Alex Chang

Alex L Chang , MD

Assistant Professor of Clinical

MSB 1461
231 Albert Sabin Way
Cincinnati, Ohio 45267-0558
Phone 513-558-4785
Email changax@ucmail.uc.edu

Education

Bachelor's Degree: University of Texas 2008 (Biomedical Engineering)

Medical Degree: Baylor College of Medicine 2012

Fellowship : University of Cincinnati Cincinnati, OH, 2016

Certifications

American Board of Surgery (Certification Date: 10-20-2020 )

Clinical Interests

General Surgery

Transplant Surgery

Abdominal Hernia

Acute Kidney Injury (AKI)

Acute Renal failure (Acute kidney failure)

Biliary Tract Liver Disease

Cholangitis

Cirrhosis

Groin Hernias

Hepatobiliary

Kidney Disease

Liver disease

Liver Failure

Nonalcoholic Fatty Liver Disease (NAFLD)

Nonalcoholic Steatohepatitis (NASH)

Obstructive Biliary Tract Liver Disease

Renal Artery Obstruction

Renal Artery Stenosis

Renal Cancer

Renal Cell Carcinoma

Specialities

Surgery-Transplant

Publications

Peer Reviewed Publications

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2016. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, , More Information

Ertel, Audrey E; Wima, Koffi; Chang, Alex L; Hoehn, Richard S; Hohmann, Samual F; Edwards, Michael J; Abbott, Daniel E; Shah, Shimul A (2016. ) Risk of Reoperation Within 90 Days of Liver Transplantation: A Necessary Evil?.Journal of the American College of Surgeons, , More Information

Hoehn, Richard S; Jernigan, Peter L; Chang, Alex L; Edwards, Michael J; Pritts, Timothy A (2015. ) Molecular mechanisms of erythrocyte aging.Biological chemistry, , 396 (6-7 ) ,621-31 More Information

Fan, Yihui; Yu, Yang; Shi, Yi; Sun, Wenjing; Xie, Min; Ge, Ningling; Mao, Renfang; Chang, Alex; Xu, Gufeng; Schneider, Michael D; Zhang, Hong; Fu, Songbin; Qin, Jun; Yang, Jianhua (2010. ) Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation.The Journal of biological chemistry, , 285 (8 ) ,5347-60 More Information

Chang, Alex L; Hoehn, Richard S; Jernigan, Peter; Cox, Daniel; Schreiber, Martin; Pritts, Timothy A (2016. ) Previous Cryopreservation Alters the Natural History of the Red Blood Cell Storage Lesion.Shock (Augusta, Ga.), , More Information

Abbott, Daniel E; Sutton, Jeffrey M; Jernigan, Peter L; Chang, Alex; Frye, Patrick; Shah, Shimul A; Schauer, Daniel P; Eckman, Mark H; Ahmad, Syed A; Sussman, Jeffrey J (2016. ) Prophylactic pasireotide administration following pancreatic resection reduces cost while improving outcomes.Journal of surgical oncology, , 113 (7 ) ,784-8 More Information

Hoehn, Richard S; Jernigan, Peter L; Chang, Alex L; Edwards, Michael J; Caldwell, Charles C; Gulbins, Erich; Pritts, Timothy A (2016. ) Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 39 (1 ) ,331-40 More Information

Chang, Alex L; Pritts, Timothy A (2017. ) Reply to "Packed Red Blood Cells Accumulate Oxidative Stress With Increased Storage Duration".Shock (Augusta, Ga.), , 48 (2 ) ,271 More Information

Chang, Alex; Kim, Young; Hoehn, Richard; Jernigan, Peter; Pritts, Timothy (2017. ) Cryopreserved packed red blood cells in surgical patients: past, present, and future.Blood transfusion = Trasfusione del sangue, , 15 (4 ) ,341-347 More Information

Chang, Alex L; Kim, Young; Seitz, Aaron P; Schuster, Rebecca M; Pritts, Timothy A (2017. ) pH modulation ameliorates the red blood cell storage lesion in a murine model of transfusion.The Journal of surgical research, , 212 ,54-59 More Information

Chang, Alex L; Kim, Young; Seitz, Aaron P; Schuster, Rebecca M; Lentsch, Alex B; Pritts, Timothy A (2017. ) Erythrocyte-Derived Microparticles Activate Pulmonary Endothelial Cells in a Murine Model of Transfusion.Shock (Augusta, Ga.), , 47 (5 ) ,632-637 More Information

Chang, Alex L; Kim, Young; Ertel, Audrey E; Hoehn, Richard S; Wima, Koffi; Abbott, Daniel E; Shah, Shimul A (2017. ) Case mix-adjusted cost of colectomy at low-, middle-, and high-volume academic centers.Surgery, , 161 (5 ) ,1405-1413 More Information

