Raymond E. Boissy , PhD

Bachelor's Degree: University of Massachusetts 1976 (Zoology)

Master's Degree: University of Massachusetts 1979 (Veterinary & Animal Science)

Doctorate Degree: University of Massachusetts 1982 (Veterinary & Animal Science)

Post-Doc: Yale University School of Medicine 1985 (Dermatology/Cell Biology)

My current research objectives are to understand mechanisms of cellular differentiation and of gene product synthesis and translocation. I am using the pigment cell (melanocyte) of the skin and the eye as my model system. This cell embryonically originates from the neural crest and appears to undergo commitment to subpopulations prior to neural tube emigration. In the skin and the eye, the melanocyte specific gene product is melanin which is packaged into a cellular organelle, the melanosome.I am analyzing melanocyte aberrations which cause hypermelanosis and hypomelanosis in vitiligo and albinism respectively. These mutations affect the transcriptional, translational, and translocational events in the cells. In turn, normal cellular processes responsible for pigment cell function are addressed.

Grant: #NF050017 Investigators:RE Boissy 09-01-2005 -08-01-2006 Department of Defense On the Pathophysiology of Cutaneous Cafe-au-lait Lesions in Neurofibromatosis and the Role of Keratinocyte and/or Fibroblast-Synthesized Cytokines Role:Principal Investigator $100,000 Completed Type:Grant Level:National

Grant: #R21 AR056059 Investigators:RE Boissy 04-01-2008 -03-31-2010 National Institutes of Heatlh The composition and function of BLOC-2 in melanogenesis Role:Principal Investigator $275,000 Completed Type:Grant Level:National

Investigators:Boissy, Raymond 01-01-2003 -12-31-2003 National Vitiligo Foundation Investigation of Antioxidant Pathway Dysfunction in Vitiligo Etiology Role:PI $26,029.00 Closed Level:Private Non-Profit

Investigators:Boissy, Raymond 04-27-2004 -07-31-2005 National Institute of Arthritis, Musculoskeletal and Skin Disease 2004 National Vitiligo Foundation Scientific Conference Role:PI $20,000.00 Closed Level:Federal

Grant: #LAM-02-01-A0-S0-E0 Investigators:Boissy, Raymond 01-01-2000 -12-31-2000 Lymphangioleiomyomatosis Foundation (LAM) Characterization of LAM Cells for Melanocyte Specific Properties Role:PI $20,000.00 Closed Level:Private Non-Profit

Grant: #SWALM-01-01-A0-S0-E0 Investigators:Boissy, Raymond 12-27-1999 -12-27-2000 Swalm Foundation Studies on Melanocytes Cultured from Vitiligo Patients Role:PI $24,485.00 Closed Level:Private Non-Profit

Grant: #5-R01-AR-46115-03-A0-S0-E0 Investigators:Boissy, Raymond 08-01-2000 -07-31-2004 National Institute of Arthritis, Musculoskeletal and Skin Disease Phenols/Catechols in Occupational/Contact Vitiligo Skin Role:PI $765,101.00 Closed Level:Federal

Investigators:Boissy, Raymond 07-01-2001 -06-30-2002 Emerging Concepts, Inc. Novel Oligopeptides as Topical Skin Lightening Agents Role:PI $32,500.00 Closed Level:Industry

Grant: #NVF-14-01-A0-S0-E0 Investigators:Boissy, Raymond 01-01-2001 -12-31-2001 National Vitiligo Foundation Further Analysis of Apoptosis in Melanocytes Cultured from Vitiligo Patients Role:PI $12,000.00 Closed Level:Private Non-Profit

Grant: #NVF-13-01-A0-S0-E0 Investigators:Boissy, Raymond 01-01-1999 -07-31-2001 National Vitiligo Foundation Analysis of Tissue Derived from Patients with Vitiligo Role:PI $26,266.00 Closed Level:Private Non-Profit

Grant: #5-R01-AR-45429-04-A0-S0-E0 Investigators:Boissy, Raymond 08-01-1999 -07-31-2004 National Institute of Arthritis, Musculoskeletal and Skin Disease On the Role of the HPS Gene Product in Melanocytes Role:PI $826,054.00 Closed Level:Federal

Grant: #R01 ES009110 Investigators:Abdelmalek, Zalfa; Boissy, Raymond; Kadekaro, Ana Luisa; McGraw, Dennis 04-01-2008 -03-31-2014 National Institute of Environmental Health Sciences Signaling Pathways for UV-Induced Melanogenic Response Role:Collaborator $1,629,641.00 Active Level:Federal

Grant: #R21 AR056059 Investigators:Boissy, Raymond; Ip, Wallace; Smulian, Alan 05-01-2008 -04-30-2011 National Institute of Arthritis, Musculoskeletal and Skin Disease The Composition and Function of BLOC-2 in Melanogenesis Role:PI $367,176.00 Closed Level:Federal

Grant: #W81XWH-06-1-0172 Investigators:Boissy, Raymond 12-15-2005 -01-14-2007 Department of Defense On the Pathophysiology of Cutaneous Cafe-au-lait Lesions in Neurofibromatosis and the Role of Keratinocyte Synthesized Cytokines Role:PI $99,999.00 Closed Level:Federal

