Koichi Araki, PhD

I received my PhD from Hokkaido University, Japan. During my PhD study, I became interested in infectious diseases and T cell immunity.

In my laboratory, I’ve studied CD8 T cell immunity, which is important for controlling viral infections and intracellular bacterial and parasitic infections. It is now clear that CD8 T cells are also involved in immunity against tumors. There is considerable interest in cancer immunotherapy that stimulates CD8 T cell immunity.

My research focus is to understand the mechanisms of how antigen specific CD8 T cell responses are regulated during acute and chronic infection. I’m looking into investigating the role of 1) translational regulation, 2) mTOR activity, and 3) autophagy in effector, memory and exhausted T cell differentiation. The ultimate goal of my research is to develop novel drugs or strategies from information obtained in my basic studies to cure diseases by modulating the immune system.

My studies of CD8 T cell immunity can help us learn and develop better methods to prevent and treat infectious diseases. It also has applications in immunotherapy for cancer treatment against tumors.

Peer Reviewed Publications

Krummey, Scott M; Morris, Anna B; Jacobs, Jesica R; McGuire, Donald J; Ando, Satomi; Tong, Katherine P; Zhang, Weiwen; Robertson, Jennifer; Guasch, Sara A; Araki, Koichi; Larsen, Christian P; Evavold, Brian D; Kissick, Haydn T; Ford, Mandy L  (2020). CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence. Cell reports, 30 (5) , 1282-1291.e5More Information

Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Ahmed, Rafi  (2019). Cytokine-Mediated Regulation of CD8 T-Cell Responses During Acute and Chronic Viral Infection. Cold Spring Harbor perspectives in biology, 11 (1) More Information

Ahn, Eunseon; Araki, Koichi; Hashimoto, Masao; Li, Weiyan; Riley, James L; Cheung, Jeanne; Sharpe, Arlene H; Freeman, Gordon J; Irving, Bryan A; Ahmed, Rafi  (2018). Role of PD-1 during effector CD8 T cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 115 (18) , 4749-4754More Information

Hashimoto, Masao; Kamphorst, Alice O; Im, Se Jin; Kissick, Haydn T; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi  (2018). CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions. Annual review of medicine, 69, 301-318More Information

Youngblood, Ben; Hale, J Scott; Kissick, Haydn T; Ahn, Eunseon; Xu, Xiaojin; Wieland, Andreas; Araki, Koichi; West, Erin E; Ghoneim, Hazem E; Fan, Yiping; Dogra, Pranay; Davis, Carl W; Konieczny, Bogumila T; Antia, Rustom; Cheng, Xiaodong; Ahmed, Rafi  (2017). Effector CD8 T cells dedifferentiate into long-lived memory cells. Nature, 552 (7685) , 404-409More Information

Araki, Koichi; Morita, Masahiro; Bederman, Annelise G; Konieczny, Bogumila T; Kissick, Haydn T; Sonenberg, Nahum; Ahmed, Rafi  (2017). Translation is actively regulated during the differentiation of CD8+ effector T cells. Nature immunology, 18 (9) , 1046-1057More Information

Kamphorst, Alice O; Wieland, Andreas; Nasti, Tahseen; Yang, Shu; Zhang, Ruan; Barber, Daniel L; Konieczny, Bogumila T; Daugherty, Candace Z; Koenig, Lydia; Yu, Ke; Sica, Gabriel L; Sharpe, Arlene H; Freeman, Gordon J; Blazar, Bruce R; Turka, Laurence A; Owonikoko, Taofeek K; Pillai, Rathi N; Ramalingam, Suresh S; Araki, Koichi; Ahmed, Rafi  (2017). Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science (New York, N.Y.), 355 (6332) , 1423-1427More Information

Lee, Junghwa; Hashimoto, Masao; Im, Se Jin; Araki, Koichi; Jin, Hyun-Tak; Davis, Carl W; Konieczny, Bogumila T; Spies, Gregory A; McElrath, M Juliana; Ahmed, Rafi  (2017). Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice. Journal of virology, 91 (5) More Information

