George Babcock

George F. Babcock


Shriner's Burn Institute


COM Surgery Research - 0558

Shriners Hospitals for Children - Cincinnati
Room 446
Cincinnati, Ohio 45229


Bachelor's Degree, Muskingum College 1970 (Biology)

Master's Degree, North Dakota State University 1972

Doctoral Degree, University of Nebraska Medical Center 1975 (Medical Microbiology and Immunology)

Postdoctoral Training, University of North Carolina 1978 (Microbiology and Immunology)

Research and Practice Interests

Immunology of Burns, Trauma and Infectious Disease

Research Support

Grant: #SRS 002562 Investigators:Babcock, George 03-19-2007 -03-19-2012 Naval Health Research Center Navy Education Partnership Role:PI $.00 Active Level:Federal

Investigators:Babcock, George 08-01-2003 -07-31-2005 Thrasher Research Fund The Reduction of Infections in Seriously Burned Patients Role:PI $174,836.00 Closed Level:Private Non-Profit

Grant: #07-W911QY-08-P-0469 Investigators:Babcock, George 07-17-2008 -07-16-2009 Naval Health Research Center the Short and Long Term Immunological Response and Long Term Genotoxic Effects of Using Tungsten in Military Munitions Role:PI $80,393.00 Closed Level:Federal

Grant: #W911QY-08-P-0779 Investigators:Babcock, George 09-19-2008 -12-31-2009 Department of the Navy The Effects of Ingestion of Iraqi Particulate Matter on the Intestine and Immune System Role:PI $83,790.00 Closed Level:Federal

Grant: #1006754 Investigators:Babcock, George; Dugan, Amy; Horseman, Nelson 01-01-2009 -12-31-2009 Shriners Hospitals for Children - Cincinnati Shrine Physiology 2009 Consulting Agreements Role:Collaborator $175,036.00 Closed Level:Private Non-Profit

Grant: #W911QY-09-P-0706 Investigators:Babcock, George 09-29-2009 -09-28-2010 Office of Naval Research Effects of Environmental Toxins For Burn Injuries and Severe Trauma Role:PI $80,000.00 Active Level:Federal

Grant: #W911QY-10-C-0103 Investigators:Babcock, George 05-03-2010 -11-30-2011 Naval Health Research Center The Effects of Short-Term Exposure to Tungsten on the Immune Response Role:PI $159,963.00 Closed Level:Federal

Grant: #R21 EY021768 Investigators:Babcock, George; Kao, Winston Whei Yang; Liu, Hongshan 09-30-2011 -08-31-2015 National Eye Institute Cell Therapy of Corneal Diseases with Umbilical Mesenchyme Stem Cells Role:Collaborator $1,705,844.00 Active Level:Federal

Grant: #Prime W81XWH-11-2-0233-P00001 Investigators:Babcock, George; Healy, Daniel 09-30-2011 -03-30-2013 Department of the Army Medical Research Acquisition Activity The use of TheraGauze in the Treatment of Burn Wounds Role:PI $163,595.00 Active Level:Federal

Grant: #Prime W81XWH-11-2-0233-P00001 Investigators:Babcock, George; Healy, Daniel 09-30-2011 -03-30-2013 Department of the Army Medical Research Acquisition Activity The use of TheraGauze in the Treatment of Burn Wounds Role:PI $163,595.00 Closed Level:Federal

Grant: #LP- NCRADA-NMRC-15-9713 Investigators:Babcock, George 03-17-2016 -03-16-2017 Department of the Navy A Limited Purpose Coorperative Research and Development Agreement For Material Transfer Role:PI $.00 Active Level:Federal

Grant: #DoD1-SA1 / W81XWH-15-2-0065 Investigators:Babcock, George; Lentsch, Alex 01-01-2017 -12-31-2017 Department of the Army Medical Research Acquisition Activity Antimicrobial block copolypeptides (A-Blocks): Innovative Therapeutics and Prophylacics for Wound Infection Role:PI $517,802.00 Awarded Level:Federal

Grant: #AMIC-AW1 Investigators:Babcock, George 07-01-2018 -12-31-2018 Amicrobe, Inc. Antimicrobial block copolypeptides (A-Blocks): Innovative Therapeutics and Prophylacics for Wound Infection Role:PI $130,000.00 Active Level:Industry

Grant: #2019 Research Agreement Investigators:Babcock, George 01-01-2019 -03-31-2019 Rem Brands, Inc. Efficacy Study of a Test Compound in a Murine Infection Model Role:PI $45,496.00 Active Level:Industry


Peer Reviewed Publications

Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F (2013. ) Concerns over interspecies transcriptional comparisons in mice and humans after trauma.Proceedings of the National Academy of Sciences of the United States of America, , 110 (36 ) ,E3370

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A (2012. ) Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3.The Journal of investigative dermatology, , 132 (9 ) ,2255-62

Tichy, Elisia D; Pillai, Resmi; Deng, Li; Tischfield, Jay A; Hexley, Philip; Babcock, George F; Stambrook, Peter J (2012. ) The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels.Stem cell research, , 9 (2 ) ,124-34

Hexley, Philip; Robinson, Chad T; Osterburg, Andrew R; Babcock, George F (2012. ) Circulating microparticles do not all share biophysical light scatter properties with immune complexes when analyzed by flow cytometry.Blood, , 120 (7 ) ,1528-9