Grant: #SRS 007113 Investigators:Boissy, Raymond 07-01-2010 -06-30-2011 NeoStrata Company, Inc. Compound Testings for the Influence on Melanocyte Function Role:PI $26,894.00 Active Level:Industry

Grant: #Vitiligo9965 Investigators:Boissy, Raymond 03-01-2012 -02-28-2015 National Vitiligo Foundation On the Mechanism of Pitera as a Suppressor of Melanin Synthesis, Oxidative Stress and Inflammation Role:PI $120,000.00 Active Level:Private Non-Profit

Grant: #Vitiligo9966 Investigators:Boissy, Raymond 03-01-2012 -02-28-2015 National Vitiligo Foundation Pitera as a Potential Treatment for Hypopigmentary Lesions/Spots if the Skin Role:PI $195,000.00 Active Level:Private Non-Profit

Grant: #SRS 007950 Investigators:Boissy, Raymond 11-01-2011 -10-31-2012 NeoStrata Company, Inc. Analysis of Eight Compounds Ability to Influence Melanization for Neostrata -II Role:PI $38,333.33 Closed Level:Industry

Grant: #Dertmatology Foundation Research Career Development Award Investigators:Boissy, Raymond; Zhang, Yuhang 07-01-2012 -07-31-2012 Dermatology Foundation Contribution of Wnt in Epthelial-Mesenchymal Interactions for Hair Follicle Organogenesis Role:Collaborator $4,583.33 Closed Level:Private Non-Profit

Grant: #2013-2914 / AR063116 Investigators:Boissy, Raymond 03-01-2013 -02-28-2014 National Institute of Arthritis, Musculoskeletal and Skin Disease Autophagy - A Key Regulator of Melanosome Biogenesis in Human Cells Role:PI $50,686.00 Awarded Level:Federal

Grant: #SRA110505_Subaward #130045 Investigators:Boissy, Raymond 07-01-2014 -08-31-2017 Cincinnati Children's Hospital Medical Center P&G Contract - GALECTIN-3 Regulation Study Role:PI $60,000.00 Closed Level:Private Non-Profit

Peer Reviewed Publications

Ebanks, Jody P; Koshoffer, Amy; Wickett, R Randall; Schwemberger, Sandy; Babcock, George; Hakozaki, Tomohiro; Boissy, Raymond E (2011. ) Epidermal keratinocytes from light vs. dark skin exhibit differential degradation of melanosomes.The Journal of investigative dermatology, , 131 (6 ) ,1226-33 More Information

Boissy, R E; Nordlund, J J (2011. ) Vitiligo: current medical and scientific understanding. Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia, , 146 (1 ) ,69-75

Kadekaro, Ana Luisa; Leachman, Sancy; Kavanagh, Renny J; Swope, Viki; Cassidy, Pamela; Supp, Dorothy; Sartor, Maureen; Schwemberger, Sandy; Babcock, George; Wakamatsu, Kazumasa; Ito, Shosuke; Koshoffer, Amy; Boissy, Raymond E; Manga, Prashiela; Sturm, Richard A; Abdel-Malek, Zalfa A (2010. ) Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation.The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 24 (10 ) ,3850-60 More Information

Hariharan, Vidhya; Klarquist, Jared; Reust, Mary J; Koshoffer, Amy; McKee, Mark D; Boissy, Raymond E; Le Poole, I Caroline (2010. ) Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation.The Journal of investigative dermatology, , 130 (1 ) ,211-20 More Information

Klarquist, Jared; Barfuss, Allison; Kandala, Sridhar; Reust, Mary J; Braun, Ruedi K; Hu, Jennifer; Dilling, Daniel F; McKee, Mark D; Boissy, Raymond E; Love, Robert B; Nishimura, Michael I; Le Poole, I Caroline (2009. ) Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells.The American journal of pathology, , 175 (6 ) ,2463-72 More Information

Ebanks, Jody P; Wickett, R Randall; Boissy, Raymond E (2009. ) Mechanisms regulating skin pigmentation: the rise and fall of complexion coloration.International journal of molecular sciences, , 10 (9 ) ,4066-87 More Information

Boissy, Raymond E; Spritz, Richard A (2009. ) Frontiers and controversies in the pathobiology of vitiligo: separating the wheat from the chaff.Experimental dermatology, , 18 (7 ) ,583-5 More Information

Hachiya, Akira; Sriwiriyanont, Penkanok; Kobayashi, Takeshi; Nagasawa, Azumi; Yoshida, Hiroshi; Ohuchi, Atsushi; Kitahara, Takashi; Visscher, Marty O; Takema, Yoshinori; Tsuboi, Ryoji; Boissy, Raymond E (2009. ) Stem cell factor-KIT signalling plays a pivotal role in regulating pigmentation in mammalian hair.The Journal of pathology, , 218 (1 ) ,30-9 More Information

Hachiya, Akira; Sriwiriyanont, Penkanok; Fujimura, Tsutomu; Ohuchi, Atsushi; Kitahara, Takashi; Takema, Yoshinori; Kitzmiller, William J; Visscher, Marty O; Tsuboi, Ryoji; Boissy, Raymond E (2009. ) Mechanistic effects of long-term ultraviolet B irradiation induce epidermal and dermal changes in human skin xenografts.The American journal of pathology, , 174 (2 ) ,401-13 More Information

