Charles Caldwell

Charles C. Caldwell , PhD

Professor

Director, Division of Research

Medical Sciences Building
SRU Room G479
231 Albert Sabin Way
Cincinnati, Ohio 45267
Phone 513-558-1974
Email charles.caldwell@uc.edu

Professional Summary

Professor
Director, Division of Reseach
Department of Surgery

Education

Bachelor's Degree: University of California - San Diego 1991 (Chemistry)

Doctoral Degree: San Diego State University 1998 (Biochemistry)

Postdoctoral Training: National Institutes of Health 2003 (Immunology)

Research and Practice Interests

Host Immune Response to Sepsis and Trauma Injury

Research Support

Grant: #NIH/NIGMS R01 GM72760-01 Investigators:Charles C. Caldwell, PhD 09-01-2005 -08-30-2010 NIH Role of HIF-1a in T Cells During Sepsis Role:PI $163,000 yearly Active Type:Grant

Grant: #8904 Investigators:Charles Caldwell PhD 01-01-2007 -12-31-2009 The Shriners Hospital for Children The Role of Adenosine A2a Receptor Following Thermal Injury Role:PI $162,000 yearly Active Type:Grant

Grant: #NIH/NIDDK 5R01DK56029-06-10 Investigators:Charles Caldwell PhD 09-01-2004 -08-30-2009 NIH Regulation of Hepatic Ischemia/Reperfusion Injury Role:Co-PI $250,000 yearly Active Type:Grant

Grant: #NIH/NICHD R01 HD36888 Competitive Renewal Investigators:Chares Caldwell PhD 09-01-2005 -06-30-2010 NIH The Hepatocyte Growth Factor-Like Protein Receptor Role:Co-PI Active Type:Grant

Grant: #1-R01-GM-072760 Investigators:Caldwell, Charles 09-01-2005 -08-31-2011 National Institute of General Medical Sciences Role of HIF-1a in T Cells During Sepsis Role:PI $1,212,544.00 Closed Level:Federal

Investigators:Caldwell, Charles 07-01-2004 -06-30-2005 Pfizer, Inc. The Role of HIF in Atherosclerosis Role:PI $50,000.00 Closed Level:Industry

Grant: #IIRA-GA9001TG Investigators:Caldwell, Charles; Hassett, Daniel; Solomkin, Joseph 08-08-2008 -06-30-2010 Pfizer, Inc. Induction of PVL Production in Neutrophil Phagosomes: Cell Protection By Bacterial Protein Synthesis Inhibition and Its Effect on Infectious Mortality Role:Collaborator $60,787.50 Active Level:Industry

Grant: #3 R01 GM072760-04S1 Investigators:Caldwell, Charles 08-13-2009 -08-31-2010 National Institute of General Medical Sciences Role of HIF-1a in T Cells During Sepsis Role:PI $9,613.00 Closed Level:Federal

Grant: #W81XWH-09-1-0625 Investigators:Caldwell, Charles; Lentsch, Alex 09-03-2009 -09-02-2012 Department of the Army Medical Research Acquisition Activity Effects of Different Fluid Resuscitation Strategies on Systemic Inflammation, Immunocompromise, Organ Dysfunction and Death Role:Collaborator $708,840.00 Closed Level:Federal

Grant: #FA8650-11-2-6B05 Task 5 Investigators:Branson, Richard; Caldwell, Charles; Johannigman, Jay; Lentsch, Alex; Pritts, Timothy 11-23-2010 -11-22-2012 Air Force Research Laboratory Determining the Oxygen Requirements Using an Oxygen Concentrator at Altitude Role:Collaborator $776,561.00 Active Level:Federal

Grant: #R01GM100913 Investigators:Caldwell, Charles 12-15-2012 -11-30-2016 National Institute of General Medical Sciences Neutrophil-derived Microparticle Generation and Immune Impact During Sepsis Role:PI $299,539.00 Active Level:Federal

Grant: #13-708B-B-00 / FA7014-10-2-0001 Investigators:Caldwell, Charles 03-15-2013 -12-31-2013 Department of the Air Force Determining How Hyperbaria Impacts the Immune Response to Crush Injury Role:PI $74,135.00 Active Level:Federal

Grant: #R01 GM107625 Investigators:Caldwell, Charles; Lentsch, Alex; Pritts, Timothy 02-01-2014 -12-31-2018 National Institute of General Medical Sciences Red blood cell microparticles and lung inflammation after hemorrhage and resuscit Role:Collaborator $313,038.00 Awarded Level:Federal

Grant: #FA8650-14-2-6B20 under Master FA8650-10-2-6140 Investigators:Caldwell, Charles; Lentsch, Alex; Pritts, Timothy 05-23-2014 -05-22-2015 Air Force Research Laboratory Effect of pRBC Cryopreservation on Development of the Storage Lesion and Inflammation Role:Collaborator $247,143.00 Active Level:Federal

Grant: #1 R01 GM112930 Investigators:Caldwell, Charles; Fan, Guochang 01-01-2015 -12-31-2018 National Institute of General Medical Sciences Duplex miR-223 and Exosomes in Sepsis Role:Collaborator $307,928.00 Awarded Level:Federal

Grant: #FA8650-16-2-6G03 (task under Master FA8650-15-2-6605) Investigators:Blakeman, Thomas; Caldwell, Charles; Goodman, Michael; Makley, Amy; Pritts, Timothy 02-22-2016 -02-21-2018 Air Force Research Laboratory A Randomized Controlled Trial for Early Identification and Prevention of Acute Lung Injury After Hemorrhage Role:Collaborator $349,000.00 Awarded Level:Federal

Grant: #FA8650-16-2-6G05 (Task under Master FA8650-15-2-6605) Investigators:Caldwell, Charles; Goodman, Michael; Lentsch, Alex; Makley, Amy; Pritts, Timothy; Robinson, Bryce 02-26-2016 -02-25-2019 Air Force Research Laboratory Effect of fluid resuscitation strategy during en route care on acute lung injury after hemorrhage and burn injury. Role:Collaborator $396,000.00 Awarded Level:Federal

Grant: #17-931D-01 / W81XWH-16-1-0150 Investigators:Caldwell, Charles 07-20-2016 -07-19-2020 Department of the Army Medical Research Acquisition Activity The Effect of Hypobaria on Muscle Inflammation and Regeneration after Injury and Hemorrhagic Shock Role:PI $76,632.00 Active Level:Federal

Grant: #R01GM124156 Investigators:Caldwell, Charles; Goodman, Michael; Gulbins, Erich 05-01-2018 -04-30-2023 National Institute of General Medical Sciences Role of acid sphingomyelinase in the modulation of coagulation after traumatic brain injury Role:Collaborator $303,842.00 Awarded Level:Federal

Grant: #R01-GM-132149 Investigators:Caldwell, Charles; Fan, Guochang 04-01-2019 -03-31-2023 National Institutes of Health Roles of Sectm1a in macrophages and cardiac function during sepsis Role:Collaborator $304,713.00 Awarded Level:Federal

Grant: #R01 GM107625-06A1 Investigators:Caldwell, Charles; Gulbins, Erich; Lentsch, Alex; Pritts, Timothy 02-01-2014 -03-31-2023 National Institutes of Health Red blood cell microparticles and lung inflammation after hemorrhage and resuscitation Role:Collaborator $352,825.00 Awarded Level:Federal

