Edmund M Choi , PhD

B.A.: University of California, Berkeley 1975 (Bacteriology)

Ph.D.: University of California, Los Angeles 1981 (Microbiology and Immunology)

Post Doc: Harvard School of Medicine 1985 (Genetics)

Immunology, Microbiology

1986 -1993 Assistant Professor, Microbiology and Molecular Genetics until 1989 Molecular Genetics, Biochemistry and Microbiology 1989-present, University of Cincinnati College of Medicine, Cincinnati, OH

1993 -To Present Associate Professor, Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH

Grant: #5-P60-AR-44059-05-A0-S0-E0 Investigators:Choi, Edmund 06-01-1996 -05-31-2001 National Institute of Arthritis, Musculoskeletal and Skin Disease Molecular Genotyping and Sequencing Core Role:PI $66,473.00 Closed Level:Federal

Peer Reviewed Publications

Blanco, L; Choi, E M; Connolly, K; Thompson, M R; Bonventre, P F (1990. ) Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. Infection and immunity, , 58 (9 ) ,3020-8

Welch, T R; Beischel, L S; Choi, E M (1989. ) Molecular genetics of C4B deficiency in IgA nephropathy. Human immunology, , 26 (4 ) ,353-63

Griffith, I J; Choi, E M; Glimcher, L H (1987. ) A single base mutation in an I-A alpha-chain gene alters T-cell recognition. Proceedings of the National Academy of Sciences of the United States of America, , 84 (4 ) ,1090-3

Benedict, W F; Baker, M S; Haroun, L; Choi, E; Ames, B N (1977. ) Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. Cancer research, , 37 (7 Pt 1 ) ,2209-13

McCann, J; Choi, E; Yamasaki, E; Ames, B N (1975. ) Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proceedings of the National Academy of Sciences of the United States of America, , 72 (12 ) ,5135-9

Rogers, J; Choi, E; Souza, L; Carter, C; Word, C; Kuehl, M; Eisenberg, D; Wall, R (1981. ) Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains. Cell, , 26 (1 Pt 1 ) ,19-27

Choi, E; Kuehl, M; Wall, R (1980. ) RNA splicing generates a variant light chain from an aberrantly rearranged kappa gene. Nature, , 286 (5775 ) ,776-9

Cohn, L E; Glimcher, L H; Waldmann, R A; Smith, J A; Ben-Nun, A; Seidman, J G; Choi, E (1986. ) Identification of functional regions on the I-Ab molecule by site-directed mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, , 83 (3 ) ,747-51

Glimcher, L H; McKean, D J; Choi, E; Seidman, J G (1985. ) Complex regulation of class II gene expression: analysis with class II mutant cell lines. Journal of immunology (Baltimore, Md. : 1950), , 135 (5 ) ,3542-50

Ben-Nun, A; Choi, E; McIntyre, K R; Leeman, S A; McKean, D J; Seidman, J G; Glimcher, L H (1985. ) DNA-mediated transfer of major histocompatibility class II I-Ab and I-Abm12 genes into B lymphoma cells: molecular and functional analysis of introduced antigens. Journal of immunology (Baltimore, Md. : 1950), , 135 (2 ) ,1456-64

Gasser, D L; Klein, K A; Choi, E; Seidman, J G (1985. ) A new beta-2 microglobulin allele in mice defined by DNA sequencing. Immunogenetics, , 22 (4 ) ,413-6

Seidman, C E; Duby, A D; Choi, E; Graham, R M; Haber, E; Homcy, C; Smith, J A; Seidman, J G (1984. ) The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science (New York, N.Y.), , 225 (4659 ) ,324-6

Murre, C; Choi, E; Weis, J; Seidman, J G; Ozato, K; Liu, L; Burakoff, S J; Reiss, C S (1984. ) Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains. The Journal of experimental medicine, , 160 (1 ) ,167-78

Choi, E; McIntyre, K; Germain, R N; Seidman, J G (1983. ) Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. Science (New York, N.Y.), , 221 (4607 ) ,283-6

Brzezinski, J L; Deka, R; Menon, A G; Glass, D N; Choi, E (2005. ) Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations.International journal of immunogenetics, , 32 (6 ) ,413-20 More Information

Brzezinski, J L; Glass, D N; Choi, E (2001. ) A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes.Genes and immunity, , 2 (5 ) ,290-1 More Information

Cullen, C M; Jameson, S C; DeLay, M; Cottrell, C; Becken, E T; Choi, E; Hirsch, R (1999. ) A divalent major histocompatibility complex/IgG1 fusion protein induces antigen-specific T cell activation in vitro and in vivo.Cellular immunology, , 192 (1 ) ,54-62 More Information

Thompson, S D; Murray, K J; Grom, A A; Passo, M H; Choi, E; Glass, D N (1998. ) Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: evidence for antigenic selection of T cells in the synovium.Arthritis and rheumatism, , 41 (3 ) ,482-97 More Information

Grom, A A; von Knorre, C; Murray, K J; Donnelly, P A; Glass, D N; Choi, E (1996. ) T-cell receptor BV6S1 null alleles and HLA-DR1 haplotypes in polyarticular outcome juvenile rheumatoid arthritis. Human immunology, , 45 (2 ) ,152-6