Ye, Lilin; Lee, Junghwa; Xu, Lifan; Mohammed, Ata-Ur-Rasheed; Li, Weiyan; Hale, J Scott; Tan, Wendy G; Wu, Tuoqi; Davis, Carl W; Ahmed, Rafi; Araki, Koichi  (2017). mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses. Journal of virology, 91 (4) More Information

Ray, John P; Staron, Matthew M; Shyer, Justin A; Ho, Ping-Chih; Marshall, Heather D; Gray, Simon M; Laidlaw, Brian J; Araki, Koichi; Ahmed, Rafi; Kaech, Susan M; Craft, Joe  (2015). The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity, 43 (4) , 690-702More Information

Kamphorst, Alice O; Araki, Koichi; Ahmed, Rafi  (2015). Beyond adjuvants: immunomodulation strategies to enhance T cell immunity. Vaccine, 33 Suppl 2, B21-8More Information

Xu, Xiaojin; Araki, Koichi; Li, Shuzhao; Han, Jin-Hwan; Ye, Lilin; Tan, Wendy G; Konieczny, Bogumila T; Bruinsma, Monique W; Martinez, Jennifer; Pearce, Erika L; Green, Douglas R; Jones, Dean P; Virgin, Herbert W; Ahmed, Rafi  (2014). Autophagy is essential for effector CD8(+) T cell survival and memory formation. Nature immunology, 15 (12) , 1152-61More Information

Penaloza-MacMaster, Pablo; Kamphorst, Alice O; Wieland, Andreas; Araki, Koichi; Iyer, Smita S; West, Erin E; O'Mara, Leigh; Yang, Shu; Konieczny, Bogumila T; Sharpe, Arlene H; Freeman, Gordon J; Rudensky, Alexander Y; Ahmed, Rafi  (2014). Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of experimental medicine, 211 (9) , 1905-18More Information

Araki, Koichi; Ahmed, Rafi  (2013). AMPK: a metabolic switch for CD8+ T-cell memory. European journal of immunology, 43 (4) , 878-81More Information

Araki, Koichi; Youngblood, Ben; Ahmed, Rafi  (2013). Programmed cell death 1-directed immunotherapy for enhancing T-cell function. Cold Spring Harbor symposia on quantitative biology, 78, 239-47More Information

Xu, Xiaojin; Ye, Lilin; Araki, Koichi; Ahmed, Rafi  (2012). mTOR, linking metabolism and immunity. Seminars in immunology, 24 (6) , 429-35More Information

Wu, Tuoqi; Wieland, Andreas; Araki, Koichi; Davis, Carl W; Ye, Lilin; Hale, J Scott; Ahmed, Rafi  (2012). Temporal expression of microRNA cluster miR-17-92 regulates effector and memory CD8+ T-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 109 (25) , 9965-70More Information

Araki, Koichi; Konieczny, Bogumila T  (2012). Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells. Methods in molecular biology (Clifton, N.J.), 821, 305-16More Information

Araki, Koichi; Ellebedy, Ali H; Ahmed, Rafi  (2011). TOR in the immune system. Current opinion in cell biology, 23 (6) , 707-15More Information

West, Erin E; Youngblood, Ben; Tan, Wendy G; Jin, Hyun-Tak; Araki, Koichi; Alexe, Gabriela; Konieczny, Bogumila T; Calpe, Silvia; Freeman, Gordon J; Terhorst, Cox; Haining, W Nicholas; Ahmed, Rafi  (2011). Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load. Immunity, 35 (2) , 285-98More Information

Ferrer, I R; Araki, K; Ford, M L  (2011). Paradoxical aspects of rapamycin immunobiology in transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 11 (4) , 654-9More Information

Duraiswamy, Jaikumar; Ibegbu, Chris C; Masopust, David; Miller, Joseph D; Araki, Koichi; Doho, Gregory H; Tata, Pramila; Gupta, Satish; Zilliox, Michael J; Nakaya, Helder I; Pulendran, Bali; Haining, W Nicholas; Freeman, Gordon J; Ahmed, Rafi  (2011). Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. Journal of immunology (Baltimore, Md. : 1950), 186 (7) , 4200-12More Information

