Patrick Tso , PhD

I am in the process of finishing a review chapter on intestinal lymphatics to be published this year by Nature Review Gastroenterology and Hepatollogy. Also will be published this year are two research paper in Nutrients describing the phenotype oc the male apoAIV knockout animal in the 129 strain and the other one the phenotypes of female animals in the 129 strain.  I anticipate that there will be one or two more additional papers that will be published this year.  on average, I spend 6 - 8 hrs either writing paper or reading literature per day.

Bachelor of Science: University of Western Australia Nedlands, Australia, 1973 (Physiology)

Doctorate: University of Western Australia Nedlands, Australia, 1978

One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine.

The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology.

We are currently studying how bile salts are involved in the absorption of lipids. In addition, we are also studying the factors regulating the synthesis and secretion of apolipoproteins by the small intestine.

The apolipoproteins we are studying are: apo AI, apo AIV, apo B, and apo CIII.  

- Professor, Department of Pathology and Laboratory Medicine, Metabolic Disease Institute Cincinnati - GRIA 271

Grant: #2 U24 DK059630-06 Investigators:Hui, David; Seeley, Randy; Sun, William; Tso, Patrick P.W. 09-01-2006 -05-31-2012 National Institute of Diabetes and Digestive and Kidney Diseases Cincinnati Mouse Metabolic Phenotyping Center Role:PI Active 000033-001 Level:Federal

Grant: #R01 ES014464 Investigators:Tso, Patrick P.W. 04-03-2007 -03-31-2011 National Institute of Environmental Health Sciences Interaction of Nutrient and Organochlorine Absorption Role:PI Active 002569-001 Level:Federal

Grant: #5-R01-DK-56910-05-A0-S0-E0 Investigators:Tso, Patrick P.W. 09-01-2000 -08-31-2006 National Institute of Diabetes and Digestive and Kidney Diseases Modulation of Intestinal Obesity Signals Role:PI Closed 003659-001 Level:Federal

Grant: #5-U24-DK-059630-01-A0-S0-E0 Investigators:Tso, Patrick P.W. 07-01-2001 -06-30-2007 National Institute of Diabetes and Digestive and Kidney Diseases Cincinnati Mouse Diabetes Role:PI Closed 003841-001 Level:Federal

Investigators:Tso, Patrick P.W. 09-01-2002 -08-31-2005 Department of Agriculture Toxic Lipophilic Xenobiotics: Tissue Distribution and Dietary Interactions Role:PI Closed 004089-001 Level:Federal

Grant: #5-R01-DK-53444-03-A0-S0-E0 Investigators:Tso, Patrick P.W. 09-15-1997 -07-31-2001 National Institute of Diabetes and Digestive and Kidney Diseases A Study of Hypothalamic Dysfunction in Zucker Obese Rats Role:PI Closed 004337-001 Level:Federal

Grant: #4-R01-DK-32288-14-A0-S0-E1 Investigators:Tso, Patrick P.W. 02-15-1997 -08-31-1999 National Institute of Diabetes and Digestive and Kidney Diseases Formation and Secretion of Intestinal Lipoproteins Role:PI Closed 004338-001 Level:Federal

Grant: #R01 DK076928 Investigators:Tso, Patrick P.W. 08-01-2007 -07-31-2012 National Institute of Diabetes and Digestive and Kidney Diseases Functional and Molecular Study of Intestinal Cholesterol Transporters and Absorption Role:PI Active 005055-001 Level:Federal

Grant: #T32 GM063483 Investigators:Tso, Patrick P.W. 07-01-2007 -06-30-2012 National Institute of General Medical Sciences Medical Scientist Training Program Role:PI Active 005326-001 Level:Federal

Grant: #R56 HD034089 Investigators:Davidson, William; Hui, David; Tso, Patrick P.W.; Woollett, Laura 09-01-2008 -08-31-2010 National Institute of Child Health and Human Development Sterol Metabolism During Pregnancy and Development Role:Collaborator Closed 005802-001 Level:Federal

Grant: #ZA02 Investigators:Tso, Patrick P.W. 12-29-2008 -12-28-2013 Abbott Laboratories Gastrointestinal Physiology Role:PI Active 006108-001 Level:Industry

Grant: #SRS 006117 Investigators:Tso, Patrick P.W. 02-01-2009 -01-31-2012 Ajinomoto Co., Inc. (Japan) Determination of the Effect of MSG on the Absorption of Lipids, Secretion of Incretins and Satiety Peptides involved in Gastrointestinal Function Role:PI Active 006117-001 Level:Foreign Industry

Grant: #3 R01 DK076928-03S1 Investigators:Tso, Patrick P.W. 08-15-2009 -05-31-2011 National Institute of Diabetes and Digestive and Kidney Diseases Functional & Molecular Study of Intestinal Cholesterol Transporters & Absorption Role:PI Active 006405-001 Level:Federal

Grant: #3 T32 GM063483-08S2 Investigators:Tso, Patrick P.W. 09-09-2009 -09-08-2011 National Institute of General Medical Sciences Medical Scientist Training Program Role:PI Active 006485-001 Level:Federal

Grant: #3 U24 DK059630-09S1 Investigators:Tso, Patrick P.W. 09-30-2009 -08-31-2011 National Institute of Diabetes and Digestive and Kidney Diseases Cincinnati Mouse Metabolic Phenotyping Center Role:PI Active 006537-001 Level:Federal

Grant: #SRS 006545 Investigators:Tso, Patrick P.W. 09-22-2009 -09-22-2011 BioKier, Inc. BioKier Study Role:PI Active 006545-001 Level:Industry

Grant: #HHMI 2010 Investigators:Tso, Patrick P.W. 07-01-2010 -06-30-2012 Howard Hughes Medical Institute Fellowship for Regan Memmott Role:PI Active 007154-001 Level:Private Non-Profit

Grant: #R01 DK092138 Investigators:Tso, Patrick P.W. 07-01-2011 -05-31-2015 National Institute of Diabetes and Digestive and Kidney Diseases Gut Mucosal Mast Cells are Activated by Fat Absorption: Physiology and Mechanism Role:PI Active 007413-001 Level:Federal

Grant: #U24 DK076169 Investigators:Obici, Silvana; Sakai, Randall; Tso, Patrick P.W. 09-15-2006 -12-31-2007 National Inst of Diabetes and Digestive and Kidney Disease Coordinating & Bioinformatics Unit for the AMDCC/MMPC P&F Program Role:PI $76,800.00 Closed Level:Federal

Grant: #1 R01 DK077170-01A2 Investigators:Howles, Philip; Hui, David; Tso, Patrick P.W. 09-30-2009 -05-31-2013 National Inst of Diabetes and Digestive and Kidney Disease Role of NPC1L1 in Regulating Energy Metabolism, Nutrient Utilization and Weight Gain Role:Collaborator $719,514.00 Active Level:Federal

Grant: #K01 DK087816 Investigators:Foster, Michelle; Tso, Patrick P.W.; Woods, Stephen 05-04-2010 -03-31-2014 National Inst of Diabetes and Digestive and Kidney Disease The Role of Visceral Fatty Acids in Relation to Insulin Resistance Role:Collaborator $156,891.00 Active Level:Federal

Grant: #U01 ES019480 Investigators:Belcher, Scott; Ben-Jonathan, Nira; Ho, Shuk Mei; Levin, Linda; Medvedovic, Mario; Miller, Marian; Stambrook, Peter; Tso, Patrick P.W. 09-22-2010 -05-31-2015 National Institute of Environmental Health Sciences Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk Role:Collaborator $1,790,100.00 Active Level:Federal

Grant: #F32DK091173 Investigators:Kohan, Alison; Tso, Patrick P.W. 03-01-2011 -02-28-2014 National Inst of Diabetes and Digestive and Kidney Disease The Regulation of Hepatic Lipid Metabolism by Apolipoprotein AIV Role:Collaborator $154,530.00 Active Level:Federal

Grant: #R01 DK092779 Investigators:Liu, Min; Tso, Patrick P.W.; Woods, Stephen 07-22-2011 -05-31-2016 National Inst of Diabetes and Digestive and Kidney Disease Brain ApoA-IV Mediates Estrogenic Reduction of Dietary Obesity in Female Rats Role:Collaborator $1,075,839.00 Active Level:Federal

