Samantha Brugmann , PhD

Bachelor's Degree: Tulane University 1998 (Cell and Molecular Biology)

Doctoral Degree: The George Washington University 2004 (Genetics)

Postdoctoral Research Fellowship: Stanford University 2010 (Chemical and Systems Biology)

Craniofacial Development

Peer Reviewed Publications

Workman, Michael J; Mahe, Maxime M; Trisno, Stephen; Poling, Holly M; Watson, Carey L; Sundaram, Nambirajan; Chang, Ching-Fang; Schiesser, Jacqueline; Aubert, Philippe; Stanley, Edouard G; Elefanty, Andrew G; Miyaoka, Yuichiro; Mandegar, Mohammad A; Conklin, Bruce R; Neunlist, Michel; Brugmann, Samantha A; Helmrath, Michael A; Wells, James M (2016. ) Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.Nature medicine, , More Information

Chang, Ching-Fang; Chang, Ya-Ting; Millington, Grethel; Brugmann, Samantha A (2016. ) Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.PLoS genetics, , 12 (11 ) ,e1006351 More Information

Chang, Ya-Ting; Chaturvedi, Praneet; Schock, Elizabeth N; Brugmann, Samantha A (2016. ) Understanding Mechanisms of GLI-Mediated Transcription during Craniofacial Development and Disease Using the Ciliopathic Mutant, talpid(2).Frontiers in physiology, , 7 ,468 More Information

Schock, Elizabeth N; Chang, Ching-Fang; Youngworth, Ingrid A; Davey, Megan G; Delany, Mary E; Brugmann, Samantha A (2016. ) Utilizing the chicken as an animal model for human craniofacial ciliopathies.Developmental biology, , 415 (2 ) ,326-37 More Information

Romick-Rosendale, Lindsey E; Hoskins, Elizabeth E; Privette Vinnedge, Lisa M; Foglesong, Grant D; Brusadelli, Marion G; Potter, S Steven; Komurov, Kakajan; Brugmann, Samantha A; Lambert, Paul F; Kimple, Randall J; Virts, Elizabeth L; Hanenberg, Helmut; Gillison, Maura L; Wells, Susanne I (2016. ) Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Clinical cancer research : an official journal of the American Association for Cancer Research, , 22 (8 ) ,2062-73 More Information

Schock, Elizabeth N; Chang, Ching-Fang; Struve, Jaime N; Chang, Ya-Ting; Chang, Julie; Delany, Mary E; Brugmann, Samantha A (2015. ) Using the avian mutant talpid2 as a disease model for understanding the oral-facial phenotypes of oral-facial-digital syndrome.Disease models & mechanisms, , 8 (8 ) ,855-66 More Information

Saal, Howard M; Prows, Cynthia A; Guerreiro, Iris; Donlin, Milene; Knudson, Luke; Sund, Kristen L; Chang, Ching-Fang; Brugmann, Samantha A; Stottmann, Rolf W (2015. ) A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia.Human molecular genetics, , 24 (12 ) ,3399-409 More Information

Chang, Ching-Fang; Schock, Elizabeth N; Attia, Aria C; Stottmann, Rolf W; Brugmann, Samantha A (2015. ) The ciliary baton: orchestrating neural crest cell development.Current topics in developmental biology, , 111 ,97-134 More Information

Chang, Ching-Fang; Schock, Elizabeth N; O'Hare, Elizabeth A; Dodgson, Jerry; Cheng, Hans H; Muir, William M; Edelmann, Richard E; Delany, Mary E; Brugmann, Samantha A (2014. ) The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2.Development (Cambridge, England), , 141 (15 ) ,3003-12 More Information

Chang, Anne L S; Atzmon, Gil; Bergman, Aviv; Brugmann, Samantha; Atwood, Scott X; Chang, Howard Y; Barzilai, Nir (2014. ) Identification of genes promoting skin youthfulness by genome-wide association study.The Journal of investigative dermatology, , 134 (3 ) ,651-7 More Information

Liu, Han; Lan, Yu; Xu, Jingyue; Chang, Ching-Fang; Brugmann, Samantha A; Jiang, Rulang (2013. ) Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.Proceedings of the National Academy of Sciences of the United States of America, , 110 (46 ) ,18555-60 More Information

Brugmann, Samantha A; Wells, James M (2013. ) Building additional complexity to in vitro-derived intestinal tissues.Stem cell research & therapy, , 4 Suppl 1 ,S1 More Information

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Prescott, Sara; Brugmann, Samantha A; Swigut, Tomek; Wysocka, Joanna (2012. ) Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest.Cell stem cell, , 11 (5 ) ,633-48 More Information

Powder, Kara E; Ku, Yuan-Chieh; Brugmann, Samantha A; Veile, Rose A; Renaud, Nicole A; Helms, Jill A; Lovett, Michael (2012. ) A cross-species analysis of microRNAs in the developing avian face.PloS one, , 7 (4 ) ,e35111 More Information

