Kenneth Campbell , PhD

Molecular and cellular mechanisms of patterning and differentiation in the vertebrate forebrain.

Doctoral Degree: University of Lund 1994 ( )

The Campbell lab is working to uncover the molecular genetic mechanisms that control the normal formation of basal ganglia circuits. By disrupting or augmenting these circuits they learn how normal behaviors are altered. This knowledge will help generate mouse models of certain behaviors that characterize childhood neuropsychiatric disorders and pave the way for the development of improved therapeutics.

Peer Reviewed Publications

Ehrman, Jacqueline M; Merchan-Sala, Paloma; Ehrman, Lisa A; Chen, Bin; Lim, Hee-Woong; Waclaw, Ronald R; Campbell, Kenneth (2022. ) Formation of the Mouse Internal Capsule and Cerebral Peduncle: A Pioneering Role for Striatonigral Axons as Revealed in Isl1 Conditional Mutants.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 42 (16 ) ,3344-3364 More Information

Iwasawa, Eri; Brown, Farrah N; Shula, Crystal; Kahn, Fatima; Lee, Sang Hoon; Berta, Temugin; Ladle, David R; Campbell, Kenneth; Mangano, Francesco T; Goto, June (2022. ) The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 42 (9 ) ,1820-1844 More Information

Del Águila, Ángela; Adam, Mike; Ullom, Kristy; Shaw, Nicholas; Qin, Shenyue; Ehrman, Jacqueline; Nardini, Diana; Salomone, Joseph; Gebelein, Brian; Lu, Q Richard; Potter, Steven S; Waclaw, Ronald; Campbell, Kenneth; Nakafuku, Masato (2022. ) Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.Development (Cambridge, England), , 149 (5 ) , More Information

Zoubovsky, Sandra P; Williams, Michael T; Hoseus, Sarah; Tumukuntala, Shivani; Riesenberg, Amy; Schulkin, Jay; Vorhees, Charles V; Campbell, Kenneth; Lim, Hee-Woong; Muglia, Louis J (2022. ) Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment.Translational psychiatry, , 12 (1 ) ,22 More Information

Salomone, Joseph; Qin, Shenyue; Fufa, Temesgen D; Cain, Brittany; Farrow, Edward; Guan, Bin; Hufnagel, Robert B; Nakafuku, Masato; Lim, Hee-Woong; Campbell, Kenneth; Gebelein, Brian (2021. ) Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice.Genes & development, , 35 (1-2 ) ,157-174 More Information

Roychoudhury, Kaushik; Salomone, Joseph; Qin, Shenyue; Cain, Brittany; Adam, Mike; Potter, S Steven; Nakafuku, Masato; Gebelein, Brian; Campbell, Kenneth (2020. ) Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence.Development (Cambridge, England), , 147 (7 ) , More Information

Scheimann, Jessie R; Mahbod, Parinaz; Morano, Rachel; Frantz, Lindsey; Packard, Ben; Campbell, Kenneth; Herman, James P (2018. ) Deletion of Glucocorticoid Receptors in Forebrain GABAergic Neurons Alters Acute Stress Responding and Passive Avoidance Behavior in Female Mice.Frontiers in behavioral neuroscience, , 12 ,325 More Information

Tinterri, Andrea; Menardy, Fabien; Diana, Marco A; Lokmane, Ludmilla; Keita, Maryama; Coulpier, Fanny; Lemoine, Sophie; Mailhes, Caroline; Mathieu, Benjamin; Merchan-Sala, Paloma; Campbell, Kenneth; Gyory, Ildiko; Grosschedl, Rudolf; Popa, Daniela; Garel, Sonia (2018. ) Active intermixing of indirect and direct neurons builds the striatal mosaic.Nature communications, , 9 (1 ) ,4725 More Information

Desmaris, Elodie; Keruzore, Marc; Saulnier, Amandine; Ratié, Leslie; Assimacopoulos, Stavroula; De Clercq, Sarah; Nan, Xinsheng; Roychoudhury, Kaushik; Qin, Shenyue; Kricha, Sadia; Chevalier, Clément; Lingner, Thomas; Henningfeld, Kristine A; Zarkower, David; Mallamaci, Antonello; Theil, Thomas; Campbell, Kenneth; Pieler, Tomas; Li, Meng; Grove, Elizabeth A; Bellefroid, Eric J (2018. ) DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 38 (42 ) ,9105-9121 More Information

Chapman, Heather; Riesenberg, Amy; Ehrman, Lisa A; Kohli, Vikram; Nardini, Diana; Nakafuku, Masato; Campbell, Kenneth; Waclaw, Ronald R (2018. ) Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence.Developmental biology, , 442 (1 ) ,115-126 More Information

