Vladimir Bogdanov

Vladimir Bogdanov

Associate Professor , Director, Hemostasis Research Program

Vontz Center

1316

COM IM Hematology/Oncology Division - 0508

Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati, Ohio 45267-0508

Education

Bachelor's Degree, I.P. Pavlov State Medical University of St. Petersburg 1990 (Medicine)

Master's Degree, Mount Sinai School of Medicine 1996 (Biomedical Sciences/Molecular Biology)

Doctoral Degree, Mount Sinai School of Medicine 1999 (Biomedical Sciences/Molecular Biology)

Fellowship , Mount Sinai School of Medicine 2002 (Division of Thrombosis Research )

Positions and Work Experience

1999 -2002 Research Associate, Division of Thrombosis Research, The Samuel Bronfman Department of Medicine Mount Sinai School of Medicine of NYU, New York, NY

2003 -2009 Assistant Professor of Medicine, Division of Hematology and Medical Oncology / The Tisch Cancer Institute, The Samuel Bronfman Department of Medicine Mount Sinai School of Medicine of NYU, New York, NY

2009 -To Present Assistant Professor of Medicine, Director, Hemostasis Research Program; Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

2009 -To Present Adjunct Assistant Professor of Medicine, Division of Hematology and Medical Oncology / The Tisch Cancer Institute, The Samuel Bronfman Department of Medicine Mount Sinai School of Medicine of NYU, New York, NY

Research and Practice Interests

Blood coagulation system plays many important roles in health and disease.  Aside from clotting blood, coagulation proteases also contribute to such processes as angiogenesis and cellular proliferation / migration.  I direct Hemostasis Research Program in the Division of Hematology/Oncology.  At the present time, the Program is focused on two areas: I. Alternatively spliced Tissue Factor (asTF) as a therapeutic target in pancreatic cancer.  asTF is a soluble form of Tissue Factor (TF), the trigger of blood clotting.  We recently reported that asTF is elevated in pancreatic cancer and acts as a cell agonist promoting growth and spread of pancreatic cancer cells.  Our newly developed inhibitory antibody against asTF is currently being tested in animal models.  II. Red blood cells (RBC) as novel contributors to vascular dysfunction in acute and chronic inflammatory states.  We discovered that RBC can contribute to heightened clotting and obesity-related atherosclerosis, in large part because the levels of pro-inflammatory chemokines bound to RBC become high due to high-fat diet.  We hope that these observations will improve our understanding of RBC biology, and help develop new diagnostic and/or therapeutic strategies aimed at ameliorating obesity-related vascular disease.
Key collaborators: Nigel Mackman, Ph.D., UNC Chapel Hill; Henri Versteeg, PhD, Leiden University; Xiaoyang Qi, Ph.D., University of Cincinnati; Neal Weintraub, M.D., Georgia Regents University; Theodosia Kalfa, M.D., Ph.D., Cincinnati Children’s Hospital and Medical Center.
Blood coagulation system plays many important roles in health and disease.  Aside from clotting blood, coagulation proteases also contribute to such processes as angiogenesis and cellular proliferation / migration.  I direct Hemostasis Research Program in the Division of Hematology/Oncology.  At the present time, the Program is focused on two areas: I. Alternatively spliced Tissue Factor (asTF) as a therapeutic target in pancreatic cancer.  asTF is a soluble form of Tissue Factor (TF), the trigger of blood clotting.  We recently reported that asTF is elevated in pancreatic cancer and acts as a cell agonist promoting growth and spread of pancreatic cancer cells.  Our newly developed inhibitory antibody against asTF is currently being tested in animal models.  II. Red blood cells (RBC) as novel contributors to vascular dysfunction in acute and chronic inflammatory states.  We discovered that RBC can contribute to heightened clotting and obesity-related atherosclerosis, in large part because the levels of pro-inflammatory chemokines bound to RBC become high due to high-fat diet.  We hope that these observations will improve our understanding of RBC biology, and help develop new diagnostic and/or therapeutic strategies aimed at ameliorating obesity-related vascular disease.

