicine, , 4 (2 ) ,201-7

Tosun, M; Paul, R J; Rapoport, R M (1997. ) Intracellular Ca2+ elevation and contraction due to prostaglandin F2alpha in rat aorta. European journal of pharmacology, , 340 (2-3 ) ,203-8

Liu, L H; Paul, R J; Sutliff, R L; Miller, M L; Lorenz, J N; Pun, R Y; Duffy, J J; Doetschman, T; Kimura, Y; MacLennan, D H; Hoying, J B; Shull, G E (1997. ) Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. The Journal of biological chemistry, , 272 (48 ) ,30538-45

Obara, K; Bowman, P S; Ishida, Y; Paul, R J (1997. ) Effects of hypoxia on [Ca2+]i, pHi and myosin light chain phosphorylation in guinea-pig taenia caeci. The Journal of physiology, , 503 ( Pt 2) ,427-33

Wingard, C J; Paul, R J; Murphy, R A (1997. ) Energetic cost of activation processes during contraction of swine arterial smooth muscle. The Journal of physiology, , 501 ( Pt 1) ,213-23

Martin, A F; Bhatti, S; Paul, R J (1997. ) C-terminal isoforms of the myosin heavy chain and smooth muscle function. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, , 117 (1 ) ,3-11

Paul, R J; Murphy, R A (1997. ) Role of myosin isoforms in smooth muscle function. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, , 117 (1 ) ,1-2

Lalli, J; Harrer, J M; Luo, W; Kranias, E G; Paul, R J (1997. ) Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle. Circulation research, , 80 (4 ) ,506-13

Lorenz, J N; Paul, R J (1997. ) Dependence of Ca2+ channel currents on endogenous and exogenous sources of ATP in portal vein smooth muscle. The American journal of physiology, , 272 (2 Pt 2 ) ,H987-94

Pirow, R; Wollinger, F; Paul, R J (1997. ) Gas exchange and gas transport in a water breather of millimetre size. Advances in experimental medicine and biology, , 428 ,139-45

Lalli, M J; Obara, K; Paul, R J (1997. ) Vanadate oxidation activates contraction in skinned smooth muscle without myosin light chain phosphorylation. The American journal of physiology, , 272 (1 Pt 1 ) ,C278-88

Foy, R A; Shimizu, S; Paul, R J (1997. ) The effects of hypoxia on pHi in porcine coronary artery endothelium and smooth muscle. A novel method for measurements in endothelial cells in situ. Circulation research, , 80 (1 ) ,21-7

Shimizu, S; Paul, R J (1997. ) The endothelium-dependent, substance P relaxation of porcine coronary arteries resistant to nitric oxide synthesis inhibition is partially mediated by 4-aminopyridine-sensitive voltage-dependent K+ channels. Endothelium : journal of endothelial cell research, , 5 (4 ) ,287-95

Paul, R J; Townsend, J B (1997. ) Some legal and managerial strategies for managing healthcare fraud. Health marketing quarterly, , 14 (3 ) ,19-33

James, J H; Fang, C H; Schrantz, S J; Hasselgren, P O; Paul, R J; Fischer, J E (1996. ) Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis.The Journal of clinical investigation, , 98 (10 ) ,2388-97 More Information

Obara, K; Szymanski, P T; Tao, T; Paul, R J (1996. ) Effects of calponin on isometric force and shortening velocity in permeabilized taenia coli smooth muscle. The American journal of physiology, , 270 (2 Pt 1 ) ,C481-7

Aharonson-Daniel, L; Paul, R J; Hedley, A J (1996. ) Management of queues in out-patient departments: the use of computer simulation. Journal of management in medicine, , 10 (6 ) ,50-8, 3

Paul, R J; Schneckenburger, H (1996. ) Oxygen concentration and the oxidation-reduction state of yeast: determination of free/bound NADH and flavins by time-resolved spectroscopy. Die Naturwissenschaften, , 83 (1 ) ,32-5

Cai, S; Ferguson, D G; Martin, A F; Paul, R J (1995. ) Smooth muscle contractility is modulated by myosin tail-S2-LMM hinge region interaction. The American journal of physiology, , 269 (5 Pt 1 ) ,C1126-32

