Samantha Brugmann, PhD

Bachelor's Degree: Tulane University 1998 (Cell and Molecular Biology)

Doctoral Degree: The George Washington University 2004 (Genetics)

Postdoctoral Research Fellowship: Stanford University 2010 (Chemical and Systems Biology)

Craniofacial Development

Peer Reviewed Publications

Workman, Michael J; Mahe, Maxime M; Trisno, Stephen; Poling, Holly M; Watson, Carey L; Sundaram, Nambirajan; Chang, Ching-Fang; Schiesser, Jacqueline; Aubert, Philippe; Stanley, Edouard G; Elefanty, Andrew G; Miyaoka, Yuichiro; Mandegar, Mohammad A; Conklin, Bruce R; Neunlist, Michel; Brugmann, Samantha A; Helmrath, Michael A; Wells, James M  (2016). Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nature medicineMore Information

Chang, Ching-Fang; Chang, Ya-Ting; Millington, Grethel; Brugmann, Samantha A  (2016). Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. PLoS genetics, 12 (11) , e1006351More Information

Chang, Ya-Ting; Chaturvedi, Praneet; Schock, Elizabeth N; Brugmann, Samantha A  (2016). Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid(2). Frontiers in physiology, 7, 468More Information

Schock, Elizabeth N; Chang, Ching-Fang; Youngworth, Ingrid A; Davey, Megan G; Delany, Mary E; Brugmann, Samantha A  (2016). Utilizing the chicken as an animal model for human craniofacial ciliopathies. Developmental biology, 415 (2) , 326-37More Information

Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I  (2016). Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling. Clinical cancer research : an official journal of the American Association for Cancer Research, 22 (8) , 2062-73More Information

Schock, Elizabeth N; Chang, Ching-Fang; Struve, Jaime N; Chang, Ya-Ting; Chang, Julie; Delany, Mary E; Brugmann, Samantha A  (2015). Using the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of oral-facial-digital syndrome. Disease models & mechanisms, 8 (8) , 855-66More Information

Saal, Howard M; Prows, Cynthia A; Guerreiro, Iris; Donlin, Milene; Knudson, Luke; Sund, Kristen L; Chang, Ching-Fang; Brugmann, Samantha A; Stottmann, Rolf W  (2015). A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia. Human molecular genetics, 24 (12) , 3399-409More Information

Chang, Ching-Fang; Schock, Elizabeth N; Attia, Aria C; Stottmann, Rolf W; Brugmann, Samantha A  (2015). The ciliary baton: orchestrating neural crest cell development. Current topics in developmental biology, 111, 97-134More Information

Chang, Ching-Fang; Schock, Elizabeth N; O'Hare, Elizabeth A; Dodgson, Jerry; Cheng, Hans H; Muir, William M; Edelmann, Richard E; Delany, Mary E; Brugmann, Samantha A  (2014). The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2. Development (Cambridge, England), 141 (15) , 3003-12More Information

Chang, Anne L S; Atzmon, Gil; Bergman, Aviv; Brugmann, Samantha; Atwood, Scott X; Chang, Howard Y; Barzilai, Nir  (2014). Identification of genes promoting skin youthfulness by genome-wide association study. The Journal of investigative dermatology, 134 (3) , 651-7More Information

Liu, Han; Lan, Yu; Xu, Jingyue; Chang, Ching-Fang; Brugmann, Samantha A; Jiang, Rulang  (2013). Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proceedings of the National Academy of Sciences of the United States of America, 110 (46) , 18555-60More Information

Brugmann, Samantha A; Wells, James M  (2013). Building additional complexity to in vitro-derived intestinal tissues. Stem cell research & therapy, 4 Suppl 1, S1More Information

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Prescott, Sara; Brugmann, Samantha A; Swigut, Tomek; Wysocka, Joanna  (2012). Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest. Cell stem cell, 11 (5) , 633-48More Information

Powder, Kara E; Ku, Yuan-Chieh; Brugmann, Samantha A; Veile, Rose A; Renaud, Nicole A; Helms, Jill A; Lovett, Michael  (2012). A cross-species analysis of microRNAs in the developing avian face. PloS one, 7 (4) , e35111More Information

Lenton, Kelly; James, Aaron W; Manu, Alina; Brugmann, Samantha A; Birker, Daniel; Nelson, Emily R; Leucht, Philipp; Helms, Jill A; Longaker, Michael T  (2011). Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis (New York, N.Y. : 2000), 49 (10) , 784-96More Information

