Samantha Brugmann

Samantha Brugmann

Associate Professor - Aff

Medical Sciences Building


COM Pediatrics Dev. Biology -

Division of Pediatric Plastic Surgery MLC 7007
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio 45229


Bachelor's Degree, Tulane University 1998 (Cell and Molecular Biology)

Doctoral Degree, The George Washington University 2004 (Genetics)

Postdoctoral Research Fellowship, Stanford University 2010 (Chemical and Systems Biology)

Research and Practice Interests

Craniofacial Development


Peer Reviewed Publications

Workman, Michael J; Mahe, Maxime M; Trisno, Stephen; Poling, Holly M; Watson, Carey L; Sundaram, Nambirajan; Chang, Ching-Fang; Schiesser, Jacqueline; Aubert, Philippe; Stanley, Edouard G; Elefanty, Andrew G; Miyaoka, Yuichiro; Mandegar, Mohammad A; Conklin, Bruce R; Neunlist, Michel; Brugmann, Samantha A; Helmrath, Michael A; Wells, James M (2016. ) Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.Nature medicine, ,

Chang, Ching-Fang; Chang, Ya-Ting; Millington, Grethel; Brugmann, Samantha A (2016. ) Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.PLoS genetics, , 12 (11 ) ,e1006351

Chang, Ya-Ting; Chaturvedi, Praneet; Schock, Elizabeth N; Brugmann, Samantha A (2016. ) Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid(2).Frontiers in physiology, , 7 ,468

Schock, Elizabeth N; Chang, Ching-Fang; Youngworth, Ingrid A; Davey, Megan G; Delany, Mary E; Brugmann, Samantha A (2016. ) Utilizing the chicken as an animal model for human craniofacial ciliopathies.Developmental biology, , 415 (2 ) ,326-37

Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I (2016. ) Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Clinical cancer research : an official journal of the American Association for Cancer Research, , 22 (8 ) ,2062-73

Schock, Elizabeth N; Chang, Ching-Fang; Struve, Jaime N; Chang, Ya-Ting; Chang, Julie; Delany, Mary E; Brugmann, Samantha A (2015. ) Using the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of oral-facial-digital syndrome.Disease models & mechanisms, , 8 (8 ) ,855-66

Saal, Howard M; Prows, Cynthia A; Guerreiro, Iris; Donlin, Milene; Knudson, Luke; Sund, Kristen L; Chang, Ching-Fang; Brugmann, Samantha A; Stottmann, Rolf W (2015. ) A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.Human molecular genetics, , 24 (12 ) ,3399-409

Chang, Ching-Fang; Schock, Elizabeth N; Attia, Aria C; Stottmann, Rolf W; Brugmann, Samantha A (2015. ) The ciliary baton: orchestrating neural crest cell development.Current topics in developmental biology, , 111 ,97-134

Chang, Ching-Fang; Schock, Elizabeth N; O'Hare, Elizabeth A; Dodgson, Jerry; Cheng, Hans H; Muir, William M; Edelmann, Richard E; Delany, Mary E; Brugmann, Samantha A (2014. ) The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2.Development (Cambridge, England), , 141 (15 ) ,3003-12

Chang, Anne L S; Atzmon, Gil; Bergman, Aviv; Brugmann, Samantha; Atwood, Scott X; Chang, Howard Y; Barzilai, Nir (2014. ) Identification of genes promoting skin youthfulness by genome-wide association study.The Journal of investigative dermatology, , 134 (3 ) ,651-7

Liu, Han; Lan, Yu; Xu, Jingyue; Chang, Ching-Fang; Brugmann, Samantha A; Jiang, Rulang (2013. ) Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.Proceedings of the National Academy of Sciences of the United States of America, , 110 (46 ) ,18555-60

Brugmann, Samantha A; Wells, James M (2013. ) Building additional complexity to in vitro-derived intestinal tissues.Stem cell research & therapy, , 4 Suppl 1 ,S1

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Prescott, Sara; Brugmann, Samantha A; Swigut, Tomek; Wysocka, Joanna (2012. ) Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest.Cell stem cell, , 11 (5 ) ,633-48

Powder, Kara E; Ku, Yuan-Chieh; Brugmann, Samantha A; Veile, Rose A; Renaud, Nicole A; Helms, Jill A; Lovett, Michael (2012. ) A cross-species analysis of microRNAs in the developing avian face.PloS one, , 7 (4 ) ,e35111

Lenton, Kelly; James, Aaron W; Manu, Alina; Brugmann, Samantha A; Birker, Daniel; Nelson, Emily R; Leucht, Philipp; Helms, Jill A; Longaker, Michael T (2011. ) Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling.Genesis (New York, N.Y. : 2000), , 49 (10 ) ,784-96