Obara, K; Nikcevic, G; Pestic, L; Nowak, G; Lorimer, D D; Guerriero, V; Elson, E L; Paul, R J; de Lanerolle, P (1995. ) Fibroblast contractility without an increase in basal myosin light chain phosphorylation in wild type cells and cells expressing the catalytic domain of myosin light chain kinase. The Journal of biological chemistry, , 270 (32 ) ,18734-7

Nagesetty, R; Paul, R J (1994. ) Effects of pHi on isometric force and [Ca2+]i in porcine coronary artery smooth muscle. Circulation research, , 75 (6 ) ,990-8

Wingard, C J; Paul, R J; Murphy, R A (1994. ) Dependence of ATP consumption on cross-bridge phosphorylation in swine carotid smooth muscle. The Journal of physiology, , 481 ( Pt 1) ,111-7

Zhang, C; Paul, R J (1994. ) Excitation-contraction coupling and relaxation in porcine carotid arteries are specifically dependent on glucose. The American journal of physiology, , 267 (5 Pt 2 ) ,H1996-2004

Lehaney, B; Paul, R J (1994. ) Using soft systems methodology to develop a simulation of out-patient services. Journal of the Royal Society of Health, , 114 (5 ) ,248-51

Close, L A; Bowman, P S; Paul, R J (1994. ) Reoxygenation-induced relaxation of coronary arteries. A novel endothelium-dependent mechanism. Circulation research, , 74 (5 ) ,870-81

Hardin, C D; Zhang, C; Kranias, E G; Steenaart, N A; Raeymaekers, L; Paul, R J (1993. ) Regulation of glycolytically fueled Ca2+ uptake in smooth muscle plasmalemmal vesicles by phosphorylation. The American journal of physiology, , 265 (4 Pt 2 ) ,H1326-33

Campbell, J D; Paul, R J (1993. ) Effects of diltiazem on force, [Ca2+]i, and energy metabolism in porcine coronary artery. Journal of cardiovascular pharmacology, , 22 (3 ) ,408-15

Szymanski, P T; Ferguson, D G; Paul, R J (1993. ) Polylysine activates smooth muscle myosin ATPase activity via induction of a 10S to 6S transition. The American journal of physiology, , 265 (2 Pt 1 ) ,C379-86

Hashimoto, M; Close, L A; Ishida, Y; Paul, R J (1993. ) Dependence of endothelium-mediated relaxation on oxygen and metabolism in porcine coronary arteries. The American journal of physiology, , 265 (1 Pt 2 ) ,H299-306

Motley, E D; Paul, R J; Matlib, M A (1993. ) Role of Na(+)-Ca2+ exchange in the regulation of vascular smooth muscle tension. The American journal of physiology, , 264 (4 Pt 2 ) ,H1028-40

Hewett, T E; Martin, A F; Paul, R J (1993. ) Correlations between myosin heavy chain isoforms and mechanical parameters in rat myometrium. The Journal of physiology, , 460 ,351-64

Zhang, C; Paul, R J; Kranias, E G (1992. ) Calmodulin stimulation of smooth muscle plasmalemmal vesicle Ca2+ uptake: direct or indirect effect? .The American journal of physiology, , 263 (2 Pt 2 ) ,H366-71

Szymanski, P T; Strauss, J D; Doerman, G; DiSalvo, J; Paul, R J (1992. ) Polylysine activates smooth muscle actin-myosin interaction without LC20 phosphorylation. The American journal of physiology, , 262 (6 Pt 1 ) ,C1446-55

Strauss, J D; de Lanerolle, P; Paul, R J (1992. ) Effects of myosin kinase inhibiting peptide on contractility and LC20 phosphorylation in skinned smooth muscle. The American journal of physiology, , 262 (6 Pt 1 ) ,C1437-45

Hardin, C D; Paul, R J (1992. ) Localization of two glycolytic enzymes in guinea-pig taenia coli. Biochimica et biophysica acta, , 1134 (3 ) ,256-9

Campbell, J D; Paul, R J (1992. ) The nature of fuel provision for the Na+,K(+)-ATPase in porcine vascular smooth muscle. The Journal of physiology, , 447 ,67-82

Hardin, C D; Raeymaekers, L; Paul, R J (1992. ) Comparison of endogenous and exogenous sources of ATP in fueling Ca2+ uptake in smooth muscle plasma membrane vesicles. The Journal of general physiology, , 99 (1 ) ,21-40