Chawla, S; deLong, M A; Visscher, M O; Wickett, R R; Manga, P; Boissy, R E (2008. ) Mechanism of tyrosinase inhibition by deoxyArbutin and its second-generation derivatives.The British journal of dermatology, , 159 (6 ) ,1267-74 More Information

Kasamatsu, Shinya; Hachiya, Akira; Higuchi, Kazuhiko; Ohuchi, Atsushi; Kitahara, Takashi; Boissy, Raymond E (2008. ) Production of the soluble form of KIT, s-KIT, abolishes stem cell factor-induced melanogenesis in human melanocytes.The Journal of investigative dermatology, , 128 (7 ) ,1763-72 More Information

Westbroek, Wendy; Adams, David; Huizing, Marjan; Koshoffer, Amy; Dorward, Heidi; Tinloy, Bradford; Parkes, Jennifer; Helip-Wooley, Amanda; Kleta, Robert; Tsilou, Ekaterina; Duvernay, Patrice; Digre, Kathleen B; Creel, Donnell J; White, James G; Boissy, Raymond E; Gahl, William A (2007. ) Cellular defects in Chediak-Higashi syndrome correlate with the molecular genotype and clinical phenotype.The Journal of investigative dermatology, , 127 (11 ) ,2674-7 More Information

Yoshida, Yasuko; Hachiya, Akira; Sriwiriyanont, Penkanok; Ohuchi, Atsushi; Kitahara, Takashi; Takema, Yoshinori; Visscher, Marty O; Boissy, Raymond E (2007. ) Functional analysis of keratinocytes in skin color using a human skin substitute model composed of cells derived from different skin pigmentation types.The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 21 (11 ) ,2829-39 More Information

Helip-Wooley, Amanda; Westbroek, Wendy; Dorward, Heidi M; Koshoffer, Amy; Huizing, Marjan; Boissy, Raymond E; Gahl, William A (2007. ) Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5.The Journal of investigative dermatology, , 127 (6 ) ,1471-8 More Information

Hachiya, A; Sriwiriyanont, P; Patel, A; Saito, N; Ohuchi, A; Kitahara, T; Takema, Y; Tsuboi, R; Boissy, R E; Visscher, M O; Wilson, J M; James, W M; Kobinger, G P (2007. ) Gene transfer in human skin with different pseudotyped HIV-based vectors.Gene therapy, , 14 (8 ) ,648-56 More Information

Manga, Prashiela; Sheyn, David; Yang, Fan; Sarangarajan, Rangaprasad; Boissy, Raymond E (2006. ) A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo.The American journal of pathology, , 169 (5 ) ,1652-62 More Information

Sriwiriyanont, Penkanok; Ohuchi, Atsushi; Hachiya, Akira; Visscher, Marty O; Boissy, Raymond E (2006. ) Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts.Laboratory investigation; a journal of technical methods and pathology, , 86 (11 ) ,1115-25 More Information

Li, Li; Hu, Dan-Ning; Zhao, Huiquan; McCormick, Steven A; Nordlund, James J; Boissy, Raymond E (2006. ) Uveal melanocytes do not respond to or express receptors for alpha-melanocyte-stimulating hormone.Investigative ophthalmology & visual science, , 47 (10 ) ,4507-12 More Information

Hamed, Saja H; Sriwiriyanont, Penkanok; deLong, Mitchell A; Visscher, Marty O; Wickett, R Randall; Boissy, Raymond E Comparative efficacy and safety of deoxyarbutin, a new tyrosinase-inhibiting agent. Journal of cosmetic science, , 57 (4 ) ,291-308

Wang, Runsheng; Tang, Phuong; Wang, Pei; Boissy, Raymond E; Zheng, Hui (2006. ) Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation.Proceedings of the National Academy of Sciences of the United States of America, , 103 (2 ) ,353-8 More Information

Smith, Justin W; Koshoffer, Amy; Morris, Randal E; Boissy, Raymond E (2005. ) Membranous complexes characteristic of melanocytes derived from patients with Hermansky-Pudlak syndrome type 1 are macroautophagosomal entities of the lysosomal compartment.Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 18 (6 ) ,417-26 More Information

Helip-Wooley, Amanda; Westbroek, Wendy; Dorward, Heidi; Mommaas, Mieke; Boissy, Raymond E; Gahl, William A; Huizing, Marjan (2005. ) Association of the Hermansky-Pudlak syndrome type-3 protein with clathrin.BMC cell biology, , 6 ,33 More Information

Boissy, Raymond E; Visscher, Marty; DeLong, Mitchell A (2005. ) DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency.Experimental dermatology, , 14 (8 ) ,601-8 More Information

Greatens, Amanda; Hakozaki, Tomohiro; Koshoffer, Amy; Epstein, Howard; Schwemberger, Sandy; Babcock, George; Bissett, Donald; Takiwaki, Hirotsugu; Arase, Seiji; Wickett, R Randall; Boissy, Raymond E (2005. ) Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible.Experimental dermatology, , 14 (7 ) ,498-508 More Information

Kroll, Tara M; Bommiasamy, Hemamalini; Boissy, Raymond E; Hernandez, Claudia; Nickoloff, Brian J; Mestril, Ruben; Caroline Le Poole, I (2005. ) 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo.The Journal of investigative dermatology, , 124 (4 ) ,798-806 More Information