Zaghloul, Norann A; Brugmann, Samantha A (2011. ) The emerging face of primary cilia.Genesis (New York, N.Y. : 2000), , 49 (4 ) ,231-46

Levi, Benjamin; James, Aaron W; Nelson, Emily R; Brugmann, Samantha A; Sorkin, Michael; Manu, Alina; Longaker, Michael T (2011. ) Role of Indian hedgehog signaling in palatal osteogenesis.Plastic and reconstructive surgery, , 127 (3 ) ,1182-90

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Swigut, Tomek; Brugmann, Samantha A; Flynn, Ryan A; Wysocka, Joanna (2011. ) A unique chromatin signature uncovers early developmental enhancers in humans.Nature, , 470 (7333 ) ,279-83

Cordero, Dwight R; Brugmann, Samantha; Chu, Yvonne; Bajpai, Ruchi; Jame, Maryam; Helms, Jill A (2011. ) Cranial neural crest cells on the move: their roles in craniofacial development.American journal of medical genetics. Part A, , 155A (2 ) ,270-9

Brugmann, Samantha A; Cordero, Dwight R; Helms, Jill A (2010. ) Craniofacial ciliopathies: A new classification for craniofacial disorders.American journal of medical genetics. Part A, , 152A (12 ) ,2995-3006

Levi, Benjamin; Brugmann, Samantha; Longaker, Michael T (2010. ) Discussion: Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells.The Journal of craniofacial surgery, , 21 (5 ) ,1450-1

Brugmann, Samantha A; Allen, Nancy C; James, Aaron W; Mekonnen, Zesemayat; Madan, Elena; Helms, Jill A (2010. ) A primary cilia-dependent etiology for midline facial disorders.Human molecular genetics, , 19 (8 ) ,1577-92

James, Aaron W; Theologis, Alexander A; Brugmann, Samantha A; Xu, Yue; Carre, Antoine L; Leucht, Philipp; Hamilton, Katherine; Korach, Kenneth S; Longaker, Michael T (2009. ) Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion.PloS one, , 4 (9 ) ,e7120

ten Berge, Derk; Brugmann, Samantha A; Helms, Jill A; Nusse, Roel (2008. ) Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development.Development (Cambridge, England), , 135 (19 ) ,3247-57

Anderson, Charles T; Castillo, Alesha B; Brugmann, Samantha A; Helms, Jill A; Jacobs, Christopher R; Stearns, Tim (2008. ) Primary cilia: cellular sensors for the skeleton.Anatomical record (Hoboken, N.J. : 2007), , 291 (9 ) ,1074-8

Schlosser, Gerhard; Awtry, Tammy; Brugmann, Samantha A; Jensen, Eric D; Neilson, Karen; Ruan, Gui; Stammler, Angelika; Voelker, Doris; Yan, Bo; Zhang, Chi; Klymkowsky, Michael W; Moody, Sally A (2008. ) Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion.Developmental biology, , 320 (1 ) ,199-214

Rinn, John L; Wang, Jordon K; Allen, Nancy; Brugmann, Samantha A; Mikels, Amanda J; Liu, Helen; Ridky, Todd W; Stadler, H Scott; Nusse, Roel; Helms, Jill A; Chang, Howard Y (2008. ) A dermal HOX transcriptional program regulates site-specific epidermal fate.Genes & development, , 22 (3 ) ,303-7

Brugmann, Samantha A; Goodnough, L Henry; Gregorieff, Alex; Leucht, Philipp; ten Berge, Derk; Fuerer, Christophe; Clevers, Hans; Nusse, Roel; Helms, Jill A (2007. ) Wnt signaling mediates regional specification in the vertebrate face.Development (Cambridge, England), , 134 (18 ) ,3283-95

Goodnough, L Henry; Brugmann, Samantha A; Hu, Diane; Helms, Jill A (2007. ) Stage-dependent craniofacial defects resulting from Sprouty2 overexpression.Developmental dynamics : an official publication of the American Association of Anatomists, , 236 (7 ) ,1918-28

Rinn, John L; Kertesz, Michael; Wang, Jordon K; Squazzo, Sharon L; Xu, Xiao; Brugmann, Samantha A; Goodnough, L Henry; Helms, Jill A; Farnham, Peggy J; Segal, Eran; Chang, Howard Y (2007. ) Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell, , 129 (7 ) ,1311-23

Brugmann, Samantha A; Tapadia, Minal D; Helms, Jill A (2006. ) The molecular origins of species-specific facial pattern.Current topics in developmental biology, , 73 ,1-42