Lenton, Kelly; James, Aaron W; Manu, Alina; Brugmann, Samantha A; Birker, Daniel; Nelson, Emily R; Leucht, Philipp; Helms, Jill A; Longaker, Michael T (2011. ) Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling.Genesis (New York, N.Y. : 2000), , 49 (10 ) ,784-96 More Information

Zaghloul, Norann A; Brugmann, Samantha A (2011. ) The emerging face of primary cilia.Genesis (New York, N.Y. : 2000), , 49 (4 ) ,231-46 More Information

Levi, Benjamin; James, Aaron W; Nelson, Emily R; Brugmann, Samantha A; Sorkin, Michael; Manu, Alina; Longaker, Michael T (2011. ) Role of Indian hedgehog signaling in palatal osteogenesis.Plastic and reconstructive surgery, , 127 (3 ) ,1182-90 More Information

Rada-Iglesias, Alvaro; Bajpai, Ruchi; Swigut, Tomek; Brugmann, Samantha A; Flynn, Ryan A; Wysocka, Joanna (2011. ) A unique chromatin signature uncovers early developmental enhancers in humans.Nature, , 470 (7333 ) ,279-83 More Information

Cordero, Dwight R; Brugmann, Samantha; Chu, Yvonne; Bajpai, Ruchi; Jame, Maryam; Helms, Jill A (2011. ) Cranial neural crest cells on the move: their roles in craniofacial development.American journal of medical genetics. Part A, , 155A (2 ) ,270-9 More Information

Brugmann, Samantha A; Cordero, Dwight R; Helms, Jill A (2010. ) Craniofacial ciliopathies: A new classification for craniofacial disorders.American journal of medical genetics. Part A, , 152A (12 ) ,2995-3006 More Information

Levi, Benjamin; Brugmann, Samantha; Longaker, Michael T (2010. ) Discussion: Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells.The Journal of craniofacial surgery, , 21 (5 ) ,1450-1 More Information

Brugmann, Samantha A; Allen, Nancy C; James, Aaron W; Mekonnen, Zesemayat; Madan, Elena; Helms, Jill A (2010. ) A primary cilia-dependent etiology for midline facial disorders.Human molecular genetics, , 19 (8 ) ,1577-92 More Information

James, Aaron W; Theologis, Alexander A; Brugmann, Samantha A; Xu, Yue; Carre, Antoine L; Leucht, Philipp; Hamilton, Katherine; Korach, Kenneth S; Longaker, Michael T (2009. ) Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion.PloS one, , 4 (9 ) ,e7120 More Information

ten Berge, Derk; Brugmann, Samantha A; Helms, Jill A; Nusse, Roel (2008. ) Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development.Development (Cambridge, England), , 135 (19 ) ,3247-57 More Information

Anderson, Charles T; Castillo, Alesha B; Brugmann, Samantha A; Helms, Jill A; Jacobs, Christopher R; Stearns, Tim (2008. ) Primary cilia: cellular sensors for the skeleton.Anatomical record (Hoboken, N.J. : 2007), , 291 (9 ) ,1074-8 More Information

Schlosser, Gerhard; Awtry, Tammy; Brugmann, Samantha A; Jensen, Eric D; Neilson, Karen; Ruan, Gui; Stammler, Angelika; Voelker, Doris; Yan, Bo; Zhang, Chi; Klymkowsky, Michael W; Moody, Sally A (2008. ) Eya1 and Six1 promote neurogenesis in the cranial placodes in a SoxB1-dependent fashion.Developmental biology, , 320 (1 ) ,199-214 More Information

Rinn, John L; Wang, Jordon K; Allen, Nancy; Brugmann, Samantha A; Mikels, Amanda J; Liu, Helen; Ridky, Todd W; Stadler, H Scott; Nusse, Roel; Helms, Jill A; Chang, Howard Y (2008. ) A dermal HOX transcriptional program regulates site-specific epidermal fate.Genes & development, , 22 (3 ) ,303-7 More Information

Brugmann, Samantha A; Goodnough, L Henry; Gregorieff, Alex; Leucht, Philipp; ten Berge, Derk; Fuerer, Christophe; Clevers, Hans; Nusse, Roel; Helms, Jill A (2007. ) Wnt signaling mediates regional specification in the vertebrate face.Development (Cambridge, England), , 134 (18 ) ,3283-95 More Information

Goodnough, L Henry; Brugmann, Samantha A; Hu, Diane; Helms, Jill A (2007. ) Stage-dependent craniofacial defects resulting from Sprouty2 overexpression.Developmental dynamics : an official publication of the American Association of Anatomists, , 236 (7 ) ,1918-28 More Information

Rinn, John L; Kertesz, Michael; Wang, Jordon K; Squazzo, Sharon L; Xu, Xiao; Brugmann, Samantha A; Goodnough, L Henry; Helms, Jill A; Farnham, Peggy J; Segal, Eran; Chang, Howard Y (2007. ) Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.Cell, , 129 (7 ) ,1311-23 More Information

Brugmann, Samantha A; Tapadia, Minal D; Helms, Jill A (2006. ) The molecular origins of species-specific facial pattern.Current topics in developmental biology, , 73 ,1-42 More Information

