William Ball

William James Ball

Professor, Pharmacology & Cell Biophysics

Professional Summary

A long-term goal of my research program has been to gain an understanding of the structure and functioning of the cation transporter, Na+,K+-ATPase. Of particular interest is the elucidation of how cardiac glycosides (digitalis) bind and inhibit this enzyme’s function by altering its ability to undergo its normal conformational changes. We are also using anti-digitalis monoclonal antibodies, whose structures are known, as model drug receptors in order to better understand drug-receptor binding. These antibodies have also been used as binding templates to identify peptides that may mimic the properties of digitalis. Further, in collaborative efforts with Biotechnology companies we are developing novel, human sequence monoclonal antibodies directed against digitalis (digoxin) and cocaine for therapeutic use in patients. Our experimental approaches to these studies emphasize the use of poly and monoclonal antibodies, combinatorial peptide libraries, immunochemical, kinetic and fluorescence spectroscopy techniques as research tools. Currently, we are determining the effects of our anti-cocaine mAb on the in vivo properties of cocaine and utilizing computer-aided structural-modeling techniques to further aid our studies of drug-receptor/antibody interactions and the determination of enzyme and antibody structures.

Education

Doctoral Degree, University of California at Los Angeles 1973 (Biochemistry )

Master's Degree., California State University at San Diego 1968 (Chemistry)

Bachelor's Degree, San Diego State College 1966 (Chemistry)

Positions and Work Experience

1972 -1975 Postdoctoral Fellow: Division Cellular Metabolism, Sloan Kettering Institute for Cancer Research, New York, New York., Research Project: The study of ornithine decarboxylase in normal and malignant cells. Research Advisor: Dr. M. Earl Balis ,

1976 -1977 Instructor, Department of Pharmacology, Baylor College of Medicine, Houston Texas, Research Project: The study of the control of template specificity of mammalian DNA dependent RNA polymerase II.,

1977 -1981 Instructor, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio,

1981 -1984 Assistant Professor, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio,

1984 -2002 Associate Professor, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio,

2002 - Professor, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, Ohio,

Research and Practice Interests

Drug Abuse Treatment, Anti-cocaine Monoclonal Antibodies, Immunotherapeutics, Drug/Antibody Binding Interactions, Antibody Structure

Research Support

Grant: #0051443B-02-A0-S0-E0 Investigators:Ball, William 07-01-2000 -06-30-2002 American Heart Association - Southwest Chapter Determinants of Human Antibody Affinities for Digoxin Role:PI $90,000.00 Closed Level:Private Non-Profit

Grant: #SW-97-03-S-02-A0-S0-E0 Investigators:Ball, William 10-01-1997 -09-30-1999 American Heart Association - Southwest Chapter Isolation and Characterization of Peptidic Mimics of Digitalis Role:PI $60,000.00 Closed Level:Private Non-Profit

Grant: #DP1 DA031386 Investigators:Ball, William; Norman, Andrew; Tsibulsky, Vladimir 09-30-2010 -07-31-2015 National Institute on Drug Abuse A Human Antibody as an Immunotherapy for Cocaine Abuse (DP1) Role:Collaborator $3,038,892.00 Active Level:Federal

Publications

Published Abstracts

Ball, W.J., Jr., Tse Eng, D., Bilezikian, J.P., Wallick, E.T., Schwartz, A. and Butler, V.P., Jr. (1979. )Studies of a Quinidine Digoxin Interaction .[Abstract]Fed. Proc., 38 (3 ),1042

Ball, W.J., Jr. and Schwartz, A. (1980. )Studies of the Antigenic Properties of Na+,K+ ATPase Dependent ATPase .[Abstract]Fed. Proc., 39 ,1676

Caswell, A., Ball, W.J., Meissner, G., Brandt, W., Branschwig, J., Vaghy, P. and Ferguson, D. (1992. )Immunofluorescence Localization of Triadin, DHP Receptors and Ryanodine Receptors in Skeletal and Heart Muscle. FASEB J., 6 (Abst. 921 ),A161

Carl, S.L., Felix, K., Caswell, A.H., Brandt, N.R., Ball, W.J. Jr., Vaghy, P.L., Meissner, G. and Ferguson, D.G. (1996. )Immunolocalization of DHP Receptors, Ryanodine receptors and Triadin, in Adult Rabbit Atrium and Ventricle .[Abstract]Biophy. J., 62 (2 ),

Therien, A.G., Ball, W.J. and Blostein, R. (1995. )Tissue-specific Versus Isoform Specific Differences in Cation Activation Kinetics of the Na+,K+-ATPase. Biophys. J., 68 ,A307

Balshaw, D.M. and Ball, W.J., Jr. (1996. )Conformational Changes as Determinants of the Sensitivity of the Sodium/Potassium ATPase to the Cardiac Glycosides. Biophys. J., 70 (2 ),A326

Fishwild, D., O’Donnell, S., Hudson, D., Deshpande, U., Qin, S., Mackay, C. and Ball, W. (1998. )Human IgGk Antigen-specific High Affinity Monoclonal Antibodies from Transgenic Mice .[Abstract]The FASEB Journal, 12 (4 ),p. A309

Peer Reviewed Publications

Norman, Andrew B; Ball, William J (2012. )Predicting the clinical efficacy and potential adverse effects of a humanized anticocaine monoclonal antibody.Immunotherapy, ,4 (3 ),335-43

Lape, Michael; Paula, Stefan; Ball, William J (2010. )A molecular model for cocaine binding by the immunotherapeutic human/mouse chimeric monoclonal antibody 2E2.European journal of medicinal chemistry, ,45 (6 ),2291-8

Norman, Andrew B; Norman, Mantana K; Buesing, William R; Tabet, Michael R; Tsibulsky, Vladimir L; Ball, William J (2009. )The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats.The Journal of pharmacology and experimental therapeutics, ,328 (3 ),873-81

Seligson, D., Rajasekaran, S. A., Yu, H., Liu, X., Eeva, M., Tze, S., Ball, W. J. Jr., Horvath, S., deKernin, J. and Rajasekaran, A. K. (2008. )Na, K-ATPase α1-Subunit Predicts Survival in Renal Clear Cell Carcinoma. J. Urology, ,179 ,338-345

Norman, A.B., Tabet, M.R., Norman, M.K., Buesing, W.R., Pesce, A.J. and Ball, W.J. (2007. )A Chimeric human/murine Anti-cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Mice. J. Pharmacology Experimental Therapeutics, ,320 ,145-153

Norman, Andrew B; Tabet, Michael R; Norman, Mantana K; Buesing, William R; Pesce, Amadeo J; Ball, William J (2007. )A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice.The Journal of pharmacology and experimental therapeutics, ,320 (1 ),145-53

Paula, Stefan; Monson, Nancy; Ball, William James (2005. )Molecular modeling of cardiac glycoside binding by the human sequence monoclonal antibody 1B3.Proteins, ,60 (3 ),382-91

