Nalinikanth Kotagiri

Research in my laboratory will aim to develop innovative and advanced solutions to treat human disease through a highly multidisciplinary approach. We are interested in manufacturing novel molecular probes using small molecules as well as nanoparticulate systems for imaging disease processes and therapeutic applications. Particular emphasis is on activation of therapeutic events in targeted tissues with a high degree of spatiotemporal precision and control using photons and ionizing radiation. We involve the entire bench-bedside spectrum of chemical biology research, from bio-chemical probe synthesis to their evaluation in cell systems and animal disease models, including development of microfluidic and lab-on-chip approaches for optimization. The eventual goal is to bring together diverse yet complimentary technologies to develop useful technology platforms for basic science and clinically translatable work.

M.B,B.S: Andhra Medical College Visakhapatnam, India, 2000 (General Medicine)

Ph.D: University of Arkansas Fayetteville, AR USA, 2011 (Cell & Molecular Biology)

2004 -2011 Graduate Research Assistant, University of Arkansas, Fayetteville, AR USA

2011 -2015 Postdoctoral Research Associate, Washington University School of Medicine, St. Louis, MO USA

2015 -2016 Instructor, Washington University School of Medicine, St. Louis, MO USA

2016 -2022 Assistant Professor, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH USA

2022 -To Present Associate Professor, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH USA

Grant: #URS Strategic Collaborative Grants AY2017-2018 Investigators:Kotagiri, Nalinikanth, Connick, William, Spitz, Henry 08-01-2017 -01-31-2018 UC Role:PI $90,000.00 Active

Grant: #WU-18-188 / U54 CA199092 Investigators:Kotagiri, Nalinikanth 08-01-2017 -07-31-2018 National Cancer Institute Role:PI $50,000.00

Grant: #AHA 18IPA34170157 Investigators:Hassett, Daniel; Kotagiri, Nalinikanth; O 07-01-2018 -06-30-2020 American Heart Association - National Chapter Accurate and early noninvasive imaging of bacterial endocarditis Role:PI $200,000.00 Active

Grant: #W81XWH-18-1-0609 Investigators:Ho, Shuk Mei; Kotagiri, Nalinikanth; Mahoney, Mary 09-01-2018 -08-31-2021 Department of the Army Radionuclide activated precision phototherapy of metastatic breast cancer Role:PI $601,303.00 Awarded Level:Federal

Grant: #W81XWH1910125 Investigators:Hassett, Daniel; Kotagiri, Nalinikanth 05-01-2019 -10-31-2020 Department of Defense Site-specific detection of latent tuberculosis through nuclear imaging Role:PI $267,593.00 Awarded Level:Federal

Grant: #GIVE HOPE Pancreatic Cancer Pilot Grant Investigators:Nalinikanth Kotagiri, Daniel Hassett, Zhongyun Dong 09-03-2019 -08-30-2020 University of Cincinnati Cancer Institute Microbial Anti-Pancreatic Cancer Therapy Targeting DNA Polymerase Role:PI $75,000 Active Type:Grant Level:University

Grant: #R21GM137321 Investigators:Hassett, Daniel; Kotagiri, Nalinikanth 07-01-2020 -06-30-2022 National Institute of General Medical Sciences A Synthetic Approach for Bacterial-Mammalian Cell Binding Role:PI $245,041.00 Awarded Level:Federal

Grant: #R25092 Investigators:Kotagiri, Nalinikanth 03-01-2021 -03-31-2023 UC's URC Faculty Scholars Program URC-Faculty Scholars Res Awd-Kotagiri, Nalinikanth Role:PI $25,000.00 Active Level:Internal UC

Grant: #ME200246 Investigators:Abdelmalek, Zalfa; Hassett, Daniel; Kotagiri, Nalinikanth 06-01-2021 -05-31-2024 Department of the Army Medical Research Acquisition Activity Engineering Skin Microbiome to Generate Natural Sunscreens for Prevention of Melanoma Role:PI 0.00 Hold Level:Federal

Grant: #R01HL168588 Investigators:Borchers, Michael; Kotagiri, Nalinikanth; McCormack, Francis; Weiss, Alison; Xie, Changchun 07-01-2023 -06-30-2028 National Heart, Lung and Blood Institute Siderophore based molecular imaging of pulmonary infections Role:PI 678865.00 Awarded Level:Federal

Grant: #24TPA1303687 Investigators:Kotagiri, Nalinikanth; Sadayappan, Sakthivel; Sertorio, Mathieu 07-01-2024 -06-30-2027 American Heart Association - National Chapter Engineered probiotic to mitigate heart disease associated inflammation Role:PI 300000.00