Turner, A P; Shaffer, V O; Araki, K; Martens, C; Turner, P L; Gangappa, S; Ford, M L; Ahmed, R; Kirk, A D; Larsen, C P  (2011). Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 11 (3) , 613-8More Information

Araki, Koichi; Gangappa, Shivaprakash; Dillehay, Dirck L; Rouse, Barry T; Larsen, Christian P; Ahmed, Rafi  (2010). Pathogenic virus-specific T cells cause disease during treatment with the calcineurin inhibitor FK506: implications for transplantation. The Journal of experimental medicine, 207 (11) , 2355-67More Information

Jin, Hyun-Tak; Anderson, Ana C; Tan, Wendy G; West, Erin E; Ha, Sang-Jun; Araki, Koichi; Freeman, Gordon J; Kuchroo, Vijay K; Ahmed, Rafi  (2010). Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America, 107 (33) , 14733-8More Information

Ferrer, Ivana R; Wagener, Maylene E; Robertson, Jennifer M; Turner, Alexa P; Araki, Koichi; Ahmed, Rafi; Kirk, Allan D; Larsen, Christian P; Ford, Mandy L  (2010). Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. Journal of immunology (Baltimore, Md. : 1950), 185 (4) , 2004-8More Information

Araki, Koichi; Youngblood, Ben; Ahmed, Rafi  (2010). The role of mTOR in memory CD8 T-cell differentiation. Immunological reviews, 235 (1) , 234-43More Information

Araki, Koichi; Turner, Alexandra P; Shaffer, Virginia Oliva; Gangappa, Shivaprakash; Keller, Susanne A; Bachmann, Martin F; Larsen, Christian P; Ahmed, Rafi  (2009). mTOR regulates memory CD8 T-cell differentiation. Nature, 460 (7251) , 108-12More Information

Ha, Sang-Jun; West, Erin E; Araki, Koichi; Smith, Kendall A; Ahmed, Rafi  (2008). Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections. Immunological reviews, 223, 317-33More Information

Takegawa, Yasuhiro; Araki, Kayo; Fujitani, Naoki; Furukawa, Jun-ichi; Sugiyama, Hiroaki; Sakai, Hideaki; Shinohara, Yasuro  (2011). Simultaneous analysis of heparan sulfate, chondroitin/dermatan sulfates, and hyaluronan disaccharides by glycoblotting-assisted sample preparation followed by single-step zwitter-ionic-hydrophilic interaction chromatography. Analytical chemistry, 83 (24) , 9443-9More Information

Araki, Kiwako; Shimatani, Kenichiro; Ohara, Masashi  (2009). Dynamics of distribution and performance of ramets constructing genets: a demographic-genetic study in a clonal plant, Convallaria keiskei. Annals of botany, 104 (1) , 71-9More Information

Nakamura, Ichiro; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Okumura, Megumi; Taruishi, Midori; Araki, Koichi; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro  (2008). Development of a serotyping ELISA system for Thailand virus infection. Archives of virology, 153 (8) , 1537-42More Information

Taruishi, Midori; Yoshimatsu, Kumiko; Araki, Koichi; Okumura, Megumi; Nakamura, Ichiro; Kajino, Kiichi; Arikawa, Jiro  (2007). Analysis of the immune response of Hantaan virus nucleocapsid protein-specific CD8+ T cells in mice. Virology, 365 (2) , 292-301More Information

Lee, Byoung-Hee; Yoshimatsu, Kumiko; Araki, Koichi; Okumura, Megumi; Nakamura, Ichiro; Arikawa, Jiro  (2006). A pseudotype vesicular stomatitis virus containing Hantaan virus envelope glycoproteins G1 and G2 as an alternative to hantavirus vaccine in mice. Vaccine, 24 (15) , 2928-34More Information

Okumura, M; Yoshimatsu, K; Araki, K; Lee, B-H; Asano, A; Agui, T; Arikawa, J  (2004). Epitope analysis of monoclonal antibody E5/G6, which binds to a linear epitope in the nucleocapsid protein of hantaviruses. Archives of virology, 149 (12) , 2427-34More Information

