Jose A. Cancelas , MD

Dr. Cancelas clinical interests are hematopoiesis (blood cell formation), cell therapies and transfusion medicine. His research into the role of the Rho protein family of GTPases in health and leukemia has clarified the cellular and molecular mechanisms of hematopoietic stem cell (HSC), granulocyte progenitors and platelet survival. His transfusion medicine and cell therapy research works to identify novel methods to preserve red cell, platelet and plasma and generate alternative blood and cell products to cover unmet clinical needs in cancer and trauma. He is internationally recognized for his expertise in stem cell biology and pathogen inactivation of blood and cell therapies.

Dr. Cancelas awards include the AABB David B. Paul Prize for Innovative Research in Transfusion Medicine, Cincinnati Business Courier Healthcare Heroes Innovator Award Winner, and the National Blood Foundation Hall of Fame.

MD : Autonomous University of Madrid Spain , 1989 (Medicine)

Specialist: Hospital Ramon y Cajal Madrid, Spain, 1993 (Hematology and Hemotherapy)

PhD : University of Alcala de Henares Madrid, Spain, 1996 (Medicine/Hematology)

Fellowship: University of Cincinnati Cincinnati, 2003 (Blood Banking & Transfusion Med.)

Pathology

Blood Banking and Transfusion Medicine

Hematology

1. Stem Cell Biology & Hematopoietic Microenvironment
2. Leukemogenesis & Leukemia Therapy
3. Blood & Cell Therapies

Grant: #CerusCorp Investigators:Cancelas-Perez, Jose 09-01-2006 -08-31-2007 Cerus Corporation A Randomized, Single-Blind, Controlled, 2 Period Crossover Study of Red Blood Cells. Role: PI $226,242.87 Active

Grant: #PC387970 Investigators:Cancelas-Perez, Jose 11-01-2006 -03-31-2008 Department of the Army In Vitro Evaluation of the Hemerus LEUKOSEP HWB-600-XL Leukocyte Reduction Filtration System for Whole Blood with CPD Anticoagulant and SOLX Additive Role:PI $138,594.83 Active Level:Federal

Grant: #SRS 00561 Investigators:Cancelas-Perez, Jose 01-01-2007 -12-31-2007 Novartis AG Pilot in Vitro Storage Study for Full Units of ECO RBC Prepared with Zeke-2 Role:PI $95,079.00 Active Level:Industry

Grant: #SRS 000562 Investigators:Cancelas-Perez, Jose 12-01-2006 -11-30-2007 Maco Productions In-Vivo Study of the MacoPharma Leukoreduction Systems for Whole Blood (Leukoflex MTL1) As Used For the Preparation of Whole Blood Role:PI $73,246.64 Active Level:Foreign Industry

Grant: #FCRP-0706 Investigators:Cancelas-Perez, Jose 01-01-2007 -12-31-2007 Baxter Healthcare Corporation Evaluation of a Platelet Aliquot Set Using TRIMA Platelets Role:PI $75,259.00 Active Level:Industry

Investigators:Cancelas-Perez, Jose 01-01-2005 -12-31-2005 Hemerus Medical, LLC In Vitro Evaluation of Leukosep Leukosep Leukocyte Reduction Filtration System Role:PI $63,394.00 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 05-27-2005 -05-26-2006 Hemerus Medical, LLC In Vivo and In Vitro Evaluation of LeukoSep HRC-600-C Leukocyte Reduction Filtration System for Red Cells Role:PI $74,170.96 Closed Level:Industry

Grant: #Supplement #5 Investigators:Cancelas-Perez, Jose 12-01-2005 -06-30-2007 Gambro AB Evaluation of the Trima System's Predicted Post-Procedure Platelet Count Role:PI $44,049.00 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 02-01-2006 -01-31-2007 Hemerus Medical, LLC In Vitro Evaluation of LeukoSep HRC-600-C Leukocyte Reduction Filtration System for Red Cells Role:PI $187,817.00 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 04-01-2006 -03-31-2007 ZymeQuest, Inc. Evaluation of the Safety of Repeated Autologous Infusions of Enzyme-converted Group A-to-O Red Cells into Group A Volunteers Role:PI $149,131.00 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 06-01-2006 -05-31-2007 Baxter Healthcare Corporation Clinical Evaluation of Leukofiltration of ALYX-derived Non-leukoreduced ACD-A/AS-1 RBCs Role:PI $88,724.73 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 04-30-2004 -04-30-2007 Gambro AB Evaluate Yield and inVitro Quality of Plasma and Red Blood Cells obtained by the Atreus Whole Blood System Role:PI $366,939.00 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 10-01-2004 -11-30-2006 Greiner Bio-One North America, Inc. Comparison of Blood Bank Collection Tubes Role:PI $82,433.00 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 06-30-2004 -06-30-2005 Gambro AB Evaluation of Yield and In Vitro Quality of Platelets, Plasma, and Red Blood Cells Role:PI $67,287.00 Closed Level:Industry

Investigators:Cancelas-Perez, Jose 05-15-2004 -05-15-2005 Gambro AB Evaluation of In Vitro Quality of Red Blood Cells-OrbiSac Whole Blood System Role:PI $76,559.00 Closed Level:Industry

Grant: #Gambro Supplement 3 Investigators:Cancelas-Perez, Jose 03-01-2005 -02-28-2006 Gambro AB Evaluate yield and in vitro quality of plasma and red blood cells obtained byt he Atreus WB Role:PI $90,859.23 Closed Level:Industry

Grant: #Gambro Supp 4 Investigators:Cancelas-Perez, Jose 11-01-2005 -10-31-2006 Gambro AB Autologous Recovery of Radiolabeled RBC Units Obtained afater Automated Seperation Role:PI $113,806.92 Closed Level:Industry

Grant: #004910-001 Investigators:Cancelas-Perez, Jose; Joines, Amy; Pratt, Patricia; Rugg, Neeta; Worsham, DeAlma 03-01-2007 -12-31-2007 Alpha Bio Group, LLC Clinical Trial of PRM-001 and PRM-002 Role:PI $586,082.00 Active Level:Industry

Grant: #SRS 005009 Investigators:Cancelas-Perez, Jose 05-01-2006 -04-01-2007 Haemonetics Corporation US Validation of the RBC(F)-2P Protocol and Disposable Set on the LN8150 Role:PI $67,068.92 Closed Level:Industry

Grant: #SRS 005037 Investigators:Cancelas-Perez, Jose; Pratt, Patricia; Rugg, Neeta 04-30-2007 -12-31-2010 CaridianBCT, Inc. Gambro BCT, Inc. Sponsored Research Agreement Role:PI $1,343,884.59 Active Level:Industry

Grant: #HRC-600 Investigators:Cancelas-Perez, Jose 03-10-2008 -03-09-2009 Hemerus Medical, LLC In Vitro Evaluation of Leukosep HRC-600-CLeukocyte Reduction Filtration System for RBC for Postfiltration RBC Recovery Role:PI $88,033.97 Closed Level:Industry

Grant: #CTS-0040 Investigators:Cancelas-Perez, Jose 03-01-2008 -12-31-2010 Department of the Army Medical Research and Materiel Command Inactivation of Whole Blood with Mirasol: Performance in Red Blood Cells, Platelets, and Plasma Investigation. Role:PI $595,369.58 Active Level:Federal

Grant: #PC393630 / W81XWH-06-0766 Investigators:Cancelas-Perez, Jose 05-01-2008 -10-31-2009 Department of the Army In Vitro Evaluation of Hemerus LEUKOSEP HWB-600XL Leukocyte Reduction Filtration System for Whole Blood with CPD SOLX Role:PI $262,082.32 Active Level:Federal

Grant: #PC396220 / W81XWH-06-0766 Investigators:Cancelas-Perez, Jose 07-14-2008 -12-31-2009 Department of the Army In Vitro Feasibility Study of Hemerus LEUKOSEP HWB-600-XL Leukocyte Reduction Filtration System for Whole Blood with CPD Anticoagulant Role:PI $262,082.00 Closed Level:Federal

Grant: #SRS 006045 Investigators:Cancelas-Perez, Jose 11-19-2008 -03-31-2010 Cerus Corporation A Randomized, Single-blind, Controlled, 2-Period Crossover Study of Recovery and Lifespan of Radiolabled Autologous 35-day-old RBC Role:PI $286,797.00 Closed Level:Industry

Grant: #SRS 006183 Investigators:Cancelas-Perez, Jose 04-01-2009 -06-30-2012 Department of the Army Medical Research Acquisition Activity Hemerus PC387580 SOLX Clinical Study Protocol Role:PI $1,427,604.31 Active Level:Federal

Grant: #PAWS II Investigators:Cancelas-Perez, Jose 04-24-2009 -12-31-2009 CaridianBCT, Inc. PAWS II: Blood collection study in healthy donors-evaluation of products acquired by whole blood collections Role:PI $58,000.00 Closed Level:Industry

Grant: #CIN-09-01 / W81XWH-08-D-0047 Investigators:Cancelas-Perez, Jose 08-01-2009 -07-31-2012 Department of the Army Medical Research Acquisition Activity Cryopreserved Platelets in Vitro and Murphy Study and Platelet Process Role:PI $356,240.59 Active Level:Federal

Grant: #W81XWH-08-2-0078 / H92236-08-C3005 Investigators:Cancelas-Perez, Jose 10-01-2009 -12-31-2011 Department of the Army A Clinical Study of the Safety of Ascending Doses of Autologous Lyphilized Plasma vs FFP Role:PI $251,852.09 Active Level:Federal

Grant: #SRS 006557 Investigators:Cancelas-Perez, Jose 09-11-2009 -12-31-2010 Terumo Medical Corporation Assessment of the Tacura Separator System for Double-Unit Red Blood Cell Collection Role:PI $227,543.00 Active Level:Industry

Grant: #SRS 007185 Investigators:Cancelas-Perez, Jose 08-18-2010 -08-17-2011 Pall Medical Corporation Evaluation of a Modified Leukotrap WB System Role:PI $45,568.00 Active Level:Industry

Grant: #SRS 007365 Investigators:Cancelas-Perez, Jose 03-16-2011 -12-01-2011 CaridianBCT, Inc. Protocol IV-Leukoreduced and Yield of Single Platelets Role:PI $89,644.82 Active Level:Industry

Grant: #BCT08-10TrimaV.6phRL Investigators:Cancelas-Perez, Jose 06-22-2011 -12-30-2011 CaridianBCT, Inc. Protocol III-In Vivo Platelet Study Role:PI $133,196.00 Active Level:Industry

Grant: #Pall 1101 Investigators:Cancelas-Perez, Jose 06-03-2011 -06-02-2012 Pall Medical Corporation In Vitro Evaluation of Platelets <8 Hours and <24 Hours Role:PI $100,076.00 Active Level:Industry

Grant: #BCT10-14 Investigators:Cancelas-Perez, Jose 08-15-2011 -12-30-2012 CaridianBCT, Inc. Feasibility Study to Evaluate Hemolysis in Red Blood Cells Role:PI $84,947.00 Closed Level:Industry

Grant: #Pall Protocol 1101 Addendum 1 Investigators:Cancelas-Perez, Jose 03-26-2012 -12-31-2012 Haemonetics Corporation In Vitro Evaluation of Plasma Factors Comparing <= 8 Hour and <= 24 Hour Room Temperature Holds of the Whole Blood Role:PI $53,978.03 Closed Level:Industry

Grant: #Clincial Study Agreement Investigators:Cancelas-Perez, Jose 06-01-2012 -05-31-2013 Grifols, Inc. In Vitro Study of Diagnostic Grifols WADiana Compact for ABO Role:PI $122,843.61 Active Level:Industry

Grant: #Task Order 2012-001 - VAL 00217-1\ Master is Coeus 008374 Investigators:Cancelas-Perez, Jose 06-01-2012 -05-31-2013 Cerus Corporation Product Qualification of the S303 Treatment System RBC Role:PI $28,812.24 Active Level:Industry

Grant: #Task order No. 2012-2-CL100073 Investigators:Cancelas-Perez, Jose 06-01-2012 -10-31-2013 Cerus Corporation Process Qualification of the S303 In Vitro Cross Over Study Role:PI $305,493.00 Active Level:Industry

Grant: #CTS 0080 \ V91XWH-12-20135 Investigators:Cancelas-Perez, Jose 01-15-2013 -12-31-2014 Department of Defense Improve II study: Inactivation of whole blood with Mirasol Role:PI $324,849.17 Active Level:Federal

Grant: #CTS-5010 : OPTIA_PMNC Investigators:Cancelas-Perez, Jose 03-06-2013 -02-28-2014 Terumo Medical Corporation Evaluation of Spectra Optia Apheresis System Role:PI $95,348.35 Active Level:Industry

Grant: #Fixed Price TAA Investigators:Cancelas-Perez, Jose 03-01-2013 -03-29-2013 Cerus Corporation P50 specimen testing Role:PI $3,000.00 Awarded Level:Industry

Grant: #Master Agreement Investigators:Cancelas-Perez, Jose 10-11-2013 -01-31-2014 Haemonetics Corporation Evaluation of Leukoreduction Performance of Leukosep Role:PI $36,922.00 Awarded Level:Industry

Grant: #2013-001 VAL 00260-1 Investigators:Cancelas-Perez, Jose 11-22-2013 -12-31-2014 Cerus Corporation Qualification for Treatment of Apheresis Platelets in Plasma with the Intercept Blood System for Platelets Role:PI $31,064.63 Awarded Level:Industry

Grant: #2013-002 VAL 00263-1 Investigators:Cancelas-Perez, Jose 11-22-2013 -12-31-2014 Cerus Corporation Qualification for Treatment of Apheresis Platelets in InterSol with the Intercept Blood System for Platelets Role:PI $31,064.63 Awarded Level:Industry

Grant: #Master Clinical Trial Research Agmt and Task Orders Investigators:Cancelas-Perez, Jose 01-01-2014 -07-31-2014 Uneklo USA, Inc. dba Macopharma USA Industry Sponsored Master Clinical Service Agreement and Task Orders Role:PI $384,798.62 Awarded Level:Industry