Grant: #U24 DK059630 Investigators:Benoit, Stephen; Dalessio, David; Davidson, William; Howles, Philip; Hui, David; Jandacek, Ronald; Obici, Silvana; Schultz, Jo El; Seeley, Randy; Tschoep, Matthias; Tso, Patrick P.W.; Welge, Jeffrey; Woods, Stephen; Woollett, Laura 09-16-2011 -06-30-2016 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:PI $1,619,789.00 Active Level:Federal

Grant: #F30 HL097609 Investigators:Simpson, David Scott; Tso, Patrick P.W. 08-11-2011 -06-10-2012 National Heart, Lung and Blood Institute Role of RB/p16 Pathway in Pulmonary Progenitor Cell Regulation Role:Collaborator $41,088.00 Closed Level:Federal

Grant: #R01 DK103557 Investigators:Howles, Philip; Tso, Patrick P.W. 04-01-2015 -03-31-2020 National Inst of Diabetes and Digestive and Kidney Disease Apolipoprotein AV and intestinal transport Role:PI $379,161.00 Awarded Level:Federal

Grant: #U2CDK059630 Investigators:Benoit, Stephen; Davidson, William; Howles, Philip; Liu, Min; Reyes, Teresa; Tso, Patrick P.W.; Ulrich-Lai, Yvonne; Welge, Jeffrey; Woods, Stephen; Woollett, Laura 08-01-2016 -06-30-2021 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:PI $926,069.68 Active Level:Federal

Grant: #R01DK119135 Investigators:Liu, Min; Reyes, Teresa; Tso, Patrick P.W.; Ulrich-Lai, Yvonne; Woods, Stephen 09-20-2018 -05-31-2023 National Inst of Diabetes and Digestive and Kidney Disease Role of the GI lymphatic system in hormonal signaling and nutrient metabolism Role:PI $616,764.00 Active Level:Federal

Grant: #2018 Abbott Master Research Agreement Investigators:Tso, Patrick P.W. 12-03-2018 -12-02-2023 Abbott Laboratories Master Research Agreement Role:PI $.00 Active Level:Industry

Grant: #SOW 1_under Abbott Laboratories Master Agreement Investigators:Tso, Patrick P.W. 12-01-2018 -11-30-2019 Abbott Laboratories Evaluation of delivery vehicle effects upon tissue accretion of key lipid soluble nutrients Role:PI $211,372.00 Awarded Level:Industry

Grant: #ZB70-SOW under the Master Agreement Investigators:Tso, Patrick 01-07-2020 -01-31-2021 Abbott Laboratories Evaluation of structural and compositional lipid technologies upon nutrient absorption and deposition Role:PI $232,252.00 Awarded Level:Industry

Grant: #U2CDK059630 Investigators:Davidson, William; Liu, Min; Reyes, Teresa; Tso, Patrick; Ulrich-Lai, Yvonne 07-01-2021 -06-30-2026 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Shen, Ling; Wang, David Q-H; Tso, Patrick; Jandacek, Ronald J; Woods, Stephen C; Liu, Min (2011. ) Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus.Physiology & Behavior, , More Information

Clegg, Deborah J; Gotoh, Koro; Kemp, Christopher; Wortman, Matthew D; Benoit, Stephen C; Brown, Lynda M; D (2011. ) Consumption of a high-fat diet induces central insulin resistance independent of adiposity.Physiology & behavior, , 103 (1 ) ,10-6 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W (2011. ) Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: Relationship with stearoyl-CoA desaturase activity.Schizophrenia research, , More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W (2011. ) Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression.Schizophrenia research, , More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2011. ) Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats.European journal of pharmacology, , 652 (1-3 ) ,152-6 More Information

Kohan, Alison B; Qing, Yang; Cyphert, Holly A; Tso, Patrick; Salati, Lisa M (2011. ) Chylomicron remnants and nonesterified fatty acids differ in their ability to inhibit genes involved in lipogenesis in rats.The Journal of nutrition, , 141 (2 ) ,171-6 More Information

Kindel, Tammy L; Martins, Paulo J F; Yoder, Stephanie M; Jandacek, Ronald J; Seeley, Randy J; D (2011. ) Bypassing the duodenum does not improve insulin resistance associated with diet-induced obesity in rodents.Obesity (Silver Spring, Md.), , 19 (2 ) ,380-7 More Information

Yang, Li; Li, Xiaoming; Ji, Yong; Kohan, Alison B; Wang, David Q-H; Howles, Philip N; Hui, David Y; Lai, Jianghua; Tso, Patrick (2010. ) Effect of ezetimibe on incretin secretion in response to the intestinal absorption of a mixed meal.American journal of physiology. Gastrointestinal and liver physiology, , 299 (5 ) ,G1003-11 More Information

Kohan, Alison; Yoder, Stephanie; Tso, Patrick (2010. ) Lymphatics in intestinal transport of nutrients and gastrointestinal hormones.Annals of the New York Academy of Sciences, , 1207 Suppl 1 ,E44-51 More Information

Xiong, Ye; Shen, Ling; Liu, Kristina J; Tso, Patrick; Xiong, Yuqing; Wang, Guangji; Woods, Stephen C; Liu, Min (2010. ) Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats.Diabetes, , 59 (10 ) ,2505-12 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N (2010. ) Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder.Journal of affective disorders, , 126 (1-2 ) ,303-11 More Information

McNamara, Robert K; Able, Jessica A; Rider, Therese; Tso, Patrick; Jandacek, Ronald (2010. ) Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition.Progress in neuro-psychopharmacology & biological psychiatry, , 34 (7 ) ,1317-21 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Cole-Strauss, Allyson; Lipton, Jack W Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover.Prostaglandins, leukotrienes, and essential fatty acids, , 83 (4-6 ) ,185-91 More Information

Kohli, Rohit; Kirby, Michelle; Setchell, Kenneth D R; Jha, Pinky; Klustaitis, Kori; Woollett, Laura A; Pfluger, Paul T; Balistreri, William F; Tso, Patrick; Jandacek, Ronald J; Woods, Stephen C; Heubi, James E; Tschoep, Matthias H; D (2010. ) Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities.American journal of physiology. Gastrointestinal and liver physiology, , 299 (3 ) ,G652-60 More Information

Yoder, Stephanie M; Yang, Qing; Kindel, Tammy L; Tso, Patrick (2010. ) Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats.American journal of physiology. Gastrointestinal and liver physiology, , 299 (2 ) ,G476-85 More Information

Ellacott, Kate L J; Morton, Gregory J; Woods, Stephen C; Tso, Patrick; Schwartz, Michael W (2010. ) Assessment of feeding behavior in laboratory mice.Cell metabolism, , 12 (1 ) ,10-7 More Information

Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min (2010. ) Estradiol increases the anorectic effect of central apolipoprotein A-IV.Endocrinology, , 151 (7 ) ,3163-8 More Information

Kindel, Tammy; Lee, Dana M; Tso, Patrick (2010. ) The mechanism of the formation and secretion of chylomicrons.Atherosclerosis. Supplements, , 11 (1 ) ,11-6 More Information

Kindel, Tammy L; Yoder, Stephanie M; D'Alessio, David A; Tso, Patrick (2010. ) The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats.Obesity surgery, , 20 (6 ) ,768-75 More Information

Lo, Chun-Min; King, Alexandra; Samuelson, Linda C; Kindel, Tammy Lyn; Rider, Therese; Jandacek, Ronald J; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2010. ) Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity.Gastroenterology, , 138 (5 ) ,1997-2005 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Eliassen, James C; Alfieri, David; Weber, Wade; Jarvis, Kelly; DelBello, Melissa P; Strakowski, Stephen M; Adler, Caleb M (2010. ) Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study.The American journal of clinical nutrition, , 91 (4 ) ,1060-7 More Information

Dorsey, Jill; Buckley, Donna; Summer, Suzanne; Jandacek, Ronald J; Rider, Therese; Tso, Patrick; Narkewicz, Michael R; Heubi, James E (2010. ) Fat malabsorption in cystic fibrosis: comparison of quantitative fat assay and a novel assay using fecal lauric/behenic acid.Journal of pediatric gastroenterology and nutrition, , 50 (4 ) ,441-6 More Information

Yoder, Stephanie M; Kindel, Tammy L; Tso, Patrick (2010. ) Using the lymph fistula rat model to study incretin secretion.Vitamins and hormones, , 84 ,221-49 More Information