Ogino, Michiko; Yoshimatsu, Kumiko; Ebihara, Hideki; Araki, Koichi; Lee, Byoung-Hee; Okumura, Megumi; Arikawa, Jiro  (2004). Cell fusion activities of Hantaan virus envelope glycoproteins. Journal of virology, 78 (19) , 10776-82More Information

Araki, K; Yoshimatsu, K; Lee, B-H; Okumura, M; Kariwa, H; Takashima, I; Arikawa, J  (2004). Age-dependent hantavirus-specific CD8(+) T-cell responses in mice infected with Hantaan virus. Archives of virology, 149 (7) , 1373-82More Information

Araki, Koichi; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro  (2004). A new model of Hantaan virus persistence in mice: the balance between HTNV infection and CD8(+) T-cell responses. Virology, 322 (2) , 318-27More Information

Lokugamage, Kumari; Kariwa, Hiroaki; Lokugamage, Nandadeva; Miyamoto, Hironobu; Iwasa, Masahiro; Hagiya, Tomohiro; Araki, Koichi; Tachi, Atsushi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Takashima, Ikuo  (2004). Genetic and antigenic characterization of the Amur virus associated with hemorrhagic fever with renal syndrome. Virus research, 101 (2) , 127-34More Information

Lokugamage, Kumari; Kariwa, Hiroaki; Lokugamage, Nandadeva; Iwasa, Masahiro; Hagiya, Tomohiro; Araki, Koichi; Tachi, Atsushi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Iwasaki, Takuya; Takashima, Ikuo  (2004). Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. The Japanese journal of veterinary research, 51 (3-4) , 143-9

Lokugamage, Nandadeva; Kariwa, Hiroaki; Lokugamage, Kumari; Iwasa, Masahiro A; Hagiya, Tomohiro; Yoshii, Kentaro; Tachi, Atsushi; Ando, Shuji; Fukushima, Hiroshi; Tsuchiya, Kimiyuki; Iwasaki, Takuya; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Mizutani, Tetsuya; Osawa, Kazutaka; Sato, Hiroshi; Takashima, Ikuo  (2004). Epizootiological and epidemiological study of hantavirus infection in Japan. Microbiology and immunology, 48 (11) , 843-51More Information

Lee, Byoung-Hee; Yoshimatsu, Kumiko; Maeda, Akihiko; Ochiai, Kazuhiko; Morimatsu, Masami; Araki, Koichi; Ogino, Michiko; Morikawa, Shigeru; Arikawa, Jiro  (2003). Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules. Virus research, 98 (1) , 83-91More Information

Lokugamage, Nandadeva; Kariwa, Hiroaki; Lokugamage, Kumari; Hagiya, Tomohiro; Miyamoto, Hironobu; Iwasa, Masahiro A; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Mizutani, Tetsuya; Takashima, Ikuo  (2003). Development of an efficient method for recovery of Puumala and Puumala-related viruses by inoculation of Mongolian gerbils. The Journal of veterinary medical science, 65 (11) , 1189-94More Information

Lee, B-H; Yoshimatsu, K; Araki, K; Ogino, M; Okumura, M; Tsuchiya, K; Kariwa, H; Arikawa, J  (2003). Detection of antibody for the serodiagnosis of hantavirus infection in different rodent species. Archives of virology, 148 (10) , 1885-97More Information

Kariwa, H; Tanabe, H; Mizutani, T; Kon, Y; Lokugamage, K; Lokugamage, N; Iwasa, M A; Hagiya, T; Araki, K; Yoshimatsu, K; Arikawa, J; Takashima, I  (2003). Synthesis of Seoul virus RNA and structural proteins in cultured cells. Archives of virology, 148 (9) , 1671-85More Information

Miyamoto, H; Kariwa, H; Araki, K; Lokugamage, K; Hayasaka, D; Cui, B Z; Lokugamage, N; Ivanov, L I; Mizutani, T; Iwasa, M A; Yoshimatsu, K; Arikawa, J; Takashima, I  (2003). Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. Archives of virology, 148 (8) , 1543-56More Information

