Jennifer Picarsic

Jennifer Picarsic , MD

Associate Professor of Clinical-Affiliate

Health UC - Georgetown

COM Pathology CCHMC Affiliate - 0529

Education

Medical Degree: University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, 2007 (Geriatric Medicine)

Bachelor of Science: Dickinson College Carlisle, Pennsylvania, 2003 (Biology)

Residency: University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania, 2007 (Anatomic and Clinical Pathology)

Fellowship: Children's Hospital of Pittsburgh of UPMC Pittsburgh, Pennsylvania, 2012 (Pediatrics)

Publications

Peer Reviewed Publications

Finn, Laura S; Picarsic, Jennifer; Knisely, A S (2024. ) Founders of Pediatric Pathology: Dr. Ron Jaffe (1943-2022) - An Appreciation.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, , 10935266231222712 More Information

Wilk, C Matthias; Cathomas, Flurin; Török, Orsolya; Le Berichel, Jessica; Park, Matthew D; Bigenwald, Camille; Heaton, George R; Hamon, Pauline; Troncoso, Leanna; Scull, Brooks P; Dangoor, Diana; Silvin, Aymeric; Fleischmann, Ryan; Belabed, Meriem; Lin, Howard; Merad Taouli, Elias; Boettcher, Steffen; Li, Long; Aubry, Antonio; Manz, Markus G; Kofler, Julia K; Yue, Zhenyu; Lira, Sergio A; Ginhoux, Florent; Crary, John F; McClain, Kenneth L; Picarsic, Jennifer L; Russo, Scott J; Allen, Carl E; Merad, Miriam (2023. ) Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.Immunity, , 56 (12 ) ,2790-2802.e6 More Information

Khorki, M Eyad; Shi, Tiffany; Cianciolo, Eileen E; Burg, Ashley R; Chukwuma, P Chukwunalu; Picarsic, Jennifer L; Morrice, Mary K; Woodle, E Steve; Maltzman, Jonathan S; Ferguson, Autumn; Katz, Jonathan D; Baker, Brian M; Hildeman, David A (2023. ) Prior viral infection primes cross-reactive CD8+ T cells that respond to mouse heart allografts.Frontiers in immunology, , 14 ,1287546 More Information

Pegoraro, Francesco; Mazzariol, Martina; Trambusti, Irene; Bakhshi, Sameer; Mallick, Saumyaranjan; Dunkel, Ira J; van den Bos, Cor; Tezol, Özlem; Shan, Shijun; Ocak, Suheyla; Giordano, Flavio; De Fusco, Carmela; Gaspari, Stefania; Buccoliero, Anna Maria; Coniglio, Maria Luisa; Buti, Elisa; Romagnani, Paola; Picarsic, Jennifer; Donadieu, Jean; Diamond, Eli L; Emile, Jean-François; Sieni, Elena; Haroche, Julien; Vaglio, Augusto (2023. ) Childhood-onset Erdheim-Chester disease in the molecular era: clinical phenotypes and long-term outcomes of 21 patients.Blood, , 142 (13 ) ,1167-1171 More Information

Cournoyer, Eily; Ferrell, Justin; Sharp, Susan; Ray, Anish; Jordan, Michael; Dandoy, Christopher; Grimley, Michael; Roy, Somak; Lorsbach, Robert; Merrow, Arnold C; Nelson, Adam; Bartlett, Allison; Picarsic, Jennifer; Kumar, Ashish (2023. ) Dabrafenib and trametinib in Langerhans cell histiocytosis and other histiocytic disorders.Haematologica, , More Information

Milne, Paul; Bomken, Simon; Slater, Olga; Kumar, Ashish; Nelson, Adam; Roy, Somak; Velazquez, Jessica; Mankad, Kshitij; Nicholson, James; Yeomanson, Dan; Grundy, Richard; Kamal, Ahmed; Penn, Anthony; Pears, Jane; Millen, Gerard; Morland, Bruce; Hayden, James; Lam, Jason; Madkhali, Maymoon; MacDonald, Jamie; Singh, Preeti; Pagan, Sarah; Rodriguez-Galindo, Carlos; Minkov, Milen; Donadieu, Jean; Picarsic, Jennifer; Allen, Carl; Bigley, Venetia; Collin, Matthew (2023. ) Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis.Blood advances, , 7 (10 ) ,2171-2176 More Information

Eldem, Irem; Picarsic, Jennifer; Kumar, Ashish; Mossé, Yaël P; Roberts, Kaleigh Filisa; Armstrong, Amy E; Sisk, Bryan A (2023. ) Lorlatinib use in an infant with thalamic ALK-positive histiocytosis.Pediatric blood & cancer, , e30378 More Information

