Erik Bey , PHD

2008 -2011 Instructor, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Dallas, Texas

2011 -2019 Assistant Professor, School of Pharmacy, School of Medicine, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV

2019 -2022 Associate Professor (Research Track), Investigator and Associate Professor of Biochemistry and Molecular Genetics., Indiana University's School of Medicine, Department of Biochemistry and Molecular Genetics, Indianapolis, IN

07-01-2022 -07-30-2024 Senior Staff Scientist, Taught undergraduates cancer biology techniques in a laboratory setting., Wood-Hudson Cancer Research Laboratory, Newport, Kentucky

Peer Reviewed Publications

Raddatz, Andrew D; Furdui, Cristina M; Bey, Erik A; Kemp, Melissa L (2023. ) Single-Cell Kinetic Modeling of β-Lapachone Metabolism in Head and Neck Squamous Cell Carcinoma.Antioxidants (Basel, Switzerland), , 12 (3 ) , More Information

Madajewski, Brian; Boatman, Michael A; Martinez, Ivan; Carter, Julia H; Bey, Erik A (2023. ) NAD(P)H Quinone Oxidoreductase-1 Expression Promotes Self-Renewal and Therapeutic Resistance in Non-Small Cell Lung Cancer.Genes, , 14 (3 ) , More Information

Brownmiller, Tayvia; Juric, Jamie A; Ivey, Abby D; Harvey, Brandon M; Westemeier, Emily S; Winters, Michael T; Stevens, Alyson M; Stanley, Alana N; Hayes, Karen E; Sprowls, Samuel A; Ammer, Amanda S Gatesman; Walker, Mackenzee; Bey, Erik A; Wu, Xiaoliang; Lim, Zuan-Fu; Zhu, Lin; Wen, Sijin; Hu, Gangqing; Ma, Patrick C; Martinez, Ivan (2020. ) Y Chromosome LncRNA Are Involved in Radiation Response of Male Non-Small Cell Lung Cancer Cells.Cancer research, , 80 (19 ) ,4046-4057 More Information

Starcher, Colton L; Pay, S Louise; Singh, Naveen; Yeh, I-Ju; Bhandare, Snehal B; Su, Xiaolin; Huang, Xiumei; Bey, Erik A; Motea, Edward A; Boothman, David A (2020. ) Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer.Frontiers in oncology, , 10 ,1575 More Information

Motea, Edward A; Huang, Xiumei; Singh, Naveen; Kilgore, Jessica A; Williams, Noelle S; Xie, Xian-Jin; Gerber, David E; Beg, Muhammad S; Bey, Erik A; Boothman, David A (2019. ) NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research, , 25 (8 ) ,2601-2609 More Information

Huang, Xiumei; Motea, Edward A; Moore, Zachary R; Yao, Jun; Dong, Ying; Chakrabarti, Gaurab; Kilgore, Jessica A; Silvers, Molly A; Patidar, Praveen L; Cholka, Agnieszka; Fattah, Farjana; Cha, Yoonjeong; Anderson, Glenda G; Kusko, Rebecca; Peyton, Michael; Yan, Jingsheng; Xie, Xian-Jin; Sarode, Venetia; Williams, Noelle S; Minna, John D; Beg, Muhammad; Gerber, David E; Bey, Erik A; Boothman, David A (2016. ) Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors.Cancer cell, , 30 (6 ) ,940-952 More Information

Madajewski, Brian; Boatman, Michael A; Chakrabarti, Gaurab; Boothman, David A; Bey, Erik A (2016. ) Depleting Tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC.Molecular cancer research : MCR, , 14 (1 ) ,14-25 More Information

Cao, Lifen; Li, Long Shan; Spruell, Christopher; Xiao, Ling; Chakrabarti, Gaurab; Bey, Erik A; Reinicke, Kathryn E; Srougi, Melissa C; Moore, Zachary; Dong, Ying; Vo, Peggy; Kabbani, Wareef; Yang, Chin-Rang; Wang, Xiaoyu; Fattah, Farjana; Morales, Julio C; Motea, Edward A; Bornmann, William G; Yordy, John S; Boothman, David A (2014. ) Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.Antioxidants & redox signaling, , 21 (2 ) ,237-50 More Information

Morales, Julio; Li, Longshan; Fattah, Farjana J; Dong, Ying; Bey, Erik A; Patel, Malina; Gao, Jinming; Boothman, David A (2014. ) Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.Critical reviews in eukaryotic gene expression, , 24 (1 ) ,15-28 More Information