Grant: #Master Agreement Investigators:Cancelas-Perez, Jose -01-31-2015 Haemonetics Corporation In vitro Evaluation of Whole Blood Leukoreduction Performance of Hemerus LEUKOSEP HWB-600-XL Leukocyte Reduction Filtration System. Role:PI $.00 Active Level:Industry

Grant: #TP-CLN-100331 - Under Master Agreement 009003 Investigators:Cancelas-Perez, Jose 03-24-2014 -04-01-2015 Haemonetics Corporation Clinical Investigation to Evaluate the Haemonetics LeukoSep Leukocyte Reduction Filtration System for Whole Blood with CPD Anticoagulant and SOLX Additive-Pivotal Trial. Role:PI $340,954.00 Awarded Level:Industry

Grant: #Master Services Agreement Investigators:Cancelas-Perez, Jose 08-23-2012 -08-22-2022 New Health Sciences, Inc. Master Services Agreement Role:PI $.00 Active Level:Industry

Grant: #Westat - UC Teaming Agmt (USAMRAA) Investigators:Cancelas-Perez, Jose 08-25-2014 -08-24-2015 Westat, Inc. Performance of good clinical practices compliant clinical trials of Freeze Dried Plasma. (This is the Teaming Agreement pertaining to this study). Role:PI $.00 Active Level:Industry

Grant: #60000454 Investigators:Cancelas-Perez, Jose 08-15-2014 -08-14-2017 Mast Therapeutics, Inc. Testing of blood additive to improve the quality and functionality of stored red blood cells. Role:PI $168,431.42 Active Level:Industry

Grant: #Optia CMNC (CTS-5038) Investigators:Cancelas-Perez, Jose 08-01-2014 -08-30-2015 Terumo BCT, Inc. Clinical Investigation Plan CTS-5038: A randomized, crossover trial to characterize the performance of the Spectra Optia Apheresis System vs the COBE Spectra Apheresis System. Role:PI $177,246.93 Active Level:Private Non-Profit

Grant: #2014-001 CLI00095 - Master is 008374 Investigators:Cancelas-Perez, Jose 08-25-2014 -09-30-2015 Cerus Corporation Apheresis Platelet Components in 100% Plasma Role:PI $154,664.26 Awarded Level:Industry

Grant: #2014-002 CLI00099 - Master is 008374 Investigators:Cancelas-Perez, Jose 08-25-2014 -09-30-2015 Cerus Corporation A randomized, controlled, single-blind, in vivo pilot study. Role:PI $123,546.78 Awarded Level:Industry

Grant: #Task Order 2015-001 Investigators:Cancelas-Perez, Jose 02-01-2015 -01-31-2016 Cerus Corporation In Vitro Characteristics of Apheresis Platelets in InterSol. Role:PI $94,762.38 Awarded Level:Industry

Grant: #Trimal - Intersol CTS-5051 Investigators:Cancelas-Perez, Jose 01-01-2015 -12-31-2015 Terumo BCT, Inc. In-Vitro Study of Platelets Collected on Trima Accel System. Role:PI $202,941.34 Active Level:Private Non-Profit

Grant: #0047-1062-CPP1-05-HBC / W81XWH-15-C-0047 Investigators:Cancelas-Perez, Jose 01-01-2015 -03-31-2016 Department of the Army Medical Research and Materiel Command CPP1-05 Dose Escalation Study. Role:PI $471,549.00 Awarded Level:Federal

Grant: #TP-CLN 100380 (under Master Agmt) Investigators:Cancelas-Perez, Jose 06-01-2015 -09-30-2015 Haemonetics Corporation Clinical Investigation to Evaluate the Haemonetics POLFA Modified Sample Needle Assembly with Vacuum Tube Holder. Role:PI $23,629.69 Awarded Level:Industry

Grant: #Ascorbic Acid SOLX Study - Equipment Agmt (re: CCTST) Investigators:Cancelas-Perez, Jose 07-01-2015 -06-30-2017 Haemonetics Corporation Prevention of red cell storage lesion through a combinatorial approach. Role:PI $.00 Active Level:Industry

Grant: #MASTER STUDY SITE AGREEMENT Non-DOD Investigators:Cancelas-Perez, Jose 11-26-2012 -11-25-2017 Terumo BCT, Inc. Master Study Site Agreement - Non-DoD Role:PI $.00 Active Level:Private Non-Profit

Grant: #2015 Clinical Trial Agreement/Work Order #1 Investigators:Cancelas-Perez, Jose 09-01-2015 -05-03-2016 Cerus Corporation CLI 00116 Recovery and Lifespan of Intercept treated PAS/InterSol Platelet Components stored for 6 or 7 days. Role:PI $431,680.63 Active Level:Industry

Grant: #2015 Master Clinical Trial Agmt Investigators:Cancelas-Perez, Jose 11-01-2015 -10-31-2020 Cerus Corporation Master Clinical Trial Agreement. Role:PI $.00 Active Level:Industry

Grant: #Services Agreement Investigators:Cancelas-Perez, Jose 11-01-2015 -04-30-2016 Cellphire, Inc. Consultant Agreement. Role:PI $8,046.30 Awarded Level:Industry

Grant: #Research Services Agreement Investigators:Cancelas-Perez, Jose 12-01-2015 -11-30-2016 Citra Labs LLC Evaluation (in vitro) of CPD/AS-1 and CP2D/AS-3 Liquid preserved Red Blood Cells Treated with Rejuvesol Solution. Role:PI $199,619.75 Active Level:Industry

Grant: #SOW for Trima-Intersol Lab Work (under Non-DoD MSSA) Investigators:Cancelas-Perez, Jose 01-01-2015 -06-30-2016 Terumo BCT, Inc. SOW for Intersol Lab Work. Role:PI $15,300.00 Active Level:Private Non-Profit

Grant: #TrimaV7 CTA Investigators:Cancelas-Perez, Jose 01-15-2016 -12-31-2017 Terumo BCT, Inc. Evaluation of the Performance of Trima Accel Version 7.0 Software. Role:PI $151,353.48 Active Level:Private Non-Profit

Grant: #Protocol 16-001 Investigators:Cancelas-Perez, Jose 07-22-2016 -07-21-2017 Citra Labs LLC Evaluation (in vitro) of CPD/AS-1 and CP2D/AS-3 liquid preserved red blood cells treated with Rejuvesol solution, incubated using dry-air, and washed. Role:PI $145,010.50 Active Level:Industry

Grant: #MCTA WO 2, Central Lab Investigators:Cancelas-Perez, Jose 10-05-2016 -10-04-2017 Cerus Corporation Central Lab Testing-Statement of Work #2. Role:PI $20,959.59 Active Level:Industry

Grant: #MCTA WO 3, Central Lab Investigators:Cancelas-Perez, Jose 10-05-2016 -10-04-2017 Cerus Corporation Central Lab Testing Work Order #3. Role:PI $24,958.03 Active Level:Industry

Grant: #MCTA WO 7 Investigators:Cancelas-Perez, Jose 11-01-2016 -10-31-2017 Cerus Corporation A Prospective, Randomized, In Vitro Study of Apheresis Platelet Components in 100% Plasma for Qualification of InterCept Blood System for Platelets. Role:PI $334,046.37 Active Level:Industry

Grant: #MCTA W.O.#5 Investigators:Cancelas-Perez, Jose 08-01-2016 -07-31-2017 Cerus Corporation Validation of the Preparation Steps Preceding the Radiolabeling of Apheresis Platelets in 100% Plasma for Survival and Recovery Studies. Role:PI $76,025.06 Active Level:Industry

Grant: #2012 DoD MSSA Investigators:Cancelas-Perez, Jose 11-26-2012 -11-25-2015 Department of Defense Master Study Site Agreement - DoD Role:PI $.00 Closed Level:Federal

Grant: #MCTA WO 4 Investigators:Cancelas-Perez, Jose 02-01-2016 -10-31-2016 Cerus Corporation RAD-A-A-I. Comparison of three radiolabeling protocols on 6-day and 7-day stored apheresis platelets with and without Intercept treatment. Role:PI $59,983.85 Active Level:Industry

Grant: #MCTA WO #6 Investigators:Cancelas-Perez, Jose 12-01-2016 -12-01-2021 Cerus Corporation ATP and P-Selectin testing for Cerus. Role:PI $175,000.00 Active Level:Industry

Grant: #Master Agreement 17-01 / W81XWH-13-C-0167 Investigators:Cancelas-Perez, Jose 03-01-2017 -09-11-2019 Department of the Army Medical Research Acquisition Activity Subcontract Master Agreement. Role:PI $.00 Active Level:Federal

Grant: #Work Order No. 1 (see Master-010779) Investigators:Cancelas-Perez, Jose 03-01-2017 -09-30-2017 Department of the Army Medical Research Acquisition Activity In Vitro Comparison of Cryopreserved Platelets to Apheresis Platelets. Role:PI $203,110.00 Awarded Level:Federal

Grant: #AmiCORE Apheresis Eval Investigators:Cancelas-Perez, Jose 07-01-2017 -06-30-2018 Fenwal Amicore apheresis system: in vitro evaluation of triple platelet products stored for five days in 100% plasma. Role:PI $95,982.52 Active Level:Industry

Grant: #Trima Accel System Investigators:Cancelas-Perez, Jose 03-01-2017 -02-28-2018 Terumo BCT, Inc. An evaluation of an in vivo recovery and survival study of platelets collected on the Trima Accel System and stored in InterSol Solution. Role:PI $165,287.31 Active Level:Private Non-Profit

Grant: #Master General Services Agmt Investigators:Cancelas-Perez, Jose 08-01-2017 -07-31-2019 Terumo BCT, Inc. General Services Master Agreement. Role:PI $.00 Active Level:Private Non-Profit

Grant: #ITS-1149 Testing (see 010159 for terms) Investigators:Cancelas-Perez, Jose 08-01-2017 -07-31-2019 Terumo BCT, Inc. General Services Agreement. Role:PI $13,915.59 Active Level:Private Non-Profit

Grant: #NHSi / R44 HL132172 Investigators:Cancelas-Perez, Jose 06-15-2017 -06-14-2018 National Heart, Lung and Blood Institute Dose escalation study design. Role:PI $151,234.19 Active Level:Federal

Grant: #1017-001-HOX Investigators:Cancelas-Perez, Jose 10-10-2017 -09-30-2018 Biomedical Advanced Research and Development Authority Identification of viable, alloreactive T-cells in thrombocyte products. Role:PI $25,498.00 Active Level:Federal

Grant: #CP2017-1 Investigators:Cancelas-Perez, Jose; Medlin, Stephen 12-01-2017 -05-31-2018 Biomedical Advanced Research and Development Authority A Phase I, Multi-Center, Open-Label, Dose Escalation Study of Thrombosomes in Bleeding Thrombocytopenic Patients in Three Cohorts. Role:PI $170,513.00 Active Level:Federal

Grant: #Terumo BCT/HHSO100201600013C Investigators:Cancelas-Perez, Jose 09-07-2017 -09-06-2020 Biomedical Advanced Research and Development Authority Verification Protocol for in vitro Cell Quality of Mirasol-Treated Platelets in 100% Plasma Collected on Trima Accel. Role:PI $316,467.60 Active Level:Federal

Grant: #NHSi / R44 HL132172 Investigators:Cancelas-Perez, Jose 06-15-2017 -06-14-2018 National Heart, Lung and Blood Institute Clinical investigation to evaluate the New Health Sciences Hemanext Oxygen Reduction System. Role:PI $451,729.40 Active Level:Federal

Grant: #85104 Investigators:Cancelas-Perez, Jose; Gardner, Jason 01-01-2018 -12-31-2021 Shriners Hospitals for Children - Cincinnati Erythropoietin resistant anemia induced by thermal injury Role:Collaborator $239,500.00 Active Level:Private Non-Profit

Grant: #Cerus Corp Task Order #8 sub BARDA Investigators:Cancelas-Perez, Jose 08-09-2018 -02-01-2019 Biomedical Advanced Research and Development Authority Measurement of the Recovery and Lifespan of Red Blood Cells from Pathogen-Reduced, Stored Blood Units Using Cellular Biotinylation. Role:PI $132,862.32 Active Level:Federal

Grant: #MATX-005-CMD Investigators:Cancelas-Perez, Jose 08-31-2018 -04-30-2019 Fenwal MATX-005-CMD Role:PI $129,845.56 Active Level:Industry

Grant: #2019 ISRA_Fenwal Investigators:Cancelas-Perez, Jose 01-01-2019 -12-31-2019 Fenwal In Vitro Clinical Evaluation for the Transition of Baxter PL-146 to Renolit 326 and Baxter PL-2209 to Renolit 3720 Plastics for the Blood-Pack Unit. Role:PI $285,014.33 Awarded Level:Industry

Grant: #Master Clinical Trial Agmt and Task Orders Investigators:Cancelas-Perez, Jose 12-17-2018 -12-31-2023 Uneklo USA, Inc. dba Macopharma USA Industry Sponsored Master Clinical Research Agreement. Role:PI $.00 Active Level:Industry

Grant: #Master Clinical Research Agreement Investigators:Cancelas-Perez, Jose 12-17-2018 -12-31-2023 Uneklo USA, Inc. dba Macopharma USA Industry Sponsored Master Clinical Research Agreement. Role:PI $.00 Active Level:Industry

Grant: #Task Order #1 under the MA Investigators:Cancelas-Perez, Jose 05-01-2019 -05-01-2020 Uneklo USA, Inc. dba Macopharma USA Task Order #1 under master contract with MacoPharma. Role:PI $35,146.51 Awarded Level:Industry

Grant: #Task Order #2 under the MA Investigators:Cancelas-Perez, Jose 05-01-2019 -05-01-2020 Uneklo USA, Inc. dba Macopharma USA Task Order #2 under master contract with MacoPharma. Role:PI $39,809.33 Awarded Level:Industry

