Lesley Arnold

Lesley Arnold

Professor of Psychiatry; Director of the Women’s Health Research Program

One Stetson Square

COM Psychiatry Clinical Research - 0559

Stetson Building
Suite 3200
Cincinnati, Ohio 45219

Professional Summary

Dr. Arnold is a Professor of Psychiatry. She is the Director of the Women’s Health Research Program for the Department of Psychiatry and conducts research full time. Dr. Arnold graduated from Cornell University with a B.A. in 1981 and received her M.D. from the University of Cincinnati College of Medicine in 1986.

Her research interests include Fibromyalgia, Chronic Pain, Women’s Health, and Mood and Anxiety Disorders.

Education

Bachelor's Degree, Cornell University

Medical Degree, University of Cincinnati College of Medicine

Residency, University of Cincinnati College of Medicine

Research and Practice Interests

Research interests include Fibromyalgia, Chronic Pain, Women’s Health, and Mood and Anxiety Disorders.

UC Health Clinical Focus

Psychiatry

UC Health Specialities

Psychiatry

Research Support

Grant: #CHMC 397 / AR050028 Investigators:Arnold, Lesley 07-01-2004 -06-30-2009 National Institute of Arthritis, Musculoskeletal and Skin Disease Randomized Clinical Trial in Juvenile Fibromyalgia Role:PI $81,120.00 Closed Level:Federal

Grant: #5-N01-AR-9-2235-04-A0-S0-E0 Investigators:Arnold, Lesley 09-30-2000 -09-30-2004 National Institute of Arthritis, Musculoskeletal and Skin Disease Fibromyalgia Family Study Role:PI $24,607.00 Closed Level:Federal

Investigators:Arnold, Lesley 09-30-2002 -06-30-2006 National Institute of Arthritis, Musculoskeletal and Skin Disease Phase II Double-Blind Placebo-Controlled Trial of Gabapentin in the Treatment of Fibromyalgia Role:PI $2,474,716.02 Closed Level:Federal

Grant: #5-R01-AR-46054-03-A0-S0-E0 Investigators:Arnold, Lesley 07-01-1999 -06-30-2003 National Institute of Arthritis, Musculoskeletal and Skin Disease A Controlled Family Study in Patients with Fibromyalgia Role:PI $648,568.00 Closed Level:Federal

Grant: #R01 AR053207 Investigators:Arnold, Lesley 05-18-2007 -04-30-2012 National Institute of Arthritis, Musculoskeletal and Skin Disease Development of Fibromyalgia Responder Index Role:PI $1,062,117.00 Closed Level:Federal

Grant: #CHMC 105591 / R01 AR054842 Investigators:Arnold, Lesley 08-01-2009 -07-31-2013 National Institute of Arthritis, Musculoskeletal and Skin Disease Longitudinal Determination of Outcomes of Adolescents with Fibromyalgia Role:PI $72,704.00 Active Level:Federal

Grant: #CK #1006212888 Investigators:Arnold, Lesley 07-01-2010 -06-30-2011 Pfizer, Inc. Pfizer Visiting Professorships in Neurology/Psychiatry Role:PI $7,500.00 Closed Level:Industry

Grant: #Midwestern Pain Consortium - Consortium Agreement Investigators:Arnold, Lesley 12-04-2013 -12-03-2018 Eli Lilly and Company Midwestern Pain Consortium - Consortium Agreement Role:PI $.00 Active Level:Industry

Grant: #Midwestern Pain Consortium - Lilly Member Organization Agmt Investigators:Arnold, Lesley 12-04-2013 -12-03-2018 Eli Lilly and Company Midwestern CTSA Pain Consortium - Lilly Member Organization Agmt Role:PI $400,000.00 Active Level:Industry

Publications

Peer Reviewed Publications

Kashikar-Zuck, Susmita; Johnston, Megan; Ting, Tracy V; Graham, Brent T; Lynch-Jordan, Anne M; Verkamp, Emily; Passo, Murray; Schikler, Kenneth N; Hashkes, Philip J; Spalding, Steven; Banez, Gerard; Richards, Margaret M; Powers, Scott W; Arnold, Lesley M; Lovell, Daniel (2010. )Relationship between School Absenteeism and Depressive Symptoms among Adolescents with Juvenile Fibromyalgia.Journal of pediatric psychology, ,35 (9 ),996-1004