Key collaborators: Nigel Mackman, Ph.D., UNC Chapel Hill; Henri Versteeg, PhD, Leiden University; Xiaoyang Qi, Ph.D., University of Cincinnati; Neal Weintraub, M.D., Georgia Regents University; Theodosia Kalfa, M.D., Ph.D., Cincinnati Children’s Hospital and Medical Center.

Research Support

Grant: #1R21CA160293-01A1 Investigators:Vladimir Bogdanov 07-11-2012 -06-30-2013 NIH Tissue Factor splicing and pancreatic tumor progression: pilot studies Role:PI 512000 Active

Investigators:Bogdanov 07-01-2012 -06-30-2013 University of Cincinnati Alternatively Spliced Tissue Factor: a Novel Biomarker and Therapeutic Target in PDAC Management Role:PI 20,678 Active Type:Grant

Grant: #HL094891-01A1 08-14-2009 -07-31-2011 R21/NHLBI - Exploratory Research Program Inducible Transgenes Expressing EJC Enriched mRNAs: a Post-Genomic Innovation Role:PI $428,145

Grant: #DK065752-01 02-07-2005 -01-31-2009 K01/NIDDK - Special Emphasis Research Career Development Award Expression of Alternatively Spliced Human Tissue Factor Role:PI $453,136

Grant: #R01 HL094891 Investigators:Bogdanov, Vladimir 08-15-2009 -07-31-2011 National Heart, Lung and Blood Institute Inducible Transgenes Expressing EJC Enriched mRNAs Role:PI $428,145.00 Closed Level:Federal

Grant: #R21CA160293 Investigators:Bogdanov, Vladimir; Qi, Xiaoyang; Shukla, Rakesh 07-11-2012 -06-30-2014 National Cancer Institute Tissue Factor Splicing and Pancreatic Tumor Progression: Pilot Studies Role:PI $363,330.00 Active Level:Federal

Grant: #R01CA190717 Investigators:Bogdanov, Vladimir 04-09-2015 -03-31-2020 National Institutes of Health Alternatively Spliced Tissue Factor and Pathobiology of Pancreatic Cancer Role:PI $290,978.00 Awarded Level:Federal

Grant: #17-65-BOGD Investigators:Ahmad, Syed; Bogdanov, Vladimir; Desai, Pankaj 07-01-2017 -06-30-2019 Pancreatic Cancer Network Disrupting Tissue Factor-beta1 integrin axis in pancreatic cancer Role:PI $300,000.00 Active Level:Private Non-Profit

Grant: #T32CA236764-01 Investigators:Bogdanov, Vladimir; Qi, Xiaoyang 07-05-2019 -06-30-2024 National Cancer Institute Post-Graduate Hematology/Oncology Translational (PG-HOT) Training Program Role:PI $296,167.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Wang, Jian-Guo; Geddings, Julia E; Aleman, Maria M; Cardenas, Jessica C; Chantrathammachart, Pichika; Williams, Julie C; Kirchhofer, Daniel; Bogdanov, Vladimir Y; Bach, Ronald R; Rak, Janusz; Church, Frank C; Wolberg, Alisa S; Pawlinski, Rafal; Key, Nigel S; Yeh, Jen Jen; Mackman, Nigel (2012. ) Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.Blood, , 119 (23 ) ,5543-52

Ekser, Burcin; Lin, Chih C; Long, Cassandra; Echeverri, Gabriel J; Hara, Hidetaka; Ezzelarab, Mohamed; Bogdanov, Vladimir Y; Stolz, Donna B; Enjyoji, Keiichi; Robson, Simon C; Ayares, David; Dorling, Anthony; Cooper, David K C; Gridelli, Bruno (2012. ) Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation, ,