Grant: #Task Order #3 under the MA Investigators:Cancelas-Perez, Jose 05-01-2019 -05-01-2020 Uneklo USA, Inc. dba Macopharma USA Task Order #3 under master contract with MacoPharma. Role:PI $49,942.96 Awarded Level:Industry

Grant: #Work Order #9 under the MA Investigators:Cancelas-Perez, Jose 09-11-2019 -12-31-2019 Cerus Corporation Qualification of Platelet Processing for Radiolabeling of Intercept Platelets in 100% Plasma for Recovery and Survival Studies REL 582 Role:PI $17,073.20 Awarded Level:Industry

Grant: #CytoSorbents / R44HL141928 Investigators:Cancelas-Perez, Jose 01-01-2019 -06-30-2020 National Heart, Lung and Blood Institute In Vivo Evaluation of Red Blood Cell Recovery after Filtration through the HemoDefend RBC Potassium Adsorber. Role:PI $50,883.00 Awarded Level:Federal

Grant: #Work Order 10 Investigators:Cancelas-Perez, Jose 10-14-2019 -02-28-2021 Cerus Corporation A Randomized, Multi-center, Multi-stage, Controlled, In Vivo Study to assess the Recovery & Survival of Radiolabled Autologous INTERCEPT Apheresis Platelet Components. Role:PI $383,323.79 Awarded Level:Industry

Grant: #Exhibit A_SOW 5 Investigators:Cancelas Perez, Jose 06-15-2020 -06-14-2021 Terumo BCT, Inc. APC-60 Study, SOW#5 Role:PI $102,771.82 Active Level:Industry

Grant: #SOW 4 / H92222-16-C-0081 Investigators:Cancelas Perez, Jose 05-01-2020 -12-31-2020 Department of the Army TerumoBCT - Statement of Work No.4 Role:PI $144,098.63 Active Level:Federal

Grant: #Hererus Master Agreement Investigators:Cancelas Perez, Jose 05-01-2020 -12-31-2023 Hemerus Medical, LLC Hemerus. - Master Clinical Research Agreement Role:PI $.00 Active Level:Industry

Grant: #Exhibit A_under the Master Agreement Investigators:Cancelas Perez, Jose 11-01-2019 -01-31-2021 Terumo BCT, Inc. TerumoBCT Pooling Set Study - Statement of Work #3 Role:PI $150,000.00 Awarded Level:Industry

Grant: #Velico Meidcal sub BARDA Investigators:Cancelas Perez, Jose 04-01-2020 -03-31-2021 Biomedical Advanced Research and Development Authority Formative Study Role:PI $60,318.99 Active Level:Federal

Grant: #ALYX-001 Fenwall Contract Investigators:Cancelas Perez, Jose 01-01-2021 -12-31-2021 Fresenius Kabi In Vitro and In Vivo Evaluation of an Alternate Filter for the ALYX A200 Leukoreduction Filter - Amendment #4 Role:PI $201,615.75 Awarded Level:Industry

Grant: #2021 Exhibit A - 01 Investigators:Cancelas Perez, Jose 02-01-2021 -01-31-2022 Hemerus Medical, LLC Hemerus: APEX Study - Amendment #1 Role:PI $16,695.82 Awarded Level:Industry

Grant: #MEQU Research Agreement Investigators:Cancelas Perez, Jose 01-01-2021 -12-31-2021 MEQU Blood product alterations due to Exposue to the M WARMER SYSTEM Role:PI 129845.56 Hold Level:Industry

Grant: #Cellphire/BARDA TCP CTA Investigators:Cancelas Perez, Jose; Hambley, Bryan 03-01-2021 -12-31-2026 Biomedical Advanced Research and Development Authority A Prospective, Multicenter, Randomized, Open-Label Phase 2, Parallel, Dose Ranging Multidose Study of Thrombosomes® vs Liquid Stored Platelets (LSP) in Bleeding Thrombocytopenic Patients Role:PI 0.00 Hold Level:Federal

Grant: #SOW 6 / H92222-16-C-0081 Investigators:Cancelas Perez, Jose 06-01-2021 -03-31-2022 Terumo BCT, Inc. Terumo BCT Clinical Trial Agreement - SOW #6 (Reveos System) Role:PI 0.00 Hold Level:Industry

Investigators:Cancelas Perez, Jose 07-01-2021 -06-30-2022 Terumo BCT, Inc. Terumo BCT Clinical Trial Agreement (CTA) - SOW #7 (Reveos System) CTS-5085 Role:PI 0.00 Hold Level:Industry

Grant: #Addendum-1 Task Order 21 (MEQU) Investigators:Cancelas Perez, Jose 09-30-2021 -03-30-2022 United States Special Operations Command Academic Consortium UC Blood Warmer Study (Addendum 1 - Task Order 21) (MEQU) Role:PI 0.00 Hold Level:Federal

Investigators:Cancelas Perez, Jose 01-01-2022 -12-31-2022 Becton, Dickinson and Company Method Comparison and Inter-Site Reproducibility Evaluation of the BD Leucocount Kit on the BD FACSLyric Clinical System Role:PI 118271.17 Hold Level:Industry

Grant: #SOW 7 Investigators:Cancelas Perez, Jose 11-01-2021 -03-30-2023 Terumo BCT, Inc. Terumo BCT Statement of Work No. 7 - Rental Space-FDP System Role:PI 85000.00 Hold Level:Industry

Grant: #ISRA / 75A50121C00059 Investigators:Cancelas Perez, Jose 01-01-2022 -12-31-2022 Velico Medical Velico - Evaluation for the Safety & Efficacy of Frontline ODP in a Multi-Dose Randomized Cohort Study Compared to PF24 (Study #2) Role:PI 498542.00 Hold Level:Industry

Grant: #BCH tba/ P01HL158688 Investigators:Cancelas Perez, Jose 08-15-2022 -07-31-2027 National Heart, Lung and Blood Institute Novel Strategies to Improve Blood Transfusion Practice Role:PI 279631.00 Hold Level:Federal

Grant: #APEX-1 / W81XWH-22-2-0009 Investigators:Cancelas Perez, Jose 06-01-2022 -05-31-2023 Department of the Army Medical Research Acquisition Activity Hemerus - WB in Vitro-Pre-Clinical Laboratory Analysis (Amendment 2) Role:PI 0.00 Hold Level:Federal

Grant: #FA8650-22-2-6K10 / Master FA8650-21-2-6285 Investigators:Cancelas Perez, Jose; Pritts, Timothy 12-02-2022 -09-01-2024 Air Force Research Laboratory Evaluation of a Novel Filter Strategy to Reduce Donated Whole Blood Antibody Titers Role:Collaborator 0.00 Hold Level:Federal

Grant: #A3 / W81XWH-22-2-0009 Investigators:Cancelas Perez, Jose 01-01-2023 -12-31-2023 Department of the Army Medical Research Acquisition Activity Hemerus - APEX-1 Pilot Study (In Vitro Parameter Testing) (Amendment 3) Role:PI 9924.72 Hold Level:Federal

Investigators:Cancelas Perez, Jose 01-01-2023 -06-30-2023 MEQU Alterations in Whole Blood (hemolysis and platelets) due to exposure to The M WARMER SYSTEM Role:PI 57696.00 Hold Level:Industry

Investigators:Cancelas Perez, Jose 07-18-2023 -12-31-2025 Terumo BCT, Inc. Termuo SOW# 8 - Collection of Blood Products Acquired by the Trima Accel System into Non-DEHP Disposable Tubing Sets for Laboratory Evaluations Role:PI 477446.72 Hold Level:Industry

Grant: #TFDP SOW #8 Investigators:Cancelas Perez, Jose 03-31-2023 -09-30-2023 Biomedical Advanced Research and Development Authority Terumo SOW# 9 - Manufacturing of Freeze Dried Plasma for the purpose of Process Qualification/In Vitro testing (FDP) Role:PI 0.00 Hold Level:Federal

Grant: #75A50123C00052 Investigators:Cancelas Perez, Jose; Rugg, Neeta 09-15-2023 -09-14-2024 Biomedical Advanced Research and Development Authority Development, Validation & Use of Biotinylation to Measure Post-transfusion Red Blood Cell Kinetics in the Context of Regulatory Studies for the approval of Novel or Modified Blood Products in the USA Role:PI 2734700.00 Hold Level:Federal

Grant: #VAL 00897-01 Investigators:Cancelas Perez, Jose 10-01-2023 -12-31-2024 Biomedical Advanced Research and Development Authority Cerus - Work Order#11 VAL 00897-1 Role:PI 79676.00 Hold Level:Federal

Grant: #OGB4; SBIR; 2R44HL123103-02 Investigators:Cancelas, Jose 09-05-2023 -08-31-2024 National Heart, Lung and Blood Institute Rho GTPase inhibitor for refrigerated platelet storage Role:PI 211923.00 Hold Level:Federal

Grant: #FA8650-24-2-6K14 Investigators:Alquist, Caroline; Cancelas, Jose; Goodman, Michael; Pritts, Timothy 04-11-2024 -07-10-2025 Air Force Research Laboratory Evaluation of Imlifidase to Reduce Donated Blood Antibody Titers Role:Collaborator 349944.00 Hold Level:Federal

Investigators:Cancelas, Jose; Rugg, Neeta 04-18-2024 -06-30-2025 Terumo BCT, Inc. Terumo - CTS-5091 - New CTA Role:PI 208000.07 Hold Level:Industry

Peer Reviewed Publications

Cancelas Pérez, J A; Perez de Oteyza, J; Megido, M; Garcia-Laraña, J; Odriozola, J; Suarez, J; Rocamora, A (1992. ) Chemotherapy-induced neutrophilic eccrine hidradenitis in acute myeloid leukemia. Acta haematologica, , 87 (3 ) ,167-8

Erdozain Sosa, J C; Cancelas Pérez, J A; Sánchez Ruano, J J; Cano Ruiz, A (1990. ) [Bone marrow dysfunction in chronic liver disease: case study]. Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva, , 78 (5 ) ,324-5

Cancelas, Jose A; Dumont, Larry J; Rugg, Neeta; Szczepiorkowski, Zbigniew M; Herschel, Louis; Siegel, Alan; Pratt, P Gayle; Worsham, D Nicole; Erickson, Anne; Propst, Meisa; North, Anne; Sherman, Claire D; Mufti, Nina A; Reed, William F; Corash, Laurence (2011. ) Stored red blood cell viability is maintained after treatment with a second-generation S-303 pathogen inactivation process.Transfusion, , 51 (11 ) ,2367-76 More Information

Miller, S J; Lan, Z D; Hardiman, A; Wu, J; Kordich, J J; Patmore, D M; Hegde, R S; Cripe, T P; Cancelas, J A; Collins, M H; Ratner, N (2010. ) Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.Oncogene, , 29 (3 ) ,368-79 More Information

Sanchez-Aguilera, A; Rattmann, I; Drew, D Z; Müller, L U W; Summey, V; Lucas, D M; Byrd, J C; Croce, C M; Gu, Y; Cancelas, J A; Johnston, P; Moritz, T; Williams, D A (2010. ) Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.Leukemia, , 24 (1 ) ,97-104 More Information

Akbar, H; Kim, J; Funk, K; Cancelas, J A; Shang, X; Chen, L; Johnson, J F; Williams, D A; Zheng, Y (2007. ) Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.Journal of thrombosis and haemostasis : JTH, , 5 (8 ) ,1747-55 More Information

Guo, Fukun; Cancelas, Jose A; Hildeman, David; Williams, David A; Zheng, Yi (2008. ) Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development.Blood, , 112 (5 ) ,1767-75 More Information

Müller, L U W; Schore, R J; Zheng, Y; Thomas, E K; Kim, M-O; Cancelas, J A; Gu, Y; Williams, D A (2008. ) Rac guanosine triphosphatases represent a potential target in AML.Leukemia, , 22 (9 ) ,1803-6 More Information

Ghiaur, Gabriel; Lee, Andrew; Bailey, Jeff; Cancelas, Jose A; Zheng, Yi; Williams, David A (2006. ) Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment.Blood, , 108 (6 ) ,2087-94 More Information

AuBuchon, James P; Cancelas, Jose A; Herschel, Louise; Roger, Jill; Rugg, Neeta; Pratt, Patricia G; Joines, Amy; Gormas, Jennifer F; Zia, Majid; Spearman, Michael R (2006. ) In vitro and in vivo evaluation of LEUKOSEP HRC-600-C leukoreduction filtration system for red cells.Transfusion, , 46 (8 ) ,1311-5 More Information

Cabezudo, E; Querol, S; Cancelas, J A; García, J (1999. ) Comparison of volumetric capillary cytometry with standard flow cytometry for routine enumeration of CD34+ cells. Transfusion, , 39 (8 ) ,864-72

Gallardo, D; García-López, J; Sureda, A; Canals, C; Ferra, C; Cancelas, J A; Berlanga, J J; Brunet, S; Boqué, C; Picón, M; Torrico, C; Amill, B; Martino, R; Martínez, C; Martín-Henao, G; Domingo-Albós, A; Grañena, A (1997. ) Low-dose donor CD8+ cells in the CD4-depleted graft prevent allogeneic marrow graft rejection and severe graft-versus-host disease for chronic myeloid leukemia patients in first chronic phase.Bone marrow transplantation, , 20 (11 ) ,945-52 More Information

Limón, A; Briones, J; Puig, T; Carmona, M; Fornas, O; Cancelas, J A; Nadal, M; García, J; Rueda, F; Barquinero, J (1997. ) High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hematopoietic cells. Blood, , 90 (9 ) ,3316-21

Martínez, C; Sureda, A; Martino, R; Cancelas, J A; Madoz, P; García, J; Brunet, S (1997. ) Efficient peripheral blood stem cell mobilization with low-dose G-CSF (50 microg/m2) after salvage chemotherapy for lymphoma.Bone marrow transplantation, , 20 (10 ) ,855-8 More Information

