Gary Gudelsky

Gary A. Gudelsky

Professor

Medical Sciences Building

3212

Pharmacy Pharmaceutical Sciences - 0514

Gudelsky's Lab
231 Albert Sabin Way
Cincinnati, Ohio 45229

Professional Summary

The primary research projects being undertaken in the lab involve those that focus on the mechanisms and consequences of MDMA (Ecstasy)-induced serotonin neurotoxicity. With regard to MDMA neurotoxicity, it is our hypothesis that long term depletion of brain 5-HT occurs as a result of oxidative and/or bioenergetic stress induced by this drug of abuse. Moreover, such long term depletions of brain 5-HT are accompanied by functional consequences evident in disruptions of 5-HT neurotransmission. An additional area of interest is the neuropharmacology of second generation atypical antipsychotic agents. Current investigations focus on the differences in interactions of typical and atypical antipsychotics with glutamatergic neurotransmission.

Education

BA Chemistry, Kalamazoo College

PhD in Pharmacology, Michigan State University

Research and Practice Interests

Neuropharmacology of amphetamines

Research Support

Investigators:GA Gudelsky ,NIDA, Conditioned place preference to amphetamine following prenatal immune activation Role:Co-PI

Investigators:GA Gudelsky ,NIDA, Methamphetamine and cortiocstriatal glutamate Role:Co-PI

Investigators:GA Gudelsky ,NIDA, Determinants and Consequences of MDMA-Induced 5-HT Neurotoxicity Role:PI

Grant: #R01 DA007427 Investigators:Gudelsky, Gary 08-15-2006 -04-30-2012 National Institute on Drug Abuse Determinants and Consequences of MDMA Neurotoxicity Role:PI $1,514,953.00 Closed Level:Federal

Grant: #5-R01-DA-007427-11-A0-S0-E0 Investigators:Gudelsky, Gary 04-01-2000 -08-14-2006 National Institute on Drug Abuse Determinants and Consequences of MDMA Neurotoxicity Role:PI $1,265,196.00 Closed Level:Federal

Grant: #5-R44-DA-13300-04-A0-S0-E0 Investigators:Gudelsky, Gary 04-15-2002 -02-28-2005 National Institute on Drug Abuse Neurotoxin Discovery Platform Role:PI $198,022.00 Closed Level:Federal

Grant: #1-R44-DA-013300-01-A0-S0-E0 Investigators:Gudelsky, Gary 06-01-2000 -05-31-2001 National Institute on Drug Abuse Neurotoxin Discovery Platform - Drugs of Abuse Role:PI $32,453.00 Closed Level:Federal

Grant: #RIS-USA-T286-01-A0-S0-E0 Investigators:Gudelsky, Gary 12-01-2001 -11-30-2002 Janssen Pharmaceutica Research Foundation RIS-USA-T286 Effect of Antipsychotic Drugs on Acetylcholine Release Role:PI $21,468.00 Closed Level:Industry

Grant: #5-R01-DA-07427-06-A0-S0-E0 Investigators:Gudelsky, Gary 04-10-1997 -03-31-2000 National Institute on Drug Abuse Microdialysis Studies on MDMA-Induced Neurotoxicity Role:PI $443,354.00 Closed Level:Federal

Grant: #SRS 005803 Investigators:Gudelsky, Gary; Richtand, Neil 08-29-2008 -08-31-2011 Ortho-McNeil Janssen Scientific Affairs LLC Paliperidone and Glutamate in a Developmental Primary Prevention Model Role:Collaborator $160,076.00 Active Level:Industry

Grant: #1R21MH083192-01A1 Investigators:Benoit, Stephen; Gudelsky, Gary; Herman, James; Richtand, Neil; Stern, Javier 08-20-2008 -07-31-2011 National Institute of Mental Health Antipsychotics, Hypoglycemia, Glutamate and Cognition Role:Collaborator $386,100.00 Closed Level:Federal