Bey, Erik A; Reinicke, Kathryn E; Srougi, Melissa C; Varnes, Marie; Anderson, Vernon E; Pink, John J; Li, Long Shan; Patel, Malina; Cao, Lifen; Moore, Zachary; Rommel, Amy; Boatman, Michael; Lewis, Cheryl; Euhus, David M; Bornmann, William G; Buchsbaum, Donald J; Spitz, Douglas R; Gao, Jinming; Boothman, David A (2013. ) Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.Molecular cancer therapeutics, , 12 (10 ) ,2110-20 More Information

Lo, Karen K; Bey, Erik A; Patra, Biswantha; Benson, Douglas D; Boothman, David A; Silliman, Christopher C; Barnett, Carlton C (2013. ) Hemoglobin-based oxygen carrier mitigates transfusion-mediated pancreas cancer progression.Annals of surgical oncology, , 20 (6 ) ,2073-7 More Information

Huang, Gang; Chen, Huabing; Dong, Ying; Luo, Xiuquan; Yu, Haijun; Moore, Zachary; Bey, Erik A; Boothman, David A; Gao, Jinming (2013. ) Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy.Theranostics, , 3 (2 ) ,116-26 More Information

Huang, Xiumei; Dong, Ying; Bey, Erik A; Kilgore, Jessica A; Bair, Joseph S; Li, Long-Shan; Patel, Malina; Parkinson, Elizabeth I; Wang, Yiguang; Williams, Noelle S; Gao, Jinming; Hergenrother, Paul J; Boothman, David A (2012. ) An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.Cancer research, , 72 (12 ) ,3038-47 More Information

Li, Long Shan; Bey, Erik A; Dong, Ying; Meng, Jieru; Patra, Biswanath; Yan, Jingsheng; Xie, Xian-Jin; Brekken, Rolf A; Barnett, Carlton C; Bornmann, William G; Gao, Jinming; Boothman, David A (2011. ) Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.Clinical cancer research : an official journal of the American Association for Cancer Research, , 17 (2 ) ,275-85 More Information

Dong, Ying; Bey, Erik A; Li, Long-Shan; Kabbani, Wareef; Yan, Jingsheng; Xie, Xian-Jin; Hsieh, Jer-Tsong; Gao, Jinming; Boothman, David A (2010. ) Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.Cancer research, , 70 (20 ) ,8088-96 More Information

Blanco, Elvin; Bey, Erik A; Khemtong, Chalermchai; Yang, Su-Geun; Setti-Guthi, Jagadeesh; Chen, Huabing; Kessinger, Chase W; Carnevale, Kevin A; Bornmann, William G; Boothman, David A; Gao, Jinming (2010. ) Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.Cancer research, , 70 (10 ) ,3896-904 More Information

Konstantinidou, Georgia; Bey, Erik A; Rabellino, Andrea; Schuster, Katja; Maira, Michael S; Gazdar, Adi F; Amici, Augusto; Boothman, David A; Scaglioni, Pier Paolo (2009. ) Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.Cancer research, , 69 (19 ) ,7644-52 More Information

Khemtong, Chalermchai; Kessinger, Chase W; Ren, Jimin; Bey, Erik A; Yang, Su-Geun; Guthi, Jagadeesh Setti; Boothman, David A; Sherry, A Dean; Gao, Jinming (2009. ) In vivo off-resonance saturation magnetic resonance imaging of alphavbeta3-targeted superparamagnetic nanoparticles.Cancer research, , 69 (4 ) ,1651-8 More Information

Dong, Ying; Chin, Shook-Fong; Blanco, Elvin; Bey, Erik A; Kabbani, Wareef; Xie, Xian-Jin; Bornmann, William G; Boothman, David A; Gao, Jinming (2009. ) Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy.Clinical cancer research : an official journal of the American Association for Cancer Research, , 15 (1 ) ,131-9 More Information

Blanco, Elvin; Bey, Erik A; Dong, Ying; Weinberg, Brent D; Sutton, Damon M; Boothman, David A; Gao, Jinming (2007. ) Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells.Journal of controlled release : official journal of the Controlled Release Society, , 122 (3 ) ,365-74 More Information