Richmond, Bonnie; Huizing, Marjan; Knapp, Jill; Koshoffer, Amy; Zhao, Yang; Gahl, William A; Boissy, Raymond E (2005. ) Melanocytes derived from patients with Hermansky-Pudlak Syndrome types 1, 2, and 3 have distinct defects in cargo trafficking.The Journal of investigative dermatology, , 124 (2 ) ,420-7 More Information

Boissy, Raymond E; Richmond, Bonnie; Huizing, Marjan; Helip-Wooley, Amanda; Zhao, Yang; Koshoffer, Amy; Gahl, William A (2005. ) Melanocyte-specific proteins are aberrantly trafficked in melanocytes of Hermansky-Pudlak syndrome-type 3.The American journal of pathology, , 166 (1 ) ,231-40 More Information

Boissy, Raymond E; Manga, Prashiela (2004. ) On the etiology of contact/occupational vitiligo.Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 17 (3 ) ,208-14 More Information

Thong, H-Y; Jee, S-H; Sun, C-C; Boissy, R E (2003. ) The patterns of melanosome distribution in keratinocytes of human skin as one determining factor of skin colour. The British journal of dermatology, , 149 (3 ) ,498-505

Kitzmiller, W John; Stanton, Ryan A; Wickett, R Randall; Tolia, Gaurva; Boissy, Raymond E; Visscher, Marty O Noninvasive skin measurements after CO(2) and erbium laser resurfacing. Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery, , 23 (1 ) ,20-7

Boissy, Raymond E (2003. ) Melanosome transfer to and translocation in the keratinocyte. Experimental dermatology, , 12 Suppl 2 ,5-12

Huizing, Marjan; Boissy, Raymond E; Gahl, William A (2002. ) Hermansky-Pudlak syndrome: vesicle formation from yeast to man. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 15 (6 ) ,405-19

Rizvi, Tilat A; Huang, Yuan; Sidani, Amer; Atit, Radhika; Largaespada, David A; Boissy, Raymond E; Ratner, Nancy (2002. ) A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 22 (22 ) ,9831-40

Hakozaki, T; Minwalla, L; Zhuang, J; Chhoa, M; Matsubara, A; Miyamoto, K; Greatens, A; Hillebrand, G G; Bissett, D L; Boissy, R E (2002. ) The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. The British journal of dermatology, , 147 (1 ) ,20-31

Abdalkhani, Arman; Sellers, Rani; Gent, Justin; Wulitich, Heather; Childress, Sue; Stein, Barry; Boissy, Raymond E; Wysolmerski, John J; Foley, John (2002. ) Nipple connective tissue and its development: insights from the K14-PTHrP mouse. Mechanisms of development, , 115 (1-2 ) ,63-77

Le Poole, I C; Sarangarajan, R; Zhao, Y; Stennett, L S; Brown, T L; Sheth, P; Miki, T; Boissy, R E (2001. ) 'VIT1', a novel gene associated with vitiligo. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 14 (6 ) ,475-84

Sarangarajan, R; Boissy, R E (2001. ) Tyrp1 and oculocutaneous albinism type 3. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 14 (6 ) ,437-44

Sarangarajan, R; Budev, A; Zhao, Y; Gahl, W A; Boissy, R E (2001. ) Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak Syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA.The Journal of investigative dermatology, , 117 (3 ) ,641-6 More Information

Minwalla, L; Zhao, Y; Le Poole, I C; Wickett, R R; Boissy, R E (2001. ) Keratinocytes play a role in regulating distribution patterns of recipient melanosomes in vitro.The Journal of investigative dermatology, , 117 (2 ) ,341-7 More Information

Huizing, M; Sarangarajan, R; Strovel, E; Zhao, Y; Gahl, W A; Boissy, R E (2001. ) AP-3 mediates tyrosinase but not TRP-1 trafficking in human melanocytes. Molecular biology of the cell, , 12 (7 ) ,2075-85

Manga, P; Boissy, R E; Pifko-Hirst, S; Zhou, B K; Orlow, S J (2001. ) Mislocalization of melanosomal proteins in melanocytes from mice with oculocutaneous albinism type 2.Experimental eye research, , 72 (6 ) ,695-710 More Information

Minwalla, L; Zhao, Y; Cornelius, J; Babcock, G F; Wickett, R R; Le Poole, I C; Boissy, R E (2001. ) Inhibition of melanosome transfer from melanocytes to keratinocytes by lectins and neoglycoproteins in an in vitro model system. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 14 (3 ) ,185-94

Sarangarajan, R; Shumaker, H; Soleimani, M; Le Poole, C; Boissy, R E (2001. ) Molecular and functional characterization of sodium--hydrogen exchanger in skin as well as cultured keratinocytes and melanocytes. Biochimica et biophysica acta, , 1511 (1 ) ,181-92

Pickens, W L; Warner, R R; Boissy, Y L; Boissy, R E; Hoath, S B (2000. ) Characterization of vernix caseosa: water content, morphology, and elemental analysis.The Journal of investigative dermatology, , 115 (5 ) ,875-81 More Information

Sarangarajan, R; Zhao, Y; Babcock, G; Cornelius, J; Lamoreux, M L; Boissy, R E (2000. ) Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 13 (5 ) ,337-44