Li, Jiwen; Wang, Chunyang; Zhang, Zhuangzhi; Wen, Yan; An, Lei; Liang, Qifei; Xu, Zhejun; Wei, Song; Li, Weiwei; Guo, Teng; Liu, Guoping; Tao, Guangxu; You, Yan; Du, Heng; Fu, Zhuoning; He, Miao; Chen, Bin; Campbell, Kenneth; Alvarez-Buylla, Arturo; Rubenstein, John L; Yang, Zhengang (2018. ) Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.Cerebral cortex (New York, N.Y. : 1991), , 28 (9 ) ,3278-3294 More Information

Kuerbitz, Jeffrey; Arnett, Melinda; Ehrman, Sarah; Williams, Michael T; Vorhees, Charles V; Fisher, Simon E; Garratt, Alistair N; Muglia, Louis J; Waclaw, Ronald R; Campbell, Kenneth (2018. ) Loss of Intercalated Cells (ITCs) in the Mouse Amygdala of Tshz1 Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 38 (5 ) ,1160-1177 More Information

Abdelhamed, Zakia; Vuong, Shawn M; Hill, Lauren; Shula, Crystal; Timms, Andrew; Beier, David; Campbell, Kenneth; Mangano, Francesco T; Stottmann, Rolf W; Goto, June (2018. ) A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice.Development (Cambridge, England), , 145 (1 ) , More Information

Merchan-Sala, Paloma; Nardini, Diana; Waclaw, Ronald R; Campbell, Kenneth (2017. ) Selective neuronal expression of the SoxE factor, Sox8, in direct pathway striatal projection neurons of the developing mouse brain.The Journal of comparative neurology, , 525 (13 ) ,2805-2819 More Information

Qin, Shenyue; Ware, Stephanie M; Waclaw, Ronald R; Campbell, Kenneth (2017. ) Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.Neural development, , 12 (1 ) ,13 More Information

Qin, Shenyue; Madhavan, Mayur; Waclaw, Ronald R; Nakafuku, Masato; Campbell, Kenneth (2016. ) Characterization of a new Gsx2-cre line in the developing mouse telencephalon.Genesis (New York, N.Y. : 2000), , 54 (10 ) ,542-549 More Information

Dunty, William C; Kennedy, Mark W L; Chalamalasetty, Ravindra B; Campbell, Kenneth; Yamaguchi, Terry P (2014. ) Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/?-catenin pathway in neuromesodermal stem cells.PloS one, , 9 (1 ) ,e87018 More Information

Seto, Yusuke; Nakatani, Tomoya; Masuyama, Norihisa; Taya, Shinichiro; Kumai, Minoru; Minaki, Yasuko; Hamaguchi, Akiko; Inoue, Yukiko U; Inoue, Takayoshi; Miyashita, Satoshi; Fujiyama, Tomoyuki; Yamada, Mayumi; Chapman, Heather; Campbell, Kenneth; Magnuson, Mark A; Wright, Christopher V; Kawaguchi, Yoshiya; Ikenaka, Kazuhiro; Takebayashi, Hirohide; Ishiwata, Shin'ichi; Ono, Yuichi; Hoshino, Mikio (2014. ) Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.Nature communications, , 5 ,3337 More Information

Ehrman, Lisa A; Mu, Xiuqian; Waclaw, Ronald R; Yoshida, Yutaka; Vorhees, Charles V; Klein, William H; Campbell, Kenneth (2013. ) The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.Proceedings of the National Academy of Sciences of the United States of America, , 110 (42 ) ,E4026-35 More Information

Katayama, Kei-ichi; Imai, Fumiyasu; Campbell, Kenneth; Lang, Richard A; Zheng, Yi; Yoshida, Yutaka (2013. ) RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration.Development (Cambridge, England), , 140 (15 ) ,3139-45 More Information

Chapman, Heather; Waclaw, Ronald R; Pei, Zhenglei; Nakafuku, Masato; Campbell, Kenneth (2013. ) The homeobox gene Gsx2 controls the timing of oligodendroglial fate specification in mouse lateral ganglionic eminence progenitors.Development (Cambridge, England), , 140 (11 ) ,2289-98 More Information

López-Juárez, Alejandro; Howard, Jennifer; Ullom, Kristy; Howard, Lindsey; Grande, Andrew; Pardo, Andrea; Waclaw, Ronald; Sun, Yu-Yo; Yang, Dianer; Kuan, Chia-Yi; Campbell, Kenneth; Nakafuku, Masato (2013. ) Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone.Genes & development, , 27 (11 ) ,1272-87 More Information

Grande, Andrew; Sumiyoshi, Kyoko; López-Juárez, Alejandro; Howard, Jennifer; Sakthivel, Bhuvaneswari; Aronow, Bruce; Campbell, Kenneth; Nakafuku, Masato (2013. ) Environmental impact on direct neuronal reprogramming in vivo in the adult brain.Nature communications, , 4 ,2373 More Information

Pei, Zhenglei; Wang, Bei; Chen, Gang; Nagao, Motoshi; Nakafuku, Masato; Campbell, Kenneth (2011. ) Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation.Proceedings of the National Academy of Sciences of the United States of America, , 108 (4 ) ,1675-80 More Information