Lingrel, Jerry B; Pilcher-Roberts, Robyn; Basford, Joshua E; Manoharan, Palanikumar; Neumann, Jon; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Hui, David Y (2012. ) Myeloid-specific kruppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis.Circulation research, , 110 (10 ) ,1294-302

Srinivasan, Ramprasad; Bogdanov, Vladimir Y (2012. ) Splice variants of Tissue Factor and integrin-mediated signaling.Thrombosis research, , 129 Suppl 2 ,S34-7

Godby, Richard C; Van Den Berg, Yascha W; Srinivasan, Ramprasad; Sturm, Robert; Hui, David Y; Konieczny, Stephen F; Aronow, Bruce J; Ozhegov, Evgeny; Ruf, Wolfram; Versteeg, Henri H; Bogdanov, Vladimir Y (2012. ) Non-Proteolytic Properties of Murine Alternatively Spliced Tissue Factor: Implications for Integrin-Mediated Signaling in Murine Models.Molecular medicine (Cambridge, Mass.), ,

Basavaraj, Manjunath Goolyam; Sovershaev, Mikhail A; Egorina, Elena M; Gruber, Franz X; Bogdanov, Vladimir Y; Fallon, John T; Østerud, Bjarne; Mathiesen, Ellisiv B; Hansen, John-Bjarne (2012. ) Circulating monocytes mirror the imbalance in TF and TFPI expression in carotid atherosclerotic plaques with lipid-rich and calcified morphology.Thrombosis research, , 129 (4 ) ,e134-41

Srinivasan, R., Turner, K., Unruh, D., Qi, X., Chu, Z, Aronow, B.J., Kalthoff, H., Ozhegov, E., Kirchhofer, D., Ruf, W., Versteeg, H.H., Ahmad, S., Lucas, F.V., Bogdanov, V.Y. (2012. ) Alternatively Spliced Tissue Factor Contributes to Tumor Spread and Activation of Coagulation in Pancreatic Ductal Adenocarcinoma .International Journal of Cancer, ,

Srinivasan, R., Ozhegov, E., van den Berg, Y.W., Aronow, B.J., Franco, R.S., Palascak, M.B., Fallon, J.T., Ruf, W., Versteeg, H.H., Bogdanov, V.Y. (2011. ) Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling .Journal of Thrombosis and Haemostasis, , 9(10): ,2087-96

Egorina, Elena M; Sovershaev, Mikhail A; Bogdanov, Vladimir Y; Sovershaev, Timofey A; Fallon, John T; Seredkina, Natalia; Østerud, Bjarne; Hansen, John-Bjarne (2011. ) Low thrombogenicity of calcified atherosclerotic plaques is associated with bone morphogenetic protein-2-dependent inhibition of tissue factor expression.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, , 22 (8 ) ,642-50

Srinivasan, Ramprasad; Bogdanov, Vladimir Y (2011. ) Alternatively spliced Tissue Factor: discovery, insights, clinical implications. Frontiers in bioscience : a journal and virtual library, , 17 ,3061-71

Bogdanov, Vladimir Y; Osterud, Bjarne (2010. ) Cardiovascular complications of diabetes mellitus: The Tissue Factor perspective.Thrombosis research, , 125 (2 ) ,112-8

Chandradas, Sajiv; Deikus, Gintaras; Tardos, Jonathan G; Bogdanov, Vladimir Y (2010. ) Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells.Journal of leukocyte biology, , 87 (1 ) ,147-52

Sovershaev, M.A., Egorina, E.M., Bogdanov, V.Y., Seredkina, N., Fallon, J.T., Valkov, A.Y. Osterud, B., & Hansen, J.B. (2010. ) Bone morphogenetic protein-7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor .Thrombosis Research,, , 126 (4: ) ,306-10

