Robert Cohen

Robert M Cohen

Professor

Medical Sciences Building

7165

COM IM Endocrinology Division - 0547

Medical Sciences Building
231 Albert Sabin Way, ML 0547
Cincinnati, Ohio 45267-0547

Professional Summary

Dr. Cohen is a Professor in the Division of Endocrinology, Diabetes & Metabolism. Dr. Cohen is Chair of the University of Cincinnati-Cincinnati VA Satellite General Clinical Research Center Scientific Advisory Committee. He is ABIM certified in Internal Medicine and in Endocrinology and Metabolism, a fellow of the American College of Physicians and a member of the American Diabetes Association, Endocrine Society and American Association of Clinical Endocrinologists.

Education

Bachelor's Degree, Amherst College 1974

Medical Degree, University of Rochester School of Medicine & Dentistry 1978

Internship & Residency, Rush-Presbyterian-St. Luke's Medical Center 1981 (Department of Medicine )

Fellowship, University of Chicago 1984 (Section of Endocrinology, Department of Medicine )

Positions and Work Experience

05-1991 -To Present Associate Professor (with tenure), Division of Endocrinology/Metabolism, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH

09-1992 -07-1995 Interim Director, Division of Endocrinology/Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, OH

09-1992 -07-1994 Acting Chief, Endocrinology SErvice, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH

01-1991 -To Present Associate Program Director, Children's Hospital-University of Cincinnati General Clinical Research Center, Cincinnati, OH

07-1989 -To Present Director, University of Cincinnati Hospital Diabetes Clinic, Cincinnati, OH

04-1988 -12-1990 Associate Program Director, General Clinical Research Center - University of Cincinnati, Cincinnati, OH

01-1985 -05-1991 Assistant Professor, Division of Endocrinology/Metabolism, Department of Medicine, University of Cincinnati, Cincinnati, OH

07-1984 -12-1984 Research Associate and Attending Physician, Section of Endocrinology, Department of Medicine, University of Chicago, Chicago, IL

Research and Practice Interests

Board certified in Internal Medicine and Endocrinology with Particular Interest in Diabetes, Clinical Investigation, Endocrinology, Non-glycemic Mechanisms Affecting Hemoglobin A1c and Their Possible Role in the Complications of Diabetes, Diabetes Clinical Trials, Including the ACCORD (action to control cardiovascular risk in diabetes) Trial.

Clinical Focus

Endocrinology

Specialities

Endocrinology-Diabetes and Metabolism

Internal Medicine

Certifications

American Board of Internal Medicine (Endocrinology and Metabolism)

11/08/1983

American Board of Internal Medicine

09/16/1981

Research Support

Grant: #R01 DK63088 Investigators:Cohen 2009 -2014 NIH Red Cell Lifespan, The Glycation Gap and Diabetic Complications Role:P.I.

Grant: #R01 DK074361 Investigators:Robert Cohen, Timothy Cromblehome 2005 -2009 NIH Endothelial Precursor Cell Biology in Type 1 Diabetes Role:Co-P.I.

Grant: #R01 DK63088 Investigators:Cohen 2002 -2006 NIH The Glycosylation Gap and Diabetic Complications Role:P.I. $250,000/year

Investigators:Cohen 2002 -2005 Juvenile Diabetes Research Foundation The Glycosylation gap: Implications for Diabetic Complications Role:P.I. $154,794

Investigators:Cohen 2000 -2001 Central Ohio Diabetes Association Research Grant

Investigators:Cohen 1999 -2010 NHLBI Contract ACCORD Trial Role:P.I.

Grant: #M01 RR08084 Investigators:Robert Cohen, Thomas Boat 1999 -2006 NIH General Clinical Research Center

Grant: #RFA DK00-008 Investigators:Cohen 2000 -2005 NIH Landmarks in the Progression to Type II Diabetes Role:P.I.

Grant: #N01-HC-95181 Investigators:Cohen, Robert 09-30-1999 -12-31-2010 National Heart, Lung and Blood Institute Prevention of Cardiovascular Disease in Diabetes Mellitus Role:PI $2,492,517.00 Closed Level:Federal

Grant: #R01 DK074361 Investigators:Cohen, Robert 09-30-2005 -07-31-2009 National Inst of Diabetes and Digestive and Kidney Disease Endothelial Progenitor Cell Biology in Type 1 Diabetes Role:PI $147,894.00 Closed Level:Federal

Grant: #CHMC 482 / R01 DK074055 Investigators:Cohen, Robert 09-30-2005 -07-31-2009 National Inst of Diabetes and Digestive and Kidney Disease Endothelial Progenitor Cell Biology in Type 1 Diabetes Role:PI $133,618.00 Closed Level:Federal

Grant: #1-2002-560-01-A0-S0-E0 Investigators:Cohen, Robert 07-01-2002 -09-29-2002 Juvenile Diabetes Research Foundation International The Glucosylation Gap: Implications for Diabetic Complications Role:PI $190,000.00 Closed Level:Private Non-Profit