Le Poole, I C; Boissy, R E; Sarangarajan, R; Chen, J; Forristal, J J; Sheth, P; Westerhof, W; Babcock, G; Das, P K; Saelinger, C B (2000. ) PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum.In vitro cellular & developmental biology. Animal, , 36 (5 ) ,309-19 More Information

Yang, F; Sarangarajan, R; Le Poole, I C; Medrano, E E; Boissy, R E (2000. ) The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity.The Journal of investigative dermatology, , 114 (1 ) ,157-64 More Information

Yang, F; Abdel-Malek, Z; Boissy, R E Effects of commonly used mitogens on the cytotoxicity of 4-tertiary butylphenol to human melanocytes.In vitro cellular & developmental biology. Animal, , 35 (10 ) ,566-70 More Information

Le Poole, I C; Yang, F; Brown, T L; Cornelius, J; Babcock, G F; Das, P K; Boissy, R E (1999. ) Altered gene expression in melanocytes exposed to 4-tertiary butyl phenol (4-TBP): upregulation of the A2b adenosine receptor 1.The Journal of investigative dermatology, , 113 (5 ) ,725-31 More Information

Introne, W; Boissy, R E; Gahl, W A (1999. ) Clinical, molecular, and cell biological aspects of Chediak-Higashi syndrome.Molecular genetics and metabolism, , 68 (2 ) ,283-303 More Information

Yang, F; Boissy, R E (1999. ) Effects of 4-tertiary butylphenol on the tyrosinase activity in human melanocytes. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 12 (4 ) ,237-45

Tripathi, R K; Flanders, D J; Young, T L; Oetting, W S; Ramaiah, A; King, R A; Boissy, R E; Nordlund, J J (1999. ) Microphthalmia-associated transcription factor (MITF) locus lacks linkage to human vitiligo or osteopetrosis: an evaluation. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 12 (3 ) ,187-92

Wood, J M; Jimbow, K; Boissy, R E; Slominski, A; Plonka, P M; Slawinski, J; Wortsman, J; Tosk, J (1999. ) What's the use of generating melanin? .Experimental dermatology, , 8 (2 ) ,153-64

Boissy, R E; Zhao, Y; Gahl, W A (1998. ) Altered protein localization in melanocytes from Hermansky-Pudlak syndrome: support for the role of the HPS gene product in intracellular trafficking. Laboratory investigation; a journal of technical methods and pathology, , 78 (9 ) ,1037-48

Boissy, R E; Sakai, C; Zhao, H; Kobayashi, T; Hearing, V J (1998. ) Human tyrosinase related protein-1 (TRP-1) does not function as a DHICA oxidase activity in contrast to murine TRP-1. Experimental dermatology, , 7 (4 ) ,198-204

Collawn, S S; Boissy, R E; Vasconez, L O (1998. ) Skin ultrastructure after CO2 laser resurfacing. Plastic and reconstructive surgery, , 102 (2 ) ,509-15

Collawn, S S; Boissy, R E; Gamboa, M; Vasconez, L O (1998. ) Ultrastructural study of the skin after facial chemical peels and the effect of moisturization on wound healing. Plastic and reconstructive surgery, , 101 (5 ) ,1374-9; discussion 1

Carden, S M; Boissy, R E; Schoettker, P J; Good, W V (1998. ) Albinism: modern molecular diagnosis. The British journal of ophthalmology, , 82 (2 ) ,189-95

Cieszka, K; Hill, H Z; Xin, P; Azure, M; Hill, G J; Meyenhofer, M F; Boissy, R E; Mitchell, D L (1997. ) Survival of Cloudman mouse melanoma cells after irradiation by solar wavelengths of light. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 10 (4 ) ,193-200

Hill, H Z; Hill, G J; Cieszka, K; Plonka, P M; Mitchell, D L; Meyenhofer, M F; Xin, P; Boissy, R E (1997. ) Comparative action spectrum for ultraviolet light killing of mouse melanocytes from different genetic coat color backgrounds. Photochemistry and photobiology, , 65 (6 ) ,983-9

Le Poole, C; Boissy, R E (1997. ) Vitiligo. Seminars in cutaneous medicine and surgery, , 16 (1 ) ,3-14

Boissy, R E; Nordlund, J J Molecular basis of congenital hypopigmentary disorders in humans: a review. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 10 (1-2 ) ,12-24

Nagle, D L; Karim, M A; Woolf, E A; Holmgren, L; Bork, P; Misumi, D J; McGrail, S H; Dussault, B J; Perou, C M; Boissy, R E; Duyk, G M; Spritz, R A; Moore, K J (1996. ) Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome.Nature genetics, , 14 (3 ) ,307-11 More Information

Boissy, R E; Zhao, H; Oetting, W S; Austin, L M; Wildenberg, S C; Boissy, Y L; Zhao, Y; Sturm, R A; Hearing, V J; King, R A; Nordlund, J J (1996. ) Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3". American journal of human genetics, , 58 (6 ) ,1145-56

Donatien, P D; Diment, S L; Boissy, R E; Orlow, S J (1996. ) Melanosomal and lysosomal alterations in murine melanocytes following transfection with the v-rasHa oncogene.International journal of cancer. Journal international du cancer, , 66 (4 ) ,557-63 More Information