Babcock, George F; Hernandez, Laura; Yadav, Ekta; Schwemberger, Sandy; Dugan, Amy (2012. ) The burn wound inflammatory response is influenced by midazolam.Inflammation, , 35 (1 ) ,259-70

Kavanaugh, Gina M; Wise-Draper, Trisha M; Morreale, Richard J; Morrison, Monique A; Gole, Boris; Schwemberger, Sandy; Tichy, Elisia D; Lu, Lu; Babcock, George F; Wells, James M; Drissi, Rachid; Bissler, John J; Stambrook, Peter J; Andreassen, Paul R; Wiesmüller, Lisa; Wells, Susanne I (2011. ) The human DEK oncogene regulates DNA damage response signaling and repair.Nucleic acids research, , 39 (17 ) ,7465-76

Tichy, Elisia D; Pillai, Resmi; Deng, Li; Liang, Li; Tischfield, Jay; Schwemberger, Sandy J; Babcock, George F; Stambrook, Peter J (2010. ) Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks.Stem cells and development, , 19 (11 ) ,1699-711

Jacobson, Eric M; Yang, Heyi; Menconi, Francesca; Wang, Rong; Osman, Roman; Skrabanek, Luce; Li, Cheuk Wun; Fadlalla, Mohammed; Gandhi, Alisha; Chaturvedi, Vijaya; Smith, Eric P; Schwemberger, Sandy; Osterburg, Andrew; Babcock, George F; Tomer, Yaron (2009. ) Employing a recombinant HLA-DR3 expression system to dissect major histocompatibility complex II-thyroglobulin peptide dynamism: a genetic, biochemical, and reverse immunological perspective.The Journal of biological chemistry, , 284 (49 ) ,34231-43

Bommireddy, R; Bueno, O F; Martin, J; Ormsby, I; Chen, H; Gard, C; Molkentin, J D; Boivin, G P; Babcock, G F; Doetschman, T (2009. ) Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice.Clinical and experimental immunology, , 158 (3 ) ,317-24

Azhar, Mohamad; Yin, Moying; Bommireddy, Ramireddy; Duffy, John J; Yang, Junqi; Pawlowski, Sharon A; Boivin, Gregory P; Engle, Sandra J; Sanford, L P; Grisham, Christina; Singh, Ram R; Babcock, George F; Doetschman, Thomas (2009. ) Generation of mice with a conditional allele for transforming growth factor beta 1 gene.Genesis (New York, N.Y. : 2000), , 47 (6 ) ,423-31

Fumagalli, Stefano; Di Cara, Alessandro; Neb-Gulati, Arti; Natt, Francois; Schwemberger, Sandy; Hall, Jonathan; Babcock, George F; Bernardi, Rosa; Pandolfi, Pier Paolo; Thomas, George (2009. ) Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.Nature cell biology, , 11 (4 ) ,501-8

Bommireddy, Ramireddy; Babcock, George F; Singh, Ram R; Doetschman, Thomas (2008. ) TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function.Clinical immunology (Orlando, Fla.), , 127 (2 ) ,206-13

Caldwell, Julie M; Chen, Yinhuai; Schollaert, Kaila L; Theis, James F; Babcock, George F; Newlon, Carol S; Sanchez, Yolanda (2008. ) Orchestration of the S-phase and DNA damage checkpoint pathways by replication forks from early origins.The Journal of cell biology, , 180 (6 ) ,1073-86

Markey, M P; Bergseid, J; Bosco, E E; Stengel, K; Xu, H; Mayhew, C N; Schwemberger, S J; Braden, W A; Jiang, Y; Babcock, G F; Jegga, A G; Aronow, B J; Reed, M F; Wang, J Y J; Knudsen, E S (2007. ) Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.Oncogene, , 26 (43 ) ,6307-18

Dugan, Amy L; Schwemberger, Sandy; Noel, Greg J; Babcock, George F; Ogle, Cora K; Buckley, Donna J; Horseman, Nelson D; Gregerson, Karen A (2007. ) Stress and prolactin effects on bone marrow myeloid cells, serum chemokine and serum glucocorticoid levels in mice.Neuroimmunomodulation, , 14 (6 ) ,287-96

Wetherill, Yelena B; Hess-Wilson, Janet K; Comstock, Clay E S; Shah, Supriya A; Buncher, C Ralph; Sallans, Larry; Limbach, Patrick A; Schwemberger, Sandy; Babcock, George F; Knudsen, Karen E (2006. ) Bisphenol A facilitates bypass of androgen ablation therapy in prostate cancer.Molecular cancer therapeutics, , 5 (12 ) ,3181-90

Bommireddy, Ramireddy; Pathak, Leena J; Martin, Jennifer; Ormsby, Ilona; Engle, Sandra J; Boivin, Gregory P; Babcock, George F; Eriksson, Anna U; Singh, Ram R; Doetschman, Thomas (2006. ) Self-antigen recognition by TGF beta1-deficient T cells causes their activation and systemic inflammation.Laboratory investigation; a journal of technical methods and pathology, , 86 (10 ) ,1008-19

Mayhew, Christopher N; Bosco, Emily E; Fox, Sejal R; Okaya, Tomohisa; Tarapore, Pheruza; Schwemberger, Sandy J; Babcock, George F; Lentsch, Alex B; Fukasawa, Kenji; Knudsen, Erik S (2005. ) Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy.Cancer research, , 65 (11 ) ,4568-77

