Richard  Becker

Richard Clinton Becker

Professor of Medicine, University of Cincinnati College of Medicine; Director and Physician-in-Chief, UC Heart, Lung and Vascular Institute

Cardiovascular Rsrch Cntr

4936

COM IM Cardiology Division - 0542

University of Cincinnati College of Medicine
231 Albert Sabin Way
Cincinnati, Ohio 45267

Professional Summary

Stonehill Endowed Chair and Professor of Medicine, University of Cincinnati College of Medicine
Chief, Division of Cardiovascular Health and Disease
Director and Physician-in-Chief, UC Heart, Lung and Vascular Institute

Education

Medical Degree, University of Cincinnati College of Medicine 1982

Residency, Internal Medicine, Cleveland Clinic Foundation Cleveland, OH,

Fellowship, Cardiovascular Disease, University of Massachusetts Medical School Worcester, MA,

Positions and Work Experience

- Founding Director, Thrombosis Center, Bench, translational and clinical research, University of Massachusetts Medical School,

- Director, Cardiovascular Thrombosis Center, NIH-supported Translational Science, Duke University,

- Director, Heart, Lung and Vascular Institute, Basic, translation and clinical research, University of Cincinnati College of Medicine,

Research and Practice Interests

Research focuses on platelets, coagulation proteins, nucleic acids, cell-free DNA-histone complexes and oligonucleotides as reversible antithrombotic agents.

UC Health Clinical Focus

Cardiology

Cardiovascular Disease

UC Health Specialities

Cardiovascular Disease

Internal Medicine

Certifications

American Board of Internal Medicine

09/10/1986

Research Support

Grant: #U01HL0807229 Investigators:Ortel, Becker NHLBI BRIDGE Trial Role:Co-PI

Grant: #R01-HL065222 Investigators:Sullenger, Becker NHLBI Antithrombotic Aptamers and Antidotes Role:Co-investigator Active Type:Grant Level:National

Grant: #P01-HL036587 Investigators:Williams, Becker NIH genetic and Environmental influences on the expression of CVD endophenotypes Role:Project PI

Grant: #U54-HL112307 Investigators:Becker NHLBI Translational Research centers for Thrombotic and hemostatic Disorders Role:PI

Grant: #U54-HL112307 Investigators:Becker NHLBI TRC-THD Administrative Coordinating Center Role:PI Active Type:Grant

Grant: #2033678 / P01 HL036587 Investigators:Becker, Richard 10-01-2013 -03-31-2015 National Heart, Lung and Blood Institute Genes, Environmental Stressors and the Biobehavioral Pathways to CHD Role:PI $3,725.00 Awarded Level:Federal

Grant: #203-9572 / U54 HL112307 Investigators:Becker, Richard 05-01-2013 -04-30-2014 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders-ACC Role:PI $6,596.00 Active Level:Federal

Grant: #203-2902 / U54 HL112307 Project 2 Investigators:Becker, Richard 05-01-2013 -04-30-2014 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders - Project 2 Role:PI $19,778.00 Active Level:Federal

Grant: #203-8552_U01 HL087229 Investigators:Becker, Richard 10-01-2013 -03-31-2015 National Heart, Lung and Blood Institute Bridging Anticoagulant Therapy in Patients who Require Temporary Interruption of Wafarin Therapy for an Elective Invasive Procedure of Surgery Role:PI $1,330.00 Active Level:Federal

Grant: #203-8668 / U01 HL087229 Investigators:Becker, Richard 04-01-2014 -03-31-2015 National Heart, Lung and Blood Institute Bridging Anticoagulant Therapy in Patients who Require Temporary Interruption of Wafarin Therapy for an Elective Invasive Procedure of Surgery Role:PI $2,699.00 Active Level:Federal

Grant: #203-9854 / U54 HL112307 Investigators:Becker, Richard 05-01-2014 -04-30-2015 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders-ACC Year 3 Role:PI $8,472.36 Active Level:Federal

Grant: #203-9209 / U54 HL112307 Investigators:Becker, Richard 05-01-2014 -04-30-2015 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders - Project 2, Year 3 Role:PI $33,889.00 Active Level:Federal

Grant: #203-8833 / U54 HL112307 Investigators:Becker, Richard 05-01-2015 -04-30-2016 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders-ACC Year 3 Role:PI $8,487.00 Active Level:Federal

Grant: #203-4543 / U54 HL112307 Investigators:Becker, Richard 05-01-2015 -04-30-2016 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders - Project 2, Year 3 Role:PI $33,948.00 Active Level:Federal

Grant: #135713/15SFRN24110000 Investigators:Becker, Richard 04-01-2015 -03-31-2019 American Heart Association - National Chapter Study of Hypertension in Pediatrics - Adult Hypertension Onset in Youth (SHIP AHOY) Role:PI $68,772.00 Active Level:Private Non-Profit

Grant: #Duke sub R01 HL065222 Investigators:Becker, Richard 09-01-2015 -03-31-2019 National Heart, Lung and Blood Institute Antithrombotic Aptamers and Antidotes Role:PI $6,979.00 Active Level:Federal

Grant: #Duke 203-5242 P2 / U54 HL112307 Investigators:Becker, Richard 05-01-2016 -04-30-2017 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders - Project 2, Year 4 Role:PI $61,576.00 Active Level:Federal

Grant: #Duke 203-8193_ACC / U54 HL112307 Investigators:Becker, Richard 05-01-2016 -04-30-2017 National Heart, Lung and Blood Institute Translational Research Centers in Thrombotic & Hemostatic Disorders-ACC, Year 4 Role:PI $15,394.00 Active Level:Federal

Grant: #CV185-764 Investigator Sponsored Research Agreement Investigators:Arduser, Lora; Becker, Richard; Cogorno, Steven; Costanzo, Amy; Costea, Alexandru; Dixon, Estrelita; Eckman, Mark; Flaherty, Matthew; Harnett, Brett; Kleindorfer, Dawn; Kues, John; Leonard, Anthony; Schauer, Daniel 01-01-2020 -12-31-2021 Bristol-Myers Squibb Co. EHR embedded Decision Support Tool to Prevent Stroke in AF Role:Collaborator $414,724.31 Awarded Level:Industry

Publications

Peer Reviewed Publications

Piccini, Jonathan P; Garg, Jyotsna; Patel, Manesh R; Lokhnygina, Yuliya; Goodman, Shaun G; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Nessel, Christopher C; Mahaffey, Kenneth W; Singer, Daniel E; Califf, Robert M; Fox, Keith A A (2014. )Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial.European heart journal, ,35 (28 ),1873-80

Halperin, Jonathan L; Hankey, Graeme J; Wojdyla, Daniel M; Piccini, Jonathan P; Lokhnygina, Yuliya; Patel, Manesh R; Breithardt, Günter; Singer, Daniel E; Becker, Richard C; Hacke, Werner; Paolini, John F; Nessel, Christopher C; Mahaffey, Kenneth W; Califf, Robert M; Fox, Keith A A (2014. )Efficacy and Safety of Rivaroxaban Compared With Warfarin Among Elderly Patients With Nonvalvular Atrial Fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).Circulation, ,130 (2 ),138-46

Smiley, Dia A; Becker, Richard C (2014. )Factor IXa as a target for anticoagulation in thrombotic disorders and conditions.Drug discovery today, ,

Akerblom, Axel; Eriksson, Niclas; Wallentin, Lars; Siegbahn, Agneta; Barratt, Bryan J; Becker, Richard C; Budaj, Andrzej; Himmelmann, Anders; Husted, Steen; Storey, Robert F; Johansson, Asa; James, Stefan K (2014. )Polymorphism of the cystatin C gene in patients with acute coronary syndromes: Results from the PLATelet inhibition and patient Outcomes study.American heart journal, ,168 (1 ),96-102.e2

Wallentin, Lars; Becker, Richard C; Cannon, Christopher P; Held, Claes; Himmelmann, Anders; Husted, Steen; James, Stefan K; Katus, Hugo A; Mahaffey, Kenneth M; Pieper, Karen S; Storey, Robert F; Steg, Philippe Gabriel; Harrington, Robert A (2014. )No misrepresentation of vital status follow-up in PLATO: Predefined analyses guarantee the integrity of the benefits of ticagrelor over clopidogrel in the PLATO trial: Commentary on: DiNicolantonio JJ, Tomek A, Misrepresentation of vital status follow-up: Challenging the integrity of the PLATO trial and the claimed mortality benefit of ticagrelor versus clopidogrel, International Journal of Cardiology, 2013 Serebruany VL. Discrepancies in the primary PLATO trial publication and the FDA reviews, International Journal of Cardiology, 2014.International journal of cardiology, ,

Welsby, Ian J; Phillips-Bute, Barbara; Mathew, Joseph P; Newman, Mark F; Becker, Richard; Rao, Sunil; Milano, Carmelo A; Stafford-Smith, Mark (2014. )ABO blood group influences transfusion and survival after cardiac surgery.Journal of thrombosis and thrombolysis, ,

Povsic, Thomas J; Vavalle, John P; Alexander, John H; Aberle, Laura H; Zelenkofske, Steven L; Becker, Richard C; Buller, Christopher E; Cohen, Mauricio G; Cornel, Jan H; Kasprzak, Jaroslaw D; Montalescot, Gilles; Fail, Peter S; Sarembock, Ian J; Mehran, Roxana (2014. )Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the phase II RADAR-PCI study.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, ,

Husted, Steen; James, Stefan K; Bach, Richard G; Becker, Richard C; Budaj, Andrzej; Heras, Magda; Himmelmann, Anders; Horrow, Jay; Katus, Hugo A; Lassila, Riita; Morais, Joao; Nicolau, José C; Steg, Ph Gabriel; Storey, Robert F; Wojdyla, Daniel; Wallentin, Lars (2014. )The efficacy of ticagrelor is maintained in women with acute coronary syndromes participating in the prospective, randomized, PLATelet inhibition and patient Outcomes (PLATO) trial.European heart journal, ,35 (23 ),1541-50