Grant: #R21DA031876 Investigators:Benoit, Stephen; Gudelsky, Gary; Richtand, Neil 07-15-2012 -03-31-2014 National Institute on Drug Abuse Conditioned Place Preference to Amphetamine Following Prenatal Immune Activation Role:Collaborator $417,871.00 Active Level:Federal

Grant: #N2013-9 \ R01DA007606 Investigators:Gudelsky, Gary 07-01-2012 -04-30-2014 National Institute on Drug Abuse Methamphetamine Toxicity and Corticostriatal Glutamate Role:PI $37,158.00 Active Level:Federal

Grant: #08818-01-311642 / R21 DA031876 Investigators:Benoit, Stephen; Gudelsky, Gary 07-01-2013 -03-31-2014 National Institute on Drug Abuse Conditioned Place Preference to Amphetamine following Prenatal Immune Activation Role:PI $57,086.00 Awarded Level:Federal

Grant: #R15NS088384 Investigators:Gudelsky, Gary; Hao, Jiukuan 04-01-2015 -03-31-2018 National Institute of Neurological Disorders and Stroke Targeting the Blood-Brain Barrier in Ischemic Stroke Role:Collaborator $487,203.00 Awarded Level:Federal

Grant: #R01NS100947 Investigators:Gudelsky, Gary; Jiang, Jianxiong 12-01-2017 -11-30-2022 National Institute of Neurological Disorders and Stroke Inflammatory regulation of neurotrophin signaling in epileptogenesis Role:Collaborator $349,396.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Anneken, John H; Cunningham, Jacobi I; Collins, Stuart A; Yamamoto, Bryan K; Gudelsky, Gary A (2013. )MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, ,8 (1 ),58-65

Isom, Amanda M; Gudelsky, Gary A; Benoit, Stephen C; Richtand, Neil M (2013. )Antipsychotic medications, glutamate, and cell death: A hidden, but common medication side effect?.Medical hypotheses, ,80 (3 ),252-8

Huff, Courtney; Bhide, Nirmal; Schroering, Allen; Yamamoto, Bryan K; Gudelsky, Gary A (2013. )Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake.Brain research bulletin, ,91 ,52-7

Anneken, John H; Gudelsky, Gary A (2012. )MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus.Neuropharmacology, ,63 (6 ),1022-7

Roenker, Nicole L; Gudelsky, Gary A; Ahlbrand, Rebecca; Horn, Paul S; Richtand, Neil M (2012. )Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex.Neuropharmacology, ,63 (4 ),575-81

Schaefer, Tori L; Grace, Curtis E; Skelton, Matthew R; Graham, Devon L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2012. )Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats.ACS chemical neuroscience, ,3 (1 ),12-21

Darvesh, Altaf S; Carroll, Richard T; Geldenhuys, Werner J; Gudelsky, Gary A; Klein, Jochen; Meshul, Charles K; Van der Schyf, Cornelis J (2011. )In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery.Expert opinion on drug discovery, ,6 (2 ),109-127

Roenker, NL, Gudelsky, GA, Ahlbrand, R, Bronson, SL, Kern,JR, Waterman, H and Richtand, NM (2011. )Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801 .Neuroscience Letters, ,500 ,575-581

Yamamoto, Bryan K; Moszczynska, Anna; Gudelsky, Gary A (2010. )Amphetamine toxicities: classical and emerging mechanisms.Annals of the New York Academy of Sciences, ,1187 ,101-21

Schaefer, T L; Grace, C E; Gudelsky, G A; Vorhees, C V; Williams, M T (2010. )Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats.Stress (Amsterdam, Netherlands), ,13 (6 ),469-80

Pachmerhiwala, Rashida; Bhide, Nirmal; Straiko, Megan; Gudelsky, Gary A (2010. )Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.European journal of pharmacology, ,644 (1-3 ),67-72

Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2010. )(+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia.Synapse (New York, N.Y.), ,64 (10 ),773-85

Bhide, Nirmal S; Lipton, Jack W; Cunningham, Jacobi I; Yamamoto, Bryan K; Gudelsky, Gary A (2009. )Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain.Brain research, ,1286 ,32-41

