Justin Benoit

Justin L. Benoit , MD

Associate Professor of Clinical

University of Cincinnati College of Medicine
Department of Emergency Medicine
Eden Ave & Albert Sabin Way, Holmes Hospital
Cincinnati , Ohio 45267-0769
Phone 513-558-5281
Fax 513-558-5791
Email Justin.Benoit@uc.edu

Education

Bachelor's Degree: University of Maryland, College Park (Cell and Molecular Biology and Genetics)

Master's Degree: University of Cincinnati (Clinical and Translational Research)

Medical Degree: Case Western Reserve University

Residency: University of Cincinnati (Emergency Medicine)

Fellowship: University of Cincinnati (Emergency Medical Services; Clinical Research)

Certifications

American Board of Emergency Medicine (Emergency Medical Services) (Certification Date: 11-17-2017 )

American Board of Emergency Medicine (Certification Date: 11-19-2015 )

Clinical Interests

Emergency Medicine

Specialities

Emergency Medicine

Research and Practice Interests

Prehospital Medicine
Cardiac Arrest
Emergency Airway Management
Biomarkers

Research Support

Grant: #RF2015-001 Investigators:Benoit, Justin 07-01-2015 -06-30-2017 Society for Academic Emergency Medicine Timing of Airway Interventions and Survival after Out of Hospital Cardiac Arrest Role:PI $100,000.00 Active Level:Private Non-Profit

Grant: #N005339714 / U01 HL133818 Investigators:Benoit, Justin 06-01-2017 -05-31-2018 National Heart, Lung and Blood Institute ACCESS to the cardiac catheterization laboratory in patients without ST-segment elevation myocardial infarction resuscitated from out-of-hospital ventricular fibrillation cardiac arrest Role:PI $27,800.00 Awarded Level:Federal

Grant: #00012343 \ HL145269 Investigators:Benoit, Justin; Knight, William 09-19-2019 -08-31-2021 National Heart, Lung and Blood Institute 1/2 ICECAP: Influence of Cooling duration on Efficacy in Cardiac Arrest Patients Role:PI $179,932.38 Active Level:Federal

Grant: #N008587901_INV-017069 Investigators:Benoit, Justin 04-15-2020 -10-15-2020 Bill & Melinda Gates Foundation Angiotensin receptor blockers for novel SARS-CoV-2 Role:PI $46,000.00 Active Level:Private Non-Profit

Grant: #SUBK00017795/62556501-179030/R01NS119825 Investigators:Benoit, Justin 12-01-2021 -11-30-2025 National Institute of Neurological Disorders and Stroke PREcision Care In Cardiac ArrEst - ICECAP (PRECICECAP) Role:PI 20000.00 Hold Level:Federal

Publications

Peer Reviewed Publications

Benoit, Justin L; McMullan, Jason T; Wang, Henry E; Xie, Changchun; Xu, Peixin; Hart, Kimberly W; Stolz, Uwe; Lindsell, Christopher J Timing of Advanced Airway Placement after Witnessed Out-of-Hospital Cardiac Arrest.Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, , 23 (6 ) ,838-846 More Information

Monette, Derek L; Brown, Calvin A; Benoit, Justin L; McMullan, Jason T; Carleton, Steven C; Steuerwald, Michael T; Eyre, Andrew; Pallin, Daniel J (2019. ) The Impact of Video Laryngoscopy on the Clinical Learning Environment of Emergency Medicine Residents: A Report of 14,313 Intubations.AEM education and training, , 3 (2 ) ,156-162 More Information

Benoit, Justin L; Khatri, Pooja; Adeoye, Opeolu M; Broderick, Joseph P; McMullan, Jason T; Scheitz, Jan F; Vagal, Achala S; Eckman, Mark H Prehospital Triage of Acute Ischemic Stroke Patients to an Intravenous tPA-Ready versus Endovascular-Ready Hospital: A Decision Analysis.Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, , 22 (6 ) ,722-733 More Information

Benoit, Justin L; Vogele, Jennifer; Hart, Kimberly W; Lindsell, Christopher J; McMullan, Jason T (2017. ) Passive ultra-brief video training improves performance of compression-only cardiopulmonary resuscitation.Resuscitation, , 115 ,116-119 More Information

Benoit, Justin L; Hart, Kimberly W; Soliman, Adam A; Barczak, Christopher M; Sibilia, Robert S; Lindsell, Christopher J; Fermann, Gregory J (2017. ) Developing a standardized measurement of alcohol intoxication.The American journal of emergency medicine, , 35 (5 ) ,725-730 More Information