Arnold, Lesley M; Clauw, Daniel; Wang, Fujun; Ahl, Jonna; Gaynor, Paula J; Wohlreich, Madelaine M (2010. )Flexible Dosed Duloxetine in the Treatment of Fibromyalgia: A Randomized, Double-blind, Placebo-controlled Trial.The Journal of rheumatology, ,

Kashikar-Zuck, Susmita; Flowers, Stacy R; Verkamp, Emily; Ting, Tracy V; Lynch-Jordan, Anne M; Graham, T Brent; Passo, Murray; Schikler, Kenneth N; Hashkes, Philip J; Spalding, Steven; Banez, Gerard; Richards, Margaret M; Powers, Scott W; Arnold, Lesley M; Lovell, Daniel (2010. )Actigraphy-based physical activity monitoring in adolescents with juvenile primary fibromyalgia syndrome.The journal of pain : official journal of the American Pain Society, ,11 (9 ),885-93

Arnold, Lesley M; Clauw, Daniel J (2010. )Fibromyalgia syndrome: practical strategies for improving diagnosis and patient outcomes.The American journal of medicine, ,123 (6 ),S2

Arnold, Lesley M (2010. )The pathophysiology, diagnosis and treatment of fibromyalgia.The Psychiatric clinics of North America, ,33 (2 ),375-408

Arnold, Lesley M; Gendreau, R Michael; Palmer, Robert H; Gendreau, Judy F; Wang, Yong (2010. )Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: Results of a randomized, double-blind, placebo-controlled trial.Arthritis and rheumatism, ,

Arnold, Lesley; Mease, Philip; Silverman, Stuart (2010. )Pregabalin: an alpha2-delta (alpha2-delta) ligand for the management of fibromyalgia. The American journal of managed care, ,16 (5 Suppl ),S138-43

Arnold, Lesley M (2009. )Strategies for managing fibromyalgia.The American journal of medicine, ,122 (12 Suppl ),S31-43

Hudson, James I; Arnold, Lesley M; Bradley, Laurence A; Choy, Ernest H S; Mease, Philip J; Wang, Fujun; Ahl, Jonna; Wohlreich, Madelaine M (2009. )What makes patients with fibromyalgia feel better? Correlations between Patient Global Impression of Improvement and changes in clinical symptoms and function: a pooled analysis of 4 randomized placebo-controlled trials of duloxetine.The Journal of rheumatology, ,36 (11 ),2517-22

Arnold, Lesley M (2009. )Advances in the management of fibromyalgia. CNS spectrums, ,14 (10 Suppl 8 ),12-6; discussion 17-

Choy, Ernest H; Arnold, Lesley M; Clauw, Daniel J; Crofford, Leslie J; Glass, Jennifer M; Simon, Lee S; Martin, Susan A; Strand, C Vibeke; Williams, David A; Mease, Philip J (2009. )Content and criterion validity of the preliminary core dataset for clinical trials in fibromyalgia syndrome.The Journal of rheumatology, ,36 (10 ),2330-4

Mease, Philip; Arnold, Lesley M; Choy, Ernest H; Clauw, Daniel J; Crofford, Leslie J; Glass, Jennifer M; Martin, Susan A; Morea, Jessica; Simon, Lee; Strand, C Vibeke; Williams, David A (2009. )Fibromyalgia syndrome module at OMERACT 9: domain construct.The Journal of rheumatology, ,36 (10 ),2318-29

Arnold, Lesley M; Hudson, James I; Wang, Fujun; Wohlreich, Madelaine M; Prakash, Apurva; Kajdasz, Daniel K; Chappell, Amy S Comparisons of the efficacy and safety of duloxetine for the treatment of fibromyalgia in patients with versus without major depressive disorder.The Clinical journal of pain, ,25 (6 ),461-8

Arnold, Lesley M (2009. )Pain and the brain: chronic widespread pain. The Journal of clinical psychiatry, ,70 (4 ),e10

Arnold, Lesley M; Bradley, Laurence A; Clauw, Daniel J; Glass, Jennifer M; Goldenberg, Don L (2008. )Multidisciplinary care and stepwise treatment for fibromyalgia. The Journal of clinical psychiatry, ,69 (12 ),e35

