Expert Profile: azammd | Research Directory

Education

Doctorate, JNU, New Delhi, India

Postdoctoral Fellow, Massachusetts Institute of Technology

Postdoctoral Fellow, Children’s Hospital of Boston

Publications

Peer Reviewed Publications

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad (2015. ) Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.Scientific reports, , 5 ,14538

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Azam, Mohammad (2014. ) A method for screening and validation of resistant mutations against kinase inhibitors.Journal of visualized experiments : JoVE, , (94 ) ,

Kamthan, Ayushi; Kamthan, Mohan; Azam, Mohammad; Chakraborty, Niranjan; Chakraborty, Subhra; Datta, Asis (2012. ) Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality.Scientific reports, , 2 ,951

Azam, Mohammad; Powers, John T; Einhorn, William; Huang, Wei-Sheng; Shakespeare, William C; Zhu, Xiaotian; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K; Daley, George Q (2010. ) AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance.Chemical biology & drug design, , 75 (2 ) ,223-7

Zhang, Jianming; Adrián, Francisco J; Jahnke, Wolfgang; Cowan-Jacob, Sandra W; Li, Allen G; Iacob, Roxana E; Sim, Taebo; Powers, John; Dierks, Christine; Sun, Fangxian; Guo, Gui-Rong; Ding, Qiang; Okram, Barun; Choi, Yongmun; Wojciechowski, Amy; Deng, Xianming; Liu, Guoxun; Fendrich, Gabriele; Strauss, André; Vajpai, Navratna; Grzesiek, Stephan; Tuntland, Tove; Liu, Yi; Bursulaya, Badry; Azam, Mohammad; Manley, Paul W; Engen, John R; Daley, George Q; Warmuth, Markus; Gray, Nathanael S (2010. ) Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.Nature, , 463 (7280 ) ,501-6

Huang, Wei-Sheng; Zhu, Xiaotian; Wang, Yihan; Azam, Mohammad; Wen, David; Sundaramoorthi, Raji; Thomas, R Mathew; Liu, Shuangying; Banda, Geetha; Lentini, Scott P; Das, Sasmita; Xu, Qihong; Keats, Jeff; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T; Broudy, Marc I; Russian, Karin; Daley, George Q; Iuliucci, John; Dalgarno, David C; Clackson, Tim; Sawyer, Tomi K; Shakespeare, William C (2009. ) 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.Journal of medicinal chemistry, , 52 (15 ) ,4743-56

Viswanathan, Srinivas R; Powers, John T; Einhorn, William; Hoshida, Yujin; Ng, Tony L; Toffanin, Sara; O'Sullivan, Maureen; Lu, Jun; Phillips, Letha A; Lockhart, Victoria L; Shah, Samar P; Tanwar, Pradeep S; Mermel, Craig H; Beroukhim, Rameen; Azam, Mohammad; Teixeira, Jose; Meyerson, Matthew; Hughes, Timothy P; Llovet, Josep M; Radich, Jerald; Mullighan, Charles G; Golub, Todd R; Sorensen, Poul H; Daley, George Q (2009. ) Lin28 promotes transformation and is associated with advanced human malignancies.Nature genetics, , 41 (7 ) ,843-8

Nardi, Valentina; Naveiras, Olaia; Azam, Mohammad; Daley, George Q (2009. ) ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.Blood, , 113 (16 ) ,3813-20

Azam, Mohammad; Seeliger, Markus A; Gray, Nathanael S; Kuriyan, John; Daley, George Q (2008. ) Activation of tyrosine kinases by mutation of the gatekeeper threonine.Nature structural & molecular biology, , 15 (10 ) ,1109-18

Raz, Tal; Nardi, Valentina; Azam, Mohammad; Cortes, Jorge; Daley, George Q (2007. ) Farnesyl transferase inhibitor resistance probed by target mutagenesis.Blood, , 110 (6 ) ,2102-9

Azam, Mohammad; Nardi, Valentina; Shakespeare, William C; Metcalf, Chester A; Bohacek, Regine S; Wang, Yihan; Sundaramoorthi, Raji; Sliz, Piotr; Veach, Darren R; Bornmann, William G; Clarkson, Bayard; Dalgarno, David C; Sawyer, Tomi K; Daley, George Q (2006. ) Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.Proceedings of the National Academy of Sciences of the United States of America, , 103 (24 ) ,9244-9

Weisberg, Ellen; Manley, Paul W; Breitenstein, Werner; Brüggen, Josef; Cowan-Jacob, Sandra W; Ray, Arghya; Huntly, Brian; Fabbro, Doriano; Fendrich, Gabriele; Hall-Meyers, Elizabeth; Kung, Andrew L; Mestan, Jürgen; Daley, George Q; Callahan, Linda; Catley, Laurie; Cavazza, Cara; Azam, Mohammad; Mohammed, Azam; Neuberg, Donna; Wright, Renee D; Gilliland, D Gary; Griffin, James D (2005. ) Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.Cancer cell, , 7 (2 ) ,129-41

Nardi, Valentina; Azam, Mohammad; Daley, George Q (2004. ) Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Current opinion in hematology, , 11 (1 ) ,35-43