Kaplan, Kimberly; Dwivedi, Prabha; Davidson, Sean; Yang, Qing; Tso, Patrick; Siems, William; Hill, Herbert H (2009. ) Monitoring dynamic changes in lymph metabolome of fasting and fed rats by electrospray ionization-ion mobility mass spectrometry (ESI-IMMS).Analytical chemistry, , 81 (19 ) ,7944-53 More Information

Kindel, Tammy L; Yoder, Stephanie M; Seeley, Randy J; D'Alessio, David A; Tso, Patrick (2009. ) Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, , 13 (10 ) ,1762-72 More Information

Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min (2009. ) Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats.Physiology & behavior, , 98 (1-2 ) ,223-8 More Information

Yoder, Stephanie M; Yang, Qing; Kindel, Tammy L; Tso, Patrick (2009. ) Stimulation of incretin secretion by dietary lipid: is it dose dependent?.American journal of physiology. Gastrointestinal and liver physiology, , 297 (2 ) ,G299-305 More Information

Burke, Katie T; Horn, Paul S; Tso, Patrick; Heubi, James E; Woollett, Laura A (2009. ) Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels.American journal of physiology. Gastrointestinal and liver physiology, , 297 (1 ) ,G144-51 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2009. ) Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition.Psychoneuroendocrinology, , 34 (4 ) ,532-9 More Information

Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K (2009. ) Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition.Schizophrenia research, , 109 (1-3 ) ,113-20 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lindquist, Diana M (2009. ) Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study.Journal of lipid research, , 50 (3 ) ,405-11 More Information

McNamara, Robert K; Able, Jessica; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lipton, Jack W (2009. ) Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects.Journal of psychiatric research, , 43 (6 ) ,656-63 More Information

Kindel, Tammy L; Yang, Qing; Yoder, Stephanie M; Tso, Patrick (2009. ) Nutrient-driven incretin secretion into intestinal lymph is different between diabetic Goto-Kakizaki rats and Wistar rats.American journal of physiology. Gastrointestinal and liver physiology, , 296 (2 ) ,G168-74 More Information

Jandacek, Ronald J; Rider, Therese; Yang, Qing; Woollett, Laura A; Tso, Patrick (2009. ) Lymphatic and portal vein absorption of organochlorine compounds in rats.American journal of physiology. Gastrointestinal and liver physiology, , 296 (2 ) ,G226-34 More Information

McNamara, Robert K; Able, Jessica A; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2009. ) Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis.Schizophrenia research, , 107 (2-3 ) ,150-7 More Information

Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick (2009. ) Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration.American journal of physiology. Regulatory, integrative and comparative physiology, , 296 (1 ) ,R43-50 More Information

McNamara, Robert K; Able, Jessica; Jandacek, Ronald; Rider, Therese; Tso, Patrick (2009. ) Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid composition.Lipids, , 44 (1 ) ,1-8 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Roberts, Rosalinda C; Conley, Robert R; Pandey, Ghanshyam N (2009. ) Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims.Prostaglandins, leukotrienes, and essential fatty acids, , 80 (1 ) ,19-26 More Information

Battle, Michele A; Bondow, Benjamin J; Iverson, Moriah A; Adams, Scott J; Jandacek, Ronald J; Tso, Patrick; Duncan, Stephen A (2008. ) GATA4 is essential for jejunal function in mice.Gastroenterology, , 135 (5 ) ,1676-1686.e1 More Information

Labonté, Eric D; Camarota, Lisa M; Rojas, Juan C; Jandacek, Ronald J; Gilham, Dean E; Davies, Joanna P; Ioannou, Yiannis A; Tso, Patrick; Hui, David Y; Howles, Philip N (2008. ) Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.American journal of physiology. Gastrointestinal and liver physiology, , 295 (4 ) ,G776-83 More Information

McNamara, Robert K; Sullivan, Juliana; Richtand, Neil M; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Campbell, Nick; Lipton, Jack (2008. ) Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations.Synapse (New York, N.Y.), , 62 (10 ) ,725-35 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Hahn, Chang-Gyu; Richtand, Neil M (2008. ) Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder.Psychiatry research, , 160 (3 ) ,285-99 More Information

Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min (2008. ) Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis.Physiology & behavior, , 95 (1-2 ) ,161-7 More Information

Shen, Ling; Tso, Patrick; Woods, Stephen C; Clegg, Deborah J; Barber, Kyna L; Carey, Katherine; Liu, Min (2008. ) Brain apolipoprotein E: an important regulator of food intake in rats.Diabetes, , 57 (8 ) ,2092-8 More Information

Tubb, Matthew R; Silva, R A Gangani D; Fang, Jianwen; Tso, Patrick; Davidson, W Sean (2008. ) A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry.The Journal of biological chemistry, , 283 (25 ) ,17314-23 More Information

Lu, Wendell J; Yang, Qing; Sun, William; Woods, Stephen C; D'Alessio, David; Tso, Patrick (2008. ) Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose.American journal of physiology. Gastrointestinal and liver physiology, , 294 (5 ) ,G1130-8 More Information

McNamara, Robert K; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity.Prostaglandins, leukotrienes, and essential fatty acids, , 78 (4-5 ) ,293-304 More Information

Lo, Chun-Min; Samuelson, Linda C; Chambers, James Brad; King, Alexandra; Heiman, Justin; Jandacek, Ronald J; Sakai, Randall R; Benoit, Stephen C; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2008. ) Characterization of mice lacking the gene for cholecystokinin.American journal of physiology. Regulatory, integrative and comparative physiology, , 294 (3 ) ,R803-10 More Information

D'Alessio, David; Lu, Wendell; Sun, William; Zheng, Shuqin; Yang, Qing; Seeley, Randy; Woods, Stephen C; Tso, Patrick (2007. ) Fasting and postprandial concentrations of GLP-1 in intestinal lymph and portal plasma: evidence for selective release of GLP-1 in the lymph system.American journal of physiology. Regulatory, integrative and comparative physiology, , 293 (6 ) ,R2163-9 More Information

Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2007. ) Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 293 (4 ) ,R1490-4 More Information

Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean (2007. ) Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini.The Journal of biological chemistry, , 282 (39 ) ,28385-94 More Information

McNamara, Robert K; Hahn, Chang-Gyu; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Stanford, Kevin E; Richtand, Neil M (2007. ) Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder.Biological psychiatry, , 62 (1 ) ,17-24 More Information

Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min (2007. ) Hypothalamic apolipoprotein A-IV is regulated by leptin.Endocrinology, , 148 (6 ) ,2681-9 More Information

Jandacek, Ronald J; Tso, Patrick (2007. ) Enterohepatic circulation of organochlorine compounds: a site for nutritional intervention.The Journal of nutritional biochemistry, , 18 (3 ) ,163-7 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Hahn, Chang-Gyu; Richtand, Neil M; Stanford, Kevin E (2007. ) Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications.Schizophrenia research, , 91 (1-3 ) ,37-50 More Information

Lo, Chun-Min; Ma, Liyun; Zhang, Dian Ming; Lee, Rachel; Qin, Abby; Liu, Min; Woods, Stephen C; Sakai, Randall R; Raybould, Helen E; Tso, Patrick (2007. ) Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.American journal of physiology. Regulatory, integrative and comparative physiology, , 292 (1 ) ,R268-73 More Information

Duncan, Elizabeth A; Rider, Therese R; Jandacek, Ronald J; Clegg, Deborah J; Benoit, Stephen C; Tso, Patrick; Woods, Stephen C (2006. ) The regulation of alcohol intake by melanin-concentrating hormone in rats.Pharmacology, biochemistry, and behavior, , 85 (4 ) ,728-35 More Information

Nauli, Andromeda M; Nassir, Fatiha; Zheng, Shuqin; Yang, Qing; Lo, Chun-Min; Vonlehmden, Sarah B; Lee, Dana; Jandacek, Ronald J; Abumrad, Nada A; Tso, Patrick (2006. ) CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine.Gastroenterology, , 131 (4 ) ,1197-207 More Information

Trevaskis, Natalie L; Tso, Patrick; Rider, Therese; Charman, William N; Porter, Christopher J H; Jandacek, Ronald (2006. ) Tissue uptake of DDT is independent of chylomicron metabolism.Archives of toxicology, , 80 (4 ) ,196-200 More Information

Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C (2006. ) Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 290 (1 ) ,R202-7 More Information

Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean (2005. ) Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association.The Journal of biological chemistry, , 280 (46 ) ,38576-82 More Information