Steinberg, Benjamin A; Hellkamp, Anne S; Lokhnygina, Yuliya; Halperin, Jonathan L; Breithardt, Günter; Passman, Rod; Hankey, Graeme J; Patel, Manesh R; Becker, Richard C; Singer, Daniel E; Hacke, Werner; Berkowitz, Scott D; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M; Piccini, Jonathan P (2014. )Use and outcomes of antiarrhythmic therapy in patients with atrial fibrillation receiving oral anticoagulation: results from the ROCKET AF trial.Heart rhythm : the official journal of the Heart Rhythm Society, ,11 (6 ),925-32

Wong, Ka Sing Lawrence; Hu, Dai Yi; Oomman, Abraham; Tan, Ru-San; Patel, Manesh R; Singer, Daniel E; Breithardt, Günter; Mahaffey, Kenneth W; Becker, Richard C; Califf, Robert; Fox, Keith A A; Berkowitz, Scott D; Hacke, Werner; Hankey, Graeme J (2014. )Rivaroxaban for stroke prevention in East Asian patients from the ROCKET AF trial.Stroke; a journal of cerebral circulation, ,45 (6 ),1739-47

Voora, Deepak; Becker, Richard C (2014. )A freeze on tailored antiplatelet therapy?.Circulation, ,129 (21 ),2088-90

Patel, Manesh R; Becker, Richard C; Wojdyla, Daniel M; Emanuelsson, Hakan; Hiatt, William R; Horrow, Jay; Husted, Steen; Mahaffey, Kenneth W; Steg, P Gabriel; Storey, Robert F; Wallentin, Lars; James, Stefan K (2014. )Cardiovascular events in acute coronary syndrome patients with peripheral arterial disease treated with ticagrelor compared with clopidogrel: Data from the PLATO Trial.European journal of preventive cardiology, ,

Sherwood, Matthew W; Douketis, James D; Patel, Manesh R; Piccini, Jonathan P; Hellkamp, Anne S; Lokhnygina, Yuliya; Spyropoulos, Alex C; Hankey, Graeme J; Singer, Daniel E; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M; Becker, Richard C (2014. )Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF).Circulation, ,129 (18 ),1850-9

Storey, Robert F; Kotha, Jayaprakash; Smyth, Susan S; Moliterno, David J; Rorick, Tyrus L; Moccetti, Tiziano; Valgimigli, Marco; Dery, Jean Pierre; Cornel, Jan H; Thomas, Gregory S; Huber, Kurt; Harrington, Robert A; Hord, Edward; Judge, Heather M; Chen, Edmond; Strony, John; Mahaffey, Kenneth W; Tricoci, Pierluigi; Becker, Richard C; Jennings, Lisa K (2014. )Effects of vorapaxar on platelet reactivity and biomarker expression in non-ST-elevation acute coronary syndromes. The TRACER Pharmacodynamic Substudy.Thrombosis and haemostasis, ,111 (5 ),883-91

Daly, Patrick L; Becker, Richard C (2014. )Pharmacogenetics of antiplatelet therapy.Current atherosclerosis reports, ,16 (5 ),411

Ahmad, Tariq; Becker, Richard C (2014. )The unmet need for philanthropic funding of early career cardiovascular investigators.Journal of thrombosis and thrombolysis, ,37 (4 ),527-31

Hankey, Graeme J; Stevens, Susanna R; Piccini, Jonathan P; Lokhnygina, Yuliya; Mahaffey, Kenneth W; Halperin, Jonathan L; Patel, Manesh R; Breithardt, Günter; Singer, Daniel E; Becker, Richard C; Berkowitz, Scott D; Paolini, John F; Nessel, Christopher C; Hacke, Werner; Fox, Keith A A; Califf, Robert M (2014. )Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation.Stroke; a journal of cerebral circulation, ,45 (5 ),1304-12

Mahaffey, Kenneth W; Held, Claes; Wojdyla, Daniel M; James, Stefan K; Katus, Hugo A; Husted, Steen; Steg, Philippe Gabriel; Cannon, Christopher P; Becker, Richard C; Storey, Robert F; Khurmi, Nardev S; Nicolau, José C; Yu, Cheuk-Man; Ardissino, Diego; Budaj, Andrzej; Morais, Joao; Montgomery, Debra; Himmelmann, Anders; Harrington, Robert A; Wallentin, Lars (2014. )Ticagrelor effects on myocardial infarction and the impact of event adjudication in the PLATO (Platelet Inhibition and Patient Outcomes) trial.Journal of the American College of Cardiology, ,63 (15 ),1493-9

Piccini, Jonathan P; Hellkamp, Anne S; Lokhnygina, Yuliya; Patel, Manesh R; Harrell, Frank E; Singer, Daniel E; Becker, Richard C; Breithardt, Günter; Halperin, Jonathan L; Hankey, Graeme J; Berkowitz, Scott D; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M (2014. )Relationship between time in therapeutic range and comparative treatment effect of rivaroxaban and warfarin: results from the ROCKET AF trial.Journal of the American Heart Association, ,3 (2 ),e000521

Abo-Salem, Elsayed; Becker, Richard (2014. )Transitioning to and from the novel oral anticoagulants: a management strategy for clinicians.Journal of thrombosis and thrombolysis, ,37 (3 ),372-9

Steinhubl, Steven R; Eikelboom, John W; Hylek, Elaine M; Dauerman, Harold L; Smyth, Susan S; Becker, Richard C (2014. )Antiplatelet therapy in prevention of cardio- and venous thromboembolic events.Journal of thrombosis and thrombolysis, ,37 (3 ),362-71

Goodman, Shaun G; Wojdyla, Daniel M; Piccini, Jonathan P; White, Harvey D; Paolini, John F; Nessel, Christopher C; Berkowitz, Scott D; Mahaffey, Kenneth W; Patel, Manesh R; Sherwood, Matthew W; Becker, Richard C; Halperin, Jonathan L; Hacke, Werner; Singer, Daniel E; Hankey, Graeme J; Breithardt, Gunter; Fox, Keith A A; Califf, Robert M (2014. )Factors associated with major bleeding events: insights from the ROCKET AF trial (rivaroxaban once-daily oral direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation).Journal of the American College of Cardiology, ,63 (9 ),891-900

Becker, Richard C (2014. )Editor's page.Journal of thrombosis and thrombolysis, ,37 (2 ),216

Wallentin, Lars; Lindholm, Daniel; Siegbahn, Agneta; Wernroth, Lisa; Becker, Richard C; Cannon, Christopher P; Cornel, Jan H; Himmelmann, Anders; Giannitsis, Evangelos; Harrington, Robert A; Held, Claes; Husted, Steen; Katus, Hugo A; Mahaffey, Kenneth W; Steg, Ph Gabriel; Storey, Robert F; James, Stefan K (2014. )Biomarkers in relation to the effects of ticagrelor in comparison with clopidogrel in non-ST-elevation acute coronary syndrome patients managed with or without in-hospital revascularization: a substudy from the Prospective Randomized Platelet Inhibition and Patient Outcomes (PLATO) trial.Circulation, ,129 (3 ),293-303

Wallentin, Lars; Becker, Richard C; Cannon, Christopher P; Held, Claes; Himmelmann, Anders; Husted, Steen; James, Stefan K; Katus, Hugo S; Mahaffey, Kenneth W; Pieper, Karen S; Storey, Robert F; Steg, Philippe Gabriel; Harrington, Robert A (2014. )Review of the accumulated PLATO documentation supports reliable and consistent superiority of ticagrelor over clopidogrel in patients with acute coronary syndrome: Commentary on: DiNicolantonio JJ, Tomek A, Inactivations, deletions, non-adjudications, and downgrades of clinical endpoints on ticagrelor: serious concerns over the reliability of the PLATO trial, International Journal of Cardiology, 2013.International journal of cardiology, ,170 (3 ),e59-62

Xu, Weixian; Holmes, Dajuanicia N; Becker, Richard C; Roe, Matthew T; Peterson, Eric D; Wang, Tracy Y (2013. )Comparison of long-term outcomes between older Asian and white patients with non-ST-segment elevation myocardial infarction: findings from CRUSADE-CMS database.American heart journal, ,166 (6 ),1050-5

Vavalle, John P; Povsic, Thomas J; Aberle, Laura H; Zelenkofske, Steven L; Mehran, Roxana; Kasprzak, Jaroslaw D; Bode, Christoph; Buller, Christopher E; Montalescot, Gilles; Cornel, Jan H; Becker, Richard C; Alexander, John H; Cohen, Mauricio G (2013. )Safety of very early sheath removal in patients treated with REG1 for acute coronary syndromes: insights from the RADAR trial. The Journal of invasive cardiology, ,25 (11 ),593-9

Brummett, Beverly H; Babyak, Michael A; Jiang, Rong; Shah, Svati H; Becker, Richard C; Haynes, Carol; Chryst-Ladd, Megan; Craig, Damian M; Hauser, Elizabeth R; Siegler, Ilene C; Kuhn, Cynthia M; Singh, Abanish; Williams, Redford B (2013. )A functional polymorphism in the 5HTR2C gene associated with stress responses also predicts incident cardiovascular events.PloS one, ,8 (12 ),e82781

Voora, Deepak; Cyr, Derek; Lucas, Joseph; Chi, Jen-Tsan; Dungan, Jennifer; McCaffrey, Timothy A; Katz, Richard; Newby, L Kristin; Kraus, William E; Becker, Richard C; Ortel, Thomas L; Ginsburg, Geoffrey S (2013. )Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events.Journal of the American College of Cardiology, ,62 (14 ),1267-76

Åkerblom, Axel; Wallentin, Lars; Larsson, Anders; Siegbahn, Agneta; Becker, Richard C; Budaj, Andrzej; Himmelmann, Anders; Horrow, Jay; Husted, Steen; Storey, Robert F; Asenblad, Nils; James, Stefan K (2013. )Cystatin C- and creatinine-based estimates of renal function and their value for risk prediction in patients with acute coronary syndrome: results from the PLATelet Inhibition and Patient Outcomes (PLATO) study.Clinical chemistry, ,59 (9 ),1369-75

