Mohammad Azam

Mohammad Azam

Associate Professor-Affiliate

Medical Sciences Building

COM Pathology & Lab Medicine - 0529

Cincinnati Childrens Hospital Medical Center
3333 Burnet Avenue, ML 7013
Cincinnati, Ohio 45229

Education

Doctorate, JNU, New Delhi, India

Postdoctoral Fellow, Massachusetts Institute of Technology

Postdoctoral Fellow, Children’s Hospital of Boston

Publications

Peer Reviewed Publications

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad (2015. ) Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.Scientific reports, , 5 ,14538

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Azam, Mohammad (2014. ) A method for screening and validation of resistant mutations against kinase inhibitors.Journal of visualized experiments : JoVE, , (94 ) ,

Kamthan, Ayushi; Kamthan, Mohan; Azam, Mohammad; Chakraborty, Niranjan; Chakraborty, Subhra; Datta, Asis (2012. ) Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality.Scientific reports, , 2 ,951

Azam, Mohammad; Powers, John T; Einhorn, William; Huang, Wei-Sheng; Shakespeare, William C; Zhu, Xiaotian; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K; Daley, George Q (2010. ) AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance.Chemical biology & drug design, , 75 (2 ) ,223-7

Zhang, Jianming; Adrián, Francisco J; Jahnke, Wolfgang; Cowan-Jacob, Sandra W; Li, Allen G; Iacob, Roxana E; Sim, Taebo; Powers, John; Dierks, Christine; Sun, Fangxian; Guo, Gui-Rong; Ding, Qiang; Okram, Barun; Choi, Yongmun; Wojciechowski, Amy; Deng, Xianming; Liu, Guoxun; Fendrich, Gabriele; Strauss, André; Vajpai, Navratna; Grzesiek, Stephan; Tuntland, Tove; Liu, Yi; Bursulaya, Badry; Azam, Mohammad; Manley, Paul W; Engen, John R; Daley, George Q; Warmuth, Markus; Gray, Nathanael S (2010. ) Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.Nature, , 463 (7280 ) ,501-6

Huang, Wei-Sheng; Zhu, Xiaotian; Wang, Yihan; Azam, Mohammad; Wen, David; Sundaramoorthi, Raji; Thomas, R Mathew; Liu, Shuangying; Banda, Geetha; Lentini, Scott P; Das, Sasmita; Xu, Qihong; Keats, Jeff; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T; Broudy, Marc I; Russian, Karin; Daley, George Q; Iuliucci, John; Dalgarno, David C; Clackson, Tim; Sawyer, Tomi K; Shakespeare, William C (2009. ) 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.Journal of medicinal chemistry, , 52 (15 ) ,4743-56

Viswanathan, Srinivas R; Powers, John T; Einhorn, William; Hoshida, Yujin; Ng, Tony L; Toffanin, Sara; O'Sullivan, Maureen; Lu, Jun; Phillips, Letha A; Lockhart, Victoria L; Shah, Samar P; Tanwar, Pradeep S; Mermel, Craig H; Beroukhim, Rameen; Azam, Mohammad; Teixeira, Jose; Meyerson, Matthew; Hughes, Timothy P; Llovet, Josep M; Radich, Jerald; Mullighan, Charles G; Golub, Todd R; Sorensen, Poul H; Daley, George Q (2009. ) Lin28 promotes transformation and is associated with advanced human malignancies.Nature genetics, , 41 (7 ) ,843-8

Nardi, Valentina; Naveiras, Olaia; Azam, Mohammad; Daley, George Q (2009. ) ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.Blood, , 113 (16 ) ,3813-20

Azam, Mohammad; Seeliger, Markus A; Gray, Nathanael S; Kuriyan, John; Daley, George Q (2008. ) Activation of tyrosine kinases by mutation of the gatekeeper threonine.Nature structural & molecular biology, , 15 (10 ) ,1109-18

Raz, Tal; Nardi, Valentina; Azam, Mohammad; Cortes, Jorge; Daley, George Q (2007. ) Farnesyl transferase inhibitor resistance probed by target mutagenesis.Blood, , 110 (6 ) ,2102-9