Proulx, Karine; Cota, Daniela; Castañeda, Tamara R; Tschöp, Matthias H; D'Alessio, David A; Tso, Patrick; Woods, Stephen C; Seeley, Randy J (2005. ) Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity.American journal of physiology. Regulatory, integrative and comparative physiology, , 289 (3 ) ,R729-37 More Information

Redgrave, Trevor G; Wallace, Peter; Jandacek, Ronald J; Tso, Patrick (2005. ) Treatment with a dietary fat substitute decreased Arochlor 1254 contamination in an obese diabetic male.The Journal of nutritional biochemistry, , 16 (6 ) ,383-4 More Information

Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean (2005. ) Bacterial expression and characterization of rat apolipoprotein E.Protein expression and purification, , 41 (2 ) ,447-53 More Information

Qin, Xiaofa; Shen, Hui; Liu, Min; Yang, Qing; Zheng, Shuqin; Sabo, Mary; D'Alessio, David A; Tso, Patrick (2005. ) GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.American journal of physiology. Gastrointestinal and liver physiology, , 288 (5 ) ,G943-9 More Information

Jandacek, Ronald J; Anderson, Nicole; Liu, Min; Zheng, Shuqin; Yang, Qing; Tso, Patrick (2005. ) Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene.American journal of physiology. Gastrointestinal and liver physiology, , 288 (2 ) ,G292-9 More Information

Tso, Patrick; Liu, Min (2004. ) Apolipoprotein A-IV, food intake, and obesity.Physiology & behavior, , 83 (4 ) ,631-43 More Information

Woods, Stephen C; D'Alessio, David A; Tso, Patrick; Rushing, Paul A; Clegg, Deborah J; Benoit, Stephen C; Gotoh, Koro; Liu, Min; Seeley, Randy J (2004. ) Consumption of a high-fat diet alters the homeostatic regulation of energy balance.Physiology & behavior, , 83 (4 ) ,573-8 More Information

Jandacek, Ronald J; Zheng, Shuqin; Yang, Qing; Tso, Patrick (2004. ) Rapid clearance of hexachlorobenzene from chylomicrons. Lipids, , 39 (10 ) ,993-5

Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean (2004. ) Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications.Biochemistry, , 43 (33 ) ,10719-29 More Information

Liu, Min; Shen, Ling; Liu, Yin; Woods, Stephen C; Seeley, Randy J; D'Alessio, David; Tso, Patrick (2004. ) Obesity induced by a high-fat diet downregulates apolipoprotein A-IV gene expression in rat hypothalamus.American journal of physiology. Endocrinology and metabolism, , 287 (2 ) ,E366-70 More Information

Liu, Min; Shen, Ling; Liu, Yin; Tajima, Daisuke; Sakai, Randall; Woods, Stephen C; Tso, Patrick (2004. ) Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone.Endocrinology, , 145 (7 ) ,3232-8 More Information

Jandacek, Ronald J; Heubi, James E; Tso, Patrick (2004. ) A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology, , 127 (1 ) ,139-44

Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J (2004. ) Apolipoprotein A-IV inhibits experimental colitis.The Journal of clinical investigation, , 114 (2 ) ,260-9 More Information

Tso, Patrick; Sun, William; Liu, Min (2004. ) Gastrointestinal satiety signals IV. Apolipoprotein A-IV.American journal of physiology. Gastrointestinal and liver physiology, , 286 (6 ) ,G885-90 More Information

Tso, Patrick; Liu, Min (2004. ) Ingested fat and satiety.Physiology & behavior, , 81 (2 ) ,275-87 More Information

Woollett, Laura A; Buckley, Donna D; Yao, Lihang; Jones, Peter J H; Granholm, Norman A; Tolley, Elizabeth A; Tso, Patrick; Heubi, James E (2004. ) Cholic acid supplementation enhances cholesterol absorption in humans. Gastroenterology, , 126 (3 ) ,724-31

Liu, Min; Doi, Takashi; Tso, Patrick (2003. ) Regulation of intestinal and hypothalamic apolipoprotein A-IV. Experimental biology and medicine (Maywood, N.J.), , 228 (10 ) ,1181-9

Clegg, Deborah J; Benoit, Stephen C; Air, Ellen L; Jackman, Alana; Tso, Patrick; D'Alessio, David; Woods, Stephen C; Seeley, Randy J (2003. ) Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology, , 144 (7 ) ,2941-6

Liu, Min; Shen, Ling; Doi, Takashi; Woods, Stephen C; Seeley, Randy J; Tso, Patrick (2003. ) Neuropeptide Y and lipid increase apolipoprotein AIV gene expression in rat hypothalamus. Brain research, , 971 (2 ) ,232-8

Nauli, Andromeda M; Zheng, Shuqin; Yang, Qing; Li, Ronggui; Jandacek, Ronald; Tso, Patrick (2003. ) Intestinal alkaline phosphatase release is not associated with chylomicron formation.American journal of physiology. Gastrointestinal and liver physiology, , 284 (4 ) ,G583-7 More Information

Woods, Stephen C; Seeley, Randy J; Rushing, Paul A; D'Alessio, David; Tso, Patrick (2003. ) A controlled high-fat diet induces an obese syndrome in rats. The Journal of nutrition, , 133 (4 ) ,1081-7

Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick (2003. ) Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, , 78 (1 ) ,149-55

Yao, Lihang; Heubi, James E; Buckley, Donna D; Fierra, Humberto; Setchell, Kenneth D R; Granholm, Norman A; Tso, Patrick; Hui, David Y; Woollett, Laura A (2002. ) Separation of micelles and vesicles within lumenal aspirates from healthy humans: solubilization of cholesterol after a meal. Journal of lipid research, , 43 (4 ) ,654-60

Kirby, R Jason; Zheng, Shuqin; Tso, Patrick; Howles, Philip N; Hui, David Y (2002. ) Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis.The Journal of biological chemistry, , 277 (6 ) ,4104-9 More Information

Tso, Patrick; Ding, Kexi; DeMichele, Stephen; Huang, Yung-Sheng (2002. ) Intestinal absorption and lymphatic transport of a high gamma-linolenic acid canola oil in lymph fistula Sprague-Dawley rats. The Journal of nutrition, , 132 (2 ) ,218-21

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; Strakowski, Stephen M; DelBello, Melissa P (2016. ) Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker.Early intervention in psychiatry, , 10 (3 ) ,203-11 More Information

Kassis, Timothy; Yarlagadda, Sri Charan; Kohan, Alison B; Tso, Patrick; Breedveld, Victor; Dixon, J Brandon (2016. ) Postprandial lymphatic pump function after a high-fat meal: a characterization of contractility, flow, and viscosity.American journal of physiology. Gastrointestinal and liver physiology, , 310 (10 ) ,G776-89 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Chu, Wen-Jang; Weber, Wade A; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P (2016. ) Effects of fish oil supplementation on prefrontal metabolite concentrations in adolescents with major depressive disorder: A preliminary (1)H MRS study.Nutritional neuroscience, , 19 (4 ) ,145-55 More Information

Rider, T; LeBoeuf, R C; Tso, Patrick; Jandacek, R J (2016. ) The Use of Kits in the Analysis of Tissue Lipids Requires Validation.Lipids, , 51 (4 ) ,497-504 More Information

Song, Chi Young; Ghafoor, Khuzema; Ghafoor, Hafiz U; Khan, Nayaab S; Thirunavukkarasu, Shyamala; Jennings, Brett L; Estes, Anne M; Zaidi, Sahar; Bridges, Dave; Tso, Patrick; Gonzalez, Frank J; Malik, Kafait U (2016. ) Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice.Hypertension, , 67 (1 ) ,206-13 More Information

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Blom, Thomas J; Welge, Jeffrey A; Strawn, Jeffrey R; Adler, Caleb M; DelBello, Melissa P; Strakowski, Stephen M (2015. ) First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine.Psychiatry research, , 230 (2 ) ,447-53 More Information

Zhang, Linda S; Sato, Hirokazu; Yang, Qing; Ryan, Robert O; Wang, David Q-H; Howles, Philip N; Tso, Patrick (2015. ) Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats.American journal of physiology. Gastrointestinal and liver physiology, , 309 (11 ) ,G918-25 More Information