Benoit, Justin L; Widmeier, Keith C; McMullan, Jason T (2017. ) Evaluating Research: Seven essential questions to evaluate clinical research. JEMS : a journal of emergency medical services, , 42 (2 ) ,50-3

Benoit, Justin L; Prince, David K; Wang, Henry E (2015. ) Mechanisms linking advanced airway management and cardiac arrest outcomes.Resuscitation, , 93 ,124-7 More Information

Benoit, Justin L; Gerecht, Ryan B; Steuerwald, Michael T; McMullan, Jason T (2015. ) Endotracheal intubation versus supraglottic airway placement in out-of-hospital cardiac arrest: A meta-analysis.Resuscitation, , 93 ,20-6 More Information

McMullan, Jason; Benoit, Justin (2014. ) Airway choices matter. The effect of prehospital airway management on cardiac arrest outcomes. JEMS : a journal of emergency medical services, , Suppl ,4-7

Hicks, Caitlin W; Engineer, Rakesh S; Benoit, Justin L; Dasarathy, Srinivasan; Christenson, Robert H; Peacock, William F (2014. ) Procalcitonin as a biomarker for early sepsis in the emergency department.European journal of emergency medicine : official journal of the European Society for Emergency Medicine, , 21 (2 ) ,112-7 More Information

Benoit, Justin L; Hicks, Caitlin W; Engineer, Rakesh S; Hart, Kimberly W; Lindsell, Christopher J; Peacock, William F (2013. ) ST2 in emergency department patients with noncardiac dyspnea.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, , 20 (11 ) ,1207-10 More Information

Engineer, Rakesh S; Benoit, Justin L; Hicks, Caitlin W; Kolattukudy, Sunny J; Burkhoff, Daniel; Peacock, W Frank (2012. ) Hemodynamic changes as a diagnostic tool in acute heart failure--a pilot study.The American journal of emergency medicine, , 30 (1 ) ,174-80 More Information

Henry, Brandon Michael; Benoit, Stefanie W; de Oliveira, Maria Helena Santos; Hsieh, Wan Chin; Benoit, Justin; Ballout, Rami A; Plebani, Mario; Lippi, Giuseppe (2020. ) Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review.Clinical biochemistry, , 81 ,1-8 More Information

Benoit, Justin L; Wang, Henry E (2020. ) Intubation for Out-of-Hospital Cardiac Arrest: The Elephant Is in the Room.Annals of emergency medicine, , 75 (5 ) ,637-639 More Information

Henry, Brandon Michael; de Oliveira, Maria Helena Santos; Benoit, Justin; Lippi, Giuseppe (2020. ) Gastrointestinal symptoms associated with severity of coronavirus disease 2019 (COVID-19): a pooled analysis.Internal and emergency medicine, , More Information

Lippi, Giuseppe; Henry, Brandon Michael; Hoehn, Jonathan; Benoit, Stefanie; Benoit, Justin (2020. ) Validation of the Corona-Score for rapid identification of SARS-CoV-2 infections in patients seeking emergency department care in the United States.Clinical chemistry and laboratory medicine, , More Information

Benoit, Justin; Benoit, Stefanie W; Lippi, Giuseppe; Henry, Brandon Michael (2020. ) False negative RT-PCR or false positive serological testing in SARS-CoV-2 diagnostics? Navigating between Scylla and Charybdis to prevent misclassification bias in COVID-19 clinical investigations.Diagnosis (Berlin, Germany), , More Information

Henry, Brandon Michael; Benoit, Stefanie; Lippi, Giuseppe; Benoit, Justin (2020. ) Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report.Progress in cardiovascular diseases, , More Information

Soar, Jasmeet; Berg, Katherine M; Andersen, Lars W; Böttiger, Bernd W; Cacciola, Sofia; Callaway, Clifton W; Couper, Keith; Cronberg, Tobias; D'Arrigo, Sonia; Deakin, Charles D; Donnino, Michael W; Drennan, Ian R; Granfeldt, Asger; Hoedemaekers, Cornelia W E; Holmberg, Mathias J; Hsu, Cindy H; Kamps, Marlijn; Musiol, Szymon; Nation, Kevin J; Neumar, Robert W; Nicholson, Tonia; O'Neil, Brian J; Otto, Quentin; de Paiva, Edison Ferreira; Parr, Michael J A; Reynolds, Joshua C; Sandroni, Claudio; Scholefield, Barnaby R; Skrifvars, Markus B; Wang, Tzong-Luen; Wetsch, Wolfgang A; Yeung, Joyce; Morley, Peter T; Morrison, Laurie J; Welsford, Michelle; Hazinski, Mary Fran; Nolan, Jerry P (2020. ) Adult Advanced Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations.Resuscitation, , 156 ,A80-A119 More Information