Zhao, H; Eling, D J; Medrano, E E; Boissy, R E (1996. ) Retroviral infection with human tyrosinase-related protein-1 (TRP-1) cDNA upregulates tyrosinase activity and melanin synthesis in a TRP-1-deficient melanoma cell line. The Journal of investigative dermatology, , 106 (4 ) ,744-52

Boissy, R E; Lamoreux, M L (1995. ) In vivo and in vitro morphological analysis of melanocytes homozygous for the misp allele at the murine microphthalmia locus. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 8 (6 ) ,294-301

Beermann, F; Orlow, S J; Boissy, R E; Schmidt, A; Boissy, Y L; Lamoreux, M L (1995. ) Misrouting of tyrosinase with a truncated cytoplasmic tail as a result of the murine platinum (cp) mutation. Experimental eye research, , 61 (5 ) ,599-607

Farooqui, J Z; Medrano, E E; Boissy, R E; Tigelaar, R E; Nordlund, J J (1995. ) Thy-1+ dendritic cells express truncated form of POMC mRNA. Experimental dermatology, , 4 (5 ) ,297-301

Austin, L M; Boissy, R E (1995. ) Mammalian tyrosinase-related protein-1 is recognized by autoantibodies from vitiliginous Smyth chickens. An avian model for human vitiligo. The American journal of pathology, , 146 (6 ) ,1529-41

Zhao, H; Boissy, R E (1994. ) Distinguishing between the catalytic potential and apparent expression of tyrosinase activities. The American journal of the medical sciences, , 308 (6 ) ,322-30

Zhao, H; Boissy, Y L; Abdel-Malek, Z; King, R A; Nordlund, J J; Boissy, R E (1994. ) On the analysis of the pathophysiology of Chediak-Higashi syndrome. Defects expressed by cultured melanocytes. Laboratory investigation; a journal of technical methods and pathology, , 71 (1 ) ,25-34

Zhao, H; Zhao, Y; Nordlund, J J; Boissy, R E (1994. ) Human TRP-1 has tyrosine hydroxylase but no dopa oxidase activity. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 7 (3 ) ,131-40

Orlow, S J; Zhou, B K; Boissy, R E; Pifko-Hirst, S (1993. ) Identification of a mammalian melanosomal matrix glycoprotein. The Journal of investigative dermatology, , 101 (2 ) ,141-4

Farooqui, J Z; Auclair, B W; Robb, E; Sarkisian, E; Cooper, C; Alexander, J W; Warden, G; Boissy, R E; Norlund, J (1993. ) Histological, biochemical, and ultrastructural studies on hyperpigmented human skin xenografts. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 6 (4 Pt 1 ) ,226-33

Boissy, R E; Boissy, Y L; Krakowsky, J M; Lamoreux, M L; Lingrel, J B; Nordlund, J J (1993. ) Ocular pathology in mice with a transgenic insertion at the microphthalmia locus. Journal of submicroscopic cytology and pathology, , 25 (3 ) ,319-32

Searle, E A; Austin, L M; Boissy, Y L; Zhao, H; Nordlund, J J; Boissy, R E (1993. ) Smyth chicken melanocyte autoantibodies: cross-species recognition, in vivo binding, and plasma membrane reactivity of the antiserum. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 6 (3 ) ,145-57

Medrano, E E; Farooqui, J Z; Boissy, R E; Boissy, Y L; Akadiri, B; Nordlund, J J (1993. ) Chronic growth stimulation of human adult melanocytes by inflammatory mediators in vitro: implications for nevus formation and initial steps in melanocyte oncogenesis. Proceedings of the National Academy of Sciences of the United States of America, , 90 (5 ) ,1790-4

Zhou, B K; Boissy, R E; Pifko-Hirst, S; Moran, D J; Orlow, S J (1993. ) Lysosome-associated membrane protein-1 (LAMP-1) is the melanocyte vesicular membrane glycoprotein band II. The Journal of investigative dermatology, , 100 (2 ) ,110-4

Orlow, S J; Boissy, R E; Moran, D J; Pifko-Hirst, S (1993. ) Subcellular distribution of tyrosinase and tyrosinase-related protein-1: implications for melanosomal biogenesis. The Journal of investigative dermatology, , 100 (1 ) ,55-64

Krakowsky, J M; Boissy, R E; Neumann, J C; Lingrel, J B (1993. ) A DNA insertional mutation results in microphthalmia in transgenic mice. Transgenic research, , 2 (1 ) ,14-20

Lamoreux, M L; Boissy, R E; Womack, J E; Nordlund, J J The vit gene maps to the mi (microphthalmia) locus of the laboratory mouse. The Journal of heredity, , 83 (6 ) ,435-9

Austin, L M; Boissy, R E; Jacobson, B S; Smyth, J R (1992. ) The detection of melanocyte autoantibodies in the Smyth chicken model for vitiligo. Clinical immunology and immunopathology, , 64 (2 ) ,112-20

Chetty, B V; Boissy, R E; Warden, G D; Nordlund, J J (1992. ) Basement membrane and fibroblast aberration in blisters at the donor, graft, and spontaneously healed sites in patients with burns. Archives of dermatology, , 128 (2 ) ,181-6