Lang, R J; Ozolins, I Z; Paul, R J (1991. ) Effects of okadaic acid and ATP gamma S on cell length and Ca(2+)-channel currents recorded in single smooth muscle cells of the guinea-pig taenia caeci. British journal of pharmacology, , 104 (2 ) ,331-6

de Lanerolle, P; Paul, R J (1991. ) Myosin phosphorylation/dephosphorylation and regulation of airway smooth muscle contractility. The American journal of physiology, , 261 (2 Pt 1 ) ,L1-14

De Lanerolle, P; Strauss, J D; Felsen, R; Doerman, G E; Paul, R J (1991. ) Effects of antibodies to myosin light chain kinase on contractility and myosin phosphorylation in chemically permeabilized smooth muscle. Circulation research, , 68 (2 ) ,457-65

Lang, R J; Paul, R J (1991. ) Effects of 2,3-butanedione monoxime on whole-cell Ca2+ channel currents in single cells of the guinea-pig taenia caeci. The Journal of physiology, , 433 ,1-24

Szymanski, P T; Paul, R J (1991. ) Polylysine: an activator of smooth muscle contractility. Advances in experimental medicine and biology, , 304 ,363-8

Paul, R J; Hewett, T E; Martin, A F (1991. ) Myosin heavy chain isoforms and smooth muscle function. Advances in experimental medicine and biology, , 304 ,139-45

Ishida, Y; Paul, R J (1990. ) Effects of hypoxia on high-energy phosphagen content, energy metabolism and isometric force in guinea-pig taenia caeci. The Journal of physiology, , 424 ,41-56

Ngai, J H; Roth, P S; Paul, R J (1990. ) Effects of endothelium on basal tone and agonist and O2 sensitivity in porcine coronary artery. The Journal of pharmacology and experimental therapeutics, , 252 (3 ) ,1053-9

Paul, R J (1990. ) Smooth muscle energetics and theories of cross-bridge regulation. The American journal of physiology, , 258 (2 Pt 1 ) ,C369-75

Close, L A; Paul, R J (1990. ) Characterization of an endothelial-dependent response to oxygen in porcine coronary artery. Progress in clinical and biological research, , 327 ,555-8

Paul, R J; Wendt, I R; Walker, J S; Gibbs, C L (1990. ) Smooth muscle energetics: testing theories of crossbridge regulation. Progress in clinical and biological research, , 327 ,29-38

Campbell, J D; Paul, R J (1990. ) Vascular smooth muscle: quantitation of Na(+)-pump activity and aerobic glycolysis. Progress in clinical and biological research, , 327 ,549-54

Strauss, J D; Szymanski, P T; Di Salvo, J; Paul, R J (1990. ) Effects of modulators of myosin phosphorylation on isometric force and shortening velocity in skinned smooth muscle. Progress in clinical and biological research, , 327 ,617-22

Lynch, R M; Kuettner, C P; Paul, R J (1989. ) Glycogen metabolism during tension generation and maintenance in vascular smooth muscle. The American journal of physiology, , 257 (4 Pt 1 ) ,C736-42

Paul, R J; Hardin, C D; Raeymaekers, L; Wuytack, F; Casteels, R (1989. ) Preferential support of Ca2+ uptake in smooth muscle plasma membrane vesicles by an endogenous glycolytic cascade. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 3 (11 ) ,2298-301

Rüegg, J C; Zeugner, C; Strauss, J D; Paul, R J; Kemp, B; Chem, M; Li, A Y; Hartshorne, D J (1989. ) A calmodulin-binding peptide relaxes skinned muscle from guinea-pig taenia coli. Pflügers Archiv : European journal of physiology, , 414 (3 ) ,282-5

Paul, R J (1989. ) Smooth muscle energetics.Annual review of physiology, , 51 ,331-49 More Information

Hashimoto, M; Ishida, Y; Paul, R J (1989. ) Low tension cost of the procine coronary artery under various metabolic conditions. Progress in clinical and biological research, , 315 ,467-8

Ishida, Y; Paul, R J (1989. ) Evidence for compartmentation of high energy phosphagens in smooth muscle. Progress in clinical and biological research, , 315 ,417-28

Paul, R J; Hardin, C; Campbell, J; Raeymaekers, L (1989. ) Compartmentation of metabolism and function in smooth muscle. Progress in clinical and biological research, , 315 ,381-90