Jackson, Larry R; Becker, Richard C (2013. )Novel oral anticoagulants: pharmacology, coagulation measures, and considerations for reversal.Journal of thrombosis and thrombolysis, ,

Povsic, Thomas J; Vavalle, John P; Aberle, Laura H; Kasprzak, Jaroslaw D; Cohen, Mauricio G; Mehran, Roxana; Bode, Christoph; Buller, Christopher E; Montalescot, Gilles; Cornel, Jan H; Rynkiewicz, Andrzej; Ring, Michael E; Zeymer, Uwe; Natarajan, Madhu; Delarche, Nicolas; Zelenkofske, Steven L; Becker, Richard C; Alexander, John H (2013. )A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial.European heart journal, ,34 (31 ),2481-9

James, Stefan K; Storey, Robert F; Pieper, Karen S; Cannon, Christopher P; Becker, Richard C; Steg, Philippe Gabriel; Wallentin, Lars; Harrington, Robert A (2013. )Response to letter regarding article, "Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials".Stroke; a journal of cerebral circulation, ,44 (8 ),e95-6

Mentz, Robert J; Becker, Richard C (2013. )Funding opportunities for clinical investigators in the early stages of career development in cardiovascular research.Journal of thrombosis and thrombolysis, ,

Dewald, Tracy A; Becker, Richard C (2013. )The pharmacology of novel oral anticoagulants.Journal of thrombosis and thrombolysis, ,

Mahaffey, Kenneth W; Wojdyla, Daniel; Hankey, Graeme J; White, Harvey D; Nessel, Christopher C; Piccini, Jonathan P; Patel, Manesh R; Berkowitz, Scott D; Becker, Richard C; Halperin, Jonathan L; Singer, Daniel E; Califf, Robert M; Fox, Keith A A; Breithardt, Günter; Hacke, Werner (2013. )Clinical outcomes with rivaroxaban in patients transitioned from vitamin K antagonist therapy: a subgroup analysis of a randomized trial.Annals of internal medicine, ,158 (12 ),861-8

Rodés-Cabau, Josep; Dauerman, Harold L; Cohen, Mauricio G; Mehran, Roxana; Small, Eric M; Smyth, Susan S; Costa, Marco A; Mega, Jessica L; O'Donoghue, Michelle L; Ohman, E Magnus; Becker, Richard C (2013. )Antithrombotic Treatment in Transcatheter Aortic Valve Implantation: Insights for Cerebrovascular and Bleeding Events.Journal of the American College of Cardiology, ,

Singer, Daniel E; Hellkamp, Anne S; Piccini, Jonathan P; Mahaffey, Kenneth W; Lokhnygina, Yuliya; Pan, Guohua; Halperin, Jonathan L; Becker, Richard C; Breithardt, Günter; Hankey, Graeme J; Hacke, Werner; Nessel, Christopher C; Patel, Manesh R; Califf, Robert M; Fox, Keith A A (2013. )Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial.Journal of the American Heart Association, ,2 (1 ),e000067

Patel, Manesh R; Hellkamp, Anne S; Lokhnygina, Yuliya; Piccini, Jonathan P; Zhang, Zhongxin; Mohanty, Surya; Singer, Daniel E; Hacke, Werner; Breithardt, Günter; Halperin, Jonathan L; Hankey, Graeme J; Becker, Richard C; Nessel, Christopher C; Berkowitz, Scott D; Califf, Robert M; Fox, Keith A A; Mahaffey, Kenneth W (2013. )Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation).Journal of the American College of Cardiology, ,61 (6 ),651-8

Becker, Richard C (2013. )A thought experiment in contemporary drug development: informed bench-to-bedside strategies.Journal of the American Heart Association, ,2 (1 ),e000031

Bernacki, Gwen M; Becker, Richard C (2013. )Oral anticoagulants in older adults with atrial fibrillation.Journal of thrombosis and thrombolysis, ,

Piccini, Jonathan P; Stevens, Susanna R; Chang, YuChiao; Singer, Daniel E; Lokhnygina, Yuliya; Go, Alan S; Patel, Manesh R; Mahaffey, Kenneth W; Halperin, Jonathan L; Breithardt, Günter; Hankey, Graeme J; Hacke, Werner; Becker, Richard C; Nessel, Christopher C; Fox, Keith A A; Califf, Robert M (2013. )Renal dysfunction as a predictor of stroke and systemic embolism in patients with nonvalvular atrial fibrillation: validation of the R(2)CHADS(2) index in the ROCKET AF (Rivaroxaban Once-daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) and ATRIA (AnTicoagulation and Risk factors In Atrial fibrillation) study cohorts.Circulation, ,127 (2 ),224-32

Krishnan, Anandi; Vogler, Erwin A; Sullenger, Bruce A; Becker, Richard C (2013. )The effect of surface contact activation and temperature on plasma coagulation with an RNA aptamer directed against factor IXa.Journal of thrombosis and thrombolysis, ,35 (1 ),48-56

Berger, Jeffrey S; Becker, Richard C; Kuhn, Cynthia; Helms, Michael J; Ortel, Thomas L; Williams, Redford (2013. )Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation.Thrombosis and haemostasis, ,109 (1 ),85-92

Chan, Mark Y; Lin, Min; Lucas, Joseph; Moseley, Arthur; Thompson, J Will; Cyr, Derek; Ueda, Hitoshi; Kajikawa, Mariko; Ortel, Thomas L; Becker, Richard C (2012. )Plasma proteomics of patients with non-valvular atrial fibrillation on chronic anti-coagulation with warfarin or a direct factor Xa inhibitor.Thrombosis and haemostasis, ,108 (6 ),1180-91

Husted, Steen; James, Stefan; Becker, Richard C; Horrow, Jay; Katus, Hugo; Storey, Robert F; Cannon, Christopher P; Heras, Magda; Lopes, Renato D; Morais, Joao; Mahaffey, Kenneth W; Bach, Richard G; Wojdyla, Daniel; Wallentin, Lars (2012. )Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial.Circulation. Cardiovascular quality and outcomes, ,5 (5 ),680-8

Angiolillo, Dominick J; Schneider, David J; Bhatt, Deepak L; French, William J; Price, Matthew J; Saucedo, Jorge F; Shaburishvili, Tamaz; Huber, Kurt; Prats, Jayne; Liu, Tiepu; Harrington, Robert A; Becker, Richard C (2012. )Pharmacodynamic effects of cangrelor and clopidogrel: the platelet function substudy from the cangrelor versus standard therapy to achieve optimal management of platelet inhibition (CHAMPION) trials.Journal of thrombosis and thrombolysis, ,34 (1 ),44-55

Wisler, James W; Becker, Richard C (2012. )A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation.Critical pathways in cardiology, ,11 (2 ),55-61

Rowley, Jesse W; Finn, Aloke V; French, Patricia A; Jennings, Lisa K; Bluestein, Danny; Gross, Peter L; Freedman, Jane E; Steinhubl, Steven R; Zimmerman, Guy A; Becker, Richard C; Dauerman, Harold L; Smyth, Susan S (2012. )Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses.Circulation. Cardiovascular interventions, ,5 (2 ),296-304

Wisler, James W; Washam, Jeffrey B; Becker, Richard C (2012. )Evaluation of dose requirements for prolonged bivalirudin administration in patients with renal insufficiency and suspected heparin-induced thrombocytopenia.Journal of thrombosis and thrombolysis, ,33 (3 ),287-95

Hankey, Graeme J; Patel, Manesh R; Stevens, Susanna R; Becker, Richard C; Breithardt, Günter; Carolei, Antonio; Diener, Hans-Christoph; Donnan, Geoffrey A; Halperin, Jonathan L; Mahaffey, Kenneth W; Mas, Jean-Louis; Massaro, Ayrton; Norrving, Bo; Nessel, Christopher C; Paolini, John F; Roine, Risto O; Singer, Daniel E; Wong, Lawrence; Califf, Robert M; Fox, Keith A A; Hacke, Werner (2012. )Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF.Lancet neurology, ,11 (4 ),315-22

Chan, Mark Y; Tan, Karen; Tan, Huay-Cheem; Huan, Pei-Tee; Li, Bei; Phua, Qian-Hui; Lee, Hong-Kai; Lee, Chi-Hang; Low, Adrian; Becker, Richard C; Ong, Wen-Chong; Richards, Mark A; Salim, Agus; Tai, E-Shyong; Koay, Evelyn (2012. )CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese, Malay and Indian subjects.Pharmacogenomics, ,13 (5 ),533-42

Wisler, James W; Becker, Richard C (2012. )Oral factor Xa inhibitors for the long-term management of ACS.Nature reviews. Cardiology, ,9 (7 ),392-401

Nimjee, Shahid M; Lohrmann, Jens D; Wang, Haichen; Snyder, David J; Cummings, Thomas J; Becker, Richard C; Oney, Sabah; Sullenger, Bruce A (2012. )Rapidly regulating platelet activity in vivo with an antidote controlled platelet inhibitor.Molecular therapy : the journal of the American Society of Gene Therapy, ,20 (2 ),391-7

Akerblom, Åxel; Wallentin, Lars; Siegbahn, Agneta; Becker, Richard C; Budaj, Andrzej; Buck, Kristen; Giannitsis, Evangelos; Horrow, Jay; Husted, Steen; Katus, Hugo A; Steg, Philippe Gabriel; Storey, Robert F; Åsenblad, Nils; James, Stefan K (2012. )Cystatin C and estimated glomerular filtration rate as predictors for adverse outcome in patients with ST-elevation and non-ST-elevation acute coronary syndromes: results from the Platelet Inhibition and Patient Outcomes study.Clinical chemistry, ,58 (1 ),190-9

