Syn Yeo

Syn Yeo , PhD

Instructor

Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati, Ohio 45267-0521
Email yeosn@ucmail.uc.edu

Education

Ph.D.: Cardiff University

BSc and MRes: Imperial College London

Postdoctoral training: University of Michigan

Research and Practice Interests

Current research projects examine the role of FIP200 and autophagy in breast cancer. General interest in intra-tumoral heterogeneity (non genetic, cell states, cancer stem cells) and strategies to sensitize breast cancers to immune checkpoint inhibitors.

Publications

Peer Reviewed Publications

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin (2018. ) Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.Autophagy, , 14 (7 ) ,1214-1225 More Information

Yeo, Syn Kok; Guan, Jun-Lin (2017. ) Breast Cancer: Multiple Subtypes within a Tumor?.Trends in cancer, , 3 (11 ) ,753-760 More Information

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin (2017. ) Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.The Journal of cell biology, , 216 (8 ) ,2581-2596 More Information

Yeo, Syn Kok; French, Rhiannon; Spada, Filomena; Clarkson, Richard (2017. ) Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells.Breast cancer research and treatment, , 162 (3 ) ,465-477 More Information

Yeo, Syn Kok; Guan, Jun-Lin (2016. ) Hierarchical heterogeneity in mammary tumors and its regulation by autophagy.Autophagy, , 12 (10 ) ,1960-1961 More Information

Yeo, Syn Kok; Wen, Jian; Chen, Song; Guan, Jun-Lin (2016. ) Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgf?/Smad Signaling.Cancer research, , 76 (11 ) ,3397-410 More Information

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin (2016. ) Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.Genes & development, , 30 (7 ) ,856-69 More Information

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. ) Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, , 212 (5 ) ,545-60 More Information

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin (2015. ) Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis.Breast cancer research and treatment, , 149 (3 ) ,619-29 More Information

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. ) Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, , 212 (7 ) ,879 More Information

Yeo, Syn Kok; Ali, Ahmed Y; Hayward, Olivia A; Turnham, Daniel; Jackson, Troy; Bowen, Ifor D; Clarkson, Richard (2016. ) ?-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines.Phytotherapy research : PTR, , 30 (3 ) ,418-25 More Information

Aydar, Ebru; Yeo, Syn; Djamgoz, Mustafa; Palmer, Christopher (2009. ) Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy.Cancer cell international, , 9 ,23 More Information

Wu, Hsin-Jung; Hao, Mingang; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication.Oncogene, , More Information

Okamoto, Takako; Yeo, Syn Kok; Hao, Mingang; Copley, Mary Rose; Haas, Michael A; Chen, Song; Guan, Jun-Lin (2020. ) FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.Cancer research, , 80 (17 ) ,3580-3592 More Information

Yeo, Syn Kok; Wang, Chenran; Guan, Jun-Lin (2020. ) Role of FIP200 in inflammatory processes beyond its canonical autophagy function.Biochemical Society transactions, , 48 (4 ) ,1599-1607 More Information

Yeo, Syn Kok; Zhu, Xiaoting; Okamoto, Takako; Hao, Mingang; Wang, Cailian; Lu, Peixin; Lu, Long Jason; Guan, Jun-Lin (2020. ) Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer.eLife, , 9 , More Information

Yeo, Syn Kok; Guan, Jun-Lin (2020. ) Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function.Cell stress, , 4 (8 ) ,216-217 More Information

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) Correction to: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, , 22 (1 ) ,71 More Information

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, , 22 (1 ) ,59 More Information

Yang, Fuchun; Sun, Shaogang; Wang, Chenran; Haas, Michael; Yeo, Syn; Guan, Jun-Lin (2020. ) Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.British journal of cancer, , 122 (12 ) ,1791-1802 More Information

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. ) Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, , 1 (11 ) ,1127-1140 More Information

Liu, Hang; Wang, Chenran; Yi, Fei; Yeo, Syn; Haas, Michael; Tang, Xin; Guan, Jun-Lin (2021. ) Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.Scientific reports, , 11 (1 ) ,23907 More Information

Turner, Kevin M; Yeo, Syn Kok; Holm, Tammy M; Shaughnessy, Elizabeth; Guan, Jun-Lin (2021. ) Heterogeneity within molecular subtypes of breast cancer.American journal of physiology. Cell physiology, , 321 (2 ) ,C343-C354 More Information

Wang, Chenran; Haas, Michael; Yeo, Syn Kok; Sebti, Salwa; Fernández, Álvaro F; Zou, Zhongju; Levine, Beth; Guan, Jun-Lin (2021. ) Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction.Autophagy, , 1-14 More Information

Wang, Chenran; Haas, Michael A; Yeo, Syn Kok; Paul, Ritama; Yang, Fuchun; Vallabhapurapu, Subrahmanya; Qi, Xiaoyang; Plas, David R; Guan, Jun-Lin (2021. ) Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.British journal of cancer, , 124 (10 ) ,1711-1723 More Information

Hao, Mingang; Yeo, Syn Kok; Guan, Jun-Lin (2021. ) Autophagy inhibition perturbs ERBB2 trafficking and abolishes tumorigenesis in ERBB2-driven breast cancer.Autophagy, , 17 (4 ) ,1059-1060 More Information

Yang, Yongguang; Leonard, Marissa; Luo, Zhenhua; Yeo, Syn; Bick, Gregory; Hao, Mingang; Cai, Chunmiao; Charif, Mahmoud; Wang, Jiang; Guan, Jun-Lin; Lower, Elyse E; Zhang, Xiaoting (2021. ) Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.Cell reports, , 34 (10 ) ,108822 More Information

Hao, Mingang; Yeo, Syn Kok; Turner, Kevin; Harold, Alexis; Yang, Yongguang; Zhang, Xiaoting; Guan, Jun-Lin (2021. ) Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles.Developmental cell, , 56 (3 ) ,341-355.e5 More Information

Manupati, Kanakaraju; Paul, Ritama; Hao, Mingang; Haas, Michael; Bian, Zhaoqun Christine; Holm, Tammy M; Guan, Jun-Lin; Yeo, Syn Kok (2022. ) Biglycan Promotes Cancer Stem Cell Properties, NF?B Signaling and Metastatic Potential in Breast Cancer Cells.Cancers, , 14 (2 ) , More Information

Contact Information

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267-0521
yeosn@ucmail.uc.edu