Shen, Ling; Wang, David Q-H; Lo, Chunmin C; Arnold, Myrtha; Tso, Patrick; Woods, Stephen C; Liu, Min (2015. ) Gut vagal afferents are necessary for the eating-suppressive effect of intraperitoneally administered ginsenoside Rb1 in rats.Physiology & behavior, , 152 (Pt A ) ,62-7 More Information

Wang, Fei; Yoder, Stephanie M; Yang, Qing; Kohan, Alison B; Kindel, Tammy L; Wang, Jacob; Tso, Patrick (2015. ) Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weight.American journal of physiology. Gastrointestinal and liver physiology, , 309 (10 ) ,G807-15 More Information

Wang, Fei; Yang, Qing; Huesman, Sarah; Xu, Min; Li, Xiaoming; Lou, Danwen; Woods, Stephen C; Marziano, Corina; Tso, Patrick (2015. ) The role of apolipoprotein A-IV in regulating glucagon-like peptide-1 secretion.American journal of physiology. Gastrointestinal and liver physiology, , 309 (8 ) ,G680-7 More Information

Shen, Ling; Haas, Michael; Wang, David Q-H; May, Aaron; Lo, Chunmin C; Obici, Silvana; Tso, Patrick; Woods, Stephen C; Liu, Min (2015. ) Ginsenoside Rb1 increases insulin sensitivity by activating AMP-activated protein kinase in male rats.Physiological reports, , 3 (9 ) , More Information

Yan, Chunling; He, Yanlin; Xu, Yuanzhong; Shu, Gang; Wang, Chunmei; Yang, Yongjie; Saito, Kenji; Xu, Pingwen; Hinton, Antentor Othrell; Yan, Xiaofeng; Yu, Likai; Wu, Qi; Tso, Patrick; Tong, Qingchun; Xu, Yong (2015. ) Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates POMC Neurons in the Arcuate Nucleus.Neuroendocrinology, , More Information

Wang, Fei; Kohan, Alison B; Lo, Chun-Min; Liu, Min; Howles, Philip; Tso, Patrick (2015. ) Apolipoprotein A-IV: a protein intimately involved in metabolism.Journal of lipid research, , 56 (8 ) ,1403-18 More Information

Han, Shuxin; Han, Sean Shuxin; Zhang, Rongli; Jain, Rajan; Shi, Hong; Zhang, Lilei; Zhou, Guangjin; Sangwung, Panjamaporn; Tugal, Derin; Atkins, G Brandon; Prosdocimo, Domenick A; Lu, Yuan; Han, Xiaonan; Tso, Patrick; Liao, Xudong; Epstein, Jonathan A; Jain, Mukesh K (2015. ) Circadian control of bile acid synthesis by a KLF15-Fgf15 axis.Nature communications, , 6 ,7231 More Information

Zhang, Linda S; Xu, Min; Yang, Qing; Ryan, Robert O; Howles, Philip; Tso, Patrick (2015. ) Apolipoprotein A-V deficiency enhances chylomicron production in lymph fistula mice.American journal of physiology. Gastrointestinal and liver physiology, , 308 (7 ) ,G634-42 More Information

Zhang, Linda S; Xu, Min; Yang, Qing; Lou, Danwen; Howles, Philip N; Tso, Patrick (2015. ) ABCG5/G8 deficiency in mice reduces dietary triacylglycerol and cholesterol transport into the lymph.Lipids, , 50 (4 ) ,371-9 More Information

Kohan, Alison B; Wang, Fei; Lo, Chun-Min; Liu, Min; Tso, Patrick (2015. ) ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety.American journal of physiology. Gastrointestinal and liver physiology, , 308 (6 ) ,G472-81 More Information

Pressler, Josh W; Haller, April; Sorrell, Joyce; Wang, Fei; Seeley, Randy J; Tso, Patrick; Sandoval, Darleen A (2015. ) Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice.Diabetes, , 64 (2 ) ,498-507 More Information

Shen, Ling; Liu, Yin; Wang, David Q H; Tso, Patrick; Woods, Stephen C; Liu, Min (2014. ) Estradiol stimulates apolipoprotein A-IV gene expression in the nucleus of the solitary tract through estrogen receptor-?.Endocrinology, , 155 (10 ) ,3882-90 More Information

Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C (2014. ) Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats.Endocrinology, , 155 (5 ) ,1700-7 More Information

Poole, Daniel P; Lee, Mike; Tso, Patrick; Bunnett, Nigel W; Yo, Sek Jin; Lieu, TinaMarie; Shiu, Amy; Wang, Jen-Chywan; Nomura, Daniel K; Aponte, Gregory W (2014. ) Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system.American journal of physiology. Gastrointestinal and liver physiology, , 306 (8 ) ,G686-98 More Information

Jandacek, Ronald J; Heubi, James E; Buckley, Donna D; Khoury, Jane C; Turner, Wayman E; Sjödin, Andreas; Olson, James R; Shelton, Christie; Helms, Kim; Bailey, Tina D; Carter, Shirley; Tso, Patrick; Pavuk, Marian (2014. ) Reduction of the body burden of PCBs and DDE by dietary intervention in a randomized trial.The Journal of nutritional biochemistry, , 25 (4 ) ,483-8 More Information

McNamara, Robert K; Strimpfel, Jennifer; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Welge, Jeffrey A; Strawn, Jeffrey R; Delbello, Melissa P (2014. ) Detection and Treatment of Long-Chain Omega-3 Fatty Acid Deficiency in Adolescents with SSRI-Resistant Major Depressive Disorder.PharmaNutrition, , 2 (2 ) ,38-46 More Information

McNamara, Robert K; Rider, Therese; Jandacek, Ronald; Tso, Patrick (2014. ) Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis.Psychiatry research, , 215 (3 ) ,560-7 More Information

Wang, Fei; Kohan, Alison B; Dong, H Henry; Yang, Qing; Xu, Min; Huesman, Sarah; Lou, Danwen; Hui, David Y; Tso, Patrick (2014. ) Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymph.Physiological reports, , 2 (3 ) ,e00247 More Information

Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; McNamara, Robert K (2014. ) Omega-3 fatty acid deficient male rats exhibit abnormal behavioral activation in the forced swim test following chronic fluoxetine treatment: association with altered 5-HT1A and alpha2A adrenergic receptor expression.Journal of psychiatric research, , 50 ,42-50 More Information

Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean (2014. ) The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering.The Journal of biological chemistry, , 289 (9 ) ,5596-608 More Information

Ohlsson, Lena; Kohan, Alison B; Tso, Patrick; Ahrén, Bo (2014. ) GLP-1 released to the mesenteric lymph duct in mice: effects of glucose and fat.Regulatory peptides, , 189 ,40-5 More Information

Li, Xiaoming; Xu, Min; Wang, Fei; Kohan, Alison B; Haas, Michael K; Yang, Qing; Lou, Danwen; Obici, Silvana; Davidson, W Sean; Tso, Patrick (2014. ) Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.The Journal of biological chemistry, , 289 (4 ) ,2396-404 More Information

Trevaskis, Natalie L; Caliph, Suzanne M; Nguyen, Gary; Tso, Patrick; Charman, William N; Porter, Christopher J H (2013. ) A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport.Pharmaceutical research, , 30 (12 ) ,3254-70 More Information

McNamara, Robert K; Able, Jessica A; Liu, Yanhong; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Lipton, Jack W (2013. ) Omega-3 fatty acid deficiency does not alter the effects of chronic fluoxetine treatment on central serotonin turnover or behavior in the forced swim test in female rats.Pharmacology, biochemistry, and behavior, , 114-115 ,1-8 More Information

Zippin, Jonathan H; Chen, Yanqiu; Straub, Susanne G; Hess, Kenneth C; Diaz, Ana; Lee, Dana; Tso, Patrick; Holz, George G; Sharp, Geoffrey W G; Levin, Lonny R; Buck, Jochen (2013. ) CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.The Journal of biological chemistry, , 288 (46 ) ,33283-91 More Information

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Dwivedi, Yogesh; Ren, Xinguo; Pandey, Ghanshyam N (2013. ) Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease.Journal of psychiatric research, , 47 (9 ) ,1187-91 More Information

Wang, Fei; Pearson, Kevin J; Davidson, W Sean; Tso, Patrick (2013. ) Specific sequences in N termini of apolipoprotein A-IV modulate its anorectic effect.Physiology & behavior, , 120 ,136-42 More Information