Grant: #VA IPA Caldwell Investigators:Caldwell, Charles 07-01-2019 -06-30-2020 Department of Veterans Affairs IPA for Charles Caldwell - VA Merit Award for Rajat Madan Role:PI $7,072.64 Awarded Level:Federal

Grant: #Shriners 85800-CIN-17 Investigators:Caldwell, Charles 01-01-2020 -12-31-2020 Shriners Hospitals for Children - Cincinnati Epoxyeicosatrienoic Acids: Therapeutic Potential in Skin Grafting and Burns Role:PI $17,380.00 Awarded Level:Private Non-Profit

Grant: #85219-CIN-17 Investigators:Caldwell, Charles; Gulbins, Erich; Nomellini, Vanessa 01-01-2020 -12-31-2022 Shriners Hospitals for Children - Cincinnati Ceramide regulatory role upon neutrophil chemotaxis after burn injury Role:PI $249,873.00 Active Level:Private Non-Profit

Grant: #Shriners 85000 Investigators:Caldwell, Charles; Dale, Elizabeth; Gulbins, Erich 01-01-2020 -12-31-2021 Shriners Hospitals for Children - Cincinnati Exploiting bioactive lipid properties to rescue burn-injured mice from lung infection Role:PI $.00 Active Level:Private Non-Profit

Grant: #R35GM138020 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-01-2020 -06-30-2025 National Institute of General Medical Sciences Utilizing Immune Phenotypes to Prevent Chronic Critical Illness Role:Collaborator $401,250.00 Awarded Level:Federal

Grant: #SUB00002421 / R01GM139046 Investigators:Caldwell, Charles; Nomellini, Vanessa 09-05-2020 -06-30-2025 National Institute of General Medical Sciences Stratifying Patient Immune Endotypes in Sepsis (SPIES Study) Role:PI $159,799.00 Awarded Level:Federal

Grant: #FA8650-21-2-6285 Investigators:Blakeman, Thomas; Branson, Richard; Caldwell, Charles; Gomaa, Dina; Goodman, Michael; Lentsch, Alex; McMullan, Jason; Pritts, Timothy 09-30-2021 -09-29-2027 Air Force Research Laboratory Expeditionary Medicine, Trauma, and Enroute Care (EMTEC) Research and Technology Development Co-op Agreement Role:Collaborator 49000000.00 Hold Level:Federal

Publications

Peer Reviewed Publications

Midura, Emily F; Jernigan, Peter L; Kuethe, Joshua W; Friend, Lou Ann; Veile, Rosalie; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D (2015. ) Microparticles impact coagulation after traumatic brain injury.The Journal of surgical research, , 197 (1 ) ,25-31 More Information

Kuethe, Joshua W; Midura, Emily F; Rice, Teresa C; Caldwell, Charles C (2015. ) Peritoneal wash contents used to predict mortality in a murine sepsis model.The Journal of surgical research, , More Information

Wilson, Gregory C; Freeman, Christopher M; Kuethe, Joshua W; Quillin, Ralph C; Nojima, Hiroyuki; Schuster, Rebecca; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B (2015. ) CXC chemokine receptor-4 signaling limits hepatocyte proliferation after hepatic ischemia-reperfusion in mice.American journal of physiology. Gastrointestinal and liver physiology, , 308 (8 ) ,G702-9 More Information

Siegl, Daniel; Midura, Emily F; Annecke, Thorsten; Conzen, Peter; Caldwell, Charles C; Tschoep, Johannes (2015. ) The effect of ghrelin upon the early immune response in lean and obese mice during sepsis.PloS one, , 10 (4 ) ,e0122211 More Information

Kuethe, Joshua W; Mintz-Cole, Rachael; Johnson, Bobby L; Midura, Emily F; Caldwell, Charles C; Schneider, Barbara St Pierre Assessing the immune status of critically ill trauma patients by flow cytometry.Nursing research, , 63 (6 ) ,426-34 More Information

Yang, Sung; Stepien, David; Hanseman, Dennis; Robinson, Bryce; Goodman, Michael D; Pritts, Timothy A; Caldwell, Charles C; Remick, Daniel G; Lentsch, Alex B (2014. ) Substance P mediates reduced pneumonia rates after traumatic brain injury.Critical care medicine, , 42 (9 ) ,2092-100 More Information

Kuethe, Joshua W; Prakash, Priya S; Midura, Emily F; Johnson, Bobby L; Kasten, Kevin R; Caldwell, Charles C (2014. ) Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis.The Journal of surgical research, , 191 (1 ) ,19-24 More Information

Siegl, Daniel; Annecke, Thorsten; Johnson, Bobby L; Schlag, Christian; Martignoni, Andre; Huber, Nadine; Conzen, Peter; Caldwell, Charles C; Tschöp, Johannes (2014. ) Obesity-induced hyperleptinemia improves survival and immune response in a murine model of sepsis.Anesthesiology, , 121 (1 ) ,98-114 More Information

Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang (2014. ) Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis.Biochimica et biophysica acta, , 1842 (5 ) ,701-11 More Information

Lehmann, Christian; Sharawi, Nivin; Al-Banna, Nadia; Corbett, Nathan; Kuethe, Joshua W; Caldwell, Charles C (2014. ) Novel approaches to the development of anti-sepsis drugs.Expert opinion on drug discovery, , 9 (5 ) ,523-31 More Information

Johnson, Bobby L; Iii, ; Kuethe, Josh W; Caldwell, Charles C (2014. ) Neutrophil derived microvesicles: emerging role of a key mediator to the immune response. Endocrine, metabolic & immune disorders drug targets, , 14 (3 ) ,210-7

Freeman, Christopher M; Quillin, Ralph C; Wilson, Gregory C; Nojima, Hiroyuki; Johnson, Bobby L; Sutton, Jeffrey M; Schuster, Rebecca M; Blanchard, John; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B (2014. ) Characterization of microparticles after hepatic ischemia-reperfusion injury.PloS one, , 9 (5 ) ,e97945 More Information

Johnson, Bobby L; Goetzman, Holly S; Prakash, Priya S; Caldwell, Charles C (2013. ) Mechanisms underlying mouse TNF-? stimulated neutrophil derived microparticle generation.Biochemical and biophysical research communications, , 437 (4 ) ,591-6 More Information

Van Sweringen, Heather L; Sakai, Nozomu; Quillin, Ralph C; Bailey, Jeff; Schuster, Rebecca; Blanchard, John; Goetzman, Holly; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B (2013. ) Roles of hepatocyte and myeloid CXC chemokine receptor-2 in liver recovery and regeneration after ischemia/reperfusion in mice.Hepatology (Baltimore, Md.), , 57 (1 ) ,331-8 More Information

Nowak, Jeffrey E; Harmon, Kelli; Caldwell, Charles C; Wong, Hector R (2012. ) Prophylactic zinc supplementation reduces bacterial load and improves survival in a murine model of sepsis.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, , 13 (5 ) ,e323-9 More Information

Unsinger, Jacqueline; Burnham, Carey-Ann D; McDonough, Jacquelyn; Morre, Michel; Prakash, Priya S; Caldwell, Charles C; Dunne, W Michael; Hotchkiss, Richard S (2012. ) Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.The Journal of infectious diseases, , 206 (4 ) ,606-16 More Information

Prakash, Priya S; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A; Robinson, Bryce R H (2012. ) Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response.The journal of trauma and acute care surgery, , 73 (2 ) ,401-6; discussion 40 More Information

Belizaire, Ritha M; Prakash, Priya S; Richter, Jillian R; Robinson, Bryce R; Edwards, Michael J; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A (2012. ) Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation.Journal of the American College of Surgeons, , 214 (4 ) ,648-55; discussion 6 More Information