Bogdanov, V.Y., Cimmio, G., Tardos, J.G., Tunstead, J.R., and Badimon, J.J. (2009. ) Assessment of Plasma Tissue Factor Activity in Patients Presenting with Coronary Artery Disease: Limitations of a Commercial Assay .Journal of Thrombosis and Haemostasis, , Vol.7, (No. 5 ) ,pp. 894-897

van den Berg, Y.W., van den Hengel, L.G., Myers, H.R., Ayachi, O., Jordanova, E., Ruf, W., Spek, C.A., Reitsma, P.H., Bogdanov, V.Y., and Versteeg, H.H. (2009. ) Alternatively Spliced Tissue Factor Induces Angiogenesis through Integrin Ligation .Proceedings of the National Academy of Sciences of the United States of America, , Vol. 106, (No. 26 ) ,pp. 19496-19502

Eisenreich, Andreas; Bogdanov, Vladimir Y; Zakrzewicz, Andreas; Pries, Axel; Antoniak, Silvio; Poller, Wolfgang; Schultheiss, Heinz-Peter; Rauch, Ursula (2009. ) Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.Circulation research, , 104 (5 ) ,589-99

Tardos, J.G., Eisenreich, A., Deikus, G., Bechhofer, D.H., Chandradas, S., Zafar, U., Raugh U., and Bogdanov, V.Y. (2008. ) SR Proteins ASF/SF2 and SRp55 Participate in Tissue Factor Biosynthesis in Human Monocytic Cells .Journal of Thrombosis and Haemostasis, , Vol. 6, (No. 5 ) ,pp. 877-884

Szotowski, Björn; Antoniak, Silvio; Goldin-Lang, Petra; Tran, Quoc-Viet; Pels, Klaus; Rosenthal, Peter; Bogdanov, Vladimir Y; Borchert, Hans-Hubert; Schultheiss, Heinz-Peter; Rauch, Ursula (2007. ) Antioxidative treatment inhibits the release of thrombogenic tissue factor from irradiation- and cytokine-induced endothelial cells.Cardiovascular research, , 73 (4 ) ,806-12

Bogdanov, Vladimir Y (2006. ) Blood coagulation and alternative pre-mRNA splicing: an overview. Current molecular medicine, , 6 (8 ) ,859-69

Bogdanov, V.Y., Kirk, R.I., Miller, C., Hathcock, J.J., Vele, S., Gazdoiu, M., Nemerson, Y., and Taubman, M.B. (2006. ) Identification and Characterization of Murine Alternatively Spliced Tissue Factor .Journal of Thrombosis and Haemostasis, , Vol 4, (No. 1 ) ,pp. 158-167

Szotowski, Björn; Goldin-Lang, Petra; Antoniak, Silvio; Bogdanov, Vladimir Y; Pathirana, Delano; Pauschinger, Matthias; Dörner, Andrea; Kuehl, Uwe; Coupland, Sarah; Nemerson, Yale; Hummel, Michael; Poller, Wolfgang; Hetzer, Roland; Schultheiss, Heinz-Peter; Rauch, Ursula (2005. ) Alterations in myocardial tissue factor expression and cellular localization in dilated cardiomyopathy.Journal of the American College of Cardiology, , 45 (7 ) ,1081-9

Bogdanov VY, Hathcock JJ, Nemerson Y. (2004. ) Active Tissue Factor in Blood? Author reply. Nature Medicine, , Vol. 10, (No.11 ) ,p 1156

Bogdanov, Vladimir Y; Balasubramanian, Viji; Hathcock, James; Vele, Oana; Lieb, Mark; Nemerson, Yale (2003. ) Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein.Nature medicine, , 9 (4 ) ,458-62

Schecter, A.D., Spirn, B., Rossikhina, M., Giesen, P.L.A., Bogdanov, V.Y., Fallon, J.T., Fisher, E.A., Schnapp, L.M., Nemerson, Y., and Taubman, M.B. (2000. ) Release of Active Tissue Factor by Human Arterial Smooth Muscle Cells .Circulation Research, , Vol. 87 (No.3 ) ,pp. 126-132