Keenan, Susan M; DeLisle, Robert K; Welsh, William J; Paula, Stefan; Ball, William J (2005. )Elucidation of the Na+, K+-ATPase digitalis binding site.Journal of molecular graphics & modelling, ,23 (6 ),465-75

Paula, Stefan; Tabet, Michael R; Ball, William James (2005. )Interactions between cardiac glycosides and sodium/potassium-ATPase: three-dimensional structure-activity relationship models for ligand binding to the E2-Pi form of the enzyme versus activity inhibition.Biochemistry, ,44 (2 ),498-510

Paula, S., Tabet, M. R. and Ball, W. J. Jr. (2005. )Interactions between Cardiac Glycosides and Na/K-ATPase: 3D Structure-Activity Relationship Models for Ligand Binding to the E2-Pi form of the Enzyme versus Activity Inhibition. Biochem., ,44 ,498-510

Paula, S., Monson, N. and Ball, W. J. Jr. (2005. )Molecular Modeling of Cardiac Glycoside Binding to the Human Sequence Monoclonal Antibody 1B3. Proteins: Structure, Function and Bioinform., ,60 ,382-391

Keenan, S.M., DeLisle, R.K., Paula, S., Welsh, W.J. and Ball, W.J. (2005. )Elucidation of the Na+, K+-ATPase Digitalis Binding Site .J. Mol. Graphics & Modeling., ,23 ,465-475

Paula, S., Tabet, M.R., Farr, C.D., Norman, A.B. and Ball, W.J. (2004. )3D-QSAR Modeling of Cocaine Binding by a Novel Human Antibody. J. Medicinal Chemistry, ,47 ,133-142

Paula, S. and Ball, W. J. Jr. (2004. )Molecular Determinants of Thapsigargin Binding by SERCA Ca2+-ATPAse: A Computational Docking Study. Proteins: Structure, Function and Bioinform., ,56 ,595-606

Paula, Stefan; Ball, William James (2004. )Molecular determinants of thapsigargin binding by SERCA Ca2+-ATPase: a computational docking study.Proteins, ,56 (3 ),595-606

Paula, Stefan; Tabet, Michael R; Farr, Carol D; Norman, Andrew B; Ball, W James (2004. )Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody.Journal of medicinal chemistry, ,47 (1 ),133-42

Ball, W James; Farr, Carol D; Paula, Stefan; Keenan, Susan M; Delisle, Robert K; Welsh, William J (2003. )Three-dimensional structure-activity relationship modeling of digoxin inhibition and docking to Na+,K+-ATPase. Annals of the New York Academy of Sciences, ,986 ,296-7

Paula, Stefan; Tabet, Michael R; Keenan, Susan M; Welsh, William J; Ball, W James (2003. )Three-dimensional structure-activity relationship modeling of cocaine binding to two monoclonal antibodies by comparative molecular field analysis. Journal of molecular biology, ,325 (3 ),515-30

Paula, S., Tabet, M., Keenan, S., Welsh, W. and Ball, W.J., Jr. (2003. )3D Structure-Activity Relationship Modeling of Cocaine Binding to Two Monoclonal Antibodies by Comparative Molecular Field Analysis. J. Mol. Biol., ,325 ,515-530

Espineda, C., Seligson, D., Ball, W.J., Jr., Rao, J.Y., Palotie, A., Shi, T., Huang, Y., Horvath, S. and Rajasekaran, A.K. (2003. )Analysis of the Clinical Significance of Na,K-ATPase - and -subunit Expression Profiles of the Bladder Cancer using Tissue Microassays .Cancer, ,97 ,1859-1868

Farr, C.D., Burd, C., Tabet, M.R., Wang, X., Welsh, W.J. and Ball, W. J., Jr. (2002. )Three-Dimensional Quantitative Structure-Activity Relationship of the Inhibition of the Na+,K+-ATPase by Cardiotonic Steroids Using Comparative Molecular Field Analysis. Biochemistry, ,41 ,1137-1148

Farr, C.D., Tabet, M.R., Fishwild, D.M., Wang, X., Nair, A.C., Welsh, W.J. and Ball, W. J., Jr. (2002. )Three-Dimensional Quantitative Structure Activity Relationship Analysis of Ligand Binding to Human Sequence Anti-Digoxin Monoclonal Antibodies Using Comparative Molecular Field Analysis .J. Medicinal Chemistry, ,45 ,3257-3270

Farr, Carol D; Tabet, Michael R; Ball, William J; Fishwild, Dianne M; Wang, Xia; Nair, Anil C; Welsh, William J (2002. )Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis. Journal of medicinal chemistry, ,45 (15 ),3257-70

Farr, Carol D; Burd, Craig; Tabet, Michael R; Wang, Xia; Welsh, William J; Ball, William J (2002. )Three-dimensional quantitative structure-activity relationship study of the inhibition of Na(+),K(+)-ATPase by cardiotonic steroids using comparative molecular field analysis. Biochemistry, ,41 (4 ),1137-48

Rajasekaran, S A; Palmer, L G; Quan, K; Harper, J F; Ball, W J; Bander, N H; Peralta Soler, A; Rajasekaran, A K (2001. )Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility. Molecular biology of the cell, ,12 (2 ),279-95

Rajasekaran, S.A., Palmer, L.G., Bander, N., Ball, W. J., Jr., Quan, K., Harper, J., Sober, A. and Rajasekaran, A.K. (2001. )Na, K-ATPase -Subunit is Required for Epithelial Polarization, suppression of Invasion and Cell Mobility. Mol. Biology Cell, ,12 (2 ),279-295

Ball, W. J., Jr., Wang, Z.M., Malik, B., Kasturi, R., Dey, P., Short, M. and Margolies, M. (2000. )Selection of Peptidic Mimics of Digoxin from Combinatorial Peptide Libraries by Anti-digoxin Antibodies .J. Mol. Biol., ,301 ,101-115

Ball, W J; Wang, Z; Malik, B; Kasturi, R; Dey, P; Short, M K; Margolies, M N (2000. )Selection of peptidic mimics of digoxin from phage-displayed peptide libraries by anti-digoxin antibodies.Journal of molecular biology, ,301 (1 ),101-15

Ball, W J; Kasturi, R; Dey, P; Tabet, M; O'Donnell, S; Hudson, D; Fishwild, D (1999. )Isolation and characterization of human monoclonal antibodies to digoxin. Journal of immunology (Baltimore, Md. : 1950), ,163 (4 ),2291-8

Rajasekaran, S A; Ball, W J; Bander, N H; Liu, H; Pardee, J D; Rajasekaran, A K (1999. )Reduced expression of beta-subunit of Na,K-ATPase in human clear-cell renal cell carcinoma. The Journal of urology, ,162 (2 ),574-80

Rajasekaran, S., Ball, W.J., Bander, N.H., Liu, N.H., Pardee, J.D. and Rajasekaran, A.K. (1999. )Reduced Expression of -Subunit of Na+,K+-ATPase in Human Clear-Cell Renal-Cell Carcinoma .J. Urology, ,162 ,574-580

