Sohaib A Khan , PhD

Sohaib Khan, Professor of Cancer and Cell Biology, completed his undergraduate and graduate training at Aligarh University in India and was a postdoctoral fellow at the Tal Institute in Bombay. He was a research scientist at the Roswell Park Memorial Institute and at Case Western Reserve University. He joined the University of Cincinnati as a faculty member in 1982. The Khan laboratory is studying the mechanism involved in estrogen-induced cell differentiation and apoptosis of normal and malignant target tissues such as breast and uterus. They have shown that estrogen functions through its receptor by activating early response protooncogenes. The group utilizes molecular biological, yeast genetic and transgenic technologies to decipher the mechanism of estrogen receptor action with the hope of understanding breast and endometrial cancer.

Bachelor's Degree: Aligarh University 1961 (Chemistry, Biology )

Master's Degree: Aligarh University 1969 (Biochemistry )

Doctoral Degree: Aligarh University 1974 (Biochemistry )

Post-Doctoral Degree: Tata Institute of Fundamental Research 1975 (Molecular Biology)

1) To understand the mechanism by which cells control the level of cholesterol in the body, we are studying the transcriptional regulation of the rat HMG-CoA reductase (HMGR) gene. HMGR is the rate limiting enzyme of cellular cholesterol synthesis. 2) Inthe second project, we are studying the role insulin plays in the regulation of glycogen phosphorylase gene. 3) In the other project underway, we are studying the role oncogenes play in cell differentiation.

1975 -1979 Cancer Research Scientist, Roswell Park Memorial Institute, Buffalo, NY

1979 -1980 Senior Research Associate, Case Western Reserve University, Cleveland, OH

1982 -1986 Assistant Professor, Department of Cell Biology, University of Cincinnati, Cincinnati

1987 -2000 Associate Professor, Department of Cell Biology, University of Cincinnati, Cincinnati, OH

1987 -1987 Advance Course in Mammalian Genetics (Johns Hopkins/Jackson Labs),

1998 -To Present Director, NCI Training Program in Cancer,

2000 -To Present Professor, Department of Cell & Cancer Biology, University of Cincinnati, Cincinnati, OH

2005 -To Present Hormonal Carcinogenesis Program Leader, Cincinnati Cancer Consortium,

2008 -To Present Vice Chair, Department of Cancer & Cell Biology, UC College of Medicine,

Grant: #2T32 CA059268-11 07-01-2006 -06-30-2011 NIH/NCI Regulation of Cellular Growth and Differentiation Role:PI Active

Investigators:(PI: Susan Waltz) 09-01-2006 -08-31-2011 Training Program in Cancer Therapeutics Role:Co-PI Active

Investigators:Stuart Handwerger, PI 07-01-1999 -06-30-2009 National Institutes of Health Training in Developmental & Perinatal Endocrinology Role:Co-PI Completed Type:Grant

Grant: #2 T32 CA059268-11A2 Investigators:Khan, Sohaib 08-22-2006 -04-30-2013 National Cancer Institute Regulation of Cellular Growth and Differentiation Role:PI $1,393,404.00 Active Level:Federal

Grant: #1-R13-DK-066609-01-A0-S0-E0 Investigators:Khan, Sohaib 02-20-2004 -02-28-2005 National Inst of Diabetes and Digestive and Kidney Disease Nuclear Receptors and Endocrine Disorders Role:PI $19,000.00 Closed Level:Federal

Grant: #5-R01-CA-72039 Investigators:Khan, Sohaib 04-01-2002 -03-31-2008 National Cancer Institute Estrogen Receptor Variants and Breast Cancer Role:PI $1,370,528.00 Closed Level:Federal

Grant: #CN-159-03-A0-S0-E0 Investigators:Khan, Sohaib 07-01-1996 -06-30-2000 American Cancer Society - National Chapter Mechanism of Estrogen-Induced Uterine Cell Proliferation Role:PI $300,000.00 Closed Level:Private Non-Profit

Grant: #5-R01-CA-72039-04-A0-S0-E0 Investigators:Khan, Sohaib 09-01-1996 -06-30-2001 National Cancer Institute Estrogen Receptor Variants and Breast Cancer Role:PI $674,267.00 Closed Level:Federal