Sastre, J L; Pérez-Oteyza, J; López, J; Cerveró, C; Sánchez-Sousa, A; García-Laraña, J; Cancelas, J A; Odriozola, J; Navarro, J L (1994. ) [Pulmonary mucormycosis in leukemic patients. Apropos of 2 cases]. Sangre, , 39 (1 ) ,53-5

Lopez, J; Ulibarrena, C; Gonzalez-Porque, P; Navas, G; Roldan, E; Cancelas, J A; Perez-Oteyza, J; Burgaleta, C; García-Laraña, J; Sastre, J L (1993. ) Amylase-producing Bence Jones multiple myeloma with pancreatitis-like symptoms. Acta haematologica, , 90 (2 ) ,99-101

Tidwell, Timothy; Wechsler, Jeremy; Nayak, Ramesh C; Trump, Lisa; Salipante, Stephen J; Cheng, Jerry C; Donadieu, Jean; Glaubach, Taly; Corey, Seth J; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A; Horwitz, Marshall S (2014. ) Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.Blood, , 123 (4 ) ,562-9 More Information

Nayak, Ramesh C; Chang, Kyung-Hee; Vaitinadin, Nataraja-Sarma; Cancelas, Jose A (2013. ) Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells.Immunological reviews, , 256 (1 ) ,255-68 More Information

Ishikawa, Eri Taniguchi; Cancelas, Jose A (2012. ) Lack of communication rusts and ages stem cells.Cell cycle (Georgetown, Tex.), , 11 (17 ) ,3149-50 More Information

Taniguchi Ishikawa, Eri; Gonzalez-Nieto, Daniel; Ghiaur, Gabriel; Dunn, Susan K; Ficker, Ashley M; Murali, Bhuvana; Madhu, Malav; Gutstein, David E; Fishman, Glenn I; Barrio, Luis C; Cancelas, Jose A (2012. ) Connexin-43 prevents hematopoietic stem cell senescence through transfer of reactive oxygen species to bone marrow stromal cells.Proceedings of the National Academy of Sciences of the United States of America, , 109 (23 ) ,9071-6 More Information

Gonzalez-Nieto, Daniel; Li, Lina; Kohler, Anja; Ghiaur, Gabriel; Ishikawa, Eri; Sengupta, Amitava; Madhu, Malav; Arnett, Jorden L; Santho, Rebecca A; Dunn, Susan K; Fishman, Glenn I; Gutstein, David E; Civitelli, Roberto; Barrio, Luis C; Gunzer, Matthias; Cancelas, Jose A (2012. ) Connexin-43 in the osteogenic BM niche regulates its cellular composition and the bidirectional traffic of hematopoietic stem cells and progenitors.Blood, , 119 (22 ) ,5144-54 More Information

Cancelas, J A (2011. ) On how Rac controls hematopoietic stem cell activity.Transfusion, , 51 Suppl 4 ,153S-159S More Information

Mulloy, James C; Cancelas, Jose A; Filippi, Marie-Dominique; Kalfa, Theodosia A; Guo, Fukun; Zheng, Yi (2010. ) Rho GTPases in hematopoiesis and hemopathies.Blood, , 115 (5 ) ,936-47 More Information

Wei, Junping; Wunderlich, Mark; Fox, Catherine; Alvarez, Sara; Cigudosa, Juan C; Wilhelm, Jamie S; Zheng, Yi; Cancelas, Jose A; Gu, Yi; Jansen, Michael; Dimartino, Jorge F; Mulloy, James C (2008. ) Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Cancer cell, , 13 (6 ) ,483-95 More Information

Cancelas, Jose A; Lee, Andrew W; Prabhakar, Rethinasamy; Stringer, Keith F; Zheng, Yi; Williams, David A (2005. ) Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization.Nature medicine, , 11 (8 ) ,886-91 More Information

Querol, S; Capmany, G; Cancelas, J A; García, J (1998. ) Expansion of cord blood progenitor cells. Bone marrow transplantation, , 21 Suppl 3 ,S77-80

Serke, S; Arseniev, L; Watts, M; Fritsch, G; Ingles-Esteve, J; Johnsen, H E; Linch, D; Cancelas, J A; Meyer, O; Kadar, J G; Huhn, D; Matcham, J (1997. ) Imprecision of counting CFU-GM colonies and CD34-expressing cells.Bone marrow transplantation, , 20 (1 ) ,57-61 More Information

Cancelas, J A; Querol, S (1995. ) Graft failure after an umbilical cord blood transplant in a patient with severe aplastic anemia. Blood, , 86 (9 ) ,3610

Sastre, J L; Escribano, L; Montilla, P; Ulibarrena, C; Cancelas, J A (1994. ) [Hypereosinophilic syndrome induced by GM-CSF in a patient with AIDS. Possible response to alpha-interferon treatment]. Sangre, , 39 (5 ) ,398-9

Lousa, M; Sastre, J L; Cancelas, J A; Gobernado, J M; Pardo, A (1994. ) Study of antiphospholipid antibodies in a patient with Sneddon's syndrome and her family. Stroke; a journal of cerebral circulation, , 25 (5 ) ,1071-4

Cancelas, J A; Alvarez, F; Navarro, J L; César, J M (1994. ) [Splenic irradiation as a treatment for chronic idiopathic thrombocytopenic purpura]. Sangre, , 39 (2 ) ,152-3

Dumont, Larry J; Cancelas, Jose A; Maes, Lou Ann; Rugg, Neeta; Whitley, Pamela; Herschel, Louise; Siegal, Alan H; Szczepiorkowski, Zbigniew M; Hess, John R; Zia, Majid (2015. ) Overnight, room temperature hold of whole blood followed by 42-day storage of red blood cells in additive solution-7.Transfusion, , 55 (3 ) ,485-90 More Information

Cancelas, Jose A; Padmanabhan, Anand; Le, Tuan; Ambruso, Daniel R; Rugg, Neeta; Worsham, D Nicole; Pinkard, Susan L; Graminske, Sharon; Buck, Jennifer; Goldberg, Julie; Bill, Jerry (2014. ) Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial.Transfusion, , More Information

Privette Vinnedge, L M; Benight, N M; Wagh, P K; Pease, N A; Nashu, M A; Serrano-Lopez, J; Adams, A K; Cancelas, J A; Waltz, S E; Wells, S I (2014. ) The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.Oncogene, , More Information

Yamada, Yoshiyuki; Cancelas, Jose A; Rothenberg, Marc E (2014. ) Murine models of eosinophilic leukemia: a model of FIP1L1-PDGFR? initiated chronic eosinophilic leukemia/systemic mastocytosis.Methods in molecular biology (Clifton, N.J.), , 1178 ,309-20 More Information

Dumont, Larry J; Cancelas, Jose A; Graminske, Sharon; Friedman, Kenneth D; Vassallo, Ralph R; Whitley, Pamela H; Rugg, Neeta; Dumont, Deborah F; Herschel, Louise; Siegal, Alan H; Szczepiorkowski, Zbigniew M; Fender, Logan; Razatos, Anna (2013. ) In vitro and in vivo quality of leukoreduced apheresis platelets stored in a new platelet additive solution.Transfusion, , 53 (5 ) ,972-80 More Information

Sengupta, Amitava; Cancelas, Jose A (2011. ) A conundrum in mammalian hematopoietic stem cell polarity.Cell cycle (Georgetown, Tex.), , 10 (24 ) ,4191-2 More Information

Mayes, Debra A; Rizvi, Tilat A; Cancelas, Jose A; Kolasinski, Nathan T; Ciraolo, Georgianne M; Stemmer-Rachamimov, Anat O; Ratner, Nancy (2011. ) Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation.Cancer research, , 71 (13 ) ,4675-85 More Information

Williams, Jon P; Wu, Jianqiang; Johansson, Gunnar; Rizvi, Tilat A; Miller, Shyra C; Geiger, Hartmut; Malik, Punam; Li, Wenling; Mukouyama, Yoh-suke; Cancelas, Jose A; Ratner, Nancy (2008. ) Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.Cell stem cell, , 3 (6 ) ,658-69 More Information

Ghiaur, Gabriel; Ferkowicz, Michael J; Milsom, Michael D; Bailey, Jeff; Witte, David; Cancelas, Jose A; Yoder, Mervin C; Williams, David A (2008. ) Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells.Blood, , 111 (7 ) ,3313-21 More Information

Williams, David A; Zheng, Yi; Cancelas, Jose A (2008. ) Rho GTPases and regulation of hematopoietic stem cell localization.Methods in enzymology, , 439 ,365-93 More Information

Kelly, Patrick F; Radtke, Susan; von Kalle, Christof; Balcik, Brenden; Bohn, Kimberley; Mueller, Robin; Schuesler, Todd; Haren, Moira; Reeves, Lilith; Cancelas, Jose A; Leemhuis, Thomas; Harris, Richard; Auerbach, Arleen D; Smith, Franklin O; Davies, Stella M; Williams, David A (2007. ) Stem cell collection and gene transfer in Fanconi anemia.Molecular therapy : the journal of the American Society of Gene Therapy, , 15 (1 ) ,211-9 More Information

Yamada, Yoshiyuki; Rothenberg, Marc E; Cancelas, Jose A (2006. ) Current concepts on the pathogenesis of the hypereosinophilic syndrome/chronic eosinophilic leukemia. Translational oncogenomics, , 1 ,53-63

Chandra, Saurabh; Levran, Orna; Jurickova, Ingrid; Maas, Chiel; Kapur, Rick; Schindler, Detlev; Henry, Rashida; Milton, Kelly; Batish, Sat Dev; Cancelas, Jose A; Hanenberg, Helmut; Auerbach, Arleen D; Williams, David A (2005. ) A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients.Molecular therapy : the journal of the American Society of Gene Therapy, , 12 (5 ) ,976-84 More Information

Querol, S; Cancelas, J A; Amat, L; Capmany, G; Garcia, J (1999. ) Effect of glycosylation of recombinant human granulocytic colony-stimulating factor on expansion cultures of umbilical cord blood CD34+ cells. Haematologica, , 84 (6 ) ,493-8

van Hennik, P B; Verstegen, M M; Bierhuizen, M F; Limón, A; Wognum, A W; Cancelas, J A; Barquinero, J; Ploemacher, R E; Wagemaker, G (1998. ) Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multilineage engraftment of immunodeficient mice. Blood, , 92 (11 ) ,4013-22

Martín-Satué, M; Marrugat, R; Cancelas, J A; Blanco, J (1998. ) Enhanced expression of alpha(1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells. Cancer research, , 58 (7 ) ,1544-50

Martín-Henao, G A; Inglés-Esteve, J; Cancelas, J A; García, J (1996. ) Isolation of CD34+ hematopoietic progenitor cells in chronic myeloid leukemia by magnetic activated cell sorting (MACS). Bone marrow transplantation, , 18 (3 ) ,603-9

López-Jimenez, J; Cancelas, J A; García-Laraña, J; Sastre, J L; Cerveró, C; Zamora, C; Megido, M; Hernández-Jodra, M; Lasa, E; Pérez-Oteyza, J (1995. ) Posttransfusion hepatitis after induction chemotherapy in acute nonlymphoblastic leukemia: implications for long-term management and outcome. Transfusion, , 35 (4 ) ,313-8

López, J; Cancelas, J A; Valiño, J M; García-Laraña, J; Sastre, J L; Pérez-Oteyza, J; Cerveró, C; García-Avello, A; Cabezudo, E; Arranz, M I (1994. ) [Pentoxifylline is not useful in the prevention of toxicity associated with bone marrow transplantation]. Medicina clínica, , 102 (13 ) ,485-8

Garcia-Avello, A; Garcia-Frade, L J; Gandarias, C; Ocaña, J; Cancelas, J A; Lasso, M (1994. ) High F1.2 fragment of prothrombin, thrombin-antithrombin III complex (TAT) and soluble fibrin plasma levels demonstrate hypercoagulability induced during loco-regional thrombolytic therapy with rt-PA. Thrombosis research, , 73 (2 ) ,109-15

Cancelas, Jose A; Dumont, Larry J; Maes, Lou A; Rugg, Neeta; Herschel, Louise; Whitley, Pamela H; Szczepiokowski, Zbigniew M; Siegel, Alan H; Hess, John R; Zia, Majid (2015. ) Additive solution-7 reduces the red blood cell cold storage lesion.Transfusion, , 55 (3 ) ,491-8 More Information

Chang, Kyung Hee; Nayak, Ramesh C; Roy, Swarnava; Perumbeti, Ajay; Wellendorf, Ashley M; Bezold, Katie Y; Pirman, Megan; Hill, Sarah E; Starnes, Joseph; Loberg, Anastacia; Zhou, Xuan; Inagami, Tadashi; Zheng, Yi; Malik, Punam; Cancelas, Jose A (2015. ) Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT?R and cytoskeletal dysregulation.Nature communications, , 6 ,5914 More Information

Chang, Kyung Hee; Sengupta, Amitava; Nayak, Ramesh C; Duran, Angeles; Lee, Sang Jun; Pratt, Ronald G; Wellendorf, Ashley M; Hill, Sarah E; Watkins, Marcus; Gonzalez-Nieto, Daniel; Aronow, Bruce J; Starczynowski, Daniel T; Civitelli, Roberto; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A (2014. ) p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-?B/Ccl4 signaling at the bone marrow macrophage-osteoblast niche.Cell reports, , 9 (6 ) ,2084-97 More Information

Fang, Jing; Barker, Brenden; Bolanos, Lyndsey; Liu, Xiaona; Jerez, Andres; Makishima, Hideki; Christie, Susanne; Chen, Xiaoting; Rao, Dinesh S; Grimes, H Leighton; Komurov, Kakajan; Weirauch, Matthew T; Cancelas, Jose A; Maciejewski, Jaroslaw P; Starczynowski, Daniel T (2014. ) Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-?B gene network.Cell reports, , 8 (5 ) ,1328-38 More Information

Mock, Donald M; Widness, John A; Veng-Pedersen, Peter; Strauss, Ronald G; Cancelas, Jose A; Cohen, Robert M; Lindsell, Christopher J; Franco, Robert S (2014. ) Measurement of posttransfusion red cell survival with the biotin label.Transfusion medicine reviews, , 28 (3 ) ,114-25 More Information