Hoehn, Richard S; Jernigan, Peter L; Japtok, Lukasz; Chang, Alex L; Midura, Emily F; Caldwell, Charles C; Kleuser, Burkhard; Lentsch, Alex B; Edwards, Michael J; Gulbins, Erich; Pritts, Timothy A (2017. ) Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.Annals of surgery, , 265 (1 ) ,218-226 More Information

Hoehn, Richard S; Hanseman, Dennis J; Chang, Alex L; Daly, Megan C; Ertel, Audrey E; Abbott, Daniel E; Shah, Shimul A; Paquette, Ian M (2017. ) Surgeon Characteristics Supersede Hospital Characteristics in Mortality After Urgent Colectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, , 21 (1 ) ,23-32 More Information

Abbott, Daniel E; Sutton, Jeffrey M; Jernigan, Peter L; Chang, Alex; Frye, Patrick; Shah, Shimul A; Schauer, Daniel P; Eckman, Mark H; Ahmad, Syed A; Sussman, Jeffrey J (2016. ) How Much Should We Pay to Minimize Pancreatic Leak? The Cost-effectiveness of Pasireotide in Pancreatic Resection: RETRACTED.Annals of surgery, , More Information

Ertel, Audrey E; Wima, Koffi; Hoehn, Richard S; Chang, Alex L; Hohmann, Samuel F; Ahmad, Syed A; Sussman, Jeffrey J; Shah, Shimul A; Abbott, Daniel E (2016. ) Variability in postoperative resource utilization after pancreaticoduodenectomy: Who is responsible.Surgery, , 160 (6 ) ,1477-1484 More Information

Kim, Young; Chang, Alex L; Wima, Koffi; Ertel, Audrey E; Diwan, Tayyab S; Abbott, Daniel E; Shah, Shimul A (2016. ) The impact of morbid obesity on resource utilization after renal transplantation.Surgery, , 160 (6 ) ,1544-1550 More Information

Go, Derek E; Abbott, Daniel E; Wima, Koffi; Hanseman, Dennis J; Ertel, Audrey E; Chang, Alex L; Shah, Shimul A; Hoehn, Richard S (2016. ) Addressing the High Costs of Pancreaticoduodenectomy at Safety-Net Hospitals.JAMA surgery, , 151 (10 ) ,908-914 More Information

Chang, Alex L; Cortez, Alexander R; Bondoc, Alexander; Schauer, Daniel P; Fitch, Angela; Shah, Shimul A; Woodle, Steve E; Diwan, Tayyab (2016. ) Metabolic syndrome in liver transplantation: A preoperative and postoperative concern.Surgery, , 160 (4 ) ,1111-1117 More Information

Ertel, Audrey E; Chang, Alex L; Kim, Young; Shah, Shimul A (2016. ) Management of gastrointestinal bleeding in patients with cirrhosis.Current problems in surgery, , 53 (8 ) ,366-95 More Information

Hoehn, Richard S; Hanseman, Dennis J; Go, Derek; Wima, Koffi; Chang, Alex; Ertel, Audrey E; Shah, Shimul A; Abbott, Daniel E (2016. ) Hospital resources are associated with value-based surgical performance.The Journal of surgical research, , 204 (1 ) ,15-21 More Information

Kim, Young; Xia, Brent T; Chang, Alex L; Pritts, Timothy A (2016. ) Role of Leukoreduction of Packed Red Blood Cell Units in Trauma Patients: A Review.International journal of hematology research, , 2 (2 ) ,124-129 More Information

Kim, Young; Xia, Brent T; Jung, Andrew D; Chang, Alex L; Abplanalp, William A; Caldwell, Charles C; Goodman, Michael D; Pritts, Timothy A (2018. ) Microparticles from stored red blood cells promote a hypercoagulable state in a murine model of transfusion.Surgery, , 163 (2 ) ,423-429 More Information

Chang, Alex; Abbott, Daniel E Cost-Effectiveness Analysis in Cancer Care. Cancer treatment and research, , 168 ,377-91

Invited Publications

Ertel A, Chang A, Kim Y, Shah SA (2016. ) Management of Gastrointestinal Bleeding in Patients with Cirrhosis .Curr Probl Surg, 53 (8 ) ,366-95

Other Publications

Chang, Alex L., Abt, Peter L., Atluri, Pavan, Fuller, Stephanie (2021. ) Combined Sequential Heart-Liver Transplantation .Operative Techniques in Thoracic and Cardiovascular Surgery, 26 (1 ) ,99 -111 Elsevier

Book Chapter

Chang A, Abbott D (2016 ) Cost effectiveness analysis in cancer care Cancer Treatment and Research Series: Gastrointestinal Malignancies .Springer