Standage, Stephen W; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector R (2012. ) Reduced peroxisome proliferator-activated receptor ? expression is associated with decreased survival and increased tissue bacterial load in sepsis.Shock (Augusta, Ga.), , 37 (2 ) ,164-9 More Information

Caldwell, Charles C; Hotchkiss, Richard S (2011. ) The first step in utilizing immune-modulating therapies: immune status determination.Critical care (London, England), , 15 (1 ) ,108 More Information

Clarke, Callisia; Kuboki, Satoshi; Sakai, Nozomu; Kasten, Kevin R; Tevar, Amit D; Schuster, Rebecca; Blanchard, John; Caldwell, Charles C; Edwards, Michael J; Lentsch, Alex B (2011. ) CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury.Hepatology (Baltimore, Md.), , 53 (1 ) ,261-71 More Information

Tschöp, Johannes; Dattilo, Jonathan R; Prakash, Priya S; Kasten, Kevin R; Tschöp, Matthias H; Caldwell, Charles C (2010. ) The leptin system: a potential target for sepsis induced immune suppression. Endocrine, metabolic & immune disorders drug targets, , 10 (4 ) ,336-47

Kasten, Kevin R; Prakash, Priya S; Unsinger, Jacqueline; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Seitz, Aaron P; Mazuski, Cristina N; Zhou, Tony T; Morre, Michel; Hotchkiss, Richard S; Hildeman, David A; Caldwell, Charles C (2010. ) Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.Infection and immunity, , 78 (11 ) ,4714-22 More Information

Kasten, Kevin R; Tschöp, Johannes; Goetzman, Holly S; England, Lisa G; Dattilo, Jonathan R; Cave, Cindy M; Seitz, Aaron P; Hildeman, David A; Caldwell, Charles C (2010. ) T-cell activation differentially mediates the host response to sepsis.Shock (Augusta, Ga.), , 34 (4 ) ,377-83 More Information

Kasten, Kevin R; Tschöp, Johannes; Adediran, Samuel G; Hildeman, David A; Caldwell, Charles C (2010. ) T cells are potent early mediators of the host response to sepsis.Shock (Augusta, Ga.), , 34 (4 ) ,327-36 More Information

Adediran, Samuel G; Dauplaise, Derrick J; Kasten, Kevin R; Tschöp, Johannes; Dattilo, Jonathan; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Robinson, Chad T; Caldwell, Charles C (2010. ) Early infection during burn-induced inflammatory response results in increased mortality and p38-mediated neutrophil dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology, , 299 (3 ) ,R918-25 More Information

Kasten, Kevin Richard; Tschöp, Johannes; Tschöp, Matthias Hans; Caldwell, Charles Curtis (2010. ) The cannabinoid 2 receptor as a potential therapeutic target for sepsis. Endocrine, metabolic & immune disorders drug targets, , 10 (3 ) ,224-34

Tschöp, Johannes; Nogueiras, Ruben; Haas-Lockie, Sarah; Kasten, Kevin R; Castañeda, Tamara R; Huber, Nadine; Guanciale, Kelsey; Perez-Tilve, Diego; Habegger, Kirk; Ottaway, Nickki; Woods, Stephen C; Oldfield, Brian; Clarke, Iain; Chua, Streamson; Farooqi, I Sadaf; O'Rahilly, Stephen; Caldwell, Charles C; Tschöp, Matthias H (2010. ) CNS leptin action modulates immune response and survival in sepsis.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (17 ) ,6036-47 More Information

Unsinger, Jacqueline; McGlynn, Margaret; Kasten, Kevin R; Hoekzema, Andrew S; Watanabe, Eizo; Muenzer, Jared T; McDonough, Jacquelyn S; Tschoep, Johannes; Ferguson, Thomas A; McDunn, Jonathan E; Morre, Michel; Hildeman, David A; Caldwell, Charles C; Hotchkiss, Richard S (2010. ) IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.Journal of immunology (Baltimore, Md. : 1950), , 184 (7 ) ,3768-79 More Information

Kasten, Kevin R; Muenzer, Jared T; Caldwell, Charles C (2010. ) Neutrophils are significant producers of IL-10 during sepsis.Biochemical and biophysical research communications, , 393 (1 ) ,28-31 More Information

Kasten, Kevin R; Goetzman, Holly S; Reid, Maria R; Rasper, Alison M; Adediran, Samuel G; Robinson, Chad T; Cave, Cindy M; Solomkin, Joseph S; Lentsch, Alex B; Johannigman, Jay A; Caldwell, Charles C (2010. ) Divergent adaptive and innate immunological responses are observed in humans following blunt trauma.BMC immunology, , 11 ,4 More Information

Caldwell, Charles C; Chen, Yi; Goetzmann, Holly S; Hao, Yonghua; Borchers, Michael T; Hassett, Daniel J; Young, Lisa R; Mavrodi, Dmitri; Thomashow, Linda; Lau, Gee W (2009. ) Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis.The American journal of pathology, , 175 (6 ) ,2473-88 More Information

Tschöp, Johannes; Kasten, Kevin R; Nogueiras, Ruben; Goetzman, Holly S; Cave, Cynthia M; England, Lisa G; Dattilo, Jonathan; Lentsch, Alex B; Tschöp, Matthias H; Caldwell, Charles C (2009. ) The cannabinoid receptor 2 is critical for the host response to sepsis.Journal of immunology (Baltimore, Md. : 1950), , 183 (1 ) ,499-505 More Information

Kuboki, Satoshi; Sakai, Nozomu; Tschöp, Johannes; Edwards, Michael J; Lentsch, Alex B; Caldwell, Charles C (2009. ) Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 296 (5 ) ,G1054-9 More Information

Hassett, Daniel J; Sutton, Mark D; Schurr, Michael J; Herr, Andrew B; Caldwell, Charles C; Matu, Joseph O (2009. ) Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways.Trends in microbiology, , 17 (3 ) ,130-8 More Information

Tschöp, Johannes; Martignoni, André; Reid, Maria D; Adediran, Samuel G; Gardner, Jason; Noel, Greg J; Ogle, Cora K; Neely, Alice N; Caldwell, Charles C (2009. ) Differential immunological phenotypes are exhibited after scald and flame burns.Shock (Augusta, Ga.), , 31 (2 ) ,157-63 More Information

Caldwell, Charles C; Lentsch, Alex B (2008. ) Ischemia-driven expression of CD73 confers tissue protection during liver ischemia/reperfusion.Gastroenterology, , 135 (5 ) ,1460-2 More Information

Caldwell, Charles C; Martignoni, Andre; Leonis, Mike A; Ondiveeran, Hari Kumar; Fox-Robichaud, Alison E; Waltz, Susan E (2008. ) Ron receptor tyrosine kinase-dependent hepatic neutrophil recruitment and survival benefit in a murine model of bacterial peritonitis.Critical care medicine, , 36 (5 ) ,1585-93 More Information

Martignoni, André; Tschöp, Johannes; Goetzman, Holly S; Choi, Lisa G; Reid, Maria D; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C (2008. ) CD4-expressing cells are early mediators of the innate immune system during sepsis.Shock (Augusta, Ga.), , 29 (5 ) ,591-7 More Information

Tschöp, Johannes; Martignoni, André; Goetzman, Holly S; Choi, Lisa G; Wang, Quan; Noel, John G; Ogle, Cora K; Pritts, Timothy A; Johannigman, Jay A; Lentsch, Alex B; Caldwell, Charles C (2008. ) Gammadelta T cells mitigate the organ injury and mortality of sepsis.Journal of leukocyte biology, , 83 (3 ) ,581-8 More Information