Ball, W. J., Jr., Kasturi, R., Dey, P., O’Donnell, S., Hudson, D. and Fishwild, D. (1999. )Isolation and Characterization of Human Monoclonal Antibodies to Digoxin .J. Immunology, ,163 ,2291-2298

Kasturi, R; Yuan, J; McLean, L R; Margolies, M N; Ball, W J (1998. )Identification of a model cardiac glycoside receptor: comparisons with Na+,K+-ATPase.Biochemistry, ,37 (19 ),6658-66

Kasturi, R., Yuan, J., McLean, L., Margolies, M. and Ball, W. J., Jr. (1998. )Identification of a Model Cardiac Glycoside Receptor. Biochemistry, ,37 ,6658-6666

Kasturi, R; McLean, L R; Margolies, M N; Ball, W J (1997. )High affinity anti-digoxin antibodies as model receptors for cardiac glycosides. Comparisons with Na+,K(+)-ATPase. Annals of the New York Academy of Sciences, ,834 ,634-6

Therien, A G; Nestor, N B; Ball, W J; Blostein, R (1996. )Tissue-specific versus isoform-specific differences in cation activation kinetics of the Na,K-ATPase. The Journal of biological chemistry, ,271 (12 ),7104-12

Amler, E; Abbott, A; Malak, H; Lakowicz, J; Ball, W J (1996. )The carbohydrate moieties of the beta-subunit of Na+, K(+)-ATPase: their lateral motions and proximity to the cardiac glycoside site.Biophysical journal, ,70 (1 ),182-93

Amler, E., Abbott, A., Malak, H., Lakowicz, J. and Ball, W. J., Jr. (1996. )The Carbohydrate Moieties of the ß subunit of Na+,K+ ATPase: Their Lateral Motions and Proximity to the Cardiac Glycoside Site. Biophys. J., ,70 ,182-193

Therien, A.G., Nestor, N.B., Ball, W. J., Jr. and Blostein, R. (1996. )Tissue-Specific Versus Isoform-Specific Differences in Cation Activation Kinetics of the Na+,K+-ATPase. J. Biol. Chem., ,271 ,7104-7112

Carl, S.L., Felix, K., Caswell, A.H., Brandt, N.R., Ball, W.J., Vaghy, P., Meissner, G., and Ferguson, D.G. (1995. )Immunolocalization of Sarcolemmal Dihydropyridine Receptor and Sarcoplasmic Reticular Triadin and Ryanodine Receptor in Rabbit Ventricle and Atrium. J. Cell Biology, ,129 ,673-682

Carl, S L; Felix, K; Caswell, A H; Brandt, N R; Ball, W J; Vaghy, P L; Meissner, G; Ferguson, D G (1995. )Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium. The Journal of cell biology, ,129 (3 ),673-82

Sun, Y; Ball, W J (1994. )Identification of antigenic sites on the Na+/K(+)-ATPase beta-subunit: their sequences and the effects of thiol reduction upon their structure. Biochimica et biophysica acta, ,1207 (2 ),236-48

Sun, Y. and Ball, W. J., Jr. (1994. )Identification of Antigenic Sites on the Na+,K+-ATPase * Subunit: Their sequences and the affects of thiol reduction upon their structure. Biochim. Biophys. Acta, ,1207 ,236-248

Abbott, A. and Ball, W. J., Jr. (1993. )The Epitope on for the Inhibitory Antibody M7 PB E9 Contains Ser 646 and Asp 652 of the Sheep Na+,K+ ATPase, * Subunit. Biochemistry, ,32 ,3511-3518

Malik, B., Jamieson, G., and Ball, W.J. (1993. )Identification of the Amino Acids Comprising a Surface Exposed Epitope Within the Nucleotide-Binding Domain of the Na+,K+-ATPase Using a Random Peptide Library. Protein Sciences, ,2 ,2103-2111

Malik, B; Jamieson, G A; Ball, W J (1993. )Identification of the amino acids comprising a surface-exposed epitope within the nucleotide-binding domain of the Na+,K(+)-ATPase using a random peptide library.Protein science : a publication of the Protein Society, ,2 (12 ),2103-11

Abbott, A; Ball, W J (1993. )The epitope for the inhibitory antibody M7-PB-E9 contains Ser-646 and Asp-652 of the sheep Na+,K(+)-ATPase alpha-subunit. Biochemistry, ,32 (13 ),3511-8

Ball, W J; Abbott, A; Sun, Y; Malik, B (1992. )Monoclonal antibodies and the identification of functional regions of the Na+,K(+)-ATPase. Annals of the New York Academy of Sciences, ,671 ,436-9

Abbott, A; Ball, W J (1992. )The inhibitory monoclonal antibody M7-PB-E9 stabilizes E2 conformational states of Na+,K(+)-ATPase. Biochemistry, ,31 (45 ),11236-43

Incerpi, S; Jefferson, J R; Wood, W G; Ball, W J; Schroeder, F (1992. )Na pump and plasma membrane structure in L-cell fibroblasts expressing rat liver fatty acid binding protein. Archives of biochemistry and biophysics, ,298 (1 ),35-42

Sun, Y; Ball, W J (1992. )Determination of Na(+)-K(+)-ATPase alpha- and beta-isoforms and kinetic properties in mammalian liver. The American journal of physiology, ,262 (6 Pt 1 ),C1491-9

Amler, E; Abbott, A; Ball, W J (1992. )Structural dynamics and oligomeric interactions of Na+,K(+)-ATPase as monitored using fluorescence energy transfer.Biophysical journal, ,61 (2 ),553-68

Amler, E., Abbott, A. and Ball, W. J., Jr. (1992. )Structural Dynamics and Oligomeric Interactions of Na+,K+ ATPase as Monitored Using Fluorescence Energy Transfer .Biophys. J., ,61 ,553-568

Sun, Y. and Ball, W. J., Jr. (1992. )Determination of Na+,K+ ATPase * and ß isoforms and Kinetic Properties in Mammalian Liver. Amer. J. Physiol., ,262 ,C1491-C1499

Incerpi, S., Jefferson, J.R., Wood, W.G., Ball, W.J. and Schroeder, F. (1992. )Na+ Pump and Plasma Membrane Structure in L Cell Fibroblasts Expressing Rat Liver Fatty Acid Binding Protein. Archives of Biochem. Biophys., ,298 (1 ),35-42

Abbott, A. and Ball, W. J., Jr. (1992. )The Inhibitory Monoclonal Antibody M7 PB E9 Stabilizes the E2 Conformational States of Na+,K+ ATPase. Biochemistry., ,31 ,11236-11243

Abbott, A., Amler, E. and Ball, W. J., Jr. (1991. )Spectroscopic Characterization of Two FITC Labeling Sites on Na+,K+ ATPase and Their Environments .Biochemistry, ,30 (6 ),1692-1701

Abbott, A J; Amler, E; Ball, W J (1991. )Immunochemical and spectroscopic characterization of two fluorescein 5'-isothiocyanate labeling sites on Na+,K(+)-ATPase. Biochemistry, ,30 (6 ),1692-701