Grant: #5-R01-HD-29773-08-A0-S0-E0 Investigators:Khan, Sohaib 04-01-1999 -03-31-2005 National Institute of Child Health and Human Development Growth Factor Control of Apoptosis during Placentation Role:PI $1,094,247.00 Closed Level:Federal

Grant: #1-S10-RR-12924-01-A1-S0-E0 Investigators:Khan, Sohaib 02-15-1999 -02-14-2000 National Center for Research Resources BIAcore 2000 System Role:PI $238,000.00 Closed Level:Federal

Grant: #5-T32-CA-59268-10-A0-S0-E0 Investigators:Khan, Sohaib 07-01-1999 -04-30-2005 National Cancer Institute Regulation of Cellular Growth and Differentiation Role:PI $1,124,881.00 Closed Level:Federal

Grant: #DAMD17-00-1-0057-03-A0-S0-E0 Investigators:Khan, Sohaib 01-01-2000 -01-31-2004 Department of the Army Conditional Estrogen Receptor Knockout Mouse Model for Studying Mammary Tumorigenesis Role:PI $319,659.00 Closed Level:Federal

Grant: #R01 CA131137 Investigators:Dong, Zhongyun; Khan, Sohaib; Lu, Shan; Wortman, Matthew 09-09-2008 -07-31-2014 National Cancer Institute A Novel Synthetic Androgen Receptor Antagonist Role:Collaborator $1,599,078.00 Active Level:Federal

Peer Reviewed Publications

Jiang, Pingping; Hu, Qiuping; Ito, Mitsuhiro; Meyer, Sara; Waltz, Susan; Khan, Sohaib; Roeder, Robert G; Zhang, Xiaoting (2010. ) Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation.Proceedings of the National Academy of Sciences of the United States of America, , 107 (15 ) ,6765-70 More Information

Naciff, Jorge M; Khambatta, Zubin S; Reichling, Timothy D; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P (2010. ) The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent.Toxicology, , 270 (2-3 ) ,137-49 More Information

Khan, Shah-Naz Hayat; Abruzzo, Todd A; Ringer, Andrew J (2009. ) Successful endovascular reconstruction of acutely ruptured pseudoaneurysm of the vertebral artery, complicated by isolated vertebrobasilar circulation and symptomatic vasospasm.Clinical neurology and neurosurgery, , 111 (10 ) ,868-73 More Information

Naciff, Jorge M; Khambatta, Zubin S; Thomason, Ryan G; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P (2009. ) The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol.Toxicological sciences : an official journal of the Society of Toxicology, , 107 (1 ) ,40-55 More Information

Kojetin, Douglas J; Burris, Thomas P; Jensen, Elwood V; Khan, Sohaib A (2008. ) Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor.Endocrine-related cancer, , 15 (4 ) ,851-70 More Information

Yang, Jun; Singleton, David W; Shaughnessy, Elizabeth A; Khan, Sohaib A (2008. ) The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization.Molecular and cellular endocrinology, , 295 (1-2 ) ,94-100 More Information

Tharakan, Robin; Lepont, Pierig; Singleton, David; Kumar, Rakesh; Khan, Sohaib (2008. ) Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity.Molecular and cellular endocrinology, , 295 (1-2 ) ,70-8 More Information

Feng, Yuxin; Manka, David; Wagner, Kay-Uwe; Khan, Sohaib A (2007. ) Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice.Proceedings of the National Academy of Sciences of the United States of America, , 104 (37 ) ,14718-23 More Information

Ingraham, Susan E; Lynch, Roy A; Surti, Urvashi; Rutter, Joni L; Buckler, Alan J; Khan, Sohaib A; Menon, Anil G; Lepont, Pierig (2006. ) Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma.Mutation research, , 602 (1-2 ) ,43-53 More Information

Singleton, David W; Feng, Yuxin; Yang, Jun; Puga, Alvaro; Lee, Adrian V; Khan, Sohaib A (2006. ) Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells.Environmental research, , 100 (1 ) ,86-92 More Information