Storey, Robert F; Becker, Richard C; Harrington, Robert A; Husted, Steen; James, Stefan K; Cools, Frank; Steg, Philippe Gabriel; Khurmi, Nardev S; Emanuelsson, Hakan; Lim, Soo Teik; Cannon, Christopher P; Katus, Hugo A; Wallentin, Lars (2011. )Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patient Outcomes [PLATO] pulmonary function substudy).The American journal of cardiology, ,108 (11 ),1542-6

Storey, Robert F; Becker, Richard C; Harrington, Robert A; Husted, Steen; James, Stefan K; Cools, Frank; Steg, Philippe Gabriel; Khurmi, Nardev S; Emanuelsson, Håkan; Cooper, Anna; Cairns, Richard; Cannon, Christopher P; Wallentin, Lars (2011. )Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes.European heart journal, ,32 (23 ),2945-53

Fox, Keith A A; Piccini, Jonathan P; Wojdyla, Daniel; Becker, Richard C; Halperin, Jonathan L; Nessel, Christopher C; Paolini, John F; Hankey, Graeme J; Mahaffey, Kenneth W; Patel, Manesh R; Singer, Daniel E; Califf, Robert M (2011. )Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment.European heart journal, ,32 (19 ),2387-94

Povsic, Thomas J; Wargin, William A; Alexander, John H; Krasnow, Joshua; Krolick, Merill; Cohen, Mauricio G; Mehran, Roxana; Buller, Christopher E; Bode, Christoph; Zelenkofske, Steven L; Rusconi, Christopher P; Becker, Richard C (2011. )Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy.European heart journal, ,32 (19 ),2412-9

Faxon, David P; Eikelboom, John W; Berger, Peter B; Holmes, David R; Bhatt, Deepak L; Moliterno, David J; Becker, Richard C; Angiolillo, Dominick J (2011. )Consensus document: antithrombotic therapy in patients with atrial fibrillation undergoing coronary stenting. A North-American perspective.Thrombosis and haemostasis, ,106 (4 ),572-84

Ahmad, Tariq; Voora, Deepak; Becker, Richard C (2011. )The pharmacogenetics of antiplatelet agents: towards personalized therapy?.Nature reviews. Cardiology, ,8 (10 ),560-71

Lopes, Renato D; Becker, Richard C; Alexander, John H; Armstrong, Paul W; Califf, Robert M; Chan, Mark Y; Crowther, Mark; Granger, Christopher B; Harrington, Robert A; Hylek, Elaine M; James, Stefan K; Jolicoeur, E Marc; Mahaffey, Kenneth W; Newby, L Kristin; Peterson, Eric D; Pieper, Karen S; Van de Werf, Frans; Wallentin, Lars; White, Harvey D; Carvalho, Antonio C; Giraldez, Roberto R; Guimaraes, Helio P; Nader, Helena B; Kalil, Renato A K; Bizzachi, Joyce M A; Lopes, Antonio C; Garcia, David A (2011. )Highlights from the III International Symposium of Thrombosis and Anticoagulation (ISTA), October 14-16, 2010, São Paulo, Brazil.Journal of thrombosis and thrombolysis, ,32 (2 ),242-66

Woodruff, Rebecca S; Sullenger, Bruce; Becker, Richard C (2011. )The many faces of the contact pathway and their role in thrombosis.Journal of thrombosis and thrombolysis, ,32 (1 ),9-20

Becker, Richard C (2011. )Early-onset obesity and the unwanted promise of thrombosis.Journal of thrombosis and thrombolysis, ,32 (1 ),125-8

Held, Claes; Asenblad, Nils; Bassand, Jean Pierre; Becker, Richard C; Cannon, Christopher P; Claeys, Marc J; Harrington, Robert A; Horrow, Jay; Husted, Steen; James, Stefan K; Mahaffey, Kenneth W; Nicolau, José C; Scirica, Benjamin M; Storey, Robert F; Vintila, Marius; Ycas, Joseph; Wallentin, Lars (2011. )Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial.Journal of the American College of Cardiology, ,57 (6 ),672-84

Povsic, Thomas J; Cohen, Mauricio G; Mehran, Roxana; Buller, Christopher E; Bode, Christoph; Cornel, Jan H; Kasprzak, Jaros?aw D; Montalescot, Gilles; Joseph, Diane; Wargin, William A; Rusconi, Christopher P; Zelenkofske, Steven L; Becker, Richard C; Alexander, John H (2011. )A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial.American heart journal, ,161 (2 ),261-268.e1-2

Xu, Weixian; Wang, Tracy Y; Becker, Richard C (2011. )Hematologic diseases: from within the heart.Revista española de cardiología (English ed.), ,64 (7 ),606-13

Williams, Marlene S; Weiss, Ethan J; Sabatine, Marc S; Simon, Daniel I; Bahou, Wadie F; Becker, Lewis C; Parise, Leslie V; Dauerman, Harold L; French, Patricia A; Smyth, Susan S; Becker, Richard C (2010. )Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development.Arteriosclerosis, thrombosis, and vascular biology, ,30 (12 ),2372-84

Povsic, Thomas J; Sullenger, Bruce A; Zelenkofske, Steven L; Rusconi, Christopher P; Becker, Richard C (2010. )Translating nucleic acid aptamers to antithrombotic drugs in cardiovascular medicine.Journal of cardiovascular translational research, ,3 (6 ),704-16

Steg, Philippe Gabriel; James, Stefan; Harrington, Robert A; Ardissino, Diego; Becker, Richard C; Cannon, Christopher P; Emanuelsson, Håkan; Finkelstein, Ariel; Husted, Steen; Katus, Hugo; Kilhamn, Jan; Olofsson, Sylvia; Storey, Robert F; Weaver, W Douglas; Wallentin, Lars (2010. )Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis.Circulation, ,122 (21 ),2131-41

Wallentin, Lars; James, Stefan; Storey, Robert F; Armstrong, Martin; Barratt, Bryan J; Horrow, Jay; Husted, Steen; Katus, Hugo; Steg, P Gabriel; Shah, Svati H; Becker, Richard C (2010. )Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial.Lancet, ,376 (9749 ),1320-8

Cohen, Mauricio G; Purdy, Drew A; Rossi, Joseph S; Grinfeld, Liliana R; Myles, Shelley K; Aberle, Laura H; Greenbaum, Adam B; Fry, Edward; Chan, Mark Y; Tonkens, Ross M; Zelenkofske, Steven; Alexander, John H; Harrington, Robert A; Rusconi, Christopher P; Becker, Richard C (2010. )First clinical application of an actively reversible direct factor IXa inhibitor as an anticoagulation strategy in patients undergoing percutaneous coronary intervention.Circulation, ,122 (6 ),614-22

Woodruff, Becky; Sullenger, Bruce; Becker, Richard C (2010. )Antithrombotic therapy in acute coronary syndrome: how far up the coagulation cascade will we go?.Current cardiology reports, ,12 (4 ),315-20

Lopes, Renato D; Garcia, David; Becker, Richard C; Granger, Christopher B; Newby, L Kristin; Alexander, John H; Jolicoeur, E Marc; Handler, Allison; Pieper, Karen S; Carvalho, Antonio C; Guimaraes, Helio P; Chamone, Dalton A F; Baruzzi, Antonio C; Machado, Fabio S; Timerman, Ari; Lopes, Antonio C (2010. )Highlights from the II International Symposium of Thrombosis and Anticoagulation (ISTA), October 22-23, 2009, São Paulo, Brazil.Journal of thrombosis and thrombolysis, ,29 (4 ),395-408

Brummett, Beverly H; Boyle, Stephen H; Ortel, Thomas L; Becker, Richard C; Siegler, Ilene C; Williams, Redford B (2010. )Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall.Psychosomatic medicine, ,72 (4 ),333-9

Rao, Sunil V; Melloni, Chiara; Myles-Dimauro, Shelley; Broderick, Samuel; Kosinski, Andrzej S; Kleiman, Neal S; Dzavík, Vladimír; Tanguay, Jean Francois; Chandna, Harish; Gammon, Roger; Rivera, Ernesto; Alexander, John H; Fier, Ian; Roach, James; Becker, Richard C (2010. )Evaluation of a new heparin agent in percutaneous coronary intervention: results of the phase 2 evaluation of M118 IN pErcutaNeous Coronary intErvention (EMINENCE) Trial.Circulation, ,121 (15 ),1713-21

Krishnan, Anandi; Lopes, Renato D; Alexander, John H; Becker, Richard C; Goldstein, Larry B (2010. )Antithrombotic therapy for ischemic stroke: guidelines translated for the clinician.Journal of thrombosis and thrombolysis, ,29 (3 ),368-77

Chan, Mark Y; Becker, Richard C; Sim, Ling-Ling; Tan, Virlynn; Lee, Chi-Hang; Low, Adrian F H; Teo, Swee-Guan; Ng, Kheng-Siang; Tan, Huay-Cheem; Yeo, Tiong-Cheng (2010. )Reperfusion strategy and mortality in ST-elevation myocardial infarction among patients with and without impaired renal function. Annals of the Academy of Medicine, Singapore, ,39 (3 ),179-84

Mackman, Nigel; Becker, Richard C (2010. )DVT: a new era in anticoagulant therapy.Arteriosclerosis, thrombosis, and vascular biology, ,30 (3 ),369-71

Becker, Richard C; Gurbel, Paul A (2010. )Platelet P2Y12 receptor antagonist pharmacokinetics and pharmacodynamics: A foundation for distinguishing mechanisms of bleeding and anticipated risk for platelet-directed therapies.Thrombosis and haemostasis, ,103 (3 ),535-44

Katz, Jason N; Shah, Bimal R; Volz, Elizabeth M; Horton, John R; Shaw, Linda K; Newby, L Kristin; Granger, Christopher B; Mark, Daniel B; Califf, Robert M; Becker, Richard C (2010. )Evolution of the coronary care unit: clinical characteristics and temporal trends in healthcare delivery and outcomes.Critical care medicine, ,38 (2 ),375-81

