Edmund Choi

Edmund M Choi

Emeritus

Medical Sciences Building

2251

COM Molecular Genetics - 0524

Office 2251 Medical Sciences Building
231 Albert Sabin Way
Cincinnati, Ohio 45267

Education

B.A., University of California, Berkeley 1975 (Bacteriology)

Ph.D., University of California, Los Angeles 1981 (Microbiology and Immunology)

Post Doc, Harvard School of Medicine 1985 (Genetics)

Positions and Work Experience

1986 -1993 Assistant Professor, Microbiology and Molecular Genetics until 1989 Molecular Genetics, Biochemistry and Microbiology 1989-present, University of Cincinnati College of Medicine, Cincinnati, OH

1993 -To Present Associate Professor, Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH

Research and Practice Interests

Immunology, Microbiology

Research Support

Grant: #5-P60-AR-44059-05-A0-S0-E0 Investigators:Choi, Edmund 06-01-1996 -05-31-2001 National Institute of Arthritis, Musculoskeletal and Skin Disease Molecular Genotyping and Sequencing Core Role:PI $66,473.00 Closed Level:Federal

Publications

Peer Reviewed Publications

Blanco, L; Choi, E M; Connolly, K; Thompson, M R; Bonventre, P F (1990. ) Mutants of staphylococcal toxic shock syndrome toxin 1: mitogenicity and recognition by a neutralizing monoclonal antibody. Infection and immunity, , 58 (9 ) ,3020-8

Welch, T R; Beischel, L S; Choi, E M (1989. ) Molecular genetics of C4B deficiency in IgA nephropathy. Human immunology, , 26 (4 ) ,353-63

Griffith, I J; Choi, E M; Glimcher, L H (1987. ) A single base mutation in an I-A alpha-chain gene alters T-cell recognition. Proceedings of the National Academy of Sciences of the United States of America, , 84 (4 ) ,1090-3

Benedict, W F; Baker, M S; Haroun, L; Choi, E; Ames, B N (1977. ) Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. Cancer research, , 37 (7 Pt 1 ) ,2209-13

McCann, J; Choi, E; Yamasaki, E; Ames, B N (1975. ) Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proceedings of the National Academy of Sciences of the United States of America, , 72 (12 ) ,5135-9

Rogers, J; Choi, E; Souza, L; Carter, C; Word, C; Kuehl, M; Eisenberg, D; Wall, R (1981. ) Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains. Cell, , 26 (1 Pt 1 ) ,19-27

Choi, E; Kuehl, M; Wall, R (1980. ) RNA splicing generates a variant light chain from an aberrantly rearranged kappa gene. Nature, , 286 (5775 ) ,776-9

Cohn, L E; Glimcher, L H; Waldmann, R A; Smith, J A; Ben-Nun, A; Seidman, J G; Choi, E (1986. ) Identification of functional regions on the I-Ab molecule by site-directed mutagenesis. Proceedings of the National Academy of Sciences of the United States of America, , 83 (3 ) ,747-51

Glimcher, L H; McKean, D J; Choi, E; Seidman, J G (1985. ) Complex regulation of class II gene expression: analysis with class II mutant cell lines. Journal of immunology (Baltimore, Md. : 1950), , 135 (5 ) ,3542-50

Ben-Nun, A; Choi, E; McIntyre, K R; Leeman, S A; McKean, D J; Seidman, J G; Glimcher, L H (1985. ) DNA-mediated transfer of major histocompatibility class II I-Ab and I-Abm12 genes into B lymphoma cells: molecular and functional analysis of introduced antigens. Journal of immunology (Baltimore, Md. : 1950), , 135 (2 ) ,1456-64

Gasser, D L; Klein, K A; Choi, E; Seidman, J G (1985. ) A new beta-2 microglobulin allele in mice defined by DNA sequencing. Immunogenetics, , 22 (4 ) ,413-6

Seidman, C E; Duby, A D; Choi, E; Graham, R M; Haber, E; Homcy, C; Smith, J A; Seidman, J G (1984. ) The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Science (New York, N.Y.), , 225 (4659 ) ,324-6

Murre, C; Choi, E; Weis, J; Seidman, J G; Ozato, K; Liu, L; Burakoff, S J; Reiss, C S (1984. ) Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains. The Journal of experimental medicine, , 160 (1 ) ,167-78

Choi, E; McIntyre, K; Germain, R N; Seidman, J G (1983. ) Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genes. Science (New York, N.Y.), , 221 (4607 ) ,283-6

Brzezinski, J L; Deka, R; Menon, A G; Glass, D N; Choi, E (2005. ) Variability in TRBV haplotype frequency and composition in Caucasian, African American, Western African and Chinese populations.International journal of immunogenetics, , 32 (6 ) ,413-20

Brzezinski, J L; Glass, D N; Choi, E (2001. ) A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes.Genes and immunity, , 2 (5 ) ,290-1

Cullen, C M; Jameson, S C; DeLay, M; Cottrell, C; Becken, E T; Choi, E; Hirsch, R (1999. ) A divalent major histocompatibility complex/IgG1 fusion protein induces antigen-specific T cell activation in vitro and in vivo.Cellular immunology, , 192 (1 ) ,54-62

Thompson, S D; Murray, K J; Grom, A A; Passo, M H; Choi, E; Glass, D N (1998. ) Comparative sequence analysis of the human T cell receptor beta chain in juvenile rheumatoid arthritis and juvenile spondylarthropathies: evidence for antigenic selection of T cells in the synovium.Arthritis and rheumatism, , 41 (3 ) ,482-97