McNamara, Robert K; Jandacek, Ronald; Tso, Patrick; Weber, Wade; Chu, Wen-Jang; Strakowski, Stephen M; Adler, Caleb M; Delbello, Melissa P (2013. ) Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study.Nutritional neuroscience, , 16 (4 ) ,183-90 More Information

Kohan, Alison B; Wang, Fei; Li, Xiaoming; Vandersall, Abbey E; Huesman, Sarah; Xu, Min; Yang, Qing; Lou, Danwen; Tso, Patrick (2013. ) Is apolipoprotein A-IV rate limiting in the intestinal transport and absorption of triglyceride?.American journal of physiology. Gastrointestinal and liver physiology, , 304 (12 ) ,G1128-35 More Information

Yeap, Yan Yan; Trevaskis, Natalie L; Quach, Tim; Tso, Patrick; Charman, William N; Porter, Christopher J H (2013. ) Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation.Molecular pharmaceutics, , 10 (5 ) ,1874-89 More Information

Ji, Yong; Sakata, Yasuhisa; Li, Xiaoming; Zhang, Chao; Yang, Qing; Xu, Min; Wollin, Armin; Langhans, Wolfgang; Tso, Patrick (2013. ) Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release.American journal of physiology. Gastrointestinal and liver physiology, , 304 (8 ) ,G732-40 More Information

Kohan, Alison B; Vandersall, Abbey E; Yang, Qing; Xu, Min; Jandacek, Ronald J; Tso, Patrick (2013. ) The transport of DDT from chylomicrons to adipocytes does not mimic triacylglycerol transport.Biochimica et biophysica acta, , 1831 (2 ) ,300-5 More Information

McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N (2013. ) Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk.Cardiovascular psychiatry and neurology, , 2013 ,796462 More Information

Lo, Chunmin C; Langhans, Wolfgang; Georgievsky, Maria; Arnold, Myrtha; Caldwell, Jody L; Cheng, Stacy; Liu, Min; Woods, Stephen C; Tso, Patrick (2012. ) Apolipoprotein AIV requires cholecystokinin and vagal nerves to suppress food intake.Endocrinology, , 153 (12 ) ,5857-65 More Information

Qin, Xiaofa; Dong, Wei; Sharpe, Susan M; Sheth, Sharvil U; Palange, David C; Rider, Therese; Jandacek, Ronald; Tso, Patrick; Deitch, Edwin A (2012. ) Role of lipase-generated free fatty acids in converting mesenteric lymph from a noncytotoxic to a cytotoxic fluid.American journal of physiology. Gastrointestinal and liver physiology, , 303 (8 ) ,G969-78 More Information

McNamara, Robert K; Magrisso, I Jack; Hofacer, Rylon; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C (2012. ) Omega-3 fatty acid deficiency augments risperidone-induced hepatic steatosis in rats: positive association with stearoyl-CoA desaturase.Pharmacological research, , 66 (4 ) ,283-91 More Information

Kohan, Alison B; Howles, Philip N; Tso, Patrick (2012. ) Methods for studying rodent intestinal lipoprotein production and metabolism.Current protocols in mouse biology, , 2 ,219-230 More Information

Kassis, Timothy; Kohan, Alison B; Weiler, Michael J; Nipper, Matthew E; Cornelius, Rachel; Tso, Patrick; Dixon, J Brandon (2012. ) Dual-channel in-situ optical imaging system for quantifying lipid uptake and lymphatic pump function.Journal of biomedical optics, , 17 (8 ) ,086005 More Information

Arnold, Myrtha; Dai, Yunting; Tso, Patrick; Langhans, Wolfgang (2012. ) Meal-contingent intestinal lymph sampling from awake, unrestrained rats.American journal of physiology. Regulatory, integrative and comparative physiology, , 302 (12 ) ,R1365-71 More Information

Wang, Fei; Kohan, Alison B; Kindel, Tammy L; Corbin, Kathryn L; Nunemaker, Craig S; Obici, Silvana; Woods, Stephen C; Davidson, W Sean; Tso, Patrick (2012. ) Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.Proceedings of the National Academy of Sciences of the United States of America, , 109 (24 ) ,9641-6 More Information

Ji, Yong; Sakata, Yasuhisa; Yang, Qing; Li, Xiaoming; Xu, Min; Yoder, Stephanie; Langhans, Wolfgang; Tso, Patrick (2012. ) Activation of rat intestinal mucosal mast cells by fat absorption.American journal of physiology. Gastrointestinal and liver physiology, , 302 (11 ) ,G1292-300 More Information

Yoshimichi, Go; Lo, Chunmin C; Tamashiro, Kellie L K; Ma, Liyun; Lee, Dana M; Begg, Denovan P; Liu, Min; Sakai, Randall R; Woods, Stephen C; Yoshimatsu, Hironobu; Tso, Patrick (2012. ) Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice.American journal of physiology. Gastrointestinal and liver physiology, , 302 (11 ) ,G1336-42 More Information

Tso, Patrick; Caldwell, Jody; Lee, Dana; Boivin, Gregory P; DeMichele, Stephen J (2012. ) Comparison of growth, serum biochemistries and n-6 fatty acid metabolism in rats fed diets supplemented with high-gamma-linolenic acid safflower oil or borage oil for 90 days.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, , 50 (6 ) ,1911-9 More Information

Lu, Wendell J; Yang, Qing; Yang, Li; Lee, Dana; D'Alessio, David; Tso, Patrick (2012. ) Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP.Lipids, , 47 (6 ) ,571-80 More Information

Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B (2012. ) The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.Structure (London, England : 1993), , 20 (5 ) ,767-79 More Information

Fei-Wang, ; Tian, De-Run; Tso, Patrick; Han, Ji-Sheng (2012. ) Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue.Peptides, , 35 (1 ) ,23-30 More Information

Kohan, Alison B; Wang, Fei; Li, Xiaoming; Bradshaw, Suzanne; Yang, Qing; Caldwell, Jody L; Bullock, Tera M; Tso, Patrick (2012. ) Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function.American journal of physiology. Gastrointestinal and liver physiology, , 302 (6 ) ,G628-36 More Information

Rebholz, Sandra L; Jones, Thomas; Burke, Katie T; Jaeschke, Anja; Tso, Patrick; D'Alessio, David A; Woollett, Laura A (2012. ) Multiparity leads to obesity and inflammation in mothers and obesity in male offspring.American journal of physiology. Endocrinology and metabolism, , 302 (4 ) ,E449-57 More Information

Hofacer, Rylon; Magrisso, I Jack; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Benoit, Stephen C; McNamara, Robert K Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels.Prostaglandins, leukotrienes, and essential fatty acids, , 86 (1-2 ) ,71-7 More Information

Fei Wang, ; Tian, De Run; Tso, Patrick; Han, Ji Sheng (2011. ) Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats.Peptides, , 32 (12 ) ,2394-9 More Information

Stefater, Margaret A; Sandoval, Darleen A; Chambers, Adam P; Wilson-Pérez, Hilary E; Hofmann, Susanna M; Jandacek, Ronald; Tso, Patrick; Woods, Stephen C; Seeley, Randy J (2011. ) Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion.Gastroenterology, , 141 (3 ) ,939-949.e1-4 More Information

Hofacer, Rylon; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Magrisso, I Jack; Benoit, Stephen C; McNamara, Robert K (2011. ) Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status.Nutrition research (New York, N.Y.), , 31 (9 ) ,715-22 More Information

Rebholz, Sandra L; Burke, Katie T; Yang, Qing; Tso, Patrick; Woollett, Laura A (2011. ) Dietary fat impacts fetal growth and metabolism: uptake of chylomicron remnant core lipids by the placenta.American journal of physiology. Endocrinology and metabolism, , 301 (2 ) ,E416-25 More Information

Lo, Chun-Min; Obici, Silvana; Dong, H Henry; Haas, Michael; Lou, Dawnwen; Kim, Dae Hyun; Liu, Min; D'Alessio, David; Woods, Stephen C; Tso, Patrick (2011. ) Impaired insulin secretion and enhanced insulin sensitivity in cholecystokinin-deficient mice.Diabetes, , 60 (7 ) ,2000-7 More Information

Zhang, Yupeng; He, Jing; Zhao, Jing; Xu, Min; Lou, Danwen; Tso, Patrick; Li, Zongfang; Li, Xiaoming (2017. ) Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes.Biochemical and biophysical research communications, , 487 (2 ) ,327-332 More Information