Azam, Mohammad; Nardi, Valentina; Shakespeare, William C; Metcalf, Chester A; Bohacek, Regine S; Wang, Yihan; Sundaramoorthi, Raji; Sliz, Piotr; Veach, Darren R; Bornmann, William G; Clarkson, Bayard; Dalgarno, David C; Sawyer, Tomi K; Daley, George Q (2006. ) Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.Proceedings of the National Academy of Sciences of the United States of America, , 103 (24 ) ,9244-9

Weisberg, Ellen; Manley, Paul W; Breitenstein, Werner; Brüggen, Josef; Cowan-Jacob, Sandra W; Ray, Arghya; Huntly, Brian; Fabbro, Doriano; Fendrich, Gabriele; Hall-Meyers, Elizabeth; Kung, Andrew L; Mestan, Jürgen; Daley, George Q; Callahan, Linda; Catley, Laurie; Cavazza, Cara; Azam, Mohammad; Mohammed, Azam; Neuberg, Donna; Wright, Renee D; Gilliland, D Gary; Griffin, James D (2005. ) Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.Cancer cell, , 7 (2 ) ,129-41

Nardi, Valentina; Azam, Mohammad; Daley, George Q (2004. ) Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Current opinion in hematology, , 11 (1 ) ,35-43

Azam, Mohammad; Latek, Robert R; Daley, George Q (2003. ) Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell, , 112 (6 ) ,831-43

Azam, Mohammad; Raz, Tal; Nardi, Valentina; Opitz, Sarah L.; Daley, George Q. (2003. ) A screen to identify drug resistant variants to target-directed anti-cancer agents.Biological procedures online, , 5 ,204-210

Azam, Mohammad; Kesarwani, Meenu; Chakraborty, Subhra; Natarajan, Krishnamurthy; Datta, Asis (2002. ) Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes.The Biochemical journal, , 367 (Pt 1 ) ,67-75

Khanna, Richie; Chang, Seon H; Andrabi, Shaida; Azam, Mohammad; Kim, Anthony; Rivera, Alicia; Brugnara, Carlo; Low, Philip S; Liu, Shih-Chun; Chishti, Athar H (2002. ) Headpiece domain of dematin is required for the stability of the erythrocyte membrane.Proceedings of the National Academy of Sciences of the United States of America, , 99 (10 ) ,6637-42

Dwivedi, Pankaj; Chutipongtanate, Somchai; Muench, David E; Azam, Mohammad; Grimes, Harry Leighton; Greis, Kenneth D (2020. ) SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling.Proteomics. Clinical applications, , 14 (5 ) ,e1900144

Ramkissoon, Annmarie; Chaney, Katherine E; Milewski, David; Williams, Kyle B; Williams, Rory L; Choi, Kwangmin; Miller, Adam; Kalin, Tanya V; Pressey, Joseph G; Szabo, Sara; Azam, Mohammad; Largaespada, David A; Ratner, Nancy (2019. ) Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK.Clinical cancer research : an official journal of the American Association for Cancer Research, , 25 (13 ) ,4117-4127

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D (2019. ) Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors.Scientific data, , 6 (1 ) ,21

Lin, Peipei; Ren, Yanling; Yan, Xiaomei; Luo, Yingwan; Zhang, Hua; Kesarwani, Meenu; Bu, Jiachen; Zhan, Di; Zhou, Yile; Tang, Yuting; Zhu, Shuanghong; Xu, Weilai; Zhou, Xinping; Mei, Chen; Ma, Liya; Ye, Li; Hu, Chao; Azam, Mohammad; Ding, Wei; Jin, Jie; Huang, Gang; Tong, Hongyan (2019. ) The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes.Haematologica, , 104 (3 ) ,485-496

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad (2019. ) Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.Journal of visualized experiments : JoVE, , (143 ) ,

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D (2019. ) Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors.Leukemia, , 33 (1 ) ,75-87