Araki, Koichi; Yoshimatsu, Kumiko; Lee, Byoung-Hee; Kariwa, Hiroaki; Takashima, Ikuo; Arikawa, Jiro  (2003). Hantavirus-specific CD8(+)-T-cell responses in newborn mice persistently infected with Hantaan virus. Journal of virology, 77 (15) , 8408-17More Information

Yoshii, Kentarou; Hayasaka, Daisuke; Goto, Akiko; Obara, Mayumi; Araki, Koichi; Yoshimatsu, Kumiko; Arikawa, Jiro; Ivanov, Leonoid; Mizutani, Tetsuya; Kariwa, Hiroaki; Takashima, Ikuo  (2003). Enzyme-linked immunosorbent assay using recombinant antigens expressed in mammalian cells for serodiagnosis of tick-borne encephalitis. Journal of virological methods, 108 (2) , 171-9More Information

Ogino, Michiko; Ebihara, Hideki; Lee, Byoung-Hee; Araki, Koichi; Lundkvist, Ake; Kawaoka, Yoshihiro; Yoshimatsu, Kumiko; Arikawa, Jiro  (2003). Use of vesicular stomatitis virus pseudotypes bearing hantaan or seoul virus envelope proteins in a rapid and safe neutralization test. Clinical and diagnostic laboratory immunology, 10 (1) , 154-60More Information

Yoshimatsu, Kumiko; Lee, Byoung-Hee; Araki, Koichi; Morimatsu, Masami; Ogino, Michiko; Ebihara, Hideki; Arikawa, Jiro  (2003). The multimerization of hantavirus nucleocapsid protein depends on type-specific epitopes. Journal of virology, 77 (2) , 943-52More Information

Lokugamage, Kumari; Kariwa, Hiroaki; Hayasaka, Daisuke; Cui, Bai Zhong; Iwasaki, Takuya; Lokugamage, Nandadeva; Ivanov, Leonid I; Volkov, Vladimir I; Demenev, Vladimir A; Slonova, Raisa; Kompanets, Galina; Kushnaryova, Tatyana; Kurata, Takeshi; Maeda, Kenji; Araki, Koichi; Mizutani, Tetsuya; Yoshimatsu, Kumiko; Arikawa, Jiro; Takashima, Ikuo  (2002). Genetic characterization of hantaviruses transmitted by the Korean field mouse (Apodemus peninsulae), Far East Russia. Emerging infectious diseases, 8 (8) , 768-76More Information

Kariwa, H; Zhong, C B; Araki, K; Yoshimatsu, K; Lokugamage, K; Lokugamage, N; Murphy, M E; Mizutani, T; Arikawa, J; Fukushima, H; Xiong, H; Jiehua, C; Takashima, I  (2001). Epizootiological survey of hantavirus among rodent species in Ningxia Hui Autonomous Province, China. The Japanese journal of veterinary research, 49 (2) , 105-14

Araki, K; Yoshimatsu, K; Ogino, M; Ebihara, H; Lundkvist A, ; Kariwa, H; Takashima, I; Arikawa, J  (2001). Truncated hantavirus nucleocapsid proteins for serotyping Hantaan, Seoul, and Dobrava hantavirus infections. Journal of clinical microbiology, 39 (7) , 2397-404More Information

Ebihara, H; Yoshimatsu, K; Ogino, M; Araki, K; Ami, Y; Kariwa, H; Takashima, I; Li, D; Arikawa, J  (2000). Pathogenicity of Hantaan virus in newborn mice: genetic reassortant study demonstrating that a single amino acid change in glycoprotein G1 is related to virulence. Journal of virology, 74 (19) , 9245-55More Information

Kariwa, H; Yoshimatsu, K; Araki, K; Chayama, K; Kumada, H; Ogino, M; Ebihara, H; Murphy, M E; Mizutani, T; Takashima, I; Arikawa, J  (2000). Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan. Microbiology and immunology, 44 (5) , 357-62More Information

