Yoshinobu (Yoshi) Odaka, PhD

Yoshinobu (Yoshi) Odaka, PhD

Assistant Professor of Biology at UC Blue Ash College / Visiting Scholar at Cincinnati Children's Hospital Medical Center

Professional Summary

The dynamic transformation of cellular morphology during the locomotive process is a fascinating phenomenon. Endothelial cells, the essential component of blood vessels covering the innermost surface of the tubular structure, undergo such morphogenesis during development and certain pathological conditions including retinopathies, cancers, and arthritis. During the transformation process, endothelial cells become active in proliferation (an increase in the number of cells) and migration, the combination of which leads to the formation of new vessels (angiogenesis). My research interest is to investigate the molecular signals within the endothelial cell that govern the migratory aspect of angiogenesis, ultimately aiming to identify pharmacological means to intervene the unwanted angiogenesis in pathological conditions.

I also enjoy teaching Human Anatomy & Physiology (lecture and laboratory) as well as General Biology (lecture and laboratory). 

Education

Ph.D., Louisiana State University Health Shreveport (Biochemistry and Molecular Biology)

BS, Northland College (Double Major in Mathematics and Chemistry. Minor in Biology)

Research Support

Grant: #Student Research Funds. 2019 . Dean's Office, University of Cincinnati Blue Ash College. Investigating the role of protein kinase, mTOR (mechanistic target of rapamycin), in cellular locomotive process. $567.18 Completed

Grant: #Fellowship 2014 -2015 Cincinnati Children's Research Foundation. Notch-dependent regulation of pro-survival factor, VEGF-B, and pro-apoptotic factor, Wnt7b, in hyaloid associated macrophage for vascular regression Role:PI $10,000 Completed Type:Fellowship

Grant: #R25080 04-01-2019 -03-31-2020 University of Cincinnati Research Council. Pharmacological Investigation of Rapamycin on Pseudopodia Formation and Cell Mgration in Naegleria Gruberi. Role:PI $7,500.00 Active Type:Grant Level:University

Grant: #Research Launch Award 08-31-2019 -06-30-2020 UC Office of Research. $3,500.00 Active

Grant: #Student Research Funds. 2019 -2020 Dean's Office, University of Cincinnati Blue Ash College. Mechanism of drug resistance by Naegleria species. Role:PI $1962.60 Active Type:Grant

Publications

Peer Reviewed Publications

Nayak, Gowri*; Odaka, Yoshinobu*; Prasad, Vikram; Solano, Alyssa F; Yeo, Eun-Jin; Vemaraju, Shruti; Molkentin, Jeffery D; Trumpp, Andreas; Williams, Bart; Rao, Sujata; Lang, Richard A (2018. )Developmental vascular regression is regulated by a Wnt/b-catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death. * co-first authors.Development (Cambridge, England), ,145 (12 ),

Saijo, Fumito; Odaka, Yoshinobu; Mutoh, Mitsuhisa; Katayose, Yu; Tokumura, Hiromi (2018. )A novel technique of axillary vein puncture involving peripherally inserted central venous catheters for a small basilic vein.The journal of vascular access, ,19 (3 ),311-315

Todd, John R; Matsumoto, Tadahiko; Ueno, Ryohei; Murugaiyan, Jayaseelan; Britten, Allan; King, John W; Odaka, Yoshinobu; Oberle, Arnold; Weise, Christoph; Roesler, Uwe; Pore, R Scott (2018. )Medical phycology 2017.Medical mycology, ,56 (suppl_1 ),S188-S204

Sakabe, Masahide; Fan, Jieqing; Odaka, Yoshinobu; Liu, Ning; Hassan, Aishlin; Duan, Xin; Stump, Paige; Byerly, Luke; Donaldson, Megan; Hao, Jiukuan; Fruttiger, Marcus; Lu, Qing Richard; Zheng, Yi; Lang, Richard A; Xin, Mei (2017. )YAP/TAZ-CDC42 signaling regulates vascular tip cell migration.Proceedings of the National Academy of Sciences of the United States of America, ,114 (41 ),10918-10923

Muley, Ajit; Odaka, Yoshi; Lewkowich, Ian P; Vemaraju, Shruti; Yamaguchi, Terry P; Shawber, Carrie; Dickie, Belinda H; Lang, Richard A (2017. )Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature.PloS one, ,12 (8 ),e0181549

Shen, Tao; Shang, Chaowei; Zhou, Hongyu; Luo, Yan; Barzegar, Mansoureh; Odaka, Yoshinobu; Wu, Yang; Huang, Shile (2017. )Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A.Genes & cancer, ,8 (3-4 ),505-516

Odaka, Yoshinobu; Xu, Baoshan; Luo, Yan; Shen, Tao; Shang, Chaowei; Wu, Yang; Zhou, Hongyu; Huang, Shile (2014. )Dihydroartemisinin inhibits the mammalian target of rapamycin-mediated signaling pathways in tumor cells.Carcinogenesis, ,35 (1 ),192-200