Wang, Jieyu; Hayashi, Yoshihiro; Yokota, Asumi; Xu, Zefeng; Zhang, Yue; Huang, Rui; Yan, Xiaomei; Liu, Hongyun; Ma, Liping; Azam, Mohammad; Bridges, James P; Cancelas, Jose A; Kalfa, Theodosia A; An, Xiuli; Xiao, Zhijian; Huang, Gang (2018. ) Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.Haematologica, , 103 (1 ) ,40-50

Cui, Pei-Pei; Zhang, Xiu-Du; Wang, Peng; Zhao, Yue; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin (2017. ) Zinc(II) and Copper(II) Hybrid Frameworks via Metal-Ion Metathesis with Enhanced Gas Uptake and Photoluminescence Properties.Inorganic chemistry, , 56 (22 ) ,14157-14163

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad (2017. ) MEK/ERK addiction in CNL/aCML.Oncotarget, , 8 (59 ) ,99215-99216

Azam, Mohammad; Al-Resayes, Saud I; Soliman, Saied M; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Khan, Zahid (2017. ) A (salicylaldiminato)Pt(II) complex with dimethylpropylene linkage: Synthesis, structural characterization and antineoplastic activity.Journal of photochemistry and photobiology. B, Biology, , 176 ,150-156

Liu, Zhi-Qiang; Zhao, Yue; Zhang, Xiu-Du; Kang, Yan-Shang; Lu, Qing-Yi; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin (2017. ) Metal-organic frameworks with 1,4-di(1H-imidazol-4-yl)benzene and varied carboxylate ligands for selectively sensing Fe(iii) ions and ketone molecules.Dalton transactions (Cambridge, England : 2003), , 46 (40 ) ,13943-13951

Wang, Peng; Chen, Kai; Liu, Qing; Wang, Huai-Wei; Azam, Mohammad; Al-Resayes, Saud I; Lu, Yi; Sun, Wei-Yin (2017. ) Fine tuning of catalytic and sorption properties of metal-organic frameworks via in situ ligand exchange.Dalton transactions (Cambridge, England : 2003), , 46 (34 ) ,11425-11430

Liu, Zhi-Qiang; Zhao, Yue; Wang, Peng; Kang, Yan-Shang; Azam, Mohammad; Al-Resayes, Saud I; Liu, Xiao-Hui; Lu, Qing-Yi; Sun, Wei-Yin (2017. ) Fluorescent sensing and selective adsorption properties of metal-organic frameworks with mixed tricarboxylate and 1H-imidazol-4-yl-containing ligands.Dalton transactions (Cambridge, England : 2003), , 46 (28 ) ,9022-9029

Kesarwani, Meenu; Kincaid, Zachary; Gomaa, Ahmed; Huber, Erika; Rohrabaugh, Sara; Siddiqui, Zain; Bouso, Muhammad F; Latif, Tahir; Xu, Ming; Komurov, Kakajan; Mulloy, James C; Cancelas, Jose A; Grimes, H Leighton; Azam, Mohammad (2017. ) Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.Nature medicine, , 23 (4 ) ,472-482

Zhang, Xin; Jia, Deyong; Ao, Junping; Liu, Huijuan; Zang, Yi; Azam, Mohammad; Habib, Samy L; Li, Jia; Ruan, Xinsen; Jia, Hao; Wang, Xueying; Li, Baojie (2016. ) Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia.Oncotarget, , 7 (43 ) ,69945-69960

Azam, Mohammad; Velmurugan, Gunasekaran; Wabaidur, Saikh Mohammad; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Al-Resayes, Saud I; Al-Othman, Zeid A; Venuvanalingam, Ponnambalam (2016. ) Structural elucidation and physicochemical properties of mononuclear Uranyl(VI) complexes incorporating dianionic units.Scientific reports, , 6 ,32898

Azam, Mohammad Nurul; Shahjahan, Mohammad; Yeasmin, Mahbuba; Ahmed, Nasar U (2016. ) Prevalence of Smokeless Tobacco among Low Socioeconomic Populations: A Cross-Sectional Analysis.PloS one, , 11 (6 ) ,e0156887

