Divaker Choubey

Divaker Choubey

Professor

Kettering Lab Complex

246

COM EH EGMT Choubey Lab - 0056

Department of Environmental Health
Kettering Hall, Room-246
Ohio

Professional Summary

Dr. Choubey’s current research interests include the role of the type I interferon (IFN)-inducible PYHIN-family proteins in chronic inflammation-associated human diseases. The family includes structurally-related murine and human proteins. Most proteins contain the N-terminal pyrin domain (PYD) and C-terminal HIN domain. Upon sensing cytosolic DNA, the PYHIN-family proteins (e.g., murine p204 and human IFI16) either activate the cGAS-STING-TBK1-IRF3 pathway to induce the expression of the IFN-beta or assemble an inflammasome (e.g., murine Aim2 and human AIM2). Activation of an inflammasome results in activation of caspase-1, production of proinflammatory cytokines (e.g., IL-1beta and IL-18), and highly inflammatory cel death by pyroptosis. Constitutive activation of the cGAS-STING pathway or the inflammasome leads to chronic inflammation-associated human diseases.  Specifically, the CHOUBEY laboratory has been interested in investigating the role of the Aim2-like receptor (ALR) and their newly identified inhibitors (such as murine p202 and human IFI16-beta and POP3) in the regulation of inflammation-associated diseases, including Alzheimer's disese (AD). For Dr. Choubey's publications (the h-index 42), follow My Bibliography (My NCBI Collection) link below.
Link: http://www.ncbi.nlm.nih.gov/sites/myncbi/1DGlf- qqau4AS/bibliography/43069278/public/?sort=date&direction=ascending

Education

Postdoctoral Training, Yale University, Dept of MB & B New Haven, CT, 1994 (Molecular Cell Biology)

Ph. D., Indian Institute of Science, India Bangalore, 1986 (Microbiology)

MS, G. B. Pantnagar University, India Pantnagar, 1980 (Major: Biochemistry; Minor: Microbiology)

Positions and Work Experience

09-2010 -12-9999 Professor & Director of Research, Environmental Genetics & Molecular Toxicology, University of Cincinnati, Cincinnati

Research Support

Grant: #R56AI089775 Investigators:Choubey, Divaker 09-01-2011 -08-31-2014 National Institute of Allergy and Infectious Diseases Gender-Specific Role of Aim2 in Inflammation and Autoimmunity Role:PI $392,500.00 Active Level:Federal

Grant: #5 I01 BX001133 Investigators:Divaker Choubey 04-01-2012 -09-30-2017 Department of Veteran's Affair (VA) AIM2 and IFI16 Innate Immune Sensors for Cytosolic DNA in Prostatic Diseases Role:PI 1,000,704 Active Type:Grant Level:National

Grant: #R01 AG025036 Investigators:Choubey, Divaker 05-01-2007 -04-30-2012 National Institute on Aging Role of IFI16 In Cellular Senescence Role:PI $723,381.00 Closed Level:Federal

Grant: #R01 AI066261 Investigators:Choubey, Divaker 03-01-2007 -07-31-2011 National Institute of Allergy and Infectious Diseases Gender-Specific Role of p202 in Lupus Susceptibility Role:PI $586,043.00 Closed Level:Federal

Grant: #SRS 005331 Investigators:Choubey, Divaker 10-01-2007 -01-31-2009 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Ravichandran Panchanathan Role:PI $73,971.00 Closed Level:Federal

Grant: #2 R01 AI066261-05 Investigators:Choubey, Divaker 08-13-2009 -07-31-2012 National Institute of Allergy and Infectious Diseases Gender-Specific Role of p202 in Lupus Susceptibility Role:PI $711,483.00 Closed Level:Federal

Grant: #SRS 006483 Investigators:Choubey, Divaker 10-01-2009 -05-31-2011 Department of Veterans Affairs Intergovernmental Personnel Act Agreement for Eric Dickerson Role:PI $44,350.92 Closed Level:Federal

Grant: #W81XWH-10-1-0367 Investigators:Choubey, Divaker; Dong, Zhongyun; Tarapore, Pheruza 05-15-2010 -05-14-2014 Department of the Army Medical Research and Materiel Command Targeted Delivery of Therapeutic RNA into Prostate Cancers Role:Collaborator $353,250.00 Closed Level:Federal

