Charles Caldwell

Charles C. Caldwell

Professor of Surgery; Director, Division of Research

Medical Sciences Building

G484

COM Surgery TSIRG Caldwell Lab - 0558

Medical Sciences Building
SRU Room G479
Cincinnati, Ohio 45267

Professional Summary

Professor
Director, Division of Reseach
Department of Surgery

Education

Bachelor's Degree, University of California - San Diego 1991 (Chemistry)

Doctoral Degree, San Diego State University 1998 (Biochemistry)

Postdoctoral Training, National Institutes of Health 2003 (Immunology)

Research and Practice Interests

Host Immune Response to Sepsis and Trauma Injury

Research Support

Grant: #NIH/NIGMS R01 GM72760-01 Investigators:Charles C. Caldwell, PhD 09-01-2005 -08-30-2010 NIH Role of HIF-1a in T Cells During Sepsis Role:PI $163,000 yearly Active Type:Grant

Grant: #8904 Investigators:Charles Caldwell PhD 01-01-2007 -12-31-2009 The Shriners Hospital for Children The Role of Adenosine A2a Receptor Following Thermal Injury Role:PI $162,000 yearly Active Type:Grant

Grant: #NIH/NIDDK 5R01DK56029-06-10 Investigators:Charles Caldwell PhD 09-01-2004 -08-30-2009 NIH Regulation of Hepatic Ischemia/Reperfusion Injury Role:Co-PI $250,000 yearly Active Type:Grant

Grant: #NIH/NICHD R01 HD36888 Competitive Renewal Investigators:Chares Caldwell PhD 09-01-2005 -06-30-2010 NIH The Hepatocyte Growth Factor-Like Protein Receptor Role:Co-PI Active Type:Grant

Grant: #1-R01-GM-072760 Investigators:Caldwell, Charles 09-01-2005 -08-31-2011 National Institute of General Medical Sciences Role of HIF-1a in T Cells During Sepsis Role:PI $1,212,544.00 Closed Level:Federal

Investigators:Caldwell, Charles 07-01-2004 -06-30-2005 Pfizer, Inc. The Role of HIF in Atherosclerosis Role:PI $50,000.00 Closed Level:Industry

Grant: #IIRA-GA9001TG Investigators:Caldwell, Charles; Hassett, Daniel; Solomkin, Joseph 08-08-2008 -06-30-2010 Pfizer, Inc. Induction of PVL Production in Neutrophil Phagosomes: Cell Protection By Bacterial Protein Synthesis Inhibition and Its Effect on Infectious Mortality Role:Collaborator $60,787.50 Active Level:Industry

Grant: #3 R01 GM072760-04S1 Investigators:Caldwell, Charles 08-13-2009 -08-31-2010 National Institute of General Medical Sciences Role of HIF-1a in T Cells During Sepsis Role:PI $9,613.00 Closed Level:Federal

Grant: #W81XWH-09-1-0625 Investigators:Caldwell, Charles; Lentsch, Alex 09-03-2009 -09-02-2012 Department of the Army Medical Research Acquisition Activity Effects of Different Fluid Resuscitation Strategies on Systemic Inflammation, Immunocompromise, Organ Dysfunction and Death Role:Collaborator $708,840.00 Closed Level:Federal

Grant: #FA8650-11-2-6B05 Task 5 Investigators:Branson, Richard; Caldwell, Charles; Johannigman, Jay; Lentsch, Alex; Pritts, Timothy 11-23-2010 -11-22-2012 Air Force Research Laboratory Determining the Oxygen Requirements Using an Oxygen Concentrator at Altitude Role:Collaborator $776,561.00 Active Level:Federal

Grant: #R01GM100913 Investigators:Caldwell, Charles 12-15-2012 -11-30-2016 National Institute of General Medical Sciences Neutrophil-derived Microparticle Generation and Immune Impact During Sepsis Role:PI $299,539.00 Active Level:Federal

Grant: #13-708B-B-00 / FA7014-10-2-0001 Investigators:Caldwell, Charles 03-15-2013 -12-31-2013 Department of the Air Force Determining How Hyperbaria Impacts the Immune Response to Crush Injury Role:PI $74,135.00 Active Level:Federal

Grant: #R01 GM107625 Investigators:Caldwell, Charles; Lentsch, Alex; Pritts, Timothy 02-01-2014 -12-31-2018 National Institute of General Medical Sciences Red blood cell microparticles and lung inflammation after hemorrhage and resuscit Role:Collaborator $313,038.00 Awarded Level:Federal

Grant: #FA8650-14-2-6B20 under Master FA8650-10-2-6140 Investigators:Caldwell, Charles; Lentsch, Alex; Pritts, Timothy 05-23-2014 -05-22-2015 Air Force Research Laboratory Effect of pRBC Cryopreservation on Development of the Storage Lesion and Inflammation Role:Collaborator $247,143.00 Active Level:Federal

Grant: #1 R01 GM112930 Investigators:Caldwell, Charles; Fan, Guochang 01-01-2015 -12-31-2018 National Institute of General Medical Sciences Duplex miR-223 and Exosomes in Sepsis Role:Collaborator $307,928.00 Awarded Level:Federal

Grant: #FA8650-16-2-6G03 (task under Master FA8650-15-2-6605) Investigators:Blakeman, Thomas; Caldwell, Charles; Goodman, Michael; Makley, Amy; Pritts, Timothy 02-22-2016 -02-21-2018 Air Force Research Laboratory A Randomized Controlled Trial for Early Identification and Prevention of Acute Lung Injury After Hemorrhage Role:Collaborator $349,000.00 Awarded Level:Federal

Grant: #FA8650-16-2-6G05 (Task under Master FA8650-15-2-6605) Investigators:Caldwell, Charles; Goodman, Michael; Lentsch, Alex; Makley, Amy; Pritts, Timothy; Robinson, Bryce 02-26-2016 -02-25-2019 Air Force Research Laboratory Effect of fluid resuscitation strategy during en route care on acute lung injury after hemorrhage and burn injury. Role:Collaborator $396,000.00 Awarded Level:Federal

Grant: #17-931D-01 / W81XWH-16-1-0150 Investigators:Caldwell, Charles 07-20-2016 -07-19-2020 Department of the Army Medical Research Acquisition Activity The Effect of Hypobaria on Muscle Inflammation and Regeneration after Injury and Hemorrhagic Shock Role:PI $76,632.00 Active Level:Federal

Grant: #R01GM124156 Investigators:Caldwell, Charles; Goodman, Michael; Gulbins, Erich 05-01-2018 -04-30-2023 National Institute of General Medical Sciences Role of acid sphingomyelinase in the modulation of coagulation after traumatic brain injury Role:Collaborator $303,842.00 Awarded Level:Federal

Grant: #R01-GM-132149 Investigators:Caldwell, Charles; Fan, Guochang 04-01-2019 -03-31-2023 National Institutes of Health Roles of Sectm1a in macrophages and cardiac function during sepsis Role:Collaborator $304,713.00 Awarded Level:Federal