Zaghloul, Norann A; Brugmann, Samantha A  (2011). The emerging face of primary cilia. Genesis (New York, N.Y. : 2000), 49 (4) , 231-46More Information

Levi, Benjamin; James, Aaron W; Nelson, Emily R; Brugmann, Samantha A; Sorkin, Michael; Manu, Alina; Longaker, Michael T  (2011). Role of Indian hedgehog signaling in palatal osteogenesis. Plastic and reconstructive surgery, 127 (3) , 1182-90More Information

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Swigut, Tomek; Brugmann, Samantha A; Flynn, Ryan A; Wysocka, Joanna  (2011). A unique chromatin signature uncovers early developmental enhancers in humans. Nature, 470 (7333) , 279-83More Information

Cordero, Dwight R; Brugmann, Samantha; Chu, Yvonne; Bajpai, Ruchi; Jame, Maryam; Helms, Jill A  (2011). Cranial neural crest cells on the move: their roles in craniofacial development. American journal of medical genetics. Part A, 155A (2) , 270-9More Information

Brugmann, Samantha A; Cordero, Dwight R; Helms, Jill A  (2010). Craniofacial ciliopathies: A new classification for craniofacial disorders. American journal of medical genetics. Part A, 152A (12) , 2995-3006More Information

Levi, Benjamin; Brugmann, Samantha; Longaker, Michael T  (2010). Discussion: Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells. The Journal of craniofacial surgery, 21 (5) , 1450-1More Information

Brugmann, Samantha A; Allen, Nancy C; James, Aaron W; Mekonnen, Zesemayat; Madan, Elena; Helms, Jill A  (2010). A primary cilia-dependent etiology for midline facial disorders. Human molecular genetics, 19 (8) , 1577-92More Information

James, Aaron W; Theologis, Alexander A; Brugmann, Samantha A; Xu, Yue; Carre, Antoine L; Leucht, Philipp; Hamilton, Katherine; Korach, Kenneth S; Longaker, Michael T  (2009). Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. PloS one, 4 (9) , e7120More Information

ten Berge, Derk; Brugmann, Samantha A; Helms, Jill A; Nusse, Roel  (2008). Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development (Cambridge, England), 135 (19) , 3247-57More Information

Anderson, Charles T; Castillo, Alesha B; Brugmann, Samantha A; Helms, Jill A; Jacobs, Christopher R; Stearns, Tim  (2008). Primary cilia: cellular sensors for the skeleton. Anatomical record (Hoboken, N.J. : 2007), 291 (9) , 1074-8More Information

Schlosser, Gerhard; Awtry, Tammy; Brugmann, Samantha A; Jensen, Eric D; Neilson, Karen; Ruan, Gui; Stammler, Angelika; Voelker, Doris; Yan, Bo; Zhang, Chi; Klymkowsky, Michael W; Moody, Sally A  (2008). Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion. Developmental biology, 320 (1) , 199-214More Information

Rinn, John L; Wang, Jordon K; Allen, Nancy; Brugmann, Samantha A; Mikels, Amanda J; Liu, Helen; Ridky, Todd W; Stadler, H Scott; Nusse, Roel; Helms, Jill A; Chang, Howard Y  (2008). A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes & development, 22 (3) , 303-7More Information

Brugmann, Samantha A; Goodnough, L Henry; Gregorieff, Alex; Leucht, Philipp; ten Berge, Derk; Fuerer, Christophe; Clevers, Hans; Nusse, Roel; Helms, Jill A  (2007). Wnt signaling mediates regional specification in the vertebrate face. Development (Cambridge, England), 134 (18) , 3283-95More Information

Goodnough, L Henry; Brugmann, Samantha A; Hu, Diane; Helms, Jill A  (2007). Stage-dependent craniofacial defects resulting from Sprouty2 overexpression. Developmental dynamics : an official publication of the American Association of Anatomists, 236 (7) , 1918-28More Information

Rinn, John L; Kertesz, Michael; Wang, Jordon K; Squazzo, Sharon L; Xu, Xiao; Brugmann, Samantha A; Goodnough, L Henry; Helms, Jill A; Farnham, Peggy J; Segal, Eran; Chang, Howard Y  (2007). Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell, 129 (7) , 1311-23More Information

Brugmann, Samantha A; Tapadia, Minal D; Helms, Jill A  (2006). The molecular origins of species-specific facial pattern. Current topics in developmental biology, 73, 1-42More Information

