Temugin Berta

Temugin Berta

Assistant Professor

Medical Sciences Building

3408

COM Anesthesiology Berta Lab - 0531

Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267

Education

Doctoral Degree, University of Lausanne 2008

Post-Doctoral Fellowship, Harvard University 2009

Post-Doctoral Fellowship, Duke University 2012

Research Support

Grant: #R21 NS100469 Investigators:Baccei, Mark; Berta, Temugin; Seroogy, Kim 06-01-2017 -05-30-2019 National Institute of Neurological Disorders and Stroke Identification of novel analgesic targets in ascending spinal projection neurons Role:Collaborator $199,062.00

Grant: #R21NS106264 Investigators:Berta, Temugin; Davidson, Steve 09-01-2018 -08-31-2020 National Institute of Neurological Disorders and Stroke Purification and Characterization of Mature Murine and Human Satellite Glial Cells Role:PI $240,128.00 Active Level:Federal

Grant: #R01NS113243 Investigators:Berta, Temugin; Strong, Judith; Xie, Wen-Rui; Zhang, Jun-Ming 07-01-2019 -05-31-2024 National Institute of Neurological Disorders and Stroke Targeting sensory ganglia and glial signaling for the treatment of acute and chronic pain Role:PI $2,006,250.00 Awarded Level:Federal

Grant: #Discovery Grant Investigators:Berta, Temugin 08-01-2019 -07-31-2020 National Psoriasis Foundation TRANSIENT RECEPTOR POTENTIAL CHANNEL 4 AS A NOVEL TARGET TO RELIEVE PSORIASIS Role:PI $75,000.00 Awarded Level:Private Non-Profit

Publications

Peer Reviewed Publications

Lee, Sang Hoon; Cho, Pyung Sun; Tonello, Raquel; Lee, Han Kyu; Jang, Jun Ho; Park, Gi Yeon; Hwang, Sun Wook; Park, Chul-Kyu; Jung, Sung Jun; Berta, Temugin (2018. ) Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.The Journal of allergy and clinical immunology, ,

Chamessian, Alexander; Young, Michael; Qadri, Yawar; Berta, Temugin; Ji, Ru-Rong; Van de Ven, Thomas (2018. ) Transcriptional Profiling of Somatostatin Interneurons in the Spinal Dorsal Horn.Scientific reports, , 8 (1 ) ,6809

Chang, Wonseok; Berta, Temugin; Kim, Yong Ho; Lee, Sanghoon; Lee, Seok-Yong; Ji, Ru-Rong (2018. ) Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel.Neuroscience bulletin, , 34 (1 ) ,4-12

Berta, Temugin; Perrin, Florence E; Pertin, Marie; Tonello, Raquel; Liu, Yen-Chin; Chamessian, Alexander; Kato, Ann C; Ji, Ru-Rong; Decosterd, Isabelle (2017. ) Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.Scientific reports, , 7 (1 ) ,9367

Berta, Temugin; Qadri, Yawar; Tan, Ping-Heng; Ji, Ru-Rong (2017. ) Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain.Expert opinion on therapeutic targets, , 21 (7 ) ,695-703

Xu, Zhen-Zhong; Kim, Yong Ho; Bang, Sangsu; Zhang, Yi; Berta, Temugin; Wang, Fan; Oh, Seog Bae; Ji, Ru-Rong (2015. ) Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade.Nature medicine, , 21 (11 ) ,1326-31

McKelvey, Rebecca; Berta, Temugin; Old, Elizabeth; Ji, Ru-Rong; Fitzgerald, Maria (2015. ) Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 35 (2 ) ,457-66

Liu, Xing-Jun; Zhang, Yanli; Liu, Tong; Xu, Zhen-Zhong; Park, Chul-Kyu; Berta, Temugin; Jiang, Dianhua; Ji, Ru-Rong (2014. ) Nociceptive neurons regulate innate and adaptive immunity and neuropathic pain through MyD88 adapter.Cell research, , 24 (11 ) ,1374-7