Noel, John G; Osterburg, Andrew; Wang, Quan; Guo, Xialing; Byrum, Denise; Schwemberger, Sandy; Goetzman, Holly; Caldwell, Charles C; Ogle, Cora K (2007. ) Thermal injury elevates the inflammatory monocyte subpopulation in multiple compartments.Shock (Augusta, Ga.), , 28 (6 ) ,684-93 More Information

Thiel, Manfred; Caldwell, Charles C; Kreth, Simone; Kuboki, Satoshi; Chen, P; Smith, Patrick; Ohta, Akio; Lentsch, Alex B; Lukashev, Dmitry; Sitkovsky, Michail V (2007. ) Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.PloS one, , 2 (9 ) ,e853 More Information

Caldwell, Charles C; Tschoep, Johannes; Lentsch, Alex B (2007. ) Lymphocyte function during hepatic ischemia/reperfusion injury.Journal of leukocyte biology, , 82 (3 ) ,457-64 More Information

Huang, Julie H; Cárdenas-Navia, L Isabel; Caldwell, Charles C; Plumb, Troy J; Radu, Caius G; Rocha, Paulo N; Wilder, Tuere; Bromberg, Jonathan S; Cronstein, Bruce N; Sitkovsky, Michail; Dewhirst, Mark W; Dustin, Michael L (2007. ) Requirements for T lymphocyte migration in explanted lymph nodes. Journal of immunology (Baltimore, Md. : 1950), , 178 (12 ) ,7747-55

Wetzel, Cynthia C; Leonis, Mike A; Dent, Arlene; Olson, Meredith A; Longmeier, Angela M; Ney, Paul A; Boivin, Greg P; Kader, Sarah A; Caldwell, Charles C; Degen, Sandra J F; Waltz, Susan E (2007. ) Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 292 (1 ) ,G253-61 More Information

Caldwell, Charles C; Okaya, Tomohisa; Martignoni, Andre; Husted, Thomas; Schuster, Rebecca; Lentsch, Alex B (2005. ) Divergent functions of CD4+ T lymphocytes in acute liver inflammation and injury after ischemia-reperfusion.American journal of physiology. Gastrointestinal and liver physiology, , 289 (5 ) ,G969-76 More Information

Okaya, Tomohisa; Blanchard, John; Schuster, Rebecca; Kuboki, Satoshi; Husted, Thomas; Caldwell, Charles C; Zingarelli, Basilia; Wong, Hector; Solomkin, Joseph S; Lentsch, Alex B (2005. ) Age-dependent responses to hepatic ischemia/reperfusion injury. Shock (Augusta, Ga.), , 24 (5 ) ,421-7

Noel, John G; Guo, Xialing; Wells-Byrum, Denise; Schwemberger, Sandy; Caldwell, Charles C; Ogle, Cora K (2005. ) Effect of thermal injury on splenic myelopoiesis. Shock (Augusta, Ga.), , 23 (2 ) ,115-22

Olah, Mark E; Caldwell, Charles C (2003. ) Adenosine receptors and mammalian toll-like receptors: synergism in macrophages.Molecular interventions, , 3 (7 ) ,370-4 More Information

Lukashev, Dmitriy E; Smith, Patrick T; Caldwell, Charles C; Ohta, Akio; Apasov, Sergey G; Sitkovsky, Michail V (2003. ) Analysis of A2a receptor-deficient mice reveals no significant compensatory increases in the expression of A2b, A1, and A3 adenosine receptors in lymphoid organs. Biochemical pharmacology, , 65 (12 ) ,2081-90

Thiel, Manfred; Caldwell, Charles C; Sitkovsky, Michail V (2003. ) The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases. Microbes and infection / Institut Pasteur, , 5 (6 ) ,515-26

Wen, Long T; Caldwell, Charles C; Knowles, Aileen F (2003. ) Poly(ADP-ribose) polymerase activation and changes in Bax protein expression associated with extracellular ATP-mediated apoptosis in human embryonic kidney 293-P2X7 cells. Molecular pharmacology, , 63 (3 ) ,706-13

Lukashev, Dmitriy E; Caldwell, Charles C; Chen, Pearl; Apasov, Sergey G; Margulies, David H; Sitkovsky, Michail V (2003. ) A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.Journal of receptor and signal transduction research, , 23 (1 ) ,33-52 More Information

Kojima, Hidefumi; Gu, Hua; Nomura, Saeko; Caldwell, Charles C; Kobata, Tetsuji; Carmeliet, Peter; Semenza, Gregg L; Sitkovsky, Michail V (2002. ) Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice.Proceedings of the National Academy of Sciences of the United States of America, , 99 (4 ) ,2170-4 More Information

Caldwell, C C; Kojima, H; Lukashev, D; Armstrong, J; Farber, M; Apasov, S G; Sitkovsky, M V (2001. ) Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. Journal of immunology (Baltimore, Md. : 1950), , 167 (11 ) ,6140-9

Caldwell, C C; Hornyak, S C; Pendleton, E; Campbell, D; Knowles, A F (2001. ) Regulation of chicken gizzard ecto-ATPase activity by modulators that affect its oligomerization status.Archives of biochemistry and biophysics, , 387 (1 ) ,107-16 More Information

Zhou, P; Freidag, B L; Caldwell, C C; Seder, R A (2001. ) Perforin is required for primary immunity to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), , 166 (3 ) ,1968-74

Redegeld, F A; Caldwell, C C; Sitkovsky, M V (1999. ) Ecto-protein kinases: ecto-domain phosphorylation as a novel target for pharmacological manipulation? .Trends in pharmacological sciences, , 20 (11 ) ,453-9

Caldwell, C C; Davis, M D; Knowles, A F (1999. ) Ectonucleotidases of avian gizzard smooth muscle and liver plasma membranes: a comparative study.Archives of biochemistry and biophysics, , 362 (1 ) ,46-58 More Information

Hurt, R D; Dale, L C; Fredrickson, P A; Caldwell, C C; Lee, G A; Offord, K P; Lauger, G G; Mar?si?, Z; Neese, L W; Lundberg, T G (1994. ) Nicotine patch therapy for smoking cessation combined with physician advice and nurse follow-up. One-year outcome and percentage of nicotine replacement. JAMA, , 271 (8 ) ,595-600

Myers, T F; Patrinos, M E; Muraskas, J; Caldwell, C C; Lambert, G H; Anderson, C L (1987. ) Dynamic trend monitoring of cerebral blood flow velocity in newborn infants. The Journal of pediatrics, , 110 (4 ) ,611-6

Caldwell, C C; Hurley, R M; Anderson, C L; Ahmed, G S; Myers, T F (1985. ) Nonimmune hydrops fetalis managed with peritoneal dialysis.American journal of perinatology, , 2 (3 ) ,211-3 More Information

Caldwell, C C; Stankiewicz, J; Anderson, C L; Ahmed, G S; Myers, T F (1985. ) Intubation-related tracheal stenosis in very-low-birth-weight infants. Diagnosis and treatment. American journal of diseases of children (1960), , 139 (6 ) ,618-20

Puczynski, M S; Dvonch, V M; Menendez, C E; Caldwell, C C (1984. ) Osteomyelitis of the great toe secondary to phlebotomy. Clinical orthopaedics and related research, , (190 ) ,239-40