Eckstein, Olive S; Picarsic, Jennifer; Allen, Carl E (2022. ) Histiocytic Disorders of Childhood.Pediatrics in review, , 43 (10 ) ,561-571 More Information

Khoury, Joseph D; Solary, Eric; Abla, Oussama; Akkari, Yassmine; Alaggio, Rita; Apperley, Jane F; Bejar, Rafael; Berti, Emilio; Busque, Lambert; Chan, John K C; Chen, Weina; Chen, Xueyan; Chng, Wee-Joo; Choi, John K; Colmenero, Isabel; Coupland, Sarah E; Cross, Nicholas C P; De Jong, Daphne; Elghetany, M Tarek; Takahashi, Emiko; Emile, Jean-Francois; Ferry, Judith; Fogelstrand, Linda; Fontenay, Michaela; Germing, Ulrich; Gujral, Sumeet; Haferlach, Torsten; Harrison, Claire; Hodge, Jennelle C; Hu, Shimin; Jansen, Joop H; Kanagal-Shamanna, Rashmi; Kantarjian, Hagop M; Kratz, Christian P; Li, Xiao-Qiu; Lim, Megan S; Loeb, Keith; Loghavi, Sanam; Marcogliese, Andrea; Meshinchi, Soheil; Michaels, Phillip; Naresh, Kikkeri N; Natkunam, Yasodha; Nejati, Reza; Ott, German; Padron, Eric; Patel, Keyur P; Patkar, Nikhil; Picarsic, Jennifer; Platzbecker, Uwe; Roberts, Irene; Schuh, Anna; Sewell, William; Siebert, Reiner; Tembhare, Prashant; Tyner, Jeffrey; Verstovsek, Srdan; Wang, Wei; Wood, Brent; Xiao, Wenbin; Yeung, Cecilia; Hochhaus, Andreas (2022. ) The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.Leukemia, , 36 (7 ) ,1703-1719 More Information

Goyal, Gaurav; Tazi, Abdellatif; Go, Ronald S; Rech, Karen L; Picarsic, Jennifer L; Vassallo, Robert; Young, Jason R; Cox, Christian W; Van Laar, Jan; Hermiston, Michelle L; Cao, Xin-Xin; Makras, Polyzois; Kaltsas, Gregory; Haroche, Julien; Collin, Matthew; McClain, Kenneth L; Diamond, Eli L; Girschikofsky, Michael (2022. ) International expert consensus recommendations for the diagnosis and treatment of Langerhans cell histiocytosis in adults.Blood, , 139 (17 ) ,2601-2621 More Information

Ramgopal, Archana; Segal, Julia; Mukhtar, Sabrina; Yu, Jenny; Picarsic, Jennifer; Tersak, Jean M; Allen, Steven W (2022. ) A chronic eyelid lesion in a child: multi-disciplinary approach to diagnosis, treatment and management of a highly atypical histiocytic lesion.Pediatric hematology and oncology, , 39 (2 ) ,180-186 More Information

Kemps, Paul G; Picarsic, Jennifer; Durham, Benjamin H; Hélias-Rodzewicz, Zofia; Hiemcke-Jiwa, Laura; van den Bos, Cor; van de Wetering, Marianne D; van Noesel, Carel J M; van Laar, Jan A M; Verdijk, Robert M; Flucke, Uta E; Hogendoorn, Pancras C W; Woei-A-Jin, F J Sherida H; Sciot, Raf; Beilken, Andreas; Feuerhake, Friedrich; Ebinger, Martin; Möhle, Robert; Fend, Falko; Bornemann, Antje; Wiegering, Verena; Ernestus, Karen; Méry, Tina; Gryniewicz-Kwiatkowska, Olga; Dembowska-Baginska, Bozenna; Evseev, Dmitry A; Potapenko, Vsevolod; Baykov, Vadim V; Gaspari, Stefania; Rossi, Sabrina; Gessi, Marco; Tamburrini, Gianpiero; Héritier, Sébastien; Donadieu, Jean; Bonneau-Lagacherie, Jacinthe; Lamaison, Claire; Farnault, Laure; Fraitag, Sylvie; Jullié, Marie-Laure; Haroche, Julien; Collin, Matthew; Allotey, Jackie; Madni, Majid; Turner, Kerry; Picton, Susan; Barbaro, Pasquale M; Poulin, Alysa; Tam, Ingrid S; El Demellawy, Dina; Empringham, Brianna; Whitlock, James A; Raghunathan, Aditya; Swanson, Amy A; Suchi, Mariko; Brandt, Jon M; Yaseen, Nabeel R; Weinstein, Joanna L; Eldem, Irem; Sisk, Bryan A; Sridhar, Vaishnavi; Atkinson, Mandy; Massoth, Lucas R; Hornick, Jason L; Alexandrescu, Sanda; Yeo, Kee Kiat; Petrova-Drus, Kseniya; Peeke, Stephen Z; Muñoz-Arcos, Laura S; Leino, Daniel G; Grier, David D; Lorsbach, Robert; Roy, Somak; Kumar, Ashish R; Garg, Shipra; Tiwari, Nishant; Schafernak, Kristian T; Henry, Michael M; van Halteren, Astrid G S; Abla, Oussama; Diamond, Eli L; Emile, Jean-François (2022. ) ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition.Blood, , 139 (2 ) ,256-280 More Information