Cannon, Christopher P; Harrington, Robert A; James, Stefan; Ardissino, Diego; Becker, Richard C; Emanuelsson, Håkan; Husted, Steen; Katus, Hugo; Keltai, Matyas; Khurmi, Nardev S; Kontny, Frederic; Lewis, Basil S; Steg, Philippe Gabriel; Storey, Robert F; Wojdyla, Daniel; Wallentin, Lars (2010. )Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study.Lancet, ,375 (9711 ),283-93

Kiefer, Todd L; Becker, Richard C (2009. )Inhibitors of platelet adhesion.Circulation, ,120 (24 ),2488-95

Becker, Richard C; Scheiman, James; Dauerman, Harold L; Spencer, Frederick; Rao, Sunil; Sabatine, Marc; Johnson, David A; Chan, Frances; Abraham, Neena S; Quigley, Eamonn M M (2009. )Management of platelet-directed pharmacotherapy in patients with atherosclerotic coronary artery disease undergoing elective endoscopic gastrointestinal procedures.The American journal of gastroenterology, ,104 (12 ),2903-17

Becker, Richard C; Chan, Mark Y (2009. )REG-1, a regimen comprising RB-006, a Factor IXa antagonist, and its oligonucleotide active control agent RB-007 for the potential treatment of arterial thrombosis. Current opinion in molecular therapeutics, ,11 (6 ),707-15

Smyth, S S; McEver, R P; Weyrich, A S; Morrell, C N; Hoffman, M R; Arepally, G M; French, P A; Dauerman, H L; Becker, R C (2009. )Platelet functions beyond hemostasis.Journal of thrombosis and haemostasis : JTH, ,7 (11 ),1759-66

Chan, Mark Y; Weitz, Jeffrey I; Merhi, Yahye; Harrington, Robert A; Becker, Richard C (2009. )Catheter thrombosis and percutaneous coronary intervention: fundamental perspectives on blood, artificial surfaces and antithrombotic drugs.Journal of thrombosis and thrombolysis, ,28 (3 ),366-80

Wallentin, Lars; Becker, Richard C; Budaj, Andrzej; Cannon, Christopher P; Emanuelsson, Håkan; Held, Claes; Horrow, Jay; Husted, Steen; James, Stefan; Katus, Hugo; Mahaffey, Kenneth W; Scirica, Benjamin M; Skene, Allan; Steg, Philippe Gabriel; Storey, Robert F; Harrington, Robert A ; Freij, Anneli; Thorsén, Mona (2009. )Ticagrelor versus clopidogrel in patients with acute coronary syndromes.The New England journal of medicine, ,361 (11 ),1045-57

Berger, Jeffrey S; Elliott, Laine; Gallup, Dianne; Roe, Matthew; Granger, Christopher B; Armstrong, Paul W; Simes, R John; White, Harvey D; Van de Werf, Frans; Topol, Eric J; Hochman, Judith S; Newby, L Kristin; Harrington, Robert A; Califf, Robert M; Becker, Richard C; Douglas, Pamela S (2009. )Sex differences in mortality following acute coronary syndromes.JAMA : the journal of the American Medical Association, ,302 (8 ),874-82

Smyth, Susan S; Woulfe, Donna S; Weitz, Jeffrey I; Gachet, Christian; Conley, Pamela B; Goodman, Shaun G; Roe, Matthew T; Kuliopulos, Athan; Moliterno, David J; French, Patricia A; Steinhubl, Steven R; Becker, Richard C (2009. )G-protein-coupled receptors as signaling targets for antiplatelet therapy.Arteriosclerosis, thrombosis, and vascular biology, ,29 (4 ),449-57

Berger, Jeffrey S; Frye, Carla B; Harshaw, Qing; Edwards, Fred H; Steinhubl, Steven R; Becker, Richard C (2008. )Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis.Journal of the American College of Cardiology, ,52 (21 ),1693-701

Becker, Richard C; Sane, David (2008. )Early career investigator's circle: identifying and nurturing the next generation of scientists and scientific writers.Journal of thrombosis and thrombolysis, ,26 (2 ),165

Lohrmann, Jens; Becker, Richard C (2008. )New anticoagulants--the path from discovery to clinical practice.The New England journal of medicine, ,358 (26 ),2827-9

Douketis, James D; Berger, Peter B; Dunn, Andrew S; Jaffer, Amir K; Spyropoulos, Alex C; Becker, Richard C; Ansell, Jack (2008. )The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).Chest, ,133 (6 Suppl ),299S-339S

Chan, Mark Y; Becker, Richard C; Harrington, Robert A; Peterson, Eric D; Armstrong, Paul W; White, Harvey; Fox, Keith A A; Ohman, E Magnus; Roe, Matthew T (2008. )Noninvasive, medical management for non-ST-elevation acute coronary syndromes.American heart journal, ,155 (3 ),397-407

Gurbel, Paul A; Becker, Richard C; Mann, Kenneth G; Steinhubl, Steven R; Michelson, Alan D (2007. )Platelet function monitoring in patients with coronary artery disease.Journal of the American College of Cardiology, ,50 (19 ),1822-34

Becker, Richard C (2007. )Off-target properties of pharmacotherapy and the importance of mechanistic investigations in early clinical phase drug development.Journal of thrombosis and thrombolysis, ,23 (2 ),159-61

Katz, Jason N; Turer, Aslan T; Becker, Richard C (2007. )Cardiology and the critical care crisis: a perspective.Journal of the American College of Cardiology, ,49 (12 ),1279-82

Dyke, Christopher K; Steinhubl, Steven R; Kleiman, Neal S; Cannon, Richard O; Aberle, Laura G; Lin, Min; Myles, Shelley K; Melloni, Chiara; Harrington, Robert A; Alexander, John H; Becker, Richard C; Rusconi, Christopher P (2006. )First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity.Circulation, ,114 (23 ),2490-7

Patel, Manesh R; Meine, Trip J; Lindblad, Lauren; Griffin, Jeffrey; Granger, Christopher B; Becker, Richard C; Van de Werf, Frans; White, Harvey; Califf, Robert M; Harrington, Robert A (2006. )Cardiac tamponade in the fibrinolytic era: analysis of >100,000 patients with ST-segment elevation myocardial infarction.American heart journal, ,151 (2 ),316-22

Krishnan, Ranjini; Becker, Richard J; Beighley, Lisa M; López-Candales, Angel (2005. )Impact of body mass index on markers of left ventricular thickness and mass calculation: results of a pilot analysis.Echocardiography (Mount Kisco, N.Y.), ,22 (3 ),203-10

Becker, Richard C; Alexander, John H; Li, Youfu; Robertson, Thomas; Kunitada, Satoshi; Spencer, Frederick A; Yang, Hongqiu; Harrington, Robert A (2004. )Vascular endothelial tissue factor pathway inhibitor kinetics in culture following exposure to DX-9065a--a selective and direct factor Xa inhibitor.Journal of thrombosis and thrombolysis, ,18 (3 ),193-7

Dyke, Christopher K; Becker, Richard C; Kleiman, Neal S; Hochman, Judith S; Bovill, Edwin G; Lincoff, A Michael; Gerstenblith, Gary; Dzavik, Vladimir; Gardner, Laura H; Hasselblad, Vic; Zillman, Linda A; Shimoto, Yoshimasa; Robertson, Thomas L; Kunitada, Satoshi; Armstrong, Paul W; Harrington, Robert A (2002. )First experience with direct factor Xa inhibition in patients with stable coronary disease: a pharmacokinetic and pharmacodynamic evaluation. Circulation, ,105 (20 ),2385-91

Harrold, Leslie R; Gurwitz, Jerry H; Tate, Janet P; Becker, Richard; Stuart, Tammy; Elwell, Anne; Radford, Martha (2002. )Physician attitudes concerning anticoagulation services in the long-term care setting. Journal of thrombosis and thrombolysis, ,14 (1 ),59-64

Becker, Richard C (2002. )Choice of agents to limit the coagulation cascade in acute coronary syndromes. Current cardiology reports, ,4 (4 ),272-7

Becker, Richard; Smith, Marion; Maier, Jerry (2002. )1Q[3a]. Are hospitals focusing enough on disaster readiness? .Hospitals & health networks / AHA, ,76 (7 ),30

Bonow, Robert O; Mitch, William E; Nesto, Richard W; O'Gara, Patrick T; Becker, Richard C; Clark, Luther T; Hunt, Sharon; Jialal, Ishwarlal; Lipshultz, Stephen E; Loh, Evan (2002. )Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group V: management of cardiovascular-renal complications. Circulation, ,105 (18 ),e159-64

Becker, Richard C; Spencer, Frederick A; Gibson, Michael; Rush, Janet E; Sanderink, Gerard; Murphy, Sabina A; Ball, Steven P; Antman, Elliott M (2002. )Influence of patient characteristics and renal function on factor Xa inhibition pharmacokinetics and pharmacodynamics after enoxaparin administration in non-ST-segment elevation acute coronary syndromes. American heart journal, ,143 (5 ),753-9

Li, You Fu; Spencer, Frederick A; Becker, Richard C (2002. )Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa receptor-directed platelet inhibition. American heart journal, ,143 (4 ),725-32

Ali, Omar A; Okike, Nsidinanya; Hogan, Robert G; Becker, Richard C (2002. )Intramural hematoma of the thoracic aorta in a woman with neurofibromatosis. The Annals of thoracic surgery, ,73 (3 ),958-60

Becker, Richard C.; Spencer, Frederick A. (2001. )Moving Up the Coagulation Cascade: Potential Factor X Inhibition for Percutaneous Coronary Intervention. Current interventional cardiology reports, ,3 (3 ),251-259

Boyle, Stephen H; Samad, Zainab; Becker, Richard C; Williams, Redford; Kuhn, Cynthia; Ortel, Thomas L; Kuchibhatla, Maragatha; Prybol, Kevin; Rogers, Joseph; O'Connor, Christopher; Velazquez, Eric J; Jiang, Wei Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease.Psychosomatic medicine, ,75 (9 ),822-31