Ting-Beall, H P; Beall, H C; Hastings, D F; Friedman, M L; Ball, W J (1990. )Identification of monoclonal antibody binding domains of Na+,K(+)-ATPase by immunoelectron microscopy. FEBS letters, ,265 (1-2 ),121-5

Ting Beall, H.P., Beall, H.C., Hastings, D.F., Friedman, M.L. and Ball, W. J., Jr. (1990. )Identification of Monoclonal Antibody Binding Domains on Na+,K+ ATPase by Immunoelectron Microscopy. FEBS Letters, ,265 ,121-125

Friedman, M. and Ball, W. J., Jr. (1989. )Determination of Monoclonal Antibody Induced Alterations in Na+,K+ ATPase Conformation Using Fluorescein labeled Enzyme. Biochim. Biophys. Acta, ,995 ,42-53

Friedman, M L; Ball, W J (1989. )Determination of monoclonal antibody-induced alterations in Na+/K+-ATPase conformations using fluorescein-labeled enzyme. Biochimica et biophysica acta, ,995 (1 ),42-53

Ball, W J; Kirley, T L; Lane, L K (1988. )Preparation of antibodies to Na+,K+-ATPase and its subunits. Methods in enzymology, ,156 ,87-101

Schwartz, A; Grupp, G; Wallick, E; Grupp, I L; Ball, W J (1988. )Role of the Na+K+-ATPase in the cardiotonic action of cardiac glycosides. Progress in clinical and biological research, ,268B ,321-38

Ball, W J; Loftice, C D (1987. )Immunochemical studies of (Na+ + K+)-ATPase using site-specific, synthetic peptide directed antibodies. Biochimica et biophysica acta, ,916 (1 ),100-11

Ball, W J; Friedman, M L (1987. )Immunochemical evidence that the FITC-labeling site on Na+,K+-ATPase is not the ATP binding site. Biochemical and biophysical research communications, ,148 (1 ),246-53

Ball, W. J., Jr. and Loftice, C.D. (1987. )Immunochemical Studies of (Na++K+) ATPase Using Site Specific Synthetic Peptide Directed Antibodies .Biochim. Biophys. Acta., ,916 ,100-111

Ball, W. J., Jr. and Friedman, M.L. (1987. )Immunochemical Evidence that the FITC Labeling Site on Na+,K+ ATPase is Not the ATP Binding Site .Biochem. Biophys. Res. Commun., ,148 ,246-253

Ball, W. J., Jr. and Lane, L.K. (1986. )Immunochemical Comparison of Cardiac Glycoside Sensitive (lamb) and Insensitive (rat) Kidney Na+,K+ ATPases .Biochim. Biophys. Acta, ,873 ,79-87

Lane, L.K., Kirley, T.L. and Ball, W. J., Jr. (1986. )Structural Studies on H+,K+ ATPase: Determination of the NH2 Terminal Amino Acid Sequence and Immunological Cross Reactivity with Na+,K+ ATPase .Biochim. Biophys. Res. Comm., ,138 ,185-192

Ball, W. J., Jr. (1986. )Uncoupling of ATP Binding to Na+,K+ ATPase from its Stimulation of Ouabain Binding .Biochemistry, ,25 ,7155-7162

Ball, W J (1986. )Uncoupling of ATP binding to Na+,K+-ATPase from its stimulation of ouabain binding: studies of the inhibition of Na+,K+-ATPase by a monoclonal antibody. Biochemistry, ,25 (22 ),7155-62

Ball, W J; Lane, L K (1986. )Immunochemical comparison of cardiac glycoside-sensitive (lamb) and -insensitive (rat) kidney (Na+ + K+)-ATPase. Biochimica et biophysica acta, ,873 (1 ),79-87

Lane, L K; Kirley, T L; Ball, W J (1986. )Structural studies on H+,K+-ATPase: determination of the NH2-terminal amino acid sequence and immunological cross-reactivity with Na+,K+-ATPase. Biochemical and biophysical research communications, ,138 (1 ),185-92

Ball, W J (1984. )Immunochemical characterization of a functional site of (Na+,K+)-ATPase. Biochemistry, ,23 (10 ),2275-81

Ball, W. J., Jr. (1984. )Immunochemical Characterization of a Functional Site of Na+,K+ ATPase .Biochemistry, ,23 ,2275-2281

Ball, W. J., Jr., Collins, J.H., Lane, L.K. and Schwartz, A (1983. )The Antigenic Properties of the * , ß , , Components of Na+,K+ ATPase, Current Topics in Membranes and Transport (Ed. F. Bronner and A. Kleinzeller) .Academic Press, ,19 ,781-785

Ball, W. J., Jr., Collins, J.H., Lane, L.K. and Schwartz, A. (1983. )Studies of the Antigenic Properties of the Catalytic and Glycoprotein Subunits of Na+,K+ ATPase .Arch. Biochem. Biophys., ,221 ,371-380

Collins, J.H., Zot, A.S., Ball, W. J., Jr., Lane, L.K. and Schwartz, A. (1983. )Structure of Lamb Kidney Na+,K+ ATPase: Tryptic Digest of the * Subunit .Biochim. Biophys. Acta, ,742 ,358-365

Ball, W J; Collins, J H; Lane, L K; Schwartz, A (1983. )Studies of the antigenic properties of the catalytic and glycoprotein subunits of Na+,K+-ATPase. Archives of biochemistry and biophysics, ,221 (2 ),371-80

Collins, J H; Zot, A S; Ball, W J; Lane, L K; Schwartz, A (1983. )Tryptic digest of the alpha subunit of lamb kidney (Na+ + K+)-ATPase. Biochimica et biophysica acta, ,742 (2 ),358-65

Ball, W J; Schwartz, A; Lessard, J L (1982. )Isolation and characterization of monoclonal antibodies to (Na+ + K+)-ATPase. Biochimica et biophysica acta, ,719 (3 ),413-23

Ball, W J; Schwartz, A (1982. )Studies of the antigenic properties of sheep kidney Na+,K+-ATPase. Archives of biochemistry and biophysics, ,217 (1 ),110-9

Ball, W. J., Jr. and Schwartz, A. (1982. )Studies of the Antigenic Properties of Sheep Kidney Na+,K+ ATPase .Arch. Biochem. Biophys., ,217 ,110-119

Ball, W. J., Jr., Schwartz, A. and Lessard, J. (1982. )Isolation and Characterization of monoclonal antibodies to Na+,K+ ATPase .Biochim. Biophys. Acta, ,719 ,413-423

Ball, W. J., Jr., Tse Eng, D., Wallick, E. T., Bilezikjian, J. P., Schwartz, A. and Butler, V. P., Jr. (1981. )Effect of Quinidine on the Digoxin Receptor In Vitro .J. Clin. Invest., ,68 ,1065-1074

Ball, W J; Tse-Eng, D; Wallick, E T; Bilezikian, J P; Schwartz, A; Butler, V P (1981. )Effect of quinidine on the digoxin receptor in vitro. The Journal of clinical investigation, ,68 (4 ),1065-74