Panchal, Ashish R; Bartos, Jason A; Cabañas, José G; Donnino, Michael W; Drennan, Ian R; Hirsch, Karen G; Kudenchuk, Peter J; Kurz, Michael C; Lavonas, Eric J; Morley, Peter T; O'Neil, Brian J; Peberdy, Mary Ann; Rittenberger, Jon C; Rodriguez, Amber J; Sawyer, Kelly N; Berg, Katherine M (2020. ) Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.Circulation, , 142 (16_suppl_2 ) ,S366-S468 More Information

Neth, Matthew R; Benoit, Justin L; Stolz, Uwe; McMullan, Jason (2020. ) Ventilation in Simulated Out-of-Hospital Cardiac Arrest Resuscitation Rarely Meets Guidelines.Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, , 1-9 More Information

Henry, Brandon Michael; Benoit, Stefanie W; Hoehn, Jonathan; Lippi, Giuseppe; Favaloro, Emmanuel J; Benoit, Justin L (2020. ) Circulating Plasminogen Concentration at Admission in Patients with Coronavirus Disease 2019 (COVID-19).Seminars in thrombosis and hemostasis, , 46 (7 ) ,859-862 More Information

Benoit, Justin L; Benoit, Stefanie W; de Oliveira, Maria H S; Lippi, Giuseppe; Henry, Brandon M (2020. ) Anemia and COVID-19: A prospective perspective.Journal of medical virology, , More Information

Henry, Brandon; Cheruiyot, Isaac; Vikse, Jens; Mutua, Victor; Kipkorir, Vincent; Benoit, Justin; Plebani, Mario; Bragazzi, Nicola; Lippi, Giuseppe (2020. ) Lymphopenia and neutrophilia at admission predicts severity and mortality in patients with COVID-19: a meta-analysis.Acta bio-medica : Atenei Parmensis, , 91 (3 ) ,e2020008 More Information

Henry, Brandon M; Benoit, Justin L; Berger, Brandon A; Pulvino, Christina; Lavie, Carl J; Lippi, Giuseppe; Benoit, Stefanie W (2020. ) Coronavirus disease 2019 is associated with low circulating plasma levels of angiotensin 1 and angiotensin 1,7.Journal of medical virology, , More Information

Henry, Brandon Michael; Benoit, Justin Lee; Benoit, Stefanie; Pulvino, Christina; Berger, Brandon A; Olivera, Maria Helena Santos de; Crutchfield, Christopher A; Lippi, Giuseppe (2020. ) Red Blood Cell Distribution Width (RDW) Predicts COVID-19 Severity: A Prospective, Observational Study from the Cincinnati SARS-CoV-2 Emergency Department Cohort.Diagnostics (Basel, Switzerland), , 10 (9 ) , More Information

Neth, Matthew R; Idris, Ahamed; McMullan, Jason; Benoit, Justin L; Daya, Mohamud R (2020. ) A review of ventilation in adult out-of-hospital cardiac arrest.Journal of the American College of Emergency Physicians open, , 1 (3 ) ,190-201 More Information

Spigner MF; Benoit JL; Menegazzi JJ; McMullan JT (2021. ) Prehospital Protocols for Post-Return of Spontaneous Circulation Are Highly Variable.Prehospital Emergency Care, , More Information

Strong DW, Benoit JL, Calhoun DJ (2017. ) University of Cincinnati Tactical EMS: A Resident Physician Experience .Tactical Edge, , (Winter ) ,72-77

Henry, Brandon Michael; Benoit, Justin L; Rose, James; de Oliveira, Maria Helena Santos; Lippi, Giuseppe; Benoit, Stefanie W (2021. ) Serum ACE activity and plasma ACE concentration in patients with SARS-CoV-2 infection.Scandinavian journal of clinical and laboratory investigation, , 1-4 More Information

Henry, Brandon Michael; Szergyuk, Ivan; de Oliveira, Maria Helena Santos; Lippi, Giuseppe; Benoit, Justin L; Vikse, Jens; Benoit, Stefanie W (2021. ) Complement levels at admission as a reflection of coronavirus disease 2019 (COVID-19) severity state.Journal of medical virology, , More Information