Bogdanov, V.Y., Poon, M., and Taubman, M.B. (1998. ) Platelet-Derived Growth Factor-Specific Regulation of the JE Promoter in Rat Aortic Smooth Muscle Cells .The Journal of Biological Chemistry, , Vol. 273 (No. 38 ) ,pp. 24932-24938

Poon, M., Hsu, W.C., Bogdanov, V.Y., and Taubman, M.B. (1996. ) Secretion of Monocyte Chemotactic Activity by Cultured Rat Aortic Smooth Muscle Cells in Response to PDGF is Due Prodominantly to the Induction of JE/MCP-1. American Journal of Pathology, , Vol. 149, (No.1 ) ,pp. 307-317.

Taby, O., Rosenfield, C.-L., Bogdanov, V.Y., Nemerson, Y., and Taubman, M.B. (1996. ) Cloning of the Rat Tissue Factor cDNA and Promoter: Identification of a Serum-response Region .Thrombosis and Haemostasis, , Vol. 76, (No.5 ) ,pp. 697-702

Ramchandani, Divya; Unruh, Dusten; Lewis, Clayton S; Bogdanov, Vladimir Y; Weber, Georg F (2016. ) Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions.Laboratory investigation; a journal of technical methods and pathology, ,

Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y (2016. ) Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma.Oncotarget, , 7 (18 ) ,25264-75

Unruh, Dusten; Sagin, Farah; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Hart, Kimberly; Lindsell, Christopher J; Ahmad, Syed A; Bogdanov, Vladimir Y (2015. ) Levels of Alternatively Spliced Tissue Factor in the Plasma of Patients with Pancreatic Cancer May Help Predict Aggressive Tumor Phenotype.Annals of surgical oncology, , 22 Suppl 3 ,S1206-11

Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y (2015. ) Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis.Circulation, , 132 (20 ) ,1898-908

Bogdanov, Vladimir Y; Versteeg, Henri H (2015. ) "Soluble Tissue Factor" in the 21st Century: Definitions, Biochemistry, and Pathophysiological Role in Thrombus Formation.Seminars in thrombosis and hemostasis, , 41 (7 ) ,700-7

Manka, David; Chatterjee, Tapan K; Stoll, Lynn L; Basford, Joshua E; Konaniah, Eddy S; Srinivasan, Ramprasad; Bogdanov, Vladimir Y; Tang, Yaoliang; Blomkalns, Andra L; Hui, David Y; Weintraub, Neal L (2014. ) Transplanted perivascular adipose tissue accelerates injury-induced neointimal hyperplasia: role of monocyte chemoattractant protein-1.Arteriosclerosis, thrombosis, and vascular biology, , 34 (8 ) ,1723-30

Sluka, Susanna H M; Akhmedov, Alexander; Vogel, Johannes; Unruh, Dusten; Bogdanov, Vladimir Y; Camici, Giovanni G; Lüscher, Thomas F; Ruf, Wolfram; Tanner, Felix C (2014. ) Alternatively spliced tissue factor is not sufficient for embryonic development.PloS one, , 9 (5 ) ,e97793

Unruh, Dusten; Turner, Kevin; Srinivasan, Ramprasad; Kocatürk, Begüm; Qi, Xiaoyang; Chu, Zhengtao; Aronow, Bruce J; Plas, David R; Gallo, Catherine A; Kalthoff, Holger; Kirchhofer, Daniel; Ruf, Wolfram; Ahmad, Syed A; Lucas, Fred V; Versteeg, Henri H; Bogdanov, Vladimir Y (2014. ) Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.International journal of cancer, , 134 (1 ) ,9-20

Chatterjee, Tapan K; Aronow, Bruce J; Tong, Wilson S; Manka, David; Tang, Yaoliang; Bogdanov, Vladimir Y; Unruh, Dusten; Blomkalns, Andra L; Piegore, Mark G; Weintraub, Daniel S; Rudich, Steven M; Kuhel, David G; Hui, David Y; Weintraub, Neal L (2013. ) Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis.Physiological genomics, , 45 (16 ) ,697-709