Anderson, C L; Collin, M F; O'Keefe, J P; Challapalli, M; Myers, T F; Caldwell, C C; Ahmed, G S (1984. ) A widespread epidemic of mild necrotizing enterocolitis of unknown cause. American journal of diseases of children (1960), , 138 (10 ) ,979-83

Caldwell, C C; Levkoff, A H; Purohit, D M (1977. ) Paroxysmal supraventricular tachycardia in a neonate: a complication of racemic epinephrine inhalation for post-extubation stridor. Clinical pediatrics, , 16 (6 ) ,579-80

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Rice, Teresa C; Seitz, Aaron P; Edwards, Michael J; Gulbins, Erich; Caldwell, Charles C (2016. ) Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infection.Journal of leukocyte biology, , More Information

Kuethe, Joshua W; Armocida, Stephanie M; Midura, Emily F; Rice, Teresa C; Hildeman, David A; Healy, Daniel P; Caldwell, Charles C (2016. ) Fecal Microbiota Transplant Restores Mucosal Integrity in a Murine Model of Burn Injury.Shock (Augusta, Ga.), , 45 (6 ) ,647-52 More Information

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Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2016. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, , More Information

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Hoehn, Richard S; Jernigan, Peter L; Chang, Alex L; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Pritts, Timothy A (2016. ) Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 39 (1 ) ,331-40 More Information

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Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang (2015. ) Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.Scientific reports, , 5 ,13721 More Information

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. (03-01-2020. ) Fibrotic liver has prompt recovery after ischemia-reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 318 (3 ) ,G390-G400 More Information

Kim Y.;Goodman M.;Jung A.;Abplanalp W.;Schuster R.;Caldwell C.;Lentsch A.;Pritts T. (01-01-2020. ) Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via.Thrombosis Research, , 185 ,160-166 More Information

Hefele F.;Ditsch A.;Krysiak N.;Caldwell C.;Biberthaler P.;van Griensven M.;Huber-Wagner S.;Hanschen M. (10-11-2019. ) Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Plate.Frontiers in Immunology, , 10 , More Information

Seitz A.P.;Schumacher F.;Baker J.;Soddemann M.;Wilker B.;Caldwell C.C.;Gobble R.M.;Kamler M.;Becker K.A.;Beck S.;Kleuser B.;Edwards M.J.;Gulbins E. (08-01-2019. ) Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia.Journal of Molecular Medicine, , 97 (8 ) ,1195-1211 More Information

Crouser E.;Caldwell C.;Hotchkiss R. (05-01-2019. ) What Is the Skinny on Obesity during Sepsis?.Critical Care Medicine, , 47 (5 ) ,735-736 More Information

Winer L.;Beckmann N.;Veile R.;Goodman M.;Caldwell C.;Nomellini V. (05-01-2019. ) Consumptive coagulopathy is associated with organ dysfunction during PICS.American Journal of Physiology - Lung Cellular and Molecular Physiology, , 316 (5 ) ,L946-L952 More Information

Martin G.E.;Pugh A.M.;Moran R.;Veile R.;Friend L.A.;Pritts T.A.;Makley A.T.;Caldwell C.C.;Goodman M.D. (04-01-2019. ) Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine d.Journal of Trauma and Acute Care Surgery, , 86 (4 ) ,592-599 More Information

Xia B.T.;Beckmann N.;Winer L.K.;Kim Y.;Goetzman H.S.;Veile R.E.;Gulbins E.;Goodman M.D.;Nomellini V.;Caldwell C.C. (03-01-2019. ) Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.Shock, , 51 (3 ) ,356-363 More Information

Konishi T.;Schuster R.M.;Goetzman H.S.;Caldwell C.C.;Lentsch A.B. (01-01-2019. ) Cell-specific regulatory effects of CXCR2 on cholestatic liver injury.American Journal of Physiology - Gastrointestinal and Liver Physiology, , 317 (6 ) ,G773-G783 More Information

Xia B.;Beckmann N.;Winer L.;Pugh A.;Pritts T.;Nomellini V.;Gulbins E.;Caldwell C. (01-01-2019. ) Amitriptyline reduces inflammation and mortality in a murine model of sepsis.Cellular Physiology and Biochemistry, , 52 (3 ) ,565-579 More Information

Gulbins A.;Schumacher F.;Becker K.;Wilker B.;Soddemann M.;Boldrin F.;Müller C.;Edwards M.;Goodman M.;Caldwell C.;Kleuser B.;Kornhuber J.;Szabo I.;Gulbins E. (12-01-2018. ) Antidepressants regulate autophagy by targeting acid sphingomyelinase.Molecular Psychiatry, , 23 (12 ) ,2251 More Information

Gulbins A.;Schumacher F.;Becker K.;Wilker B.;Soddemann M.;Boldrin F.;Müller C.;Edwards M.;Goodman M.;Caldwell C.;Kleuser B.;Kornhuber J.;Szabo I.;Gulbins E. (12-01-2018. ) Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide.Molecular Psychiatry, , 23 (12 ) ,2324-2346 More Information

Baker J.;Boudreau R.;Seitz A.;Caldwell C.;Gulbins E.;Edwards M. (11-01-2018. ) Sphingolipids and innate immunity: A new approach to infection in the post-antibiotic era?.Surgical Infections, , 19 (8 ) ,792-803 More Information

Beckmann N.;Pugh A.;Caldwell C. (10-01-2018. ) Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression.PLoS ONE, , 13 (10 ) , More Information

Keitsch S.;Riethmüller J.;Soddemann M.;Sehl C.;Wilker B.;Edwards M.;Caldwell C.;Fraunholz M.;Gulbins E.;Becker K. (09-25-2018. ) Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-Toxi.Biological Chemistry, , 399 (10 ) ,1203-1213 More Information

Becker K.A.;Riethmüller J.;Seitz A.P.;Gardner A.;Boudreau R.;Kamler M.;Kleuser B.;Schuchman E.;Caldwell C.C.;Edwards M.J.;Grassmé H.;Brodlie M.;Gulbins E. (08-01-2018. ) Sphingolipids as targets for inhalation treatment of cystic fibrosis.Advanced Drug Delivery Reviews, , 133 ,66-75 More Information

Mu X.;Wang X.;Huang W.;Wang R.;Essandoh K.;Li Y.;Pugh A.;Peng J.;Deng S.;Wang Y.;Caldwell C.;Peng T.;Yu K.;Fan G. (04-01-2018. ) Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promo.Shock, , 49 (4 ) ,429-441 More Information

Kim Y.;Abplanalp W.;Jung A.;Schuster R.;Lentsch A.;Gulbins E.;Caldwell C.;Pritts T. (03-01-2018. ) Endocytosis of red blood cell microparticles by pulmonary endothelial cells is mediated by Rab5.Shock, , 49 (3 ) ,288-294 More Information

Kim Y.;Xia B.;Jung A.;Chang A.;Abplanalp W.;Caldwell C.;Goodman M.;Pritts T. (02-01-2018. ) Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of tran.Surgery (United States), , 163 (2 ) ,423-429 More Information

Nomellini V.;Kaplan L.;Sims C.;Caldwell C. (01-01-2018. ) Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, S.Shock, , 49 (1 ) ,4-14 More Information

Martin G.;Xia B.;Kim Y.;Johnson M.;Veile R.;Friend L.;Makley A.;Caldwell C.;Goodman M. (01-01-2018. ) Platelet function changes in a time-dependent manner following traumatic brain injury in a murine mo.Shock, , 50 (5 ) ,551-556 More Information