Bove, Kevin E; Bernieh, Anas; Picarsic, Jennifer; Cox, Joseph P; Yang, Edmund; Mantor, Philip C; Thaker, Ameet; Lazar, Lauren; Sathe, Meghana; Megison, Stephen (2021. ) Hypoplasia of Extrahepatic Biliary Tree and Intrahepatic Cholangiolopathy in Cystic Fibrosis Imperfectly Mimic Biliary Atresia in 4 Infants With Cystic Fibrosis and Kasai Portoenterostomy.The American journal of surgical pathology, , 45 (11 ) ,1499-1508 More Information

McClain, Kenneth L; Bigenwald, Camille; Collin, Matthew; Haroche, Julien; Marsh, Rebecca A; Merad, Miriam; Picarsic, Jennifer; Ribeiro, Karina B; Allen, Carl E (2021. ) Histiocytic disorders.Nature reviews. Disease primers, , 7 (1 ) ,73 More Information

Jain, Payal; Surrey, Lea F; Straka, Joshua; Russo, Pierre; Womer, Richard; Li, Marilyn M; Storm, Phillip B; Waanders, Angela J; Hogarty, Michael D; Resnick, Adam C; Picarsic, Jennifer (2021. ) BRAF fusions in pediatric histiocytic neoplasms define distinct therapeutic responsiveness to RAF paradox breakers.Pediatric blood & cancer, , 68 (6 ) ,e28933 More Information

Muthiah, Nallammai; Nowicki, Kamil W; Picarsic, Jennifer L; D'Angelo, Michael P; Marker, Daniel F; Andrews, Edward G; Monaco, Edward A; Niranjan, Ajay (2021. ) Three decades of progress from surgery to medical therapy for isolated neuroaxis BRAF V600E-positive Langerhans cell histiocytosis management: illustrative case.Journal of neurosurgery. Case lessons, , 1 (19 ) ,CASE2118 More Information

Bigenwald, Camille; Le Berichel, Jessica; Wilk, C Matthias; Chakraborty, Rikhia; Chen, Steven T; Tabachnikova, Alexandra; Mancusi, Rebecca; Abhyankar, Harshal; Casanova-Acebes, Maria; Laface, Ilaria; Akturk, Guray; Jobson, Jenielle; Karoulia, Zoi; Martin, Jerome C; Grout, John; Rafiei, Anahita; Lin, Howard; Manz, Markus G; Baccarini, Alessia; Poulikakos, Poulikos I; Brown, Brian D; Gnjatic, Sacha; Lujambio, Amaia; McClain, Kenneth L; Picarsic, Jennifer; Allen, Carl E; Merad, Miriam (2021. ) BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology.Nature medicine, , 27 (5 ) ,851-861 More Information

Ferrell, Justin; Sharp, Susan; Kumar, Ashish; Jordan, Michael; Picarsic, Jennifer; Nelson, Adam (2021. ) Discrepancies between F-18-FDG PET/CT findings and conventional imaging in Langerhans cell histiocytosis.Pediatric blood & cancer, , 68 (4 ) ,e28891 More Information

Xiao, Yanling; van Halteren, Astrid G S; Lei, Xin; Borst, Jelske; Steenwijk, Eline; de Wit, Tom; Grabowska, Joanna; Voogd, Rhianne; Kemps, Paul; Picarsic, Jennifer; van den Bos, Cor; Borst, Jannie (2020. ) Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.Blood, , 136 (19 ) ,2188-2199 More Information

Tsoukas, Paul; Rapp, Emily; Van Der Kraak, Lauren; Weiss, Eric S; Dang, Vinh; Schneider, Corinne; Klein, Edwin; Picarsic, Jennifer; Salcedo, Rosalba; Stewart, C Andrew; Canna, Scott W (2020. ) Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation.Blood, , 136 (19 ) ,2162-2174 More Information