Grant: #1I01BX004685-01A1 Investigators:Choubey D 10-01-2019 -09-30-2023 Veterans Affair (VA) Autoimmune Nephritis: Role of the AHR-AIM2 Axis in Modulation of Inflammation Role:PI 1,049,112 Pending Type:Grant Level:National

Publications

Peer Reviewed Publications

Alimirah, Fatouma; Panchanathan, Ravichandran; Chen, Jianming; Zhang, Xiang; Ho, Shuk-Mei; Choubey, Divaker (2007. ) Expression of androgen receptor is negatively regulated by p53. Neoplasia (New York, N.Y.), , 9 (12 ) ,1152-9

Panchanathan R, Liu H, Xin D, Choubey D (2014. ) Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING .Innate immunity, , 20 (7 ) ,751-9

Choubey, Divaker; Panchanathan, Ravichandran; Shen, Hui; Duan, Xin (2010. ) Comment on "Development of murine lupus involves the combined genetic contribution of the SLAM and Fc gamma R intervals within the Nba2 autoimmune susceptibility locus".Journal of immunology (Baltimore, Md. : 1950), , 184 (8 ) ,4051-2; author reply

Choubey, Divaker; Moudgil, Kamal D (2011. ) Interferons in autoimmune and inflammatory diseases: regulation and roles.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , 31 (12 ) ,857-65

Panchanathan, Ravichandran; Shen, Hui; Duan, Xin; Rathinam, Vijay A K; Erickson, Loren D; Fitzgerald, Katherine A; Choubey, Divaker (2011. ) Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.Journal of immunology (Baltimore, Md. : 1950), , 186 (12 ) ,6762-70

Xin, Hong; Curry, Jonathan; Johnstone, Ricky W; Nickoloff, Brian J; Choubey, Divaker (2003. ) Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence.Oncogene, , 22 (31 ) ,4831-40

Moudgil, Kamal D; Choubey, Divaker (2011. ) Cytokines in autoimmunity: role in induction, regulation, and treatment.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , 31 (10 ) ,695-703

Panchanathan, Ravichandran; Shen, Hui; Bupp, Melanie Gubbels; Gould, Karen A; Choubey, Divaker (2009. ) Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval.Journal of immunology (Baltimore, Md. : 1950), , 183 (11 ) ,7031-8

Singh, Rekha; Choubey, Divaker; Chen, Jianming; Leehey, David J (2009. ) Inhibition of intracellular angiotensin II formation blocks high glucose effect on mesangial matrix.Regulatory peptides, , 158 (1-3 ) ,103-9

Xin, Hong; Geng, Yanbiao; Pramanik, Rocky; Choubey, Divaker (2003. ) Induction of p202, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H-Ras (Q61L) contributes to cell survival.Journal of cellular biochemistry, , 88 (1 ) ,191-204

Panchanathan R, Liu H, Choubey D (2013. ) Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity .Int Immunol, , 25 (9 ) ,521-9

Panchanathan, Ravichandran; Shen, Hui; Zhang, Xiang; Ho, Shuk-Mei; Choubey, Divaker (2010. ) Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunity.PloS one, , 5 (5 ) ,e10868

Alimirah, Fatouma; Chen, Jianming; Basrawala, Zane; Xin, Hong; Choubey, Divaker (2006. ) DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation.FEBS letters, , 580 (9 ) ,2294-300

Albrecht, Mario; Choubey, Divaker; Lengauer, Thomas (2005. ) The HIN domain of IFI-200 proteins consists of two OB folds.Biochemical and biophysical research communications, , 327 (3 ) ,679-87

Qin, Jian-Zhong; Chaturvedi, Vijaya; Denning, Mitchell F; Bacon, Patricia; Panella, Jeffry; Choubey, Divaker; Nickoloff, Brian J (2002. ) Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes.Oncogene, , 21 (19 ) ,2991-3002

Choubey, Divaker; Panchanathan, Ravichandran (2008. ) Interferon-inducible Ifi200-family genes in systemic lupus erythematosus.Immunology letters, , 119 (1-2 ) ,32-41

Xin, Hong; Pereira-Smith, Olivia M; Choubey, Divaker (2004. ) Role of IFI 16 in cellular senescence of human fibroblasts.Oncogene, , 23 (37 ) ,6209-17