Arnold, Lesley M; Clauw, Daniel J; Wohlreich, Madelaine M; Wang, Fujun; Ahl, Jonna; Gaynor, Paula J; Chappell, Amy S (2009. )Efficacy of duloxetine in patients with fibromyalgia: pooled analysis of 4 placebo-controlled clinical trials.Primary care companion to the Journal of clinical psychiatry, ,11 (5 ),237-44

Arnold, Lesley M; Bradley, Laurence A; Clauw, Daniel J; Glass, Jennifer M; Goldenberg, Don L (2008. )Evaluating and diagnosing fibromyalgia and comorbid psychiatric disorders. The Journal of clinical psychiatry, ,69 (10 ),e28

Arnold, Lesley M; Jain, Rakesh; Glazer, William M (2008. )Pain and the brain. The Journal of clinical psychiatry, ,69 (9 ),e25

Arnold, Lesley M; Meyers, Adam L; Sunderajan, Prabha; Montano, C Brendan; Kass, Ethan; Trivedi, Madhukar; Wohlreich, Madelaine M The effect of pain on outcomes in a trial of duloxetine treatment of major depressive disorder.Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, ,20 (4 ),187-93

Arnold, Lesley M; Crofford, Leslie J; Mease, Philip J; Burgess, Somali Misra; Palmer, Susan C; Abetz, Linda; Martin, Susan A (2008. )Patient perspectives on the impact of fibromyalgia.Patient education and counseling, ,73 (1 ),114-20

Arnold, Lesley M; Russell, I Jon; Diri, E W; Duan, W Rachel; Young, James P; Sharma, Uma; Martin, Susan A; Barrett, Jeannette A; Haig, George (2008. )A 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgia.The journal of pain : official journal of the American Pain Society, ,9 (9 ),792-805

Mease, Phillip J; Arnold, Lesley M; Crofford, Leslie J; Williams, David A; Russell, I Jon; Humphrey, Louise; Abetz, Linda; Martin, Susan A (2008. )Identifying the clinical domains of fibromyalgia: contributions from clinician and patient Delphi exercises.Arthritis and rheumatism, ,59 (7 ),952-60

Russell, I Jon; Mease, Philip J; Smith, Timothy R; Kajdasz, Daniel K; Wohlreich, Madelaine M; Detke, Michael J; Walker, Daniel J; Chappell, Amy S; Arnold, Lesley M (2008. )Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: Results from a 6-month, randomized, double-blind, placebo-controlled, fixed-dose trial.Pain, ,136 (3 ),432-44

Arnold, Lesley M Understanding fatigue in major depressive disorder and other medical disorders.Psychosomatics, ,49 (3 ),185-90

Mease, Philip J; Russell, I Jon; Arnold, Lesley M; Florian, Hana; Young, James P; Martin, Susan A; Sharma, Uma (2008. )A randomized, double-blind, placebo-controlled, phase III trial of pregabalin in the treatment of patients with fibromyalgia. The Journal of rheumatology, ,35 (3 ),502-14

Lawrence, Reva C; Felson, David T; Helmick, Charles G; Arnold, Lesley M; Choi, Hyon; Deyo, Richard A; Gabriel, Sherine; Hirsch, Rosemarie; Hochberg, Marc C; Hunder, Gene G; Jordan, Joanne M; Katz, Jeffrey N; Kremers, Hilal Maradit; Wolfe, Frederick (2008. )Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.Arthritis and rheumatism, ,58 (1 ),26-35

Arnold, Lesley M (2008. )Management of fibromyalgia and comorbid psychiatric disorders. The Journal of clinical psychiatry, ,69 Suppl 2 ,14-9

Arnold, Lesley M; Crofford, Leslie J; Martin, Susan A; Young, James P; Sharma, Uma The effect of anxiety and depression on improvements in pain in a randomized, controlled trial of pregabalin for treatment of fibromyalgia.Pain medicine (Malden, Mass.), ,8 (8 ),633-8

Arnold, Lesley M; Pritchett, Yili Lu; D'Souza, Deborah N; Kajdasz, Daniel K; Iyengar, Smriti; Wernicke, Joachim F (2007. )Duloxetine for the treatment of fibromyalgia in women: pooled results from two randomized, placebo-controlled clinical trials.Journal of women's health (2002), ,16 (8 ),1145-56

