Marvin W Tabor
The primary objective of the research program is to investigate the biochemical toxicology of xenobiotics, including hazardous wastes, isolated from complex environmental mixtures and from biological matrices. This program is comprised of three principalresearch areas:First, environmental chemistry, metabolic microbial biochemistry with the objective of the development, assessment, and optimization of the aerobic microbial degradation of hazardous wastes.Second, environmental analytical chemistry and bioanalytical toxicology with the objective of the development of analytical techniques to separate complex environmental mixtures and biological matrices into components that can be identified chemically and characterized biochemically as xenobiotics (including mutagens and carcinogens) and their metabolites.Third, mechanistic or metabolic biochemical toxicology with the objective of the elucidation of the pathways of biotransformation of xenobiotics and the mechanisms of biochemical (or chemical) toxicity for the metabolic intermediates of these compounds. This research program includes the development of trace analytical methods, employing techniques such as high-performance liquid chromatography (HPLC) and high-resolution mass spectrometry (HRMS) DS for the isolation, identification and quantitation of environmental biohazardous compounds or biochemical intermediates and metabolites of these compounds, for use in biochemical investigations of metabolism and mechanisms of action of xenobiotics, elucidation or optimization of the biodegradation of environmental biohazardous compounds, development and implementation of methods applicable to humans for analysis of biochemical indicators of environmental insults and exposures, and studies of xenobiotic biotransformations and their mechanisms of toxicity. This latter effort includes studies of the mechanisms of chemoprotection against environmental insults, and structure activity correlations of chemoprotection versus xenobiotic toxicity.
Grant: #5-R25-ES-08192-04-A0-S0-E0 Investigators:Tabor, Marvin 09-01-1996 -08-31-2000 National Institute of Environmental Health Sciences Risk and Choices: Teaching Environmental Health Science Role:PI $50,704.00 Closed Level:Federal
Chemistry,Analytical Chemistry,Environmental Analytical Chemistry,Toxicology,Toxicology,Biochemical Toxicology,Bacterial Metabolism,Environmental Response,Chromatography,Chemical Structure Determination,Mass Spectroscopy,Hazardous Waste,Detoxification of Hazardous Waste,Chemical Carcinogenesis,Structure Activity Relationship,Pharmacologic,Environmental Health,Industrial Health,Sampling,Analysis,Identification,Pollutant,Toxic Substance,Water Pollution,Water Sampling,Water Analysis