Keshavan, Pavitra; Deem, Tracy L; Schwemberger, Sandy J; Babcock, George F; Cook-Mills, Joan M; Zucker, Stephen D (2005. ) Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration. Journal of immunology (Baltimore, Md. : 1950), , 174 (6 ) ,3709-18

Keshavan, Pavitra; Schwemberger, Sandy J; Smith, Darcey L H; Babcock, George F; Zucker, Stephen D (2004. ) Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization.International journal of cancer, , 112 (3 ) ,433-45

Babcock, George F (2004. ) Common problems encountered by IACUCs--one chair's perspective. Contemporary topics in laboratory animal science, , 43 (3 ) ,70-1

Babcock, George F (2004. ) Intracellular cytokines.Current protocols in cytometry, , Chapter 9 ,Unit 9.9

Dugan, Amy L; Schwemberger, Sandy; Babcock, George F; Buckley, Donna; Buckley, Arthur R; Ogle, Cora K; Horseman, Nelson D (2004. ) Effects of prolactin level on burn-induced aberrations in myelopoiesis.Shock (Augusta, Ga.), , 21 (2 ) ,151-9

Babcock, George F (2003. ) Predictive medicine: severe trauma and burns.Cytometry. Part B, Clinical cytometry, , 53 (1 ) ,48-53

Bommireddy, Ramireddy; Saxena, Vijay; Ormsby, Ilona; Yin, Moying; Boivin, Gregory P; Babcock, George F; Singh, Ram R; Doetschman, Thomas (2003. ) TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. Journal of immunology (Baltimore, Md. : 1950), , 170 (9 ) ,4612-22

Bommireddy, Ramireddy; Ormsby, Ilona; Yin, Moying; Boivin, Gregory P; Babcock, George F; Doetschman, Thomas (2003. ) TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. Journal of immunology (Baltimore, Md. : 1950), , 170 (7 ) ,3645-52

Heinen, Christopher D; Goss, Kathleen Heppner; Cornelius, James R; Babcock, George F; Knudsen, Erik S; Kowalik, Timothy; Groden, Joanna (2002. ) The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Gastroenterology, , 123 (3 ) ,751-63

Gibson, S W; Valente, J F; Alexander, J W; Custer, D A; Li, B G; Frede, S; Babcock, G F; Ogle, C K (2000. ) Nutritional immunomodulation leads to enhanced allograft survival in combination with cyclosporine A and rapamycin, but not FK506. Transplantation, , 69 (10 ) ,2034-8

Le Poole, I C; Yang, F; Brown, T L; Cornelius, J; Babcock, G F; Das, P K; Boissy, R E (1999. ) Altered gene expression in melanocytes exposed to 4-tertiary butyl phenol (4-TBP): upregulation of the A2b adenosine receptor 1.The Journal of investigative dermatology, , 113 (5 ) ,725-31

Rodeberg, D A; Meyer, J G; Babcock, G F (1999. ) Heat shock response: presence and effects in burn patient neutrophils. Journal of leukocyte biology, , 66 (5 ) ,773-80

Jawa, R S; Quaid, G A; Williams, M A; Cave, C M; Robinson, C T; Babcock, G F; Lieberman, M A; Witt, D; Solomkin, J S (1999. ) Tumor necrosis factor alpha regulates CXC chemokine receptor expression and function. Shock (Augusta, Ga.), , 11 (6 ) ,385-90

Gibson, S W; Valente, J F; Alexander, J W; Custer, D A; Babcock, G F; Ogle, C K (1999. ) The effect of nutritional immunomodulation on cardiac allograft survival in rats receiving mycophenolate mofetil, cyclosporine A, and donor-specific transfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, , 18 (3 ) ,185-9

Babcock, G F (1999. ) Quantitation of phagocytosis by confocal microscopy. Methods in enzymology, , 307 ,319-28

King, K L; Moreira, K M; Babcock, G F; Wang, J; Campos, B; Kaetzel, M A; Dedman, J R (1998. ) Temporal inhibition of calmodulin in the nucleus. Biochimica et biophysica acta, , 1448 (2 ) ,245-53

Alexander, J W; Valente, J F; Greenberg, N A; Custer, D A; Ogle, C K; Gibson, S W; Babcock, G F (1998. ) Dietary omega-3 and omega-9 fatty acids uniquely enhance allograft survival in cyclosporine-treated and donor-specific transfusion-treated rats. Transplantation, , 65 (10 ) ,1304-9

Rodeberg, D A; Morris, R E; Babcock, G F (1997. ) Azurophilic granules of human neutrophils contain CD14. Infection and immunity, , 65 (11 ) ,4747-53

Swope, V B; Supp, A P; Cornelius, J R; Babcock, G F; Boyce, S T (1997. ) Regulation of pigmentation in cultured skin substitutes by cytometric sorting of melanocytes and keratinocytes. The Journal of investigative dermatology, , 109 (3 ) ,289-95

Levy, A E; Alexander, J W; Babcock, G F (1997. ) A strategy for generating consistent long-term donor-specific tolerance to solid organ allografts. Transplant immunology, , 5 (2 ) ,83-8

Rodeberg, D A; Bass, R C; Alexander, J W; Warden, G D; Babcock, G F (1997. ) Neutrophils from burn patients are unable to increase the expression of CD11b/CD18 in response to inflammatory stimuli. Journal of leukocyte biology, , 61 (5 ) ,575-82