Mizutani, T; Inagaki, H; Araki, K; Kariwa, H; Arikawa, J; Takashima, I  (1998). Inhibition of Borna disease virus replication by ribavirin in persistently infected cells. Archives of virology, 143 (10) , 2039-44More Information

Truong, Thua Thang; Yoshimatsu, Kumiko; Araki, Koichi; Lee, Byoung-Hee; Nakamura, Ichiro; Endo, Rika; Shimizu, Kenta; Yasuda, Shumpei P; Koma, Takaaki; Taruishi, Midori; Okumura, Megumi; Truong, Uyen Ninh; Arikawa, Jiro  (2009). Molecular epidemiological and serological studies of hantavirus infection in northern Vietnam. The Journal of veterinary medical science, 71 (10) , 1357-63More Information

Pattamadilok, Sirima; Lee, Byoung-Hee; Kumperasart, Sanit; Yoshimatsu, Kumiko; Okumura, Megumi; Nakamura, Ichiro; Araki, Koichi; Khoprasert, Yuvaluk; Dangsupa, Prayadh; Panlar, Pornpitak; Jandrig, Burkhard; Krüger, Detlev H; Klempa, Boris; Jäkel, Thomas; Schmidt, Jonas; Ulrich, Rainer; Kariwa, Hiroaki; Arikawa, Jiro  (2006). Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus. The American journal of tropical medicine and hygiene, 75 (5) , 994-1002

Wang, H; Yoshimatsu, K; Ebihara, H; Ogino, M; Araki, K; Kariwa, H; Wang, Z; Luo, Z; Li, D; Hang, C; Arikawa, J  (2000). Genetic diversity of hantaviruses isolated in china and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus. Virology, 278 (2) , 332-45More Information

Sallusto, Federica; Lanzavecchia, Antonio; Araki, Koichi; Ahmed, Rafi  (2010). From vaccines to memory and back. Immunity, 33 (4) , 451-63More Information

Chen, Chao; Zheng, Hong; Horwitz, Edwin M; Ando, Satomi; Araki, Koichi; Zhao, Peng; Li, Zhiguo; Ford, Mandy L; Ahmed, Rafi; Qu, Cheng-Kui  (2023). Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity. Science advances, 9 (49) , eadf9522More Information

Gill, Amanda L; Wang, Peter H; Lee, Judong; Hudson, William H; Ando, Satomi; Araki, Koichi; Hu, Yinghong; Wieland, Andreas; Im, Sejin; Gavora, Autumn; Medina, Christopher B; Freeman, Gordon J; Hashimoto, Masao; Reiner, Steven L; Ahmed, Rafi  (2023). PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Science immunology, 8 (86) , eadg0539More Information

Ando, Satomi; Perkins, Charles M; Sajiki, Yamato; Chastain, Chase; Valanparambil, Rajesh M; Wieland, Andreas; Hudson, William H; Hashimoto, Masao; Ramalingam, Suresh S; Freeman, Gordon J; Ahmed, Rafi; Araki, Koichi  (2023). mTOR regulates T cell exhaustion and PD-1-targeted immunotherapy response during chronic viral infection. The Journal of clinical investigation, 133 (2) More Information

Hashimoto, Masao; Araki, Koichi; Cardenas, Maria A; Li, Peng; Jadhav, Rohit R; Kissick, Haydn T; Hudson, William H; McGuire, Donald J; Obeng, Rebecca C; Wieland, Andreas; Lee, Judong; McManus, Daniel T; Ross, James L; Im, Se Jin; Lee, Junghwa; Lin, Jian-Xin; Hu, Bin; West, Erin E; Scharer, Christopher D; Freeman, Gordon J; Sharpe, Arlene H; Ramalingam, Suresh S; Pellerin, Alex; Teichgräber, Volker; Greenleaf, William J; Klein, Christian; Goronzy, Jorg J; Umaña, Pablo; Leonard, Warren J; Smith, Kendall A; Ahmed, Rafi  (2022). PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program. Nature, 610 (7930) , 173-181More Information

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Phone: 513-803-1632
koichi.araki@cchmc.org