Ameet A Chimote

Master's Degree: Nagpur University Sewagram, India, 1998

Master's Degree: Wright State University Dayton, Ohio, 2003 (Biomedical Engineering)

Doctoral Degree: Wright State University Dayton, OH, 2009 (Biomedical Sciences )

Postdoctoral Fellowship: Univsrsity of Cincinnati Cincinnati, OH , 2015 (Nephrology)

Peer Reviewed Publications

Chimote, Ameet A; Balajthy, Andras; Arnold, Michael J; Newton, Hannah S; Hajdu, Peter; Qualtieri, Julianne; Wise-Draper, Trisha; Conforti, Laura  (2018). A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. Science signaling, 11 (527) More Information

Chimote, Ameet A; Hajdu, Peter; Sfyris, Alexandros M; Gleich, Brittany N; Wise-Draper, Trisha; Casper, Keith A; Conforti, Laura  (2017). Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. Cancer research, 77 (1) , 53-61More Information

Chimote, Ameet A; Hajdu, Peter; Kottyan, Leah C; Harley, John B; Yun, Yeoheung; Conforti, Laura  (2016). Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype. Journal of autoimmunity, 69, 86-93More Information

Hajdu, Peter; Martin, Geoffrey V; Chimote, Ameet A; Szilagyi, Orsolya; Takimoto, Koichi; Conforti, Laura  (2015). The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. Molecular biology of the cell, 26 (9) , 1640-51More Information

Chimote, Ameet A; Hajdu, Peter; Kucher, Vladimir; Boiko, Nina; Kuras, Zerrin; Szilagyi, Orsolya; Yun, Yeo-Heung; Conforti, Laura  (2013). Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells. Journal of immunology (Baltimore, Md. : 1950), 191 (12) , 6273-80More Information

Hajdu, Péter; Chimote, Ameet A; Thompson, Tyler H; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura  (2013). Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity. Biomaterials, 34 (38) , 10249-57More Information

Kuras, Zerrin; Kucher, Vladimir; Gordon, Scott M; Neumeier, Lisa; Chimote, Ameet A; Filipovich, Alexandra H; Conforti, Laura  (2012). Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex. American journal of physiology. Cell physiology, 302 (10) , C1504-12More Information

Chimote, Ameet A; Kuras, Zerrin; Conforti, Laura  (2012). Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes. The Journal of biological chemistry, 287 (3) , 2055-67More Information

Kuras, Zerrin; Yun, Yeo-Heung; Chimote, Ameet A; Neumeier, Lisa; Conforti, Laura  (2012). KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells. PloS one, 7 (8) , e43859More Information

Chimote, Ameet A; Adragna, Norma C; Lauf, Peter K  (2010). Ion transport in a human lens epithelial cell line exposed to hyposmotic and apoptotic stress. Journal of cellular physiology, 223 (1) , 110-22More Information

Lauf, Peter K; Misri, Sandeep; Chimote, Ameet A; Adragna, Norma C  (2008). Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells. American journal of physiology. Cell physiology, 294 (3) , C820-32More Information

Lauf, Peter K; Chimote, Ameet A; Adragna, Norma C  (2008). Lithium fluxes indicate presence of Na-Cl cotransport (NCC) in human lens epithelial cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 21 (5-6) , 335-46More Information

Misri, Sandeep; Chimote, Ameet A; Adragna, Norma C; Warwar, Ronald; Brown, Thomas L; Lauf, Peter K  (2006). KCC isoforms in a human lens epithelial cell line (B3) and lens tissue extracts. Experimental eye research, 83 (5) , 1287-94More Information

Khodoun, Marat; Chimote, Ameet A; Ilyas, Farhan Z; Duncan, Heather J; Moncrieffe, Halima; Kant, K Shashi; Conforti, Laura  (2020). Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. Science advances, 6 (47) More Information

Newton, Hannah S; Gawali, Vaibhavkumar S; Chimote, Ameet A; Lehn, Maria A; Palackdharry, Sarah M; Hinrichs, Benjamin H; Jandarov, Roman; Hildeman, David; Janssen, Edith M; Wise-Draper, Trisha M; Conforti, Laura  (2020). PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. Journal for immunotherapy of cancer, 8 (2) More Information

Chimote, Ameet A; Gawali, Vaibhavkumar S; Newton, Hannah S; Wise-Draper, Trisha M; Conforti, Laura  (2020). A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer. Frontiers in pharmacology, 11, 143More Information

Chirra, Martina; Newton, Hannah S; Gawali, Vaibhavkumar S; Wise-Draper, Trisha M; Chimote, Ameet A; Conforti, Laura  (2022). How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity. Cancers, 14 (15) More Information

Gawali, Vaibhavkumar S; Chimote, Ameet A; Newton, Hannah S; Feria-Garzón, Manuel G; Chirra, Martina; Janssen, Edith M; Wise-Draper, Trisha M; Conforti, Laura  (2021). Immune Checkpoint Inhibitors Regulate K+ Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients. Frontiers in pharmacology, 12, 742862More Information

Newton, Hannah S; Chimote, Ameet A; Arnold, Michael J; Wise-Draper, Trisha M; Conforti, Laura  (2021). Targeted knockdown of the adenosine A2A receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells. Molecular therapy. Methods & clinical development, 21, 133-143More Information

Academic - CARE/Crawley
Room 6884
Cincinnati  Ohio, 45267
Phone: 513-558-6922
Fax: 513-558-4309
ameet.chimote@uc.edu