Grant: #R01 GM107625-06A1 Investigators:Caldwell, Charles; Gulbins, Erich; Lentsch, Alex; Pritts, Timothy 02-01-2014 -03-31-2023 National Institutes of Health Red blood cell microparticles and lung inflammation after hemorrhage and resuscitation Role:Collaborator $352,825.00 Awarded Level:Federal

Grant: #VA IPA Caldwell Investigators:Caldwell, Charles 07-01-2019 -06-30-2020 Department of Veterans Affairs IPA for Charles Caldwell - VA Merit Award for Rajat Madan Role:PI $7,072.64 Awarded Level:Federal

Grant: #Shriners 85800-CIN-17 Investigators:Caldwell, Charles 01-01-2020 -12-31-2020 Shriners Hospitals for Children - Cincinnati Epoxyeicosatrienoic Acids: Therapeutic Potential in Skin Grafting and Burns Role:PI $17,380.00 Awarded Level:Private Non-Profit

Grant: #85219-CIN-17 Investigators:Caldwell, Charles; Gulbins, Erich; Nomellini, Vanessa 01-01-2020 -12-31-2022 Shriners Hospitals for Children - Cincinnati Ceramide regulatory role upon neutrophil chemotaxis after burn injury Role:PI $249,873.00 Active Level:Private Non-Profit

Grant: #Shriners 85000 Investigators:Caldwell, Charles; Dale, Elizabeth; Gulbins, Erich 01-01-2020 -12-31-2021 Shriners Hospitals for Children - Cincinnati Exploiting bioactive lipid properties to rescue burn-injured mice from lung infection Role:PI $.00 Active Level:Private Non-Profit

Grant: #R35GM138020 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-01-2020 -06-30-2025 National Institute of General Medical Sciences Utilizing Immune Phenotypes to Prevent Chronic Critical Illness Role:Collaborator $401,250.00 Awarded Level:Federal

Grant: #SUB00002421 / R01GM139046 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-05-2020 -06-30-2025 National Institute of General Medical Sciences Stratifying Patient Immune Endotypes in Sepsis (SPIES Study) Role:PI $159,799.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Midura, Emily F; Jernigan, Peter L; Kuethe, Joshua W; Friend, Lou Ann; Veile, Rosalie; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D (2015. ) Microparticles impact coagulation after traumatic brain injury.The Journal of surgical research, , 197 (1 ) ,25-31

Kuethe, Joshua W; Midura, Emily F; Rice, Teresa C; Caldwell, Charles C (2015. ) Peritoneal wash contents used to predict mortality in a murine sepsis model.The Journal of surgical research, ,

Wilson, Gregory C; Freeman, Christopher M; Kuethe, Joshua W; Quillin, Ralph C; Nojima, Hiroyuki; Schuster, Rebecca; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B (2015. ) CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice.American journal of physiology. Gastrointestinal and liver physiology, , 308 (8 ) ,G702-9

Siegl, Daniel; Midura, Emily F; Annecke, Thorsten; Conzen, Peter; Caldwell, Charles C; Tschoep, Johannes (2015. ) The effect of ghrelin upon the early immune response in lean and obese mice during sepsis.PloS one, , 10 (4 ) ,e0122211

Kuethe, Joshua W; Mintz-Cole, Rachael; Johnson, Bobby L; Midura, Emily F; Caldwell, Charles C; Schneider, Barbara St Pierre Assessing the immune status of critically ill trauma patients by flow cytometry.Nursing research, , 63 (6 ) ,426-34

Yang, Sung; Stepien, David; Hanseman, Dennis; Robinson, Bryce; Goodman, Michael D; Pritts, Timothy A; Caldwell, Charles C; Remick, Daniel G; Lentsch, Alex B (2014. ) Substance P mediates reduced pneumonia rates after traumatic brain injury.Critical care medicine, , 42 (9 ) ,2092-100

Kuethe, Joshua W; Prakash, Priya S; Midura, Emily F; Johnson, Bobby L; Kasten, Kevin R; Caldwell, Charles C (2014. ) Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis.The Journal of surgical research, , 191 (1 ) ,19-24

Siegl, Daniel; Annecke, Thorsten; Johnson, Bobby L; Schlag, Christian; Martignoni, Andre; Huber, Nadine; Conzen, Peter; Caldwell, Charles C; Tschöp, Johannes (2014. ) Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis.Anesthesiology, , 121 (1 ) ,98-114

Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang (2014. ) Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis.Biochimica et biophysica acta, , 1842 (5 ) ,701-11

Lehmann, Christian; Sharawi, Nivin; Al-Banna, Nadia; Corbett, Nathan; Kuethe, Joshua W; Caldwell, Charles C (2014. ) Novel approaches to the development of anti-sepsis drugs.Expert opinion on drug discovery, , 9 (5 ) ,523-31

Johnson, Bobby L; Iii, ; Kuethe, Josh W; Caldwell, Charles C (2014. ) Neutrophil derived microvesicles: emerging role of a key mediator to the immune response. Endocrine, metabolic & immune disorders drug targets, , 14 (3 ) ,210-7

Freeman, Christopher M; Quillin, Ralph C; Wilson, Gregory C; Nojima, Hiroyuki; Johnson, Bobby L; Sutton, Jeffrey M; Schuster, Rebecca M; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B (2014. ) Characterization of microparticles after hepatic ischemia-reperfusion injury.PloS one, , 9 (5 ) ,e97945

Johnson, Bobby L; Goetzman, Holly S; Prakash, Priya S; Caldwell, Charles C (2013. ) Mechanisms underlying mouse TNF-? stimulated neutrophil derived microparticle generation.Biochemical and biophysical research communications, , 437 (4 ) ,591-6

Van Sweringen, Heather L; Sakai, Nozomu; Quillin, Ralph C; Bailey, Jeff; Schuster, Rebecca; Blanchard, John; Goetzman, Holly; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B (2013. ) Roles of hepatocyte and myeloid CXC chemokine receptor-2 in liver recovery and regeneration after ischemia/reperfusion in mice.Hepatology (Baltimore, Md.), , 57 (1 ) ,331-8

Nowak, Jeffrey E; Harmon, Kelli; Caldwell, Charles C; Wong, Hector R (2012. ) Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, , 13 (5 ) ,e323-9

Unsinger, Jacqueline; Burnham, Carey-Ann D; McDonough, Jacquelyn; Morre, Michel; Prakash, Priya S; Caldwell, Charles C; Dunne, W Michael; Hotchkiss, Richard S (2012. ) Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.The Journal of infectious diseases, , 206 (4 ) ,606-16

Prakash, Priya S; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A; Robinson, Bryce R H (2012. ) Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response.The journal of trauma and acute care surgery, , 73 (2 ) ,401-6; discussion 40

Belizaire, Ritha M; Prakash, Priya S; Richter, Jillian R; Robinson, Bryce R; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A (2012. ) Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation.Journal of the American College of Surgeons, , 214 (4 ) ,648-55; discussion 6