Grant: #R01CA279962 JIT Investigators:Desai, Pankaj; Faber, Ed; Kotagiri, Nalinikanth; Sertorio, Mathieu; Xie, Changchun 12-01-2023 -11-30-2028 National Cancer Institute Genetically-encoded molecular imaging of genome-edited immune cells Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Kotagiri, Nalinikanth; Sakon, Joshua; Han, Haewook; Zharov, Vladimir P; Kim, Jin-Woo (2016. ) Fluorescent ampicillin analogues as multifunctional disguising agents against opsonization.Nanoscale, , 8 (25 ) ,12658-67

Link to article

Kotagiri, Nalinikanth; Cooper, Matthew L.; Rettig, Michael; Egbulefu, Christopher; Prior, Julie; Cui, Grace; Karmakar, Partha; Zhou, Mingzhou; Yang, Xiaoxia; Sudlow, Gail; Marsala, Lynne; Chanswangphuwana, Chantiya; Lu, Lan; Habimana-Griffin, LeMoyne; Shokeen, Monica; Xu, Xinming; Weilbaecher, Katherine; Tomasson, Michael; Lanza, Gregory; DiPersio, John F.; Achilefu, Samuel (2018. ) Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer .Nature Communications, , 9 (1 ) ,275

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Kotagiri, Nalinikanth; Sudlow, Gail P; Akers, Walter J; Achilefu, Samuel (2015. ) Breaking the depth dependency of phototherapy with Cerenkov radiation and low-radiance-responsive nanophotosensitizers.Nature nanotechnology, , 10 (4 ) ,370-9

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Kotagiri, Nalinikanth; Li, Zhenyu; Xu, Xiaoxiao; Mondal, Suman; Nehorai, Arye; Achilefu, Samuel (2014. ) Antibody quantum dot conjugates developed via copper-free click chemistry for rapid analysis of biological samples using a microfluidic microsphere array system.Bioconjugate chemistry, , 25 (7 ) ,1272-81

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Kotagiri, Nalinikanth; Kim, Jin-Woo (2014. ) Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution.International journal of nanomedicine, , 9 Suppl 1 ,85-105

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Kotagiri, Nalinikanth; Niedzwiedzki, Dariusz M; Ohara, Kohtaro; Achilefu, Samuel (2013. ) Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation.Angewandte Chemie (International ed. in English), , 52 (30 ) ,7756-60

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Kotagiri, Nalinikanth; Lee, Ju Seok; Kim, Jin-Woo (2013. ) Selective pathogen targeting and macrophage evading carbon nanotubes through dextran sulfate coating and PEGylation for photothermal theranostics. Journal of biomedical nanotechnology, , 9 (6 ) ,1008-16

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Xu, Xiaoxiao; Sarder, Pinaki; Kotagiri, Nalinikanth; Achilefu, Samuel; Nehorai, Arye (2013. ) Performance analysis and design of position-encoded microsphere arrays using the Ziv-Zakai bound.IEEE transactions on nanobioscience, , 12 (1 ) ,29-40

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Kotagiri, Nalinikanth; Kim, Jin-Woo (2010. ) Carbon nanotubes fed on "carbs": coating of single-walled carbon nanotubes by dextran sulfate.Macromolecular bioscience, , 10 (3 ) ,231-8

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Kim, Jin-Woo; Shashkov, Evgeny V; Galanzha, Ekaterina I; Kotagiri, Nalinikanth; Zharov, Vladimir P (2007. ) Photothermal antimicrobial nanotherapy and nanodiagnostics with self-assembling carbon nanotube clusters.Lasers in surgery and medicine, , 39 (7 ) ,622-34

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Kim, Jin-Woo; Kotagiri, Nalinikanth; Kim, Jeong-Hwan; Deaton, Russell (2006. ) In situ fluorescence microscopy visualization and characterization of nanometer-scale carbon nanotubes labeled with 1-pyrenebutanoic acid, succinimidyl ester .Appl. Phys. Lett., , 88 ,213110

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Kotagiri, Nalinikanth; Laforest, Richard; Achilefu, Samuel (2018. ) Reply to 'Is Cherenkov luminescence bright enough for photodynamic therapy?'.Nature nanotechnology, , 13 (5 ) ,354-355 More Information

Siddiqui, Nabil A; Houson, Hailey A; Kamble, Nitin S; Blanco, Jose R; O'Donnell, Robert E; Hassett, Daniel J; Lapi, Suzanne E; Kotagiri, Nalinikanth (2021. ) Leveraging copper import by yersiniabactin siderophore system for targeted PET imaging of bacteria.JCI insight, , 6 (10 ) ,