Hess, K L; Babcock, G F; Askew, D S; Cook-Mills, J M (1997. ) A novel flow cytometric method for quantifying phagocytosis of apoptotic cells. Cytometry, , 27 (2 ) ,145-52

Goggins, W C; Fisher, R A; Dattilo, J B; Cohen, D S; Tawes, J W; Dattilo, M P; Babcock, G F; Frede, S E; Wakely, P E; Posner, M P (1997. ) Analysis of functional renal allograft tolerance with single-dose rapamycin based induction immunosuppression. Transplantation, , 63 (2 ) ,310-4

Frede, S E; Levy, A E; Alexander, J W; Babcock, G F (1996. ) An examination of tissue chimerism in the ACI to Lewis rat cardiac transplant model. Transplant immunology, , 4 (3 ) ,227-31

Gennari, R; Alexander, J W; Boyce, S T; Lilly, N; Babcock, G F; Cornaggia, M (1996. ) Effects of the angiotensin converting enzyme inhibitor enalapril on bacterial translocation after thermal injury and bacterial challenge. Shock (Augusta, Ga.), , 6 (2 ) ,95-100

Kane, T D; Johnson, S R; Alexander, J W; Babcock, G F; Ogle, C K (1996. ) Detection of intestinal bacterial translocation using PCR.The Journal of surgical research, , 63 (1 ) ,59-63

Babcock, G F; Alexander, J W (1996. ) The effects of blood transfusion on cytokine production by TH1 and TH2 lymphocytes in the mouse. Transplantation, , 61 (3 ) ,465-8

Peck, M D; Babcock, G F; Alexander, J W; Billiar, T; Ochoa, J (1995. ) High doses of dietary arginine during repletion impair weight gain and increase infectious mortality in protein-malnourished mice. The British journal of nutrition, , 74 (6 ) ,787-95

Gennari, R; Alexander, J W; Eaves-Pyles, T; Babcock, G F (1994. ) Heparan sulfate increases survival during gut-derived sepsis by decreasing bacterial translocation and enhancing host defense. Shock (Augusta, Ga.), , 2 (4 ) ,246-50

Swope, V B; Sauder, D N; McKenzie, R C; Sramkoski, R M; Krug, K A; Babcock, G F; Nordlund, J J; Abdel-Malek, Z A (1994. ) Synthesis of interleukin-1 alpha and beta by normal human melanocytes. The Journal of investigative dermatology, , 102 (5 ) ,749-53

Solomkin, J S; Bass, R C; Bjornson, H S; Tindal, C J; Babcock, G F (1994. ) Alterations of neutrophil responses to tumor necrosis factor alpha and interleukin-8 following human endotoxemia. Infection and immunity, , 62 (3 ) ,943-7

Babcock, G F; Dawes, S M (1994. ) Immunophenotyping using fixed cells. Methods in cell biology, , 41 ,81-93

De Stefano, J A; Foy, J M; Sullivan, D W; Dawes, S M; Cushion, M T; Babcock, G F; Sleight, R G; van Halbeek, H; Walzer, P D (1994. ) Fractionation of Pneumocystis carinii developmental stages by counterflow centrifugal elutriation and sequential filtrations. Parasitology research, , 80 (1 ) ,1-9

Gianotti, L; Munda, R; Alexander, J W; Tchervenkov, J I; Babcock, G F (1993. ) Bacterial translocation: a potential source for infection in acute pancreatitis. Pancreas, , 8 (5 ) ,551-8

Gianotti, L; Alexander, J W; Pyles, T; Fukushima, R; Babcock, G F (1993. ) Prostaglandin E1 analogues misoprostol and enisoprost decrease microbial translocation and modulate the immune response. Circulatory shock, , 40 (4 ) ,243-9

Wolos, J A; Frondorf, K A; Babcock, G F; Stripp, S A; Bowlin, T L (1993. ) Immunomodulation by an inhibitor of S-adenosyl-L-homocysteine hydrolase: inhibition of in vitro and in vivo allogeneic responses.Cellular immunology, , 149 (2 ) ,402-8

White-Owen, C; Hartmann, S; Alexander, J W; Babcock, G F (1993. ) Reduced PMN beta 2 integrins after trauma: a possible role for colony-stimulating factors. Clinical and experimental immunology, , 92 (3 ) ,477-81

Gianotti, L; Pyles, T; Alexander, J W; Fukushima, R; Babcock, G F (1993. ) Identification of the blood component responsible for increased susceptibility to gut-derived infection. Transfusion, , 33 (6 ) ,458-65

White-Owen, C; Alexander, J W; Sramkoski, R M; Babcock, G F (1992. ) Rapid whole-blood microassay using flow cytometry for measuring neutrophil phagocytosis. Journal of clinical microbiology, , 30 (8 ) ,2071-6

Gianotti, L; Pyles, T; Alexander, J W; Babcock, G F; Carey, M A (1992. ) Impact of blood transfusion and burn injury on microbial translocation and bacterial survival. Transfusion, , 32 (4 ) ,312-7

Alexander, J W; Babcock, G F; First, M R; Davies, C B; Madden, R L; Munda, R; Penn, I; Fidler, J P; Cofer, B R; Stephens, G (1992. ) The induction of immunologic hyporesponsiveness by preoperative donor-specific transfusions and cyclosporine in human cadaveric transplants. A preliminary trial. Transplantation, , 53 (2 ) ,423-7

