Koichi Araki

Koichi Araki , PhD

Assistant Professor-Affiliate

Childrens Hospital Bldg R

COM Pediatrics Infectious Diseases - 0054

Publications

Peer Reviewed Publications

Krummey, Scott M; Morris, Anna B; Jacobs, Jesica R; McGuire, Donald J; Ando, Satomi; Tong, Katherine P; Zhang, Weiwen; Robertson, Jennifer; Guasch, Sara A; Araki, Koichi; Larsen, Christian P; Evavold, Brian D; Kissick, Haydn T; Ford, Mandy L (2020. ) CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence.Cell reports, , 30 (5 ) ,1282-1291.e5 More Information

Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Ahmed, Rafi (2019. ) Cytokine-Mediated Regulation of CD8 T-Cell Responses During Acute and Chronic Viral Infection.Cold Spring Harbor perspectives in biology, , 11 (1 ) , More Information

Ahn, Eunseon; Araki, Koichi; Hashimoto, Masao; Li, Weiyan; Riley, James L; Cheung, Jeanne; Sharpe, Arlene H; Freeman, Gordon J; Irving, Bryan A; Ahmed, Rafi (2018. ) Role of PD-1 during effector CD8 T cell differentiation.Proceedings of the National Academy of Sciences of the United States of America, , 115 (18 ) ,4749-4754 More Information

Hashimoto, Masao; Kamphorst, Alice O; Im, Se Jin; Kissick, Haydn T; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi (2018. ) CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions.Annual review of medicine, , 69 ,301-318 More Information

Youngblood, Ben; Hale, J Scott; Kissick, Haydn T; Ahn, Eunseon; Xu, Xiaojin; Wieland, Andreas; Araki, Koichi; West, Erin E; Ghoneim, Hazem E; Fan, Yiping; Dogra, Pranay; Davis, Carl W; Konieczny, Bogumila T; Antia, Rustom; Cheng, Xiaodong; Ahmed, Rafi (2017. ) Effector CD8 T cells dedifferentiate into long-lived memory cells.Nature, , 552 (7685 ) ,404-409 More Information

Araki, Koichi; Morita, Masahiro; Bederman, Annelise G; Konieczny, Bogumila T; Kissick, Haydn T; Sonenberg, Nahum; Ahmed, Rafi (2017. ) Translation is actively regulated during the differentiation of CD8+ effector T cells.Nature immunology, , 18 (9 ) ,1046-1057 More Information

Kamphorst, Alice O; Wieland, Andreas; Nasti, Tahseen; Yang, Shu; Zhang, Ruan; Barber, Daniel L; Konieczny, Bogumila T; Daugherty, Candace Z; Koenig, Lydia; Yu, Ke; Sica, Gabriel L; Sharpe, Arlene H; Freeman, Gordon J; Blazar, Bruce R; Turka, Laurence A; Owonikoko, Taofeek K; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi (2017. ) Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.Science (New York, N.Y.), , 355 (6332 ) ,1423-1427 More Information

Lee, Junghwa; Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Jin, Hyun-Tak; Davis, Carl W; Konieczny, Bogumila T; Spies, Gregory A; McElrath, M Juliana; Ahmed, Rafi (2017. ) Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice.Journal of virology, , 91 (5 ) , More Information

Ye, Lilin; Lee, Junghwa; Xu, Lifan; Mohammed, Ata-Ur-Rasheed; Li, Weiyan; Hale, J Scott; Tan, Wendy G; Wu, Tuoqi; Davis, Carl W; Ahmed, Rafi; Araki, Koichi (2017. ) mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses.Journal of virology, , 91 (4 ) , More Information

Ray, John P; Staron, Matthew M; Shyer, Justin A; Ho, Ping-Chih; Marshall, Heather D; Gray, Simon M; Laidlaw, Brian J; Araki, Koichi; Ahmed, Rafi; Kaech, Susan M; Craft, Joe (2015. ) The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.Immunity, , 43 (4 ) ,690-702 More Information

Kamphorst, Alice O; Araki, Koichi; Ahmed, Rafi (2015. ) Beyond adjuvants: immunomodulation strategies to enhance T cell immunity.Vaccine, , 33 Suppl 2 ,B21-8 More Information