Velu, Chinavenmeni S; Chaubey, Aditya; Phelan, James D; Horman, Shane R; Wunderlich, Mark; Guzman, Monica L; Jegga, Anil G; Zeleznik-Le, Nancy J; Chen, Jianjun; Mulloy, James C; Cancelas, Jose A; Jordan, Craig T; Aronow, Bruce J; Marcucci, Guido; Bhat, Balkrishen; Gebelein, Brian; Grimes, H Leighton (2014. ) Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.The Journal of clinical investigation, , 124 (1 ) ,222-36 More Information

Zhou, Xuan; Florian, Maria Carolina; Arumugam, Paritha; Chen, Xiaoyi; Cancelas, Jose A; Lang, Richard; Malik, Punam; Geiger, Hartmut; Zheng, Yi (2013. ) RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors.The Journal of experimental medicine, , 210 (11 ) ,2371-85 More Information

Dumont, Larry J; Cancelas, Jose A; Dumont, Deborah F; Siegel, Alan H; Szczepiorkowski, Zbigniew M; Rugg, Neeta; Pratt, P Gayle; Worsham, D Nicole; Hartman, Elizabeth L; Dunn, Susan K; O'Leary, Margaret; Ransom, Janet H; Michael, Rodney A; Macdonald, Victor W (2013. ) A randomized controlled trial evaluating recovery and survival of 6% dimethyl sulfoxide-frozen autologous platelets in healthy volunteers.Transfusion, , 53 (1 ) ,128-37 More Information

Shang, Xun; Cancelas, Jose A; Li, Lina; Guo, Fukun; Liu, Wei; Johnson, James F; Ficker, Ashley; Daria, Deidre; Geiger, Hartmut; Ratner, Nancy; Zheng, Yi (2011. ) R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.The Journal of biological chemistry, , 286 (27 ) ,24068-78 More Information

Cancelas, Jose A; Rugg, Neeta; Fletcher, Dana; Pratt, P Gayle; Worsham, D Nicole; Dunn, Susan K; Marschner, Susanne; Reddy, Heather L; Goodrich, Raymond P (2011. ) In vivo viability of stored red blood cells derived from riboflavin plus ultraviolet light-treated whole blood.Transfusion, , 51 (7 ) ,1460-8 More Information

Cancelas, Jose A (2011. ) Adhesion, migration, and homing of murine hematopoietic stem cells and progenitors.Methods in molecular biology (Clifton, N.J.), , 750 ,187-96 More Information

Cardigan, R; Van der Meer, P F; Pergande, C; Cookson, P; Baumann-Baretti, B; Cancelas, J A; Devine, D; Gulliksson, H; Vassallo, R; de Wildt-Eggen, J (2011. ) Coagulation factor content of plasma produced from whole blood stored for 24 hours at ambient temperature: results from an international multicenter BEST Collaborative study.Transfusion, , 51 Suppl 1 ,50S-57S More Information

Sengupta, Amitava; Cancelas, Jose A (2010. ) Cancer stem cells: a stride towards cancer cure?.Journal of cellular physiology, , 225 (1 ) ,7-14 More Information

Yamada, Yoshiyuki; Cancelas, Jose A; Rothenberg, Marc E (2009. ) Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia.International archives of allergy and immunology, , 149 Suppl 1 ,102-7 More Information

Yamada, Yoshiyuki; Sanchez-Aguilera, Abel; Brandt, Eric B; McBride, Melissa; Al-Moamen, Nabeel J H; Finkelman, Fred D; Williams, David A; Cancelas, Jose A; Rothenberg, Marc E (2008. ) FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome.Blood, , 112 (6 ) ,2500-7 More Information

Thomas, Emily K; Cancelas, Jose A; Chae, Hee-Don; Cox, Adrienne D; Keller, Patricia J; Perrotti, Danilo; Neviani, Paolo; Druker, Brian J; Setchell, Kenneth D R; Zheng, Yi; Harris, Chad E; Williams, David A (2007. ) Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.Cancer cell, , 12 (5 ) ,467-78 More Information

Presley, Cynthia A; Lee, Andrew W; Kastl, Bryan; Igbinosa, Irogue; Yamada, Yoshiyuki; Fishman, Glenn I; Gutstein, David E; Cancelas, Jose A Bone marrow connexin-43 expression is critical for hematopoietic regeneration after chemotherapy.Cell communication & adhesion, , 12 (5-6 ) ,307-17 More Information

Puig, T; Kádár, E; Limón, A; Cancelas, J A; Eixarch, H; Luquín, L; García, M; Barquinero, J (2002. ) Myeloablation enhances engraftment of transduced murine hematopoietic cells, but does not influence long-term expression of the transgene.Gene therapy, , 9 (21 ) ,1472-9 More Information

Cancelas, J A; Koevoet, W L; de Koning, A E; Mayen, A E; Rombouts, E J; Ploemacher, R E (2000. ) Connexin-43 gap junctions are involved in multiconnexin-expressing stromal support of hemopoietic progenitors and stem cells. Blood, , 96 (2 ) ,498-505

Capmany, G; Querol, S; Cancelas, J A; García, J (1999. ) Short-term, serum-free, static culture of cord blood-derived CD34+ cells: effects of FLT3-L and MIP-1alpha on in vitro expansion of hematopoietic progenitor cells. Haematologica, , 84 (8 ) ,675-82

Canals, C; Torrico, C; Picón, M; Amill, B; Cancelas, J A; Fraga, G; Badell, I; Cubells, J; Olivé, T; Ortega, J; Vivancos, P; García, J (1997. ) Immunomagnetic bone marrow purging in children with acute lymphoblastic leukemia. Journal of hematotherapy, , 6 (3 ) ,261-8

Lopez-Jimenez, J; Cancelas, J A; Valiño, J M; Garcia-Laraña, J; Garcia-Avello, A; Arranz, M I; Perez-Oteyza, J; Ramos, P; Odriozola, J (1994. ) Effects of oral pentoxifylline on TNF-alpha levels, transplant-related toxicities and engraftment after bone marrow transplantation. Bone marrow transplantation, , 14 (6 ) ,1011-2

Cancelas, J A; García-Avello, A; García-Frade, L J (1994. ) High plasma levels of plasminogen activator inhibitor 1 (PAI-1) in polycythemia vera and essential thrombocythemia are associated with thrombosis. Thrombosis research, , 75 (5 ) ,513-20

Cancelas, J A; Hernández-Jodra, M; Zamora, C; Perez-Oteyza, J; Brieva, J A; Roldan, E; Navas, G; Garcia-Laraña, J; Lopez, J; Odriozola, J (1994. ) Circulating stem cell collection in lymphoma and myeloma after mobilization with cyclophosphamide and granulocyte colony-stimulating factor for autologous transplantation. Vox sanguinis, , 67 (4 ) ,362-7

Perez-Oteyza, J; Roldan, E; Brieva, J A; Cancelas, J A; Garcia-Larana, J; Odriozola, J; Hernandez Jodra, M; Navarro, J L (1992. ) Expression of phosphatidylinositol anchored membrane proteins in paroxysmal nocturnal haemoglobinuria after bone marrow transplantation. Bone marrow transplantation, , 10 (3 ) ,297-9

Raman, R; Kumar, R S; Hinge, A; Kumar, S; Nayak, R; Xu, J; Szczur, K; Cancelas, J A; Filippi, M-D (2013. ) p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.Leukemia, , 27 (11 ) ,2209-19 More Information

Mayes, Debra A; Rizvi, Tilat A; Titus-Mitchell, Haley; Oberst, Rachel; Ciraolo, Georgianne M; Vorhees, Charles V; Robinson, Andrew P; Miller, Stephen D; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Ratner, Nancy (2013. ) Nf1 loss and Ras hyperactivation in oligodendrocytes induce NOS-driven defects in myelin and vasculature.Cell reports, , 4 (6 ) ,1197-212 More Information

Prada, Carlos E; Jousma, Edwin; Rizvi, Tilat A; Wu, Jianqiang; Dunn, R Scott; Mayes, Debra A; Cancelas, Jose A; Dombi, Eva; Kim, Mi-Ok; West, Brian L; Bollag, Gideon; Ratner, Nancy (2013. ) Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.Acta neuropathologica, , 125 (1 ) ,159-68 More Information

Taniguchi Ishikawa, E; Chang, K H; Nayak, R; Olsson, H A; Ficker, A M; Dunn, S K; Madhu, M N; Sengupta, A; Whitsett, J A; Grimes, H L; Cancelas, J A (2013. ) Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated ?1/?2-integrin trafficking.Nature communications, , 4 ,1660 More Information

Chang, Kyung Hee; Sanchez-Aguilera, Abel; Shen, Shuhong; Sengupta, Amitava; Madhu, Malav N; Ficker, Ashley M; Dunn, Susan K; Kuenzi, Ashley M; Arnett, Jorden L; Santho, Rebecca A; Agirre, Xabier; Perentesis, John P; Deininger, Michael W; Zheng, Yi; Bustelo, Xose R; Williams, David A; Cancelas, Jose A (2012. ) Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.Blood, , 120 (4 ) ,800-11 More Information

Geiger, Hartmut; Pawar, Snehalata A; Kerschen, Edward J; Nattamai, Kalpana J; Hernandez, Irene; Liang, Hai Po H; Fernández, Jose Á; Cancelas, Jose A; Ryan, Marnie A; Kustikova, Olga; Schambach, Axel; Fu, Qiang; Wang, Junru; Fink, Louis M; Petersen, Karl-Uwe; Zhou, Daohong; Griffin, John H; Baum, Christopher; Weiler, Hartmut; Hauer-Jensen, Martin (2012. ) Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.Nature medicine, , 18 (7 ) ,1123-9 More Information

Sengupta, Amitava; Ficker, Ashley M; Dunn, Susan K; Madhu, Malav; Cancelas, Jose A (2012. ) Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells.Blood, , 119 (2 ) ,494-502 More Information

Cancelas, Jose A; Rugg, Neeta; Pratt, P Gayle; Worsham, D Nicole; Pehta, Joan C; Banks, Kate; Davenport, Robertson D; Judd, W John (2011. ) Infusion of P-Capt prion-filtered red blood cell products demonstrate acceptable in vivo viability and no evidence of neoantigen formation.Transfusion, , 51 (10 ) ,2228-36 More Information

Ryan, Marnie A; Nattamai, Kalpana J; Xing, Ellen; Schleimer, David; Daria, Deidre; Sengupta, Amitava; Köhler, Anja; Liu, Wei; Gunzer, Matthias; Jansen, Michael; Ratner, Nancy; Le Cras, Timothy D; Waterstrat, Amanda; Van Zant, Gary; Cancelas, Jose A; Zheng, Yi; Geiger, Hartmut (2010. ) Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.Nature medicine, , 16 (10 ) ,1141-6 More Information

Sengupta, Amitava; Arnett, Jorden; Dunn, Susan; Williams, David A; Cancelas, Jose A (2010. ) Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.Blood, , 116 (1 ) ,81-4 More Information

Kalfa, Theodosia A; Pushkaran, Suvarnamala; Zhang, Xiaoling; Johnson, James F; Pan, Dao; Daria, Deidre; Geiger, Hartmut; Cancelas, Jose A; Williams, David A; Zheng, Yi (2010. ) Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.Haematologica, , 95 (1 ) ,27-35 More Information

Yamada, Yoshiyuki; Cancelas, Jose A (2010. ) FIP1L1/PDGFR alpha-associated systemic mastocytosis.International archives of allergy and immunology, , 152 Suppl 1 ,101-5 More Information

Cancelas, Jose A; Williams, David A (2009. ) Rho GTPases in hematopoietic stem cell functions.Current opinion in hematology, , 16 (4 ) ,249-54 More Information

Milsom, Michael D; Lee, Andrew W; Zheng, Yi; Cancelas, Jose A (2009. ) Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766.Haematologica, , 94 (7 ) ,1011-5 More Information

Mahller, Yonatan Y; Williams, Jon P; Baird, William H; Mitton, Bryan; Grossheim, Jonathan; Saeki, Yoshinaga; Cancelas, Jose A; Ratner, Nancy; Cripe, Timothy P (2009. ) Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus.PloS one, , 4 (1 ) ,e4235 More Information

Thomas, E K; Cancelas, J A; Zheng, Y; Williams, D A (2008. ) Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.Leukemia, , 22 (5 ) ,898-904 More Information

Mahller, Yonatan Y; Vaikunth, Sachin S; Ripberger, Maria C; Baird, William H; Saeki, Yoshinaga; Cancelas, Jose A; Crombleholme, Timothy M; Cripe, Timothy P (2008. ) Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.Cancer research, , 68 (4 ) ,1170-9 More Information

Wu, Jianqiang; Williams, Jon P; Rizvi, Tilat A; Kordich, Jennifer J; Witte, David; Meijer, Dies; Stemmer-Rachamimov, Anat O; Cancelas, Jose A; Ratner, Nancy (2008. ) Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.Cancer cell, , 13 (2 ) ,105-16 More Information

Williams, David A; Cancelas, Jose A (2006. ) Leukaemia: niche retreats for stem cells.Nature, , 444 (7121 ) ,827-8 More Information

Williams, David A; Xu, Haiming; Cancelas, Jose A (2006. ) Children are not little adults: just ask their hematopoietic stem cells.The Journal of clinical investigation, , 116 (10 ) ,2593-6 More Information

Cancelas, Jose A; Jansen, Michael; Williams, David A (2006. ) The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization.Experimental hematology, , 34 (8 ) ,976-85 More Information

Cancelas, Jose A; Williams, David A (2006. ) Stem cell mobilization by beta2-agonists.Nature medicine, , 12 (3 ) ,278-9 More Information

Risques, R A; Moreno, V; Marcuello, E; Petriz, J; Cancelas, J A; Sancho, F J; Torregrosa, A; Capella, G; Peinado, M A (2001. ) Redefining the significance of aneuploidy in the prognostic assessment of colorectal cancer. Laboratory investigation; a journal of technical methods and pathology, , 81 (3 ) ,307-15