Azouz, Nurit P; Klingler, Andrea M; Callahan, Victoria; Akhrymuk, Ivan V; Elez, Katarina; Raich, Lluís; Henry, Brandon M; Benoit, Justin L; Benoit, Stefanie W; Noé, Frank; Kehn-Hall, Kylene; Rothenberg, Marc E (2021. ) Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2.Pathogens & immunity, , 6 (1 ) ,55-74 More Information

Henry, Brandon M; Szergyuk, Ivan; de Oliveira, Maria Helena Santos; Abosamak, Mohammed Fawzi; Benoit, Stefanie W; Benoit, Justin L; Lippi, Giuseppe (2021. ) Alterations in the lipid profile associate with a dysregulated inflammatory, prothrombotic, anti-fibrinolytic state and development of severe acute kidney injury in coronavirus disease 2019 (COVID-19): A study from Cincinnati, USA.Diabetes & metabolic syndrome, , 15 (3 ) ,863-868 More Information

Henry, Brandon Michael; Cheruiyot, Isaac; Benoit, Stefanie W; Sanchis-Gomar, Fabian; Lippi, Giuseppe; Benoit, Justin (2021. ) Cytokeratin 18 cell death assays as biomarkers for quantification of apoptosis and necrosis in COVID-19: a prospective, observational study.Journal of clinical pathology, , More Information

Henry, Brandon Michael; de Oliveira, Maria Helena Santos; Cheruiyot, Isaac; Benoit, Justin L; Cooper, David S; Lippi, Giuseppe; Le Cras, Timothy D; Benoit, Stefanie W (2021. ) Circulating level of Angiopoietin-2 is associated with acute kidney injury in coronavirus disease 2019 (COVID-19).Angiogenesis, , More Information

Benoit, Justin L; Stolz, Uwe; McMullan, Jason T; Wang, Henry E (2021. ) Duration of exposure to a prehospital advanced airway and neurological outcome for out-of-hospital cardiac arrest: A retrospective cohort study.Resuscitation, , 160 ,59-65 More Information

Henry, Brandon Michael; Cheruiyot, Isaac; Benoit, Justin L; Lippi, Giuseppe; Prohászka, Zoltán; Favaloro, Emmanuel J; Benoit, Stefanie W (2021. ) Circulating Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Are Independent Predictors of Coronavirus Disease 2019 Severity: A Prospective, Observational Study.Seminars in thrombosis and hemostasis, , More Information

Henry, Brandon Michael; Benoit, Stefanie W; de Oliveira, Maria Helena Santos; Lippi, Giuseppe; Favaloro, Emmanuel J; Benoit, Justin L (2020. ) ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID-19: Evidence of SARS-CoV-2 induced secondary thrombotic microangiopathy.International journal of laboratory hematology, , More Information

Henry, Brandon Michael; Benoit, Stefanie W; Vikse, Jens; Berger, Brandon A; Pulvino, Christina; Hoehn, Jonathan; Rose, James; Santos de Oliveira, Maria Helena; Lippi, Giuseppe; Benoit, Justin L (2021. ) The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro-inflammatory cytokine response in coronavirus disease 2019 (COVID-19).Clinical chemistry and laboratory medicine, , 59 (3 ) ,599-607 More Information

Lippi, Giuseppe; Szergyuk, Ivan; de Oliveira, Maria Helena Santos; Benoit, Stefanie W; Benoit, Justin L; Favaloro, Emmanuel J; Henry, Brandon Michael (2021. ) The role of lipoprotein(a) in coronavirus disease 2019 (COVID-19) with relation to development of severe acute kidney injury.Journal of thrombosis and thrombolysis, , More Information

Okubo, Masashi; Komukai, Sho; Izawa, Junichi; Aufderheide, Tom P; Benoit, Justin L; Carlson, Jestin N; Daya, Mohamud R; Hansen, Matthew; Idris, Ahamed H; Le, Nancy; Lupton, Joshua R; Nichol, Graham; Wang, Henry E; Callaway, Clifton W (2021. ) Association of Advanced Airway Insertion Timing and Outcomes After Out-of-Hospital Cardiac Arrest.Annals of emergency medicine, , More Information

Henry, Brandon; Helena, Maria; Cheruiyot, Isaac; Benoit, Stefanie; Benoit, Justin; Lippi, Giuseppe (2021. ) Combined Cytokine Scores Assessed at Emergency Department Presentation Predicts COVID-19 Critical Illness.Acta bio-medica : Atenei Parmensis, , 92 (4 ) ,e2021248 More Information