Schwartz, A; Adams, R J; Ball, W J; Collins, J H; Gupte, S S; Lane, L K; Reeves, A S; Wallick, E T (1980. )Structure, function and regulation of Na-K-ATPase. The International journal of biochemistry, ,12 (1-2 ),287-93

Schwartz, A., Adams, R. J., Ball, W. J., Jr., Collins, J. H., Gupte, S., Lane, L. K. and Wallick, E. T. (1980. )Structure, Function and Regulation of Kidney Na,K ATPase .Inter. J. Biochem., ,12 ,287-293

Ball, W. J., Jr., Salser, J. S. and Balis, M. E. (1976. )Biochemical Changes in Preneoplastic Rodent Intestines .Cancer Res., ,36 ,2686-2689

Ball, W. J., Jr. and Balis, M. E. (1976. )Changes in Ornithine Decarboxylase Activity in Rat Intestines During Aging .Cancer Res, ,36 ,3312-3316

Salser, J. S., Ball, W. J., Jr. and Balis, M. E. (1976. )Biochemical Changes in Premalignant Intestine .Cancer Res., ,36 ,3494-3498

Salser, J S; Ball, W J; Balis, M E (1976. )Biochemical changes in premalignant intestines. Cancer research, ,36 (9 PT 2 ),3495-8

Ball, W J; Balis, M E (1976. )Changes in ornithine decarboxylase activity in rat intestines during aging. Cancer research, ,36 (9 pt.1 ),3312-6

Ball, W J; Salser, J S; Balis, M E (1976. )Biochemical changes in preneoplastic rodent intestines. Cancer research, ,36 (7 PT 2 ),2686-9

Ball, W J; Csurny, R; Moller, M; Balis, M E (1975. )Lack of effect of portacaval shunt on ornithine decarboxylase activity in regenerating rat liver. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), ,150 (2 ),380-4

Ball, W J; Atkinson, D E (1975. )Adenylate energy charge in Saccharomyces cerevisiae during starvation. Journal of bacteriology, ,121 (3 ),975-82

Ball, W. J., Jr. and Atkinson, D. E. (1975. )Adenylate Energy Charge in Saccharomyces cerevisiae During Starvation .J. Bacteriol., ,121 ,975-982

Ball, W. J., Jr., Csurny, R., Moller, M. and Balis, M. E. (1975. )Lack of Effect of Portacaval Shunt on Ornithine Decarboxylase Activity in Regenerating Rat Liver .Proc. Exp. Biol. Med., ,150 ,380-384

Balis, M. E., Ball, W. J., Jr., Salser, J. S. and Yip, L. C (1974. )Effect of Drugs on Cells at Various Stages of Differentiation in Intestinal Epithelium .In: Priorities in Perinatal Pharmacology, Dancis J. and Hwang, J. D. eds., Raven press, ,

Stewart, C. J., Thomas, J. O., Ball, W. J., Jr. and Aguirre, A. J (1968. )Coenzyme A Analogs. III. J. Amer. Chem. Soc., ,90 ,5000-5004

Stewart, C J; Thomas, J O; Ball, W J; Aguirre, A R (1968. )Coenzyme A analogs. 3. The chemical synthesis of desulfopantetheine 4'-phosphate and its enzymatic conversion to desulfo-coenzyme A. Journal of the American Chemical Society, ,90 (18 ),5000-4

Stewart, C. J. and Ball, W. J (1966. )Coenzyme A Analogs. II. Biochemistry, ,5 ,3833-3836

Norman, Andrew B; Gooden, Felicia C T; Tabet, Michael R; Ball, William J (2014. )A Recombinant Humanized Anti-cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats.Drug metabolism and disposition: the biological fate of chemicals, ,

Ball, W.J. Jr., Garbett, N.C , Tabet, M.R., Tabaja, N., Norman, A.B. (2014. )The Re- Engineered Humanized anti-Cocaine Monoclonal Antibody h2E2: Analysis of its Thermo- and pH -Stability and Energetics of Ligand Bindings .In preparation, ,

Felicia C.T. Gooden, Hanna Dasenbrock, Kelli Edwards, Michael R. Tabet, William J. Ball, and Andrew B. Norman (2014. )The effects of humanized anti-cocaine monoclonal antibody h2E2 on distribution and metabolism of cocaine in vivo and in vitro. In Preparation, ,

Hanna N. Wetzel, Felicia C.T. Gooden, Michael R. Tabet, William J. Ball, Andrew B. Norman (2014. )The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice .In Preparation., ,

Wetzel, Hanna N; Tabet, Michael R; Ball, William J; Norman, Andrew B (2014. )The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice.International immunopharmacology, ,23 (2 ),387-90

Invited Publications

Ball, W. J., Jr. and Lane, L.K. (1985. )Rat and Lamb Kidney Na,K ATPase: An Immunochemical Comparison. In The Sodium Pump, 4th International Conference on Na,K ATPase. Eds. I.M. Glynn and J.C. Ellery, The Company of Biologists, Ltd., 135-139

Ball, W. J., Jr. (1984. )Monoclonal Antibody Effects on the Interactions of Functional Sites of the Na+,K+ ATPase .Third European Bioenergetics Conference, ICSU Press, 3B ,393-394

Ball, W. J., Jr., Kirley, T.L. and Lane, L.K. (1988. )The Na+,K+ ATPase: Preparation of Antibodies to Na+,K+ ATPase and Its Subunits .Methods of Enzymology, Biomembrane Series, Part P, (Eds. S. Fleischer & B. Fleischer), 156 ,87-101

Schwartz, A., Grupp, G., Grupp, I., Wallick, E. and Ball, W. (1988. )Role of the Na+,K+ ATPase in the Cardiotonic Action of Cardiac Glycosides .Prog. in Clinical & Biol. Res., The Na+,K+ Pump, Part B: Cellular Aspects (Eds. J. Skou, J. Norby, A. Maunsbach, & M. Esman) Alan R. Liss, Inc., New York, 268B ,

Sun, Y. and Ball, W. J., Jr. (1991. )Immunodetection of the ß Subunit of Na+,K+ ATPase in Mammalian Liver Tissues .The Na+ Pump Recent Development, (Ed. J. Kaplan), Rockefeller Univ. Press, New York, 2 ,275-280

Ball, W. J., Jr., Abbott, A., Sun, Y., and Malik, B. (1992. )Monoclonal Antibodies and the Identification of Functional Regions of the Na+,K+ ATPase .Ion Motive ATPases: Structure, Function and Regulation. Annals of New York Academy of Science., 671 ,436-439

Kasturi, R., McLean, L.R., Margolies, M.N. and Ball, W. J., Jr. (1997. )High Affinity Antidigoxin Antibodies as Model Receptors for Cardiac Glycosides. Annals New York Academy Sciences., 834 ,634-637

Ball, W. J., Jr., Farr, C., Paula, S., Keenan, S., Delisle, R. and Welsh, W. (2002. )3D Structure-Activity Relationship Modeling of Digoxin Inhibition and Docking to Na+,K+-ATPase .Annals New York Acad. Sci., 986 ,286-297

Ball, W.J., Paula, S. Farr, C., Williams, D., Welsh, W.J. and Norman, A.B. (2003. )Immunotoxicotherapy with Human Anti-drug Antibodies. Human Antibodies, 12 ,27-30

Additional Publications

Editorial

W. James Ball, Jr. (2007. )UC at Risk Because of Ambition .The Enquirer, Sunday, July 15,

Presentations

Lecture

(06-16-2007. )Humanized Anti-cocaine Monoclonal Antibody as a Potential Immunotherapy for cocaine abuse. Quebec City, Canada.