Petit, J; Boqué, C; Cancelas, J A; Sarrà, J; Muñoz, J; Garcia, J; Grañena, A (1999. ) Feasibility of ESHAP + G-CSF as peripheral blood hematopoietic progenitor cell mobilisation regimen in resistant and relapsed lymphoma: a single-center study of 22 patients.Leukemia & lymphoma, , 34 (1-2 ) ,119-27 More Information

Salazar, R; Solá, C; Maroto, P; Tabernero, J M; Brunet, J; Verger, G; Valentí, V; Cancelas, J A; Ojeda, B; Mendoza, L; Rodríguez, M; Montesinos, J; López-López, J J (1999. ) Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation.Bone marrow transplantation, , 23 (1 ) ,27-33 More Information

Solá, C.; Maroto, P.; Salazar, R.; Mesía, R.; Mendoza, L.; Brunet, J.; López-Pousa, A.; Tabernero, J. M.; Montesinos, J.; Pericay, C.; Martínez, C.; Cancelas, J. A.; López-López, J. J. (1999. ) Bone Marrow Transplantation: Prognostic Factors of Peripheral Blood Stem Cell Mobilization with Cyclophosphamide and Filgrastim (r-metHuG-CSF): The CD34+ Cell Dose Positively Affects the Time to Hematopoietic Recovery and Supportive Requirements after High-Dose Chemotherapy. Hematology (Amsterdam, Netherlands), , 4 (3 ) ,195-209

Cancelas, J A; Querol, S; Canals, C; Picón, M; Azqueta, C; Solà, C; Montes, A; Amill, B; Griera, E; Inglés, J; López, J J; Germà, J R; García-López, J Peripheral blood CD34+ cell immunomagnetic selection in breast cancer patients: effect on hematopoietic progenitor content and hematologic recovery after high-dose chemotherapy and autotransplantation. Transfusion, , 38 (11-12 ) ,1063-70

Cancelas, J A; Querol, S; Canals, C; Bertran, J; Limon, A; Amill, B; Petriz, J; Garcia-Lopez, J (1995. ) CD34+ cell positive selection from mobilized peripheral blood by an indirect immunomagnetic method: effect of the type of mobilization and assessment of tumor depletion ability. Journal of hematotherapy, , 4 (6 ) ,531-8

Cancelas, J A; López-Jiménez, J; González, C; Calbo, M A; García Laraña, J (1994. ) [Cerebral toxoplasmosis with atypical presentation in a bone marrow transplant patient]. Medicina clínica, , 103 (10 ) ,383-4

Cancelas, J A; Lopez, J; Cabezudo, E; Navas, E; Garcia Laraña, J; Jimenez Mena, M; Diz, P; Perez de Oteyza, J; Villalon, L; Sanchez-Sousa, A (1994. ) Native valve endocarditis due to Candida parapsilosis: a late complication after bone marrow transplantation-related fungemia. Bone marrow transplantation, , 13 (3 ) ,333-4

Dumont, Larry J; Cancelas, Jose A; Maes, Lou Ann; Rugg, Neeta; Whitley, Pamela; Herschel, Louise; Siegel, Alan H; Szczepiorkowski, Zbigniew M; Hess, John R; Zia, Majid (2015. ) The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh-frozen plasma prepared within eight hours of collection.Transfusion, , 55 (3 ) ,476-84 More Information

Guo, Fukun; Zhang, Shuangmin; Grogg, Matthew; Cancelas, Jose A; Varney, Melinda E; Starczynowski, Daniel T; Du, Wei; Yang, Jun-Qi; Liu, Wei; Thomas, George; Kozma, Sara; Pang, Qishen; Zheng, Yi (2013. ) Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis.Haematologica, , 98 (9 ) ,1353-8 More Information

Konstantinidis, Diamantis G; Pushkaran, Suvarnamala; Johnson, James F; Cancelas, Jose A; Manganaris, Stefanos; Harris, Chad E; Williams, David A; Zheng, Yi; Kalfa, Theodosia A (2012. ) Signaling and cytoskeletal requirements in erythroblast enucleation.Blood, , 119 (25 ) ,6118-27 More Information

Sengupta, Amitava; Duran, Angeles; Ishikawa, Eri; Florian, Maria Carolina; Dunn, Susan K; Ficker, Ashley M; Leitges, Michael; Geiger, Hartmut; Diaz-Meco, Maria; Moscat, Jorge; Cancelas, Jose A (2011. ) Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation.Proceedings of the National Academy of Sciences of the United States of America, , 108 (24 ) ,9957-62 More Information

van der Meer, Pieter F; Cancelas, Jose A; Vassallo, Ralph R; Rugg, Neeta; Einarson, Mindy; Hess, John R (2011. ) Evaluation of the overnight hold of whole blood at room temperature, before component processing: platelets (PLTs) from PLT-rich plasma.Transfusion, , 51 Suppl 1 ,45S-49S More Information

van der Meer, Pieter F; Cancelas, Jose A; Cardigan, Rebecca; Devine, Dana V; Gulliksson, Hans; Sparrow, Rosemary L; Vassallo, Ralph R; de Wildt-Eggen, Janny; Baumann-Baretti, Bärbel; Hess, John R (2011. ) Evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (RBC) additive solutions on in vitro RBC measures.Transfusion, , 51 Suppl 1 ,15S-24S More Information

Yang, Linda; Wang, Lei; Kalfa, Theodosia A; Cancelas, Jose A; Shang, Xun; Pushkaran, Suvarnamala; Mo, Jun; Williams, David A; Zheng, Yi (2007. ) Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.Blood, , 110 (12 ) ,3853-61 More Information

Yang, Linda; Wang, Lei; Geiger, Hartmut; Cancelas, Jose A; Mo, Jun; Zheng, Yi (2007. ) Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.Proceedings of the National Academy of Sciences of the United States of America, , 104 (12 ) ,5091-6 More Information

Yamada, Yoshiyuki; Rothenberg, Marc E; Lee, Andrew W; Akei, Hiroko Saito; Brandt, Eric B; Williams, David A; Cancelas, Jose A (2006. ) The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease.Blood, , 107 (10 ) ,4071-9 More Information

Jansen, Michael; Yang, Feng-Chun; Cancelas, José A; Bailey, Jeff R; Williams, David A (2005. ) Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure.Stem cells (Dayton, Ohio), , 23 (3 ) ,335-46 More Information

Gu, Yi; Filippi, Marie-Dominique; Cancelas, Jose A; Siefring, Jamie E; Williams, Emily P; Jasti, Aparna C; Harris, Chad E; Lee, Andrew W; Prabhakar, Rethinasamy; Atkinson, Simon J; Kwiatkowski, David J; Williams, David A (2003. ) Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.Science (New York, N.Y.), , 302 (5644 ) ,445-9 More Information

Boqué, C; Petit, J; Sarrá, J; Cancelas, J A; Muñoz, J; Español, J I; de la Banda, E; Aventin, A; Berlanga, J; Ferrá, C; Amill, B; Torrico, C; Azqueta, C; Llucià, M; García, J; Grañena, A (1996. ) Mobilization of peripheral stem cells with intensive chemotherapy (ICE regimen) and G-CSF in chronic myeloid leukemia. Bone marrow transplantation, , 18 (5 ) ,879-84

Gasilina, Anjelika; Premnauth, Gurdat; Gurjar, Purujit; Biesiada, Jacek; Hegde, Shailaja; Milewski, David; Ma, Gang; Kalin, Tanya V; Merino, Edward; Meller, Jarek; Seibel, William; Cancelas, José A; Vinnedge, Lisa Privette; Nassar, Nicolas N (2020. ) IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.PloS one, , 15 (3 ) ,e0229801 More Information

D?Alessandro, Angelo; Yoshida, Tatsuro; Nestheide, Shawnagay; Nemkov, Travis; Stocker, Sarah; Stefanoni, Davide; Mohmoud, Fatima; Rugg, Neeta; Dunham, Andrew; Cancelas, Jose A (2020. ) Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery.Transfusion, , More Information

Singh, Abhishek K; Cancelas, Jose A (2020. ) Gap Junctions in the Bone Marrow Lympho-Hematopoietic Stem Cell Niche, Leukemia Progression, and Chemoresistance.International journal of molecular sciences, , 21 (3 ) , More Information

Yu, Yanan; Choi, Kwangmin; Wu, Jianqiang; Andreassen, Paul R; Dexheimer, Phillip J; Keddache, Mehdi; Brems, Hilde; Spinner, Robert J; Cancelas, Jose A; Martin, Lisa J; Wallace, Margaret R; Legius, Eric; Vogel, Kristine S; Ratner, Nancy (2020. ) NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation.Acta neuropathologica, , 139 (1 ) ,157-174 More Information

Boucher, Alexander A; Luchtman-Jones, Lori; Palumbo, Joseph S; Cancelas, Jose A; Abu-El-Haija, Maisam; Jenkins, Todd M; Lin, Tom K; Nathan, Jaimie D (2019. ) Extreme Thrombocytosis after Pediatric Pancreatectomy with Islet Autotransplantation Is Unique Compared to Other Postsplenectomy States.Journal of pediatric surgery, , More Information

Nayak, Ramesh C; Cancelas, Jose A (2019. ) Ubiquitination is not omnipresent in myeloid leukemia.Haematologica, , 104 (9 ) ,1694-1696 More Information

Trump, Lisa R; Nayak, Ramesh C; Singh, Abhishek K; Emberesh, Sana; Wellendorf, Ashley M; Lutzko, Carolyn M; Cancelas, Jose A (2019. ) Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.Stem cells translational medicine, , 8 (6 ) ,557-567 More Information

Cancelas, Jose A (2019. ) Future of platelet formulations with improved clotting profile: a short review on human safety and efficacy data.Transfusion, , 59 (S2 ) ,1467-1473 More Information

Nayak, R C; Hegde, S; Althoff, M J; Wellendorf, A M; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, M T; Moscat, J; Cancelas, J A (2019. ) The signaling axis atypical protein kinase C ?/?-Satb2 mediates leukemic transformation of B-cell progenitors.Nature communications, , 10 (1 ) ,46 More Information

Niu, Haixia; Cancelas, Jose A (2018. ) Twisting the bone marrow stem cell niche.Haematologica, , 103 (12 ) ,1937-1939 More Information

Hegde, Shailaja; Akbar, Huzoor; Zheng, Yi; Cancelas, Jose A (2018. ) Towards increasing shelf life and haemostatic potency of stored platelet concentrates.Current opinion in hematology, , 25 (6 ) ,500-508 More Information

Slichter, Sherrill J; Dumont, Larry J; Cancelas, Jose A; Jones, MeLinh; Gernsheimer, Terry B; Szczepiorkowski, Zbigniew M; Dunbar, Nancy M; Prakash, Gautham; Medlin, Stephen; Rugg, Neeta; Kinne, Bridget; Macdonald, Victor W; Housler, Greggory; Valiyaveettil, Manoj; Hmel, Peter; Ransom, Janet H (2018. ) Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia.Transfusion, , 58 (9 ) ,2129-2138 More Information

Mock, Donald M; Nalbant, Demet; Kyosseva, Svetlana V; Schmidt, Robert L; An, Guohua; Matthews, Nell I; Vlaar, Alexander P J; van Bruggen, Robin; de Korte, Dirk; Strauss, Ronald G; Cancelas, José A; Franco, Robert S; Veng-Pedersen, Peter; Widness, John A (2018. ) Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations.Transfusion, , 58 (8 ) ,2068-2081 More Information

Zhang, Cuiping; D'Alessandro, Angelo; Wellendorf, Ashley M; Mohmoud, Fatima; Serrano-Lopez, Juana; Perentesis, John P; Komurov, Kakajan; Alexe, Gabriela; Stegmaier, Kimberly; Whitsett, Jeffrey A; Grimes, H Leighton; Cancelas, Jose A (2018. ) KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia.Oncotarget, , 9 (51 ) ,29665-29679 More Information

Roy, Swarnava; Rai, Parul; Eiymo Mwa Mpollo, Marthe-Sandrine; Chang, Kyung-Hee; Rizvi, Tilat; Shanmukhappa, Shiva Kumar; VandenHeuvel, Katherine; Aronow, Bruce; Inagami, Tadashi; Cancelas, Jose A; Malik, Punam (2018. ) Angiotensin receptor signaling in sickle cell anemia has a reno-protective effect on urine concentrating ability but results in sickle glomerulopathy.American journal of hematology, , 93 (7 ) ,E177-E181 More Information

Singh, Abhishek K; Althoff, Mark J; Cancelas, Jose A (2018. ) Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging.Current stem cell reports, , 4 (2 ) ,166-181 More Information

Serrano-Lopez, Juana; Nattamai, Kalpana; Pease, Nicholas A; Shephard, Miranda S; Wellendorf, Ashley M; Sertorio, Mathieu; Smith, Eric A; Geiger, Hartmut; Wells, Susanne I; Cancelas, Jose A; Privette Vinnedge, Lisa M (2018. ) Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.Experimental hematology, , 59 ,40-50.e3 More Information

Lee, Jung-Mi; Govindarajah, Vinothini; Goddard, Bryan; Hinge, Ashwini; Muench, David E; Filippi, Marie-Dominique; Aronow, Bruce; Cancelas, Jose A; Salomonis, Nathan; Grimes, H Leighton; Reynaud, Damien (2018. ) Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression.The Journal of experimental medicine, , 215 (2 ) ,627-644 More Information

Nalbant, Demet; Cancelas, José A; Mock, Donald M; Kyosseva, Svetlana V; Schmidt, Robert L; Cress, Gretchen A; Zimmerman, M Bridget; Strauss, Ronald G; Widness, John A (2018. ) In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage.Transfusion, , 58 (2 ) ,352-358 More Information