Benson, Tyler W; Weintraub, Neal L; Kim, Ha Won; Seigler, Nichole; Kumar, Sanjiv; Pye, Jonathan; Horimatsu, Tetsuo; Pellenberg, Rod; Stepp, David W; Lucas, Rudolf; Bogdanov, Vladimir Y; Litwin, Sheldon E; Brittain, Julia E; Harris, Ryan A (2018. ) A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome.Laboratory investigation; a journal of technical methods and pathology, ,

Benson, Tyler W; Weintraub, Daniel S; Crowe, Matthew; Yiew, Nicole K H; Popoola, Orishebawo; Pillai, Ajay; Joseph, Joel; Archer, Krystal; Greenway, Charlotte; Chatterjee, Tapan K; Mintz, James; Stepp, David W; Stansfield, Brian K; Chen, Weiqin; Brittain, Julia; Bogdanov, Vladimir Y; Gao, Yan; Wilson, James G; Tang, Yaoliang; Kim, Ha Won; Weintraub, Neal L (2018. ) Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding.Molecular and cellular endocrinology, ,

Lewis, Clayton S; Bogdanov, Vladimir Y (2019. ) KLF11 (Krüppel-Like Factor 11) Modulates Arterial Thrombosis.Arteriosclerosis, thrombosis, and vascular biology, , 39 (3 ) ,309-310

Caversaccio, Nathalie I; Reina Caro, Maria D; Prince, Raja; Müller, Martin; Lewis, Clayton S; Bogdanov, Vladimir Y; Dufour, Jean-François; Angelillo-Scherrer, Anne (2018. ) Alternatively spliced tissue factor levels are elevated in the plasma of patients with chronic liver diseases.European journal of gastroenterology & hepatology, , 30 (12 ) ,1470-1475

Lewis C.S.;Elnakat Thomas H.;Orr-Asman M.A.;Green L.C.;Boody R.E.;Matiash K.;Karve A.;Hisada Y.M.;Davis H.W.;Qi X.;Mercer C.A.;Lucas F.V.;Aronow B.J.;Mackman N.;Versteeg H.H.;Bogdanov V.Y. (01-01-2019. ) mTOR kinase inhibition reduces tissue factor expression and growth of pancreatic neuroendocrine tumo.Journal of Thrombosis and Haemostasis, , 17 (1 ) ,169-182

Ünlü B.;Bogdanov V.;Versteeg H. (08-01-2017. ) Interplay between alternatively spliced Tissue Factor and full length Tissue Factor in modulating co.Thrombosis Research, , 156 ,1-7

Arderiu G.;Espinosa S.;Peña E.;Crespo J.;Aledo R.;Bogdanov V.;Badimon L. (08-01-2017. ) Tissue factor variants induce monocyte transformation and transdifferentiation into endothelial cell.Journal of Thrombosis and Haemostasis, , 15 (8 ) ,1689-1703

Sovershaev T.A.;Unruh D.;Sveinbjørnsson B.;Fallon J.T.;Hansen J.B.;Bogdanov V.Y.;Sovershaev M.A. (11-01-2016. ) A novel role of bone morphogenetic protein-7 in the regulation of adhesion and migration of human mo.Thrombosis Research, , 147 ,24-31

Østerud B.;Unruh D.;Olsen J.O.;Kirchhofer D.;Owens A.P.;Bogdanov V.Y. (09-01-2015. ) Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocyt.Journal of Thrombosis and Haemostasis, , 13 (9 ) ,1676-1682

Kocatürk B.;Tieken C.;Vreeken D.;Ünlü B.;Engels C.;de Kruijf E.;Kuppen P.;Reitsma P.;Bogdanov V.;Versteeg H. (09-01-2015. ) Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breas.Journal of Thrombosis and Haemostasis, , 13 (9 ) ,1683-1693

