Marshall Anderson

Marshall W. Anderson

Professor

Professional Summary

Marshall Anderson, Professor of Cancer and Cell Biology, has a background in mathematics, biometrics, and molecular toxicology. He came to the University of Cincinnati in 1996 as Director of the Department of Environmental Health and joined the Department of Genome Science, now Molecular Oncogenesis in 2004. Dr. Anderson has led many large multi-site studies on the genetics, etiology, and prevention of lung cancer. A recent study by Dr. Anderson's group identified a major susceptibility locus for familial lung cancer. A second area of scientific interest for the Anderson laboratory is the development of chemopreventive strategies to reduce the incidence of lung cancer in high-risk current and former smokers. His group is in the process of examining combinations of agents in several animal models to help develop a strategy for human trials. In particular, they are targeting the AP-1 and NK-kB pathways because of evidence suggesting that these pathways are activated in preneoplastic lesions in the bronchial epithelium.

Education

B.S., Emory and Henry College Emory, VA, 1961 (Chemistry, Math)

Ph.D., University of Tennessee Knoxville, TN, 1965 (Mathematics)

Positions and Work Experience

1966 -1967 Assistant Professor, Department of Mathematics, Univ. of Tennessee, Knoxville, TN

1967 -1969 Member of Technical Staff, Bell Telephone Laboratories,

1969 -1971 Postdoctoral Fellow, Biomathematics Department, North Carolina State Univ., Raleigh, NC

1971 -1974 Senior Staff Fellow, Biometry Branch, NIEHS, Research Triangle Park, NC

1975 -1984 Senior Scientist, Laboratory of Pharmacokinetics and Pharmacology, NIEHS, Research Triangle Park, NC

1984 -1988 Head, Molecular Toxicology Section, Laboratory of Biochemical Risk Analysis , , NIEHS, Research Triangle Park, NC

1989 -1993 Chief, Laboratory of Molecular Toxicology, DBRA, NIEHS, RTP, NC

1993 -1996 Scientific Director, Research Department, St. Mary’s Hospital, Grand Junction, CO

Research Support

Grant: #5U01CA76293-08 Investigators:(Anderson) 03-01-1999 -08-31-2010 NIH/NCI Genetic Epidemiology of Lung Cancer Active

Grant: #5U01ES012770 Investigators:(Bornschein) 09-29-2003 -07-31-2010 NIH/NCI Breast Cancer and the Environment Research Centers: Puberty and Cancer Initiation: Environment, Diet and Obesity Active

Grant: #2 R01 CA058554 Investigators:(You) 04-01-2003 -03-31-2010 NIH/NCI Molecular Genetics of Lung Cancer Tumors Completed

Grant: #R01 CA93643 Investigators:(You) 09-01-2002 -08-31-2007 NIH/NCI Mechanisms of Mouse Lung Carcinogenesis Completed

Grant: #P30ES006096 Investigators:(Anderson) 06-15-1992 -03-31-2007 NIH/NCI Environmental Genetics Completed

Grant: #1-R01-CA-93643-01-A0-S0-E0 Investigators:Anderson, Marshall 12-01-2002 -07-31-2007 National Cancer Institute Mechanism of Mouse Lung Carcinogenesis Role:PI $890,705.00 Active Level:Federal

Grant: #U01 CA076293 Investigators:Anderson, Marshall 09-30-2005 -08-31-2012 National Cancer Institute Genetic Epidemiology of Lung Cancer Role:PI $5,676,163.00 Closed Level:Federal

Grant: #29734E / R01 CA058554 Investigators:Anderson, Marshall 04-01-2005 -02-28-2010 National Cancer Institute Molecular Genetics of Mouse Lung Tumors Role:PI $569,868.00 Active Level:Federal

Grant: #P01 CA096964 Investigators:Anderson, Marshall 05-23-2003 -04-30-2011 National Cancer Institute Chemoprevention of Lung Cancer Role:PI $12,799,793.49 Active Level:Federal

Grant: #5-P30-ES-06096-10-A0-S0-E0 Investigators:Anderson, Marshall 09-30-1997 -03-31-2002 National Institute of Environmental Health Sciences Environmental Genetics Role:PI $6,656,116.24 Closed Level:Federal

Grant: #5-P50-CA-58187-05-A0-S0-E0 Investigators:Anderson, Marshall 09-01-1996 -03-31-2001 National Cancer Institute Analysis of Genetic Alterations and Multiple Loc in Pre-Invasive Lesions Role:PI $369,617.00 Closed Level:Federal

Grant: #5-R01-CA-58554-10-A0-S0-E0 Investigators:Anderson, Marshall 09-01-1998 -06-30-2003 National Cancer Institute Molecular Genetics of Mouse Lung Tumors Role:PI $586,895.00 Closed Level:Federal