Carpenter, April C; Rao, Sujata; Wells, James M; Campbell, Kenneth; Lang, Richard A (2010. ) Generation of mice with a conditional null allele for Wntless.Genesis (New York, N.Y. : 2000), , 48 (9 ) ,554-8 More Information

Waclaw, Ronald R; Ehrman, Lisa A; Pierani, Alessandra; Campbell, Kenneth (2010. ) Developmental origin of the neuronal subtypes that comprise the amygdalar fear circuit in the mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (20 ) ,6944-53 More Information

Waclaw, Ronald R; Campbell, Kenneth (2009. ) Regional control of cortical lamination.Nature neuroscience, , 12 (10 ) ,1211-2 More Information

Waclaw, Ronald R; Wang, Bei; Pei, Zhenglei; Ehrman, Lisa A; Campbell, Kenneth (2009. ) Distinct temporal requirements for the homeobox gene Gsx2 in specifying striatal and olfactory bulb neuronal fates.Neuron, , 63 (4 ) ,451-65 More Information

Wang, Bei; Waclaw, Ronald R; Allen, Zegary J; Guillemot, Francois; Campbell, Kenneth (2009. ) Ascl1 is a required downstream effector of Gsx gene function in the embryonic mouse telencephalon.Neural development, , 4 ,5 More Information

Chen, Lei; Melendez, Jaime; Campbell, Kenneth; Kuan, Chia-Yi; Zheng, Yi (2009. ) Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly.Developmental biology, , 325 (1 ) ,162-70 More Information

Nagao, Motoshi; Campbell, Kenneth; Burns, Kevin; Kuan, Chia-Yi; Trumpp, Andreas; Nakafuku, Masato (2008. ) Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathway.The Journal of cell biology, , 183 (7 ) ,1243-57 More Information

Allen, Zegary J; Waclaw, Ronald R; Colbert, Melissa C; Campbell, Kenneth (2007. ) Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes.Journal of molecular histology, , 38 (6 ) ,517-25 More Information

Chen, Lei; Liao, Guanghong; Waclaw, Ronald R; Burns, Kevin A; Linquist, Diana; Campbell, Kenneth; Zheng, Yi; Kuan, Chia-Yi (2007. ) Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 27 (14 ) ,3884-93 More Information

Chen, Lei; Liao, Guanghong; Yang, Linda; Campbell, Kenneth; Nakafuku, Masato; Kuan, Chia-Yi; Zheng, Yi (2006. ) Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.Proceedings of the National Academy of Sciences of the United States of America, , 103 (44 ) ,16520-5 More Information

Waclaw, Ronald R; Allen, Zegary J; Bell, Sheila M; Erdélyi, Ferenc; Szabó, Gábor; Potter, S Steven; Campbell, Kenneth (2006. ) The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons.Neuron, , 49 (4 ) ,503-16 More Information

Campbell, Kenneth (2005. ) Cortical neuron specification: it has its time and place.Neuron, , 46 (3 ) ,373-6 More Information

Waclaw, Ronald R; Wang, Bei; Campbell, Kenneth (2004. ) The homeobox gene Gsh2 is required for retinoid production in the embryonic mouse telencephalon.Development (Cambridge, England), , 131 (16 ) ,4013-20 More Information

Stenman, Jan M; Wang, Bei; Campbell, Kenneth (2003. ) Tlx controls proliferation and patterning of lateral telencephalic progenitor domains. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 23 (33 ) ,10568-76

Bell, Sheila M; Schreiner, Claire M; Waclaw, Ronald R; Campbell, Kenneth; Potter, S Steven; Scott, William J (2003. ) Sp8 is crucial for limb outgrowth and neuropore closure.Proceedings of the National Academy of Sciences of the United States of America, , 100 (21 ) ,12195-200 More Information

Campbell, Kenneth (2003. ) Signaling to and from radial glia.Glia, , 43 (1 ) ,44-6 More Information

Stenman, Jan; Yu, Ruth T; Evans, Ronald M; Campbell, Kenneth (2003. ) Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon.Development (Cambridge, England), , 130 (6 ) ,1113-22 More Information

Campbell, Kenneth (2003. ) Dorsal-ventral patterning in the mammalian telencephalon.Current opinion in neurobiology, , 13 (1 ) ,50-6 More Information

Stenman, Jan; Toresson, Hakan; Campbell, Kenneth (2003. ) Identification of two distinct progenitor populations in the lateral ganglionic eminence: implications for striatal and olfactory bulb neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 23 (1 ) ,167-74

Campbell, Kenneth; Götz, Magdalena (2002. ) Radial glia: multi-purpose cells for vertebrate brain development.Trends in neurosciences, , 25 (5 ) ,235-8 More Information

Academic - Stetson Building
Suite 2200
Cincinnati  Ohio, 45267
Phone: 513-636-0246
Kenneth.Campbell@cchmc.org