Sovershaev T.;Egorina E.;Unruh D.;Bogdanov V.;Hansen J.;Sovershaev M. (01-01-2015. ) BMP-7 induces TF expression in human monocytes by increasing F3 transcriptional activity.Thrombosis Research, , 135 (2 ) ,398-403

Davila M.;Robles-Carrillo L.;Unruh D.;Huo Q.;Gardiner C.;Sargent I.L.;Adam M.;Woodhams B.J.;Francis J.L.;Bogdanov V.Y.;Amirkhosravi A. (02-01-2014. ) Microparticle association and heterogeneity of tumor-derived tissue factor in plasma: Is it importan.Journal of Thrombosis and Haemostasis, , 12 (2 ) ,186-196

Yokota N.;Zarpellon A.;Chakrabarty S.;Bogdanov V.Y.;Gruber A.;Castellino F.J.;Mackman N.;Ellies L.G.;Weiler H.;Ruggeri Z.M.;Ruf W. (01-01-2014. ) Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice.Journal of Thrombosis and Haemostasis, , 12 (1 ) ,71-81

Chatterjee T.K.;Aronow B.J.;Tong W.S.;Manka D.;Tang Y.;Bogdanov V.Y.;Unruh D.;Blomkalns A.L.;Piegore M.G.;Weintraub D.S.;Rudich S.M.;Kuhel D.G.;Hui D.Y.;Weintraub N.L. (08-15-2013. ) Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular .Physiological Genomics, , 45 (16 ) ,697-709

Kocatürk B.;Van Den Berg Y.W.;Tieken C.;Mieog J.S.D.;De Kruijf E.M.;Engels C.C.;Van Der Ent M.A.;Kuppen P.J.;Van De Velde C.J.;Ruf W.;Reitsma P.H.;Osanto S.;Liefers G.J.;Bogdanov V.Y.;Versteeg H.H. (07-09-2013. ) Alternatively spliced tissue factor promotes breast cancer growth in a ?1 integrin-dependent manner.Proceedings of the National Academy of Sciences of the United States of America, , 110 (28 ) ,11517-11522

Srinivasan R.;Bogdanov V. (01-01-2012. ) Splice variants of Tissue Factor and integrin-mediated signaling.Thrombosis Research, , 129 (SUPPL. 2 ) ,

Basavaraj M.;Sovershaev M.;Egorina E.;Gruber F.;Bogdanov V.;Fallon J.;Asterud B.;Mathiesen E.;Hansen J. (01-01-2012. ) Circulating monocytes mirror the imbalance in TF and TFPI expression in carotid atherosclerotic plaq.Thrombosis Research, , 129 (4 ) ,

Srinivasan R.;Ozhegov E.;Van Den Berg Y.;Aronow B.;Franco R.;Palascak M.;Fallon J.;Ruf W.;Versteeg H.;Bogdanov V. (10-01-2011. ) Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the express.Journal of Thrombosis and Haemostasis, , 9 (10 ) ,2087-2096

Sovershaev M.;Egorina E.;Bogdanov V.;Seredkina N.;Fallon J.;Valkov A.;Østerud B.;Hansen J. (10-01-2010. ) Bone morphogenetic protein -7 increases thrombogenicity of lipid-rich atherosclerotic plaques via ac.Thrombosis Research, , 126 (4 ) ,306-310

Van Den Berg Y.;Van Den Hengel L.;Myers H.;Ayachi O.;Jordanova E.;Ruf W.;Spek C.;Reitsma P.;Bogdanov V.;Versteeg H. (11-17-2009. ) Alternatively spliced tissue factor induces angiogenesis through integrin ligation.Proceedings of the National Academy of Sciences of the United States of America, , 106 (46 ) ,19497-19502

van den Berg Y.;van den Hengel L.;Myers H.;Ayachi O.;Jordanova K.;Ruf W.;Spek A.;Reitsma P.;Bogdanov V.;Versteeg H. (08-05-2009. ) Erratum: (Journal of Thrombosis and Haemostasis)).Journal of Thrombosis and Haemostasis, , 7 (8 ) ,1436