Xu, Xiaojin; Araki, Koichi; Li, Shuzhao; Han, Jin-Hwan; Ye, Lilin; Tan, Wendy G; Konieczny, Bogumila T; Bruinsma, Monique W; Martinez, Jennifer; Pearce, Erika L; Green, Douglas R; Jones, Dean P; Virgin, Herbert W; Ahmed, Rafi (2014. ) Autophagy is essential for effector CD8(+) T cell survival and memory formation.Nature immunology, , 15 (12 ) ,1152-61 More Information

Penaloza-MacMaster, Pablo; Kamphorst, Alice O; Wieland, Andreas; Araki, Koichi; Iyer, Smita S; West, Erin E; O'Mara, Leigh; Yang, Shu; Konieczny, Bogumila T; Sharpe, Arlene H; Freeman, Gordon J; Rudensky, Alexander Y; Ahmed, Rafi (2014. ) Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.The Journal of experimental medicine, , 211 (9 ) ,1905-18 More Information

Araki, Koichi; Ahmed, Rafi (2013. ) AMPK: a metabolic switch for CD8+ T-cell memory.European journal of immunology, , 43 (4 ) ,878-81 More Information

Araki, Koichi; Youngblood, Ben; Ahmed, Rafi (2013. ) Programmed cell death 1-directed immunotherapy for enhancing T-cell function.Cold Spring Harbor symposia on quantitative biology, , 78 ,239-47 More Information

Xu, Xiaojin; Ye, Lilin; Araki, Koichi; Ahmed, Rafi (2012. ) mTOR, linking metabolism and immunity.Seminars in immunology, , 24 (6 ) ,429-35 More Information

Wu, Tuoqi; Wieland, Andreas; Araki, Koichi; Davis, Carl W; Ye, Lilin; Hale, J Scott; Ahmed, Rafi (2012. ) Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation.Proceedings of the National Academy of Sciences of the United States of America, , 109 (25 ) ,9965-70 More Information

Araki, Koichi; Konieczny, Bogumila T (2012. ) Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells.Methods in molecular biology (Clifton, N.J.), , 821 ,305-16 More Information

Araki, Koichi; Ellebedy, Ali H; Ahmed, Rafi (2011. ) TOR in the immune system.Current opinion in cell biology, , 23 (6 ) ,707-15 More Information

West, Erin E; Youngblood, Ben; Tan, Wendy G; Jin, Hyun-Tak; Araki, Koichi; Alexe, Gabriela; Konieczny, Bogumila T; Calpe, Silvia; Freeman, Gordon J; Terhorst, Cox; Haining, W Nicholas; Ahmed, Rafi (2011. ) Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.Immunity, , 35 (2 ) ,285-98 More Information

Ferrer, I R; Araki, K; Ford, M L (2011. ) Paradoxical aspects of rapamycin immunobiology in transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, , 11 (4 ) ,654-9 More Information

Duraiswamy, Jaikumar; Ibegbu, Chris C; Masopust, David; Miller, Joseph D; Araki, Koichi; Doho, Gregory H; Tata, Pramila; Gupta, Satish; Zilliox, Michael J; Nakaya, Helder I; Pulendran, Bali; Haining, W Nicholas; Freeman, Gordon J; Ahmed, Rafi (2011. ) Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.Journal of immunology (Baltimore, Md. : 1950), , 186 (7 ) ,4200-12 More Information

Turner, A P; Shaffer, V O; Araki, K; Martens, C; Turner, P L; Gangappa, S; Ford, M L; Ahmed, R; Kirk, A D; Larsen, C P (2011. ) Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, , 11 (3 ) ,613-8 More Information

Araki, Koichi; Gangappa, Shivaprakash; Dillehay, Dirck L; Rouse, Barry T; Larsen, Christian P; Ahmed, Rafi (2010. ) Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation.The Journal of experimental medicine, , 207 (11 ) ,2355-67 More Information

Jin, Hyun-Tak; Anderson, Ana C; Tan, Wendy G; West, Erin E; Ha, Sang-Jun; Araki, Koichi; Freeman, Gordon J; Kuchroo, Vijay K; Ahmed, Rafi (2010. ) Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America, , 107 (33 ) ,14733-8 More Information