Park, Chul-Kyu; Xu, Zhen-Zhong; Berta, Temugin; Han, Qingjian; Chen, Gang; Liu, Xing-Jun; Ji, Ru-Rong (2014. ) Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.Neuron, , 82 (1 ) ,47-54

Berta, Temugin; Park, Chul-Kyu; Xu, Zhen-Zhong; Xie, Ruo-Gang; Liu, Tong; Lü, Ning; Liu, Yen-Chin; Ji, Ru-Rong (2014. ) Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-? secretion.The Journal of clinical investigation, , 124 (3 ) ,1173-86

Ji, Ru-Rong; Berta, Temugin; Nedergaard, Maiken (2013. ) Glia and pain: is chronic pain a gliopathy?.Pain, , 154 Suppl 1 ,S10-28

Liu, Tong; Berta, Temugin; Xu, Zhen-Zhong; Park, Chul-Kyu; Zhang, Ling; Lü, Ning; Liu, Qin; Liu, Yang; Gao, Yong-Jing; Liu, Yen-Chin; Ma, Qiufu; Dong, Xinzhong; Ji, Ru-Rong (2012. ) TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice.The Journal of clinical investigation, , 122 (6 ) ,2195-207

Xu, Zhen-Zhong; Zhang, Ling; Liu, Tong; Park, Jong Yeon; Berta, Temugin; Yang, Rong; Serhan, Charles N; Ji, Ru-Rong (2010. ) Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.Nature medicine, , 16 (5 ) ,592-7, 1p following

Tonello, Raquel; Xie, Wenrui; Lee, Sang Hoon; Wang, Min; Liu, Xiaojuan; Strong, Judith A; Zhang, Jun-Ming; Berta, Temugin (2020. ) Local Sympathectomy Promotes Antiinflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice.Anesthesiology, ,

Gattlen, Christophe; Deftu, Alexandru-Florian; Tonello, Raquel; Ling, Yuejuan; Berta, Temugin; Ristoiu, Violeta; Suter, Marc René (2020. ) The inhibition of Kir2.1 potassium channels depolarizes spinal microglial cells, reduces their proliferation, and attenuates neuropathic pain.Glia, ,

Liu, Xiaojuan; Tonello, Raquel; Ling, Yuejuan; Gao, Yong-Jing; Berta, Temugin (2019. ) Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-? and stromal-derived cell factor 1.Journal of neuroinflammation, , 16 (1 ) ,209

Serafin, Elizabeth K; Chamessian, Alexander; Li, Jie; Zhang, Xiang; McGann, Amanda; Brewer, Chelsie L; Berta, Temugin; Baccei, Mark (2019. ) Transcriptional profile of spinal dynorphin-lineage interneurons in the developing mouse.Pain, , 160 (10 ) ,2380-2397

Tonello, Raquel; Lee, Sang Hoon; Berta, Temugin (2019. ) Monoclonal Antibody Targeting the Matrix Metalloproteinase 9 Prevents and Reverses Paclitaxel-Induced Peripheral Neuropathy in Mice.The journal of pain : official journal of the American Pain Society, , 20 (5 ) ,515-527

Ibrahim, Shaimaa I A; Xie, Wenrui; Strong, Judith A; Tonello, Raquel; Berta, Temugin; Zhang, Jun-Ming (2018. ) Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain.Frontiers in cellular neuroscience, , 12 ,453

Song, Zongbin; Xie, Wenrui; Strong, Judith A; Berta, Temugin; Ulrich-Lai, Yvonne M; Guo, Qulian; Zhang, Jun-Ming (2018. ) High-fat diet exacerbates postoperative pain and inflammation in a sex-dependent manner.Pain, , 159 (9 ) ,1731-1741