Becker K.;Fahsel B.;Kemper H.;Mayeres J.;Li C.;Wilker B.;Keitsch S.;Soddemann M.;Sehl C.;Kohnen M.;Edwards M.;Grassmé H.;Caldwell C.;Seitz A.;Fraunholz M.;Gulbins E. (01-01-2018. ) Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinas.Infection and Immunity, , 86 (1 ) , More Information

Ma J.;Gulbins E.;Edwards M.;Caldwell C.;Fraunholz M.;Becker K. (12-01-2017. ) Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and.Cellular Physiology and Biochemistry, , 43 (6 ) ,2170-2184 More Information

Kunz N.;Hauenschild E.;Maass S.;Kalies K.U.;Klinger M.;Barra M.;Hecht L.;Helbig F.;Soellner S.;Caldwell C.C.;Ludwig R.J.;Westermann J.;Kalies K. (12-01-2017. ) Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and .Experimental Dermatology, , 26 (12 ) ,1199-1206 More Information

Rice T.;Pugh A.;Seitz A.;Gulbins E.;Nomellini V.;Caldwell C. (11-01-2017. ) Sphingosine rescues aged mice from pulmonary pseudomonas infection.Journal of Surgical Research, , 219 ,354-359 More Information

Becker K.;Li X.;Seitz A.;Steinmann J.;Koch A.;Schuchman E.;Kamler M.;Edwards M.;Caldwell C.;Gulbins E. (11-01-2017. ) Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine.Cellular Physiology and Biochemistry, , 43 (4 ) ,1603-1616 More Information

Rice T.;Pugh A.;Xia B.;Seitz A.;Whitacre B.;Gulbins E.;Caldwell C. (10-01-2017. ) Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection.Journal of the American College of Surgeons, , 225 (4 ) ,538-547 More Information

Johnson B.L.;Midura E.F.;Prakash P.S.;Rice T.C.;Kunz N.;Kalies K.;Caldwell C.C. (10-01-2017. ) Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a muri.Biochimica et Biophysica Acta - Molecular Basis of Disease, , 1863 (10 ) ,2554-2563 More Information

Martin G.;Boudreau R.;Couch C.;Becker K.;Edwards M.;Caldwell C.;Gulbins E.;Seitz A. (10-01-2017. ) Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic.Biochimie, , 141 ,91-96 More Information

Rice T.;Pugh A.;Caldwell C.;Schneider B. (09-01-2017. ) Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in.Critical Care Nursing Clinics of North America, , 29 (3 ) ,331-340 More Information

Kunz N.;Xia B.T.;Kalies K.U.;Klinger M.;Gemoll T.;Habermann J.K.;Whitacre B.E.;Seitz A.P.;Kalies K.;Caldwell C.C. (09-01-2017. ) Cell-Derived Nanoparticles are Endogenous Modulators of Sepsis with Therapeutic Potential.Shock, , 48 (3 ) ,346-354 More Information

Pugh A.;Auteri N.;Goetzman H.;Caldwell C.;Nomellini V. (08-10-2017. ) A murine model of persistent inflammation, immune suppression, and catabolism syndrome.International Journal of Molecular Sciences, , 18 (8 ) , More Information

Boudreau R.M.;Johnson M.;Veile R.;Friend L.A.;Goetzman H.;Caldwell C.C.;Makley A.T.;Goodman M.D. (07-01-2017. ) Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury.Journal of Surgical Research, , 215 ,47-54 More Information

Grassmé H.;Henry B.;Ziobro R.;Becker K.A.;Riethmüller J.;Gardner A.;Seitz A.P.;Steinmann J.;Lang S.;Ward C.;Schuchman E.H.;Caldwell C.C.;Kamler M.;Edwards M.J.;Brodlie M.;Gulbins E. (06-14-2017. ) ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingo.Cell Host and Microbe, , 21 (6 ) ,707-718.e8 More Information

Rice T.;Armocida S.;Kuethe J.;Midura E.;Jain A.;Hildeman D.;Healy D.;Gulbins E.;Caldwell C. (03-01-2017. ) Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.Cellular Immunology, , 313 ,25-31 More Information

Hoehn R.;Jernigan P.;Japtok L.;Chang A.;Midura E.;Caldwell C.;Kleuser B.;Lentsch A.;Edwards M.;Gulbins E.;Pritts T. (01-01-2017. ) Acid sphingomyelinase inhibition in stored erythrocytes reduces transfusion-associated lung inflamma.Annals of Surgery, , 265 (1 ) ,218-226 More Information

Lehmann C.;Burkovskiy I.;Kuethe J.;Zhou J.;Caldwell C.;Kelly M. (01-01-2014. ) Inhibition of the cannabinoid 2 receptor in CNS-injury induced immunodeficiency syndrome.Medical Hypotheses, , 82 (6 ) ,736-739 More Information

Siegmann N.;Worbs D.;Effinger F.;Bormann T.;Gebhardt M.;Ulrich M.;Wermeling F.;Müller-Hermelink E.;Biedermann T.;Tighe M.;Edwards M.;Caldwell C.;Leadbetter E.;Karlsson M.;Becker K.;Gulbins E.;Döring G. (01-01-2014. ) Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in c.Cellular Physiology and Biochemistry, , 34 (1 ) ,56-70 More Information

Caldwell C.C.;Chen Y.;Goetzmann H.S.;Hao Y.;Borchers M.T.;Hassett D.J.;Young L.R.;Mavrodi D.;Thomashow L.;Lau G.W. (01-01-2009. ) Pseudomonas aeruginosa exotoxin pyocyanin causes cystic fibrosis airway pathogenesis.American Journal of Pathology, , 175 (6 ) ,2473-2488 More Information

Nogueiras R.;Veyrat-Durebex C.;Suchanek P.M.;Klein M.;Tschöp J.;Caldwell C.;Woods S.C.;Wittmann G.;Watanabe M.;Liposits Z.;Fekete C.;Reizes O.;Rohner-Jeanrenaud F.;Tschöp M.H. (01-01-2008. ) Peripheral, but Not Central, CB1 antagonism provides food intake-independent metabolic benefits in d.Diabetes, , 57 (11 ) ,2977-2991 More Information

Shivakumar P.;Sabla G.;Mohanty S.;McNeal M.;Ward R.;Stringer K.;Caldwell C.;Chougnet C.;Bezerra J. (01-01-2007. ) Effector Role of Neonatal Hepatic CD8+ Lymphocytes in Epithelial Injury and A.Gastroenterology, , 133 (1 ) ,268-277 More Information

Thiel M.;Chouker A.;Ohta A.;Jackson E.;Caldwell C.;Smith P.;Lukashev D.;Bittmann I.;Sitkovsky M. (06-01-2005. ) Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inf.PLoS Biology, , 3 (6 ) ,1088-1100 More Information

Sitkovsky M.;Lukashev D.;Apasov S.;Kojima H.;Koshiba M.;Caldwell C.;Ohta A.;Thiel M. (06-07-2004. ) Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors.Annual Review of Immunology, , 22 ,657-682 More Information

Lukashev D.;Caldwell C.;Ohta A.;Chen P.;Sitkovsky M. (12-28-2001. ) Differential Regulation of Two Alternatively Spliced Isoforms of Hypoxia-inducible Factor-1? in Acti.Journal of Biological Chemistry, , 276 (52 ) ,48754-48763 More Information

Armstrong J.M.;Chen J.F.;Schwarzschild M.A.;Apasov S.;Smith P.T.;Caldwell C.;Chen P.;Figler H.;Sullivan G.;Fink S.;Linden J.;Sitkovsky M. (02-15-2001. ) Gene dose effect reveals GS-coupled A2A adenosine rece.Biochemical Journal, , 354 (1 ) ,123-130 More Information