Jensen, Elwood V; Khan, Sohaib A A two-site model for antiestrogen action.Mechanisms of ageing and development, , 125 (10-11 ) ,679-82 More Information

Singleton, David W; Feng, Yuxin; Chen, Yangde; Busch, Steve J; Lee, Adrian V; Puga, Alvaro; Khan, Sohaib A (2004. ) Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells.Molecular and cellular endocrinology, , 221 (1-2 ) ,47-55 More Information

Sheeler, Cameron Q; Singleton, David W; Khan, Sobhaib A (2003. ) Mutation of serines 104, 106, and 118 inhibits dimerization of the human estrogen receptor in yeast. Endocrine research, , 29 (2 ) ,237-55

Singleton, David W; Feng, Yuxin; Burd, Craig J; Khan, Sohaib A (2003. ) Nongenomic activity and subsequent c-fos induction by estrogen receptor ligands are not sufficient to promote deoxyribonucleic acid synthesis in human endometrial adenocarcinoma cells. Endocrinology, , 144 (1 ) ,121-8

Singleton, David W; Khan, Sohaib A (2003. ) Xenoestrogen exposure and mechanisms of endocrine disruption. Frontiers in bioscience : a journal and virtual library, , 8 ,s110-8

Puga, A; Barnes, S J; Chang, C; Zhu, H; Nephew, K P; Khan, S A; Shertzer, H G (2000. ) Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemical pharmacology, , 59 (8 ) ,997-1005

Dudley, M W; Sheeler, C Q; Wang, H; Khan, S (2000. ) Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: implications for their mechanism of action.Proceedings of the National Academy of Sciences of the United States of America, , 97 (7 ) ,3696-701 More Information

Nephew, K P; Choi, C M; Polek, T C; McBride, R; Bigsby, R M; Khan, S A; Husseinzadeh, N (2000. ) Expression of fos and jun proto-oncogenes in benign versus malignant human uterine tissue.Gynecologic oncology, , 76 (3 ) ,388-96 More Information

Sheeler, C Q; Dudley, M W; Khan, S A (2000. ) Environmental estrogens induce transcriptionally active estrogen receptor dimers in yeast: activity potentiated by the coactivator RIP140. Environmental health perspectives, , 108 (2 ) ,97-103

Wang, H; Zeng, X; Khan, S A (1999. ) Estrogen receptor variants ERdelta5 and ERdelta7 down-regulate wild-type estrogen receptor activity. Molecular and cellular endocrinology, , 156 (1-2 ) ,159-68

Peters, G A; Khan, S A (1999. ) Estrogen receptor domains E and F: role in dimerization and interaction with coactivator RIP-140. Molecular endocrinology (Baltimore, Md.), , 13 (2 ) ,286-96

Allen, D L; Mitchner, N A; Uveges, T E; Nephew, K P; Khan, S; Ben-Jonathan, N (1997. ) Cell-specific induction of c-fos expression in the pituitary gland by estrogen. Endocrinology, , 138 (5 ) ,2128-35

Moulton, B C; Motz, J; Serdoncillo, C; Akcali, K C; Khan, S A (1997. ) Progesterone withdrawal and RU-486 treatment stimulate apoptosis in specific uterine decidual cells.Cell death and differentiation, , 4 (1 ) ,76-81 More Information

Akcali, K C; Khan, S A; Moulton, B C (1996. ) Effect of decidualization on the expression of bax and bcl-2 in the rat uterine endometrium. Endocrinology, , 137 (7 ) ,3123-31

Meng, J J; Khan, S; Ip, W (1996. ) Intermediate filament protein domain interactions as revealed by two-hybrid screens. The Journal of biological chemistry, , 271 (3 ) ,1599-604

Nephew, K P; Polek, T C; Khan, S A (1996. ) Tamoxifen-induced proto-oncogene expression persists in uterine endometrial epithelium. Endocrinology, , 137 (1 ) ,219-24

Wang, H; Peters, G A; Zeng, X; Tang, M; Ip, W; Khan, S A (1995. ) Yeast two-hybrid system demonstrates that estrogen receptor dimerization is ligand-dependent in vivo. The Journal of biological chemistry, , 270 (40 ) ,23322-9

