Ameet Chimote

Ameet A Chimote

Research Scientist



COM IM NEP Conforti Lab - 0585

Room 6884
Cincinnati, Ohio 45267


Peer Reviewed Publications

Chimote, Ameet A; Balajthy, Andras; Arnold, Michael J; Newton, Hannah S; Hajdu, Peter; Qualtieri, Julianne; Wise-Draper, Trisha; Conforti, Laura (2018. ) A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment.Science signaling, , 11 (527 ) ,

Chimote, Ameet A; Hajdu, Peter; Sfyris, Alexandros M; Gleich, Brittany N; Wise-Draper, Trisha; Casper, Keith A; Conforti, Laura (2017. ) Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer.Cancer research, , 77 (1 ) ,53-61

Chimote, Ameet A; Hajdu, Peter; Kottyan, Leah C; Harley, John B; Yun, Yeoheung; Conforti, Laura (2016. ) Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype.Journal of autoimmunity, , 69 ,86-93

Hajdu, Peter; Martin, Geoffrey V; Chimote, Ameet A; Szilagyi, Orsolya; Takimoto, Koichi; Conforti, Laura (2015. ) The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin.Molecular biology of the cell, , 26 (9 ) ,1640-51

Chimote, Ameet A; Hajdu, Peter; Kucher, Vladimir; Boiko, Nina; Kuras, Zerrin; Szilagyi, Orsolya; Yun, Yeo-Heung; Conforti, Laura (2013. ) Selective inhibition of KCa3.1 channels mediates adenosine regulation of the motility of human T cells.Journal of immunology (Baltimore, Md. : 1950), , 191 (12 ) ,6273-80

Hajdu, Péter; Chimote, Ameet A; Thompson, Tyler H; Koo, Youngmi; Yun, Yeoheung; Conforti, Laura (2013. ) Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity.Biomaterials, , 34 (38 ) ,10249-57

Kuras, Zerrin; Kucher, Vladimir; Gordon, Scott M; Neumeier, Lisa; Chimote, Ameet A; Filipovich, Alexandra H; Conforti, Laura (2012. ) Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.American journal of physiology. Cell physiology, , 302 (10 ) ,C1504-12

Chimote, Ameet A; Kuras, Zerrin; Conforti, Laura (2012. ) Disruption of kv1.3 channel forward vesicular trafficking by hypoxia in human T lymphocytes.The Journal of biological chemistry, , 287 (3 ) ,2055-67

Kuras, Zerrin; Yun, Yeo-Heung; Chimote, Ameet A; Neumeier, Lisa; Conforti, Laura (2012. ) KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells.PloS one, , 7 (8 ) ,e43859

Chimote, Ameet A; Adragna, Norma C; Lauf, Peter K (2010. ) Ion transport in a human lens epithelial cell line exposed to hyposmotic and apoptotic stress.Journal of cellular physiology, , 223 (1 ) ,110-22

Lauf, Peter K; Misri, Sandeep; Chimote, Ameet A; Adragna, Norma C (2008. ) Apparent intermediate K conductance channel hyposmotic activation in human lens epithelial cells.American journal of physiology. Cell physiology, , 294 (3 ) ,C820-32

Lauf, Peter K; Chimote, Ameet A; Adragna, Norma C (2008. ) Lithium fluxes indicate presence of Na-Cl cotransport (NCC) in human lens epithelial cells.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, , 21 (5-6 ) ,335-46

Misri, Sandeep; Chimote, Ameet A; Adragna, Norma C; Warwar, Ronald; Brown, Thomas L; Lauf, Peter K (2006. ) KCC isoforms in a human lens epithelial cell line (B3) and lens tissue extracts.Experimental eye research, , 83 (5 ) ,1287-94

Khodoun, Marat; Chimote, Ameet A; Ilyas, Farhan Z; Duncan, Heather J; Moncrieffe, Halima; Kant, K Shashi; Conforti, Laura (2020. ) Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus.Science advances, , 6 (47 ) ,

Newton, Hannah S; Gawali, Vaibhavkumar S; Chimote, Ameet A; Lehn, Maria A; Palackdharry, Sarah M; Hinrichs, Benjamin H; Jandarov, Roman; Hildeman, David; Janssen, Edith M; Wise-Draper, Trisha M; Conforti, Laura (2020. ) PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer.Journal for immunotherapy of cancer, , 8 (2 ) ,

Chimote, Ameet A; Gawali, Vaibhavkumar S; Newton, Hannah S; Wise-Draper, Trisha M; Conforti, Laura (2020. ) A Compartmentalized Reduction in Membrane-Proximal Calmodulin Reduces the Immune Surveillance Capabilities of CD8+ T Cells in Head and Neck Cancer.Frontiers in pharmacology, , 11 ,143

Post Graduate Training and Education

1993-1998 MBBS, Nagpur University , Mahatma Gandhi Institute of Medical Sciences , , Sewagram, India

2001-2003 M.S. Biomedical Engineering, Wright State University, , Dayton OH

2003-2009 Ph.D. Biomedical Sciences , Wright State University, , Dayton OH

2010-2015 Postdoctoral Fellow, Internal Medicine- Nephrology Mentor: Dr. Laura Conforti, University of Cincinnati, , Cincinnati OH

Contact Information

Academic - CARE/Crawley
Room 6884
Cincinnati  Ohio, 45267
Phone: 513-558-6922
Fax: 513-558-4309