Chang A, Abbott D (2017 ) Chronic pancreatitis: Puestow and Frey procedures Case Based Lessons in the Management of Complex Hepato-Pancreato-Biliary Surgery .Springer

Chang A (2017 ) Benign liver disease, cirrhosis, and portal hypertension The Mont Reid Surgical Handbook, 7th ed .Elsevier

Chang A (2017 ) Liver tumors The Mont Reid Surgical Handbook, 7th ed .Elsevier

Chang, A, Shah, S (2019 ) Management of Portal Hypertension Shackelford's Surgery of the Alimentary Tract .(pp. 1575 -1590).Elsevier (Author)

Presentations

Poster Presentations

Chang, Alex, Cederquist, Kelly, Abt, Peter, Wang, Grace, Jackson, Benjamin, Naji, Ali (06-06-2021. ) (In Press. ) Single center experience in ex vivo hilar renal artery aneurysm repair and autotransplantation .American Transplant Congress, Virtual. . Professional Meeting. . Level:National

Paper Presentations

Tapia N, Chang AL, Norman M, et al (2012. ) Hyperfibrinolysis on thromboelastogram (TEG) predicts mortality in massively transfused trauma patients .American College of Surgeons Surgical Forum, Chicago, IL.

Tapia N, Chang AL, Norman M, et al (2012. ) Thromboelastogram (TEG) guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients .American Association for the Surgery of Trauma, Kauai, HI.

Chang, A, Shah, S (2016. ) A Predictive Model to Reduce Hospital Cost after Coronary Artery Bypass Grafting .Ohio Chapter ACS Annual Meeting, Columbus, OH.

Chang A, Cortez A, Bondoc A, et al (2016. ) Metabolic Syndrome in Liver Transplantation: a Preoperative and Post Operative Concern .Central Surgical Association, Montreal, Quebec.

Chang A, Kim Y, Seitz A, Pritts T (2016. ) Microparticles From Stored Red Blood Cells Activate Lung Endothelial Cells .American College of Surgery Committee on Trauma Annual Meeting, San Diego, CA.

Chang A, Ertel A, Hoehn R, et al (2016. ) Case-mix Adjusted Cost Variation by Academic Hospital Volume After Surgery .American Surgical Congress, Jacksonville, FL.

Chang A, Wima K, Shah S (2016. ) The Impact of Morbid Obesity on Kidney Transplant Cost and Resource Utilization .American Surgical Congress, Jacksonville, FL.

Chang A, Hoehn R, Jernigan P, et al (2016. ) pH Dependent Modulation of the Red Blood Cell Storage Lesion .Eastern Association for the Surgery of Trauma, San Antonio, TX.

Chang A, Young K, Seitz A, et al (2015. ) Red Blood Cell Derived Microparticles Activate Microvascular Inflammatory Cascades in a Murine Model of Transfusion .ACS Ohio Committee on Trauma, Cleveland, OH.

Chang A, Hoehn R, Jernigan P, Pritts T (2015. ) Previous Cryopreservation Alters the Red Blood Cell Storage Lesion and Glutathione Equilibrium .American College of Surgeons Clinical Congress, Chicago, IL.

Chang A, Hoehn R, Jernigan P, et al (2015. ) Previous Cryopreservation Accelerates Subsequent Liquid-Phase Development of the Red Blood Cell Storage Lesion .Military Health System Research Symposium, Fort Lauderdale, FL.

Chang A, Hoehn R, Jernigan P, et al (2015. ) Previous Cryopreservation Accelerates Subsequent Liquid-Phase Development of the Red Blood Cell Storage Lesion .38th Annual Conference on Shock, Denver, CO.

Chang A, Slater JH, Gaubert HE, et al (2007. ) Cell Motility Depends on the Clustering of Ligands Not on the Average Density of Ligands .Biomedical Engineering Society Annual Fall Meeting. Los Angeles, CA.

Chang, Alex, Chen, Melissa, Abt, Peter, Bittermann, Therese (06-06-2021. ) Machine perfusion of kidney grafts in simultaneous liver kidney transplantation: national trends and outcomes .virtual. Professional Meeting. Level:National

Honors and Awards

2016 Winner of the 2015 Ohio ACS Committee on Trauma Basic Science Resident Research Competition; First Place in Region V and a National Finalist

2016 Winner of 2016 Shock Society Travel Award

2016 Finalist, Basic Science Section, Department of Surgery Resident Research Award

Service

University of Cincinnati General Surgery Residency Class of 2019 Class Representative 2017-2018

University Hospital Resident Patient Safety Council, 2014-2015

University of Cincinnati College of Medicine Surgery Interest Group Resident Mentor 2015-2016

Contact Information

Academic - MSB 1461
231 Albert Sabin Way
Cincinnati  Ohio, 45267-0558
Phone: 513-558-4785
changax@ucmail.uc.edu