Li Zhang

Li Zhang

Associate Professor

Kettering Lab Complex

106

COM EH Biostat and Bioinfo Division - 0056

Professional Summary

Bioinformatics, particularly in the field of cancer genomics using deep learning and systems biology.

Education

PHD: University of North Carolina at Chapel Hill Chapel Hill, North carolina, USA, 1995 (Computational Structural Biology; Bioinformatics.)

Master of Science: Tsinghua University Beijing, China, 1988 (Biophysics)

BA: Wuhan University Wuhan, China, 1985 (Physics)

Research and Practice Interests

Research interests: Bioinformatics, particularly in the field of cancer genomics using deep learning and systems biology. Development of analytical pipelines that process genomic sequencing data to extract genetic, epi-genetic and transcriptomic information for cancer research. Current projects include: (1) Pattern recognition in massive genomic data using deep learning; (2) Data analysis and visualization of single cell RNAseq data; (3) Integrative genomic analysis of bladder cancers; (4) Analysis of DNA methylation data in epigenetic studies.

Publications

Peer Reviewed Publications

Fox, Melanie D; Xiao, Li; Zhang, Miao; Kamat, Ashish M; Siefker-Radtke, Arlene; Zhang, Li; Dinney, Colin P; Czerniak, Bogdan; Guo, Charles C (2017. ) Plasmacytoid Urothelial Carcinoma of the Urinary Bladder: A Clinicopathologic and Immunohistochemical Analysis of 49 Cases.American journal of clinical pathology, , 147 (5 ) ,500-506 More Information

Mobley, Aaron; Zhang, Shizhen; Bondaruk, Jolanta; Wang, Yan; Majewski, Tadeusz; Caraway, Nancy P; Huang, Li; Shoshan, Einav; Velazquez-Torres, Guermarie; Nitti, Giovanni; Lee, Sangkyou; Lee, June Goo; Fuentes-Mattei, Enrique; Willis, Daniel; Zhang, Li; Guo, Charles C; Yao, Hui; Baggerly, Keith; Lotan, Yair; Lerner, Seth P; Dinney, Colin; McConkey, David; Bar-Eli, Menashe; Czerniak, Bogdan (2017. ) Aurora Kinase A is a Biomarker for Bladder Cancer Detection and Contributes to its Aggressive Behavior.Scientific reports, , 7 ,40714 More Information

Dadhania, Vipulkumar; Zhang, Miao; Zhang, Li; Bondaruk, Jolanta; Majewski, Tadeusz; Siefker-Radtke, Arlene; Guo, Charles C; Dinney, Colin; Cogdell, David E; Zhang, Shizhen; Lee, Sangkyou; Lee, June G; Weinstein, John N; Baggerly, Keith; McConkey, David; Czerniak, Bogdan (2016. ) Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use.EBioMedicine, , 12 ,105-117 More Information

Guo, Charles Chuanhai; Dadhania, Vipulkumar; Zhang, Li; Majewski, Tadeusz; Bondaruk, Jolanta; Sykulski, Maciej; Wronowska, Weronika; Gambin, Anna; Wang, Yan; Zhang, Shizhen; Fuentes-Mattei, Enrique; Kamat, Ashish Madhav; Dinney, Colin; Siefker-Radtke, Arlene; Choi, Woonyoung; Baggerly, Keith A; McConkey, David; Weinstein, John N; Czerniak, Bogdan (2016. ) Gene Expression Profile of the Clinically Aggressive Micropapillary Variant of Bladder Cancer.European urology, , 70 (4 ) ,611-620 More Information

Tetzlaff, Michael T; Singh, Rajesh R; Seviour, Elena G; Curry, Jonathan L; Hudgens, Courtney W; Bell, Diana; Wimmer, Daniel A; Ning, Jing; Czerniak, Bogdan A; Zhang, Li; Davies, Michael A; Prieto, Victor G; Broaddus, Russell R; Ram, Prahlad; Luthra, Rajyalakshmi; Esmaeli, Bita (2016. ) Next-generation sequencing identifies high frequency of mutations in potentially clinically actionable genes in sebaceous carcinoma.The Journal of pathology, , 240 (1 ) ,84-95 More Information

Guo, Charles C; Bondaruk, Jolanta; Yao, Hui; Wang, Ziqiao; Zhang, Li; Lee, Sangkyou; Lee, June-Goo; Cogdell, David; Zhang, Miao; Yang, Guoliang; Dadhania, Vipulkumar; Choi, Woonyoung; Wei, Peng; Gao, Jianjun; Theodorescu, Dan; Logothetis, Christopher; Dinney, Colin; Kimmel, Marek; Weinstein, John N; McConkey, David J; Czerniak, Bogdan (2020. ) Assessment of Luminal and Basal Phenotypes in Bladder Cancer.Scientific reports, , 10 (1 ) ,9743 More Information

Guo, Charles C; Majewski, Tadeusz; Zhang, Li; Yao, Hui; Bondaruk, Jolanta; Wang, Yan; Zhang, Shizhen; Wang, Ziqiao; Lee, June Goo; Lee, Sangkyou; Cogdell, David; Zhang, Miao; Wei, Peng; Grossman, H Barton; Kamat, Ashish; Duplisea, Jonathan James; Ferguson, James Edward; Huang, He; Dadhania, Vipulkumar; Gao, Jianjun; Dinney, Colin; Weinstein, John N; Baggerly, Keith; McConkey, David; Czerniak, Bogdan (2019. ) Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder Cancer.Cell reports, , 27 (6 ) ,1781-1793.e4 More Information

Contact Information

zhang3l3@ucmail.uc.edu