De Stefano, J A; Sleight, R G; Babcock, G F; Sramkoski, R M; Walzer, P D (1992. ) Isolation of Pneumocystis carinii cysts by flow cytometry. Parasitology research, , 78 (3 ) ,179-82

Alexander, J W; Gianotti, L; Pyles, T; Carey, M A; Babcock, G F (1991. ) Distribution and survival of Escherichia coli translocating from the intestine after thermal injury. Annals of surgery, , 213 (6 ) ,558-66; discussion 5

Amoscato, A A; Sramkoski, R M; Babcock, G F; Alexander, J W (1990. ) Neutral surface aminopeptidase activity of human tumor cell lines. Biochimica et biophysica acta, , 1041 (3 ) ,317-9

Alexander, J W; Boyce, S T; Babcock, G F; Gianotti, L; Peck, M D; Dunn, D L; Pyles, T; Childress, C P; Ash, S K (1990. ) The process of microbial translocation. Annals of surgery, , 212 (4 ) ,496-510; discussion

Sasamoto, Y; Alexander, J W; Babcock, G F Prolonged survival of reconstituted skin grafts without immunosuppression. The Journal of burn care & rehabilitation, , 11 (3 ) ,190-200

Fang, C H; Peck, M D; Alexander, J W; Babcock, G F; Warden, G D (1990. ) The effect of free radical scavengers on outcome after infection in burned mice. The Journal of trauma, , 30 (4 ) ,453-6

Peck, M D; Alexander, J W; Ogle, C K; Babcock, G F (1990. ) The effect of dietary fatty acids on response to Pseudomonas infection in burned mice. The Journal of trauma, , 30 (4 ) ,445-52

Babcock, G F; Alexander, J W; Warden, G D (1990. ) Flow cytometric analysis of neutrophil subsets in thermally injured patients developing infection. Clinical immunology and immunopathology, , 54 (1 ) ,117-25

Perez, R V; Babcock, G F; Alexander, J W (1989. ) Immunoregulation of transfusion-induced immunosuppression with inhibitors of the arachidonic acid metabolism. Transplantation, , 48 (1 ) ,85-7

Amoscato, A A; Alexander, J W; Babcock, G F (1989. ) Surface aminopeptidase activity of human lymphocytes. I. Biochemical and biologic properties of intact cells. Journal of immunology (Baltimore, Md. : 1950), , 142 (4 ) ,1245-52

Babcock, G F; Smith, L A; Alexander, J W (1988. ) A comparison of single and multiple blood transfusions in the mixed lymphocyte response of rats. Transplantation proceedings, , 20 (6 ) ,1213-6

Amoscato, A A; Balasubramaniam, A; Alexander, J W; Babcock, G F (1988. ) Degradation of thymopentin by human lymphocytes: evidence for aminopeptidase activity. Biochimica et biophysica acta, , 955 (2 ) ,164-74

Zhao, X F; Schroeder, T J; Alexander, J W; Miskell, P; Gonce, S J; Babcock, G F (1988. ) The prolongation of skin allograft survival by topical use of cyclosporine A. Transplantation proceedings, , 20 (2 Suppl 2 ) ,670-3

Babcock, G F (1988. ) Workshop on flow cytometry methodologies. Cytometry. Supplement : the journal of the Society for Analytical Cytology, , 3 ,106-7

Lai, C S; Wesseler, T A; Alexander, J W; Babcock, G F (1987. ) Long-term survival of skin allografts in rats treated with topical cyclosporine. Transplantation, , 44 (1 ) ,83-7

Bowlin, T L; McKown, B J; Babcock, G F; Sunkara, P S (1987. ) Intracellular polyamine biosynthesis is required for interleukin 2 responsiveness during lymphocyte mitogenesis. Cellular immunology, , 106 (2 ) ,420-7

Babcock, G F; Taylor, A F; Hynd, B A; Sramkoski, R M; Alexander, J W (1987. ) Flow cytometric analysis of lymphocyte subset phenotypes comparing normal children and adults. Diagnostic and clinical immunology, , 5 (4 ) ,175-9

Banks, R A; Nishioka, K; Kazazi, F; Babcock, G F (1985. ) Effect of tuftsin on in vivo development of 3-methylcholanthrene-induced primary fibrosarcoma and Lewis lung carcinoma in mice. Journal of the National Cancer Institute, , 74 (5 ) ,1079-83

Schantz, S P; Romsdahl, M M; Babcock, G F; Nishioka, K; Goepfert, H (1985. ) The effect of surgery on natural killer cell activity in head and neck cancer patients: in vitro reversal of a postoperatively suppressed immunosurveillance system. The Laryngoscope, , 95 (5 ) ,588-94

Pollock, R E; Babcock, G F; Romsdahl, M M; Nishioka, K (1984. ) Surgical stress-mediated suppression of murine natural killer cell cytotoxicity. Cancer research, , 44 (9 ) ,3888-91

Nishioka, K; Amoscato, A A; Babcock, G F; Banks, R A; Phillips, J H (1984. ) Tuftsin: an immunomodulating peptide hormone and its clinical potential as a natural biological response modifier. Cancer investigation, , 2 (1 ) ,39-49