Bentle, Melissa S; Reinicke, Kathryn E; Dong, Ying; Bey, Erik A; Boothman, David A (2007. ) Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.Cancer research, , 67 (14 ) ,6936-45 More Information

Bey, Erik A; Bentle, Melissa S; Reinicke, Kathryn E; Dong, Ying; Yang, Chin-Rang; Girard, Luc; Minna, John D; Bornmann, William G; Gao, Jinming; Boothman, David A (2007. ) An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.Proceedings of the National Academy of Sciences of the United States of America, , 104 (28 ) ,11832-7 More Information

Bey, Erik A; Wuerzberger-Davis, Shelly M; Pink, John J; Yang, Chin-Rang; Araki, Shinako; Reinicke, Kathryn E; Bentle, Melissa S; Dong, Ying; Cataldo, Eva; Criswell, Tracy L; Wagner, Mark W; Li, Longshan; Gao, Jinming; Boothman, David A (2006. ) Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses.Journal of cellular physiology, , 209 (3 ) ,604-10 More Information

Bentle, Melissa S; Reinicke, Kathryn E; Bey, Erik A; Spitz, Douglas R; Boothman, David A (2006. ) Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.The Journal of biological chemistry, , 281 (44 ) ,33684-96 More Information

Bentle, Melissa S; Bey, Erik A; Dong, Ying; Reinicke, Kathryn E; Boothman, David A (2006. ) New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors.Journal of molecular histology, , 37 (5-7 ) ,203-18 More Information

Reinicke, Kathryn E; Bey, Erik A; Bentle, Melissa S; Pink, John J; Ingalls, Stephen T; Hoppel, Charles L; Misico, Rosana I; Arzac, Gisela M; Burton, Gerardo; Bornmann, William G; Sutton, Damon; Gao, Jinming; Boothman, David A (2005. ) Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.Clinical cancer research : an official journal of the American Association for Cancer Research, , 11 (8 ) ,3055-64 More Information

Ough, Matthew; Lewis, Anne; Bey, Erik A; Gao, Jinming; Ritchie, Justine M; Bornmann, William; Boothman, David A; Oberley, Larry W; Cullen, Joseph J (2005. ) Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.Cancer biology & therapy, , 4 (1 ) ,95-102 More Information

Park, Heon Joo; Ahn, Ki-Jung; Ahn, Seung-Do; Choi, Eunkyung; Lee, Sang Wook; Williams, Brent; Kim, Eun Jung; Griffin, Robert; Bey, Erik A; Bornmann, William G; Gao, Jinming; Park, Heon Jin; Boothman, David A; Song, Chang W (2005. ) Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation.International journal of radiation oncology, biology, physics, , 61 (1 ) ,212-9 More Information

Bey, Erik A; Xu, Bo; Bhattacharjee, Ashish; Oldfield, Claudine M; Zhao, Xiaoxian; Li, Qing; Subbulakshmi, Venkita; Feldman, Gerald M; Wientjes, Frans B; Cathcart, Martha K (2004. ) Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes.Journal of immunology (Baltimore, Md. : 1950), , 173 (9 ) ,5730-8 More Information

Zhao, Xiaoxian; Bey, Erik A; Wientjes, Frans B; Cathcart, Martha K (2002. ) Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox).The Journal of biological chemistry, , 277 (28 ) ,25385-92 More Information

Bey, Erik A; Cathcart, Martha K (2002. ) Antisense oligodeoxyribonucleotides: a better way to inhibit monocyte superoxide anion production?.Methods in enzymology, , 353 ,421-34 More Information

Bey, E A; Cathcart, M K (2000. ) In vitro knockout of human p47phox blocks superoxide anion production and LDL oxidation by activated human monocytes. Journal of lipid research, , 41 (3 ) ,489-95

Koros, A M; Bey, E A; Conley, S L; Rogers, B W (1994. ) Phenotypic differences among morphologically similar small-cell carcinomas detected with a panel of monoclonal antibodies and indirect immunofluorescence and flow cytometry.International journal of cancer. Supplement = Journal international du cancer. Supplement, , 8 ,127-31 More Information

1994-2001 Ph.D., Cell Biology, Cleveland Clinic Research Foundation/Cleveland State, , Cleveland, Ohio

2002-2005 Post Doctoral Fellow, Case Comprehensive Cancer Center, , Cleveland, Ohio

2005-2008 Post Doctoral Fellow II, University of Texas Southwestern Medical Center, Dallas, , Dallas, Texas