Grant: #5-U01-CA-76293-05-A0-S0-E0 Investigators:Anderson, Marshall 05-01-1999 -02-28-2006 National Cancer Institute Genetic Epidemiology of Lung Cancer Role:PI $6,075,950.00 Closed Level:Federal

Grant: #AMBIOSYSTEM-01-01-A0-S0-E0 Investigators:Anderson, Marshall 05-20-1998 -07-30-2000 American Biosystems, Inc. Study to Compare Efficacy of Specimen Adequacy and Diagnostic Cell Yield from Spontaneous Expectoration versus Sputum Induction Role:PI $22,400.00 Closed Level:Industry

Grant: #WU-10-163 / R01 CA134682 Investigators:Anderson, Marshall 07-01-2009 -05-31-2010 National Cancer Institute Genome-wide association studies of inherited predisposition to lung cancer Role:PI $114,021.00 Closed Level:Federal

Grant: #3 U01 CA076293-10S1 Investigators:Anderson, Marshall; Pinney, Susan 09-30-2009 -09-29-2012 National Cancer Institute Genetic Epidemiology of Lung Cancer Role:PI $880,446.00 Closed Level:Federal

Publications

Peer Reviewed Publications

Tichelaar, Jay W; Yan, Ying; Tan, Qing; Wang, Yian; Estensen, Richard D; Young, Matthew R; Colburn, Nancy H; Yin, Hulian; Goodin, Colleen; Anderson, Marshall W; You, Ming (2010. )A Dominant-Negative c-jun Mutant Inhibits Lung Carcinogenesis in Mice.Cancer prevention research (Philadelphia, Pa.), ,

Liu, Pengyuan; Yang, Ping; Wu, Xifeng; Vikis, Haris G; Lu, Yan; Wang, Yian; Schwartz, Ann G; Pinney, Susan M; de Andrade, Mariza; Gazdar, Adi; Gaba, Colette; Mandal, Diptasri; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E; Spitz, Margaret; Amos, Christopher I; Anderson, Marshall W; You, Ming (2010. )A second genetic variant on chromosome 15q24-25.1 associates with lung cancer.Cancer research, ,70 (8 ),3128-35

Amos, Christopher I; Pinney, Susan M; Li, Yafang; Kupert, Elena; Lee, Juwon; de Andrade, Mariza A; Yang, Ping; Schwartz, Ann G; Fain, Pam R; Gazdar, Adi; Minna, John; Wiest, Jonathan S; Zeng, Dong; Rothschild, Henry; Mandal, Diptasri; You, Ming; Coons, Teresa; Gaba, Colette; Bailey-Wilson, Joan E; Anderson, Marshall W (2010. )A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers.Cancer research, ,70 (6 ),2359-67

Liu, Pengyuan; Vikis, Haris G; Lu, Yan; Wang, Yian; Schwartz, Ann G; Pinney, Susan M; Yang, Ping; de Andrade, Mariza; Gazdar, Adi; Gaba, Colette; Mandal, Diptasri; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E; Amos, Christopher I; Anderson, Marshall W; You, Ming (2010. )Cumulative effect of multiple loci on genetic susceptibility to familial lung cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, ,19 (2 ),517-24

Liu, Yan; Liu, Pengyuan; Wen, Weidong; James, Michael A; Wang, Yian; Bailey-Wilson, Joan E; Amos, Christopher I; Pinney, Susan M; Yang, Ping; de Andrade, Mariza; Petersen, Gloria M; Wiest, Jonathan S; Fain, Pamela R; Schwartz, Ann G; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Kupert, Elena; Lee, Juwon; Seminara, Daniela; Minna, John; Anderson, Marshall W; You, Ming (2009. )Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.Cancer research, ,69 (19 ),7844-50

Wang, Jen C; Cruchaga, Carlos; Saccone, Nancy L; Bertelsen, Sarah; Liu, Pengyuan; Budde, John P; Duan, Weimin; Fox, Louis; Grucza, Richard A; Kern, Jason; Mayo, Kevin; Reyes, Oliver; Rice, John; Saccone, Scott F; Spiegel, Noah; Steinbach, Joseph H; Stitzel, Jerry A; Anderson, Marshall W; You, Ming; Stevens, Victoria L; Bierut, Laura J; Goate, Alison M (2009. )Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.Human molecular genetics, ,18 (16 ),3125-35