Todd, John R; King, John W; Oberle, Arnold; Matsumoto, Tadahiko; Odaka, Yoshinobu; Fowler, Marjorie; Pore, R Scott; Shahan, Tracy Allan; Yin, Lijia; Sanusi, Irwan D (2012. )Protothecosis: report of a case with 20-year follow-up, and review of previously published cases.Medical mycology, ,50 (7 ),673-89

Chen, Wenxing; Liu, Lei; Luo, Yan; Odaka, Yoshinobu; Awate, Sanket; Zhou, Hongyu; Shen, Tao; Zheng, Shizhong; Lu, Yin; Huang, Shile (2012. )Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells.Cancer prevention research (Philadelphia, Pa.), ,5 (5 ),778-87

Han, Xiuzhen; Xu, Baoshan; Beevers, Christopher S; Odaka, Yoshinobu; Chen, Long; Liu, Lei; Luo, Yan; Zhou, Hongyu; Chen, Wenxing; Shen, Tao; Huang, Shile (2012. )Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells.Carcinogenesis, ,33 (4 ),868-75

Luo, Yan; Liu, Lei; Rogers, Donna; Su, Wei; Odaka, Yoshinobu; Zhou, Hongyu; Chen, Wenxing; Shen, Tao; Alexander, J Steven; Huang, Shile (2012. )Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression. Neoplasia (New York, N.Y.), ,14 (3 ),228-37

Li, Xiao-Lin; Zhang, Dongqing; Knight, David; Odaka, Yoshinobu; Glass, Jonathan; Mathis, J Michael; Zhang, Qian-Jin (2009. )Priming of immune responses against transporter associated with antigen processing (TAP)-deficient tumours: tumour direct priming.Immunology, ,128 (3 ),420-8

Li, Xiao-Lin; Liu, Yong-Yu; Knight, David; Odaka, Yoshinobu; Mathis, J Michael; Shi, Runhua; Glass, Jonathan; Zhang, Qian-Jin (2009. )Effect of B7.1 costimulation on T-cell based immunity against TAP-negative cancer can be facilitated by TAP1 expression.PloS one, ,4 (7 ),e6385

Siegele, Bradford; Cefalu, Christopher; Holm, Neal; Sun, Guang; Tubbs, Jesse; Meschonat, Carol; Odaka, Yoshinobu; DeBenedetti, Arrigo; Ghali, G E; Chu, Quyen; Mathis, J Michael; Li, Benjamin D L (2008. )eIF4E-targeted suicide gene therapy in a minimal residual mouse model for metastatic soft-tissue head and neck squamous cell carcinoma improves disease-free survival.The Journal of surgical research, ,148 (1 ),83-9

Stoff-Khalili, Mariam A; Rivera, Angel A; Nedeljkovic-Kurepa, Ana; DeBenedetti, Arrigo; Li, Xiao-Lin; Odaka, Yoshinobu; Podduturi, Jagat; Sibley, Don A; Siegal, Gene P; Stoff, Alexander; Young, Scott; Zhu, Zheng B; Curiel, David T; Mathis, J Michael (2008. )Cancer-specific targeting of a conditionally replicative adenovirus using mRNA translational control.Breast cancer research and treatment, ,108 (1 ),43-55

Mathis, J Michael; Williams, B Jill; Sibley, Don A; Carroll, Jennifer L; Li, Jie; Odaka, Yoshinobu; Barlow, Shayne; Nathan, Cherie-Ann O; Li, Benjamin D L; DeBenedetti, Arrigo (2006. )Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.The journal of gene medicine, ,8 (9 ),1105-20

Strat, Aurel; Gao, Lu; Utsuki, Tada; Cheng, Bing; Nuthalapaty, Sam; Mathis, J Mike; Odaka, Yoshinobu; Giordano, Tony (2006. )Specific and nontoxic silencing in mammalian cells with expressed long dsRNAs.Nucleic acids research, ,34 (13 ),3803-10

Mathis, J Michael; Bhatia, Shilpa; Khandelwal, Alok; Kovesdi, Imre; Lokitz, Stephen J; Odaka, Yoshi; Takalkar, Amol M; Terry, Tracee; Curiel, David T (2011. )Genetic incorporation of human metallothionein into the adenovirus protein IX for non-invasive SPECT imaging.PloS one, ,6 (2 ),e16792

Saijo F, Mutoh M, Tokumine J, Odaka Y, Hama H, Namima T, Shibahara M, Tokumura H (2019. )Late fracture of Groshong ports: A report of the three cases.J Vasc Access. , ,

Palaniyandi, S; Odaka, Y; Green, W; Abreo, F; Caldito, G; De Benedetti, A; Sunavala-Dossabhoy, G (2011. )Adenoviral delivery of Tousled kinase for the protection of salivary glands against ionizing radiation damage.Gene therapy, ,18 (3 ),275-82