Standage, Stephen W; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector R (2012. ) Reduced peroxisome proliferator-activated receptor ? expression is associated with decreased survival and increased tissue bacterial load in sepsis.Shock (Augusta, Ga.), , 37 (2 ) ,164-9

Caldwell, Charles C; Hotchkiss, Richard S (2011. ) The first step in utilizing immune-modulating therapies: immune status determination.Critical care (London, England), , 15 (1 ) ,108

Clarke, Callisia; Kuboki, Satoshi; Sakai, Nozomu; Kasten, Kevin R; Tevar, Amit D; Schuster, Rebecca; Blanchard, John; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B (2011. ) CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.Hepatology (Baltimore, Md.), , 53 (1 ) ,261-71

Tschöp, Johannes; Dattilo, Jonathan R; Prakash, Priya S; Kasten, Kevin R; Tschöp, Matthias H; Caldwell, Charles C (2010. ) The leptin system: a potential target for sepsis induced immune suppression. Endocrine, metabolic & immune disorders drug targets, , 10 (4 ) ,336-47

Kasten, Kevin R; Prakash, Priya S; Unsinger, Jacqueline; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Seitz, Aaron P; Mazuski, Cristina N; Zhou, Tony T; Morre, Michel; Hotchkiss, Richard S; Hildeman, David A; Caldwell, Charles C (2010. ) Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.Infection and immunity, , 78 (11 ) ,4714-22

Kasten, Kevin R; Tschöp, Johannes; Goetzman, Holly S; England, Lisa G; Dattilo, Jonathan R; Cave, Cindy M; Seitz, Aaron P; Hildeman, David A; Caldwell, Charles C (2010. ) T-cell activation differentially mediates the host response to sepsis.Shock (Augusta, Ga.), , 34 (4 ) ,377-83

Kasten, Kevin R; Tschöp, Johannes; Adediran, Samuel G; Hildeman, David A; Caldwell, Charles C (2010. ) T cells are potent early mediators of the host response to sepsis.Shock (Augusta, Ga.), , 34 (4 ) ,327-36

Adediran, Samuel G; Dauplaise, Derrick J; Kasten, Kevin R; Tschöp, Johannes; Dattilo, Jonathan; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Robinson, Chad T; Caldwell, Charles C (2010. ) Early infection during burn-induced inflammatory response results in increased mortality and p38-mediated neutrophil dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology, , 299 (3 ) ,R918-25

Kasten, Kevin Richard; Tschöp, Johannes; Tschöp, Matthias Hans; Caldwell, Charles Curtis (2010. ) The cannabinoid 2 receptor as a potential therapeutic target for sepsis. Endocrine, metabolic & immune disorders drug targets, , 10 (3 ) ,224-34

Tschöp, Johannes; Nogueiras, Ruben; Haas-Lockie, Sarah; Kasten, Kevin R; Castañeda, Tamara R; Huber, Nadine; Guanciale, Kelsey; Perez-Tilve, Diego; Habegger, Kirk; Ottaway, Nickki; Woods, Stephen C; Oldfield, Brian; Clarke, Iain; Chua, Streamson; Farooqi, I Sadaf; O'Rahilly, Stephen; Caldwell, Charles C; Tschöp, Matthias H (2010. ) CNS leptin action modulates immune response and survival in sepsis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (17 ) ,6036-47

Unsinger, Jacqueline; McGlynn, Margaret; Kasten, Kevin R; Hoekzema, Andrew S; Watanabe, Eizo; Muenzer, Jared T; McDonough, Jacquelyn S; Tschoep, Johannes; Ferguson, Thomas A; McDunn, Jonathan E; Morre, Michel; Hildeman, David A; Caldwell, Charles C; Hotchkiss, Richard S (2010. ) IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.Journal of immunology (Baltimore, Md. : 1950), , 184 (7 ) ,3768-79

Kasten, Kevin R; Muenzer, Jared T; Caldwell, Charles C (2010. ) Neutrophils are significant producers of IL-10 during sepsis.Biochemical and biophysical research communications, , 393 (1 ) ,28-31

Kasten, Kevin R; Goetzman, Holly S; Reid, Maria R; Rasper, Alison M; Adediran, Samuel G; Robinson, Chad T; Cave, Cindy M; Solomkin, Joseph S; Lentsch, Alex B; Johannigman, Jay A; Caldwell, Charles C (2010. ) Divergent adaptive and innate immunological responses are observed in humans following blunt trauma.BMC immunology, , 11 ,4

Caldwell, Charles C; Chen, Yi; Goetzmann, Holly S; Hao, Yonghua; Borchers, Michael T; Hassett, Daniel J; Young, Lisa R; Mavrodi, Dmitri; Thomashow, Linda; Lau, Gee W (2009. ) Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis.The American journal of pathology, , 175 (6 ) ,2473-88

Tschöp, Johannes; Kasten, Kevin R; Nogueiras, Ruben; Goetzman, Holly S; Cave, Cynthia M; England, Lisa G; Dattilo, Jonathan; Lentsch, Alex B; Tschöp, Matthias H; Caldwell, Charles C (2009. ) The cannabinoid receptor 2 is critical for the host response to sepsis.Journal of immunology (Baltimore, Md. : 1950), , 183 (1 ) ,499-505

Kuboki, Satoshi; Sakai, Nozomu; Tschöp, Johannes; Edwards, Michael J; Lentsch, Alex B; Caldwell, Charles C (2009. ) Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 296 (5 ) ,G1054-9

Hassett, Daniel J; Sutton, Mark D; Schurr, Michael J; Herr, Andrew B; Caldwell, Charles C; Matu, Joseph O (2009. ) Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways.Trends in microbiology, , 17 (3 ) ,130-8

Tschöp, Johannes; Martignoni, André; Reid, Maria D; Adediran, Samuel G; Gardner, Jason; Noel, Greg J; Ogle, Cora K; Neely, Alice N; Caldwell, Charles C (2009. ) Differential immunological phenotypes are exhibited after scald and flame burns.Shock (Augusta, Ga.), , 31 (2 ) ,157-63

Caldwell, Charles C; Lentsch, Alex B (2008. ) Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion.Gastroenterology, , 135 (5 ) ,1460-2

Caldwell, Charles C; Martignoni, Andre; Leonis, Mike A; Ondiveeran, Hari Kumar; Fox-Robichaud, Alison E; Waltz, Susan E (2008. ) Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis.Critical care medicine, , 36 (5 ) ,1585-93

Martignoni, André; Tschöp, Johannes; Goetzman, Holly S; Choi, Lisa G; Reid, Maria D; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C (2008. ) CD4-expressing cells are early mediators of the innate immune system during sepsis.Shock (Augusta, Ga.), , 29 (5 ) ,591-7

Tschöp, Johannes; Martignoni, André; Goetzman, Holly S; Choi, Lisa G; Wang, Quan; Noel, John G; Ogle, Cora K; Pritts, Timothy A; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C (2008. ) Gammadelta T cells mitigate the organ injury and mortality of sepsis.Journal of leukocyte biology, , 83 (3 ) ,581-8