Choubey, Divaker; Kotzin, Brian L (2002. ) Interferon-inducible p202 in the susceptibility to systemic lupus. Frontiers in bioscience : a journal and virtual library, , 7 ,e252-62

Panchanathan R & Choubey D (2013. ) Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity .Mol Immunol, , 53 (1-2 ) ,15-23

Choubey, Divaker; Duan, Xin; Dickerson, Eric; Ponomareva, Larissa; Panchanathan, Ravichandran; Shen, Hui; Srivastava, Ratika (2010. ) Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , 30 (6 ) ,371-80

Xin, Hong; Pramanik, Rocky; Choubey, Divaker (2003. ) Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth.Oncogene, , 22 (31 ) ,4775-85

Veeranki, Sudhakar; Duan, Xin; Panchanathan, Ravichandran; Liu, Hongzhu; Choubey, Divaker (2011. ) IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes.PloS one, , 6 (10 ) ,e27040

Choubey, Divaker; Deka, Ranjan; Ho, Shuk-mei (2008. ) Interferon-inducible IFI16 protein in human cancers and autoimmune diseases. Frontiers in bioscience : a journal and virtual library, , 13 ,598-608

Alimirah, Fatouma; Chen, Jianming; Davis, Francesca J; Choubey, Divaker (2007. ) IFI16 in human prostate cancer.Molecular cancer research : MCR, , 5 (3 ) ,251-9

Chaturvedi, Vijaya; Cesnjaj, Mirjana; Bacon, Patricia; Panella, Jeffery; Choubey, Divaker; Diaz, Manuel O; Nickoloff, Brian J (2003. ) Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes.The American journal of pathology, , 162 (1 ) ,161-70

Veeranki, Sudhakar; Choubey, Divaker (2010. ) Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins.Immunology letters, , 133 (1 ) ,1-5

Kim, Marianne K-H; Mason, Jacqueline M; Li, Chi-Ming; Berkofsky-Fessler, Windy; Jiang, Le; Choubey, Divaker; Grundy, Paul E; Tycko, Benjamin; Licht, Jonathan D (2008. ) A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16. Neoplasia (New York, N.Y.), , 10 (1 ) ,69-78

Xin, Hong; D'Souza, Sanjay; Jørgensen, Trine N; Vaughan, Andrew T; Lengyel, Peter; Kotzin, Brian L; Choubey, Divaker (2006. ) Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950), , 176 (10 ) ,5863-70

Pramanik, Rocky; Qi, Xiaomei; Borowicz, Stanley; Choubey, Divaker; Schultz, Richard M; Han, Jiahuai; Chen, Guan (2003. ) p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity.The Journal of biological chemistry, , 278 (7 ) ,4831-9

Panchanathan, Ravichandran; Duan, Xin; Arumugam, Muthuvel; Shen, Hui; Liu, Hongzhu; Choubey, Divaker (2011. ) Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE.Molecular immunology, , 49 (1-2 ) ,273-80

Panchanathan, Ravichandran; Duan, Xin; Shen, Hui; Rathinam, Vijay A K; Erickson, Loren D; Fitzgerald, Katherine A; Choubey, Divaker (2010. ) Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.Journal of immunology (Baltimore, Md. : 1950), , 185 (12 ) ,7385-93

Alimirah, Fatouma; Chen, Jianming; Xin, Hong; Choubey, Divaker (2006. ) Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein.FEBS letters, , 580 (6 ) ,1659-64

Yin Q, Sester DP, Tian Y, Hsiao Y-S, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H (2013. ) Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation .Cell reports, , 4 (2 ) ,327-39

Veeranki, Sudhakar; Choubey, Divaker (2012. ) Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization.Molecular immunology, , 49 (4 ) ,567-71

Duan, Xin; Ponomareva, Larissa; Veeranki, Sudhakar; Panchanathan, Ravichandran; Dickerson, Eric; Choubey, Divaker (2011. ) Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts.Molecular cancer research : MCR, , 9 (5 ) ,589-602

Shen, Hui; Panchanathan, Ravichandran; Rajavelu, Priya; Duan, Xin; Gould, Karen A; Choubey, Divaker (2010. ) Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunity.Journal of molecular cell biology, , 2 (5 ) ,284-90

Panchanathan, Ravichandran; Liu, Hongzhu; Liu, Hongqi; Fang, Chee-Mun; Erickson, Loren D; Pitha, Paula M; Choubey, Divaker (2012. ) Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis.Journal of immunology (Baltimore, Md. : 1950), , 188 (1 ) ,270-8