Lanier, L L; Phillips, J H; Warner, N L; Babcock, G F (1984. ) A human natural killer cell-associated antigen defined by monoclonal antibody anti-Leu (NKP-15): functional and two-color flow cytometry analysis. Journal of leukocyte biology, , 35 (1 ) ,11-7

Lanier, L L; Le, A M; Phillips, J H; Warner, N L; Babcock, G F (1983. ) Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. Journal of immunology (Baltimore, Md. : 1950), , 131 (4 ) ,1789-96

Phillips, J H; Nishioka, K; Babcock, G F (1983. ) Tuftsin-induced enhancement of murine and human natural cell-mediated cytotoxicity. Annals of the New York Academy of Sciences, , 419 ,192-204

Lanier, L L; Engleman, E G; Gatenby, P; Babcock, G F; Warner, N L; Herzenberg, L A (1983. ) Correlation of functional properties of human lymphoid cell subsets and surface marker phenotypes using multiparameter analysis and flow cytometry. Immunological reviews, , 74 ,143-60

Babcock, G F; Phillips, J H (1983. ) Human NK cells: light and electron microscopic characteristics. Survey of immunologic research, , 2 (1 ) ,88-101

Nishioka, K; Babcock, G F; Phillips, J H; Noyes, R D (1981. ) Antitumor effect of tuftsin. Molecular and cellular biochemistry, , 41 ,13-8

Lanier, L L; Babcock, G F; Raybourne, R B; Arnold, L W; Warner, N L; Haughton, G (1980. ) Mechanism of B cell lymphoma immunotherapy with passive xenogeneic anti-idiotype serum. Journal of immunology (Baltimore, Md. : 1950), , 125 (4 ) ,1730-6

Lanier, L L; Babcock, G F; Lynes, M A; Haughton, G (1979. ) Antigen-induced murine B-cell lymphomas. III. Passive anti-idiotype serum therapy and its combined effect with chemotherapy. Journal of the National Cancer Institute, , 63 (6 ) ,1417-22

Banks, R A; Babcock, G F; Whitmore, A C; Haughton, G (1979. ) Effect of immunologic intervention on in vivo murine Rous sarcoma virus tumorigenesis. Journal of the National Cancer Institute, , 63 (6 ) ,1423-31

Lynes, M A; Lanier, L L; Babcock, G F; Wettstein, P J; Haughton, G (1978. ) Antigen-induced murine B cell lymphomas. I. Induction and characterization of CH1 and CH2. Journal of immunology (Baltimore, Md. : 1950), , 121 (6 ) ,2352-7

Haughton, G; Lanier, L L; Babcock, G F (1978. ) The murine kappa light chain shift. Nature, , 275 (5676 ) ,154-7

Whitmore, A C; Babcock, G F; Haughton, G (1978. ) Genetic control of susceptibility of mice to Rous sarcoma virus tumorigenesis. II. Segregation analysis of strain A.SW-associated resistance to primary tumor induction. Journal of immunology (Baltimore, Md. : 1950), , 121 (1 ) ,213-20

Babcock, G F; Lanier, L L; Lynes, M A; Haughton, G (1978. ) A simple method for the preparation of antisera specific for murine immunoglobulin heavy chains. Journal of immunological methods, , 23 (1-2 ) ,1-6

McCarthy, R E; Arnold, L W; Babcock, G F (1977. ) Dextran sulphate: an adjuvant for cell-mediated immune responses. Immunology, , 32 (6 ) ,963-74

Lanier L.;Babcock G.;Lynes M.;Haughton G. (01-01-1979. ) Curative passive immunotherapy of a murine B cell lymphoma with anti-idiotype serum (A-Id) .Proceedings of the American Association for Cancer Research, , Vol. 20 ,

Lanier L.;Babcock G.;Lynes M.;Haughton G. (01-01-1979. ) Anti-idiotype antiserum (A-Id) therapy and its synergistic effect with chemotherapy in the treatment .Federation Proceedings, , 38 (3 II ) ,

Romsdahl M.;Babcock G.;Phillips J.;Nishioka K. (01-01-1981. ) The immunopotentiating effect of tuftsin on human natural cell-mediated cytotoxicity .Proceedings of the American Association for Cancer Research, , Vol. 22 ,1086

Lewis D.;Babcock G.;Templeton J. (01-01-1984. ) A rapid and sensitive flow cytometric method for measuring cell and antibody mediated cytotoxicity .Federation Proceedings, , 43 (6 ) ,

Weiner D.B.;Watson S.R.;Babcock G.;Keller S.J. (01-01-1986. ) Expression of human T antigens in interspecies hybridomas.Cellular Immunology, , 100 (1 ) ,197-209

Lai C.;Babcock G.;Alexander J. (01-01-1986. ) Indefinite survival of rat skin allografts induced by topical cyclosporin A .Surgical Forum, , 37 ,603-604

Perez R.;Heyd T.;Munda R.;Babcock G.;Alexander J. (01-01-1988. ) Induction of long-term rat cardiac allograft survival in rats with multiple donor specific transfusi .Current Surgery, , 45 (1 ) ,9-12

Banks R.;Babcock G.;Nishioka K. (01-01-1988. ) Effect of oral administered or liposome-encapsulated tuftsin on survival of C57BL/6 mic inoculated w .Journal of Experimental and Clinical Cancer Research, , 7 (1 ) ,21-26