Boissy, R E; Liu, Y Y; Medrano, E E; Nordlund, J J (1991. ) Structural aberration of the rough endoplasmic reticulum and melanosome compartmentalization in long-term cultures of melanocytes from vitiligo patients. The Journal of investigative dermatology, , 97 (3 ) ,395-404

Boissy, R E; Beato, K E; Nordlund, J J (1991. ) Dilated rough endoplasmic reticulum and premature death in melanocytes cultured from the vitiligo mouse. The American journal of pathology, , 138 (6 ) ,1511-25

Orlow, S J; Chakraborty, A K; Boissy, R E; Pawelek, J M (1990. ) Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers. Experimental cell research, , 191 (2 ) ,209-18

Boissy, R E; Trinkle, L S; Nordlund, J J (1990. ) Neural-tube-derived melanocyte subsets undergo commitment to their distinct lineages in culture. Cell differentiation and development : the official journal of the International Society of Developmental Biologists, , 30 (2 ) ,129-45

Hoath, S B; Donnelly, M M; Boissy, R E (1990. ) Sensory transduction and the mammalian epidermis. Biosensors & bioelectronics, , 5 (5 ) ,351-66

Hoath, S B; Pickens, W L; Sells, S F; Boissy, R E (1990. ) Epidermal development in the growth retarded fetal rat. Journal of developmental physiology, , 13 (1 ) ,41-50

Boissy, R E; Trinkle, L S; Nordlund, J J (1989. ) Separation of pigmented and albino melanocytes and the concomitant evaluation of endogenous peroxide content using flow cytometry.Cytometry, , 10 (6 ) ,779-87 More Information

Nordlund, J J; Abdel-Malek, Z A; Boissy, R E; Rheins, L A (1989. ) Pigment cell biology: an historical review. The Journal of investigative dermatology, , 92 (4 Suppl ) ,53S-60S

Abdel-Malek, Z A; Swope, V B; Trinkle, L S; Ferroni, E N; Boissy, R E; Nordlund, J J (1988. ) Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2'-deoxyuridine method of DNA analysis.Journal of cellular physiology, , 136 (2 ) ,247-56 More Information

Boissy, R E (1988. ) The melanocyte. Its structure, function, and subpopulations in skin, eyes, and hair. Dermatologic clinics, , 6 (2 ) ,161-73

Boissy, R E; Gecks, S; Smyth, J R; Nordlund, J J (1988. ) Ocular pathology in the minimally depigmented subline of the vitiliginous Smyth chicken. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, , 1 (5 ) ,303-14

Boissy, R E; Lamoreux, M L (1988. ) Animal models of an acquired pigmentary disorder--vitiligo. Progress in clinical and biological research, , 256 ,207-18

Boissy, R E; Moellmann, G E; Lerner, A B (1987. ) Morphology of melanocytes in hair bulbs and eyes of vitiligo mice. The American journal of pathology, , 127 (2 ) ,380-8

Boissy, R E; Moellmann, G E; Halaban, R (1987. ) Tyrosinase and acid phosphatase activities in melanocytes from avian albinos. The Journal of investigative dermatology, , 88 (3 ) ,292-300

Lerner, A B; Shiohara, T; Boissy, R E; Jacobson, K A; Lamoreux, M L; Moellmann, G E (1986. ) A mouse model for vitiligo. The Journal of investigative dermatology, , 87 (3 ) ,299-304

Boissy, R E; Moellmann, G; Trainer, A T; Smyth, J R; Lerner, A B (1986. ) Delayed-amelanotic (DAM or Smyth) chicken: melanocyte dysfunction in vivo and in vitro. The Journal of investigative dermatology, , 86 (2 ) ,149-56

Boissy, R E; Halaban, R (1985. ) Establishment of proliferative, pure cultures of pigmented chicken melanocytes from neural tubes. The Journal of investigative dermatology, , 84 (2 ) ,158-61

Boissy, R E; Lamont, S J; Smyth, J R (1984. ) Persistence of abnormal melanocytes in immunosuppressed chickens of the autoimmune "DAM" line. Cell and tissue research, , 235 (3 ) ,663-8

Boissy, R E; Smyth, J R; Fite, K V (1983. ) Progressive cytologic changes during the development of delayed feather amelanosis and associated choroidal defects in the DAM chicken line. A vitiligo model. The American journal of pathology, , 111 (2 ) ,197-212

Lamont, S J; Boissy, R E; Smyth, J R (1982. ) Humoral immune response and expression of spontaneous postnatal amelanosis in DAM line chickens. Immunological communications, , 11 (2 ) ,121-7

Smyth, J R; Boissy, R E; Fite, K V; Albert, D M (1981. ) Retinal dystrophy associated with a postnatal amelanosis in the chicken. Investigative ophthalmology & visual science, , 20 (6 ) ,799-803

Smyth, J R; Boissy, R E; Fite, K V The DAM chicken: a model for spontaneous postnatal cutaneous and ocular amelanosis. The Journal of heredity, , 72 (3 ) ,150-6

Chalupa, Allison; Koshoffer, Amy; Galan, Emily; Yu, Lan; Liu, Fu-Tong; Boissy, Raymond E (2014. ) Melanocytic Galectin-3 is Associated with Tyrosinase Related Protein-1 and Pigment Biosynthesis.The Journal of investigative dermatology, , More Information