Noel, John G; Osterburg, Andrew; Wang, Quan; Guo, Xialing; Byrum, Denise; Schwemberger, Sandy; Goetzman, Holly; Caldwell, Charles C; Ogle, Cora K (2007. ) Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments.Shock (Augusta, Ga.), , 28 (6 ) ,684-93

Thiel, Manfred; Caldwell, Charles C; Kreth, Simone; Kuboki, Satoshi; Chen, P; Smith, Patrick; Ohta, Akio; Lentsch, Alex B; Lukashev, Dmitry; Sitkovsky, Michail V (2007. ) Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.PloS one, , 2 (9 ) ,e853

Caldwell, Charles C; Tschoep, Johannes; Lentsch, Alex B (2007. ) Lymphocyte function during hepatic ischemia/reperfusion injury.Journal of leukocyte biology, , 82 (3 ) ,457-64

Huang, Julie H; Cárdenas-Navia, L Isabel; Caldwell, Charles C; Plumb, Troy J; Radu, Caius G; Rocha, Paulo N; Wilder, Tuere; Bromberg, Jonathan S; Cronstein, Bruce N; Sitkovsky, Michail; Dewhirst, Mark W; Dustin, Michael L (2007. ) Requirements for T lymphocyte migration in explanted lymph nodes. Journal of immunology (Baltimore, Md. : 1950), , 178 (12 ) ,7747-55

Wetzel, Cynthia C; Leonis, Mike A; Dent, Arlene; Olson, Meredith A; Longmeier, Angela M; Ney, Paul A; Boivin, Greg P; Kader, Sarah A; Caldwell, Charles C; Degen, Sandra J F; Waltz, Susan E (2007. ) Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 292 (1 ) ,G253-61

Caldwell, Charles C; Okaya, Tomohisa; Martignoni, Andre; Husted, Thomas; Schuster, Rebecca; Lentsch, Alex B (2005. ) Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion.American journal of physiology. Gastrointestinal and liver physiology, , 289 (5 ) ,G969-76

Okaya, Tomohisa; Blanchard, John; Schuster, Rebecca; Kuboki, Satoshi; Husted, Thomas; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector; Solomkin, Joseph S; Lentsch, Alex B (2005. ) Age-dependent responses to hepatic ischemia/reperfusion injury. Shock (Augusta, Ga.), , 24 (5 ) ,421-7

Noel, John G; Guo, Xialing; Wells-Byrum, Denise; Schwemberger, Sandy; Caldwell, Charles C; Ogle, Cora K (2005. ) Effect of thermal injury on splenic myelopoiesis. Shock (Augusta, Ga.), , 23 (2 ) ,115-22

Olah, Mark E; Caldwell, Charles C (2003. ) Adenosine receptors and mammalian toll-like receptors: synergism in macrophages.Molecular interventions, , 3 (7 ) ,370-4

Lukashev, Dmitriy E; Smith, Patrick T; Caldwell, Charles C; Ohta, Akio; Apasov, Sergey G; Sitkovsky, Michail V (2003. ) Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs. Biochemical pharmacology, , 65 (12 ) ,2081-90

Thiel, Manfred; Caldwell, Charles C; Sitkovsky, Michail V (2003. ) The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases. Microbes and infection / Institut Pasteur, , 5 (6 ) ,515-26

Wen, Long T; Caldwell, Charles C; Knowles, Aileen F (2003. ) Poly(ADP-ribose) polymerase activation and changes in Bax protein expression associated with extracellular ATP-mediated apoptosis in human embryonic kidney 293-P2X7 cells. Molecular pharmacology, , 63 (3 ) ,706-13

Lukashev, Dmitriy E; Caldwell, Charles C; Chen, Pearl; Apasov, Sergey G; Margulies, David H; Sitkovsky, Michail V (2003. ) A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.Journal of receptor and signal transduction research, , 23 (1 ) ,33-52

Kojima, Hidefumi; Gu, Hua; Nomura, Saeko; Caldwell, Charles C; Kobata, Tetsuji; Carmeliet, Peter; Semenza, Gregg L; Sitkovsky, Michail V (2002. ) Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.Proceedings of the National Academy of Sciences of the United States of America, , 99 (4 ) ,2170-4

Caldwell, C C; Kojima, H; Lukashev, D; Armstrong, J; Farber, M; Apasov, S G; Sitkovsky, M V (2001. ) Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. Journal of immunology (Baltimore, Md. : 1950), , 167 (11 ) ,6140-9

Caldwell, C C; Hornyak, S C; Pendleton, E; Campbell, D; Knowles, A F (2001. ) Regulation of chicken gizzard ecto-ATPase activity by modulators that affect its oligomerization status.Archives of biochemistry and biophysics, , 387 (1 ) ,107-16

Zhou, P; Freidag, B L; Caldwell, C C; Seder, R A (2001. ) Perforin is required for primary immunity to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), , 166 (3 ) ,1968-74

Redegeld, F A; Caldwell, C C; Sitkovsky, M V (1999. ) Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation? .Trends in pharmacological sciences, , 20 (11 ) ,453-9

Caldwell, C C; Davis, M D; Knowles, A F (1999. ) Ectonucleotidases of avian gizzard smooth muscle and liver plasma membranes: a comparative study.Archives of biochemistry and biophysics, , 362 (1 ) ,46-58

Hurt, R D; Dale, L C; Fredrickson, P A; Caldwell, C C; Lee, G A; Offord, K P; Lauger, G G; Mar?si?, Z; Neese, L W; Lundberg, T G (1994. ) Nicotine patch therapy for smoking cessation combined with physician advice and nurse follow-up. One-year outcome and percentage of nicotine replacement. JAMA, , 271 (8 ) ,595-600

Myers, T F; Patrinos, M E; Muraskas, J; Caldwell, C C; Lambert, G H; Anderson, C L (1987. ) Dynamic trend monitoring of cerebral blood flow velocity in newborn infants. The Journal of pediatrics, , 110 (4 ) ,611-6

Caldwell, C C; Hurley, R M; Anderson, C L; Ahmed, G S; Myers, T F (1985. ) Nonimmune hydrops fetalis managed with peritoneal dialysis.American journal of perinatology, , 2 (3 ) ,211-3

Caldwell, C C; Stankiewicz, J; Anderson, C L; Ahmed, G S; Myers, T F (1985. ) Intubation-related tracheal stenosis in very-low-birth-weight infants. Diagnosis and treatment. American journal of diseases of children (1960), , 139 (6 ) ,618-20

Puczynski, M S; Dvonch, V M; Menendez, C E; Caldwell, C C (1984. ) Osteomyelitis of the great toe secondary to phlebotomy. Clinical orthopaedics and related research, , (190 ) ,239-40

Anderson, C L; Collin, M F; O'Keefe, J P; Challapalli, M; Myers, T F; Caldwell, C C; Ahmed, G S (1984. ) A widespread epidemic of mild necrotizing enterocolitis of unknown cause. American journal of diseases of children (1960), , 138 (10 ) ,979-83

Caldwell, C C; Levkoff, A H; Purohit, D M (1977. ) Paroxysmal supraventricular tachycardia in a neonate: a complication of racemic epinephrine inhalation for post-extubation stridor. Clinical pediatrics, , 16 (6 ) ,579-80