Wolos J.;Frondorf K.;Babcock G.;Stripp S.;Bowlin T. (01-01-1993. ) Immunomodulation by an inhibitor of s-adenosyl-l-homocysteine hydrolase: Inhibition of in vitro and .Cellular Immunology, , 149 (2 ) ,402-408

ABDEL?MALEK Z.;SWOPE V.;SMALARA D.;BABCOCK G.;DAWES S.;NORDLUND J. (01-01-1994. ) Analysis of the UV?Induced Melanogenesis and Growth Arrest of Human Melanocytes.Pigment Cell Research, , 7 (5 ) ,326-332

Nordlund J.;Csato M.;Babcock G.;Takei F. (01-01-1995. ) Low ICAM?1 expression in the epidermis of depigmenting C57BL/6J?mivit/mi.Experimental Dermatology, , 4 (1 ) ,20-29

Barker D.;Smalara D.;Im S.;Abdel-Malek Z.;Dixon K.;Mitchell D.;Babcock G.;Medrano E. (09-15-1995. ) Comparison of the Responses of Human Melanocytes with Different Melanin Contents to Ultraviolet B Ir .Cancer Research, , 55 (18 ) ,4041-4046

Tada A.;Suzuki I.;Im S.;Davis M.;Cornelius J.;Babcock G.;Nordlund J.;Abdel-Malek Z. (01-01-1998. ) Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and part .Cell Growth and Differentiation, , 9 (7 ) ,575-584

Alexander J.;Levy A.;Custer D.;Valente J.;Babcock G.;Ogle C.;Schroeder T. (01-01-1998. ) Arginine, fish oil, and donor-specific transfusions independently improve cardiac allograft survival.Journal of Parenteral and Enteral Nutrition, , 22 (3 ) ,152-155

Im S.;Moro O.;Peng F.;Medrano E.;Cornelius J.;Babcock G.;Nordlund J.;Abdel-Malek Z. (01-01-1998. ) Activation of the cyclic AMP pathway by ?-melanotropin mediates the response of human melanocytes to .Cancer Research, , 58 (1 ) ,47-54

Alexander J.W.;Valente J.F.;Greenberg N.A.;Custer D.A.;Ogle C.K.;Gibson S.;Babcock G. (02-01-1999. ) Dietary amino acids as new and novel agents to enhance allograft survival.Nutrition, , 15 (2 ) ,130-134

Sarangarajan R.;Zhao Y.;Babcock G.;Cornelius J.;Lynn Lamoreux M.;Boissy R.E. (10-21-2000. ) Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation.Pigment Cell Research, , 13 (5 ) ,337-344

Le Poole I.C.;Boissy R.E.;Sarancarajan R.;Chen J.;Forristal J.J.;Sheth P.;Westerhof W.;Babcock G.;Das P.K.;Saelinger C.B. (05-01-2000. ) PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum .In Vitro Cellular and Developmental Biology - Animal, , 36 (5 ) ,309-319

O'Brien T.;Babcock G.;Cornelius J.;Dingeldein M.;Talaska G.;Warshawsky D.;Mitchell K. (05-01-2000. ) A comparison of apoptosis and necrosis induced by hepatotoxins in HepG2 cells.Toxicology and Applied Pharmacology, , 164 (3 ) ,280-290

Healy D.;Silverman P.;Neely A.;Holder I.;Babcock G. (01-01-2002. ) Effect of antibiotics on polymorphonuclear neutrophil apoptosis.Pharmacotherapy, , 22 (5 ) ,578-585

Heinen C.;Goss K.;Cornelius J.;Babcock G.;Knudsen E.;Kowalik T.;Groden J. (01-01-2002. ) The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB.Gastroenterology, , 123 (3 ) ,751-763

Healy D.;Enzweiler K.;Neely A.;Holder I.;Babcock G. (12-01-2004. ) Differential effects of amphotericin B and fluconazole on neutrophil CD11b expression.Journal of Infectious Disease Pharmacotherapy, , 6 (4 ) ,59-74

Lanier L.;Lynes M.;Babcock G. (01-01-1978. ) Immunodiagnosis and immunotherapy of a murine B cell lymphoma with a xenogeneic anti-idiotype antise .Federation Proceedings, , 37 (6 ) ,

Kadekaro A.;Kavanagh R.;Kanto H.;Terzieva S.;Hauser J.;Kobayashi N.;Schwemberger S.;Cornelius J.;Babcock G.;Shertzer H.;Scott G.;Abdel-Malek Z. (05-15-2005. ) ?-melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melan.Cancer Research, , 65 (10 ) ,4292-4299

Greatens A.;Hakozaki T.;Koshoffer A.;Epstein H.;Schwemberger S.;Babcock G.;Bissett D.;Takiwaki H.;Arase S.;Wickett R.R.;Boissy R.E. (07-01-2005. ) Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversibl.Experimental Dermatology, , 14 (7 ) ,498-508

Knauf J.;Ouyang B.;Knudsen E.;Fukasawa K.;Babcock G.;Fagin J. (02-17-2006. ) Oncogenic RAS induces accelerated transition through G2/M and promotes defect.Journal of Biological Chemistry, , 281 (7 ) ,3800-3809

Hauser J.;Kadekaro A.;Kavanagh R.;Wakamatsu K.;Terzieva S.;Schwemberger S.;Babcock G.;Rao M.;Ito S.;Abdel-Malek Z. (08-01-2006. ) Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human mela.Pigment Cell Research, , 19 (4 ) ,303-314