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Bogue, Amy L; Panmanee, Warunya; McDaniel, Cameron T; Mortensen, Joel E; Kamau, Edwin; Actis, Luis A; Johannigman, Jay A; Schurr, Michael J; Satish, Latha; Kotagiri, Nalinikanth; Hassett, Daniel J (2021. ) AB569, a non-toxic combination of acidified nitrite and EDTA, is effective at killing the notorious Iraq/Afghanistan combat wound pathogens, multi-drug resistant Acinetobacter baumannii and Acinetobacter spp.PloS one, , 16 (3 ) ,e0247513 More Information

Lane, Daniel D; Black, Kvar C L; Raliya, Ramesh; Reed, Nathan; Kotagiri, Nalinikanth; Gilson, Rebecca; Tang, Rui; Biswas, Pratim; Achilefu, Samuel (2020. ) Effects of core titanium crystal dimension and crystal phase on ROS generation and tumour accumulation of transferrin coated titanium dioxide nanoaggregates.RSC advances, , 10 (40 ) ,23759-23766 More Information

Kotagiri, Nalinikanth; Cooper, Matthew L; Rettig, Michael; Egbulefu, Christopher; Prior, Julie; Cui, Grace; Karmakar, Partha; Zhou, Mingzhou; Yang, Xiaoxia; Sudlow, Gail; Marsala, Lynne; Chanswangphuwana, Chantiya; Lu, Lan; Habimana-Griffin, LeMoyne; Shokeen, Monica; Xu, Xinming; Weilbaecher, Katherine; Tomasson, Michael; Lanza, Gregory; DiPersio, John F; Achilefu, Samuel (2018. ) Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer.Nature communications, , 9 (1 ) ,275 More Information

Hassett, Daniel J; Kovall, Rhett A; Schurr, Michael J; Kotagiri, Nalinikanth; Kumari, Harshita; Satish, Latha (2021. ) The Bactericidal Tandem Drug, AB569: How to Eradicate Antibiotic-Resistant Biofilm Pseudomonas aeruginosa in Multiple Disease Settings Including Cystic Fibrosis, Burns/Wounds and Urinary Tract Infections.Frontiers in microbiology, , 12 ,639362 More Information

Thomas, Shindu C; Madaan, Tushar; Kamble, Nitin S; Siddiqui, Nabil A; Pauletti, Giovanni M; Kotagiri, Nalinikanth (2021. ) Engineered Bacteria Enhance Immunotherapy and Targeted Therapy through Stromal Remodeling of Tumors.Advanced healthcare materials, , e2101487 More Information

Singaravelu, Indulekha; Spitz, Henry; Mahoney, Mary; Dong, Zhongyun; Kotagiri, Nalinikanth (2021. ) Anti-Androgen Therapy Radiosensitizes Androgen Receptor Positive Cancers to F-18 Fluorodeoxyglucose.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , More Information

Thomas, Shindu; Kim, Jin-Woo; Pauletti, Giovanni; Hassett, Daniel; Kotagiri, Nalinikanth (2022. ) Exosomes: Biological Pharmaceutical Nanovectors for Theranostics.Front. Bioeng. Biotechnol., , 9 ,

Link

Thomas, Shindu C; Kim, Jin-Woo; Pauletti, Giovanni M; Hassett, Daniel J; Kotagiri, Nalinikanth (2021. ) Exosomes: Biological Pharmaceutical Nanovectors for Theranostics.Frontiers in bioengineering and biotechnology, , 9 ,808614 More Information

Siddiqui, Nabil A; Ventrola, Alec J; Hartman, Alexandra R; Konare, Tohonne; Kamble, Nitin S; Thomas, Shindu C; Madaan, Tushar; Kharofa, Jordan; Sertorio, Mathieu G; Kotagiri, Nalinikanth (2023. ) An Engineered Probiotic Platform for Cancer Epitope-Independent Targeted Radionuclide Therapy of Solid Tumors.Advanced healthcare materials, , e2202870 More Information

2011 Best Poster Award, IEEE International Conference on Biotronics

2012 Travel Award, National Cancer Institute Imaging Camp

2013 Travel Award, World Molecular Imaging Congress

2017 Early career investigator travel award, Radiation Research Society Annual Meeting

2018 BCRP Breakthrough Award, Department of Defense

2018 Innovative Project Award, American Heart Association

2019 Dan Adams Thinking Outside the Box Award, Bugher-American Heart Association

2019 PRMRP Discovery Award, Department of Defense

2021 Faculty Scholars Award University of Cincinnati

2021 MRP Idea Award Department of Defense

Bioengineering microbiome, Photopharmacology, Experimental Therapeutics, Molecular Imaging

Medical Sciences Building 3109B
Phone: (513) 558-6161

Research - Kotagiri's Lab
231 Albert Sabin Way
Cincinnati  Ohio, 45229
Phone: 513-558-3064
https://pharmacy.uc.edu/research/kotagiri_laboratory