Pramanik, Rocky; Jørgensen, Trine N; Xin, Hong; Kotzin, Brian L; Choubey, Divaker (2004. ) Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility.The Journal of biological chemistry, , 279 (16 ) ,16121-7

Choubey, Divaker; Pramanik, Rocky; Xin, Hong (2003. ) Subcellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon-inducible candidate for lupus susceptibility. FEBS letters, , 553 (3 ) ,245-9

Santiago-Raber, Marie-Laure; Baccala, Roberto; Haraldsson, Katarina M; Choubey, Divaker; Stewart, Timothy A; Kono, Dwight H; Theofilopoulos, Argyrios N (2003. ) Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice.The Journal of experimental medicine, , 197 (6 ) ,777-88

Hughes GC & Choubey D (2014. ) Modulation of autoimmune rheumatic diseases by oestrogen and progesterone .Nat Rev Rheumatol, , 10 (12 ) ,740-751

Duan, Xin; Ponomareva, Larissa; Veeranki, Sudhakar; Choubey, Divaker (2011. ) IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway.PloS one, , 6 (5 ) ,e19532

Alimirah, Fatouma; Panchanathan, Ravichandran; Davis, Francesca J; Chen, Jianming; Choubey, Divaker (2007. ) Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress. Neoplasia (New York, N.Y.), , 9 (5 ) ,427-34

Alimirah F, Peng X, Yuan L, Mehta RR, von Knethen A, Choubey D, Mehta RG (2012. ) Crosstalk between the peroxisome proliferator-activated receptor γ (PPARγ) and the vitamin D receptor (VDR) in human breast cancer cells: PPARγ binds to VDR and inhibits 1α,25-dihydroxyvitamin D3 mediated transactivation .Experimental cell research, , 318 (19 ) ,2490-7

Chen, Jianming; Panchanathan, Ravichandran; Choubey, Divaker (2008. ) Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway.Immunology letters, , 118 (1 ) ,13-20

Amrani, Yassine; Tliba, Omar; Choubey, Divaker; Huang, Chien-Da; Krymskaya, Vera P; Eszterhas, Andrew; Lazaar, Aili L; Panettieri, Reynold A (2003. ) IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway.American journal of physiology. Lung cellular and molecular physiology, , 284 (6 ) ,L1063-71

Ponomareva L, Liu H, Duan X, Dickerson E, Shen H, Panchanathan R, Choubey D (2013. ) AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer .Mol Cancer Res, , 11 (10 ) ,1193-202

Choubey D (2012. ) DNA-responsive inflammasomes and their regulators in autoimmunity .Clinical immunology (Orlando, Fla.), , 142 (3 ) ,223-31

Zimmerman, Mary; Yang, Dafeng; Hu, Xiaolin; Liu, Feiyan; Singh, Nagendra; Browning, Darren; Ganapathy, Vadivel; Chandler, Phillip; Choubey, Divaker; Abrams, Scott I; Liu, Kebin (2010. ) IFN-? upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells.PloS one, , 5 (11 ) ,e14076

Choubey D (2012. ) Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility .Immunology letters, , 147 (1-2 ) ,10-7

Song, Lynda Li; Alimirah, Fatouma; Panchanathan, Ravichandran; Xin, Hong; Choubey, Divaker (2008. ) Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53.Molecular cancer research : MCR, , 6 (11 ) ,1732-41

Choubey, Divaker; Panchanathan, Ravichandran; Duan, Xin; Liu, Hongqi; Liu, Hongzhu (2011. ) Emerging roles for the interferon-inducible p200-family proteins in sex bias in systemic lupus erythematosus.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , 31 (12 ) ,893-906

Choubey, Divaker; Panchanathan, Ravichandran; Liu, Hongzhu (2011. ) Comment on "The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility".Journal of immunology (Baltimore, Md. : 1950), , 187 (8 ) ,3909; author reply 3

Song, Lynda Li; Ponomareva, Larissa; Shen, Hui; Duan, Xin; Alimirah, Fatouma; Choubey, Divaker (2010. ) Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene.PloS one, , 5 (1 ) ,e8569

Panchanathan, Ravichandran; Xin, Hong; Choubey, Divaker (2008. ) Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice. Journal of immunology (Baltimore, Md. : 1950), , 180 (9 ) ,5927-34