Paul, R J; Rüegg, J C (1988. ) Role of magnesium in activation of smooth muscle. The American journal of physiology, , 255 (4 Pt 1 ) ,C465-72

Krisanda, J M; Paul, R J (1988. ) Dependence of force, velocity, and O2 consumption on [Ca2+]o in porcine carotid artery. The American journal of physiology, , 255 (3 Pt 1 ) ,C393-400

Lynch, R M; Paul, R J (1987. ) Compartmentation of carbohydrate metabolism in vascular smooth muscle. The American journal of physiology, , 252 (3 Pt 1 ) ,C328-34

Paul, R J; Strauss, J D; Krisanda, J M (1987. ) The effects of calcium on smooth muscle mechanics and energetics. Progress in clinical and biological research, , 245 ,319-32

Lynch, R M; Paul, R J (1986. ) Compartmentation of carbohydrate metabolism in vascular smooth muscle: evidence for at least two functionally independent pools of glucose 6-phosphate. Biochimica et biophysica acta, , 887 (3 ) ,315-8

McMahon, E G; Paul, R J (1986. ) Effects of forskolin and cyclic nucleotides on isometric force in rat aorta. The American journal of physiology, , 250 (3 Pt 1 ) ,C468-73

Rubanyi, G; Galvas, P; DiSalvo, J; Paul, R J (1986. ) Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP. The American journal of physiology, , 250 (3 Pt 1 ) ,C406-12

Martin, A F; Paul, R J; McMahon, E G (1986. ) Isomyosin transitions in ventricles of aldosterone-salt hypertensive rats. Hypertension, , 8 (2 ) ,128-32

Paul, R J; Lynch, R M; Krisanda, J M (1986. ) Vascular metabolism and energetics. Advances in experimental medicine and biology, , 194 ,375-87

McMahon, E G; Paul, R J (1986. ) Reversal of changes in metabolism and calcium sensitivity in aortas of rats recovered from aldosterone-salt hypertension. Blood vessels, , 23 (4-5 ) ,257-60

Rubanyi, G M; Paul, R J (1985. ) Modulation of beta adrenergic responsiveness by arachidonic acid metabolites in isolated bovine coronary arteries. The Journal of pharmacology and experimental therapeutics, , 234 (3 ) ,555-60

Mrwa, U; Güth, K; Rüegg, J C; Paul, R J; Boström, S; Barsotti, R; Hartshorne, D (1985. ) Mechanical and biochemical characterization of the contraction elicited by a calcium-independent myosin light chain kinase in chemically skinned smooth muscle. Experientia, , 41 (8 ) ,1002-6

Lynch, R M; Paul, R J (1985. ) Energy metabolism and transduction in smooth muscle. Experientia, , 41 (8 ) ,970-7

Hickey, K A; Rubanyi, G; Paul, R J; Highsmith, R F (1985. ) Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. The American journal of physiology, , 248 (5 Pt 1 ) ,C550-6

McMahon, E G; Paul, R J (1985. ) Calcium sensitivity of isometric force in intact and chemically skinned aortas during the development of aldosterone-salt hypertension in the rat. Circulation research, , 56 (3 ) ,427-35

Galvas, P E; Kuettner, C; Paul, R J; Di Salvo, J (1985. ) Temporal relationships between isometric force, phosphorylase, and protein kinase activities in vascular smooth muscle. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), , 178 (2 ) ,254-60

Rubanyi, G M; Paul, R J (1985. ) Alterations of arachidonic acid metabolism modulate adenosine relaxation in isolated coronary arteries. Blood vessels, , 22 (5 ) ,209-16

Rubanyi, G; Paul, R J (1985. ) Two distinct effects of oxygen on vascular tone in isolated porcine coronary arteries. Circulation research, , 56 (1 ) ,1-10

Lynch, R M; Paul, R J (1984. ) Glucose uptake in porcine carotid artery: relation to alterations in active Na+-K+ transport. The American journal of physiology, , 247 (5 Pt 1 ) ,C433-40

McMahon, E G; Paul, R J (1984. ) Metabolic and mechanical properties of aortas from aldosterone-salt hypertensive rats. Circulation research, , 55 (3 ) ,349-57

