Edmund M Choi, PhD

B.A.: University of California, Berkeley 1975 (Bacteriology)

Ph.D.: University of California, Los Angeles 1981 (Microbiology and Immunology)

Post Doc: Harvard School of Medicine 1985 (Genetics)

Immunology, Microbiology

1986 -1993 Assistant Professor, Microbiology and Molecular Genetics until 1989 Molecular Genetics, Biochemistry and Microbiology 1989-present, University of Cincinnati College of Medicine, Cincinnati, OH

1993 -To Present Associate Professor, Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH

Grant: #5-P60-AR-44059-05-A0-S0-E0 Investigators:Choi, Edmund 06-01-1996 -05-31-2001 National Institute of Arthritis, Musculoskeletal and Skin Disease Molecular Genotyping and Sequencing Core Role:PI $66,473.00 Closed Level:Federal

Peer Reviewed Publications

Blanco, L; Choi, E M; Connolly, K; Thompson, M R; Bonventre, P F  (1990). Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. Infection and immunity, 58 (9) , 3020-8

Welch, T R; Beischel, L S; Choi, E M  (1989). Molecular genetics of C4B deficiency in IgA nephropathy. Human immunology, 26 (4) , 353-63

Griffith, I J; Choi, E M; Glimcher, L H  (1987). A single base mutation in an I-A alpha-chain gene alters T-cell recognition. Proceedings of the National Academy of Sciences of the United States of America, 84 (4) , 1090-3

Benedict, W F; Baker, M S; Haroun, L; Choi, E; Ames, B N  (1977). Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. Cancer research, 37 (7 Pt 1) , 2209-13

McCann, J; Choi, E; Yamasaki, E; Ames, B N  (1975). Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proceedings of the National Academy of Sciences of the United States of America, 72 (12) , 5135-9

Rogers, J; Choi, E; Souza, L; Carter, C; Word, C; Kuehl, M; Eisenberg, D; Wall, R  (1981). Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains. Cell, 26 (1 Pt 1) , 19-27

Choi, E; Kuehl, M; Wall, R  (1980). RNA splicing generates a variant light chain from an aberrantly rearranged kappa gene. Nature, 286 (5775) , 776-9

Cohn, L E; Glimcher, L H; Waldmann, R A; Smith, J A; Ben-Nun, A; Seidman, J G; Choi, E  (1986). Identification of functional regions on the I-Ab molecule by site-directed mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, 83 (3) , 747-51

Glimcher, L H; McKean, D J; Choi, E; Seidman, J G  (1985). Complex regulation of class II gene expression: analysis with class II mutant cell lines. Journal of immunology (Baltimore, Md. : 1950), 135 (5) , 3542-50

Ben-Nun, A; Choi, E; McIntyre, K R; Leeman, S A; McKean, D J; Seidman, J G; Glimcher, L H  (1985). DNA-mediated transfer of major histocompatibility class II I-Ab and I-Abm12 genes into B lymphoma cells: molecular and functional analysis of introduced antigens. Journal of immunology (Baltimore, Md. : 1950), 135 (2) , 1456-64

Gasser, D L; Klein, K A; Choi, E; Seidman, J G  (1985). A new beta-2 microglobulin allele in mice defined by DNA sequencing. Immunogenetics, 22 (4) , 413-6

Seidman, C E; Duby, A D; Choi, E; Graham, R M; Haber, E; Homcy, C; Smith, J A; Seidman, J G  (1984). The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science (New York, N.Y.), 225 (4659) , 324-6

Murre, C; Choi, E; Weis, J; Seidman, J G; Ozato, K; Liu, L; Burakoff, S J; Reiss, C S  (1984). Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains. The Journal of experimental medicine, 160 (1) , 167-78

Choi, E; McIntyre, K; Germain, R N; Seidman, J G  (1983). Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. Science (New York, N.Y.), 221 (4607) , 283-6

Brzezinski, J L; Deka, R; Menon, A G; Glass, D N; Choi, E  (2005). Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations. International journal of immunogenetics, 32 (6) , 413-20More Information

Brzezinski, J L; Glass, D N; Choi, E  (2001). A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes. Genes and immunity, 2 (5) , 290-1More Information

Cullen, C M; Jameson, S C; DeLay, M; Cottrell, C; Becken, E T; Choi, E; Hirsch, R  (1999). A divalent major histocompatibility complex/IgG1 fusion protein induces antigen-specific T cell activation in vitro and in vivo. Cellular immunology, 192 (1) , 54-62More Information

Thompson, S D; Murray, K J; Grom, A A; Passo, M H; Choi, E; Glass, D N  (1998). Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: evidence for antigenic selection of T cells in the synovium. Arthritis and rheumatism, 41 (3) , 482-97More Information

Grom, A A; von Knorre, C; Murray, K J; Donnelly, P A; Glass, D N; Choi, E  (1996). T-cell receptor BV6S1 null alleles and HLA-DR1 haplotypes in polyarticular outcome juvenile rheumatoid arthritis. Human immunology, 45 (2) , 152-6