Ferrer, Ivana R; Wagener, Maylene E; Robertson, Jennifer M; Turner, Alexa P; Araki, Koichi; Ahmed, Rafi; Kirk, Allan D; Larsen, Christian P; Ford, Mandy L (2010. ) Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.Journal of immunology (Baltimore, Md. : 1950), , 185 (4 ) ,2004-8 More Information

Araki, Koichi; Youngblood, Ben; Ahmed, Rafi (2010. ) The role of mTOR in memory CD8 T-cell differentiation.Immunological reviews, , 235 (1 ) ,234-43 More Information

Araki, Koichi; Turner, Alexandra P; Shaffer, Virginia Oliva; Gangappa, Shivaprakash; Keller, Susanne A; Bachmann, Martin F; Larsen, Christian P; Ahmed, Rafi (2009. ) mTOR regulates memory CD8 T-cell differentiation.Nature, , 460 (7251 ) ,108-12 More Information

Ha, Sang-Jun; West, Erin E; Araki, Koichi; Smith, Kendall A; Ahmed, Rafi (2008. ) Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.Immunological reviews, , 223 ,317-33 More Information

Takegawa, Yasuhiro; Araki, Kayo; Fujitani, Naoki; Furukawa, Jun-ichi; Sugiyama, Hiroaki; Sakai, Hideaki; Shinohara, Yasuro (2011. ) Simultaneous analysis of heparan sulfate, chondroitin/dermatan sulfates, and hyaluronan disaccharides by glycoblotting-assisted sample preparation followed by single-step zwitter-ionic-hydrophilic interaction chromatography.Analytical chemistry, , 83 (24 ) ,9443-9 More Information

Araki, Kiwako; Shimatani, Kenichiro; Ohara, Masashi (2009. ) Dynamics of distribution and performance of ramets constructing genets: a demographic-genetic study in a clonal plant, Convallaria keiskei.Annals of botany, , 104 (1 ) ,71-9 More Information

Nakamura, Ichiro; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Okumura, Megumi; Taruishi, Midori; Araki, Koichi; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro (2008. ) Development of a serotyping ELISA system for Thailand virus infection.Archives of virology, , 153 (8 ) ,1537-42 More Information

Taruishi, Midori; Yoshimatsu, Kumiko; Araki, Koichi; Okumura, Megumi; Nakamura, Ichiro; Kajino, Kiichi; Arikawa, Jiro (2007. ) Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice.Virology, , 365 (2 ) ,292-301 More Information

Lee, Byoung-Hee; Yoshimatsu, Kumiko; Araki, Koichi; Okumura, Megumi; Nakamura, Ichiro; Arikawa, Jiro (2006. ) A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice.Vaccine, , 24 (15 ) ,2928-34 More Information

Okumura, M; Yoshimatsu, K; Araki, K; Lee, B-H; Asano, A; Agui, T; Arikawa, J (2004. ) Epitope analysis of monoclonal antibody E5/G6, which binds to a linear epitope in the nucleocapsid protein of hantaviruses.Archives of virology, , 149 (12 ) ,2427-34 More Information

Ogino, Michiko; Yoshimatsu, Kumiko; Ebihara, Hideki; Araki, Koichi; Lee, Byoung-Hee; Okumura, Megumi; Arikawa, Jiro (2004. ) Cell fusion activities of Hantaan virus envelope glycoproteins.Journal of virology, , 78 (19 ) ,10776-82 More Information

Araki, K; Yoshimatsu, K; Lee, B-H; Okumura, M; Kariwa, H; Takashima, I; Arikawa, J (2004. ) Age-dependent hantavirus-specific CD8(+) T-cell responses in mice infected with Hantaan virus.Archives of virology, , 149 (7 ) ,1373-82 More Information

Araki, Koichi; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro (2004. ) A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8(+) T-cell responses.Virology, , 322 (2 ) ,318-27 More Information

Lokugamage, Kumari; Kariwa, Hiroaki; Lokugamage, Nandadeva; Miyamoto, Hironobu; Iwasa, Masahiro; Hagiya, Tomohiro; Araki, Koichi; Tachi, Atsushi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Takashima, Ikuo (2004. ) Genetic and antigenic characterization of the Amur virus associated with hemorrhagic fever with renal syndrome.Virus research, , 101 (2 ) ,127-34 More Information