(01-20-2006. )The Theory and Practice of Assay Development .Mason, OH.

(10-10-2003. )Immunotoxicotherapy with Human Anti-drug Monoclonal Antibodies .Osaka, Japan.

(09-22-2003. )Development of Antibody Treatments for Cocaine Abuse .Cincinnati, OH.

(04-25-2003. )The Development of a Human Anti-Cocaine mAb for the Clinic .Fort Detrick.

(02-19-2003. )Development of a Human Anti-Cocaine Antibody for Treatment of Cocaine Addiction .Cincinnati, OH.

(06-12-2002. )Generation and characterization of a Human Anti-Cocaine Antibody: Presentation “Late-Breaking News” .Quebec, Canada.

(03-20-2002. )Anti-Cocaine Antibodies: Development and Use .University of Cincinnati College of Medicine.

(12-05-2001. )Immunotoxicotherapy: Perspectives and Development of Human Anti-digoxin Monoclonal Antibodies .Bloomsbury, NJ.

(05-25-2001. )Human Sequence Anti-Cocaine Monoclonal Antibody Development .Bethesda, MD.

(05-11-2001. )Immunotoxicotherapy: Development of anti-digitalis and anti-cocaine antibodies .UCLA.

(04-28-2000. )Immunotoxicotherapy: Studies with Anti-digoxin Antibodies .University of Cincinnati.

(01-2000. )Practical Issues in the Use of Fab Rescue for Digitalis Toxicity .

(11-17-1998. )All About Antibodies: Humanized and Human mAbs .

(02-17-1998. )Monoclonal Antibodies as Models of the Digitalis Receptor .Indianapolis, IN.

(01-2004. )The Na+-Pump -Using Antibodies to Study its Topology and Functional Sites .Alberta, Canada.

(09-1992. )Monoclonal Antibodies and the Identification of Functional Regions of the Na+,K+ ATPase .Toledo, OH.

(1991. )Determining the Topology of the Na+ pump .

(05-1990. )The Sodium Pump: Probing for functional Sites .

(11-1989. )Antibody Induced Alterations in Na+,K+ ATPase Conformation .

(04-1989. )Immunochemical Studies on Na+,K+ ATPase .Baltimore, Maryland.

(02-1989. )Immunological Studies of the Na+,K+ ATPase: Structure and function .Dayton, OH.

(03-1986. )Immunological Studies of the Digitalis Receptor .Boston, Mass..

(1985. )Membrane proteins: Structure and function .Cincinnati, OH.

(1984. )The Use of Monoclonal Antibodies to Study the Function of Na+,K+-ATPase .Michigan.

(1984. )Immunological Studies of the Na+,K+-ATPase .Lexington, KY.

(1984. )Antigenic Properties of the  and  subunits of Na+,K+-ATPase .Columbia, Missouri.

(01-26-1984. )Monoclonal Antibodies: Their Use in Studies of the Na+,K+ ATPase .University of Cincinnati.

(1983. )Isolation and Characterization of Monoclonal Antibodies to the Na+,K+ ATPase .University of Cincinnati College of Medicine.

(02-17-1983. )Studies of the Immunochemical Properties of Na+,K+ ATPase .California.

Paper Presentations

Ball, W.J., Jr. and Schwartz, A. (1981. )Antigenic Properties of Catalytic and Glycoprotein Subunits of Na+,K+ ATPase .New Haven, CT.

Ball, W.J., Jr., Collins, J.H., Lane, L.K. and Schwartz, A. (1981. )Antigenic Properties of the Catalytic, Glycoprotein and Proteolipid components of Na+,K+ ATPase .New Haven, CT.

Collins, J.H., Ball, W.J., Jr., Lane, L.K. and Zot, A.S. (1981. )Sequence Studies on Na+,K+ ATPase .

Ball, W.J., Jr. (1983. )Isolation and Characterization of Monoclonal Antibodies to Na+,K+ ATPase .Washington, DC.

Ball, W.J., Jr. (1983. )Immunochemical Studies of Functional Site Interactions of Na+,K+ ATPase .Washington, DC (Invited to Discussions but did not attend).

Ball, W.J., Jr. and Lane, L.K. (1983. )Immunochemical Comparison of the Cardiac Glycoside sensitive (lamb) and insensitive (rat) kidney Na+,K+ ATPases .Dallas, TX.

Ball, W.J., Jr. (08-1984. )Studies of Monoclonal Antibody Effects on lamb kidney Na+,K+ ATPase function .Bristol, United Kingdom.

Ball, W.J., Jr. (08-1984. )Immunological studies of the Na+,K+ ATPase .United Kingdom.

Ball, W.J., Jr. (09-1984. )Studies of Na+,K+ ATPase Functional Site Interactions .Hanover, Germany.

Ball, W.J., Jr. (1986. )Alteration in Enzyme Flexibility: Mechanism of inhibition of Na+,K+ ATPase, by a monoclonal antibody .Boston, MA.

Ball, W.J., Jr. and Loftice, C.D. (1987. )Locating Antigenic Determinants of the * Subunit of Na+,K+ ATPase .New Orleans, LA.

Friedman, M.L. and Ball, W.J., Jr. (1987. )Stabilization of the Mg2+*E1 Conformation of Na+,K+ ATPase by Monoclonal Antibody Binding .New Orleans, LA.

Ball, W.J., Friedman, M.L., Loftice, C. and Sun, Y. (1987. )Site Specific Antibodies as Probes of Na+,K+ ATPase Structure .Ärhus, Denmark.

Ball, W.J., Friedman, M.L. and Sun, Y. (07-1988. )Determination of Na+,K+ ATPase Functional Sites and Interactions Using Monoclonal Antibodies .Prague, Czechoslovakia.

Sun, Y and Ball, W.J., Jr. (09-1990. )Immunodetection of the ß Subunit of Na+,K+ ATPase in Mammalian Liver tissues. Woodshole, Mass..

Amler, E., Abbott, A., and Ball, W.J., Jr. (07-1990. )Topology of the ATP Binding Site on Na+,K+ ATPase: Forester Energy Transfer Study .Vancouver, Canada.

Abbott, A., Amler, E. and Ball, W.J. Jr. (07-1990. )Demonstration of Two Distinct FITC labeling Sites on the Na+,K+ ATPase using Anti FITC Antibodies .Vancouver, Canada.

Amler, E., Malak, H., Abbott, A., Lakowicz, J. and Ball, W.J. Jr. (1991. )Investigation of the Lateral and Rotational Motions of the Carbohydrate Chains of the ß Subunit of Na+,K+ ATPase .San Francisco, CA.

