Mohammad Azam

Doctorate, JNU, New Delhi, India

Postdoctoral Fellow, Massachusetts Institute of Technology

Postdoctoral Fellow, Children’s Hospital of Boston

Peer Reviewed Publications

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad (2015. )Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.Scientific reports, ,5 ,14538

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Azam, Mohammad (2014. )A method for screening and validation of resistant mutations against kinase inhibitors.Journal of visualized experiments : JoVE, ,(94 ),

Kamthan, Ayushi; Kamthan, Mohan; Azam, Mohammad; Chakraborty, Niranjan; Chakraborty, Subhra; Datta, Asis (2012. )Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality.Scientific reports, ,2 ,951

Azam, Mohammad; Powers, John T; Einhorn, William; Huang, Wei-Sheng; Shakespeare, William C; Zhu, Xiaotian; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K; Daley, George Q (2010. )AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance.Chemical biology & drug design, ,75 (2 ),223-7

Zhang, Jianming; Adrián, Francisco J; Jahnke, Wolfgang; Cowan-Jacob, Sandra W; Li, Allen G; Iacob, Roxana E; Sim, Taebo; Powers, John; Dierks, Christine; Sun, Fangxian; Guo, Gui-Rong; Ding, Qiang; Okram, Barun; Choi, Yongmun; Wojciechowski, Amy; Deng, Xianming; Liu, Guoxun; Fendrich, Gabriele; Strauss, André; Vajpai, Navratna; Grzesiek, Stephan; Tuntland, Tove; Liu, Yi; Bursulaya, Badry; Azam, Mohammad; Manley, Paul W; Engen, John R; Daley, George Q; Warmuth, Markus; Gray, Nathanael S (2010. )Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.Nature, ,463 (7280 ),501-6

Huang, Wei-Sheng; Zhu, Xiaotian; Wang, Yihan; Azam, Mohammad; Wen, David; Sundaramoorthi, Raji; Thomas, R Mathew; Liu, Shuangying; Banda, Geetha; Lentini, Scott P; Das, Sasmita; Xu, Qihong; Keats, Jeff; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T; Broudy, Marc I; Russian, Karin; Daley, George Q; Iuliucci, John; Dalgarno, David C; Clackson, Tim; Sawyer, Tomi K; Shakespeare, William C (2009. )9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.Journal of medicinal chemistry, ,52 (15 ),4743-56

Viswanathan, Srinivas R; Powers, John T; Einhorn, William; Hoshida, Yujin; Ng, Tony L; Toffanin, Sara; O'Sullivan, Maureen; Lu, Jun; Phillips, Letha A; Lockhart, Victoria L; Shah, Samar P; Tanwar, Pradeep S; Mermel, Craig H; Beroukhim, Rameen; Azam, Mohammad; Teixeira, Jose; Meyerson, Matthew; Hughes, Timothy P; Llovet, Josep M; Radich, Jerald; Mullighan, Charles G; Golub, Todd R; Sorensen, Poul H; Daley, George Q (2009. )Lin28 promotes transformation and is associated with advanced human malignancies.Nature genetics, ,41 (7 ),843-8

Nardi, Valentina; Naveiras, Olaia; Azam, Mohammad; Daley, George Q (2009. )ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.Blood, ,113 (16 ),3813-20

Azam, Mohammad; Seeliger, Markus A; Gray, Nathanael S; Kuriyan, John; Daley, George Q (2008. )Activation of tyrosine kinases by mutation of the gatekeeper threonine.Nature structural & molecular biology, ,15 (10 ),1109-18

Raz, Tal; Nardi, Valentina; Azam, Mohammad; Cortes, Jorge; Daley, George Q (2007. )Farnesyl transferase inhibitor resistance probed by target mutagenesis.Blood, ,110 (6 ),2102-9

Azam, Mohammad; Nardi, Valentina; Shakespeare, William C; Metcalf, Chester A; Bohacek, Regine S; Wang, Yihan; Sundaramoorthi, Raji; Sliz, Piotr; Veach, Darren R; Bornmann, William G; Clarkson, Bayard; Dalgarno, David C; Sawyer, Tomi K; Daley, George Q (2006. )Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.Proceedings of the National Academy of Sciences of the United States of America, ,103 (24 ),9244-9

Weisberg, Ellen; Manley, Paul W; Breitenstein, Werner; Brüggen, Josef; Cowan-Jacob, Sandra W; Ray, Arghya; Huntly, Brian; Fabbro, Doriano; Fendrich, Gabriele; Hall-Meyers, Elizabeth; Kung, Andrew L; Mestan, Jürgen; Daley, George Q; Callahan, Linda; Catley, Laurie; Cavazza, Cara; Azam, Mohammad; Mohammed, Azam; Neuberg, Donna; Wright, Renee D; Gilliland, D Gary; Griffin, James D (2005. )Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.Cancer cell, ,7 (2 ),129-41

Nardi, Valentina; Azam, Mohammad; Daley, George Q (2004. )Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Current opinion in hematology, ,11 (1 ),35-43

Azam, Mohammad; Latek, Robert R; Daley, George Q (2003. )Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell, ,112 (6 ),831-43

Azam, Mohammad; Raz, Tal; Nardi, Valentina; Opitz, Sarah L.; Daley, George Q. (2003. )A screen to identify drug resistant variants to target-directed anti-cancer agents.Biological procedures online, ,5 ,204-210

Azam, Mohammad; Kesarwani, Meenu; Chakraborty, Subhra; Natarajan, Krishnamurthy; Datta, Asis (2002. )Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes.The Biochemical journal, ,367 (Pt 1 ),67-75

Khanna, Richie; Chang, Seon H; Andrabi, Shaida; Azam, Mohammad; Kim, Anthony; Rivera, Alicia; Brugnara, Carlo; Low, Philip S; Liu, Shih-Chun; Chishti, Athar H (2002. )Headpiece domain of dematin is required for the stability of the erythrocyte membrane.Proceedings of the National Academy of Sciences of the United States of America, ,99 (10 ),6637-42

Academic - Cincinnati Childrens Hospital Medical Center
3333 Burnet Avenue, ML 7013
Cincinnati  Ohio, 45229
Phone: (513) 803-1413
mohammad.azam@cchmc.org