Skelton, Matthew R; Able, Jessica A; Grace, Curtis E; Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. )(+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.Neuropharmacology, ,55 (7 ),1121-30

Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. )Effect of +-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats.Psychopharmacology, ,199 (4 ),637-50

Herring, Nicole R; Schaefer, Tori L; Tang, Peter H; Skelton, Matthew R; Lucot, James P; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. )Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats.BMC neuroscience, ,9 (2 ),49-59

Apparaju, Sandhya Kiran; Gudelsky, Gary A; Desai, Pankaj B (2008. )Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis.Cancer chemotherapy and pharmacology, ,61 (2 ),223-9

Gudelsky, GA and Yamamoto, BK (2008. )Actions of 3,4methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacology, Biochemistry and Behavior, ,90 ,198-207

Schaefer, TL, Skelton, MR, Herring, NR, Gudelsky, GA, Vorhees, CV, Williams, MT (2008. )Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. J. Neurochemistry, ,104 ,1674-1685

Straiko, MM, Gudelsky, GA and Coolen, LM (2007. )Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats .Behavioral Neuroscience, ,121 (3 ),58-593

Straiko, MM, Coolen, LM, Zemlan, FP and Gudelsky, GA (2007. )The effect of amphetamine analogs on cleaved microtubule associated protein-tau formation in the rat brain .Neuroscience, ,144 ,223-231

Schaefer, Tori L; Ehrman, Lisa A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2006. )Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat.Journal of neurochemistry, ,98 (5 ),1369-78

Able, Jessica A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2006. )3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory.Biological psychiatry, ,59 (12 ),1219-26

Nair, S G; Gudelsky, G A (2006. )Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex.Brain research bulletin, ,69 (4 ),382-7

Nair, Sunila G; Gudelsky, Gary A (2006. )3,4-Methylenedioxymethamphetamine enhances the release of acetylcholine in the prefrontal cortex and dorsal hippocampus of the rat.Psychopharmacology, ,184 (2 ),182-9

Darvesh, Altaf S; Gudelsky, Gary A (2005. )Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT.Brain research, ,1056 (2 ),168-75

Nair, SG and Gudelsky, GA (2005. )3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex .Synapse, ,58 ,229-235

Darvesh, A, Yamamoto, BK and Gudelsky, GA. (2005. )Evidence for the involvement of nitric oxide in 3,4-methyeledioxymethamphetamine-induced serotonin depletion in the rat brain .J. Pharmacol. Exp. Ther, ,312 ,694-701

Skelton, Matthew R; Blankenmeyer, Tracy L; Gudelsky, Gary A; Brown-Strittholt, Carrie A; Vorhees, Charles V; Williams, Michael T (2004. )Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats.Synapse (New York, N.Y.), ,54 (4 ),214-22

Nair, Sunila G; Gudelsky, Gary A (2004. )Protein kinase C inhibition differentially affects 3,4-methylenedioxymethamphetamine-induced dopamine release in the striatum and prefrontal cortex of the rat.Brain research, ,1013 (2 ),168-73

Williams, Michael T; Blankenmeyer, Tracy L; Schaefer, Tori L; Brown, Carrie A; Gudelsky, Gary A; Vorhees, Charles V (2003. )Long-term effects of neonatal methamphetamine exposure in rats on spatial learning in the Barnes maze and on cliff avoidance, corticosterone release, and neurotoxicity in adulthood. Brain research. Developmental brain research, ,147 (1-2 ),163-75

Darvesh, Altaf S; Gudelsky, Gary A (2003. )Activation of 5-HT2 receptors induces glycogenolysis in the rat brain. European journal of pharmacology, ,464 (2-3 ),135-40

Gudelsky, Gary A; Yamamoto, Bryan K (2003. )Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine. Methods in molecular medicine, ,79 ,55-73

Darvesh, Altaf S; Shankaran, Mahalakshmi; Gudelsky, Gary A (2002. )3,4-Methylenedioxymethamphetamine produces glycogenolysis and increases the extracellular concentration of glucose in the rat brain. The Journal of pharmacology and experimental therapeutics, ,301 (1 ),138-44