Caldwell C.;Hornyak S.;Stephen Dahms A. (12-01-1998. ) Probes at the chicken smooth muscle ECTO-ATPASE: A comprehensive regulatory model .FASEB Journal, , 12 (8 ) ,

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Remy, Kenneth E; Mazer, Monty; Striker, David A; Ellebedy, Ali H; Walton, Andrew H; Unsinger, Jacqueline; Blood, Teresa M; Mudd, Philip A; Yi, Daehan J; Mannion, Daniel A; Osborne, Dale F; Martin, R Scott; Anand, Nitin J; Bosanquet, James P; Blood, Jane; Drewry, Anne M; Caldwell, Charles C; Turnbull, Isaiah R; Brakenridge, Scott C; Moldawer, Lyle L; Hotchkiss, Richard S (2020. ) Severe immunosuppression and not a cytokine storm characterize COVID-19 infections.JCI insight, , More Information

Pulliam, Kasiemobi E; Joseph, Bernadin; Veile, Rosalie A; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Lentsch, Alex B; Goodman, Michael D; Pritts, Timothy A (2020. ) SAVE IT - DON'T WASTE IT! MAXIMIZING UTILIZATION OF ERYTHROCYTES FROM PREVIOUSLY STORED WHOLE BLOOD.The journal of trauma and acute care surgery, , More Information

Salyer, Christen E; Bomholt, Christina; Beckmann, Nadine; Bergmann, Christian B; Plattner, Courtney A; Caldwell, Charles C (2020. ) Novel Therapeutics for the Treatment of Burn Infection.Surgical infections, , More Information

Sengupta, Satarupa; Caldwell, Charles C; Nomellini, Vanessa (2020. ) Distinct Neutrophil Populations in the Spleen During PICS.Frontiers in immunology, , 11 ,804 More Information

Beckmann, Nadine; Huber, Franziska; Hanschen, Marc; St Pierre Schneider, Barbara; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Scald Injury-Induced T Cell Dysfunction Can Be Mitigated by Gr1+ Cell Depletion and Blockage of CD47/CD172a Signaling.Frontiers in immunology, , 11 ,876 More Information

Beckmann, Nadine; Sutton, Jeffrey M; Hoehn, Richard S; Jernigan, Peter L; Friend, Lou Ann; Johanningman, Taylor A; Schuster, Rebecca M; Lentsch, Alex B; Caldwell, Charles C; Pritts, Timothy A (2020. ) IFN? and TNF? mediate CCL22/MDC production in alveolar macrophages after hemorrhage and resuscitation.American journal of physiology. Lung cellular and molecular physiology, , 318 (5 ) ,L864-L872 More Information

Beckmann, Nadine; Salyer, Christen E; Crisologo, Peter A; Nomellini, Vanessa; Caldwell, Charles C (2020. ) Staging and Personalized Intervention for Infection and Sepsis.Surgical infections, , More Information

Konishi, Takanori; Schuster, Rebecca M; Goetzman, Holly S; Caldwell, Charles C; Lentsch, Alex B (2020. ) Fibrotic liver has prompt recovery after ischemia-reperfusion injury.American journal of physiology. Gastrointestinal and liver physiology, , 318 (3 ) ,G390-G400 More Information

Kim, Young; Goodman, Michael D; Jung, Andrew D; Abplanalp, William A; Schuster, Rebecca M; Caldwell, Charles C; Lentsch, Alex B; Pritts, Timothy A (2020. ) Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via P-selectin.Thrombosis research, , 185 ,160-166 More Information

Konishi, Takanori; Schuster, Rebecca M; Goetzman, Holly S; Caldwell, Charles C; Lentsch, Alex B (2019. ) Cell-specific regulatory effects of CXCR2 on cholestatic liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 317 (6 ) ,G773-G783 More Information

Hefele, Friederike; Ditsch, Alexander; Krysiak, Niels; Caldwell, Charles C; Biberthaler, Peter; van Griensven, Martijn; Huber-Wagner, Stefan; Hanschen, Marc (2019. ) Trauma Induces Interleukin-17A Expression on Th17 Cells and CD4+ Regulatory T Cells as Well as Platelet Dysfunction.Frontiers in immunology, , 10 ,2389 More Information

Seitz, Aaron P; Schumacher, Fabian; Baker, Jennifer; Soddemann, Matthias; Wilker, Barbara; Caldwell, Charles C; Gobble, Ryan M; Kamler, Markus; Becker, Katrin Anne; Beck, Sascha; Kleuser, Burkhard; Edwards, Michael J; Gulbins, Erich (2019. ) Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumonia.Journal of molecular medicine (Berlin, Germany), , 97 (8 ) ,1195-1211 More Information

Winer, Leah K; Beckmann, Nadine; Veile, Rosalie A; Goodman, Michael D; Caldwell, Charles C; Nomellini, Vanessa (2019. ) Consumptive coagulopathy is associated with organ dysfunction during PICS.American journal of physiology. Lung cellular and molecular physiology, , 316 (5 ) ,L946-L952 More Information

Crouser, Elliott D; Caldwell, Charles C; Hotchkiss, Richard S (2019. ) What Is the Skinny on Obesity During Sepsis?.Critical care medicine, , 47 (5 ) ,735-736 More Information

Martin, Grace E; Pugh, Amanda M; Moran, Ryan; Veile, Rose; Friend, Lou Ann; Pritts, Timothy A; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D (2019. ) Microvesicles generated following traumatic brain injury induce platelet dysfunction via adenosine diphosphate receptor.The journal of trauma and acute care surgery, , 86 (4 ) ,592-600 More Information

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Kim, Young; Goetzman, Holly S; Veile, Rosalie E; Gulbins, Erich; Goodman, Michael D; Nomellini, Vanessa; Caldwell, Charles C (2019. ) Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy.Shock (Augusta, Ga.), , 51 (3 ) ,356-363 More Information

Xia, Brent T; Beckmann, Nadine; Winer, Leah K; Pugh, Amanda M; Pritts, Timothy A; Nomellini, Vanessa; Gulbins, Erich; Caldwell, Charles C (2019. ) Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 52 (3 ) ,565-579 More Information

Gulbins, Anne; Schumacher, Fabian; Becker, Katrin Anne; Wilker, Barbara; Soddemann, Matthias; Boldrin, Francesco; Müller, Christian P; Edwards, Michael J; Goodman, Michael; Caldwell, Charles C; Kleuser, Burkhard; Kornhuber, Johannes; Szabo, Ildiko; Gulbins, Erich (2018. ) Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.Molecular psychiatry, , 23 (12 ) ,2324-2346 More Information

Martin, Grace E; Xia, Brent; Kim, Young; Johnson, Mark D; Veile, Rosalie; Friend, Lou Ann; Makley, Amy T; Caldwell, Charles C; Goodman, Michael D (2018. ) Platelet Function Changes in a Time-Dependent Manner Following Traumatic Brain Injury in a Murine Model.Shock (Augusta, Ga.), , 50 (5 ) ,551-556 More Information

Baker, Jennifer E; Boudreau, Ryan M; Seitz, Aaron P; Caldwell, Charles C; Gulbins, Erich; Edwards, Michael J Sphingolipids and Innate Immunity: A New Approach to Infection in the Post-Antibiotic Era?.Surgical infections, , 19 (8 ) ,792-803 More Information