Kim, Joonseok; Becker, Richard C (2016. )Aspirin dosing frequency in the primary and secondary prevention of cardiovascular events.Journal of thrombosis and thrombolysis, ,

Piccini, Jonathan P; Hellkamp, Anne S; Washam, Jeffrey B; Becker, Richard C; Breithardt, Günter; Berkowitz, Scott D; Halperin, Jonathan L; Hankey, Graeme J; Hacke, Werner; Mahaffey, Kenneth W; Nessel, Christopher C; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R (2015. )Polypharmacy and the Efficacy and Safety of Rivaroxaban versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation.Circulation, ,

Sherwood, Matthew W; Nessel, Christopher C; Hellkamp, Anne S; Mahaffey, Kenneth W; Piccini, Jonathan P; Suh, Eun-Young; Becker, Richard C; Singer, Daniel E; Halperin, Jonathan L; Hankey, Graeme J; Berkowitz, Scott D; Fox, Keith A A; Patel, Manesh R (2015. )Gastrointestinal Bleeding in Patients With Atrial Fibrillation Treated With Rivaroxaban or Warfarin: ROCKET AF Trial.Journal of the American College of Cardiology, ,66 (21 ),2271-81

Ducrocq, Gregory; Schulte, Phillip J; Becker, Richard C; Cannon, Christopher P; Harrington, Robert A; Held, Claes; Himmelmann, Anders; Lassila, Riitta; Storey, Robert F; Sorbets, Emmanuel; Wallentin, Lars; Steg, Philippe Gabriel (2015. )Association of spontaneous and procedure-related bleeds with short- and long-term mortality after acute coronary syndromes: an analysis from the PLATO trial.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, ,11 (8 ),737-45

Lincoff, A Michael; Mehran, Roxana; Povsic, Thomas J; Zelenkofske, Steven L; Huang, Zhen; Armstrong, Paul W; Steg, P Gabriel; Bode, Christoph; Cohen, Mauricio G; Buller, Christopher; Laanmets, Peep; Valgimigli, Marco; Marandi, Toomas; Fridrich, Viliam; Cantor, Warren J; Merkely, Bela; Lopez-Sendon, Jose; Cornel, Jan H; Kasprzak, Jaroslaw D; Aschermann, Michael; Guetta, Victor; Morais, Joao; Sinnaeve, Peter R; Huber, Kurt; Stables, Rod; Sellers, Mary Ann; Borgman, Marilyn; Glenn, Lauren; Levinson, Arnold I; Lopes, Renato D; Hasselblad, Vic; Becker, Richard C; Alexander, John H (2015. )Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial.Lancet (London, England), ,

Ganjehei, Leila; Becker, Richard C (2015. )Aspirin dosing in cardiovascular disease prevention and management: an update.Journal of thrombosis and thrombolysis, ,40 (4 ),499-511

Becker, Richard C (2015. )The biochemistry, enzymology and pharmacology of non-vitamin K anticoagulant drug reversal agents and antidotes.Journal of thrombosis and thrombolysis, ,

Bansilal, Sameer; Bloomgarden, Zachary; Halperin, Jonathan L; Hellkamp, Anne S; Lokhnygina, Yuliya; Patel, Manesh R; Becker, Richard C; Breithardt, Günter; Hacke, Werner; Hankey, Graeme J; Nessel, Christopher C; Singer, Daniel E; Berkowitz, Scott D; Piccini, Jonathan P; Mahaffey, Kenneth W; Fox, Keith A A (2015. )Efficacy and safety of rivaroxaban in patients with diabetes and nonvalvular atrial fibrillation: the Rivaroxaban Once-daily, Oral, Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF Trial).American heart journal, ,170 (4 ),675-682.e8

Becker, Richard A; Patlewicz, Grace; Simon, Ted W; Rowlands, J Craig; Budinsky, Robert A (2015. )The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor.Regulatory toxicology and pharmacology : RTP, ,73 (1 ),172-90

Hagström, Emil; James, Stefan K; Bertilsson, Maria; Becker, Richard C; Himmelmann, Anders; Husted, Steen; Katus, Hugo A; Steg, Philippe Gabriel; Storey, Robert F; Siegbahn, Agneta; Wallentin, Lars (2015. )Growth differentiation factor-15 level predicts major bleeding and cardiovascular events in patients with acute coronary syndromes: results from the PLATO study.European heart journal, ,

Becker, Richard C (2015. )Measurement tools and antidotes for non-vitamin K oral anticoagulants.Journal of thrombosis and thrombolysis, ,

Douketis, James D; Spyropoulos, Alex C; Kaatz, Scott; Becker, Richard C; Caprini, Joseph A; Dunn, Andrew S; Garcia, David A; Jacobson, Alan; Jaffer, Amir K; Kong, David F; Schulman, Sam; Turpie, Alexander G G; Hasselblad, Vic; Ortel, Thomas L (2015. )Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation.The New England journal of medicine, ,373 (9 ),823-33

Varenhorst, Christoph; Eriksson, Niclas; Johansson, Åsa; Barratt, Bryan J; Hagström, Emil; Åkerblom, Axel; Syvänen, Ann-Christine; Becker, Richard C; James, Stefan K; Katus, Hugo A; Husted, Steen; Steg, Ph Gabriel; Siegbahn, Agneta; Voora, Deepak; Teng, Renli; Storey, Robert F; Wallentin, Lars (2015. )Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.European heart journal, ,36 (29 ),1901-12

Plunkett, Laura M; Kaplan, A Michael; Becker, Richard A (2015. )Challenges in using the ToxRefDB as a resource for toxicity prediction modeling.Regulatory toxicology and pharmacology : RTP, ,72 (3 ),610-4

Borgert, Christopher J; Wise, Kimberly; Becker, Richard A (2015. )Modernizing problem formulation for risk assessment necessitates articulation of mode of action.Regulatory toxicology and pharmacology : RTP, ,72 (3 ),538-51

Becker, Richard A; Ankley, Gerald T; Edwards, Stephen W; Kennedy, Sean W; Linkov, Igor; Meek, Bette; Sachana, Magdalini; Segner, Helmut; Van Der Burg, Bart; Villeneuve, Daniel L; Watanabe, Haruna; Barton-Maclaren, Tara S (2015. )Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.Regulatory toxicology and pharmacology : RTP, ,72 (3 ),514-37

Becker, Richard C; Helmy, Tarek (2015. )Are at least 12 months of dual antiplatelet therapy needed for all patients with drug-eluting stents? Not all patients with drug-eluting stents need at least 12 months of dual antiplatelet therapy.Circulation, ,131 (22 ),2010-9; discussion 2

Kang, Hyun-Jae; Clare, Robert M; Gao, Runlin; Held, Claes; Himmelmann, Anders; James, Stefan K; Lim, Soo Teik; Santoso, Anwar; Yu, Cheuk-Man; Wallentin, Lars; Becker, Richard C (2015. )Ticagrelor versus clopidogrel in Asian patients with acute coronary syndrome: A retrospective analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial.American heart journal, ,169 (6 ),899-905.e1

Velders, Matthijs A; Wallentin, Lars; Becker, Richard C; van Boven, Adrianus J; Himmelmann, Anders; Husted, Steen; Katus, Hugo A; Lindholm, Daniel; Morais, Joao; Siegbahn, Agneta; Storey, Robert F; Wernroth, Lisa; James, Stefan K (2015. )Biomarkers for risk stratification of patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention: Insights from the Platelet Inhibition and Patient Outcomes trial.American heart journal, ,169 (6 ),879-889.e7

Johansson, Åsa; Eriksson, Niclas; Becker, Richard C; Storey, Robert F; Himmelmann, Anders; Hagström, Emil; Varenhorst, Christoph; Axelsson, Tomas; Barratt, Bryan J; James, Stefan K; Katus, Hugo A; Steg, Philippe Gabriel; Syvänen, Ann-Christine; Wallentin, Lars; Siegbahn, Agneta (2015. )NLRC4 Inflammasome Is an Important Regulator of Interleukin-18 Levels in Patients With Acute Coronary Syndromes: Genome-Wide Association Study in the PLATelet inhibition and patient Outcomes Trial (PLATO).Circulation. Cardiovascular genetics, ,8 (3 ),498-506

Jiang, Wei; Boyle, Stephen H; Ortel, Thomas L; Samad, Zainab; Velazquez, Eric J; Harrison, Robert W; Wilson, Jennifer; Kuhn, Cynthia; Williams, Redford B; O'Connor, Christopher M; Becker, Richard C (2015. )Platelet aggregation and mental stress induced myocardial ischemia: Results from the Responses of Myocardial Ischemia to Escitalopram Treatment (REMIT) study.American heart journal, ,169 (4 ),496-507.e1

Patlewicz, Grace; Simon, Ted W; Rowlands, J Craig; Budinsky, Robert A; Becker, Richard A (2015. )Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes.Regulatory toxicology and pharmacology : RTP, ,71 (3 ),463-77

Becker, Richard A; Friedman, Katie Paul; Simon, Ted W; Marty, M Sue; Patlewicz, Grace; Rowlands, J Craig (2015. )An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity--proof of concept.Regulatory toxicology and pharmacology : RTP, ,71 (3 ),398-408

Singer, Daniel E; Hellkamp, Anne S; Yuan, Zhong; Lokhnygina, Yuliya; Patel, Manesh R; Piccini, Jonathan P; Hankey, Graeme J; Breithardt, Günter; Halperin, Jonathan L; Becker, Richard C; Hacke, Werner; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M (2015. )Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial.Journal of the American Heart Association, ,4 (3 ),e001349

Krishnamoorthy, Arun; Sherwood, Matthew W; Lopes, Renato D; Becker, Richard C (2015. )The periprocedural management of novel oral anticoagulants in patients with nonvalvular atrial fibrillation: rationale and a summary of the available evidence from phase 3 clinical trials.American heart journal, ,169 (3 ),315-22