Rao, Raghavendra; Roche, Alexander; Febres, Gerardo; Bessler, Marc; Tso, Patrick; Korner, Judith (2017. ) Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, , 13 (3 ) ,468-473 More Information

Li, Xiaoming; Wang, Fei; Xu, Min; Howles, Philip; Tso, Patrick (2017. ) ApoA-IV improves insulin sensitivity and glucose uptake in mouse adipocytes via PI3K-Akt Signaling.Scientific reports, , 7 ,41289 More Information

Woods, Stephen C; May, Aaron A; Liu, Min; Tso, Patrick; Begg, Denovan P (2016. ) Using the cerebrospinal fluid to understand ingestive behavior.Physiology & behavior, , More Information

Sato, Hirokazu; Zhang, Linda S; Martinez, Kristina; Chang, Eugene B; Yang, Qing; Wang, Fei; Howles, Philip N; Hokari, Ryota; Miura, Soichiro; Tso, Patrick (2016. ) Antibiotics Suppress Activation of Intestinal Mucosal Mast Cells and Reduce Dietary Lipid Absorption in Sprague-Dawley Rats.Gastroenterology, , 151 (5 ) ,923-932 More Information

Kohan, Alison B; Yang, Qing; Xu, Min; Lee, Dana; Tso, Patrick (2016. ) Monosodium glutamate inhibits the lymphatic transport of lipids in the rat.American journal of physiology. Gastrointestinal and liver physiology, , 311 (4 ) ,G648-G654 More Information

Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2016. ) Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome.Journal of proteomics, , 146 ,184-94 More Information

Wang, David Q-H; Portincasa, Piero; Tso, Patrick (2017. ) Transintestinal cholesterol excretion: A secondary, nonbiliary pathway contributing to reverse cholesterol transport.Hepatology (Baltimore, Md.), , 66 (4 ) ,1337-1340 More Information

Packard, Amy E B; Zhang, Jintao; Myers, Brent; Ko, Chih-Wei; Wang, Fei; Tso, Patrick; Ulrich-Lai, Yvonne M (2017. ) Apolipoprotein A-IV constrains HPA and behavioral stress responsivity in a strain-dependent manner.Psychoneuroendocrinology, , 86 ,34-44 More Information

Zhang, Ming; Sun, Kaiji; Wu, Yujun; Yang, Ying; Tso, Patrick; Wu, Zhenlong (2017. ) Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease.Frontiers in immunology, , 8 ,942 More Information

Weng, Jonathan; Lou, Danwen; Benoit, Stephen C; Coschigano, Natalie; Woods, Stephen C; Tso, Patrick; Lo, Chunmin C (2017. ) Energy homeostasis in apolipoprotein AIV and cholecystokinin-deficient mice.American journal of physiology. Regulatory, integrative and comparative physiology, , ajpregu.00034.2017 More Information

Kweon, Soo-Mi; Irimia-Dominguez, Jose; Kim, Gayeoun; Fueger, Patrick T; Asahina, Kinji; Lai, Keith K; Allende, Daniela S; Lai, Quincy R; Lou, Chih-Hong; Tsark, Walter M; Yang, Ju Dong; Ng, Dominic S; Lee, Ju-Seog; Tso, Patrick; Huang, Wendong; Lai, Keane K Y (2023. ) Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose.American journal of physiology. Gastrointestinal and liver physiology, , 325 (2 ) ,G147-G157 More Information

Zhu, Qi; Qi, Nathan; Shen, Ling; Lo, Chunmin C; Xu, Meifeng; Duan, Qing; Ollberding, Nicholas J; Wu, Zhe; Hui, David Y; Tso, Patrick; Liu, Min (2023. ) Sexual Dimorphism in Lipid Metabolism and Gut Microbiota in Mice Fed a High-Fat Diet.Nutrients, , 15 (9 ) , More Information

LaRussa, Zachary; Kuo, Hsuan-Chih N; West, Kathryn; Shen, Zhijun; Wisniewski, Kevin; Tso, Patrick; Coschigano, Karen T; Lo, Chunmin C (2023. ) Increased BAT Thermogenesis in Male Mouse Apolipoprotein A4 Transgenic Mice.International journal of molecular sciences, , 24 (4 ) , More Information

Woo, Connie W; Tso, Patrick; Yiu, Jensen H C (2022. ) Commensal gut microbiota-based strategies for oral delivery of therapeutic proteins.Trends in pharmacological sciences, , 43 (12 ) ,1004-1013 More Information

He, Yu; Liu, Ning; Ji, Yun; Tso, Patrick; Wu, Zhenlong (2022. ) Weaning Stress in Piglets Alters the Expression of Intestinal Proteins Involved in Fat Absorption.The Journal of nutrition, , 152 (11 ) ,2387-2395 More Information

He, Yu; Song, Zhuan; Ji, Yun; Tso, Patrick; Wu, Zhenlong (2022. ) Preventive Effects of l-Glutamine on High-Fat Diet-Induced Metabolic Disorders Linking with Regulation of Intestinal Barrier Integrity, Hepatic Lipid Metabolism, and Gut Microbiota in Rats.Journal of agricultural and food chemistry, , 70 (38 ) ,11923-11934 More Information

May-Zhang, Linda; Liu, Min; Black, Dennis; Tso, Patrick (2022. ) Apolipoprotein A5, a unique modulator of fasting and postprandial triglycerides.Biochimica et biophysica acta. Molecular and cell biology of lipids, , 1867 (9 ) ,159185 More Information

He, Yu; Qu, Jie; Yang, Qing; Wu, Zhenlong; Liu, Min; Tso, Patrick (2022. ) Effect of L-Glutamine on Chylomicron Formation and Fat-Induced Activation of Intestinal Mucosal Mast Cells in Sprague-Dawley Rats.Nutrients, , 14 (9 ) , More Information

Zhu, Qi; Yang, Qing; Shen, Ling; Qu, Jie; Xu, Meifeng; Wang, David Q-H; Tso, Patrick; Liu, Min (2022. ) Impact of Sequential Lipid Meals on Lymphatic Lipid Absorption and Transport in Rats.Genes, , 13 (2 ) , More Information

Forman, Sarah; Tso, Patrick; Liu, Min (2022. ) Measurement of Hepatic Lipids.Methods in molecular biology (Clifton, N.J.), , 2455 ,41-48 More Information

Wang, David Q-H; Portincasa, Piero; Liu, Min; Tso, Patrick (2022. ) Overcoming Ductal Block: Emergency ERCP and Sphincterotomy Plus Common Bile Duct Stenting Improves Therapeutic Outcomes in Severe Gallstone Pancreatitis.Digestive diseases and sciences, , 67 (1 ) ,11-13 More Information

Liu, Min; Shen, Ling; Yang, Qing; Nauli, Andromeda M; Bingamon, Madison; Wang, David Q-H; Ulrich-Lai, Yvonne M; Tso, Patrick (2021. ) Sexual dimorphism in intestinal absorption and lymphatic transport of dietary lipids.The Journal of physiology, , 599 (22 ) ,5015-5030 More Information

Qu, Jie; Fourman, Sarah; Fitzgerald, Maureen; Liu, Min; Nair, Supna; Oses-Prieto, Juan; Burlingame, Alma; Morris, John H; Davidson, W Sean; Tso, Patrick; Bhargava, Aditi (2021. ) Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue.Scientific reports, , 11 (1 ) ,13289 More Information

Banan, Babak; Wei, Yan; Simo, Ornella; Tso, Patrick; Abumrad, Naji N; Flynn, Charles Robb; Sundaresan, Sinju; Albaugh, Vance L (2021. ) Intestinal Lymph Collection via Cannulation of the Mesenteric Lymphatic Duct in Mice.The Journal of surgical research, , 260 ,399-408 More Information

Liu, Min; Shen, Ling; Xu, Meifeng; Wang, David Q-H; Tso, Patrick (2020. ) Estradiol Enhances Anorectic Effect of Apolipoprotein A-IV through ERα-PI3K Pathway in the Nucleus Tractus Solitarius.Genes, , 11 (12 ) , More Information

Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H (2020. ) An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for Lith13.Genes, , 11 (12 ) , More Information