Arnold, Lesley M (2007. )Duloxetine and other antidepressants in the treatment of patients with fibromyalgia.Pain medicine (Malden, Mass.), ,8 Suppl 2 ,S63-74

Pigott, Teresa A; Prakash, Apurva; Arnold, Lesley M; Aaronson, Scott T; Mallinckrodt, Craig H; Wohlreich, Madelaine M (2007. )Duloxetine versus escitalopram and placebo: an 8-month, double-blind trial in patients with major depressive disorder.Current medical research and opinion, ,23 (6 ),1303-18

Mease, Philip; Arnold, Lesley M; Bennett, Robert; Boonen, Annelies; Buskila, Dan; Carville, Serena; Chappell, Amy; Choy, Ernest; Clauw, Daniel; Dadabhoy, Dina; Gendreau, Michael; Goldenberg, Don; Littlejohn, Geoffrey; Martin, Susan; Perera, Philip; Russell, I Jon; Simon, Lee; Spaeth, Michael; Williams, David; Crofford, Leslie (2007. )Fibromyalgia syndrome. The Journal of rheumatology, ,34 (6 ),1415-25

Arnold, Lesley M; Goldenberg, Don L; Stanford, Sharon B; Lalonde, Justine K; Sandhu, H S; Keck, Paul E; Welge, Jeffrey A; Bishop, Fred; Stanford, Kevin E; Hess, Evelyn V; Hudson, James I (2007. )Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trial.Arthritis and rheumatism, ,56 (4 ),1336-44

Strakowski, Stephen M; DelBello, Melissa P; Fleck, David E; Adler, Caleb M; Anthenelli, Robert M; Keck, Paul E; Arnold, Lesley M; Amicone, Jennifer (2007. )Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania.Archives of general psychiatry, ,64 (1 ),57-64

Arnold, Lesley M; Hudson, James I; Keck, Paul E; Auchenbach, Megan B; Javaras, Kristin N; Hess, Evelyn V (2006. )Comorbidity of fibromyalgia and psychiatric disorders. The Journal of clinical psychiatry, ,67 (8 ),1219-25

Arnold, Lesley M (2006. )Management of psychiatric comorbidity in fibromyalgia. Current psychiatry reports, ,8 (3 ),241-5

Bennett, Aurora J; Arnold, Lesley M; Welge, Jeffrey A Use of standardized patients during a psychiatry clerkship.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, ,30 (3 ),185-90

Arnold, Lesley M (2006. )Biology and therapy of fibromyalgia. New therapies in fibromyalgia.Arthritis research & therapy, ,8 (4 ),212

Arnold, Lesley M; Rosen, Amy; Pritchett, Yili Lu; D'Souza, Deborah N; Goldstein, David J; Iyengar, Smriti; Wernicke, Joachim F (2005. )A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder.Pain, ,119 (1-3 ),5-15

Arnold, Lesley M (2005. )The nature of painful and somatic complaints in depressive disorders. CNS spectrums, ,10 (12 Suppl 19 ),4-5

Bennett, Aurora J; Roman, Brenda; Arnold, Lesley M; Kay, Jerald; Goldenhar, Linda M Professionalism deficits among medical students: models of identification and intervention.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, ,29 (5 ),426-32

Mease, Philip J; Clauw, Daniel J; Arnold, Lesley M; Goldenberg, Don L; Witter, James; Williams, David A; Simon, Lee S; Strand, C Vibeke; Bramson, Candace; Martin, Susan; Wright, Timothy M; Littman, Bruce; Wernicke, J F; Gendreau, R Michael; Crofford, Leslie J (2005. )Fibromyalgia syndrome. The Journal of rheumatology, ,32 (11 ),2270-7

Strakowski, Stephen M; DelBello, Melissa P; Fleck, David E; Adler, Caleb M; Anthenelli, Robert M; Keck, Paul E; Arnold, Lesley M; Amicone, Jennifer (2005. )Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania.Archives of general psychiatry, ,62 (8 ),851-8

Hudson, James I; Arnold, Lesley M; Keck, Paul E; Auchenbach, Megan B; Pope, Harrison G (2004. )Family study of fibromyalgia and affective spectrum disorder.Biological psychiatry, ,56 (11 ),884-91

Arnold, Lesley M; Hudson, James I (2004. )Comment on: Familial aggregation of depression in fibromyalgia: a community-based test of alternative hypotheses, Raphael et al., Pain 110 (2004) 449-460.Pain, ,112 (3 ),409-10; author reply