Sallam, Mowaffaq Awad; Sheikh, Kamaludin Ahmed; Baxendale, Ronald; Azam, Mohammad Nurul; El-Setouhy, Maged (2016. ) The physiological and perceptual effects of plant extracts (Catha Edulis Forsk) during sustained exercise.Substance abuse treatment, prevention, and policy, , 11 (1 ) ,18

Dwivedi, Pankaj; Chutipongtanate, Somchai; Muench, David E; Azam, Mohammad; Grimes, Harry Leighton; Greis, Kenneth D (2020. ) SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling.Proteomics. Clinical applications, , 14 (5 ) ,e1900144

Ramkissoon, Annmarie; Chaney, Katherine E; Milewski, David; Williams, Kyle B; Williams, Rory L; Choi, Kwangmin; Miller, Adam; Kalin, Tanya V; Pressey, Joseph G; Szabo, Sara; Azam, Mohammad; Largaespada, David A; Ratner, Nancy (2019. ) Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK.Clinical cancer research : an official journal of the American Association for Cancer Research, , 25 (13 ) ,4117-4127

Lin, Peipei; Ren, Yanling; Yan, Xiaomei; Luo, Yingwan; Zhang, Hua; Kesarwani, Meenu; Bu, Jiachen; Zhan, Di; Zhou, Yile; Tang, Yuting; Zhu, Shuanghong; Xu, Weilai; Zhou, Xinping; Mei, Chen; Ma, Liya; Ye, Li; Hu, Chao; Azam, Mohammad; Ding, Wei; Jin, Jie; Huang, Gang; Tong, Hongyan (2019. ) The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes.Haematologica, , 104 (3 ) ,485-496

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad (2019. ) Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.Journal of visualized experiments : JoVE, , (143 ) ,

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D (2019. ) Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors.Leukemia, , 33 (1 ) ,75-87

Azam, Mohammad; Al-Resayes, Saud I; Wabaidur, Saikh Mohammad; Altaf, Mohammad; Chaurasia, Bhaskar; Alam, Mahboob; Shukla, Satyendra Nath; Gaur, Pratiksha; Albaqami, Nader Talmas M; Islam, Mohammad Shahidul; Park, Soonheum (2018. ) Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand.Molecules (Basel, Switzerland), , 23 (4 ) ,

Sallam, Mowaffaq Awad; Sheikh, Kamaludin Ahmed; Baxendale, Ronald; Azam, Mohammad Nurul; Hossain, Anwar M; El-Setouhy, Maged (2018. ) The Physiological and Ergogenic Effects of Khat (Catha edulis Forsk) Extract.Substance use & misuse, , 53 (1 ) ,94-100

Wang, Jieyu; Hayashi, Yoshihiro; Yokota, Asumi; Xu, Zefeng; Zhang, Yue; Huang, Rui; Yan, Xiaomei; Liu, Hongyun; Ma, Liping; Azam, Mohammad; Bridges, James P; Cancelas, Jose A; Kalfa, Theodosia A; An, Xiuli; Xiao, Zhijian; Huang, Gang (2018. ) Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.Haematologica, , 103 (1 ) ,40-50

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad (2017. ) MEK/ERK addiction in CNL/aCML.Oncotarget, , 8 (59 ) ,99215-99216

Azam, Mohammad; Al-Resayes, Saud I; Soliman, Saied M; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Khan, Zahid (2017. ) A (salicylaldiminato)Pt(II) complex with dimethylpropylene linkage: Synthesis, structural characterization and antineoplastic activity.Journal of photochemistry and photobiology. B, Biology, , 176 ,150-156

Liu, Zhi-Qiang; Zhao, Yue; Zhang, Xiu-Du; Kang, Yan-Shang; Lu, Qing-Yi; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin (2017. ) Metal-organic frameworks with 1,4-di(1H-imidazol-4-yl)benzene and varied carboxylate ligands for selectively sensing Fe(iii) ions and ketone molecules.Dalton transactions (Cambridge, England : 2003), , 46 (40 ) ,13943-13951