Yoshida, Hiroshi; Taguchi, Hiroyuki; Hachiya, Akira; Kitahara, Takashi; Boissy, Raymond E; Visscher, Marty O (2014. ) The natural trait of the curvature of human hair is correlated with bending of the hair follicle and hair bulb by a structural disparity in the root sheath.Journal of dermatological science, , More Information

Mosenson, Jeffrey A; Flood, Kelsey; Klarquist, Jared; Eby, Jonathan M; Koshoffer, Amy; Boissy, Raymond E; Overbeck, Andreas; Tung, Rebecca C; Le Poole, I Caroline (2014. ) Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress.Pigment cell & melanoma research, , 27 (2 ) ,209-20 More Information

Domyan, Eric T; Guernsey, Michael W; Kronenberg, Zev; Krishnan, Shreyas; Boissy, Raymond E; Vickrey, Anna I; Rodgers, Clifford; Cassidy, Pamela; Leachman, Sancy A; Fondon, John W; Yandell, Mark; Shapiro, Michael D (2014. ) Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.Current biology : CB, , 24 (4 ) ,459-64 More Information

Abu, Eme A; Su, Shengchang; Sallans, Larry; Boissy, Raymond E; Greatens, Amanda; Heineman, William R; Hassett, Daniel J (2013. ) Cyclic voltammetric, fluorescence and biological analysis of purified aeruginosin A, a secreted red pigment of Pseudomonas aeruginosa PAO1.Microbiology (Reading, England), , 159 (Pt 8 ) ,1736-47 More Information

Gilbert, Emily R; Eby, Jonathan M; Hammer, Adam M; Klarquist, Jared; Christensen, David G; Barfuss, Allison J; Boissy, Raymond E; Picken, Maria M; Love, Robert B; Dilling, Daniel F; Le Poole, I Caroline (2013. ) Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis.The American journal of pathology, , 183 (1 ) ,226-34 More Information

Lakhter, Alexander J; Kanginakudru, Sriramana; Warren, Simon; Touloukian, Christopher E; Boissy, Raymond E; Naidu, Samisubbu R (2013. ) Impaired PIASy-Tip60 signaling weakens activation of p53 in melanoma.Melanoma research, , 23 (3 ) ,213-7 More Information

Ebanks, Jody P; Koshoffer, Amy; Wickett, R Randall; Hakozaki, Tomohiro; Boissy, Raymond E (2013. ) Hydrolytic enzymes of the interfollicular epidermis differ in expression and correlate with the phenotypic difference observed between light and dark skin.The Journal of dermatology, , 40 (1 ) ,27-33 More Information

Hawkes, Jason E; Cassidy, Pamela B; Manga, Prashiela; Boissy, Raymond E; Goldgar, David; Cannon-Albright, Lisa; Florell, Scott R; Leachman, Sancy A (2013. ) Report of a novel OCA2 gene mutation and an investigation of OCA2 variants on melanoma risk in a familial melanoma pedigree.Journal of dermatological science, , 69 (1 ) ,30-7 More Information

Chawla, Smita; Kvalnes, Kalla; deLong, Mitchell A; Wickett, Randall; Manga, Prashiela; Boissy, Raymond E (2012. ) DeoxyArbutin and its derivatives inhibit tyrosinase activity and melanin synthesis without inducing reactive oxygen species or apoptosis. Journal of drugs in dermatology : JDD, , 11 (10 ) ,e28-34

Boissy, Raymond E; Dell'Anna, Maria Lucia; Picardo, Mauro On the pathophysiology of vitiligo: possible treatment options.Indian journal of dermatology, venereology and leprology, , 78 (1 ) ,24-9 More Information

1993 -2006 Ad-hoc Reviewer National Institutes of Health Status:Recipient Level:National

1992 -1999 American Editor Pigment Cell Research Status:Recipient Level:National

2002 Society of Cosmetic Chemists Literature Award Status:Recipient Level:Professional Org. Type:Recognition

2001 -2008 Secretary/Treasurer PanAmerican Society for Pigment Cell Research Status:Recipient Level:Professional Org.

2005 -To Present President/Chairman National Vitiligo Foundation Status:Recipient Level:Professional Org.

2009 American Skin Association Achievement Award American Skin Association Status:Recipient Level:National Type:Recognition

Biology,Science,Cell Biology,Cell,Cell Biology,Research,Cell Organelle and Substructure,Cell Organelle,Organelle,Cell Substructure,Substructure,Specialized Structure,Structure,Cellular Physiology,Physiology,Cell Differentiation,Differentiation,Cellular Regulation and Integration,Cellular Regulation,Regulation,Cellular Integration,Integration,Nervous System,Microscopic Anatomy,Anatomy,Musculoskeletal System,Muscoskeletal,Cancer,Autoimmunity,Immunity,Ocular Manifestation of Systemic Disease,Ocular Manifestation,Manifestation,Systemic Disease,Disease,Skin,Leukoderma,Albinism and Depigmentation Condition,Albinism,Depigmentation,Tissue Culture,Tissue,Culture,Vitiligo,Electron Microsopy,EM,Melanization,Immune Cytochemistry,Immune,Cytochemistry,Chemistry

Research - Medical Science Building
231 Albert Sabin Way, Room 7167
Cincinnati  Ohio, 45267
Phone: 513-558-6247
Fax: 513-558-0198
raymond.boissy@uc.edu