Azam, Mohammad; Latek, Robert R; Daley, George Q (2003. ) Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell, , 112 (6 ) ,831-43

Azam, Mohammad; Raz, Tal; Nardi, Valentina; Opitz, Sarah L.; Daley, George Q. (2003. ) A screen to identify drug resistant variants to target-directed anti-cancer agents.Biological procedures online, , 5 ,204-210

Azam, Mohammad; Kesarwani, Meenu; Chakraborty, Subhra; Natarajan, Krishnamurthy; Datta, Asis (2002. ) Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes.The Biochemical journal, , 367 (Pt 1 ) ,67-75

Khanna, Richie; Chang, Seon H; Andrabi, Shaida; Azam, Mohammad; Kim, Anthony; Rivera, Alicia; Brugnara, Carlo; Low, Philip S; Liu, Shih-Chun; Chishti, Athar H (2002. ) Headpiece domain of dematin is required for the stability of the erythrocyte membrane.Proceedings of the National Academy of Sciences of the United States of America, , 99 (10 ) ,6637-42

Dwivedi, Pankaj; Chutipongtanate, Somchai; Muench, David E; Azam, Mohammad; Grimes, Harry Leighton; Greis, Kenneth D (2020. ) SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling.Proteomics. Clinical applications, , 14 (5 ) ,e1900144

Ramkissoon, Annmarie; Chaney, Katherine E; Milewski, David; Williams, Kyle B; Williams, Rory L; Choi, Kwangmin; Miller, Adam; Kalin, Tanya V; Pressey, Joseph G; Szabo, Sara; Azam, Mohammad; Largaespada, David A; Ratner, Nancy (2019. ) Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK.Clinical cancer research : an official journal of the American Association for Cancer Research, , 25 (13 ) ,4117-4127

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D (2019. ) Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors.Scientific data, , 6 (1 ) ,21

Lin, Peipei; Ren, Yanling; Yan, Xiaomei; Luo, Yingwan; Zhang, Hua; Kesarwani, Meenu; Bu, Jiachen; Zhan, Di; Zhou, Yile; Tang, Yuting; Zhu, Shuanghong; Xu, Weilai; Zhou, Xinping; Mei, Chen; Ma, Liya; Ye, Li; Hu, Chao; Azam, Mohammad; Ding, Wei; Jin, Jie; Huang, Gang; Tong, Hongyan (2019. ) The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes.Haematologica, , 104 (3 ) ,485-496

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad (2019. ) Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.Journal of visualized experiments : JoVE, , (143 ) ,

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D (2019. ) Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors.Leukemia, , 33 (1 ) ,75-87

Wang, Jieyu; Hayashi, Yoshihiro; Yokota, Asumi; Xu, Zefeng; Zhang, Yue; Huang, Rui; Yan, Xiaomei; Liu, Hongyun; Ma, Liping; Azam, Mohammad; Bridges, James P; Cancelas, Jose A; Kalfa, Theodosia A; An, Xiuli; Xiao, Zhijian; Huang, Gang (2018. ) Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.Haematologica, , 103 (1 ) ,40-50

Cui, Pei-Pei; Zhang, Xiu-Du; Wang, Peng; Zhao, Yue; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin (2017. ) Zinc(II) and Copper(II) Hybrid Frameworks via Metal-Ion Metathesis with Enhanced Gas Uptake and Photoluminescence Properties.Inorganic chemistry, , 56 (22 ) ,14157-14163

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad (2017. ) MEK/ERK addiction in CNL/aCML.Oncotarget, , 8 (59 ) ,99215-99216

Azam, Mohammad; Al-Resayes, Saud I; Soliman, Saied M; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Khan, Zahid (2017. ) A (salicylaldiminato)Pt(II) complex with dimethylpropylene linkage: Synthesis, structural characterization and antineoplastic activity.Journal of photochemistry and photobiology. B, Biology, , 176 ,150-156

Liu, Zhi-Qiang; Zhao, Yue; Zhang, Xiu-Du; Kang, Yan-Shang; Lu, Qing-Yi; Azam, Mohammad; Al-Resayes, Saud I; Sun, Wei-Yin (2017. ) Metal-organic frameworks with 1,4-di(1H-imidazol-4-yl)benzene and varied carboxylate ligands for selectively sensing Fe(iii) ions and ketone molecules.Dalton transactions (Cambridge, England : 2003), , 46 (40 ) ,13943-13951

Wang, Peng; Chen, Kai; Liu, Qing; Wang, Huai-Wei; Azam, Mohammad; Al-Resayes, Saud I; Lu, Yi; Sun, Wei-Yin (2017. ) Fine tuning of catalytic and sorption properties of metal-organic frameworks via in situ ligand exchange.Dalton transactions (Cambridge, England : 2003), , 46 (34 ) ,11425-11430