Brugmann, Samantha A; Moody, Sally A (2005. ) Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs.Biology of the cell, , 97 (5 ) ,303-19

Brugmann, Samantha A; Pandur, Petra D; Kenyon, Kristy L; Pignoni, Francesca; Moody, Sally A (2004. ) Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor.Development (Cambridge, England), , 131 (23 ) ,5871-81

Elliott K.;Brugmann S. (03-01-2019. ) Sending mixed signals: Cilia-dependent signaling during development and disease.Developmental Biology, , 447 (1 ) ,28-41

Metzler M.;Raja S.;Elliott K.;Friedl R.;Tran N.;Brugmann S.;Larsen M.;Sandell L. (08-30-2018. ) Erratum: Correction: RDH10-mediated retinol metabolism and RAR?-mediated retinoic acid signaling are.Development (Cambridge, England), , 145 (17 ) ,

Metzler M.;Raja S.;Elliott K.;Friedl R.;Tran N.;Brugmann S.;Larsen M.;Sandell L. (08-01-2018. ) RDH10-mediated retinol metabolism and RAR?-mediated retinoic acid signaling are required for submand.Development (Cambridge), , 145 (15 ) ,

Elliott K.H.;Millington G.;Brugmann S.A. (06-01-2018. ) A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.Developmental Dynamics, , 247 (6 ) ,818-831

Schock E.;Brugmann S. (11-15-2017. ) Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-de.Developmental Biology, , 431 (2 ) ,168-178

Schock E.;Brugmann S. (09-01-2017. ) Discovery, diagnosis, and etiology of craniofacial ciliopathies.Cold Spring Harbor Perspectives in Biology, , 9 (9 ) ,

Millington G.;Elliott K.;Chang Y.;Chang C.;Dlugosz A.;Brugmann S. (04-15-2017. ) Cilia-dependent GLI processing in neural crest cells is required for tongue development.Developmental Biology, , 424 (2 ) ,124-137

Schock E.N.;Struve J.N.;Chang C.F.;Williams T.J.;Snedeker J.;Attia A.C.;Stottmann R.W.;Brugmann S.A. (03-01-2017. ) A tissue-specific role for intraflagellar transport genes during craniofacial development.PLoS ONE, , 12 (3 ) ,

Snedeker J.;Schock E.N.;Struve J.N.;Chang C.F.;Cionni M.;Tran P.V.;Brugmann S.A.;Stottmann R.W. (03-01-2017. ) Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development.PLoS ONE, , 12 (3 ) ,

Chang Y.;Chaturvedi P.;Schock E.;Brugmann S. (10-17-2016. ) Understanding mechanisms of GLI-mediated transcription during craniofacial development and disease u.Frontiers in Physiology, , 7 (OCT ) ,

Schock E.N.;Chang C.F.;Struve J.N.;Chang J.;Brugmann S.A. (07-13-2015. ) Using the talpid 2 as novel model for determining the cellular and molecular .Cilia, , (SUPPLEMENT 1 ) ,

Chang C.F.;Schock E.N.;Billmire D.A.;Brugmann S.A. (01-01-2015. ) Craniofacial Syndromes: Etiology, Impact and Treatment.Principles of Developmental Genetics: Second Edition, , 653-676

James A.;Brugmann S.;Carre A.;Jame M.;Longaker M. (07-21-2010. ) Invited commentary: Discharge prevalence estimation, high altitude and microtia in Ecuadorian patien.Journal of Neonatal-Perinatal Medicine, , 3 (2 ) ,85-86

Brugmann S.A.;Powder K.E.;Young N.M.;Goodnough L.H.;Hahn S.M.;James A.W.;Helms J.A.;Lovett M. (03-01-2010. ) Comparative gene expression analysis of avian embryonic facial structures reveals new candidates for.Human Molecular Genetics, , 19 (5 ) ,920-930

Helms J.;Brugmann S. (09-01-2007. ) The origins of species-specific facial morphology: The proof is in the pigeon.Integrative and Comparative Biology, , 47 (3 ) ,338-342

Brugmann S.;Helms J. (01-01-2007. ) Shaping up and shipping out: the role of cilia in growth and patterning. Journal of musculoskeletal & neuronal interactions, , 7 (4 ) ,300

Brugmann S.;Kim J.;Helms J. (12-01-2006. ) Looking different: Understanding diversity in facial form.American Journal of Medical Genetics, Part A, , 140 (23 ) ,2521-2529

Contact Information

Academic - Division of Pediatric Plastic Surgery MLC 7007
Cincinnati Children's Hospital Medical Center
CincinnatiĀ  Ohio, 45229
Phone: 513-636-7678