Priebe, Alaini; Hunke, Megan; Tonello, Raquel; Sonawane, Yogesh; Berta, Temugin; Natarajan, Amarnath; Bhuvanesh, Nattamai; Pattabiraman, Mahesh; Chandra, Surabhi (2018. ) Ferulic acid dimer as a non-opioid therapeutic for acute pain.Journal of pain research, , 11 ,1075-1085

Chen, Gang; Luo, Xin; Qadri, M Yawar; Berta, Temugin; Ji, Ru-Rong (2018. ) Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes.Neuroscience bulletin, , 34 (1 ) ,98-108

Chamessian, Alexander G; Qadri, Yawar J; Cummins, Matthew; Hendrickson, Michele; Berta, Temugin; Buchheit, Thomas; Van de Ven, Thomas (2017. ) 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain.Somatosensory & motor research, , 34 (2 ) ,72-79

Berta, Temugin; Lee, Jee Eun; Park, Chul-Kyu (2017. ) Unconventional Role of Caspase-6 in Spinal Microglia Activation and Chronic Pain.Mediators of inflammation, , 2017 ,9383184

Han, Qingjian; Kim, Yong Ho; Wang, Xiaoming; Liu, Di; Zhang, Zhi-Jun; Bey, Alexandra L; Lay, Mark; Chang, Wonseok; Berta, Temugin; Zhang, Yan; Jiang, Yong-Hui; Ji, Ru-Rong (2016. ) SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.Neuron, , 92 (6 ) ,1279-1293

Liu, Chien-Cheng; Gao, Yong-Jing; Luo, Hao; Berta, Temugin; Xu, Zhen-Zhong; Ji, Ru-Rong; Tan, Ping-Heng (2016. ) Interferon alpha inhibits spinal cord synaptic and nociceptive transmission via neuronal-glial interactions.Scientific reports, , 6 ,34356

Berta, T; Qadri, Y J; Chen, G; Ji, R R (2016. ) Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence.Journal of dental research, , 95 (10 ) ,1124-31

Chen, Gang; Xie, Rou-Gang; Gao, Yong-Jing; Xu, Zhen-Zhong; Zhao, Lin-Xia; Bang, Sangsu; Berta, Temugin; Park, Chul-Kyu; Lay, Mark; Chen, Wei; Ji, Ru-Rong (2016. ) ?-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.Nature communications, , 7 ,12531

Taves, Sarah; Berta, Temugin; Liu, Da-Lu; Gan, Sophie; Chen, Gang; Kim, Yong Ho; Van de Ven, Thomas; Laufer, Stefan; Ji, Ru-Rong (2016. ) Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord.Brain, behavior, and immunity, , 55 ,70-81

Martini, Alessandra Cadete; Berta, Temugin; Forner, Stefânia; Chen, Gang; Bento, Allisson Freire; Ji, Ru-Rong; Rae, Giles Alexander (2016. ) Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection.Journal of neuroinflammation, , 13 (1 ) ,75

Liu, Tong; Han, Qingjian; Chen, Gang; Huang, Ya; Zhao, Lin-Xia; Berta, Temugin; Gao, Yong-Jing; Ji, Ru-Rong (2016. ) Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice.Pain, , 157 (4 ) ,806-17

Jiang, Bao-Chun; Cao, De-Li; Zhang, Xin; Zhang, Zhi-Jun; He, Li-Na; Li, Chun-Hua; Zhang, Wen-Wen; Wu, Xiao-Bo; Berta, Temugin; Ji, Ru-Rong; Gao, Yong-Jing (2016. ) CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5.The Journal of clinical investigation, , 126 (2 ) ,745-61

Soens, Mieke; Wang, Jeffrey C-F; Berta, Temugin; Strichartz, Gary (2015. ) Systemic Progesterone Administration in Early Life Alters the Hyperalgesic Responses to Surgery in the Adult: A Study on Female Rats.Anesthesia and analgesia, , 121 (2 ) ,545-55