Purohit, D M; Caldwell, C C; Webb, H N; Levkoff, A H (1976. ) Effects of assisted ventilation on echocardiographic findings in two infants with patent ductus arteriosus. The Journal of thoracic and cardiovascular surgery, , 72 (2 ) ,294-5

Rice, Teresa C; Seitz, Aaron P; Edwards, Michael J; Gulbins, Erich; Caldwell, Charles C (2016. ) Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection.Journal of leukocyte biology, ,

Kuethe, Joshua W; Armocida, Stephanie M; Midura, Emily F; Rice, Teresa C; Hildeman, David A; Healy, Daniel P; Caldwell, Charles C (2016. ) Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury.Shock (Augusta, Ga.), , 45 (6 ) ,647-52

Johnson, Bobby L; Rice, Teresa C; Xia, Brent T; Boone, Kirsten I; Green, Ellis A; Gulbins, Erich; Caldwell, Charles C (2016. ) Amitriptyline Usage Exacerbates the Immune Suppression Following Burn Injury.Shock (Augusta, Ga.), ,

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2016. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, ,

Midura, Emily F; Prakash, Priya S; Johnson, Bobby L; Rice, Teresa C; Kunz, Natalia; Caldwell, Charles C (2016. ) Impact of caspase-8 and PKA in regulating neutrophil-derived microparticle generation.Biochemical and biophysical research communications, , 469 (4 ) ,917-22

Hoehn, Richard S; Jernigan, Peter L; Chang, Alex L; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Pritts, Timothy A (2016. ) Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 39 (1 ) ,331-40

Midura, Emily F; Kuethe, Joshua W; Rice, Teresa C; Veile, Rosalie; England, Lisa G; Friend, Lou Ann; Caldwell, Charles C; Goodman, Michael D (2016. ) Impact of Platelets and Platelet-Derived Microparticles on Hypercoagulability Following Burn Injury.Shock (Augusta, Ga.), , 45 (1 ) ,82-7

Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang (2015. ) Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.Scientific reports, , 5 ,13721

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. (03-01-2020. ) Fibrotic liver has prompt recovery after ischemia-reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 318 (3 ) ,G390-G400

Kim Y.;Goodman M.;Jung A.;Abplanalp W.;Schuster R.;Caldwell C.;Lentsch A.;Pritts T. (01-01-2020. ) Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via.Thrombosis Research, , 185 ,160-166

Hefele F.;Ditsch A.;Krysiak N.;Caldwell C.;Biberthaler P.;van Griensven M.;Huber-Wagner S.;Hanschen M. (10-11-2019. ) Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Plate.Frontiers in Immunology, , 10 ,

Seitz A.P.;Schumacher F.;Baker J.;Soddemann M.;Wilker B.;Caldwell C.C.;Gobble R.M.;Kamler M.;Becker K.A.;Beck S.;Kleuser B.;Edwards M.J.;Gulbins E. (08-01-2019. ) Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia.Journal of Molecular Medicine, , 97 (8 ) ,1195-1211

Crouser E.;Caldwell C.;Hotchkiss R. (05-01-2019. ) What Is the Skinny on Obesity during Sepsis?.Critical Care Medicine, , 47 (5 ) ,735-736

Winer L.;Beckmann N.;Veile R.;Goodman M.;Caldwell C.;Nomellini V. (05-01-2019. ) Consumptive coagulopathy is associated with organ dysfunction during PICS.American Journal of Physiology - Lung Cellular and Molecular Physiology, , 316 (5 ) ,L946-L952

Martin G.E.;Pugh A.M.;Moran R.;Veile R.;Friend L.A.;Pritts T.A.;Makley A.T.;Caldwell C.C.;Goodman M.D. (04-01-2019. ) Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine d.Journal of Trauma and Acute Care Surgery, , 86 (4 ) ,592-599

Xia B.T.;Beckmann N.;Winer L.K.;Kim Y.;Goetzman H.S.;Veile R.E.;Gulbins E.;Goodman M.D.;Nomellini V.;Caldwell C.C. (03-01-2019. ) Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.Shock, , 51 (3 ) ,356-363

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. (01-01-2019. ) Cell-specific regulatory effects of CXCR2 on cholestatic liver injury.American Journal of Physiology - Gastrointestinal and Liver Physiology, , 317 (6 ) ,G773-G783

Xia B.;Beckmann N.;Winer L.;Pugh A.;Pritts T.;Nomellini V.;Gulbins E.;Caldwell C. (01-01-2019. ) Amitriptyline reduces inflammation and mortality in a murine model of sepsis.Cellular Physiology and Biochemistry, , 52 (3 ) ,565-579

Gulbins A.;Schumacher F.;Becker K.;Wilker B.;Soddemann M.;Boldrin F.;Müller C.;Edwards M.;Goodman M.;Caldwell C.;Kleuser B.;Kornhuber J.;Szabo I.;Gulbins E. (12-01-2018. ) Antidepressants regulate autophagy by targeting acid sphingomyelinase.Molecular Psychiatry, , 23 (12 ) ,2251

Gulbins A.;Schumacher F.;Becker K.;Wilker B.;Soddemann M.;Boldrin F.;Müller C.;Edwards M.;Goodman M.;Caldwell C.;Kleuser B.;Kornhuber J.;Szabo I.;Gulbins E. (12-01-2018. ) Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide.Molecular Psychiatry, , 23 (12 ) ,2324-2346

Baker J.;Boudreau R.;Seitz A.;Caldwell C.;Gulbins E.;Edwards M. (11-01-2018. ) Sphingolipids and innate immunity: A new approach to infection in the post-antibiotic era?.Surgical Infections, , 19 (8 ) ,792-803

Beckmann N.;Pugh A.;Caldwell C. (10-01-2018. ) Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression.PLoS ONE, , 13 (10 ) ,

Keitsch S.;Riethmüller J.;Soddemann M.;Sehl C.;Wilker B.;Edwards M.;Caldwell C.;Fraunholz M.;Gulbins E.;Becker K. (09-25-2018. ) Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-Toxi.Biological Chemistry, , 399 (10 ) ,1203-1213

Becker K.A.;Riethmüller J.;Seitz A.P.;Gardner A.;Boudreau R.;Kamler M.;Kleuser B.;Schuchman E.;Caldwell C.C.;Edwards M.J.;Grassmé H.;Brodlie M.;Gulbins E. (08-01-2018. ) Sphingolipids as targets for inhalation treatment of cystic fibrosis.Advanced Drug Delivery Reviews, , 133 ,66-75

Mu X.;Wang X.;Huang W.;Wang R.;Essandoh K.;Li Y.;Pugh A.;Peng J.;Deng S.;Wang Y.;Caldwell C.;Peng T.;Yu K.;Fan G. (04-01-2018. ) Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promo.Shock, , 49 (4 ) ,429-441

Kim Y.;Abplanalp W.;Jung A.;Schuster R.;Lentsch A.;Gulbins E.;Caldwell C.;Pritts T. (03-01-2018. ) Endocytosis of red blood cell microparticles by pulmonary endothelial cells is mediated by Rab5.Shock, , 49 (3 ) ,288-294