Benoit J, Benoit S, Rose J, Lippi G, Henry BM (2020. ) Assessment of Immune Response Against SARS-CoV-2 at Emergency Department Evaluation in COVID-19 Patients.Journal of Laboratory and Precision Medicine, , 5 ,33 More Information

Henry, Brandon; Benoit, Stefanie; Vikse, Jens; Favaloro, Emmanuel; Benoit, Justin; Lippi, Giuseppe (2022. ) Anti-Endothelial Cell Antibodies are not frequently elevated in hospitalized patients with COVID-19.Acta bio-medica : Atenei Parmensis, , 93 (2 ) ,e2022043 More Information

Henry, Brandon M; Sinkovits, György; Szergyuk, Ivan; de Oliveira, Maria Helena Santos; Lippi, Giuseppe; Benoit, Justin L; Favaloro, Emmanuel J; Pode-Shakked, Naomi; Benoit, Stefanie W; Cooper, David S; Müller, Veronika; Iványi, Zsolt; Gál, János; Réti, Marienn; Gopcsa, László; Reményi, Péter; Szathmáry, Beáta; Lakatos, Botond; Szlávik, János; Bobek, Ilona; Prohászka, Zita Z; Förhécz, Zsolt; Csuka, Dorottya; Hurler, Lisa; Kajdácsi, Erika; Cervenak, László; Mez?, Blanka; Kiszel, Petra; Masszi, Tamás; Vályi-Nagy, István; Prohászka, Zoltán (2022. ) Complement Levels at Admission Reflecting Progression to Severe Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19): A Multicenter Prospective Cohort Study.Frontiers in medicine, , 9 ,796109 More Information

Henry, Brandon Michael; de Oliveira, Maria Helena Santos; Cheruiyot, Isaac; Benoit, Justin; Rose, James; Favaloro, Emmanuel J; Lippi, Giuseppe; Benoit, Stefanie; Pode Shakked, Naomi (2022. ) Cell-Free DNA, Neutrophil extracellular traps (NETs), and Endothelial Injury in Coronavirus Disease 2019- (COVID-19-) Associated Acute Kidney Injury.Mediators of inflammation, , 2022 ,9339411 More Information

Pode Shakked, Naomi; de Oliveira, Maria Helena Santos; Cheruiyot, Isaac; Benoit, Justin L; Plebani, Mario; Lippi, Giuseppe; Benoit, Stefanie W; Henry, Brandon Michael (2022. ) Early prediction of COVID-19-associated acute kidney injury: Are serum NGAL and serum Cystatin C levels better than serum creatinine?.Clinical biochemistry, , 102 ,1-8 More Information

Puskarich, Michael A; Ingraham, Nicholas E; Merck, Lisa H; Driver, Brian E; Wacker, David A; Black, Lauren Page; Jones, Alan E; Fletcher, Courtney V; South, Andrew M; Murray, Thomas A; Lewandowski, Christopher; Farhat, Joseph; Benoit, Justin L; Biros, Michelle H; Cherabuddi, Kartik; Chipman, Jeffrey G; Schacker, Timothy W; Guirgis, Faheem W; Voelker, Helen T; Koopmeiners, Joseph S; Tignanelli, Christopher J (2022. ) Efficacy of Losartan in Hospitalized Patients With COVID-19-Induced Lung Injury: A Randomized Clinical Trial.JAMA network open, , 5 (3 ) ,e222735 More Information

Counts, Catherine R; Benoit, Justin L; McClelland, Graham; DuCanto, James; Weekes, Lauren; Latimer, Andrew; Hagahmed, Mohamed; Guyette, Francis X (2022. ) Novel Technologies and Techniques for Prehospital Airway Management: An NAEMSP Position Statement and Resource Document.Prehospital emergency care, , 26 (sup1 ) ,129-136 More Information

Azouz, Nurit P; Klingler, Andrea M; Callahan, Victoria; Akhrymuk, Ivan V; Elez, Katarina; Raich, Lluís; Henry, Brandon M; Benoit, Justin L; Benoit, Stefanie W; Noé, Frank; Kehn-Hall, Kylene; Rothenberg, Marc E (2020. ) Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2.bioRxiv : the preprint server for biology, , More Information

Contact Information

Academic - University of Cincinnati College of Medicine
Department of Emergency Medicine
Cincinnati   Ohio, 45267-0769
Phone: 513-558-5281
Fax: 513-558-5791
Justin.Benoit@uc.edu