Steinberg, Benjamin A; Hellkamp, Anne S; Lokhnygina, Yuliya; Patel, Manesh R; Breithardt, Günter; Hankey, Graeme J; Becker, Richard C; Singer, Daniel E; Halperin, Jonathan L; Hacke, Werner; Nessel, Christopher C; Berkowitz, Scott D; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M; Piccini, Jonathan P (2015. )Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial.European heart journal, ,36 (5 ),288-96

Webster, Christopher R; Mahaffy, Paul R; Atreya, Sushil K; Flesch, Gregory J; Mischna, Michael A; Meslin, Pierre-Yves; Farley, Kenneth A; Conrad, Pamela G; Christensen, Lance E; Pavlov, Alexander A; Martín-Torres, Javier; Zorzano, María-Paz; McConnochie, Timothy H; Owen, Tobias; Eigenbrode, Jennifer L; Glavin, Daniel P; Steele, Andrew; Malespin, Charles A; Archer, P Douglas; Sutter, Brad; Coll, Patrice; Freissinet, Caroline; McKay, Christopher P; Moores, John E; Schwenzer, Susanne P; Bridges, John C; Navarro-Gonzalez, Rafael; Gellert, Ralf; Lemmon, Mark T (2015. )Mars atmosphere. Mars methane detection and variability at Gale crater.Science (New York, N.Y.), ,347 (6220 ),415-7

Mahaffy, P R; Webster, C R; Stern, J C; Brunner, A E; Atreya, S K; Conrad, P G; Domagal-Goldman, S; Eigenbrode, J L; Flesch, G J; Christensen, L E; Franz, H B; Freissinet, C; Glavin, D P; Grotzinger, J P; Jones, J H; Leshin, L A; Malespin, C; McAdam, A C; Ming, D W; Navarro-Gonzalez, R; Niles, P B; Owen, T; Pavlov, A A; Steele, A; Trainer, M G; Williford, K H; Wray, J J (2015. )Mars atmosphere. The imprint of atmospheric evolution in the D/H of Hesperian clay minerals on Mars.Science (New York, N.Y.), ,347 (6220 ),412-4

Breithardt, Günter; Baumgartner, Helmut; Berkowitz, Scott D; Hellkamp, Anne S; Piccini, Jonathan P; Stevens, Susanna R; Lokhnygina, Yuliya; Patel, Manesh R; Halperin, Jonathan L; Singer, Daniel E; Hankey, Graeme J; Hacke, Werner; Becker, Richard C; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M (2014. )Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial.European heart journal, ,35 (47 ),3377-85

Wisler, James W; Becker, Richard C (2014. )Antithrombotic therapy: new areas to understand efficacy and bleeding.Expert opinion on therapeutic targets, ,18 (12 ),1427-34

Samad, Zainab; Boyle, Stephen; Ersboll, Mads; Vora, Amit N; Zhang, Ye; Becker, Richard C; Williams, Redford; Kuhn, Cynthia; Ortel, Thomas L; Rogers, Joseph G; O'Connor, Christopher M; Velazquez, Eric J; Jiang, Wei (2014. )Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease: insights from the REMIT study.Journal of the American College of Cardiology, ,64 (16 ),1669-78

Schlaudecker, Jeffrey; Becker, Richard (2014. )Inflammatory response and thrombosis in older individuals.Seminars in thrombosis and hemostasis, ,40 (6 ),669-74

Patlewicz, Grace; Ball, Nicholas; Becker, Richard A; Booth, Ewan D; Cronin, Mark T D; Kroese, Dinant; Steup, David; van Ravenzwaay, Ben; Hartung, Thomas (2014. )Read-across approaches--misconceptions, promises and challenges ahead. ALTEX, ,31 (4 ),387-96

Wong, Michael H; Atreya, Sushil K; Mahaffy, Paul N; Franz, Heather B; Malespin, Charles; Trainer, Melissa G; Stern, Jennifer C; Conrad, Pamela G; Manning, Heidi L K; Pepin, Robert O; Becker, Richard H; McKay, Christopher P; Owen, Tobias C; Navarro-González, Rafael; Jones, John H; Jakosky, Bruce M; Steele, Andrew (2013. )Isotopes of nitrogen on Mars: Atmospheric measurements by?Curiosity's mass spectrometer.Geophysical research letters, ,40 (23 ),6033-6037

Washam, Jeffrey B; Hellkamp, Anne S; Lokhnygina, Yuliya; Piccini, Jonathan P; Berkowitz, Scott D; Nessel, Christopher C; Becker, Richard C; Breithardt, Günter; Fox, Keith A A; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Singer, Daniel E; Patel, Manesh R (2017. )Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial).The American journal of cardiology, ,120 (4 ),588-594

Jiang, Rong; Babyak, Michael A; Brummett, Beverly H; Hauser, Elizabeth R; Shah, Svati H; Becker, Richard C; Siegler, Ilene C; Singh, Abanish; Haynes, Carol; Chryst-Ladd, Megan; Craig, Damian M; Williams, Redford B (2017. )Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort.American heart journal, ,190 ,40-45

Lowenstern, Angela; Storey, Robert F; Neely, Megan; Sun, Jie-Lena; Angiolillo, Dominick J; Cannon, Christopher P; Himmelmann, Anders; Huber, Kurt; James, Stefan K; Katus, Hugo A; Morais, Joao; Siegbahn, Agneta; Steg, Phillippe Gabriel; Wallentin, Lars; Becker, Richard C (2017. )Platelet-related biomarkers and their response to inhibition with aspirin and p2y12-receptor antagonists in patients with acute coronary syndrome.Journal of thrombosis and thrombolysis, ,44 (2 ),145-153

Sun, Yihong; Hu, Dayi; Stevens, Susanna; Lokhnygina, Yuliya; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Piccini, Jonathan P; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R (2017. )Efficacy and safety of rivaroxaban versus warfarin in patients from mainland China with nonvalvular atrial fibrillation: A subgroup analysis from the ROCKET AF trial.Thrombosis research, ,156 ,184-190

Balla, Somasekhara R; Cyr, Derek D; Lokhnygina, Yuliya; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Fox, Keith A A; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Piccini, Jonathan P; Singer, Daniel E; Patel, Manesh R (2017. )Relation of Risk of Stroke in Patients With Atrial Fibrillation to Body Mass Index (from Patients Treated With Rivaroxaban and Warfarin in the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation Trial).The American journal of cardiology, ,119 (12 ),1989-1996

Leef, George C; Hellkamp, Anne S; Patel, Manesh R; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Halperin, Jonathan L; Hankey, Graeme J; Hacke, Werner; Nessel, Christopher C; Singer, Daniel E; Fox, Keith A A; Mahaffey, Kenneth W; Piccini, Jonathan P (2017. )Safety and Efficacy of Rivaroxaban in Patients With Cardiac Implantable Electronic Devices: Observations From the ROCKET AF Trial.Journal of the American Heart Association, ,6 (6 ),

Pollack, Charles V; Davoudi, Farideh; Diercks, Deborah B; Becker, Richard C; James, Stefan K; Lim, Soo Teik; Schulte, Phillip J; Spinar, Jindrich; Steg, Philippe Gabriel; Storey, Robert F; Himmelmann, Anders; Wallentin, Lars; Cannon, Christopher P (2017. )Relative efficacy and safety of ticagelor vs clopidogrel as a function of time to invasive management in non-ST-segment elevation acute coronary syndrome in the PLATO trial.Clinical cardiology, ,40 (6 ),390-398

Johnson, David A; Lieberman, David; Inadomi, John M; Ladabaum, Uri; Becker, Richard C; Gross, Seth A; Hood, Kristin L; Kushins, Susan; Pochapin, Mark; Robertson, Douglas J (2017. )Increased Post-procedural Non-gastrointestinal Adverse Events After Outpatient Colonoscopy in High-risk Patients.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, ,15 (6 ),883-891.e9

Lindholm, Daniel; Hagström, Emil; James, Stefan K; Becker, Richard C; Cannon, Christopher P; Himmelmann, Anders; Katus, Hugo A; Maurer, Gerald; López-Sendón, José Luis; Steg, Philippe Gabriel; Storey, Robert F; Siegbahn, Agneta; Wallentin, Lars (2017. )Growth Differentiation Factor 15 at 1 Month After an Acute Coronary Syndrome Is Associated With Increased Risk of Major Bleeding.Journal of the American Heart Association, ,6 (4 ),

Ducrocq, Gregory; Schulte, Phillip J; Budaj, Andrzej; Cornel, Jan H; Held, Claes; Himmelmann, Anders; Husted, Steen; Storey, Robert F; Cannon, Christopher P; Becker, Richard C; James, Stefan K; Katus, Hugo A; Lopes, Renato D; Sorbets, Emmanuel; Wallentin, Lars; Steg, Philippe Gabriel (2017. )Balancing the risk of spontaneous ischemic and major bleeding events in acute coronary syndromes.American heart journal, ,186 ,91-99

Staudacher, Dawid L; Putz, Vera; Heger, Lukas; Reinöhl, Jochen; Hortmann, Marcus; Zelenkofske, Steven L; Becker, Richard C; Rusconi, Christopher P; Bode, Christoph; Ahrens, Ingo (2017. )Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes.European heart journal. Acute cardiovascular care, ,2048872617703065

Sun, Julia L; Boyle, Stephen H; Samad, Zainab; Babyak, Michael A; Wilson, Jennifer L; Kuhn, Cynthia; Becker, Richard C; Ortel, Thomas L; Williams, Redford B; Rogers, Joseph G; O'Connor, Christopher M; Velazquez, Eric J; Jiang, Wei (2017. )Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients.European journal of preventive cardiology, ,24 (6 ),591-599

Lindner, Samuel M; Fordyce, Christopher B; Hellkamp, Anne S; Lokhnygina, Yuliya; Piccini, Jonathan P; Breithardt, Günter; Mahaffey, Kenneth W; Singer, Daniel E; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Berkowitz, Scott D; Nessel, Christopher C; Becker, Richard C; Fox, Keith A A; Patel, Manesh R (2017. )Treatment Consistency Across Levels of Baseline Renal Function With Rivaroxaban or Warfarin: A ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) Analysis.Circulation, ,135 (10 ),1001-1003