Chen, Gang; Park, Chul-Kyu; Xie, Rou-Gang; Berta, Temugin; Nedergaard, Maiken; Ji, Ru-Rong (2014. ) Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.Brain : a journal of neurology, , 137 (Pt 8 ) ,2193-209

Berta, T; Liu, Y-C; Xu, Z-Z; Ji, R-R (2013. ) Tissue plasminogen activator contributes to morphine tolerance and induces mechanical allodynia via astrocytic IL-1? and ERK signaling in the spinal cord of mice.Neuroscience, , 247 ,376-85

Xu, Zhen-Zhong; Liu, Xing-Jun; Berta, Temugin; Park, Chul-Kyu; Lü, Ning; Serhan, Charles N; Ji, Ru-Rong (2013. ) Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma.Annals of neurology, , 74 (3 ) ,490-5

Xu, Zhen-Zhong; Berta, Temugin; Ji, Ru-Rong (2013. ) Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , 8 (1 ) ,37-41

Taves, Sarah; Berta, Temugin; Chen, Gang; Ji, Ru-Rong (2013. ) Microglia and spinal cord synaptic plasticity in persistent pain.Neural plasticity, , 2013 ,753656

Tan, P H; Gao, Y J; Berta, T; Xu, Z Z; Ji, R R (2012. ) Short small-interfering RNAs produce interferon-?-mediated analgesia.British journal of anaesthesia, , 108 (4 ) ,662-9

Liu, Yen-Chin; Berta, Temugin; Liu, Tong; Tan, Ping-Heng; Ji, Ru-Rong (2012. ) Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice.Molecular pain, , 8 ,19

Berta, Temugin; Liu, Tong; Liu, Yen-Chin; Xu, Zhen-Zhong; Ji, Ru-Rong (2012. ) Acute morphine activates satellite glial cells and up-regulates IL-1? in dorsal root ganglia in mice via matrix metalloprotease-9.Molecular pain, , 8 ,18

Zhang, Ling; Berta, Temugin; Xu, Zhen-Zhong; Liu, Tong; Park, Jong Yeon; Ji, Ru-Rong (2011. ) TNF-? contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2.Pain, , 152 (2 ) ,419-27

Liu, Tong; Xu, Zhen-Zhong; Park, Chul-Kyu; Berta, Temugin; Ji, Ru-Rong (2010. ) Toll-like receptor 7 mediates pruritus.Nature neuroscience, , 13 (12 ) ,1460-2

Suter, Marc R; Berta, Temugin; Gao, Yong-Jing; Decosterd, Isabelle; Ji, Ru-Rong (2009. ) Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury.Molecular pain, , 5 ,53

Berta, Temugin; Poirot, Olivier; Pertin, Marie; Ji, Ru-Rong; Kellenberger, Stephan; Decosterd, Isabelle (2008. ) Transcriptional and functional profiles of voltage-gated Na(+) channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain.Molecular and cellular neurosciences, , 37 (2 ) ,196-208

Poirot, Olivier; Berta, Temugin; Decosterd, Isabelle; Kellenberger, Stephan (2006. ) Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury.The Journal of physiology, , 576 (Pt 1 ) ,215-34

Pertin, Marie; Ji, Ru-Rong; Berta, Temugin; Powell, Andrew J; Karchewski, Laurie; Tate, Simon N; Isom, Lori L; Woolf, Clifford J; Gilliard, Nicolas; Spahn, Donat R; Decosterd, Isabelle (2005. ) Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 25 (47 ) ,10970-80

Girard, P; Porte, L; Berta, T; Jordan, M; Wurm, F M (2001. ) Calcium phosphate transfection optimization for serum-free suspension culture.Cytotechnology, , 35 (3 ) ,175-80

Contact Information

Academic - Medical Sciences Building
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 5135583424
temugin.berta@uc.edu