Wang, Peng; Chen, Kai; Liu, Qing; Wang, Huai-Wei; Azam, Mohammad; Al-Resayes, Saud I; Lu, Yi; Sun, Wei-Yin (2017. ) Fine tuning of catalytic and sorption properties of metal-organic frameworks via in situ ligand exchange.Dalton transactions (Cambridge, England : 2003), , 46 (34 ) ,11425-11430

Liu, Zhi-Qiang; Zhao, Yue; Wang, Peng; Kang, Yan-Shang; Azam, Mohammad; Al-Resayes, Saud I; Liu, Xiao-Hui; Lu, Qing-Yi; Sun, Wei-Yin (2017. ) Fluorescent sensing and selective adsorption properties of metal-organic frameworks with mixed tricarboxylate and 1H-imidazol-4-yl-containing ligands.Dalton transactions (Cambridge, England : 2003), , 46 (28 ) ,9022-9029

Kesarwani, Meenu; Kincaid, Zachary; Gomaa, Ahmed; Huber, Erika; Rohrabaugh, Sara; Siddiqui, Zain; Bouso, Muhammad F; Latif, Tahir; Xu, Ming; Komurov, Kakajan; Mulloy, James C; Cancelas, Jose A; Grimes, H Leighton; Azam, Mohammad (2017. ) Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.Nature medicine, , 23 (4 ) ,472-482

Zhang, Xin; Jia, Deyong; Ao, Junping; Liu, Huijuan; Zang, Yi; Azam, Mohammad; Habib, Samy L; Li, Jia; Ruan, Xinsen; Jia, Hao; Wang, Xueying; Li, Baojie (2016. ) Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia.Oncotarget, , 7 (43 ) ,69945-69960

Azam, Mohammad; Velmurugan, Gunasekaran; Wabaidur, Saikh Mohammad; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Al-Resayes, Saud I; Al-Othman, Zeid A; Venuvanalingam, Ponnambalam (2016. ) Structural elucidation and physicochemical properties of mononuclear Uranyl(VI) complexes incorporating dianionic units.Scientific reports, , 6 ,32898

kesarwani (2017. ) Nature medicine, ,

Kesarwani (2017. ) Fos and Dusp1 confer oncogene dependence in CML .Nature Medcine, ,

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D (2019. ) Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors.Scientific data, , 6 (1 ) ,21

Azam, Mohammad (2012. ) An in vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents.Methods in molecular biology (Clifton, N.J.), , 928 ,175-84

Azam, Mohammad; Daley, George Q (2006. ) Anticipating clinical resistance to target-directed agents : the BCR-ABL paradigm.Molecular diagnosis & therapy, , 10 (2 ) ,67-76

Rohrabaugh, S; Kesarwani, M; Kincaid, Z; Huber, E; Leddonne, J; Siddiqui, Z; Khalifa, Y; Komurov, K; Grimes, H L; Azam, M (2017. ) Enhanced MAPK signaling is essential for CSF3R-induced leukemia.Leukemia, , 31 (8 ) ,1770-1778

Kesarwani, M; Huber, E; Azam, M (2013. ) Overcoming AC220 resistance of FLT3-ITD by SAR302503.Blood cancer journal, , 3 ,e138

Azam, M; Kesarwani, M; Natarajan, K; Datta, A (2001. ) A secretion signal is present in the Collybia velutipes oxalate decarboxylase gene.Biochemical and biophysical research communications, , 289 (4 ) ,807-12

Kesarwani, M; Azam, M; Natarajan, K; Mehta, A; Datta, A (2000. ) Oxalate decarboxylase from Collybia velutipes. Molecular cloning and its overexpression to confer resistance to fungal infection in transgenic tobacco and tomato.The Journal of biological chemistry, , 275 (10 ) ,7230-8

Contact Information

Academic - Cincinnati Childrens Hospital Medical Center
3333 Burnet Avenue, ML 7013
Cincinnati  Ohio, 45229
Phone: (513) 803-1413
mohammad.azam@cchmc.org