Cromer, Walter; Jennings, Merilyn H; Odaka, Yoshinubo; Mathis, J Michael; Alexander, J Steven (2010. )Murine rVEGF164b, an inhibitory VEGF reduces VEGF-A-dependent endothelial proliferation and barrier dysfunction.Microcirculation (New York, N.Y. : 1994), ,17 (7 ),536-47

Odaka, Y; Mally, A; Elliott, L T; Meyers, S (2000. )Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8).Oncogene, ,19 (32 ),3584-97

Byrnes, Kerry; Li, Benjamin D L; Holm, Neal; Li, Jie; Odaka, Yoshi; De Benedetti, Arrigo; Nedeljkovic-Kurepa, A; Mathis, Michael; Chu, Quyen D (2007. )A novel suicide gene therapy targeting the overexpression of eukaryotic initiation factor 4E improves survival in a rat peritoneal carcinomatosis model. Surgery, ,142 (2 ),270-5

Nguyen, Minh-Thanh T; Vemaraju, Shruti; Nayak, Gowri; Odaka, Yoshinobu; Buhr, Ethan D; Alonzo, Nuria; Tran, Uyen; Batie, Matthew; Upton, Brian A; Darvas, Martin; Kozmik, Zbynek; Rao, Sujata; Hegde, Rashmi S; Iuvone, P Michael; Van Gelder, Russell N; Lang, Richard A (2019. )An opsin 5-dopamine pathway mediates light-dependent vascular development in the eye.Nature cell biology, ,21 (4 ),420-429

Luo J*, Odaka Y* (co-first author), Liu W, Zhang C, Shang C, Wu Y, Luo Y, Yang S, Dyck J, Guo X, Huang S (2019. )Dihydroartemisinin inhibits mTORC1 signaling by activating LKB1-AMPK-TSC network in tumor cells .Molecular Cancer (submitted), ,

Presentations

Invited Presentations

Odaka Y (session chair), Nayak G, Kelley K (undergraduate mentee), McLeod M (undergraduate mentee), Kumar DL, De Falco TJ, Kopan R, Lang R. (2017. )Notch loss-of-function leads to neovascularization in the hyaloid vasculature. Vascular Cell Biology, Gordon Research Seminar., Ventura, CA. Conference. .Level:International

Odaka Y (invited speaker), Nayak G, McLeod M (undergraduate mentee), Kopan R, Lang R. (2016. )The role of Notch in the hyaloid vascular regression. The International Symposium at the 120th Annual Meeting of the Japanese Ophthalmological Society., Sendai, Japan. Conference. .Level:International

Odaka Y (speaker), Nayak-Sarangdhar G, Dassanayake M (medical student mentee), Vemaraju S, Lang R. (2015. )Conditional knockout of Wnt co-receptors, Lrp5 and Lrp6, manifests persistent hyaloid vasculatures. Asia-Association for Research in Vision and Ophthalmology., Yokohama, Japan. Conference. .Level:International

Odaka Y (invited speaker), Mathis JM. (2009. )Non-invasive imaging of adenovirus vectors using a pIX-Metallothionein capsid fusion protein. South Central Society of Toxicology Annual Fall Meeting., Shreveport, LA. Professional Meeting. .Level:Regional

Odaka Y (invited speaker), Todd J. (2009. )Basic Biology of Prototheca. The 17th Congress of the International Society for Human and Animal Mycology., Tokyo, Japan. Conference. .Level:International

Honors and Awards

2014 -2015 Arnold W. Strauss Fellow , Cincinnati Children's Research Foundation.

2012 -2013 Carroll-Feist Cancer Research Fellow , Feist-Weiller Cancer Center, LSU Health Shreveport.

2013 First Place, Poster Presentation (post-proposal category), LSU Health Shreveport School of Graduate Studies

2011 Second Place, Poster Presentation (pre-proposal category), LSU Health Shreveport School of Graduate Studies

Post Graduate Training and Education

2013-2017 Research Fellow, Pediatric Ophthalmology Division, Cincinnati Children's Hospital Medical Center, ,

Keywords

Angiogenesis, Endothelial Cell, Target of Rapamycin (TOR), Notch, Cell Signaling, Cell Migration, Amoeba, Naegleria, Infectious Disease, Cancer, Drug Discovery, Biochemistry, Protein Structure.

Courses Taught

-BIOL-2001C ANAT PHYS I Level:Undergraduate

-BIOL-2002C ANAT PHYS II Level:Undergraduate

-BIOL-1081 BIOLOGY I Level:Undergraduate

-BIOL-1081L BIOLOGY I LAB Level:Undergraduate

-INTR-1020 INTRO TO SCI PROF Level:Undergraduate

Contact Information

Academic - University of Cincinnati Blue Ash College
9555 Plainfield Rd. Walters 136
Blue Ash  Ohio, 45236
Phone: (513) 745-5648
Fax: (513) 936-7113
yoshi.odaka@uc.edu