Mohammad Azam

Assistant Professor

Medical Sciences Building

COM Pathology & Lab Medicine - 0529

Cincinnati Childrens Hospital Medical Center
3333 Burnet Avenue, ML 7013
Cincinnati, Ohio 45229

Education

Doctorate, JNU, New Delhi, India

Postdoctoral Fellow, Massachusetts Institute of Technology

Postdoctoral Fellow, Children’s Hospital of Boston

Publications

Peer Reviewed Publications

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad (2015. )Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance.Scientific reports, ,5 ,14538

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Azam, Mohammad (2014. )A method for screening and validation of resistant mutations against kinase inhibitors.Journal of visualized experiments : JoVE, ,(94 ),

Kamthan, Ayushi; Kamthan, Mohan; Azam, Mohammad; Chakraborty, Niranjan; Chakraborty, Subhra; Datta, Asis (2012. )Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality.Scientific reports, ,2 ,951

Azam, Mohammad; Powers, John T; Einhorn, William; Huang, Wei-Sheng; Shakespeare, William C; Zhu, Xiaotian; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K; Daley, George Q (2010. )AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance.Chemical biology & drug design, ,75 (2 ),223-7

Zhang, Jianming; Adrián, Francisco J; Jahnke, Wolfgang; Cowan-Jacob, Sandra W; Li, Allen G; Iacob, Roxana E; Sim, Taebo; Powers, John; Dierks, Christine; Sun, Fangxian; Guo, Gui-Rong; Ding, Qiang; Okram, Barun; Choi, Yongmun; Wojciechowski, Amy; Deng, Xianming; Liu, Guoxun; Fendrich, Gabriele; Strauss, André; Vajpai, Navratna; Grzesiek, Stephan; Tuntland, Tove; Liu, Yi; Bursulaya, Badry; Azam, Mohammad; Manley, Paul W; Engen, John R; Daley, George Q; Warmuth, Markus; Gray, Nathanael S (2010. )Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.Nature, ,463 (7280 ),501-6

Huang, Wei-Sheng; Zhu, Xiaotian; Wang, Yihan; Azam, Mohammad; Wen, David; Sundaramoorthi, Raji; Thomas, R Mathew; Liu, Shuangying; Banda, Geetha; Lentini, Scott P; Das, Sasmita; Xu, Qihong; Keats, Jeff; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T; Broudy, Marc I; Russian, Karin; Daley, George Q; Iuliucci, John; Dalgarno, David C; Clackson, Tim; Sawyer, Tomi K; Shakespeare, William C (2009. )9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.Journal of medicinal chemistry, ,52 (15 ),4743-56

Viswanathan, Srinivas R; Powers, John T; Einhorn, William; Hoshida, Yujin; Ng, Tony L; Toffanin, Sara; O'Sullivan, Maureen; Lu, Jun; Phillips, Letha A; Lockhart, Victoria L; Shah, Samar P; Tanwar, Pradeep S; Mermel, Craig H; Beroukhim, Rameen; Azam, Mohammad; Teixeira, Jose; Meyerson, Matthew; Hughes, Timothy P; Llovet, Josep M; Radich, Jerald; Mullighan, Charles G; Golub, Todd R; Sorensen, Poul H; Daley, George Q (2009. )Lin28 promotes transformation and is associated with advanced human malignancies.Nature genetics, ,41 (7 ),843-8

Nardi, Valentina; Naveiras, Olaia; Azam, Mohammad; Daley, George Q (2009. )ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines.Blood, ,113 (16 ),3813-20

Azam, Mohammad; Seeliger, Markus A; Gray, Nathanael S; Kuriyan, John; Daley, George Q (2008. )Activation of tyrosine kinases by mutation of the gatekeeper threonine.Nature structural & molecular biology, ,15 (10 ),1109-18

Raz, Tal; Nardi, Valentina; Azam, Mohammad; Cortes, Jorge; Daley, George Q (2007. )Farnesyl transferase inhibitor resistance probed by target mutagenesis.Blood, ,110 (6 ),2102-9

Azam, Mohammad; Nardi, Valentina; Shakespeare, William C; Metcalf, Chester A; Bohacek, Regine S; Wang, Yihan; Sundaramoorthi, Raji; Sliz, Piotr; Veach, Darren R; Bornmann, William G; Clarkson, Bayard; Dalgarno, David C; Sawyer, Tomi K; Daley, George Q (2006. )Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance.Proceedings of the National Academy of Sciences of the United States of America, ,103 (24 ),9244-9

Weisberg, Ellen; Manley, Paul W; Breitenstein, Werner; Brüggen, Josef; Cowan-Jacob, Sandra W; Ray, Arghya; Huntly, Brian; Fabbro, Doriano; Fendrich, Gabriele; Hall-Meyers, Elizabeth; Kung, Andrew L; Mestan, Jürgen; Daley, George Q; Callahan, Linda; Catley, Laurie; Cavazza, Cara; Azam, Mohammad; Mohammed, Azam; Neuberg, Donna; Wright, Renee D; Gilliland, D Gary; Griffin, James D (2005. )Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.Cancer cell, ,7 (2 ),129-41

Nardi, Valentina; Azam, Mohammad; Daley, George Q (2004. )Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Current opinion in hematology, ,11 (1 ),35-43

Azam, Mohammad; Latek, Robert R; Daley, George Q (2003. )Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell, ,112 (6 ),831-43

Azam, Mohammad; Raz, Tal; Nardi, Valentina; Opitz, Sarah L.; Daley, George Q. (2003. )A screen to identify drug resistant variants to target-directed anti-cancer agents.Biological procedures online, ,5 ,204-210

Azam, Mohammad; Kesarwani, Meenu; Chakraborty, Subhra; Natarajan, Krishnamurthy; Datta, Asis (2002. )Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes.The Biochemical journal, ,367 (Pt 1 ),67-75

Khanna, Richie; Chang, Seon H; Andrabi, Shaida; Azam, Mohammad; Kim, Anthony; Rivera, Alicia; Brugnara, Carlo; Low, Philip S; Liu, Shih-Chun; Chishti, Athar H (2002. )Headpiece domain of dematin is required for the stability of the erythrocyte membrane.Proceedings of the National Academy of Sciences of the United States of America, ,99 (10 ),6637-42

Contact Information

Academic - Cincinnati Childrens Hospital Medical Center
3333 Burnet Avenue, ML 7013
Cincinnati  Ohio, 45229
Phone: (513) 803-1413
mohammad.azam@cchmc.org