Bogdanov V.;Cimmino G.;Tardos J.;Tunstead J.;Badimon J. (05-04-2009. ) Assessment of plasma tissue factor activity in patients presenting with coronary artery disease: Lim.Journal of Thrombosis and Haemostasis, , 7 (5 ) ,894-897

Tardos J.;Eisenreich A.;Deikus G.;Bechhofer D.;Chandradas S.;Zafar U.;Rauch U.;Bogdanov V. (05-01-2008. ) SR proteins ASF/SF2 and SRp55 participate in tissue factor biosynthesis in human monocytic cells.Journal of Thrombosis and Haemostasis, , 6 (5 ) ,877-884

Bogdanov V.Y.;Kirk R.I.;Miller C.;Hathcock J.J.;Velle S.;Gazdoiu M.;Nemerson Y.;Taubman M.B. (01-01-2006. ) Identification and characterization of murine alternatively spliced tissue factor.Journal of Thrombosis and Haemostasis, , 4 (1 ) ,158-167

Butenas S.;Mann K.;Bogdanov V.;Hathcock J.;Nemerson Y. (01-01-2004. ) Active tissue factor in blood? [2] (multiple letters).Nature Medicine, , 10 (11 ) ,1155-1156

Schecter A.;Spirn B.;Rossikhina M.;Giesen P.;Bogdanov V.;Fallon J.;Fisher E.;Schnapp L.;Nemerson Y.;Taubman M. (07-21-2000. ) Release of active tissue factor by human arterial smooth muscle cells.Circulation Research, , 87 (2 ) ,126-132

Bogdanov V.;Poon M.;Taubman M. (09-18-1998. ) Platelet-derived growth factor-specific regulation of the JE promoter in rat aortic smooth muscle ce.Journal of Biological Chemistry, , 273 (38 ) ,24932-24938

Taby O.;Rosenfield C.L.;Bogdanov V.;Nemerson Y.;Taubman M.B. (11-01-1996. ) Cloning of the rat tissue factor cDNA and promoter: Identification of a serum-response region .Thrombosis and Haemostasis, , 76 (5 ) ,697-702

Poon M.;Hsu W.;Bogdanov V.;Taubman M. (07-01-1996. ) Secretion of monocyte chemotactic activity by cultured rat aortic smooth muscle cells in response to .American Journal of Pathology, , 149 (1 ) ,307-317

N'Guessan, Kombo F; Davis, Harold W; Chu, Zhengtao; Vallabhapurapu, Subrahmanya D; Lewis, Clayton S; Franco, Robert S; Olowokure, Olugbenga; Ahmad, Syed A; Yeh, Jen Jen; Bogdanov, Vladimir Y; Qi, Xiaoyang (2020. ) Enhanced Efficacy of Combination of Gemcitabine and Phosphatidylserine-Targeted Nanovesicles against Pancreatic Cancer.Molecular therapy : the journal of the American Society of Gene Therapy, ,

Honors and Awards

1996 Young Investigator Award Eastern Hypertension Society, New York, NY

2005 Special Emphasis Research Career Development Award, NIDDK/NIH/DHHS

2006 Best Article Prize by Young Investigator Journal of Thrombosis and Haemostasis, ISTH Capacity: First author/prize recipient

2007 Select Faculty Honors and Awards, Dean's Report, Mount Sinai School of Medicine

2008 Best Article Prize by Young Investigator Journal of Thrombosis and Haemostasis, ISTH Capacity: Last author/mentor

Contact Information

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267-0508
Phone: 513-558-6276
Fax: 513-558-6703
vladimir.bogdanov@uc.edu