Brugmann, Samantha A; Moody, Sally A (2005. ) Induction and specification of the vertebrate ectodermal placodes: precursors of the cranial sensory organs.Biology of the cell, , 97 (5 ) ,303-19 More Information

Brugmann, Samantha A; Pandur, Petra D; Kenyon, Kristy L; Pignoni, Francesca; Moody, Sally A (2004. ) Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor.Development (Cambridge, England), , 131 (23 ) ,5871-81 More Information

Elliott K.;Brugmann S. (03-01-2019. ) Sending mixed signals: Cilia-dependent signaling during development and disease.Developmental Biology, , 447 (1 ) ,28-41 More Information

Metzler M.;Raja S.;Elliott K.;Friedl R.;Tran N.;Brugmann S.;Larsen M.;Sandell L. (08-30-2018. ) Erratum: Correction: RDH10-mediated retinol metabolism and RAR?-mediated retinoic acid signaling are.Development (Cambridge, England), , 145 (17 ) , More Information

Metzler M.;Raja S.;Elliott K.;Friedl R.;Tran N.;Brugmann S.;Larsen M.;Sandell L. (08-01-2018. ) RDH10-mediated retinol metabolism and RAR?-mediated retinoic acid signaling are required for submand.Development (Cambridge), , 145 (15 ) , More Information

Elliott K.H.;Millington G.;Brugmann S.A. (06-01-2018. ) A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.Developmental Dynamics, , 247 (6 ) ,818-831 More Information

Schock E.;Brugmann S. (11-15-2017. ) Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-de.Developmental Biology, , 431 (2 ) ,168-178 More Information

Schock E.;Brugmann S. (09-01-2017. ) Discovery, diagnosis, and etiology of craniofacial ciliopathies.Cold Spring Harbor Perspectives in Biology, , 9 (9 ) , More Information

Millington G.;Elliott K.;Chang Y.;Chang C.;Dlugosz A.;Brugmann S. (04-15-2017. ) Cilia-dependent GLI processing in neural crest cells is required for tongue development.Developmental Biology, , 424 (2 ) ,124-137 More Information

Schock E.N.;Struve J.N.;Chang C.F.;Williams T.J.;Snedeker J.;Attia A.C.;Stottmann R.W.;Brugmann S.A. (03-01-2017. ) A tissue-specific role for intraflagellar transport genes during craniofacial development.PLoS ONE, , 12 (3 ) , More Information

Snedeker J.;Schock E.N.;Struve J.N.;Chang C.F.;Cionni M.;Tran P.V.;Brugmann S.A.;Stottmann R.W. (03-01-2017. ) Unique spatiotemporal requirements for intraflagellar transport genes during forebrain development.PLoS ONE, , 12 (3 ) , More Information

Chang Y.;Chaturvedi P.;Schock E.;Brugmann S. (10-17-2016. ) Understanding mechanisms of GLI-mediated transcription during craniofacial development and disease u.Frontiers in Physiology, , 7 (OCT ) , More Information

Schock E.N.;Chang C.F.;Struve J.N.;Chang J.;Brugmann S.A. (07-13-2015. ) Using the talpid ² as novel model for determining the cellular and molecular .Cilia, , (SUPPLEMENT 1 ) , More Information

Chang C.F.;Schock E.N.;Billmire D.A.;Brugmann S.A. (01-01-2015. ) Craniofacial Syndromes: Etiology, Impact and Treatment.Principles of Developmental Genetics: Second Edition, , 653-676 More Information

James A.;Brugmann S.;Carre A.;Jame M.;Longaker M. (07-21-2010. ) Invited commentary: Discharge prevalence estimation, high altitude and microtia in Ecuadorian patien.Journal of Neonatal-Perinatal Medicine, , 3 (2 ) ,85-86 More Information

Brugmann S.A.;Powder K.E.;Young N.M.;Goodnough L.H.;Hahn S.M.;James A.W.;Helms J.A.;Lovett M. (03-01-2010. ) Comparative gene expression analysis of avian embryonic facial structures reveals new candidates for.Human Molecular Genetics, , 19 (5 ) ,920-930 More Information

Helms J.;Brugmann S. (09-01-2007. ) The origins of species-specific facial morphology: The proof is in the pigeon.Integrative and Comparative Biology, , 47 (3 ) ,338-342 More Information

Brugmann S.;Helms J. (01-01-2007. ) Shaping up and shipping out: the role of cilia in growth and patterning. Journal of musculoskeletal & neuronal interactions, , 7 (4 ) ,300

Brugmann S.;Kim J.;Helms J. (12-01-2006. ) Looking different: Understanding diversity in facial form.American Journal of Medical Genetics, Part A, , 140 (23 ) ,2521-2529 More Information

Academic - Division of Pediatric Plastic Surgery MLC 7007
Cincinnati Children's Hospital Medical Center
Cincinnati  Ohio, 45229
Phone: 513-636-7678
samantha.brugmann@cchmc.org