Syn Yeo

Syn Yeo

Instructor

Vontz Center

3445

COM Can Bio Guan Lab - 0521

Education

Ph.D., Cardiff University

BSc and MRes, Imperial College London

Postdoctoral training, University of Michigan

Research and Practice Interests

Current research projects examine the role of FIP200 and autophagy in breast cancer. General interest in intra-tumoral heterogeneity (non genetic, cell states, cancer stem cells) and strategies to sensitize breast cancers to immune checkpoint inhibitors.

Publications

Peer Reviewed Publications

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin (2018. ) Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.Autophagy, , 14 (7 ) ,1214-1225

Yeo, Syn Kok; Guan, Jun-Lin (2017. ) Breast Cancer: Multiple Subtypes within a Tumor?.Trends in cancer, , 3 (11 ) ,753-760

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin (2017. ) Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.The Journal of cell biology, , 216 (8 ) ,2581-2596

Yeo, Syn Kok; French, Rhiannon; Spada, Filomena; Clarkson, Richard (2017. ) Opposing roles of Nfkb2 gene products p100 and p52 in the regulation of breast cancer stem cells.Breast cancer research and treatment, , 162 (3 ) ,465-477

Yeo, Syn Kok; Guan, Jun-Lin (2016. ) Hierarchical heterogeneity in mammary tumors and its regulation by autophagy.Autophagy, , 12 (10 ) ,1960-1961

Yeo, Syn Kok; Wen, Jian; Chen, Song; Guan, Jun-Lin (2016. ) Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgf?/Smad Signaling.Cancer research, , 76 (11 ) ,3397-410

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin (2016. ) Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.Genes & development, , 30 (7 ) ,856-69

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. ) Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, , 212 (5 ) ,545-60

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin (2015. ) Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis.Breast cancer research and treatment, , 149 (3 ) ,619-29

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. ) Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, , 212 (7 ) ,879

Yeo, Syn Kok; Ali, Ahmed Y; Hayward, Olivia A; Turnham, Daniel; Jackson, Troy; Bowen, Ifor D; Clarkson, Richard (2016. ) ?-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines.Phytotherapy research : PTR, , 30 (3 ) ,418-25

Aydar, Ebru; Yeo, Syn; Djamgoz, Mustafa; Palmer, Christopher (2009. ) Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy.Cancer cell international, , 9 ,23

Wu, Hsin-Jung; Hao, Mingang; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication.Oncogene, ,

Okamoto, Takako; Yeo, Syn Kok; Hao, Mingang; Copley, Mary Rose; Haas, Michael A; Chen, Song; Guan, Jun-Lin (2020. ) FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function.Cancer research, , 80 (17 ) ,3580-3592

Yeo, Syn Kok; Wang, Chenran; Guan, Jun-Lin (2020. ) Role of FIP200 in inflammatory processes beyond its canonical autophagy function.Biochemical Society transactions, , 48 (4 ) ,1599-1607

Yeo, Syn Kok; Zhu, Xiaoting; Okamoto, Takako; Hao, Mingang; Wang, Cailian; Lu, Peixin; Lu, Long Jason; Guan, Jun-Lin (2020. ) Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer.eLife, , 9 ,

Yeo, Syn Kok; Guan, Jun-Lin (2020. ) Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function.Cell stress, , 4 (8 ) ,216-217

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) Correction to: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, , 22 (1 ) ,71

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, , 22 (1 ) ,59

Yang, Fuchun; Sun, Shaogang; Wang, Chenran; Haas, Michael; Yeo, Syn; Guan, Jun-Lin (2020. ) Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.British journal of cancer, , 122 (12 ) ,1791-1802

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. ) Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, , 1 (11 ) ,1127-1140