Nephew, K P; Peters, G A; Khan, S A (1995. ) Cellular localization of estradiol-induced c-fos messenger ribonucleic acid in the rat uterus: c-fos expression and uterine cell proliferation do not correlate strictly. Endocrinology, , 136 (7 ) ,3007-15

Meng, J J; Khan, S; Ip, W (1994. ) Charge interactions in the rod domain drive formation of tetramers during intermediate filament assembly. The Journal of biological chemistry, , 269 (28 ) ,18679-85

Nephew, K P; Tang, M; Khan, S A (1994. ) Estrogen differentially affects c-jun expression in uterine tissue compartments. Endocrinology, , 134 (4 ) ,1827-34

Makarova, I; Carpenter, D; Khan, S; Ip, W (1994. ) A conserved region in the tail domain of vimentin is involved in its assembly into intermediate filaments.Cell motility and the cytoskeleton, , 28 (3 ) ,265-77 More Information

Nephew, K P; Webb, D K; Akcali, K C; Moulton, B C; Khan, S A (1993. ) Hormonal regulation and expression of the jun-D protooncogene in specific cell types of the rat uterus. The Journal of steroid biochemistry and molecular biology, , 46 (3 ) ,281-7

Nephew, K P; Polek, T C; Akcali, K C; Khan, S A (1993. ) The antiestrogen tamoxifen induces c-fos and jun-B, but not c-jun or jun-D, protooncogenes in the rat uterus. Endocrinology, , 133 (1 ) ,419-22

Webb, D K; Moulton, B C; Khan, S A (1993. ) Estrogen induces expression of c-jun and jun-B protooncogenes in specific rat uterine cells. Endocrinology, , 133 (1 ) ,20-8

Cho, F S; Phillips, K S; Khan, S A; Weaver, T E (1993. ) Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues.Biochemical and biophysical research communications, , 191 (3 ) ,860-5 More Information

Moulton, B C; Khan, S A (1992. ) Progestin and estrogen control of cathepsin D expression and processing in rat uterine luminal epithelium and stroma-myometrium. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), , 201 (1 ) ,98-105

Dungy, L J; Siddiqi, T A; Khan, S (1991. ) C-jun and jun-B oncogene expression during placental development. American journal of obstetrics and gynecology, , 165 (6 Pt 1 ) ,1853-6

Dungy, L J; Siddiqi, T A; Khan, S (1991. ) Transforming growth factor-beta 1 expression during placental development. American journal of obstetrics and gynecology, , 165 (4 Pt 1 ) ,853-7

Raza, A; Bokhari, J; Yousuf, N; Mehdi, A; Mazewski, C; Khan, S; Baker, V; Lampkin, B (1991. ) Cell cycle kinetic studies in human cancers. Development of three DNA-specific labels in three decades. Archives of pathology & laboratory medicine, , 115 (9 ) ,873-9

Khan, S A; Moulton, B C (1990. ) Regulation of 3-hydroxyl-3-methylglutaryl-coenzyme A reductase activity in rat uterine tissues. Journal of steroid biochemistry, , 35 (6 ) ,701-4

Webb, D K; Moulton, B C; Khan, S A (1990. ) Estrogen induced expression of the C-jun proto-oncogene in the immature and mature rat uterus. Biochemical and biophysical research communications, , 168 (2 ) ,721-6

Dush, M K; Briggs, M R; Royce, M E; Schaff, D A; Khan, S A; Tischfield, J A; Stambrook, P J (1988. ) Identification of DNA sequences required for mouse APRT gene expression. Nucleic acids research, , 16 (17 ) ,8509-24

Feng, Yuxin; Singleton, David; Guo, Chun; Gardner, Amanda; Pakala, Suresh; Kumar, Rakesh; Jensen, Elwood; Zhang, Jinsong; Khan, Sohaib (2013. ) DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha.PloS one, , 8 (7 ) ,e68075 More Information

Guo, Chun; Gow, Chien-Hung; Li, Yali; Gardner, Amanda; Khan, Sohaib; Zhang, Jinsong (2012. ) Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes.The Journal of biological chemistry, , 287 (15 ) ,12111-20 More Information