Rubanyi, G; Paul, R J (1984. ) O2-sensitivity of beta adrenergic responsiveness in isolated bovine and porcine coronary arteries. The Journal of pharmacology and experimental therapeutics, , 230 (3 ) ,692-8

Paul, R J; Hellstrand, P (1984. ) Dissociation of phosphorylase a activation and contractile activity in rat portal vein. Acta physiologica Scandinavica, , 121 (1 ) ,23-30

Krisanda, J M; Paul, R J (1984. ) Energetics of isometric contraction in porcine carotid artery. The American journal of physiology, , 246 (5 Pt 1 ) ,C510-9

Paul, R J; Krisanda, J M; Lynch, R M (1984. ) Vascular smooth muscle energetics. Journal of cardiovascular pharmacology, , 6 Suppl 2 ,S320-7

Lynch, R M; Paul, R J (1983. ) Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle. Science (New York, N.Y.), , 222 (4630 ) ,1344-6

Paul, R J; Doerman, G; Zeugner, C; Rüegg, J C (1983. ) The dependence of unloaded shortening velocity on Ca++, calmodulin, and duration of contraction in "chemically skinned" smooth muscle. Circulation research, , 53 (3 ) ,342-51

Paul, R J (1983. ) The effects of isoproterenol and ouabain on oxygen consumption, lactate production, and the activation of phosphorylase in coronary artery smooth muscle. Circulation research, , 52 (6 ) ,683-90

Paul, R J (1983. ) Functional compartmentalization of oxidative and glycolytic metabolism in vascular smooth muscle. The American journal of physiology, , 244 (5 ) ,C399-409

Krisanda, J M; Paul, R J (1983. ) Phosphagen and metabolite content during contraction in porcine carotid artery. The American journal of physiology, , 244 (5 ) ,C385-90

Hellstrand, P; Paul, R J (1983. ) Phosphagen content, breakdown during contraction, and O2 consumption in rat portal vein. The American journal of physiology, , 244 (3 ) ,C250-8

Paul, R J (1983. ) Physical and biochemical energy balance during an isometric tetanus and steady state recovery in frog sartorius at 0 degree C. The Journal of general physiology, , 81 (3 ) ,337-54

Solaro, R J; DiSalvo, J; Paul, R J (1983. ) Coordination of metabolism and contractility by phosphorylation in cardiac, skeletal, and smooth muscle. Introduction. Federation proceedings, , 42 (1 ) ,7-8

Paul, R J (1983. ) Coordination of metabolism and contractility in vascular smooth muscle. Federation proceedings, , 42 (1 ) ,62-6

Rüegg, J C; DiSalvo, J; Paul, R J (1982. ) Soluble relaxation factor from vascular smooth muscle: a myosin light chain phosphatase? .Biochemical and biophysical research communications, , 106 (4 ) ,1126-33

Rüegg, J C; Paul, R J (1982. ) Vascular smooth muscle. Calmodulin and cyclic AMP-dependent protein kinase after calcium sensitivity in porcine carotid skinned fibers. Circulation research, , 50 (3 ) ,394-9

Paul, R J (1982. ) Comparison of physical and biochemical energy balances: chemical breakdown, heat production, and oxygen consumption in frog sartorius muscle. Federation proceedings, , 41 (2 ) ,169-73

Gilloteaux, J; Paul, R J; Steggles, A W (1982. ) Upper genital tract abnormalities in the Syrian hamster as a result of in utero exposure to diethylstilbestrol. I. Uterine cystadenomatous papilloma and hypoplasia. Virchows Archiv. A, Pathological anatomy and histopathology, , 398 (2 ) ,163-83

Paul, R J; Bauer, M; Pease, W (1979. ) Vascular smooth muscle: aerobic glycolysis linked to sodium and potassium transport processes. Science (New York, N.Y.), , 206 (4425 ) ,1414-6

Glück, E; Paul, R J (1977. ) The aerobic metabolism of porcine carotid artery and its relationship to isometric force. Energy cost of isometric contraction. Pflügers Archiv : European journal of physiology, , 370 (1 ) ,9-18

Kushmerick, M J; Paul, R J (1977. ) Chemical energetics in repeated contractions of frog sartorius muscles at 0 degrees C. The Journal of physiology, , 267 (1 ) ,249-60