Liu, Zhi-Qiang; Zhao, Yue; Wang, Peng; Kang, Yan-Shang; Azam, Mohammad; Al-Resayes, Saud I; Liu, Xiao-Hui; Lu, Qing-Yi; Sun, Wei-Yin (2017. ) Fluorescent sensing and selective adsorption properties of metal-organic frameworks with mixed tricarboxylate and 1H-imidazol-4-yl-containing ligands.Dalton transactions (Cambridge, England : 2003), , 46 (28 ) ,9022-9029

Kesarwani, Meenu; Kincaid, Zachary; Gomaa, Ahmed; Huber, Erika; Rohrabaugh, Sara; Siddiqui, Zain; Bouso, Muhammad F; Latif, Tahir; Xu, Ming; Komurov, Kakajan; Mulloy, James C; Cancelas, Jose A; Grimes, H Leighton; Azam, Mohammad (2017. ) Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.Nature medicine, , 23 (4 ) ,472-482

Zhang, Xin; Jia, Deyong; Ao, Junping; Liu, Huijuan; Zang, Yi; Azam, Mohammad; Habib, Samy L; Li, Jia; Ruan, Xinsen; Jia, Hao; Wang, Xueying; Li, Baojie (2016. ) Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia.Oncotarget, , 7 (43 ) ,69945-69960

Azam, Mohammad; Velmurugan, Gunasekaran; Wabaidur, Saikh Mohammad; Trzesowska-Kruszynska, Agata; Kruszynski, Rafal; Al-Resayes, Saud I; Al-Othman, Zeid A; Venuvanalingam, Ponnambalam (2016. ) Structural elucidation and physicochemical properties of mononuclear Uranyl(VI) complexes incorporating dianionic units.Scientific reports, , 6 ,32898

Azam, Mohammad Nurul; Shahjahan, Mohammad; Yeasmin, Mahbuba; Ahmed, Nasar U (2016. ) Prevalence of Smokeless Tobacco among Low Socioeconomic Populations: A Cross-Sectional Analysis.PloS one, , 11 (6 ) ,e0156887

Sallam, Mowaffaq Awad; Sheikh, Kamaludin Ahmed; Baxendale, Ronald; Azam, Mohammad Nurul; El-Setouhy, Maged (2016. ) The physiological and perceptual effects of plant extracts (Catha Edulis Forsk) during sustained exercise.Substance abuse treatment, prevention, and policy, , 11 (1 ) ,18

Dwivedi, Pankaj; Chutipongtanate, Somchai; Muench, David E; Azam, Mohammad; Grimes, Harry Leighton; Greis, Kenneth D (2020. ) SWATH-Proteomics of Ibrutinib's Action in Myeloid Leukemia Initiating Mutated G-CSFR Signaling.Proteomics. Clinical applications, , 14 (5 ) ,e1900144

Ramkissoon, Annmarie; Chaney, Katherine E; Milewski, David; Williams, Kyle B; Williams, Rory L; Choi, Kwangmin; Miller, Adam; Kalin, Tanya V; Pressey, Joseph G; Szabo, Sara; Azam, Mohammad; Largaespada, David A; Ratner, Nancy (2019. ) Targeted Inhibition of the Dual Specificity Phosphatases DUSP1 and DUSP6 Suppress MPNST Growth via JNK.Clinical cancer research : an official journal of the American Association for Cancer Research, , 25 (13 ) ,4117-4127

Lin, Peipei; Ren, Yanling; Yan, Xiaomei; Luo, Yingwan; Zhang, Hua; Kesarwani, Meenu; Bu, Jiachen; Zhan, Di; Zhou, Yile; Tang, Yuting; Zhu, Shuanghong; Xu, Weilai; Zhou, Xinping; Mei, Chen; Ma, Liya; Ye, Li; Hu, Chao; Azam, Mohammad; Ding, Wei; Jin, Jie; Huang, Gang; Tong, Hongyan (2019. ) The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes.Haematologica, , 104 (3 ) ,485-496

Kesarwani, Meenu; Kincaid, Zachary; Azam, Mohammad (2019. ) Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.Journal of visualized experiments : JoVE, , (143 ) ,

Dwivedi, Pankaj; Muench, David E; Wagner, Michael; Azam, Mohammad; Grimes, H Leighton; Greis, Kenneth D (2019. ) Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors.Leukemia, , 33 (1 ) ,75-87

Azam, Mohammad; Al-Resayes, Saud I; Wabaidur, Saikh Mohammad; Altaf, Mohammad; Chaurasia, Bhaskar; Alam, Mahboob; Shukla, Satyendra Nath; Gaur, Pratiksha; Albaqami, Nader Talmas M; Islam, Mohammad Shahidul; Park, Soonheum (2018. ) Synthesis, Structural Characterization and Antimicrobial Activity of Cu(II) and Fe(III) Complexes Incorporating Azo-Azomethine Ligand.Molecules (Basel, Switzerland), , 23 (4 ) ,

Sallam, Mowaffaq Awad; Sheikh, Kamaludin Ahmed; Baxendale, Ronald; Azam, Mohammad Nurul; Hossain, Anwar M; El-Setouhy, Maged (2018. ) The Physiological and Ergogenic Effects of Khat (Catha edulis Forsk) Extract.Substance use & misuse, , 53 (1 ) ,94-100