Lambert, L E; Berling, J S; Thompson, S D; Harton, J A; Bishop, G A; Choi, E  (1995). Polymorphism in the beta chain of IAq versus IAp influences presentation of protein but not peptide antigens. Cellular immunology, 165 (2) , 202-10More Information

Thompson, S D; Grom, A A; Bailey, S; Luyrink, L; Giannini, E H; Murray, K; Passo, M H; Lovell, D J; Choi, E; Glass, D N  (1995). Patterns of T lymphocyte clonal expansion in HLA-typed patients with juvenile rheumatoid arthritis. The Journal of rheumatology, 22 (7) , 1356-64

Cullen, C M; Blanco, L R; Bonventre, P F; Choi, E  (1995). A toxic shock syndrome toxin 1 mutant that defines a functional site critical for T-cell activation. Infection and immunity, 63 (6) , 2141-6

De Inocencio, J; Choi, E; Glass, D N; Hirsch, R  (1995). T cell receptor repertoire differences between African Americans and Caucasians associated with polymorphism of the TCRBV3S1 (V beta 3.1) gene. Journal of immunology (Baltimore, Md. : 1950), 154 (9) , 4836-41

Grom, A A; Thompson, S D; Luyrink, L; Passo, M; Choi, E; Glass, D N  (1993). Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, 90 (23) , 11104-8

Luyrink, L; Gabriel, C A; Thompson, S D; Grom, A A; Maksymowych, W P; Choi, E; Glass, D N  (1993). Reduced expression of a human V beta 6.1 T-cell receptor allele. Proceedings of the National Academy of Sciences of the United States of America, 90 (10) , 4369-73

Maksymowych, W P; Gabriel, C A; Luyrink, L; Melin-Aldana, H; Elma, M; Giannini, E H; Lovell, D J; Van Kerckhove, C; Leiden, J; Choi, E  (1992). Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset. Immunogenetics, 35 (4) , 257-62

van Kerckhove, C; Luyrink, L; Taylor, J; Melin-Aldana, H; Balakrishnan, K; Maksymowych, W; Elma, M; Lovell, D; Choi, E; Glass, D N  (1991). HLA-DQA1*0101 haplotypes and disease outcome in early onset pauciarticular juvenile rheumatoid arthritis. The Journal of rheumatology, 18 (6) , 874-9

Maksymowych, W P; Gabriel, C A; Luyrink, L; Van Kerckhove, C; Leiden, J; Choi, E; Glass, D N  (1991). Polymorphic markers related to a single Tcrb-V6 gene segment. Immunogenetics, 33 (4) , 281-5

Welch, T R; Beischel, L S; Choi, E; Balakrishnan, K; Bishof, N A  (1990). Uniparental isodisomy 6 associated with deficiency of the fourth component of complement. The Journal of clinical investigation, 86 (2) , 675-8More Information

Van Kerckhove, C; Luyrink, L; Elma, M S; Maksymowych, W P; Levinson, J E; Larson, M G; Choi, E; Glass, D N  (1990). HLA-DP/DR interaction in children with juvenile rheumatoid arthritis. Immunogenetics, 32 (5) , 364-8

Van Kerckhove, C; Melin-Aldana, H; Elma, M S; Luyrink, L; Donnelly, P; Taylor, J; Maksymowych, W P; Lovell, D J; Choi, E; Glass, D N  (1990). A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis. Immunogenetics, 32 (5) , 304-8

Ghogawala, Z; Choi, E; Daly, K R; Blanco, L R; Griffith, I J; Glimcher, L H  (1989). An intronic 10-base-pair deletion in a class II A beta gene affects RNA processing. Molecular and cellular biology, 9 (10) , 4402-8

Neudorf, S M; Jones, M M; McCarthy, B M; Harmony, J A; Choi, E M  (1990). The CD4 molecule transmits biochemical information important in the regulation of T lymphocyte activity. Cellular immunology, 125 (2) , 301-14

Lee, J S; Sartoris, S; Briata, P; Choi, E; Cullen, C; Lepaslier, D; Yunis, I  (1989). Sequence polymorphism of HLA-DP beta chains. Immunogenetics, 29 (5) , 346-9

Other Publications

Wall, R; Choi, E; Carter, C; Kuehl, M; Rogers, J (1981) RNA processing in immunoglobulin gene expression. Cold Spring Harbor symposia on quantitative biology, 45 Pt 2 ,879-85

Seidman, C E; Bloch, K D; Zisfein, J; Smith, J A; Haber, E; Homcy, C; Duby, A D; Choi, E; Graham, R M; Seidman, J G Molecular studies of the atrial natriuretic factor gene. Hypertension, 7 (3 Pt 2 ) ,I31-4

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231 Albert Sabin Way
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Phone: 513-558-0067
edmund.choi@uc.edu