Wallace, T L; Vorhees, C V; Gudelsky, G A (2001. )Effects of lubeluzole on the methamphetamine-induced increase in extracellular glutamate and the long-term depletion of striatal dopamine.Synapse (New York, N.Y.), ,40 (2 ),95-101

Shankaran, M; Yamamoto, B K; Gudelsky, G A (2001. )Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.Synapse (New York, N.Y.), ,40 (1 ),55-64

Huff, Courtney L; Morano, Rachel L; Herman, James P; Yamamoto, Bryan K; Gudelsky, Gary A (2016. )MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.Neurotoxicology, ,57 ,282-290

Collins, Stuart A; Huff, Courtney; Chiaia, Nicolas; Gudelsky, Gary A; Yamamoto, Bryan K (2016. )3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling.Journal of neurochemistry, ,136 (5 ),1074-84

Collins, Stuart A; Gudelsky, Gary A; Yamamoto, Bryan K (2015. )MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors.European journal of pharmacology, ,761 ,95-100

Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B (2015. )Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.Molecular cancer therapeutics, ,14 (4 ),857-64

Krishan, Mansi; Gudelsky, Gary A; Desai, Pankaj B; Genter, Mary Beth (2014. )Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain.Drug delivery, ,21 (1 ),8-16

Weber, Georg F; Johnson, Bethann N; Yamamoto, Bryan K; Gudelsky, Gary A (2014. )Effects of stress and MDMA on hippocampal gene expression.BioMed research international, ,2014 ,141396

Dave, Nimita; Gudelsky, Gary A; Desai, Pankaj B (2013. )The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.Cancer chemotherapy and pharmacology, ,72 (2 ),349-57

Grace, Curtis E; Schaefer, Tori L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin.Neurotoxicology and teratology, ,32 (3 ),356-61

Grace, Curtis E; Schaefer, Tori L; Herring, Nicole R; Graham, Devon L; Skelton, Matthew R; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice.Neurotoxicology and teratology, ,32 (3 ),346-55

Gudelsky, Gary A; Yamamoto, Bryan K (2008. )Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons.Pharmacology, biochemistry, and behavior, ,90 (2 ),198-207

Schaefer, Tori L; Skelton, Matthew R; Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. )Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment.Journal of neurochemistry, ,104 (6 ),1674-85

Straiko, Megan M W; Gudelsky, Gary A; Coolen, Lique M (2007. )Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.Behavioral neuroscience, ,121 (3 ),586-93

Straiko, M M W; Coolen, L M; Zemlan, F P; Gudelsky, G A (2007. )The effect of amphetamine analogs on cleaved microtubule-associated protein-tau formation in the rat brain.Neuroscience, ,144 (1 ),223-31

Nair, Sunila G; Gudelsky, Gary A (2005. )3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex.Synapse (New York, N.Y.), ,58 (4 ),229-35

Williams, Michael T; Schaefer, Tori L; Ehrman, Lisa A; Able, Jessica A; Gudelsky, Gary A; Sah, Renu; Vorhees, Charles V (2005. )3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity.Brain research, ,1039 (1-2 ),97-107

Darvesh, Altaf S; Yamamoto, Bryan K; Gudelsky, Gary A (2005. )Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.The Journal of pharmacology and experimental therapeutics, ,312 (2 ),694-701

Nair, Sunila G; Gudelsky, Gary A (2004. )Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat.Synapse (New York, N.Y.), ,53 (4 ),202-7

Darvesh, Altaf S; Gudelsky, Gary A The relationship between hyperthermia and glycogenolysis in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats.Neurotoxicology and teratology, ,26 (4 ),571-7

Wallace, T L; Vorhees, C V; Zemlan, F P; Gudelsky, G A (2003. )Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain. Neuroscience, ,116 (4 ),1063-8

Wallace, T L; Gudelsky, G A; Vorhees, C V (2001. )Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine. Psychopharmacology, ,153 (3 ),321-6

Wallace, T L; Gudelsky, G A; Vorhees, C V (2001. )Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat.Synapse (New York, N.Y.), ,39 (1 ),1-7