Liu, Min; Wang, David Q-H; Black, Dennis D; Tso, Patrick (2020. ) Differential Effect of Four-Week Feeding of Different Dietary Fats on the Accumulation of Fat and the Cholesterol and Triglyceride Contents in the Different Fat Depots.Nutrients, , 12 (11 ) , More Information

Yiu, Jensen H C; Chan, Kam-Suen; Cheung, Jamie; Li, Jin; Liu, Yan; Wang, Yao; Fung, William W L; Cai, Jieling; Cheung, Samson W M; Dorweiler, Bernhard; Wan, Eric Y F; Tso, Patrick; Xu, Aimin; Woo, Connie W (2020. ) Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver.Circulation research, , 127 (10 ) ,1236-1252 More Information

Mayer, Fahima; Gunawan, Amanda L; Tso, Patrick; Aponte, Gregory W (2020. ) Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide stimulate release of substance P from TRPV1- and TRPA1-expressing sensory nerves.American journal of physiology. Gastrointestinal and liver physiology, , 319 (1 ) ,G23-G35 More Information

Chen, Jingqing; Yang, Yuchen; Li, Shuai; Yang, Ying; Dai, Zhaolai; Wang, Fengchao; Wu, Zhenlong; Tso, Patrick; Wu, Guoyao (2020. ) E2F1 Regulates Adipocyte Differentiation and Adipogenesis by Activating ICAT.Cells, , 9 (4 ) , More Information

Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C (2020. ) Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation.Endocrinology, , 161 (4 ) , More Information

Ko, Chih-Wei; Qu, Jie; Black, Dennis D; Tso, Patrick (2020. ) Regulation of intestinal lipid metabolism: current concepts and relevance to disease.Nature reviews. Gastroenterology & hepatology, , 17 (3 ) ,169-183 More Information

Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean (2020. ) Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH.Journal of lipid research, , 61 (2 ) ,244-251 More Information

Zhou, Anna; Qu, Jie; Liu, Min; Tso, Patrick (2020. ) The Role of Interstitial Matrix and the Lymphatic System in Gastrointestinal Lipid and Lipoprotein Metabolism.Frontiers in physiology, , 11 ,4 More Information

Stahel, Priska; Xiao, Changting; Davis, Xenia; Tso, Patrick; Lewis, Gary F (2019. ) Glucose and GLP-2 (Glucagon-Like Peptide-2) Mobilize Intestinal Triglyceride by Distinct Mechanisms.Arteriosclerosis, thrombosis, and vascular biology, , 39 (8 ) ,1565-1573 More Information

AlSiraj, Yasir; Chen, Xuqi; Thatcher, Sean E; Temel, Ryan E; Cai, Lei; Blalock, Eric; Katz, Wendy; Ali, Heba M; Petriello, Michael; Deng, Pan; Morris, Andrew J; Wang, Xuping; Lusis, Aldons J; Arnold, Arthur P; Reue, Karen; Thompson, Katherine; Tso, Patrick; Cassis, Lisa A (2019. ) XX sex chromosome complement promotes atherosclerosis in mice.Nature communications, , 10 (1 ) ,2631 More Information

Ko, Chih-Wei; Qu, Jie; Tso, Patrick (2019. ) Editorial on Sramkova et al., "Apolipoprotein M: a novel adipokine decreasing with obesity and upregulated by calorie restriction".The American journal of clinical nutrition, , 109 (6 ) ,1495-1496 More Information

Qu, Jie; Ko, Chih-Wei; Tso, Patrick; Bhargava, Aditi (2019. ) Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against Atherosclerosis and Diabetes.Cells, , 8 (4 ) , More Information

Liu, Ning; Dai, Zhaolai; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Wu, Guoyao; Tso, Patrick; Wu, Zhenlong (2019. ) Maternal L-proline supplementation enhances fetal survival, placental development, and nutrient transport in mice†.Biology of reproduction, , 100 (4 ) ,1073-1081 More Information

Ko, Chih-Wei; Qu, Jie; Liu, Min; Black, Dennis D; Tso, Patrick (2019. ) Use of Isotope Tracers to Assess Lipid Absorption in Conscious Lymph Fistula Mice.Current protocols in mouse biology, , 9 (1 ) ,e60 More Information

Wang, Helen H; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H (2018. ) Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances.Liver research, , 2 (4 ) ,186-199 More Information

Ji, Yun; Dai, Zhaolai; Sun, Shiqiang; Ma, Xiaoshi; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong (2018. ) Hydroxyproline Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice: Involvment of the NF-κB Signaling and Oxidative Stress.Molecular nutrition & food research, , 62 (21 ) ,e1800494 More Information

Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu (2018. ) Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis.Nature communications, , 9 (1 ) ,3608 More Information

Liu, Min; Tso, Patrick; Woods, Stephen C (2018. ) Receptor CD36 links a risk-associated allele to obesity and metabolic disorders.The Journal of biological chemistry, , 293 (34 ) ,13349-13350 More Information

Zhang, Feng; Zarkada, Georgia; Han, Jinah; Li, Jinyu; Dubrac, Alexandre; Ola, Roxana; Genet, Gael; Boyé, Kevin; Michon, Pauline; Künzel, Steffen E; Camporez, Joao Paulo; Singh, Abhishek K; Fong, Guo-Hua; Simons, Michael; Tso, Patrick; Fernández-Hernando, Carlos; Shulman, Gerald I; Sessa, William C; Eichmann, Anne (2018. ) Lacteal junction zippering protects against diet-induced obesity.Science (New York, N.Y.), , 361 (6402 ) ,599-603 More Information

Langhans, Wolfgang; Adan, Roger; Arnold, Myrtha; Banks, William A; Card, J Patrick; Dailey, Megan J; Daniels, Derek; de Kloet, Annette D; de Lartigue, Guillaume; Dickson, Suzanne; Fedele, Shahana; Grill, Harvey J; Jansson, John-Olov; Kaufman, Sharon; Kolar, Grant; Krause, Eric; Lee, Shin J; Le Foll, Christelle; Levin, Barry E; Lutz, Thomas A; Mansouri, Abdelhak; Moran, Timothy H; Pacheco-López, Gustavo; Ramachandran, Deepti; Raybould, Helen; Rinaman, Linda; Samson, Willis K; Sanchez-Watts, Graciela; Seeley, Randy J; Skibicka, Karolina P; Small, Dana; Spector, Alan C; Tamashiro, Kellie L; Templeton, Brian; Trapp, Stefan; Tso, Patrick; Watts, Alan G; Weissfeld, Nadja; Williams, Diana; Wolfrum, Christian; Yosten, Gina; Woods, Stephen C (2018. ) New horizons for future research - Critical issues to consider for maximizing research excellence and impact.Molecular metabolism, , 14 ,53-59 More Information

Whitt, Jordan; Woo, Vivienne; Lee, Patrick; Moncivaiz, Jessica; Haberman, Yael; Denson, Lee; Tso, Patrick; Alenghat, Theresa (2018. ) Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice.Gastroenterology, , 155 (2 ) ,501-513 More Information

Tso, Patrick; Vurma, Mustafa; Ko, Chih-Wei; Lee, Dana; DeMichele, Stephen (2018. ) Effect of mono- and diglycerides on the digestion and absorption of lutein in lymph fistula rats.American journal of physiology. Gastrointestinal and liver physiology, , 315 (1 ) ,G95-G103 More Information

Wang, Tony Y; Portincasa, Piero; Liu, Min; Tso, Patrick; Wang, David Q-H (2018. ) Mouse models of gallstone disease.Current opinion in gastroenterology, , 34 (2 ) ,59-70 More Information

Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min (2018. ) Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression.The Journal of biological chemistry, , 293 (6 ) ,2091-2101 More Information

Ma, Xiaoshi; Dai, Zhaolai; Sun, Kaiji; Zhang, Yunchang; Chen, Jingqing; Yang, Ying; Tso, Patrick; Wu, Guoyao; Wu, Zhenlong (2017. ) Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review.Frontiers in immunology, , 8 ,1271 More Information

Wang, Helen H; Li, Tiangang; Portincasa, Piero; Ford, David A; Neuschwander-Tetri, Brent A; Tso, Patrick; Wang, David Q-H (2017. ) New insights into the role of Lith genes in the formation of cholesterol-supersaturated bile.Liver research, , 1 (1 ) ,42-53 More Information

Academic - Metabolic Diseases Institute
2120 Galbraith Road
Reading  Ohio, 45215
Phone: (513) 558-2151
patrick.tso@uc.edu