You, Ming; Wang, Daolong; Liu, Pengyuan; Vikis, Haris; James, Michael; Lu, Yan; Wang, Yian; Wang, Min; Chen, Qiong; Jia, Dongmei; Liu, Yan; Wen, Weidong; Yang, Ping; Sun, Zhifu; Pinney, Susan M; Zheng, Wei; Shu, Xiao-Ou; Long, Jirong; Gao, Yu-Tang; Xiang, Yong-Bing; Chow, Wong-Ho; Rothman, Nat; Petersen, Gloria M; de Andrade, Mariza; Wu, Yanhong; Cunningham, Julie M; Wiest, Jonathan S; Fain, Pamela R; Schwartz, Ann G; Girard, Luc; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Coons, Teresa; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E; Amos, Christopher I; Anderson, Marshall W (2009. )Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.Clinical cancer research : an official journal of the American Association for Cancer Research, ,15 (8 ),2666-74

Lane, Pierre M; Lam, Stephen; McWilliams, Annette; Leriche, Jean C; Anderson, Marshall W; Macaulay, Calum E Confocal fluorescence microendoscopy of bronchial epithelium.Journal of biomedical optics, ,14 (2 ),024008

Liu, Pengyuan; Vikis, Haris G; Wang, Daolong; Lu, Yan; Wang, Yian; Schwartz, Ann G; Pinney, Susan M; Yang, Ping; de Andrade, Mariza; Petersen, Gloria M; Wiest, Jonathan S; Fain, Pamela R; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Coons, Teresa; Lee, Juwon; Kupert, Elena; Seminara, Daniela; Minna, John; Bailey-Wilson, Joan E; Wu, Xifeng; Spitz, Margaret R; Eisen, Timothy; Houlston, Richard S; Amos, Christopher I; Anderson, Marshall W; You, Ming (2008. )Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.Journal of the National Cancer Institute, ,100 (18 ),1326-30

Anderson, Marshall W; Goodin, Colleen; Zhang, Yu; Kim, Sangmi; Estensen, Richard D; Wiedmann, Timothy S; Sekar, Padmini; Buncher, C Ralph; Khoury, Jane C; Garbow, Joel R; You, Ming; Tichelaar, Jay W (2008. )Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice.Carcinogenesis, ,29 (8 ),1594-600

Vikis, Haris; Sato, Mitsuo; James, Michael; Wang, Daolong; Wang, Yian; Wang, Min; Jia, Dongmei; Liu, Yan; Bailey-Wilson, Joan E; Amos, Christopher I; Pinney, Susan M; Petersen, Gloria M; de Andrade, Mariza; Yang, Ping; Wiest, Jonathan S; Fain, Pamela R; Schwartz, Ann G; Gazdar, Adi; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Kupert, Elena; Seminara, Daniela; Viswanathan, Avinash; Govindan, Ramaswamy; Minna, John; Anderson, Marshall W; You, Ming (2007. )EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity.Cancer research, ,67 (10 ),4665-70

Wang, Min; Vikis, Haris G; Wang, Yian; Jia, Dongmei; Wang, Daolong; Bierut, Laura J; Bailey-Wilson, Joan E; Amos, Christopher I; Pinney, Susan M; Petersen, Gloria M; de Andrade, Mariza; Yang, Ping; Wiest, Jonathan S; Fain, Pamela R; Schwartz, Ann G; Gazdar, Adi; Minna, John; Gaba, Colette; Rothschild, Henry; Mandal, Diptasri; Kupert, Elena; Seminara, Daniela; Liu, Yan; Viswanathan, Avinash; Govindan, Ramaswamy; Anderson, Marshall W; You, Ming (2007. )Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.Cancer research, ,67 (1 ),93-9

Tichelaar, Jay W; Zhang, Yu; leRiche, Jean C; Biddinger, Paul W; Lam, Stephen; Anderson, Marshall W (2005. )Increased staining for phospho-Akt, p65/RELA and cIAP-2 in pre-neoplastic human bronchial biopsies.BMC cancer, ,5 ,155

Clark, Adam Michael; Reynolds, Steven H; Anderson, Marshall; Wiest, Jonathan S (2004. )Mutational activation of the MAP3K8 protooncogene in lung cancer.Genes, chromosomes & cancer, ,41 (2 ),99-108

Tichelaar, Jay W; Zhang, Yu; LeRiche, Jean C; Lam, Stephen; Anderson, Marshall W (2004. )Activation of the Akt/nuclear factor-kappaB signaling axis in developing lung neoplasia. Chest, ,125 (5 Suppl ),153S

Herzog, Christopher R; Bodon, Nomar; Pittman, Brian; Maronpot, Robert R; Massey, Thomas E; Anderson, Marshall W; You, Ming; Devereux, Theodora R (2004. )Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression.Oncogene, ,23 (17 ),3033-9

Li, Jie; Zhang, Zhongqiu; Dai, Zunyan; Plass, Christoph; Morrison, Carl; Wang, Yian; Wiest, Jonathan S; Anderson, Marshall W; You, Ming (2003. )LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.Oncogene, ,22 (8 ),1243-6