Brugmann, Samantha A; Moody, Sally A  (2005). Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs. Biology of the cell, 97 (5) , 303-19More Information

Brugmann, Samantha A; Pandur, Petra D; Kenyon, Kristy L; Pignoni, Francesca; Moody, Sally A  (2004). Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development (Cambridge, England), 131 (23) , 5871-81More Information

Elliott K.;Brugmann S.  (03-01-2019). Sending mixed signals: Cilia-dependent signaling during development and disease. Developmental Biology, 447 (1) , 28-41More Information

Metzler M.;Raja S.;Elliott K.;Friedl R.;Tran N.;Brugmann S.;Larsen M.;Sandell L.  (08-30-2018). Erratum: Correction: RDH10-mediated retinol metabolism and RAR?-mediated retinoic acid signaling are. Development (Cambridge, England), 145 (17) More Information

Metzler M.;Raja S.;Elliott K.;Friedl R.;Tran N.;Brugmann S.;Larsen M.;Sandell L.  (08-01-2018). RDH10-mediated retinol metabolism and RAR?-mediated retinoic acid signaling are required for submand. Development (Cambridge), 145 (15) More Information

Elliott K.H.;Millington G.;Brugmann S.A.  (06-01-2018). A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development. Developmental Dynamics, 247 (6) , 818-831More Information

Schock E.;Brugmann S.  (11-15-2017). Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-de. Developmental Biology, 431 (2) , 168-178More Information

Schock E.;Brugmann S.  (09-01-2017). Discovery, diagnosis, and etiology of craniofacial ciliopathies. Cold Spring Harbor Perspectives in Biology, 9 (9) More Information

Millington G.;Elliott K.;Chang Y.;Chang C.;Dlugosz A.;Brugmann S.  (04-15-2017). Cilia-dependent GLI processing in neural crest cells is required for tongue development. Developmental Biology, 424 (2) , 124-137More Information

Schock E.N.;Struve J.N.;Chang C.F.;Williams T.J.;Snedeker J.;Attia A.C.;Stottmann R.W.;Brugmann S.A.  (03-01-2017). A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS ONE, 12 (3) More Information

Snedeker J.;Schock E.N.;Struve J.N.;Chang C.F.;Cionni M.;Tran P.V.;Brugmann S.A.;Stottmann R.W.  (03-01-2017). Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development. PLoS ONE, 12 (3) More Information

Chang Y.;Chaturvedi P.;Schock E.;Brugmann S.  (10-17-2016). Understanding mechanisms of GLI-mediated transcription during craniofacial development and disease u. Frontiers in Physiology, 7 (OCT) More Information

Schock E.N.;Chang C.F.;Struve J.N.;Chang J.;Brugmann S.A.  (07-13-2015). Using the talpid ² as novel model for determining the cellular and molecular . Cilia (SUPPLEMENT 1) More Information

Chang C.F.;Schock E.N.;Billmire D.A.;Brugmann S.A.  (01-01-2015). Craniofacial Syndromes: Etiology, Impact and Treatment. Principles of Developmental Genetics: Second Edition, 653-676More Information

James A.;Brugmann S.;Carre A.;Jame M.;Longaker M.  (07-21-2010). Invited commentary: Discharge prevalence estimation, high altitude and microtia in Ecuadorian patien. Journal of Neonatal-Perinatal Medicine, 3 (2) , 85-86More Information

Brugmann S.A.;Powder K.E.;Young N.M.;Goodnough L.H.;Hahn S.M.;James A.W.;Helms J.A.;Lovett M.  (03-01-2010). Comparative gene expression analysis of avian embryonic facial structures reveals new candidates for. Human Molecular Genetics, 19 (5) , 920-930More Information

Helms J.;Brugmann S.  (09-01-2007). The origins of species-specific facial morphology: The proof is in the pigeon. Integrative and Comparative Biology, 47 (3) , 338-342More Information

Brugmann S.;Helms J.  (01-01-2007). Shaping up and shipping out: the role of cilia in growth and patterning. Journal of musculoskeletal & neuronal interactions, 7 (4) , 300

Brugmann S.;Kim J.;Helms J.  (12-01-2006). Looking different: Understanding diversity in facial form. American Journal of Medical Genetics, Part A, 140 (23) , 2521-2529More Information

Academic - Division of Pediatric Plastic Surgery MLC 7007
Cincinnati Children's Hospital Medical Center
Cincinnati  Ohio, 45229
Phone: 513-636-7678
samantha.brugmann@cchmc.org