Paul, R J (1977. ) Comments on: oxygen tension sensors in vascular smooth muscle. Advances in experimental medicine and biology, , 78 ,117-22

Paul, R J (1976. ) Proceedings: Polarographic measurement of O2 consumption in frog sartorius muscle at 0 DEGREES C. The Journal of physiology, , 258 (2 ) ,47P-48P

Paul, R J; Glück, E; Rüegg, J C (1976. ) Cross bridge ATP utilization in arterial smooth muscle. Pflügers Archiv : European journal of physiology, , 361 (3 ) ,297-9

Kushmerick, M J; Paul, R J (1976. ) Relationship between initial chemical reactions and oxidative recovery metabolism for single isometric contractions of frog sartorius at 0 degrees C. The Journal of physiology, , 254 (3 ) ,711-27

Kushmerick, M J; Paul, R J (1976. ) Aerobic recovery metabolism following a single isometric tetanus in frog sartorius muscle at 0 degrees C. The Journal of physiology, , 254 (3 ) ,693-709

Paul, R J; Peterson, J W (1975. ) Relation between length, isometric force, and O2 consumption rate in vascular smooth muscle. The American journal of physiology, , 228 (3 ) ,915-22

Peterson, J W; Paul, R J (1974. ) Effects of initial length and active shortening on vascular smooth muscle contractility. The American journal of physiology, , 227 (5 ) ,1019-24

Peterson, J W; Paul, R J (1974. ) Aerobic glycolysis in vascular smooth muscle: relation to isometric tension. Biochimica et biophysica acta, , 357 (2 ) ,167-76

Paul, R J; Kushmerick, M J (1974. ) Apparent P-O ratio and chemical energy balance in frog sartorius muscle in vitro. Biochimica et biophysica acta, , 347 (3 ) ,483-90

Paul, R J; Peterson, J W; Caplan, S R (1974. ) A nonequilibrium thermodynamic description of vascular smooth muscle mechanochemistry. I. The rate of oxygen consumption: a measure of the driving chemical reaction. Journal of mechanochemistry & cell motility, , 3 (1 ) ,19-32

Paul, R J; Peterson, J W; Caplan, S R (1973. ) Oxygen consumption rate in vascular smooth muscle: relation to isometric tension. Biochimica et biophysica acta, , 305 (2 ) ,474-80

Shimizu, S; Shimizu, K; Paul, R J Cold storage induces an endothelium-independent relaxation to hypoxia/reoxygenation in porcine coronary arteries. Journal of vascular research, , 34 (5 ) ,399-407

Thorne, George D; Ishida, Yukisato; Paul, Richard J Hypoxic vasorelaxation: Ca2+-dependent and Ca2+-independent mechanisms.Cell calcium, , 36 (3-4 ) ,201-8 More Information

Shimizu, S; Yokoshiki, H; Sperelakis, N; Paul, R J Role of voltage-dependent and Ca(2+)-activated K(+) channels on the regulation of isometric force in porcine coronary artery. Journal of vascular research, , 37 (1 ) ,16-25

Bäumer, C; Pirow, R; Paul, R J Respiratory adaptations to running-water microhabitats in mayfly larvae Epeorus sylvicola and Ecdyonurus torrentis, Ephemeroptera.Physiological and biochemical zoology : PBZ, , 73 (1 ) ,77-85 More Information

Hashimoto, M; Ishida, Y; Naruse, I; Paul, R J Prolonged cold storage abolishes endothelium-dependent relaxing responses to A23187 and substance P in porcine coronary arteries. Journal of vascular research, , 29 (2 ) ,64-70

Ishida, Y; Riesinger, I; Wallimann, T; Paul, R J Compartmentation of ATP synthesis and utilization in smooth muscle: roles of aerobic glycolysis and creatine kinase. Molecular and cellular biochemistry, , 133-134 ,39-50

Nobe, Koji; Nobe, Hiromi; Yoshida, Hiroko; Kolodney, Michael S; Paul, Richard J; Honda, Kazuo (2010. ) Rho A and the Rho kinase pathway regulate fibroblast contraction: Enhanced contraction in constitutively active Rho A fibroblast cells.Biochemical and biophysical research communications, , 399 (2 ) ,292-9 More Information