Lopez-Nunez, Oscar; Alaggio, Rita; Ranganathan, Sarangarajan; Schmitt, Lori; John, Ivy; Church, Alanna J; Picarsic, Jennifer (2020. ) New molecular insights into the pathogenesis of lipoblastomas: clinicopathologic, immunohistochemical, and molecular analysis in pediatric cases.Human pathology, , 104 ,30-41 More Information

Eissa, Shaimaa S; Clay, Michael R; Santiago, Teresa; Wu, Gang; Wang, Lu; Shulkin, Barry L; Picarsic, Jennifer; Nichols, Kim E; Campbell, Patrick K (2020. ) Dasatinib induces a dramatic response in a child with refractory juvenile xanthogranuloma with a novel MRC1-PDGFRB fusion.Blood advances, , 4 (13 ) ,2991-2995 More Information

Goyal, Gaurav; Heaney, Mark L; Collin, Matthew; Cohen-Aubart, Fleur; Vaglio, Augusto; Durham, Benjamin H; Hershkovitz-Rokah, Oshrat; Girschikofsky, Michael; Jacobsen, Eric D; Toyama, Kazuhiro; Goodman, Aaron M; Hendrie, Paul; Cao, Xin-Xin; Estrada-Veras, Juvianee I; Shpilberg, Ofer; Abdo, André; Kurokawa, Mineo; Dagna, Lorenzo; McClain, Kenneth L; Mazor, Roei D; Picarsic, Jennifer; Janku, Filip; Go, Ronald S; Haroche, Julien; Diamond, Eli L (2020. ) Erdheim-Chester disease: consensus recommendations for evaluation, diagnosis, and treatment in the molecular era.Blood, , 135 (22 ) ,1929-1945 More Information

Berklite, Lara; Ranganathan, Sarangarajan; John, Ivy; Picarsic, Jennifer; Santoro, Luisa; Alaggio, Rita (2020. ) Fibrous histiocytoma/dermatofibroma in children: the same as adults?.Human pathology, , 99 ,107-115 More Information

McClain, Kenneth L; Picarsic, Jennifer; Chakraborty, Rikhia; Zinn, Daniel; Lin, Howard; Abhyankar, Harshal; Scull, Brooks; Shih, Albert; Lim, Karen Phaik Har; Eckstein, Olive; Lubega, Joseph; Peters, Tricia L; Olea, Walter; Burke, Thomas; Ahmed, Nabil; Hicks, M John; Tran, Brandon; Jones, Jeremy; Dauser, Robert; Jeng, Michael; Baiocchi, Robert; Schiff, Deborah; Goldman, Stanton; Heym, Kenneth M; Wilson, Harry; Carcamo, Benjamin; Kumar, Ashish; Rodriguez-Galindo, Carlos; Whipple, Nicholas S; Campbell, Patrick; Murdoch, Geoffrey; Kofler, Julia; Heales, Simon; Malone, Marian; Woltjer, Randy; Quinn, Joseph F; Orchard, Paul; Kruer, Michael C; Jaffe, Ronald; Manz, Markus G; Lira, Sergio A; Parsons, D Williams; Merad, Miriam; Man, Tsz-Kwong; Allen, Carl E (2018. ) CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions.Cancer, , 124 (12 ) ,2607-2620 More Information

Weiss, Eric S; Girard-Guyonvarc'h, Charlotte; Holzinger, Dirk; de Jesus, Adriana A; Tariq, Zeshan; Picarsic, Jennifer; Schiffrin, Eduardo J; Foell, Dirk; Grom, Alexei A; Ammann, Sandra; Ehl, Stephan; Hoshino, Tomoaki; Goldbach-Mansky, Raphaela; Gabay, Cem; Canna, Scott W (2018. ) Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome.Blood, , 131 (13 ) ,1442-1455 More Information

Emile, Jean-François; Abla, Oussama; Fraitag, Sylvie; Horne, Annacarin; Haroche, Julien; Donadieu, Jean; Requena-Caballero, Luis; Jordan, Michael B; Abdel-Wahab, Omar; Allen, Carl E; Charlotte, Frédéric; Diamond, Eli L; Egeler, R Maarten; Fischer, Alain; Herrera, Juana Gil; Henter, Jan-Inge; Janku, Filip; Merad, Miriam; Picarsic, Jennifer; Rodriguez-Galindo, Carlos; Rollins, Barret J; Tazi, Abdellatif; Vassallo, Robert; Weiss, Lawrence M (2016. ) Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.Blood, , 127 (22 ) ,2672-81 More Information