Kim Y.;Xia B.;Jung A.;Chang A.;Abplanalp W.;Caldwell C.;Goodman M.;Pritts T. (02-01-2018. ) Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of tran.Surgery (United States), , 163 (2 ) ,423-429

Nomellini V.;Kaplan L.;Sims C.;Caldwell C. (01-01-2018. ) Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, S.Shock, , 49 (1 ) ,4-14

Martin G.;Xia B.;Kim Y.;Johnson M.;Veile R.;Friend L.;Makley A.;Caldwell C.;Goodman M. (01-01-2018. ) Platelet function changes in a time-dependent manner following traumatic brain injury in a murine mo.Shock, , 50 (5 ) ,551-556

Becker K.;Fahsel B.;Kemper H.;Mayeres J.;Li C.;Wilker B.;Keitsch S.;Soddemann M.;Sehl C.;Kohnen M.;Edwards M.;Grassmé H.;Caldwell C.;Seitz A.;Fraunholz M.;Gulbins E. (01-01-2018. ) Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinas.Infection and Immunity, , 86 (1 ) ,

Ma J.;Gulbins E.;Edwards M.;Caldwell C.;Fraunholz M.;Becker K. (12-01-2017. ) Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and.Cellular Physiology and Biochemistry, , 43 (6 ) ,2170-2184

Kunz N.;Hauenschild E.;Maass S.;Kalies K.U.;Klinger M.;Barra M.;Hecht L.;Helbig F.;Soellner S.;Caldwell C.C.;Ludwig R.J.;Westermann J.;Kalies K. (12-01-2017. ) Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and .Experimental Dermatology, , 26 (12 ) ,1199-1206

Rice T.;Pugh A.;Seitz A.;Gulbins E.;Nomellini V.;Caldwell C. (11-01-2017. ) Sphingosine rescues aged mice from pulmonary pseudomonas infection.Journal of Surgical Research, , 219 ,354-359

Becker K.;Li X.;Seitz A.;Steinmann J.;Koch A.;Schuchman E.;Kamler M.;Edwards M.;Caldwell C.;Gulbins E. (11-01-2017. ) Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine.Cellular Physiology and Biochemistry, , 43 (4 ) ,1603-1616

Rice T.;Pugh A.;Xia B.;Seitz A.;Whitacre B.;Gulbins E.;Caldwell C. (10-01-2017. ) Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection.Journal of the American College of Surgeons, , 225 (4 ) ,538-547

Johnson B.L.;Midura E.F.;Prakash P.S.;Rice T.C.;Kunz N.;Kalies K.;Caldwell C.C. (10-01-2017. ) Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a muri.Biochimica et Biophysica Acta - Molecular Basis of Disease, , 1863 (10 ) ,2554-2563

Martin G.;Boudreau R.;Couch C.;Becker K.;Edwards M.;Caldwell C.;Gulbins E.;Seitz A. (10-01-2017. ) Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic.Biochimie, , 141 ,91-96

Rice T.;Pugh A.;Caldwell C.;Schneider B. (09-01-2017. ) Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in.Critical Care Nursing Clinics of North America, , 29 (3 ) ,331-340

Kunz N.;Xia B.T.;Kalies K.U.;Klinger M.;Gemoll T.;Habermann J.K.;Whitacre B.E.;Seitz A.P.;Kalies K.;Caldwell C.C. (09-01-2017. ) Cell-Derived Nanoparticles are Endogenous Modulators of Sepsis with Therapeutic Potential.Shock, , 48 (3 ) ,346-354

Pugh A.;Auteri N.;Goetzman H.;Caldwell C.;Nomellini V. (08-10-2017. ) A murine model of persistent inflammation, immune suppression, and catabolism syndrome.International Journal of Molecular Sciences, , 18 (8 ) ,

Boudreau R.M.;Johnson M.;Veile R.;Friend L.A.;Goetzman H.;Caldwell C.C.;Makley A.T.;Goodman M.D. (07-01-2017. ) Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury.Journal of Surgical Research, , 215 ,47-54

Grassmé H.;Henry B.;Ziobro R.;Becker K.A.;Riethmüller J.;Gardner A.;Seitz A.P.;Steinmann J.;Lang S.;Ward C.;Schuchman E.H.;Caldwell C.C.;Kamler M.;Edwards M.J.;Brodlie M.;Gulbins E. (06-14-2017. ) ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingo.Cell Host and Microbe, , 21 (6 ) ,707-718.e8

Rice T.;Armocida S.;Kuethe J.;Midura E.;Jain A.;Hildeman D.;Healy D.;Gulbins E.;Caldwell C. (03-01-2017. ) Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.Cellular Immunology, , 313 ,25-31

Hoehn R.;Jernigan P.;Japtok L.;Chang A.;Midura E.;Caldwell C.;Kleuser B.;Lentsch A.;Edwards M.;Gulbins E.;Pritts T. (01-01-2017. ) Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflamma.Annals of Surgery, , 265 (1 ) ,218-226

Lehmann C.;Burkovskiy I.;Kuethe J.;Zhou J.;Caldwell C.;Kelly M. (01-01-2014. ) Inhibition of the cannabinoid 2 receptor in CNS-injury induced immunodeficiency syndrome.Medical Hypotheses, , 82 (6 ) ,736-739

Siegmann N.;Worbs D.;Effinger F.;Bormann T.;Gebhardt M.;Ulrich M.;Wermeling F.;Müller-Hermelink E.;Biedermann T.;Tighe M.;Edwards M.;Caldwell C.;Leadbetter E.;Karlsson M.;Becker K.;Gulbins E.;Döring G. (01-01-2014. ) Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in c.Cellular Physiology and Biochemistry, , 34 (1 ) ,56-70

Caldwell C.C.;Chen Y.;Goetzmann H.S.;Hao Y.;Borchers M.T.;Hassett D.J.;Young L.R.;Mavrodi D.;Thomashow L.;Lau G.W. (01-01-2009. ) Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis.American Journal of Pathology, , 175 (6 ) ,2473-2488

Nogueiras R.;Veyrat-Durebex C.;Suchanek P.M.;Klein M.;Tschöp J.;Caldwell C.;Woods S.C.;Wittmann G.;Watanabe M.;Liposits Z.;Fekete C.;Reizes O.;Rohner-Jeanrenaud F.;Tschöp M.H. (01-01-2008. ) Peripheral, but Not Central, CB1 antagonism provides food intake-independent metabolic benefits in d.Diabetes, , 57 (11 ) ,2977-2991

Shivakumar P.;Sabla G.;Mohanty S.;McNeal M.;Ward R.;Stringer K.;Caldwell C.;Chougnet C.;Bezerra J. (01-01-2007. ) Effector Role of Neonatal Hepatic CD8+ Lymphocytes in Epithelial Injury and A.Gastroenterology, , 133 (1 ) ,268-277