McElroy, Susan L; Shapira, Nathan A; Arnold, Lesley M; Keck, Paul E; Rosenthal, Norman R; Wu, Shu-Chen; Capece, Julie A; Fazzio, Lydia; Hudson, James I (2004. )Topiramate in the long-term treatment of binge-eating disorder associated with obesity. The Journal of clinical psychiatry, ,65 (11 ),1463-9

Bennett, Aurora J; Arnold, Lesley M (2004. )Use of a computerized evaluation system in a psychiatry clerkship.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, ,28 (3 ),197-203

Arnold, Lesley M; Lu, Yili; Crofford, Leslie J; Wohlreich, Madelaine; Detke, Michael J; Iyengar, Smriti; Goldstein, David J (2004. )A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder.Arthritis and rheumatism, ,50 (9 ),2974-84

Arnold, Lesley M; Keck, Paul E; Collins, Jacqueline; Wilson, Rodgers; Fleck, David E; Corey, Kimberly B; Amicone, Jennifer; Adebimpe, Victor R; Strakowski, Stephen M (2004. )Ethnicity and first-rank symptoms in patients with psychosis.Schizophrenia research, ,67 (2-3 ),207-12

Arnold, Lesley M; Hudson, James I; Hess, Evelyn V; Ware, Avis E; Fritz, Deborah A; Auchenbach, Megan B; Starck, Linsey O; Keck, Paul E (2004. )Family study of fibromyalgia.Arthritis and rheumatism, ,50 (3 ),944-52

Arnold, Lesley M; Strakowski, Stephen M; Schwiers, Michael L; Amicone, Jennifer; Fleck, David E; Corey, Kimberly B; Farrow, Jenni E (2004. )Sex, ethnicity, and antipsychotic medication use in patients with psychosis.Schizophrenia research, ,66 (2-3 ),169-75

Arnold, Lesley M (2003. )Gender differences in bipolar disorder. The Psychiatric clinics of North America, ,26 (3 ),595-620

Strakowski, Stephen M; Keck, Paul E; Arnold, Lesley M; Collins, Jacqueline; Wilson, Rodgers M; Fleck, David E; Corey, Kimberly B; Amicone, Jennifer; Adebimpe, Victor R (2003. )Ethnicity and diagnosis in patients with affective disorders. The Journal of clinical psychiatry, ,64 (7 ),747-54

McElroy, Susan L; Arnold, Lesley M; Shapira, Nathan A; Keck, Paul E; Rosenthal, Norman R; Karim, M Rezaul; Kamin, Marc; Hudson, James I (2003. )Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial. The American journal of psychiatry, ,160 (2 ),255-61

Arnold, Lesley M; McElroy, Susan L; Hudson, James I; Welge, Jeffrey A; Bennett, Aurora J; Keck, Paul E (2002. )A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder. The Journal of clinical psychiatry, ,63 (11 ),1028-33

Arnold, Lesley M (2002. )Phenomenology and therapeutic options for dermatotillomania.Expert review of neurotherapeutics, ,2 (5 ),725-30

Arnold, Lesley M; Hess, Evelyn V; Hudson, James I; Welge, Jeffrey A; Berno, Sarah E; Keck, Paul E (2002. )A randomized, placebo-controlled, double-blind, flexible-dose study of fluoxetine in the treatment of women with fibromyalgia. The American journal of medicine, ,112 (3 ),191-7

Arnold, Lesley M. (1999. )A Case Series of Women With Postpartum-Onset Obsessive-Compulsive Disorder. Primary care companion to the Journal of clinical psychiatry, ,1 (4 ),103-108

Other Information

Lesley Arnold, MD, is a doctor with University of Cincinnati Physicians.

Practice Location:
UC Health Psychiatry (Stetson Building)
260 Stetson Street
Suite 3200
Cincinnati, OH 45219

Clinical Specialties:
Psychiatry/Psychology, Fibromyalgia, Chronic Fatigue Syndrome, Depression, Women's Health Research Program

To make an appointment, please call (513) 475-8000.

 

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Contact Information

Academic - Stetson Building
Suite 3200
Cincinnati  Ohio, 45219
Phone: 513-558-7700
lesley.arnold@uc.edu