Szymanska, G., Amler, E., Ball, W.J. and Kranias, E.G. (1991. )Regulation of Skeletal Sarcoplasmic Reticulum Ca2+ ATPase by Phospholamban and Negatively Charged Phospholipid .San Francisco, CA.

Abbott, A. and Ball, W.J. (1991. )Mechanism of Na+,K+ ATPase Inhibition by mAby M7 PB E9. Cincinnati, OH.

Abbott, A. and Ball, W.J. (1991. )Mechanism of Inhibition of Na+,K+ ATPase by mAb M7 PB E9. Plymouth, N.H..

Sun, Y. and Ball, W.J. (1991. )Localization and Function of antigenic Sites on the ß Subunit of Na+,K+ ATPase. Plymouth, N.H..

Ball, W.J., Abbott, A., Sun, Y. and Malik, B. (1992. )Using Monoclonal Antibodies to Identify and Locate Functional Regions of Na+,K+ ATPase .Cleveland, OH.

Argao, E.A., Bucuvalus, J.C. and Ball, W.J. Jr. (1992. )* and *-Subunit Expression Regulates Hepatic Na+,K+-ATPase Activity in Rat During Development.

Kasturi, R., McLean, L.R., Margolies, M.N., Ball, W.J. Jr. (08-1996. )Anti-digoxin Antibodies as Model Receptors for Cardiac Glycosides. Colorado.

Kasturi, R., McLean, L., Margolies, M., Ball, W.J. (08-1996. )High Affinity Antibodies as Model Receptors for Cardiac Glycosides. Mardel Plata, Argentina.

Ball, W., Norman, A., Tabet, M., Hudson, D., Deo, Y. and Fishwild, D. (04-1998. )Human Monoclonal Antibodies: Generation and Characterization of anti-Drug mAbs .NIDA-Parklawn Bldg..

Norman, A.B., Ball, W.J., Norman, M.K., Tabet, M.R. and Tsibulsky, V.L. (06-2000. )A Cocaine-Selective Monoclonal Antibody Increases the Cocaine Priming Threshold in Rats.

Ball, W.J., Farr, C.D., Tabet, M.R. and Norman, A.B. (2000. )Generation and Identification of Cocaine-Specific Antibodies. Boston, MA.

Rajasekaran, S.A., Palmer, L.G., Ball, W.J., Peralta-Soler, A., Bander, N.H. and Rajasekaran, A.K. (2000. )Multiple functions of -subunit of Na-K-ATPase: Role in epithelial polarization, suppression of invasion and cell motility. San Diego, CA.

Rajasekaran, S.A., Palmer, L.G., Ball, W.J., Peralta-Soler, Bander, N.H. and Rajasekaran, A.K. (2000. )-subunit of Na,K-ATPase is Required for Epithelial Polarization, Suppression of Invasion and cell Motility. San Francisco, CA.

McCann, C.S., Tabet, M.R. and Ball, W.J. (08-2001. )Characterizing Therapeutic Antibodies: Sheep Polyclonal Anti-digoxin and Mouse Monoclonal Anti-cocaine Antibodies. University of Cincinnati College of Medicine.

Ball, W.J., Farr, C., Tabet, M., Burd, C., Wang, X. and Welsh, W. (02-2002. )3-D Quantitative Structure-Activity Relationship Modeling of Digoxin Inhibition of Na+, K+-ATPase. San Francisco, CA.

Paula, S., Tabet, M., Keenan, S., Welsh, W. and Ball, W.J. (05-03-2002. )Mapping the Binding Sites of Two Monoclonal Cocaine-binding Antibodies by Comparative Molecular Field Analysis .University of Cincinnati College of Medicine.

Ball, W.J., Tabet, M., Farr, C., Munson, N. Williams, D., Lonberg, N., Yu, L and Norman, A.B. (06-2002. )Generation and Characterization of a Human Anti-cocaine Antibody. Quebec, Canada.

Ball, W.J., Farr, C., Paula, S., Keenan, S., DeLisle, R. and Welsh, W. (08-2002. )3D Structure-Activity Relationship Modeling of Digoxin Inhibition and Docking to Na+,K+-ATPase. Elsinore, Denmark.

Paula, S., Tabet, M., Farr, C., Norman, A., Keenan, S., Welsh, W. and Ball, W.J. (03-2003. )3D Structure-Activity Relationship Modeling of Cocaine Binding to Monoclonal Antibodies by Comparative Molecular Field Analysis. San Antonio, Texas.

Keenan, S., DeLisle, R., Welsh, W., Kholodovych, V., Paula, S. and Ball, W.J., Jr. (04-2003. )Method for the Discovery of Novel Na,K-ATPase Inhibitors for the Therapeutic Treatment of Cardiovascular Diseases and Conditions. San Diego, CA.

Keenan, S., Kholodovych, V., DeLisle, R., Ball, W.J. and Welsh, W. (03-2003. )Method for the Discovery of Novel Na,K-ATPase Inhibitors for the Therapeutic Treatment of Cardiovascular Diseases and Conditions. New Orleans, LA.

Ball, W., Paula, S., Tabet, M., Farr, C. and Norman, A. (06-2003. )The Molecular Interactions of Cocaine Binding to a Fully Human Monoclonal Antibody. Bal Harbour, FL.

Seligson, D.B., Rajasekaran, S., Yu, H., Liu, X., Shi, T., Eeva, M., Horvath, S., Ball, W.J. Jr.,and Rajasekaran, A. K. (2004. )Na, K-ATPase alpha and beta Subunits Protein Expression as Clinical Prognosticators in Kidney Cancer. Orlando, FL.

Ball, W., Tabet, M. and Paula, S. (07-2005. )Structure-Activity Relationship Models for Cardiac Glycoside Binding and for ATPase Inhibition of the Na,K-ATPase. Budapest Hungary.

Ball, W. J., Paula, S., Tabet, M. R., Norman, M.K. and Norman, A. B. (06-2006. )Developing an Immuno-Therapy for Relapse Prevention in Cocaine Abuse. Istanbul, Turkey.

Tabet, M. R., Ball, W. J. and Norman, A. B. (06-2006. )Pharmacological and Toxicological Screening of a Chimeric Human anti-cocaine Monoclonal Antibody. .Scottsdale, Arizona.

Norman, A. B., Tabet, M. R., Norman, M. K., Buesing, W. R., Pesce, A. J., Tsibulsky, V. L. and Ball, W. J. (06-2006. )A Chimeric Human Anti-cocaine Monoclonal Antibody Alters the Distribution but not the Metabolism of Cocaine in Mice. Scottsdale, Arizona.

Norman, A.B., Norman, M.K., Buesing, W.R., Tabet, M.R., Tsibulsky, V.L. and Ball, W.J. (06-2007. )A Chimeric Human Anti-cocaine Monoclonal Antibody Antagonizes the Cocaine-induced Priming of Self-administration in Rats. Quebec City, Canada.

Norman, A. B., Norman, M. K., Tabet, M. R., Buesing, W. R. and Ball, W. J. (2008. )A New Treatment for Cocaine Abuse. San Diego, CA.