Fang, Jing; Muto, Tomoya; Kleppe, Maria; Bolanos, Lyndsey C; Hueneman, Kathleen M; Walker, Callum S; Sampson, Leesa; Wellendorf, Ashley M; Chetal, Kashish; Choi, Kwangmin; Salomonis, Nathan; Choi, Yongwon; Zheng, Yi; Cancelas, Jose A; Levine, Ross L; Starczynowski, Daniel T (2018. ) TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis.Cell reports, , 22 (5 ) ,1250-1262 More Information

Wang, Jieyu; Hayashi, Yoshihiro; Yokota, Asumi; Xu, Zefeng; Zhang, Yue; Huang, Rui; Yan, Xiaomei; Liu, Hongyun; Ma, Liping; Azam, Mohammad; Bridges, James P; Cancelas, Jose A; Kalfa, Theodosia A; An, Xiuli; Xiao, Zhijian; Huang, Gang (2018. ) Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.Haematologica, , 103 (1 ) ,40-50 More Information

Noel, John G; Ramser, Benjamin J; Cancelas, Jose A; McCormack, Francis X; Gardner, Jason C (2017. ) Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice.Experimental hematology, , 56 ,16-30 More Information

Worsham, D Nicole; Reems, Jo-Anna; Szczepiorkowski, Zbigniew M; McKenna, David H; Leemhuis, Thomas; Mathew, Aby J; Cancelas, Jose A (2017. ) Clinical methods of cryopreservation for donor lymphocyte infusions vary in their ability to preserve functional T-cell subpopulations.Transfusion, , 57 (6 ) ,1555-1565 More Information

Schmidt, Robert L; Mock, Donald M; Franco, Robert S; Cohen, Robert M; North, Anne K; Cancelas, José A; Geisen, Christof; Strauss, Ronald G; Vlaar, Alexander P; Nalbant, Demet; Widness, John A (2017. ) Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.Transfusion, , 57 (6 ) ,1488-1496 More Information

Guidi, Novella; Sacma, Mehmet; Ständker, Ludger; Soller, Karin; Marka, Gina; Eiwen, Karina; Weiss, Johannes M; Kirchhoff, Frank; Weil, Tanja; Cancelas, Jose A; Florian, Maria Carolina; Geiger, Hartmut (2017. ) Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.The EMBO journal, , 36 (10 ) ,1463 More Information

Cancelas, Jose A; Slichter, Sherrill J; Rugg, Neeta; Pratt, P Gayle; Nestheide, Shawnagay; Corson, Jill; Pellham, Esther; Huntington, Marty; Goodrich, Raymond P (2017. ) Red blood cells derived from whole blood treated with riboflavin and ultraviolet light maintain adequate survival in vivo after 21 days of storage.Transfusion, , 57 (5 ) ,1218-1225 More Information

Guidi, Novella; Sacma, Mehmet; Ständker, Ludger; Soller, Karin; Marka, Gina; Eiwen, Karina; Weiss, Johannes M; Kirchhoff, Frank; Weil, Tanja; Cancelas, Jose A; Florian, Maria Carolina; Geiger, Hartmut (2017. ) Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells.The EMBO journal, , 36 (7 ) ,840-853 More Information

Kesarwani, Meenu; Kincaid, Zachary; Gomaa, Ahmed; Huber, Erika; Rohrabaugh, Sara; Siddiqui, Zain; Bouso, Muhammad F; Latif, Tahir; Xu, Ming; Komurov, Kakajan; Mulloy, James C; Cancelas, Jose A; Grimes, H Leighton; Azam, Mohammad (2017. ) Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.Nature medicine, , 23 (4 ) ,472-482 More Information

Cancelas, J A; Gottschall, J L; Rugg, N; Graminske, S; Schott, M A; North, A; Huang, N; Mufti, N; Erickson, A; Rico, S; Corash, L (2017. ) Red blood cell concentrates treated with the amustaline (S-303) pathogen reduction system and stored for 35 days retain post-transfusion viability: results of a two-centre study.Vox sanguinis, , 112 (3 ) ,210-218 More Information

Daily, Kenneth; Ho Sui, Shannan J; Schriml, Lynn M; Dexheimer, Phillip J; Salomonis, Nathan; Schroll, Robin; Bush, Stacy; Keddache, Mehdi; Mayhew, Christopher; Lotia, Samad; Perumal, Thanneer M; Dang, Kristen; Pantano, Lorena; Pico, Alexander R; Grassman, Elke; Nordling, Diana; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Lutzko, Carolyn; Aronow, Bruce J; Omberg, Larsson (2017. ) Molecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives.Scientific data, , 4 ,170030 More Information

Choi, Kwangmin; Komurov, Kakajan; Fletcher, Jonathan S; Jousma, Edwin; Cancelas, Jose A; Wu, Jianqiang; Ratner, Nancy (2017. ) An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system.Scientific reports, , 7 ,43315 More Information

Cancelas, Jose A; Rugg, Neeta; Nestheide, Shawnagay; Hill, Sarah E; Emanuele, R Martin; Mckenzie, Douglas S (2017. ) The purified vepoloxamer prevents haemolysis in 42-day stored, DEHP/PVC-free red blood cell units.Blood transfusion = Trasfusione del sangue, , 15 (2 ) ,165-171 More Information

Cancelas, Jose A; Scott, Edward P; Bill, Jerome R (2016. ) Continuous CD34+ cell collection by a new device is safe and more efficient than by a standard collection procedure: results of a two-center, crossover, randomized trial.Transfusion, , 56 (11 ) ,2824-2832 More Information

Cancelas, Jose A; Rugg, Neeta (2016. ) Plasma Protein Timings: Relative Contributions of Storage Time, Donor Age and Donation Season.EBioMedicine, , 12 ,32-33 More Information

Hegde, Shailaja; Cancelas, Jose A (2016. ) Dissecting the metabolic pathways controlling platelet survival in vivo: are our platelets what they eat?.Transfusion, , 56 (8 ) ,1928-31 More Information

Salomonis, Nathan; Dexheimer, Phillip J; Omberg, Larsson; Schroll, Robin; Bush, Stacy; Huo, Jeffrey; Schriml, Lynn; Ho Sui, Shannan; Keddache, Mehdi; Mayhew, Christopher; Shanmukhappa, Shiva Kumar; Wells, James; Daily, Kenneth; Hubler, Shane; Wang, Yuliang; Zambidis, Elias; Margolin, Adam; Hide, Winston; Hatzopoulos, Antonis K; Malik, Punam; Cancelas, Jose A; Aronow, Bruce J; Lutzko, Carolyn (2016. ) Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium.Stem cell reports, , 7 (1 ) ,110-25 More Information

Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy (2016. ) Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation.Cell reports, , 14 (8 ) ,1979-90 More Information

Serrano-Lopez, Juana; Cancelas, Jose A (2016. ) Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence.Cell stem cell, , 18 (2 ) ,158-60 More Information

Cancelas, Jose A (2015. ) Granulocyte transfusion: questions remain.Blood, , 126 (18 ) ,2082-3 More Information

Nayak, Ramesh C; Trump, Lisa R; Aronow, Bruce J; Myers, Kasiani; Mehta, Parinda; Kalfa, Theodosia; Wellendorf, Ashley M; Valencia, C Alexander; Paddison, Patrick J; Horwitz, Marshall S; Grimes, H Leighton; Lutzko, Carolyn; Cancelas, Jose A (2015. ) Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.The Journal of clinical investigation, , 125 (8 ) ,3103-16 More Information

González-Nieto, Daniel; Chang, Kyung-Hee; Fasciani, Ilaria; Nayak, Ramesh; Fernandez-García, Laura; Barrio, Luis C; Cancelas, José A (2015. ) Connexins: Intercellular Signal Transmitters in Lymphohematopoietic Tissues.International review of cell and molecular biology, , 318 ,27-62 More Information

cancelas j

cancelas j

Golan, Karin; Singh, Abhishek K; Kollet, Orit; Bertagna, Mayla; Althoff, Mark J; Khatib-Massalha, Eman; Petrovich-Kopitman, Ekaterina; Wellendorf, Ashley M; Massalha, Hassan; Levin-Zaidman, Smadar; Dadosh, Tali; Bohan, Breanna; V Gawali, Mruniya; Dasgupta, Biplab; Lapidot, Tsvee; Cancelas, Jose A (2020. ) Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma.Blood, , 136 (23 ) ,2607-2619 More Information

Hegde, Shailaja; Wellendorf, Ashley M; Zheng, Yi; Cancelas, Jose A (2020. ) Antioxidant prevents clearance of hemostatically competent platelets after long-term cold storage.Transfusion, , More Information

Nelson, Adam S; Heyenbruch, Daria; Rubinstein, Jeremy D; Sabulski, Anthony; Jodele, Sonata; Thomas, Shawn; Lutzko, Carolyn; Zhu, Xiang; Leemhuis, Thomas; Cancelas, Jose A; Keller, Michael; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S (2020. ) Virus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients.Blood advances, , 4 (22 ) ,5745-5754 More Information

Govindarajah, Vinothini; Lee, Jung-Mi; Solomon, Michael; Goddard, Bryan; Nayak, Ramesh; Nattamai, Kalpana; Geiger, Hartmut; Salomonis, Nathan; Cancelas, Jose A; Reynaud, Damien (2020. ) FOXO activity adaptation safeguards the hematopoietic stem cell compartment in hyperglycemia.Blood advances, , 4 (21 ) ,5512-5526 More Information

Althoff, Mark J; Nayak, Ramesh C; Hegde, Shailaja; Wellendorf, Ashley M; Bohan, Breanna; Filippi, Marie-Dominique; Xin, Mei; Lu, Q Richard; Geiger, Hartmut; Zheng, Yi; Diaz-Meco, Maria T; Moscat, Jorge; Cancelas, Jose A (2020. ) Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.Blood, , 136 (16 ) ,1824-1836 More Information

Kelly, Kathleen; Cancelas, Jose A; Szczepiorkowski, Zbigniew M; Dumont, Deborah F; Rugg, Neeta; Dumont, Larry J (2020. ) Frozen Platelets-Development and Future Directions.Transfusion medicine reviews, , 34 (4 ) ,286-293 More Information

Rubinstein, Jeremy D; Zhu, Xiang; Lutzko, Carolyn; Leemhuis, Tom; Cancelas, Jose A; Jodele, Sonata; Bollard, Catherine M; Hanley, Patrick J; Davies, Stella M; Grimley, Michael S; Nelson, Adam S (2020. ) Complement inhibition does not impair the clinical antiviral capabilities of virus-specific T-cell therapy.Blood advances, , 4 (14 ) ,3252-3257 More Information

cancelas j or cancelas perez and not malaisse

Fan, Yuping; Teng, Yan; Loison, Fabien; Pang, Aiming; Kasorn, Anongnard; Shao, Xinqi; Zhang, Cunling; Ren, Qian; Yu, Hongbo; Zheng, Yi; Cancelas, Jose A; Manis, John; Chai, Li; Park, Shin-Young; Zhao, Li; Xu, Yuanfu; Feng, Sizhou; Silberstein, Leslie E; Ma, Fengxia; Luo, Hongbo R (2021. ) Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion.Science translational medicine, , 13 (604 ) , More Information

Adori, Csaba; Daraio, Teresa; Kuiper, Raoul; Barde, Swapnali; Horvathova, Lubica; Yoshitake, Takashi; Ihnatko, Robert; Valladolid-Acebes, Ismael; Vercruysse, Pauline; Wellendorf, Ashley M; Gramignoli, Roberto; Bozoky, Bela; Kehr, Jan; Theodorsson, Elvar; Cancelas, Jose A; Mravec, Boris; Jorns, Carl; Ellis, Ewa; Mulder, Jan; Uhlén, Mathias; Bark, Christina; Hökfelt, Tomas (2021. ) Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.Science advances, , 7 (30 ) , More Information

Davis, Greg; York, Allen J; Bacon, Willis Clark; Lin, Suh-Chin; McNeal, Monica Malone; Yarawsky, Alexander E; Maciag, Joseph J; Miller, Jeanette L C; Locker, Kathryn C S; Bailey, Michelle; Stone, Rebecca; Hall, Michael; Gonzalez, Judith; Sproles, Alyssa; Woodle, E Steve; Safier, Kristen; Justus, Kristine A; Spearman, Paul; Ware, Russell E; Cancelas, Jose A; Jordan, Michael B; Herr, Andrew B; Hildeman, David A; Molkentin, Jeffery D (2021. ) Seroprevalence of SARS-CoV-2 infection in Cincinnati Ohio USA from August to December 2020.PloS one, , 16 (7 ) ,e0254667 More Information

Serrano-Lopez, Juana; Hegde, Shailaja; Kumar, Sachin; Serrano, Josefina; Fang, Jing; Wellendorf, Ashley M; Roche, Paul A; Rangel, Yamileth; Carrington, Leolene J; Geiger, Hartmut; Grimes, H Leighton; Luther, Sanjiv; Maillard, Ivan; Sanchez-Garcia, Joaquin; Starczynowski, Daniel T; Cancelas, Jose A (2021. ) Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.eLife, , 10 , More Information

Prus, Kristina; Alquist, Caroline R; Cancelas, Jose A; Oh, David (2021. ) Decrease in serum antibodies to SARS-CoV-2 in convalescent plasma donors over time.Transfusion, , 61 (2 ) ,651-654 More Information

Solomon M, Song B, Govindarajah V, Good S, Arasu A, Hinton EB, Thakkar K, Bartram J, Filippi M-D, Cancelas JA, Salomonis N, Grimes HL, Reynaud D (2024. ) Slow cycling and durable Flt3+ progenitors contribute to hematopoiesis under native conditions.J Exp Med, , 221 (1 ) ,320231035. More Information

Galletta TJ, Lane A, Lutzko C, Leemhuis T, Cancelas JA, Khoury R, Wang YM, Hanley PJ, Keller MD, Bollard CM, Davies SM, Grimley MS, Rubinstein JD (2023. ) Third-Party and Patient-Specific Donor-Derived Virus-Specific T Cells Demonstrate Similar Efficacy and Safety for Management of Viral Infections after Hematopoietic Stem Cell Transplantation in Children and Young Adults.Transplant Cell Ther, , 29 (5 ) ,305-310. More Information