Lindholm, Daniel; James, Stefan K; Bertilsson, Maria; Becker, Richard C; Cannon, Christopher P; Giannitsis, Evangelos; Harrington, Robert A; Himmelmann, Anders; Kontny, Frederic; Siegbahn, Agneta; Steg, Philippe Gabriel; Storey, Robert F; Velders, Matthijs A; Weaver, W Douglas; Wallentin, Lars (2017. )Biomarkers and Coronary Lesions Predict Outcomes after Revascularization in Non-ST-Elevation Acute Coronary Syndrome.Clinical chemistry, ,63 (2 ),573-584

Feigal, Jacob P; Boyle, Stephen H; Samad, Zainab; Velazquez, Eric J; Wilson, Jennifer L; Becker, Richard C; Williams, Redford B; Kuhn, Cynthia M; Ortel, Thomas L; Rogers, Joseph G; O'Connor, Christopher M; Jiang, Wei (2017. )Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia.Journal of psychosomatic research, ,93 ,14-18

Nimjee, Shahid M; White, Rebekah R; Becker, Richard C; Sullenger, Bruce A (2017. )Aptamers as Therapeutics.Annual review of pharmacology and toxicology, ,57 ,61-79

Povsic, Thomas J; Lawrence, Monica G; Lincoff, A Michael; Mehran, Roxana; Rusconi, Christopher P; Zelenkofske, Steven L; Huang, Zhen; Sailstad, Jeffrey; Armstrong, Paul W; Steg, P Gabriel; Bode, Christoph; Becker, Richard C; Alexander, John H; Adkinson, N Franklin; Levinson, Arnold I (2016. )Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer.The Journal of allergy and clinical immunology, ,138 (6 ),1712-1715

Björquist, Anna; Di Buduo, Christian A; Femia, Eti A; Storey, Robert F; Becker, Richard C; Balduini, Alessandra; Nylander, Sven; Cattaneo, Marco (2016. )Studies of the interaction of ticagrelor with the P2Y13 receptor and with P2Y13-dependent pro-platelet formation by human megakaryocytes.Thrombosis and haemostasis, ,116 (6 ),1079-1088

Kayse, Regina; Becker, Richard C (2016. )The case for preoperative aspirin administration in patients undergoing elective CABG: is it open or closed?.Annals of translational medicine, ,4 (Suppl 1 ),S26

Shah, Rohan; Hellkamp, Anne; Lokhnygina, Yuliya; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Fox, Keith A A; Nessel, Christopher C; Mahaffey, Kenneth W; Piccini, Jonathan P; Singer, Daniel E; Patel, Manesh R (2016. )Use of concomitant aspirin in patients with atrial fibrillation: Findings from the ROCKET AF trial.American heart journal, ,179 ,77-86

Sherwood, Matthew W; Cyr, Derek D; Jones, W Schuyler; Becker, Richard C; Berkowitz, Scott D; Washam, Jeffrey B; Breithardt, Günter; Fox, Keith A A; Halperin, Jonathan L; Hankey, Graeme J; Singer, Daniel E; Piccini, Jonathan P; Nessel, Christopher C; Mahaffey, Kenneth W; Patel, Manesh R (2016. )Use of Dual Antiplatelet Therapy and Patient Outcomes in Those Undergoing Percutaneous Coronary Intervention: The ROCKET AF Trial.JACC. Cardiovascular interventions, ,9 (16 ),1694-702

Vemulapalli, Sreekanth; Hellkamp, Anne S; Jones, W Schuyler; Piccini, Jonathan P; Mahaffey, Kenneth W; Becker, Richard C; Hankey, Graeme J; Berkowitz, Scott D; Nessel, Christopher C; Breithardt, Günter; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R (2016. )Blood pressure control and stroke or bleeding risk in anticoagulated patients with atrial fibrillation: Results from the ROCKET AF Trial.American heart journal, ,178 ,74-84

DeVore, Adam D; Hellkamp, Anne S; Becker, Richard C; Berkowitz, Scott D; Breithardt, Guenter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R; Piccini, Jonathan P (2016. )Hospitalizations in patients with atrial fibrillation: an analysis from ROCKET AF.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, ,18 (8 ),1135-42

Piccini, Jonathan P; Hellkamp, Anne S; Washam, Jeffrey B; Becker, Richard C; Breithardt, Günter; Berkowitz, Scott D; Halperin, Jonathan L; Hankey, Graeme J; Hacke, Werner; Mahaffey, Kenneth W; Nessel, Christopher C; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R (2016. )Response by Piccini et al to Letters Regarding Article, "Polypharmacy and the Efficacy and Safety of Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Nonvalvular Atrial Fibrillation".Circulation, ,134 (2 ),e7-8

Fordyce, Christopher B; Hellkamp, Anne S; Lokhnygina, Yuliya; Lindner, Samuel M; Piccini, Jonathan P; Becker, Richard C; Berkowitz, Scott D; Breithardt, Günter; Fox, Keith A A; Mahaffey, Kenneth W; Nessel, Christopher C; Singer, Daniel E; Patel, Manesh R (2016. )On-Treatment Outcomes in Patients With Worsening Renal Function With Rivaroxaban Compared With Warfarin: Insights From ROCKET AF.Circulation, ,134 (1 ),37-47

Shimada, Yuichi J; Bansilal, Sameer; Wiviott, Stephen D; Becker, Richard C; Harrington, Robert A; Himmelmann, Anders; Neely, Benjamin; Husted, Steen; James, Stefan K; Katus, Hugo A; Lopes, Renato D; Steg, Ph Gabriel; Storey, Robert F; Wallentin, Lars; Cannon, Christopher P (2016. )Impact of glycoprotein IIb/IIIa inhibitors on the efficacy and safety of ticagrelor compared with clopidogrel in patients with acute coronary syndromes: Analysis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial.American heart journal, ,177 ,1-8

Breithardt, Günter; Baumgartner, Helmut; Berkowitz, Scott D; Hellkamp, Anne S; Piccini, Jonathan P; Lokhnygina, Yuliya; Halperin, Jonathan L; Singer, Daniel E; Hankey, Graeme J; Hacke, Werner; Becker, Richard C; Nessel, Christopher C; Mahaffey, Kenneth W; Califf, Robert M; Fox, Keith A A; Patel, Manesh R (2016. )Native valve disease in patients with non-valvular atrial fibrillation on warfarin or rivaroxaban.Heart (British Cardiac Society), ,102 (13 ),1036-43

Nimjee, Shahid M; Povsic, Thomas J; Sullenger, Bruce A; Becker, Richard C (2016. )Translation and Clinical Development of Antithrombotic Aptamers.Nucleic acid therapeutics, ,26 (3 ),147-55

Ruff, Christian T; Ansell, Jack E; Becker, Richard C; Benjamin, Emelia J; Deicicchi, David J; Mark Estes, N A; Ezekowitz, Michael D; Fanikos, John; Fareed, Jawed; Garcia, David; Giugliano, Robert P; Goldhaber, Samuel Z; Granger, Christopher; Healey, Jeff S; Hull, Russell; Hylek, Elaine M; Libby, Peter; Lopes, Renato D; Mahaffey, Kenneth W; Mega, Jessica; Piazza, Gregory; Sasahara, Arthur A; Sorond, Farzaneh A; Spyropoulos, Alex C; Walenga, Jeanine M; Weitz, Jeffrey I (2016. )North American Thrombosis Forum, AF Action Initiative Consensus Document.The American journal of medicine, ,129 (5 Suppl ),S1-S29

Abo-Salem, Elsayed; Becker, Richard C (2016. )Reversal of novel oral anticoagulants.Current opinion in pharmacology, ,27 ,86-91

Johansson, Åsa; Eriksson, Niclas; Lindholm, Daniel; Varenhorst, Christoph; James, Stefan; Syvänen, Ann-Christine; Axelsson, Tomas; Siegbahn, Agneta; Barratt, Bryan J; Becker, Richard C; Himmelmann, Anders; Katus, Hugo A; Steg, Philippe Gabriel; Storey, Robert F; Wallentin, Lars (2016. )Genome-wide association and Mendelian randomization study of NT-proBNP in patients with acute coronary syndrome.Human molecular genetics, ,25 (7 ),1447-56

Muntner, Paul; Becker, Richard C; Calhoun, David; Chen, Daian; Cowley, Allen W; Flynn, Joseph T; Grobe, Justin L; Kidambi, Srividya; Kotchen, Theodore A; Lackland, Daniel T; Leslie, Kimberly K; Li, Yingchuan; Liang, Mingyu; Lloyd, Augusta; Mattson, David L; Mendizabal, Brenda; Mitsnefes, Mark; Nair, Anand; Pierce, Gary L; Pollock, Jennifer S; Safford, Monika M; Santillan, Mark K; Sigmund, Curt D; Thomas, Stephen J; Urbina, Elaine M (2016. )Introduction to the American Heart Association's Hypertension Strategically Focused Research Network.Hypertension (Dallas, Tex. : 1979), ,67 (4 ),674-80

Pokorney, Sean D; Piccini, Jonathan P; Stevens, Susanna R; Patel, Manesh R; Pieper, Karen S; Halperin, Jonathan L; Breithardt, Günter; Singer, Daniel E; Hankey, Graeme J; Hacke, Werner; Becker, Richard C; Berkowitz, Scott D; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M (2016. )Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF.Journal of the American Heart Association, ,5 (3 ),e002197

Post Graduate Training and Education

Internal Medicine: , Medicine Chief Resident, Cleveland Clinic Foundation, ,

Cardiovascular Fellowship: , Chief Fellow, University of Massachusetts, ,Worcester, MA

Hematology Fellowship: , Coagulation, Thrombosis and Vascular Biology, Cleveland Clinic Foundation, ,

Contact Information

Academic - University of Cincinnati College of Medicine
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 513.558.1067
Fax: 513.558.2884
richard.becker@uc.edu