Lokugamage, Kumari; Kariwa, Hiroaki; Lokugamage, Nandadeva; Iwasa, Masahiro; Hagiya, Tomohiro; Araki, Koichi; Tachi, Atsushi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Iwasaki, Takuya; Takashima, Ikuo (2004. ) Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. The Japanese journal of veterinary research, , 51 (3-4 ) ,143-9

Lokugamage, Nandadeva; Kariwa, Hiroaki; Lokugamage, Kumari; Iwasa, Masahiro A; Hagiya, Tomohiro; Yoshii, Kentaro; Tachi, Atsushi; Ando, Shuji; Fukushima, Hiroshi; Tsuchiya, Kimiyuki; Iwasaki, Takuya; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Mizutani, Tetsuya; Osawa, Kazutaka; Sato, Hiroshi; Takashima, Ikuo (2004. ) Epizootiological and epidemiological study of hantavirus infection in Japan.Microbiology and immunology, , 48 (11 ) ,843-51 More Information

Lee, Byoung-Hee; Yoshimatsu, Kumiko; Maeda, Akihiko; Ochiai, Kazuhiko; Morimatsu, Masami; Araki, Koichi; Ogino, Michiko; Morikawa, Shigeru; Arikawa, Jiro (2003. ) Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.Virus research, , 98 (1 ) ,83-91 More Information

Lokugamage, Nandadeva; Kariwa, Hiroaki; Lokugamage, Kumari; Hagiya, Tomohiro; Miyamoto, Hironobu; Iwasa, Masahiro A; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Mizutani, Tetsuya; Takashima, Ikuo (2003. ) Development of an efficient method for recovery of Puumala and Puumala-related viruses by inoculation of Mongolian gerbils.The Journal of veterinary medical science, , 65 (11 ) ,1189-94 More Information

Lee, B-H; Yoshimatsu, K; Araki, K; Ogino, M; Okumura, M; Tsuchiya, K; Kariwa, H; Arikawa, J (2003. ) Detection of antibody for the serodiagnosis of hantavirus infection in different rodent species.Archives of virology, , 148 (10 ) ,1885-97 More Information

Kariwa, H; Tanabe, H; Mizutani, T; Kon, Y; Lokugamage, K; Lokugamage, N; Iwasa, M A; Hagiya, T; Araki, K; Yoshimatsu, K; Arikawa, J; Takashima, I (2003. ) Synthesis of Seoul virus RNA and structural proteins in cultured cells.Archives of virology, , 148 (9 ) ,1671-85 More Information

Miyamoto, H; Kariwa, H; Araki, K; Lokugamage, K; Hayasaka, D; Cui, B Z; Lokugamage, N; Ivanov, L I; Mizutani, T; Iwasa, M A; Yoshimatsu, K; Arikawa, J; Takashima, I (2003. ) Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype.Archives of virology, , 148 (8 ) ,1543-56 More Information

Araki, Koichi; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro (2003. ) Hantavirus-specific CD8(+)-T-cell responses in newborn mice persistently infected with Hantaan virus.Journal of virology, , 77 (15 ) ,8408-17 More Information

Yoshii, Kentarou; Hayasaka, Daisuke; Goto, Akiko; Obara, Mayumi; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Ivanov, Leonoid; Mizutani, Tetsuya; Kariwa, Hiroaki; Takashima, Ikuo (2003. ) Enzyme-linked immunosorbent assay using recombinant antigens expressed in mammalian cells for serodiagnosis of tick-borne encephalitis.Journal of virological methods, , 108 (2 ) ,171-9 More Information

Ogino, Michiko; Ebihara, Hideki; Lee, Byoung-Hee; Araki, Koichi; Lundkvist, Ake; Kawaoka, Yoshihiro; Yoshimatsu, Kumiko; Arikawa, Jiro (2003. ) Use of vesicular stomatitis virus pseudotypes bearing hantaan or seoul virus envelope proteins in a rapid and safe neutralization test.Clinical and diagnostic laboratory immunology, , 10 (1 ) ,154-60 More Information

Yoshimatsu, Kumiko; Lee, Byoung-Hee; Araki, Koichi; Morimatsu, Masami; Ogino, Michiko; Ebihara, Hideki; Arikawa, Jiro (2003. ) The multimerization of hantavirus nucleocapsid protein depends on type-specific epitopes.Journal of virology, , 77 (2 ) ,943-52 More Information