Butler-Foster, Terrie; Khandelwal, Aditi; Montemayor, Celina; Miller, Yvette Marie; Yan, Matthew T S; Holmberg, Jerry A; Ipe, Tina S; Accooe, Philip; Cancelas, Jose A (2023. ) From MPOX to the next epidemic: Words matter when talking about equity-deserving groups.Transfusion, , 63 (3 ) ,646-651 More Information

Dandamudi, Akhila; Seibel, William; Tourdot, Benjamin; Cancelas, Jose A; Akbar, Huzoor; Zheng, Yi (2023. ) Structure-Activity Relationship Analysis of Rhosin, a RhoA GTPase Inhibitor, Reveals a New Class of Antiplatelet Agents.International journal of molecular sciences, , 24 (4 ) , More Information

Menéndez-Gutiérrez, María Piedad; Porcuna, Jesús; Nayak, Ramesh; Paredes, Ana; Niu, Haixia; Núñez, Vanessa; Paranjpe, Aditi; Gómez, Manuel J; Bhattacharjee, Anukana; Schnell, Daniel J; Sánchez-Cabo, Fátima; Welch, John S; Salomonis, Nathan; Cancelas, Jose A; Ricote, Mercedes (2023. ) Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis.Blood, , 141 (6 ) ,592-608 More Information

Hegde, Shailaja; Zheng, Yi; Cancelas, Jose A (2022. ) Novel blood derived hemostatic agents for bleeding therapy and prophylaxis.Current opinion in hematology, , 29 (6 ) ,281-289 More Information

Cancelas, Jose A (2022. ) Precision transfusion medicine: a new spin.Blood, , 140 (15 ) ,1661-1663 More Information

Cancelas, Jose A; Genthe, Jamie R; Stolla, Moritz; Rugg, Neeta; Bailey, S Lawrence; Nestheide, Shawnagay; Shaz, Beth; Mack, Samantha; Schroeder, Kadi; Anani, Waseem; Szczepiorkowski, Zbigniew M; Dumont, Larry J; Yegneswaran, Subramanian; Corash, Laurence; Mufti, Nina; Benjamin, Richard J; Erickson, Anna C (2022. ) Evaluation of amotosalen and UVA pathogen-reduced apheresis platelets after 7-day storage.Transfusion, , 62 (8 ) ,1619-1629 More Information

Vogel, Mona; Möhrle, Bettina; Sakk, Vadim; Brown, Andreas; Palmer, Annette; Braumüller, Sonja; Huber-Lang, Markus; Allgöwer, Andreas; Cancelas, Jose A; Geiger, Hartmut (2022. ) A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome.Shock (Augusta, Ga.), , 57 (6 ) ,260-267 More Information

Nayak, R C; Chang, K H; Singh, A K; Kotliar, M; Desai, M; Wellendorf, A M; Wunderlich, M; Bartram, J; Mizukawa, B; Cuadrado, M; Dexheimer, P; Barski, A; Bustelo, X R; Nassar, N N; Cancelas, J A (2022. ) Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis.Nature communications, , 13 (1 ) ,3056 More Information

Rubinstein, Jeremy D; Lutzko, Carolyn; Leemhuis, Thomas; Zhu, Xiang; Pham, Giang; Ray, Lorraine; Thomas, Shawn; Dourson, Celeste; Wilhelm, Jamie; Lane, Adam; Cancelas, Jose A; Lipps, Dakota; Ferrell, Justin; Hanley, Patrick J; Keller, Michael D; Bollard, Catherine M; Wang, YunZu M; Davies, Stella M; Nelson, Adam S; Grimley, Michael S (2022. ) Scheduled administration of virus-specific T cells for viral prophylaxis after pediatric allogeneic stem cell transplant.Blood advances, , 6 (9 ) ,2897-2907 More Information

Mock, Donald M; Stowell, Sean R; Franco, Robert S; Kyosseva, Svetlana V; Nalbant, Demet; Schmidt, Robert L; Cress, Gretchen A; Strauss, Ronald G; Cancelas, José A; von Goetz, Melissa; North, Anne K; Widness, John A (2022. ) Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival.Transfusion, , 62 (4 ) ,770-782 More Information

Patritti Cram, Jennifer; Wu, Jianqiang; Coover, Robert A; Rizvi, Tilat A; Chaney, Katherine E; Ravindran, Ramya; Cancelas, Jose A; Spinner, Robert J; Ratner, Nancy (2022. ) P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis.eLife, , 11 , More Information

Ohanian, Maro; Cancelas, Jose A; Davenport, Robertson; Pullarkat, Vinod; Hervig, Tor; Broome, Catherine; Marek, Kelly; Kelly, Mary; Gul, Zartash; Rugg, Neeta; Nestheide, Shawnagay; Kinne, Bridget; Szczepiorkowski, Zbigniew; Kantarjian, Hagop; Pehta, Joan; Biehl, Ruth; Yu, Anna; Aung, Fleur; Antebi, Ben; Fitzpatrick, Glen Michael (2022. ) Freeze-dried platelets are a promising alternative in bleeding thrombocytopenic patients with hematological malignancies.American journal of hematology, , 97 (3 ) ,256-266 More Information

Hegde, Shailaja; Gasilina, Anjelika; Wunderlich, Mark; Lin, Yuan; Buchholzer, Marcel; Krumbach, Oliver H F; Akbarzadeh, Mohammad; Ahmadian, Mohammad Reza; Seibel, William; Zheng, Yi; Perentesis, John P; Mizukawa, Benjamin E; Vinnedge, Lisa Privette; Cancelas, José A; Nassar, Nicolas N (2022. ) Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.Leukemia, , 36 (3 ) ,637-647 More Information

Cancelas, Jose A; Nestheide, Shawnagay; Rugg, Neeta; Eckerman, Anna; Macdonald, Victor W; L Charles, Matthew; Markstrom, Luke; Atkinson, Andrew J; King, Melissa R; Snyder, Michele; Burgess, David; Murto, James; Valiyaveettil, Manoj K; C Pehta, Joan; Penegor, Stephen A (2022. ) Characterization and first-in-human clinical dose-escalation safety evaluation of a next-gen human freeze-dried plasma.Transfusion, , 62 (2 ) ,406-417 More Information

Rubinstein, Jeremy D; Jodele, Sonata; Heyenbruch, Daria; Wilhelm, Jamie; Thomas, Shawn; Lutzko, Carolyn; Zhu, Xiang; Leemhuis, Thomas; Cancelas, Jose A; Keller, Michael; Bollard, Catherine M; Hanley, Patrick J; Boghdadly, Zeinab El; Mims, Alice; Davies, Stella M; Grimley, Michael S; Nelson, Adam S (2022. ) Off-the-Shelf Third-Party Virus-Specific T Cell Therapy to Treat JC Polyomavirus Infection in Hematopoietic Stem Cell Transplantation Recipients.Transplantation and cellular therapy, , 28 (2 ) ,116.e1-116.e7 More Information

Noel, John G; Ramser, Seth W; Pitstick, Lori; Bonamer, John P; Mackenzie, Bryan; Seu, Katie G; Kalfa, Theodosia A; Cancelas, Jose A; Gardner, Jason C (2022. ) M-CSF supports medullary erythropoiesis and erythroid iron demand following burn injury through its activity on homeostatic iron recycling.Scientific reports, , 12 (1 ) ,1235 More Information

Rubinstein, Jeremy D; Zhu, Xiang; Leemhuis, Thomas; Pham, Giang; Ray, Lorraine; Emberesh, Sana; Jodele, Sonata; Thomas, Shawn; Cancelas, Jose A; Bollard, Catherine M; Hanley, Patrick J; Keller, Michael D; Grimley, Olivia; Clark, Diana; Clark, Teri; Lindestam Arlehamn, Cecilia S; Sette, Alessandro; Davies, Stella M; Nelson, Adam S; Grimley, Michael S; Lutzko, Carolyn (2021. ) Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted.Blood advances, , 5 (17 ) ,3309-3321 More Information

Singh, Abhishek K; Cancelas, Jose A (2021. ) Mitochondria Transfer in Bone Marrow Hematopoietic Activity.Current stem cell reports, , 7 (1 ) ,1-12 More Information

Mock D.M.; Stowell S.R.; Franco R.S.; Kyosseva S.V.; Nalbant D.; Schmidt R.L.; Cress G.A.; Strauss R.G.; Cancelas J.A.; von Goetz M.; North A.K.; Widness J.A. (04-01-2022. ) Antibodies against biotin-labeled red blood cells can shorten posttransfusion survival.Transfusion, , 62 (4 ) ,770-782 More Information

Vandenbroeke T, Gloor C, Wingfield T, Leite C, Carr K, Turner C, Ngamsuntikul S, Sutor L, Compton F, Nestheide S, Rugg N, Cancelas JA, Dumont LJ (2024. ) In vitro quality parameters of whole blood-derived platelets pooled using two different platelet pooling sets and stored up to 7 days are similar.Transfusion, , 54 (1 ) ,132-140. More Information

Singh AK, Prasad P, Cancelas JA (2023. ) Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis.Front Cell Dev Biol, , 11 ,art. no. 1325291. More Information

Thant M, Cancelas J, Kaplan A (2023. ) The enhanced direct antiglobulin test in current practice has a limited impact on management of adult patients.Transfus Apher Sci, , 62 (5 ) ,103768 More Information

Dandamudi A, Huzoor A, Cancelas J, Zheng Y (2023. ) Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies.Int J Mol Sci, , 24 (3 ) ,4167 More Information

Yazer, Mark H; Spinella, Philip C; Doyle, Leilani; Kaufman, Richard M; Dunn, Robyn; Hess, John R; Filho, Luiz Amorim; Fontaine, Magali; Gathof, Birgit; Jackson, Bryon; Murphy, Michael F; Pasion, Jeremiah; Raval, Jay S; Rosinski, Kristin; Seheult, Jansen; Shih, Andrew W; Sperry, Jason; Staves, Julie; Tuott, Erin E; Ziman, Alyssa; Triulzi, Darrell J (2020. ) Transfusion of Uncrossmatched Group O Erythrocyte-containing Products Does Not Interfere with Most ABO Typings.Anesthesiology, , 132 (3 ) ,525-534 More Information

Atreya, Chintamani; Glynn, Simone; Busch, Michael; Kleinman, Steve; Snyder, Edward; Rutter, Sara; AuBuchon, James; Flegel, Willy; Reeve, David; Devine, Dana; Cohn, Claudia; Custer, Brian; Goodrich, Raymond; Benjamin, Richard J; Razatos, Anna; Cancelas, Jose; Wagner, Stephen; Maclean, Michelle; Gelderman, Monique; Cap, Andrew; Ness, Paul (2019. ) Proceedings of the Food and Drug Administration public workshop on pathogen reduction technologies for blood safety 2018 (Commentary, p. 3026).Transfusion, , 59 (9 ) ,3002-3025 More Information

Liu, Shutong; de Castro, Luis F; Jin, Ping; Civini, Sara; Ren, Jiaqiang; Reems, Jo-Anna; Cancelas, Jose; Nayak, Ramesh; Shaw, Georgina; O'Brien, Timothy; McKenna, David H; Armant, Myriam; Silberstein, Leslie; Gee, Adrian P; Hei, Derek J; Hematti, Peiman; Kuznetsov, Sergei A; Robey, Pamela G; Stroncek, David F (2017. ) Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers.Scientific reports, , 7 ,46731 More Information

Spitalnik, Steven L; Triulzi, Darrell; Devine, Dana V; Dzik, Walter H; Eder, Anne F; Gernsheimer, Terry; Josephson, Cassandra D; Kor, Daryl J; Luban, Naomi L C; Roubinian, Nareg H; Mondoro, Traci; Welniak, Lisbeth A; Zou, Shimian; Glynn, Simone (2015. ) 2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium.Transfusion, , 55 (9 ) ,2282-90 More Information

Estcourt, Lise J; Heddle, Nancy; Kaufman, Richard; McCullough, Jeffrey; Murphy, Michael F; Slichter, Sherrill; Wood, Erica M; Stanworth, Simon J (2013. ) The challenges of measuring bleeding outcomes in clinical trials of platelet transfusions.Transfusion, , 53 (7 ) ,1531-43 More Information

Bandarenko, Nicholas; Cancelas, Jose; Snyder, Edward L; Hay, Shauna N; Rugg, Neeta; Corda, Tammy; Joines, Amy D; Gormas, Jennifer F; Pratt, Gayle P; Kowalsky, Richard; Rose, Michael; Rose, Leslie; Foley, Jim; Popovsky, Mark A (2007. ) Successful in vivo recovery and extended storage of additive solution (AS)-5 red blood cells after deglycerolization and resuspension in AS-3 for 15 days with an automated closed system.Transfusion, , 47 (4 ) ,680-6 More Information

Nassar, Nicolas; Cancelas, Jose; Zheng, Jie; Williams, David A; Zheng, Yi (2006. ) Structure-function based design of small molecule inhibitors targeting Rho family GTPases.Current topics in medicinal chemistry, , 6 (11 ) ,1109-16 More Information

Singh AK, Prasad P, Cancelas JA (2023. ) Mesenchymal stromal cells, metabolism, and mitochondrial transfer in bone marrow normal and malignant hematopoiesis .Front Cell Dev Biol, , 1325291

Akbar, Huzoor; Cancelas, Jose; Williams, David A; Zheng, Jie; Zheng, Yi (2006. ) Rational design and applications of a Rac GTPase-specific small molecule inhibitor.Methods in enzymology, , 406 ,554-65 More Information

NCBI Bibleography Link:  http://www.ncbi.nlm.nih.gov/sites/myncbi/jose.cancelas.1/bibliography/41148934/public/?sort=date&direction=descending,

Research - Hoxworth Blood Center, Univ. Cincinnati
3130 Highland Ave Rm 4059
Cincinnati  Ohio, 45267-0055
Phone: 5135581324
jose.cancelas@uc.edu