Beckmann, Nadine; Pugh, Amanda M; Caldwell, Charles C (2018. ) Burn injury alters the intestinal microbiome's taxonomic composition and functional gene expression.PloS one, , 13 (10 ) ,e0205307 More Information

Keitsch, Simone; Riethmüller, Joachim; Soddemann, Matthias; Sehl, Carolin; Wilker, Barbara; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Gulbins, Erich; Becker, Katrin Anne (2018. ) Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of ?-toxin.Biological chemistry, , 399 (10 ) ,1203-1213 More Information

Becker, Katrin Anne; Riethmüller, Joachim; Seitz, Aaron P; Gardner, Aaron; Boudreau, Ryan; Kamler, Markus; Kleuser, Burkhard; Schuchman, Edward; Caldwell, Charles C; Edwards, Michael J; Grassmé, Heike; Brodlie, Malcolm; Gulbins, Erich (2018. ) Sphingolipids as targets for inhalation treatment of cystic fibrosis.Advanced drug delivery reviews, , 133 ,66-75 More Information

Mu, Xingjiang; Wang, Xiaohong; Huang, Wei; Wang, Rui-Tao; Essandoh, Kobina; Li, Yutian; Pugh, Amanda M; Peng, Jiangtong; Deng, Shan; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Yu, Kai-Jiang; Fan, Guo-Chang (2018. ) Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation.Shock (Augusta, Ga.), , 49 (4 ) ,429-441 More Information

Kim, Young; Abplanalp, William A; Jung, Andrew D; Schuster, Rebecca M; Lentsch, Alex B; Gulbins, Erich; Caldwell, Charles C; Pritts, Timothy A (2018. ) Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5.Shock (Augusta, Ga.), , 49 (3 ) ,288-294 More Information

Kim, Young; Xia, Brent T; Jung, Andrew D; Chang, Alex L; Abplanalp, William A; Caldwell, Charles C; Goodman, Michael D; Pritts, Timothy A (2018. ) Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion.Surgery, , 163 (2 ) ,423-429 More Information

Nomellini, Vanessa; Kaplan, Lewis J; Sims, Carrie A; Caldwell, Charles C (2018. ) Chronic Critical Illness and Persistent Inflammation: What can we Learn from the Elderly, Injured, Septic, and Malnourished?.Shock (Augusta, Ga.), , 49 (1 ) ,4-14 More Information

Becker, Katrin Anne; Fahsel, Björn; Kemper, Hannes; Mayeres, Joelina; Li, Cao; Wilker, Barbara; Keitsch, Simone; Soddemann, Matthias; Sehl, Carolin; Kohnen, Marcus; Edwards, Michael J; Grassmé, Heike; Caldwell, Charles C; Seitz, Aaron; Fraunholz, Martin; Gulbins, Erich (2018. ) Staphylococcus aureus Alpha-Toxin Disrupts Endothelial-Cell Tight Junctions via Acid Sphingomyelinase and Ceramide.Infection and immunity, , 86 (1 ) , More Information

Kunz, Natalia; Hauenschild, Eva; Maass, Sebastian; Kalies, Kai-Uwe; Klinger, Matthias; Barra, Melanie; Hecht, Lars; Helbig, Franz; Soellner, Stefan; Caldwell, Charles C; Ludwig, Ralf J; Westermann, Jürgen; Kalies, Kathrin (2017. ) Nanoparticles prepared from porcine cells support the healing of cutaneous inflammation in mice and wound re-epithelialization in human skin.Experimental dermatology, , 26 (12 ) ,1199-1206 More Information

Rice, Teresa C; Pugh, Amanda M; Seitz, Aaron P; Gulbins, Erich; Nomellini, Vanessa; Caldwell, Charles C (2017. ) Sphingosine rescues aged mice from pulmonary pseudomonas infection.The Journal of surgical research, , 219 ,354-359 More Information

Johnson, Bobby L; Midura, Emily F; Prakash, Priya S; Rice, Teresa C; Kunz, Natalia; Kalies, Kathrin; Caldwell, Charles C (2017. ) Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a murine model of sepsis.Biochimica et biophysica acta. Molecular basis of disease, , 1863 (10 Pt B ) ,2554-2563 More Information

Martin, Grace E; Boudreau, Ryan M; Couch, Caroline; Becker, Katrin Anne; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Seitz, Aaron (2017. ) Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic.Biochimie, , 141 ,91-96 More Information

Rice, Teresa C; Pugh, Amanda M; Xia, Brent T; Seitz, Aaron P; Whitacre, Brynne E; Gulbins, Erich; Caldwell, Charles C (2017. ) Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary Infection.Journal of the American College of Surgeons, , 225 (4 ) ,538-547 More Information

Rice, Teresa C; Pugh, Amanda M; Caldwell, Charles C; Schneider, Barbara St Pierre (2017. ) Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in Sepsis.Critical care nursing clinics of North America, , 29 (3 ) ,331-340 More Information

Kunz, Natalia; Xia, Brent T; Kalies, Kai-Uwe; Klinger, Matthias; Gemoll, Timo; Habermann, Jens K; Whitacre, Brynne E; Seitz, Aaron P; Kalies, Kathrin; Caldwell, Charles C (2017. ) Cell-Derived Nanoparticles are Endogenous Modulators of Sepsis With Therapeutic Potential.Shock (Augusta, Ga.), , 48 (3 ) ,346-354 More Information

Pugh, Amanda M; Auteri, Nicholas J; Goetzman, Holly S; Caldwell, Charles C; Nomellini, Vanessa (2017. ) A Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome.International journal of molecular sciences, , 18 (8 ) , More Information

Boudreau, Ryan M; Johnson, Mark; Veile, Rosalie; Friend, Lou Ann; Goetzman, Holly; Pritts, Timothy A; Caldwell, Charles C; Makley, Amy T; Goodman, Michael D (2017. ) Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury and hemorrhage.The Journal of surgical research, , 215 ,47-54 More Information

Grassmé, Heike; Henry, Brian; Ziobro, Regan; Becker, Katrin Anne; Riethmüller, Joachim; Gardner, Aaron; Seitz, Aaron P; Steinmann, Joerg; Lang, Stephan; Ward, Christopher; Schuchman, Edward H; Caldwell, Charles C; Kamler, Markus; Edwards, Michael J; Brodlie, Malcolm; Gulbins, Erich (2017. ) ?1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial Infections.Cell host & microbe, , 21 (6 ) ,707-718.e8 More Information

Rice, Teresa C; Armocida, Stephanie M; Kuethe, Joshua W; Midura, Emily F; Jain, Ayushi; Hildeman, David A; Healy, Daniel P; Gulbins, Erich; Caldwell, Charles C (2017. ) Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.Cellular immunology, , 313 ,25-31 More Information

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2017. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, , 265 (1 ) ,218-226 More Information

Ma, Jie; Gulbins, Erich; Edwards, Michael J; Caldwell, Charles C; Fraunholz, Martin; Becker, Katrin Anne (2017. ) Staphylococcus aureus ?-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and Ceramides.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 43 (6 ) ,2170-2184 More Information

Becker, Katrin Anne; Li, Xiang; Seitz, Aaron; Steinmann, Joerg; Koch, Anne; Schuchman, Edward; Kamler, Markus; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich (2017. ) Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by Sphingosine.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 43 (4 ) ,1603-1616 More Information

Contact Information

Academic - Medical Sciences Building
SRU Room G479
Cincinnati  Ohio, 45267
Phone: 513-558-1974
charles.caldwell@uc.edu