Shankaran, M; Yamamoto, B K; Gudelsky, G A (1999. )Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. European journal of pharmacology, ,385 (2-3 ),103-10

Shankaran, M; Gudelsky, G A (1999. )A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration. Psychopharmacology, ,147 (1 ),66-72

Wallace, T L; Gudelsky, G A; Vorhees, C V (1999. )Methamphetamine-induced neurotoxicity alters locomotor activity, stereotypic behavior, and stimulated dopamine release in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience, ,19 (20 ),9141-8

Shankaran, M; Yamamoto, B K; Gudelsky, G A (1999. )Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum. Journal of neurochemistry, ,72 (6 ),2516-22

Shankaran, M; Gudelsky, G A (1998. )Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin. Pharmacology, biochemistry, and behavior, ,61 (4 ),361-6

Gudelsky, G A (1996. )Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin.Journal of neural transmission (Vienna, Austria : 1996), ,103 (12 ),1397-404

Gudelsky, G A; Nash, J F (1996. )Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. Journal of neurochemistry, ,66 (1 ),243-9

Gudelsky, G A; Nwajei, E E; Defife, K; Nash, J F (1992. )Effects of amfonelic acid and GBR 12909 on the haloperidol- and clozapine-induced activation of dopamine neurons. Psychopharmacology bulletin, ,28 (3 ),275-9

Nash, J F; Meltzer, H Y; Gudelsky, G A (1988. )Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. European journal of pharmacology, ,151 (3 ),463-9

Pitzer, Emily M; Sugimoto, Chiho; Gudelsky, Gary A; Huff Adams, Courtney L; Williams, Michael T; Vorhees, Charles V (2019. )Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits.Toxicological sciences : an official journal of the Society of Toxicology, ,169 (2 ),511-523

Arora, Priyanka; Adams, Courtney Huff; Gudelsky, Gary; DasGupta, Biplab; Desai, Pankaj B (2019. )Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats.Cancer chemotherapy and pharmacology, ,83 (1 ),81-89

Roenker, Nicole L; Gudelsky, Gary; Ahlbrand, Rebecca; Bronson, Stefanie L; Kern, Joseph R; Waterman, Heather; Richtand, Neil M (2011. )Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801.Neuroscience letters, ,500 (3 ),167-71

Hui, Anna S; Striet, Justin B; Gudelsky, Gary; Soukhova, Galia K; Gozal, Evelyne; Beitner-Johnson, Dana; Guo, Shang-Z; Sachleben, Leroy R; Haycock, John W; Gozal, David; Czyzyk-Krzeska, Maria F (2003. )Regulation of catecholamines by sustained and intermittent hypoxia in neuroendocrine cells and sympathetic neurons.Hypertension (Dallas, Tex. : 1979), ,42 (6 ),1130-6

Harold, C; Wallace, T; Friedman, R; Gudelsky, G; Yamamoto, B (2000. )Methamphetamine selectively alters brain glutathione.European journal of pharmacology, ,400 (1 ),99-102

Burrows, K B; Gudelsky, G; Yamamoto, B K (2000. )Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration.European journal of pharmacology, ,398 (1 ),11-8

Ackerman, G E; MacDonald, P C; Gudelsky, G; Mendelson, C R; Simpson, E R (1981. )Potentiation of epinephrine-induced lipolysis by catechol estrogens and their methoxy derivatives.Endocrinology, ,109 (6 ),2084-8

Keywords

Dopamine,Clozapine,Serotonin,Haloperidol,Pentazocine,Pcp Receptor,Drug Receptor,Microdialysis,Schizophrenia,Laboratory Rat,Neurochemistry,Corpus Striatum,Methamphetamine,Neurotransmitter,Neuropharmacology,Antipsychotic Agent,Stereotaxic Technique

MDMA

Contact Information

Academic - Phone: 513-558-5735
Gary.Gudelsky@uc.edu

Research - Gudelsky's Lab
231 Albert Sabin Way
CincinnatiĀ  Ohio, 45229