Honors and Awards

2001 Faculty Development Award; Interdisciplinary

1999 Faculty Development Award; Individual Award

1984 -1989 American Heart Association, Established Investigators Award

1977 -1978 PHS National Service Award

1975 American Cancer Society Institutional Grant Award

1973 NCI Postdoctoral Fellowship

NIH Predoctoral Traineeship

NSF Undergraduate Research Fellowship

Service

(Department Appointments, Reappointments, Promotions & Tenure Committee (2003-2008, Committe Chair, 2006-08) )

(Space Committee (2003-06) )

(Steering Committee (2003-07) )

(Departmental Reappointments, Promotions and Tenure Comm. (1983-1988; 1993; 1995-1997) )

(Departmental Representative to Faculty Forum Committee (1980’s & 1996-1998) )

(Master's Degree Thesis Committee Member: Wilhelm Kossenjans, Dept. of Pathology )

(Graduate Student Qualifying Exam Committee: Ms. Amy Atzel, Ms. Sheryl Koch, Ms. Deborah Rathz, Mr. Mark Williams, Mr. James Hall, Mr. Terry Wright, Ms. Jian Xu, Ms. Kimberly Gregory (WJB, Chair), Ms. Siyun Liao (WJB, Chair), Ms. Min Dong, Mr. Michael Wilhide, Mr. Keith Gaddie, Ms. Shan Chen )

(Ph.D. Thesis Research Committee Member: Daniel Prows, Dept. Pharmacy, Univ. Cincinnati (1995), Stephanie Lewis Carl, Dept. Molecular & Cellular, Physiology, Univ. Cincinnati (1996) Nane Saruazyan, Dept. Pharm., Med. Coll. Ohio, Toledo (1996), Saadia Ahmed, Dept. Pharm., Univ. Cincinnati (1998) )

(Departmental Merit Pay Guidelines Committee (1987, 1988) )

(Advisory Committee, Office of Geriatric Medicine (1993) )

(APT Criteria Guidelines Review Committee (1990) )

(Graduate Education Committee (1994) )

(Director of PPG Service Core 6: Immunology/Monoclonol Antibodies (1988 1993) )

(Department Executive Committee (1993) )

(Department Finance Analysis Committee (1992) )

(Finance Management Committee (1992-1994) )

(Academic Challenge Program Committee (1990-1994) )

(Department Seminar Program, Director (1996-1998) )

(All-University Faculty Grievance Committee (2007-present) )

(Faculty Senate Budget and Priorites Committee (2008) )

(AAUP Executive Council, Associate Rep COM (2008) )

(Office of Sponsored Programs (OSP) Advisory Committee (Fall 1998-2003) )

(College of Pharmacy - Faculty Search Committee, Member (Fall 2001-2002) )

(SPIRCAP Project Management Committee, Co-chair (1998-2003) )

(Grievance Committee, College of Medicine (1985-1986) )

(College of Medicine Committees: Biomedical Res. Support Grant Comm. (1989 92) )

(Graduate Student Res. Forum, Science Judge for Coll. of Med. Program (1989; 1990) )

(Member, Medical Student Research Committee (1995-1999) )

(Member NIH Study Sections: Special Emphasis Section ZRG1 BST “Assays and Methods Development (2004-present); and Section ZDA “Instrumentation and Systems Development” (2007-present); Ad hoc member NIH/NIDA Councils: RFA: Development of Immunotherapeutic Treatment of Methamphetamine Abuse (2007); NIDA-K 1 Special Emphasis Panel/Scientific Review Panel (2007) and, NIAAA; AA-11 “Alcohol & Alcoholism Council (2006, 2008) )

(Reviewer CINSAM Proposals- Northern Kentucky Univ. (2006) )

(Grant Reviewer for Research Corporation: Cottrell College Science Award (2005) )

(Czech Science Foundation (2005) )

(Grant Reviewer for "2001 Cooperative Grants Program of the U.S. Civilian Research and Development Foundation (CRDF)” )

(NSF, Research Experiences for Undergraduate Program grants (2001-02) )

(Ad Hoc Reviewer for NIH Program Project Grant Site Visit (1991) )

(Ad Hoc Reviewer of NSF proposals for Division of Molecular & Cellular Biosciences Program (1993-97) )

(Grant Reviews for The Israel Science Foundation (1994) )

(American Heart Association: Reviewer for the Ohio and Southwestern Ohio Affiliate Committees (1984-1992) )

Keywords

Biochemistry,Biophysical Chemistry,Molecular Biology,Enzyme,Enzyme Mechanism,Glycoprotein,Protein Chemistry,Protein Structure,Membrane Transport,Receptor,Antibody,Antigen,Site,Drug Action

Professional Affiliation

11-2002 -05-2003: Training Courses: Introduction to Structure based design & Protein Modeling Techniques, Tripos, Inc. St. Louis, MO

03-20-2000 -03-24-2000: Training Course: Principles and Applications of Time-Resolved Spectroscopy, Director Dr. J. Lakowicz, University Maryland, School of Medicine, Baltimore

1994 -1995: Visiting Scientist, 7 months: The Scripps Research Institute, La Jolla, California: Laboratory of Drs. Richard Lerner and Carlos Barbas, Department of Molecular Biology. During this Sabbatical leave, I gained experience in molecular biology techniques and the use of bacteriophage-displayed combinatorial antibody libraries.

1977 -1978: Visiting Immunology Trainee, 6 months: Columbia University, College of Physicians and Surgeons, New York, New York. As a Visiting Trainee (PHS National Service Award), I gained my initial experience in immunological techniques under the guidance of Dr. Vincent P. Butler.

Courses Taught

Drugs and Pulmonary Disease

Pulmonary Drugs Laboratory

Immunopharmacology

Antifungal Agents

Antihistamine Drugs

Medical Pharmacology Course – Case Studies with small groups

Pharmacology Graduate Course "Applications of Immunochemical Techniques for Light and Electron Microscopy"

Pharmacology Graduate Course lectures on "Antibody Cell Membrane Protein Interactions"

Chemistry Department: Biochemistry Course 601: (Co-Director with Mark Friedman) Topics: Nucleic Acids: Molecular Biology.

Experimental Methods in Pharmacology: Lectures in Immunochemistry.

Lecturer: College of Pharmacy Course "Fluorescence Techniques in Pharmacology,"

Molecular & Cellular Pharmacology Graduate Course: Topic: "Histamine Receptors" (‘98-2002)

Receptor Pharmacology Course: "Introduction to Pharmacokinetics" ('01-continuing) 2 hr/lecture "Spectroscopic Analysis of Receptors and Ligand Binding" ('01-05) “Histamine Receptors” (05- con’t ) 2 hr/lecture.

University of Cincinnati Graduate Faculty, Member, and Faculty Participant in the Medical Sciences Scholars Program

Contact Information

Academic - Cardiovascular Center
Room CVC 5939
Cincinnati  Ohio, 4526700575
Phone: 513-558-2388
Fax: 513-558-9969
william.ball@uc.edu