Swope V.;Supp A.;Schwemberger S.;Babcock G.;Boyce S. (10-01-2006. ) Increased expression of integrins and decreased apoptosis correlate with increased melanocyte retent.Pigment Cell Research, , 19 (5 ) ,424-433

Babcock G.;Rodeberg D. (12-01-1996. ) Effects of heat shock on human neutrophil degranulation .FASEB Journal, , 10 (6 ) ,

Babcock G.;Meyer J. (03-20-1998. ) The effects of stress on neutrophil function receptor expression, and apoptosis .FASEB Journal, , 12 (5 ) ,

Abdel-Malek Z.A.;Kadekaro A.L.;Kavanagh R.J.;Todorovic A.;Koikov L.N.;McNulty J.C.;Jackson P.J.;Millhauser G.L.;Schwemberger S.;Babcock G.;Haskell-Luevano C.;Knittel J.J. (07-01-2006. ) Melanoma prevention strategy based on using tetrapeptide ?-MSH analogs that protect human melanocyte.FASEB Journal, , 20 (9 ) ,

Dugan A.;Schwemberger S.;Noel G.;Babcock G.;Ogle C.;Horseman N. (02-01-2007. ) Psychogenic stress prior to burn injury has differential effects on bone marrow and cytokine respons .Experimental Biology and Medicine, , 232 (2 ) ,253-261

Abdala-Valencia H.;Earwood J.;Bansal S.;Jansen M.;Babcock G.;Garvy B.;Wills-Karp M.;Cook-Mills J. (05-01-2007. ) Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in exp.American Journal of Physiology - Lung Cellular and Molecular Physiology, , 292 (5 ) ,

Weng D.;Zhang Y.;Hayashi Y.;Kuan C.;Liu C.;Babcock G.;Weng W.;Schwemberger S.;Kao W. (03-20-2008. ) Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice .Molecular Vision, , 14 ,562-571

Osterburg A.;Gardner J.;Hyon S.;Neely A.;Babcock G. (01-01-2009. ) Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea po.Clinical Microbiology and Infection, , 15 (4 ) ,341-346

Hayashi Y.;Call M.;Chikama T.;Liu H.;Carlson E.;Sun Y.;Pearlman E.;Funderburgh J.;Babcock G.;Liu C.;Ohashi Y.;Kao W. (09-01-2010. ) Lumican is required for neutrophil extravasation following corneal injury and wound healing.Journal of Cell Science, , 123 (17 ) ,2987-2995

Hayashi Y.;Call M.;Liu C.;Hayashi M.;Babcock G.;Ohashi Y.;Kao W. (09-01-2010. ) Monoallelic expression Of Krt12 gene during corneal-type epithelium differentiation Of limbal stem c.Investigative Ophthalmology and Visual Science, , 51 (9 ) ,4562-4568

Kadekaro A.L.;Leachman S.;Kavanagh R.J.;Swope V.;Cassidy P.;Supp D.;Sartor M.;Schwemberger S.;Babcock G.;Wakamatsu K.;Ito S.;Koshoffer A.;Boissy R.E.;Manga P.;Sturm R.A.;Abdel-Malek Z.A. (01-01-2010. ) Melanocortin 1 receptor genotype: An important determinant of the damage response of melanocytes to .FASEB Journal, , 24 (10 ) ,3850-3860

Tichy E.;Liang L.;Deng L.;Tischfield J.;Schwemberger S.;Babcock G.;Stambrook P. (04-03-2011. ) Mismatch and base excision repair proficiency in murine embryonic stem cells.DNA Repair, , 10 (4 ) ,445-451

Ebanks J.;Koshoffer A.;Wickett R.;Schwemberger S.;Babcock G.;Hakozaki T.;Boissy R. (01-01-2011. ) Epidermal keratinocytes from light vs. Dark skin exhibit differential degradation of melanosomes.Journal of Investigative Dermatology, , 131 (6 ) ,1226-1233

Swope V.B.;Jameson J.A.;McFarland K.L.;Supp D.M.;Miller W.E.;McGraw D.W.;Patel M.A.;Nix M.A.;Millhauser G.L.;Babcock G.F.;Abdel-Malek Z.A. (01-01-2012. ) Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti s.Journal of Investigative Dermatology, , 132 (9 ) ,2255-2262

Osterburg A.;Mumy K.;Babcock G. (08-29-2013. ) Antibacterial -Acinetobacter baumannii - Activity of Epigallocatechin-3-Gallate (EGCG).Tea in Health and Disease Prevention, , 1195-1206

Swope V.;Alexander C.;Starner R.;Schwemberger S.;Babcock G.;Abdel-Malek Z. (01-01-2014. ) Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultra.Pigment Cell and Melanoma Research, , 27 (4 ) ,601-610


Immunologist,Microbiologist,Cell Biologist,Transplantation Biologist,Immunity,Resistance to Cancer,Immunology,Antibodies,Antigens,Immunogenetics,Immunoregulation,Immunosuppression,Burns,Infectious Diseases,Nutrition and Immunity,Transfusion,Transfusion Problems,Flow Cytometry,Lymphatic,Reticuloendothelial

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Division of Burn Surgery,

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Academic - Shriners Hospitals for Children - Cincinnati
Room 446
Cincinnati  Ohio, 45229
Phone: 513-872-6231