Book Chapter

Burdyga, T. and Paul, R.J. (2012 ) Muscle: Calcium Signaling Muscle: Fundamental Biology and Mechanisms and Disease .Philadelphia, Elsevier

Paul, R.J. (2012 ) Contractility of Muscles Cell Physiology Source Book .(pp. 801 -822).New York, Academic

All SBP Ph.D. students Program Director

Sheila Masafi (Master ) Chair

Robert Littleton (Doctoral ) Committee Member

Josh Mammen (Doctoral ) Committee Member

Sunil Nair (Doctoral ) Committee Member

Arshani Wanspura (Doctoral ) Committee Member

Kelsey Bowman (Undergrad ) Advisor

Courtney Henz (Undergrad ) Advisor

(AAUP ) Treasurer Type:University/College Service Level:University

(AAUP ) Executive Board Type:University/College Service Level:University

(V.P. Health Affairs Environmental Quality Committee ) Committee Member Type:University/College Service Level:University

(Medical Scientist Training Program ) Member Type:University/College Service Level:College 2000 -To Present

(Physician Scientist Promotion Board ) Member Type:University/College Service Level:College 2005 -To Present

(PSTP Appeals Board ) Member Type:University/College Service Level:College

(Systems Biology & Physiology Ph.D. Program ) Director Type:University/College Service Level:College

(College Graduate Education Committee ) Member Type:University/College Service Level:College

(Executive Committee ) Committee Member Type:Departmental Service Level:Department

(Search Committee ) Committee Member Type:Departmental Service Level:Department

(Appointment, Reappointment, Promotion and Tenure Committee ) Committee Chair Type:Departmental Service Level:Department

(Workload Committee ) Committee Chair Type:Departmental Service Level:Department

American Journal of Physiology: Cell Physiology (Editorial Board ) Member Type:Service to Professional Associations Level:Prof. Org. 1984 -1993

American Journal of Physiology: Cell Physiology (Editorial Board ) Member Type:Service to Professional Associations Level:Prof. Org. 2005 -To Present

Molecular and Cellular Cardiology (Editorial Board ) Member Type:Service to Professional Associations Level:Prof. Org. 2000 -2008

Journal of Vascular Research (Editorial Board ) Member Type:Service to Professional Associations Level:Prof. Org. 1991 -To Present

Endothelium (Editorial Board ) Member Type:Service to Professional Associations Level:Prof. Org. 1992 -To Present

EB2009 Symposium: Novel Kinase Pathways Conference Organizer Type:Service to Professional Associations Level:Prof. Org.

Keystone Symposium, Vancouver Other Type:Service to Professional Associations Level:Prof. Org. -2009

American Physiological Society (Political Action Committee ) Committee Member Type:Public Level:Public 2007 -To Present

American Heart Association (Coordinator of Golf Outing ) Type:Public Level:Public 1994 -To Present

Member, Editorial Board, Frontiers in Vascular Physiology (2010-) Type:Service to Professional Associations Level:International

Musculoskeletal System(MeSH A02),Cardiovascular System(MeSH A07),Cells(MeSH A11),Vertebrates(MeSH B02),Musculoskeletal Diseases(MeSH C05),Respiratory Tract Diseases(MeSH C08),Urologic and Male Genital Diseases(MeSH C12),Cardiovascular Diseases(MeSH C14),Cardiovascular Agents(MeSH D18),Investigative Techniques(MeSH E05),Biochemical Phenomena, Metabolism, and Nutrition(MeSH G06),Physiological Processes(MeSH G07),Circulatory and Respiratory Physiology(MeSH G09),Musculoskeletal, Neural, and Ocular Physiology(MeSH G11),Education(MeSH I02)

Maintenance of my national recognition and visibility in terms of research is key to funding my research program. To this end, my approval by my peers as shown by reappointment to Am J Physiol. Cell and appointment to Frontiers in Vascular Physiology (2010-) Editorial Boards, my EB2009 Symposium and invited presentation at recent Keystone Symposium is encouraging.

Directorship of SBP Ph.D. Program

Management of Departmental Retreat.

Management of Workload Document

Management of Annual Review Protocols

Medical Physiology Level:Graduate

26-MCP-902 HUMAN SYS PHYS I Level:Graduate

26-MCP-849 STAT METHOD IN PHYS Level:Graduate

26-MCP-951 MOLECULAR PHYS I Level:Graduate