Thomas B Leemhuis , PhD

Director of Cellular Therapies, Hoxworth Blood Center

Associate Professor of Pediatrics, University of Cincinnati

Provide technical and administrative leadership for 8-person team responsible for processing all bone marrow, peripheral blood apheresis products, and umbilical cord bloods for transplantation at either UC Health, Cincinnati Childrens’Hospital Medical Center, Jewish Hospital, or Akron Children’s Hospital.

Provide late stage process development, regulatory submission assistance, and c-GMP compliant production of cell therapy products for phase I/II clinical trials at local area hospitals. Responsible for all staff training, SOP and batch record development, and coordination of all production-related activities, including quality control testing, materials management and facility maintenance.

Define and maintain Quality Management Plan for the Cellular Therapies Division. Maintain FACT and AABB accreditations for Cellular Therapies Division.

IND sponsor for one investigational agent (CD34+ selected peripheral blood progenitor cells) being tested for safety and efficacy in two phase 2 clinical trial protocols at CCHMC; under two separate INDs with FDA.

Designed and maintain fully validated class 10,000 clean room facility. Author of all facility maintenance, cleaning and environmental monitoring procedures.  

Doctoral Degree: Indiana University School of Medicine Indianapolis, IN, 1993 (Experimental Hematology)

Master's Degree: Purdue University West Lafayette, IN , 1985 (Immunology)

Bachelor's Degree: Indiana University Indianapolis, IN, 1978 (Microbiology)

Investigators:Leemhuis, Thomas 09-01-2002 -06-30-2003 Cincinnati Children's Hospital Medical Center CGMP Cell Manipulations Lab Agreement Role:PI $74,035.60 Closed Level:Private Non-Profit

Peer Reviewed Publications

Schnizlein-Bick, C T; Sherman, M R; Boggs, D L; Leemhuis, T B; Fife, K H (1992. ) Incidence of HIV infection in monocyte subpopulations characterized by CD4 and HLA-DR surface density. AIDS (London, England), , 6 (2 ) ,151-6

Brandt, J; Briddell, R A; Srour, E F; Leemhuis, T B; Hoffman, R (1992. ) Role of c-kit ligand in the expansion of human hematopoietic progenitor cells. Blood, , 79 (3 ) ,634-41

Briddell, R A; Brandt, J E; Leemhuis, T B; Hoffman, R (1992. ) Role of cytokines in sustaining long-term human megakaryocytopoiesis in vitro. Blood, , 79 (2 ) ,332-7

Cellular Therapy ,Anatomy(MeSH A),Chemicals and Drugs(MeSH D),Analytical, Diagnostic and Therapeutic Techniques and Equipment(MeSH E),Cells(MeSH A11),Hemic and Immune Systems(MeSH A15),Immunologic and Biological Factors(MeSH D24),Therapeutics(MeSH E02),Equipment and Supplies(MeSH E07)

Hoxworth 5015
3130 Highland Avenue
Cincinnati  Ohio, 45267
Phone: 513-558-1553
thomas.leemhuis@uc.edu