Lokugamage, Kumari; Kariwa, Hiroaki; Hayasaka, Daisuke; Cui, Bai Zhong; Iwasaki, Takuya; Lokugamage, Nandadeva; Ivanov, Leonid I; Volkov, Vladimir I; Demenev, Vladimir A; Slonova, Raisa; Kompanets, Galina; Kushnaryova, Tatyana; Kurata, Takeshi; Maeda, Kenji; Araki, Koichi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Takashima, Ikuo (2002. ) Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia.Emerging infectious diseases, , 8 (8 ) ,768-76 More Information

Kariwa, H; Zhong, C B; Araki, K; Yoshimatsu, K; Lokugamage, K; Lokugamage, N; Murphy, M E; Mizutani, T; Arikawa, J; Fukushima, H; Xiong, H; Jiehua, C; Takashima, I (2001. ) Epizootiological survey of hantavirus among rodent species in Ningxia Hui Autonomous Province, China. The Japanese journal of veterinary research, , 49 (2 ) ,105-14

Araki, K; Yoshimatsu, K; Ogino, M; Ebihara, H; Lundkvist A, ; Kariwa, H; Takashima, I; Arikawa, J (2001. ) Truncated hantavirus nucleocapsid proteins for serotyping Hantaan, Seoul, and Dobrava hantavirus infections.Journal of clinical microbiology, , 39 (7 ) ,2397-404 More Information

Ebihara, H; Yoshimatsu, K; Ogino, M; Araki, K; Ami, Y; Kariwa, H; Takashima, I; Li, D; Arikawa, J (2000. ) Pathogenicity of Hantaan virus in newborn mice: genetic reassortant study demonstrating that a single amino acid change in glycoprotein G1 is related to virulence.Journal of virology, , 74 (19 ) ,9245-55 More Information

Kariwa, H; Yoshimatsu, K; Araki, K; Chayama, K; Kumada, H; Ogino, M; Ebihara, H; Murphy, M E; Mizutani, T; Takashima, I; Arikawa, J (2000. ) Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan.Microbiology and immunology, , 44 (5 ) ,357-62 More Information

Mizutani, T; Inagaki, H; Araki, K; Kariwa, H; Arikawa, J; Takashima, I (1998. ) Inhibition of Borna disease virus replication by ribavirin in persistently infected cells.Archives of virology, , 143 (10 ) ,2039-44 More Information

Truong, Thua Thang; Yoshimatsu, Kumiko; Araki, Koichi; Lee, Byoung-Hee; Nakamura, Ichiro; Endo, Rika; Shimizu, Kenta; Yasuda, Shumpei P; Koma, Takaaki; Taruishi, Midori; Okumura, Megumi; Truong, Uyen Ninh; Arikawa, Jiro (2009. ) Molecular epidemiological and serological studies of hantavirus infection in northern Vietnam.The Journal of veterinary medical science, , 71 (10 ) ,1357-63 More Information

Pattamadilok, Sirima; Lee, Byoung-Hee; Kumperasart, Sanit; Yoshimatsu, Kumiko; Okumura, Megumi; Nakamura, Ichiro; Araki, Koichi; Khoprasert, Yuvaluk; Dangsupa, Prayadh; Panlar, Pornpitak; Jandrig, Burkhard; Krüger, Detlev H; Klempa, Boris; Jäkel, Thomas; Schmidt, Jonas; Ulrich, Rainer; Kariwa, Hiroaki; Arikawa, Jiro (2006. ) Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus. The American journal of tropical medicine and hygiene, , 75 (5 ) ,994-1002

Wang, H; Yoshimatsu, K; Ebihara, H; Ogino, M; Araki, K; Kariwa, H; Wang, Z; Luo, Z; Li, D; Hang, C; Arikawa, J (2000. ) Genetic diversity of hantaviruses isolated in china and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus.Virology, , 278 (2 ) ,332-45 More Information

Sallusto, Federica; Lanzavecchia, Antonio; Araki, Koichi; Ahmed, Rafi (2010. ) From vaccines to memory and back.Immunity, , 33 (4 ) ,451-63 More Information

Contact Information

CCHMC S Building
240 Albert Sabin Way
Cincinnati  Ohio, 45229
Phone: 513-803-1632
koichi.araki@cchmc.org