Thiel M.;Chouker A.;Ohta A.;Jackson E.;Caldwell C.;Smith P.;Lukashev D.;Bittmann I.;Sitkovsky M. (06-01-2005. ) Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inf.PLoS Biology, , 3 (6 ) ,1088-1100

Sitkovsky M.;Lukashev D.;Apasov S.;Kojima H.;Koshiba M.;Caldwell C.;Ohta A.;Thiel M. (06-07-2004. ) Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors.Annual Review of Immunology, , 22 ,657-682

Lukashev D.;Caldwell C.;Ohta A.;Chen P.;Sitkovsky M. (12-28-2001. ) Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1? in Acti.Journal of Biological Chemistry, , 276 (52 ) ,48754-48763

Armstrong J.M.;Chen J.F.;Schwarzschild M.A.;Apasov S.;Smith P.T.;Caldwell C.;Chen P.;Figler H.;Sullivan G.;Fink S.;Linden J.;Sitkovsky M. (02-15-2001. ) Gene dose effect reveals GS-coupled A2A adenosine rece.Biochemical Journal, , 354 (1 ) ,123-130

Caldwell C.;Hornyak S.;Stephen Dahms A. (12-01-1998. ) Probes at the chicken smooth muscle ECTO-ATPASE: A comprehensive regulatory model .FASEB Journal, , 12 (8 ) ,

Stitt O.L.;Davis M.;Caldwell C.;Dahms A.S. (12-01-1998. ) Kinetic differentiation of ecto-aptase sub-families from chicken smooth muscle and liver .FASEB Journal, , 12 (8 ) ,

Caldwell C.;Campbell D.;Gospaderic T.;Dahms A. (12-01-1997. ) Modulation of smooth muscle ecto-atpase activity by lipid covalent/ non-covalent probes .FASEB Journal, , 11 (9 ) ,

Caldwell C.;Norman V.;Urbina A.;Jarvis A.;Quinonez C.;Stemm M.;Dahms A.S. (09-29-1997. ) Regulatory differences among avian Ecto-ATPases.Biochemical and Biophysical Research Communications, , 238 (3 ) ,728-732

Remy, Kenneth E; Mazer, Monty; Striker, David A; Ellebedy, Ali H; Walton, Andrew H; Unsinger, Jacqueline; Blood, Teresa M; Mudd, Philip A; Yi, Daehan J; Mannion, Daniel A; Osborne, Dale F; Martin, R Scott; Anand, Nitin J; Bosanquet, James P; Blood, Jane; Drewry, Anne M; Caldwell, Charles C; Turnbull, Isaiah R; Brakenridge, Scott C; Moldawer, Lyle L; Hotchkiss, Richard S (2020. ) Severe immunosuppression and not a cytokine storm characterize COVID-19 infections.JCI insight, ,

Pulliam, Kasiemobi E; Joseph, Bernadin; Veile, Rosalie A; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A (2020. ) SAVE IT - DON'T WASTE IT! MAXIMIZING UTILIZATION OF ERYTHROCYTES FROM PREVIOUSLY STORED WHOLE BLOOD.The journal of trauma and acute care surgery, ,

Salyer, Christen E; Bomholt, Christina; Beckmann, Nadine; Bergmann, Christian B; Plattner, Courtney A; Caldwell, Charles C (2020. ) Novel Therapeutics for the Treatment of Burn Infection.Surgical infections, ,

Sengupta, Satarupa; Caldwell, Charles C; Nomellini, Vanessa (2020. ) Distinct Neutrophil Populations in the Spleen During PICS.Frontiers in immunology, , 11 ,804

Beckmann, Nadine; Huber, Franziska; Hanschen, Marc; St Pierre Schneider, Barbara; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling.Frontiers in immunology, , 11 ,876

Beckmann, Nadine; Sutton, Jeffrey M; Hoehn, Richard S; Jernigan, Peter L; Friend, Lou Ann; Johanningman, Taylor A; Schuster, Rebecca M; Lentsch, Alex B; Caldwell, Charles C; Pritts, Timothy A (2020. ) IFN? and TNF? mediate CCL22/MDC production in alveolar macrophages after hemorrhage and resuscitation.American journal of physiology. Lung cellular and molecular physiology, , 318 (5 ) ,L864-L872

Beckmann, Nadine; Salyer, Christen E; Crisologo, Peter A; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Staging and Personalized Intervention for Infection and Sepsis.Surgical infections, ,

Konishi, Takanori; Schuster, Rebecca M; Goetzman, Holly S; Caldwell, Charles C; Lentsch, Alex B (2020. ) Fibrotic liver has prompt recovery after ischemia-reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 318 (3 ) ,G390-G400

Kim, Young; Goodman, Michael D; Jung, Andrew D; Abplanalp, William A; Schuster, Rebecca M; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A (2020. ) Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via P-selectin.Thrombosis research, , 185 ,160-166

Konishi, Takanori; Schuster, Rebecca M; Goetzman, Holly S; Caldwell, Charles C; Lentsch, Alex B (2019. ) Cell-specific regulatory effects of CXCR2 on cholestatic liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 317 (6 ) ,G773-G783

Hefele, Friederike; Ditsch, Alexander; Krysiak, Niels; Caldwell, Charles C; Biberthaler, Peter; van Griensven, Martijn; Huber-Wagner, Stefan; Hanschen, Marc (2019. ) Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Platelet Dysfunction.Frontiers in immunology, , 10 ,2389

Seitz, Aaron P; Schumacher, Fabian; Baker, Jennifer; Soddemann, Matthias; Wilker, Barbara; Caldwell, Charles C; Gobble, Ryan M; Kamler, Markus; Becker, Katrin Anne; Beck, Sascha; Kleuser, Burkhard; Edwards, Michael J; Gulbins, Erich (2019. ) Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia.Journal of molecular medicine (Berlin, Germany), , 97 (8 ) ,1195-1211

Winer, Leah K; Beckmann, Nadine; Veile, Rosalie A; Goodman, Michael D; Caldwell, Charles C; Nomellini, Vanessa (2019. ) Consumptive coagulopathy is associated with organ dysfunction during PICS.American journal of physiology. Lung cellular and molecular physiology, , 316 (5 ) ,L946-L952

Crouser, Elliott D; Caldwell, Charles C; Hotchkiss, Richard S (2019. ) What Is the Skinny on Obesity During Sepsis?.Critical care medicine, , 47 (5 ) ,735-736

Martin, Grace E; Pugh, Amanda M; Moran, Ryan; Veile, Rose; Friend, Lou Ann; Pritts, Timothy A; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D (2019. ) Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine diphosphate receptor.The journal of trauma and acute care surgery, , 86 (4 ) ,592-600

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Kim, Young; Goetzman, Holly S; Veile, Rosalie E; Gulbins, Erich; Goodman, Michael D; Nomellini, Vanessa; Caldwell, Charles C (2019. ) Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.Shock (Augusta, Ga.), , 51 (3 ) ,356-363

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Pugh, Amanda M; Pritts, Timothy A; Nomellini, Vanessa; Gulbins, Erich; Caldwell, Charles C (2019. ) Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 52 (3 ) ,565-579

Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P; Edwards, Michael J; Goodman, Michael; Caldwell, Charles C; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich (2018. ) Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.Molecular psychiatry, , 23 (12 ) ,2324-2346

Martin, Grace E; Xia, Brent; Kim, Young; Johnson, Mark D; Veile, Rosalie; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D (2018. ) Platelet Function Changes in a Time-Dependent Manner Following Traumatic Brain Injury in a Murine Model.Shock (Augusta, Ga.), , 50 (5 ) ,551-556

Baker, Jennifer E; Boudreau, Ryan M; Seitz, Aaron P; Caldwell, Charles C; Gulbins, Erich; Edwards, Michael J Sphingolipids and Innate Immunity: A New Approach to Infection in the Post-Antibiotic Era?.Surgical infections, , 19 (8 ) ,792-803

Beckmann, Nadine; Pugh, Amanda M; Caldwell, Charles C (2018. ) Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression.PloS one, , 13 (10 ) ,e0205307

Keitsch, Simone; Riethmüller, Joachim; Soddemann, Matthias; Sehl, Carolin; Wilker, Barbara; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Gulbins, Erich; Becker, Katrin Anne (2018. ) Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-toxin.Biological chemistry, , 399 (10 ) ,1203-1213

Becker, Katrin Anne; Riethmüller, Joachim; Seitz, Aaron P; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C; Edwards, Michael J; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich (2018. ) Sphingolipids as targets for inhalation treatment of cystic fibrosis.Advanced drug delivery reviews, , 133 ,66-75

Mu, Xingjiang; Wang, Xiaohong; Huang, Wei; Wang, Rui-Tao; Essandoh, Kobina; Li, Yutian; Pugh, Amanda M; Peng, Jiangtong; Deng, Shan; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Yu, Kai-Jiang; Fan, Guo-Chang (2018. ) Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation.Shock (Augusta, Ga.), , 49 (4 ) ,429-441

Kim, Young; Abplanalp, William A; Jung, Andrew D; Schuster, Rebecca M; Lentsch, Alex B; Gulbins, Erich; Caldwell, Charles C; Pritts, Timothy A (2018. ) Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5.Shock (Augusta, Ga.), , 49 (3 ) ,288-294

Kim, Young; Xia, Brent T; Jung, Andrew D; Chang, Alex L; Abplanalp, William A; Caldwell, Charles C; Goodman, Michael D; Pritts, Timothy A (2018. ) Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion.Surgery, , 163 (2 ) ,423-429

Nomellini, Vanessa; Kaplan, Lewis J; Sims, Carrie A; Caldwell, Charles C (2018. ) Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, Septic, and Malnourished?.Shock (Augusta, Ga.), , 49 (1 ) ,4-14

Becker, Katrin Anne; Fahsel, Björn; Kemper, Hannes; Mayeres, Joelina; Li, Cao; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Sehl, Carolin; Kohnen, Marcus; Edwards, Michael J; Grassmé, Heike; Caldwell, Charles C; Seitz, Aaron; Fraunholz, Martin; Gulbins, Erich (2018. ) Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide.Infection and immunity, , 86 (1 ) ,

Kunz, Natalia; Hauenschild, Eva; Maass, Sebastian; Kalies, Kai-Uwe; Klinger, Matthias; Barra, Melanie; Hecht, Lars; Helbig, Franz; Soellner, Stefan; Caldwell, Charles C; Ludwig, Ralf J; Westermann, Jürgen; Kalies, Kathrin (2017. ) Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and wound re-epithelialization in human skin.Experimental dermatology, , 26 (12 ) ,1199-1206

Rice, Teresa C; Pugh, Amanda M; Seitz, Aaron P; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C (2017. ) Sphingosine rescues aged mice from pulmonary pseudomonas infection.The Journal of surgical research, , 219 ,354-359

Johnson, Bobby L; Midura, Emily F; Prakash, Priya S; Rice, Teresa C; Kunz, Natalia; Kalies, Kathrin; Caldwell, Charles C (2017. ) Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a murine model of sepsis.Biochimica et biophysica acta. Molecular basis of disease, , 1863 (10 Pt B ) ,2554-2563

Martin, Grace E; Boudreau, Ryan M; Couch, Caroline; Becker, Katrin Anne; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Seitz, Aaron (2017. ) Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic.Biochimie, , 141 ,91-96

Rice, Teresa C; Pugh, Amanda M; Xia, Brent T; Seitz, Aaron P; Whitacre, Brynne E; Gulbins, Erich; Caldwell, Charles C (2017. ) Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection.Journal of the American College of Surgeons, , 225 (4 ) ,538-547

Rice, Teresa C; Pugh, Amanda M; Caldwell, Charles C; Schneider, Barbara St Pierre (2017. ) Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in Sepsis.Critical care nursing clinics of North America, , 29 (3 ) ,331-340

Kunz, Natalia; Xia, Brent T; Kalies, Kai-Uwe; Klinger, Matthias; Gemoll, Timo; Habermann, Jens K; Whitacre, Brynne E; Seitz, Aaron P; Kalies, Kathrin; Caldwell, Charles C (2017. ) Cell-Derived Nanoparticles are Endogenous Modulators of Sepsis With Therapeutic Potential.Shock (Augusta, Ga.), , 48 (3 ) ,346-354

Pugh, Amanda M; Auteri, Nicholas J; Goetzman, Holly S; Caldwell, Charles C; Nomellini, Vanessa (2017. ) A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome.International journal of molecular sciences, , 18 (8 ) ,

Boudreau, Ryan M; Johnson, Mark; Veile, Rosalie; Friend, Lou Ann; Goetzman, Holly; Pritts, Timothy A; Caldwell, Charles C; Makley, Amy T; Goodman, Michael D (2017. ) Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury and hemorrhage.The Journal of surgical research, , 215 ,47-54

Grassmé, Heike; Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Riethmüller, Joachim; Gardner, Aaron; Seitz, Aaron P; Steinmann, Joerg; Lang, Stephan; Ward, Christopher; Schuchman, Edward H; Caldwell, Charles C; Kamler, Markus; Edwards, Michael J; Brodlie, Malcolm; Gulbins, Erich (2017. ) ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections.Cell host & microbe, , 21 (6 ) ,707-718.e8

Rice, Teresa C; Armocida, Stephanie M; Kuethe, Joshua W; Midura, Emily F; Jain, Ayushi; Hildeman, David A; Healy, Daniel P; Gulbins, Erich; Caldwell, Charles C (2017. ) Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.Cellular immunology, , 313 ,25-31

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2017. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, , 265 (1 ) ,218-226

Ma, Jie; Gulbins, Erich; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Becker, Katrin Anne (2017. ) Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 43 (6 ) ,2170-2184

Becker, Katrin Anne; Li, Xiang; Seitz, Aaron; Steinmann, Joerg; Koch, Anne; Schuchman, Edward; Kamler, Markus; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich (2017. ) Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 43 (4 ) ,1603-1616

Contact Information

Academic - Medical Sciences Building
SRU Room G479
Cincinnati  Ohio, 45267
Phone: 513-558-1974
charles.caldwell@uc.edu