Lambert, L E; Berling, J S; Thompson, S D; Harton, J A; Bishop, G A; Choi, E (1995. ) Polymorphism in the beta chain of IAq versus IAp influences presentation of protein but not peptide antigens.Cellular immunology, , 165 (2 ) ,202-10 More Information

Thompson, S D; Grom, A A; Bailey, S; Luyrink, L; Giannini, E H; Murray, K; Passo, M H; Lovell, D J; Choi, E; Glass, D N (1995. ) Patterns of T lymphocyte clonal expansion in HLA-typed patients with juvenile rheumatoid arthritis. The Journal of rheumatology, , 22 (7 ) ,1356-64

Cullen, C M; Blanco, L R; Bonventre, P F; Choi, E (1995. ) A toxic shock syndrome toxin 1 mutant that defines a functional site critical for T-cell activation. Infection and immunity, , 63 (6 ) ,2141-6

De Inocencio, J; Choi, E; Glass, D N; Hirsch, R (1995. ) T cell receptor repertoire differences between African Americans and Caucasians associated with polymorphism of the TCRBV3S1 (V beta 3.1) gene. Journal of immunology (Baltimore, Md. : 1950), , 154 (9 ) ,4836-41

Grom, A A; Thompson, S D; Luyrink, L; Passo, M; Choi, E; Glass, D N (1993. ) Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, , 90 (23 ) ,11104-8

Luyrink, L; Gabriel, C A; Thompson, S D; Grom, A A; Maksymowych, W P; Choi, E; Glass, D N (1993. ) Reduced expression of a human V beta 6.1 T-cell receptor allele. Proceedings of the National Academy of Sciences of the United States of America, , 90 (10 ) ,4369-73

Maksymowych, W P; Gabriel, C A; Luyrink, L; Melin-Aldana, H; Elma, M; Giannini, E H; Lovell, D J; Van Kerckhove, C; Leiden, J; Choi, E (1992. ) Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset. Immunogenetics, , 35 (4 ) ,257-62

van Kerckhove, C; Luyrink, L; Taylor, J; Melin-Aldana, H; Balakrishnan, K; Maksymowych, W; Elma, M; Lovell, D; Choi, E; Glass, D N (1991. ) HLA-DQA1*0101 haplotypes and disease outcome in early onset pauciarticular juvenile rheumatoid arthritis. The Journal of rheumatology, , 18 (6 ) ,874-9

Maksymowych, W P; Gabriel, C A; Luyrink, L; Van Kerckhove, C; Leiden, J; Choi, E; Glass, D N (1991. ) Polymorphic markers related to a single Tcrb-V6 gene segment. Immunogenetics, , 33 (4 ) ,281-5

Welch, T R; Beischel, L S; Choi, E; Balakrishnan, K; Bishof, N A (1990. ) Uniparental isodisomy 6 associated with deficiency of the fourth component of complement.The Journal of clinical investigation, , 86 (2 ) ,675-8 More Information

Van Kerckhove, C; Luyrink, L; Elma, M S; Maksymowych, W P; Levinson, J E; Larson, M G; Choi, E; Glass, D N (1990. ) HLA-DP/DR interaction in children with juvenile rheumatoid arthritis. Immunogenetics, , 32 (5 ) ,364-8

Van Kerckhove, C; Melin-Aldana, H; Elma, M S; Luyrink, L; Donnelly, P; Taylor, J; Maksymowych, W P; Lovell, D J; Choi, E; Glass, D N (1990. ) A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis. Immunogenetics, , 32 (5 ) ,304-8

Ghogawala, Z; Choi, E; Daly, K R; Blanco, L R; Griffith, I J; Glimcher, L H (1989. ) An intronic 10-base-pair deletion in a class II A beta gene affects RNA processing. Molecular and cellular biology, , 9 (10 ) ,4402-8

Neudorf, S M; Jones, M M; McCarthy, B M; Harmony, J A; Choi, E M (1990. ) The CD4 molecule transmits biochemical information important in the regulation of T lymphocyte activity. Cellular immunology, , 125 (2 ) ,301-14

Lee, J S; Sartoris, S; Briata, P; Choi, E; Cullen, C; Lepaslier, D; Yunis, I (1989. ) Sequence polymorphism of HLA-DP beta chains. Immunogenetics, , 29 (5 ) ,346-9

Other Publications

Wall, R; Choi, E; Carter, C; Kuehl, M; Rogers, J (1981. ) RNA processing in immunoglobulin gene expression. Cold Spring Harbor symposia on quantitative biology, 45 Pt 2 ,879-85

Seidman, C E; Bloch, K D; Zisfein, J; Smith, J A; Haber, E; Homcy, C; Duby, A D; Choi, E; Graham, R M; Seidman, J G Molecular studies of the atrial natriuretic factor gene. Hypertension, 7 (3 Pt 2 ) ,I31-4

Academic - Office 2251 Medical Sciences Building
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 513-558-0067
edmund.choi@uc.edu