Grom, A A; von Knorre, C; Murray, K J; Donnelly, P A; Glass, D N; Choi, E (1996. ) T-cell receptor BV6S1 null alleles and HLA-DR1 haplotypes in polyarticular outcome juvenile rheumatoid arthritis. Human immunology, , 45 (2 ) ,152-6

Lambert, L E; Berling, J S; Thompson, S D; Harton, J A; Bishop, G A; Choi, E (1995. ) Polymorphism in the beta chain of IAq versus IAp influences presentation of protein but not peptide antigens.Cellular immunology, , 165 (2 ) ,202-10

Thompson, S D; Grom, A A; Bailey, S; Luyrink, L; Giannini, E H; Murray, K; Passo, M H; Lovell, D J; Choi, E; Glass, D N (1995. ) Patterns of T lymphocyte clonal expansion in HLA-typed patients with juvenile rheumatoid arthritis. The Journal of rheumatology, , 22 (7 ) ,1356-64

Cullen, C M; Blanco, L R; Bonventre, P F; Choi, E (1995. ) A toxic shock syndrome toxin 1 mutant that defines a functional site critical for T-cell activation. Infection and immunity, , 63 (6 ) ,2141-6

De Inocencio, J; Choi, E; Glass, D N; Hirsch, R (1995. ) T cell receptor repertoire differences between African Americans and Caucasians associated with polymorphism of the TCRBV3S1 (V beta 3.1) gene. Journal of immunology (Baltimore, Md. : 1950), , 154 (9 ) ,4836-41

Grom, A A; Thompson, S D; Luyrink, L; Passo, M; Choi, E; Glass, D N (1993. ) Dominant T-cell-receptor beta chain variable region V beta 14+ clones in juvenile rheumatoid arthritis. Proceedings of the National Academy of Sciences of the United States of America, , 90 (23 ) ,11104-8

Luyrink, L; Gabriel, C A; Thompson, S D; Grom, A A; Maksymowych, W P; Choi, E; Glass, D N (1993. ) Reduced expression of a human V beta 6.1 T-cell receptor allele. Proceedings of the National Academy of Sciences of the United States of America, , 90 (10 ) ,4369-73

Maksymowych, W P; Gabriel, C A; Luyrink, L; Melin-Aldana, H; Elma, M; Giannini, E H; Lovell, D J; Van Kerckhove, C; Leiden, J; Choi, E (1992. ) Polymorphism in a T-cell receptor variable gene is associated with susceptibility to a juvenile rheumatoid arthritis subset. Immunogenetics, , 35 (4 ) ,257-62

van Kerckhove, C; Luyrink, L; Taylor, J; Melin-Aldana, H; Balakrishnan, K; Maksymowych, W; Elma, M; Lovell, D; Choi, E; Glass, D N (1991. ) HLA-DQA1*0101 haplotypes and disease outcome in early onset pauciarticular juvenile rheumatoid arthritis. The Journal of rheumatology, , 18 (6 ) ,874-9

Maksymowych, W P; Gabriel, C A; Luyrink, L; Van Kerckhove, C; Leiden, J; Choi, E; Glass, D N (1991. ) Polymorphic markers related to a single Tcrb-V6 gene segment. Immunogenetics, , 33 (4 ) ,281-5

Welch, T R; Beischel, L S; Choi, E; Balakrishnan, K; Bishof, N A (1990. ) Uniparental isodisomy 6 associated with deficiency of the fourth component of complement.The Journal of clinical investigation, , 86 (2 ) ,675-8

Van Kerckhove, C; Luyrink, L; Elma, M S; Maksymowych, W P; Levinson, J E; Larson, M G; Choi, E; Glass, D N (1990. ) HLA-DP/DR interaction in children with juvenile rheumatoid arthritis. Immunogenetics, , 32 (5 ) ,364-8

Van Kerckhove, C; Melin-Aldana, H; Elma, M S; Luyrink, L; Donnelly, P; Taylor, J; Maksymowych, W P; Lovell, D J; Choi, E; Glass, D N (1990. ) A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis. Immunogenetics, , 32 (5 ) ,304-8

Ghogawala, Z; Choi, E; Daly, K R; Blanco, L R; Griffith, I J; Glimcher, L H (1989. ) An intronic 10-base-pair deletion in a class II A beta gene affects RNA processing. Molecular and cellular biology, , 9 (10 ) ,4402-8

Neudorf, S M; Jones, M M; McCarthy, B M; Harmony, J A; Choi, E M (1990. ) The CD4 molecule transmits biochemical information important in the regulation of T lymphocyte activity. Cellular immunology, , 125 (2 ) ,301-14

Lee, J S; Sartoris, S; Briata, P; Choi, E; Cullen, C; Lepaslier, D; Yunis, I (1989. ) Sequence polymorphism of HLA-DP beta chains. Immunogenetics, , 29 (5 ) ,346-9

Other Publications

Wall, R; Choi, E; Carter, C; Kuehl, M; Rogers, J (1981. ) RNA processing in immunoglobulin gene expression. Cold Spring Harbor symposia on quantitative biology, 45 Pt 2 ,879-85

Seidman, C E; Bloch, K D; Zisfein, J; Smith, J A; Haber, E; Homcy, C; Duby, A D; Choi, E; Graham, R M; Seidman, J G Molecular studies of the atrial natriuretic factor gene. Hypertension, 7 (3 Pt 2 ) ,I31-4

Contact Information

Academic - Office 2251 Medical Sciences Building
231 Albert Sabin Way
CincinnatiĀ  Ohio, 45267
Phone: 513-558-0067
edmund.choi@uc.edu