Panchanathan R, Liu H, Choubey D (2015. ) Activation of p53 in Human and Murine Cells by DNA-Damaging Agents Differentially Regulates Aryl Hydrocarbon Receptor Levels .Int J Toxicol, , 34 (3 ) ,242

Khanal T, Kim D, Johnson A, Choubey D, Kim K (2015. ) Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter .Toxicol Lett, , 237 (3 ) ,228-36

Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. (2015. ) Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells .Mol Cell Endocrinol, , 415 ,45 -55

Klionsky DJ et al. (2016. ) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) .Autophagy, , 12 (1 ) ,1

Panchanathan R, Liu H, Choubey D (2016. ) Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation .Oncotarget, , 73 (19 ) ,28183

Choubey D & Panchanathan R (2015. ) Comment on "Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice" .Journal of immunology (Baltimore, Md. : 1950), , 195 (10 ) ,4551-2

Choubey D & Panchanathan R (2016. ) IFI16, an amplifier of DNA-damage response: role in cellular senescence and aging-associated inflammatory diseases (a review) .Ageing Research Reviews, , 28 ,27

Hsieh, Heidi; Vignesh, Kavitha Subramanian; Deepe, George S; Choubey, Divaker; Shertzer, Howard G; Genter, Mary Beth (2016. ) Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora. Toxicology in vitro : an international journal published in association with BIBRA, , 35 ,24-30

Choubey, Divaker; Panchanathan, Ravichandran (2017. ) Absent in Melanoma 2 proteins in SLE.Clinical immunology (Orlando, Fla.), , 176 ,42-48

Choubey D & Panchanathan R (2019. ) Interferon (IFN)-inducible Absent in Melanoma 2 proteins in the negative regulation of the type I IFN response: Implications for lupus nephritis .Cytokine, , S1043-4666 (19 ) ,30086-9

Choubey D (2016. ) Absent in melanoma 2 proteins in the development of cancer .Cellular & Molecular Life Sciences, , 73 (23 ) ,4383

Choubey, Divaker; Panchanathan, Ravichandran (2016. ) IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases.Ageing research reviews, , 28 ,27-36

Choubey D & Panchanathan R (2017. ) Absent in Melanoma 2 proteins in SLE .Clin Immunol, , 176 ,42

Panchanathan, Ravichandran; Liu, Hongzhu; Choubey, Divaker (2016. ) Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation.Oncotarget, , 7 (19 ) ,28183-94

Panchanathan, Ravichandran; Liu, Hongzhu; Leung, Yuet-Kin; Ho, Shuk-mei; Choubey, Divaker (2015. ) Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells.Molecular and cellular endocrinology, , 415 ,45-55

Choubey D (2019. ) Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease .Journal of Neuroinflammation, , 16 ,236

Choubey, Divaker; Panchanathan, Ravichandran (2020. ) Interferon (IFN)-inducible Absent in Melanoma 2 proteins in the negative regulation of the type I IFN response: Implications for lupus nephritis.Cytokine, , 132 ,154682

Choubey, Divaker (2019. ) Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer's disease.Journal of neuroinflammation, , 16 (1 ) ,236

Panchanathan R, Ramalingam V, Liu H, Choubey D (2021. ) Human Prostate Epithelial Cells Activate the AIM2 Inflammasome upon Cellular Senescence: Role of POP3 Protein in Aging-related Prostatic Inflammation (Research Article) .Life, , Special Issue ,

Service

Journal of Immunology (Editorial ) Editorial Board Member Type:Editorial Service Level:National 07-01-2017 -06-30-2021

Department of Environmental & Public Health Sciences (Research ) Director Type:Departmental Service 07-15-2013 -To Present

Department of Environmental & Public Health Sciences (Environmental Genetics & Molecular Toxicology Division ) Director Type:Departmental Service 07-01-2014 -To Present

Dept. of Environmental & Public Health Sciences (EGMT Graduate Studies ) Director Type:Departmental Service Level:Department 07-01-2020 -To Present

Post Graduate Training and Education

01-26-1986-06-30-1994 Research Scientist, Molecular & Cellular Biology of Interferon Signaling., Yale University, , New Haven, CT

Contact Information

Academic - Department of Environmental Health
Kettering Hall, Room-246
Ohio, Phone: 513-558-1014
Divaker.Choubey@uc.edu