Preclinical Imaging Core (PIC)

Lisa Lemen, PhD

The Core was established to provide non-invasive multimodal imaging capabilities optimized for rodent imaging to the UC research community. The facility specializes in micro-CT and micro-PET/SPECT for longitudinal research projects in small animal models, but also provides bioluminescence, fluorescence and planar x-ray imaging capabilites.  The Core actively supports research in cancer and other progressive diseases, and a variety of surgical and bioengineering projects. 

Location and Hours:
Vontz Center Rm 0330 (basement- restricted access - call lab 558-7930)
M-F  8:30am-5pm; or as arranged

Announcement  Sept 2018
Bioluminescence and Fluorescence imaging services are now available to PIs within the UC-COM LAMS mouse facilities – mice housed in the LAMS Vontz and MSB facilities remain behind the barrier for their imaging sessions and are returned to their original rooms. Please contact the lab for further information. 

  • PET/CT/SPECT imaging<br /> &nbsp;

    1. Standard Imaging services for small animals, with contrast agents and radiopharmaceuticals supplied as a pass-through charge
    a.Micro CT – in-vivo and ex-vivo imaging; specialized CT contrast agents 
    b.Micro SPECT with standard clinical tracers
    c.Micro PET with 18F-FDG
    d. co-registered modalities
    e. includes protocol-specific calibrations

    2.Advanced Imaging Services
    a.Respiratory or cardiac-gated CT
    b.Micro PET & SPECT with novel tracers


    $225 per hour

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  • Optical imaging (BLI, FLR) and x-ray<br /> &nbsp;

    1. Standard Imaging services for small animals, with agents supplied either by PI or as a pass-through charge
    a.Bioluminescence (BLI)  
    b.Fluorescence (FLR)
    c.visual (white-light)
    d. planar x-ray 
    e. co-registered modalities
    f. includes protocol-specific calibrations

    2. Advanced imaging services
    a.Mouse femur bone densitometry studies


    $125 per hour

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  • Investigator self processing&nbsp;<br /> &nbsp;

    Investigator use of image processing workstations and software.
    Basic instructions provided by lab personnel.  


    $50 per hour

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  • Image and Data post-processing<br /> &nbsp;

    Image post-processing by PIC personnel:
    1. basic tasks: data transfer; cropping; volumetrics; 
    2. advanced analysis: bone densitometry; pharmacokinetics; 


    $80 per hour

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  • Radiopharmaceuticals and specialized contrast agents



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  • Inveon PET/SPECT/CT

    Tri-modal micro-imaging system with LSO-based positron emission tomography (micro-PET), dual-head single photon emission computed tomography (micro-SPECT), and cone-beam computerized tomography (micro-CT) sub-systems.
    a) Bore size = 12 cm; max FOV = 10cm.

    Integrated Biovet monitoring system: respiratory, EKG, temperature control; heating pad on pallet
    Isoflurane anesthesia

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  • Bruker multi-spectral FX PRO

    Bioluminescence, fluorescence, x-ray, and optical imaging in small animals.

    a) 20 - 200 mm FOV (images up to 5 mice simultaneously)
    b) warm-air chamber with isoflurane anesthesia manifolds
    c) excitation filters: 390nm to 770nm in 20nm steps 
    d) emission filters: 535nm, 600 nm, 700nm, 750nm, 790nm, 830nm

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