Raza, A; Yousuf, N; Bokhari, S A; Mehdi, A; Masterson, M; Lampkin, B; Yanik, G; Mazewski, C; Khan, S; Preisler, H (1992. ) Contribution of in vivo proliferation/differentiation studies toward the development of a combined functional and morphologic system of classification of neoplastic diseases. Cancer, , 69 (6 Suppl ) ,1557-66

Marshall, Aaron M; McClaine, Rebecca J; Gurusamy, Devikala; Gray, Jerilyn K; Lewnard, Kara E; Khan, Sohaib A; Waltz, Susan E (2012. ) Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice.Molecular cancer, , 11 ,2 More Information

Garrison, Jason B; Ge, Chunmin; Che, Lixiao; Pullum, Derek A; Peng, Guang; Khan, Sohaib; Ben-Jonathan, Nira; Wang, Jiang; Du, Chunying (2015. ) Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents.Journal of cancer science & therapy, , 7 (4 ) ,121-126 More Information

Khan, Sohaib; Lingrel, Jerry B (2010. ) Thematic minireview series on nuclear receptors in biology and diseases.The Journal of biological chemistry, , 285 (50 ) ,38741-2 More Information

Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar (2015. ) Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth.Nature communications, , 6 ,8428 More Information

Kadel, Sapana; Ainsua-Enrich, Erola; Hatipoglu, Ibrahim; Turner, Sean; Singh, Simar; Khan, Sohaib; Kovats, Susan (2018. ) A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers.ImmunoHorizons, , 2 (2 ) ,74-86 More Information

Zhang, Jinsong; Gow, Chien-Hung; Khan, Sohaib; Liu, Ying; Yang, Chuanwei (2017. ) Transcriptional and Genomic Control of Stem Cells in Development and Cancer.Stem cells international, , 2017 ,2513598 More Information

1978 -1981 NIH/NCI Young Investigator Award

1990 -1994 External Reviewer, National Research Council of Canada

1991 -1991 Chairman, ASCB Subgroup Meeting on Uterine Biology, Boston

1994 -1994 Inaugural Faculty Achievement Award, University of Cincinnati

1995 -2003 U.S. Army Breast Cancer Research Program Peer Review Panel

2001 -2003 NIH/Reproductive Endocrinology Study Section

2004 -2006 NIH/Molecular & Cellular Endocrinology Study Section

1998 -2001 Member, Editorial Board, Endocrinology

2002 -To Present Member, Editorial Board, Steroids

2002 -2003 Board of Trustees, Ohio Cancer Research Associates Columbus, OH

2002 -2004 Consultant, Proctor & Gamble Co. Cincinnati, OH

2003 -To Present Chair, Organizing Committee, Jensen Symposium on Nuclear Receptors (Reviewed in Molecular Cell, March 2004)

2005 -2007 Associate Editor, Cancer Research

11-2006 -11-2006 Organizing Committee: CSHL Conference on Nuclear Receptors From Bench to Bedside, [Organizers: Ron Evans, Sohaib Khan & Keith Yamamoto], Cold Spring Harbor, NY

07-2008 1st World Cancer Congress “B.I.T. Life Membership Award” Shanghai

08-2008 -08-2008 Organizing Committee: CSHL Conference on Nuclear Receptors From Bench to Bedside, [Organizers: Ron Evans, Sohaib Khan, Charles Sawyer & Keith Yamamoto], Cold Spring Harbor, NY

09-2008 -09-2008 Invited Speaker Nobel Conference on 50th anniversary of Estrogen Receptor Discovery, Stockholm

04-2009 -04-2009 Invited Speaker Wyeth Colloquium “Estrogens, SERMS and TSECs”, Ft. Myers

Molecular Biologist, Biochemist, Developmental Biologist,Biophysical Chemistry and Molecular Biology,Chromatin proteins,Enzyme mechanisms,Lipid chemistry and metabolism,Gene regulation,Protein chemistry,Protein purification,Nucleic acid hybridization,Synthesis of nucleic acid,Developmental Biology,Mammalian (non-human) developmental biology,Cancer,Cytologic diagnosis of cancer

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 513-558-7224
sohaib.khan@uc.edu