Grant: #CODA-10-01-A0-S0-E0 Investigators:Cohen, Robert 06-01-2000 -07-31-2001 Central Ohio Diabetes Association Heterogeneity of Erythrocyte Glucose Transport and Its Implications for Apparent Glycemic Control in Patients with Type 2 Diabetes Role:PI $35,000.00 Closed Level:Private Non-Profit

Grant: #5-R01-DK-59183-05-A0-S0-E0 Investigators:Cohen, Robert 09-30-2001 -08-31-2005 National Inst of Diabetes and Digestive and Kidney Disease Landmarks in the Progression to Type II Diabetes Role:PI $54,238.00 Closed Level:Federal

Grant: #5-M01-RR-08084-06-A0-S0-E0 Investigators:Cohen, Robert 12-01-2001 -11-30-2006 National Center for Research Resources General Clinical Research Center Role:PI $926,727.00 Closed Level:Federal

Grant: #R01-DK-063088 Investigators:Cohen, Robert 09-30-2002 -07-31-2007 National Inst of Diabetes and Digestive and Kidney Disease The Glycosylation Gap and Diabetic Complications Role:PI $1,468,200.00 Closed Level:Federal

Grant: #5-R01-DK-46519-05-A0-S0-E0 Investigators:Cohen, Robert 09-01-1994 -08-31-1999 National Inst of Diabetes and Digestive and Kidney Disease Biochemical Predictors of NIDDM in Women Role:PI $204,426.00 Closed Level:Federal

Grant: #5-M01-RR-08084-08-A0-S0-E0 Investigators:Cohen, Robert 04-01-1999 -11-30-2001 National Center for Research Resources General Clinical Research Center Core Lab Role:PI $621,346.00 Closed Level:Federal

Grant: #Accordion-UC / HHSN268201100027C Investigators:Cohen, Robert 01-01-2011 -03-31-2013 National Heart, Lung and Blood Institute ACCORD follow-On Study (ACCORDION) Role:PI $48,733.00 Active Level:Federal

Grant: #EYE-Cincinnati RES507570 / HHSN268201100027C Investigators:Cohen, Robert 01-01-2011 -06-22-2013 National Heart, Lung and Blood Institute ACCORDION - Eye Study Role:PI $12,217.00 Active Level:Federal

Grant: #RES507653 / HHSN268201100027C Investigators:Cohen, Robert 07-01-2012 -06-30-2013 National Heart, Lung and Blood Institute ACCORDION - Option 1 Role:PI $41,367.00 Active Level:Federal

Grant: #S-GRD1213-KR6 \ U01DK098246 Investigators:Cohen, Robert; Dalessio, David 01-01-2013 -07-31-2017 National Inst of Diabetes and Digestive and Kidney Disease The Glycemia Reduction Approaches for Diabetes: A Comparative Effectiveness Study Role:PI $198,393.00 Active Level:Federal

Grant: #RES508173 / HHSN268201100017C Investigators:Cohen, Robert 04-01-2013 -11-30-2014 National Heart, Lung and Blood Institute ACCORDION - Eye Study - Modification to contract Role:PI $16,600.00 Active Level:Federal

Grant: #5007467-SERV \ R01DK076092 Investigators:Cohen, Robert; Dalessio, David 09-01-2012 -07-31-2017 National Inst of Diabetes and Digestive and Kidney Disease The Role of Vitamin D in Established Type 2 Diabetes Role:PI $297,796.00 Active Level:Federal

Grant: #RES508800 Investigators:Cohen, Robert 12-01-2013 -11-30-2014 National Heart, Lung and Blood Institute ACCORDION - Option 2 Role:PI $53,931.02 Active Level:Federal

Grant: #GWU S-GRD1516-AC6 SUB u01dk098246 Investigators:Cohen, Robert 08-01-2015 -07-31-2016 National Inst of Diabetes and Digestive and Kidney Disease Glycemia Reducation Approaches in Diabetes: A comparative effectiveness Study (GRADE) Progress report- year 4 Role:PI $207,270.00 Awarded Level:Federal

Grant: #GWU GRADE sub R01DK104845 Investigators:Cohen, Robert 09-01-2015 -03-31-2020 National Inst of Diabetes and Digestive and Kidney Disease Emotional Distress in a Comparative Effectiveness Trial of Diabetes Treatments Role:PI $44,297.11 Active Level:Federal

Grant: #GWU S-GRD1617-AT6 Investigators:Cohen, Robert 08-01-2016 -07-31-2017 National Inst of Diabetes and Digestive and Kidney Disease Glycemia Reduction Approaches in Diabetes: A comparative effectiveness study (GRADE) Progress report - year 4 Role:PI $363,926.00 Active Level:Federal

Grant: #GW GRADE 2017-18 sub U01DK098246 Investigators:Cohen, Robert 09-06-2017 -07-31-2018 National Inst of Diabetes and Digestive and Kidney Disease Glycemia Reduction Approaches in Diabetes: A comparative effectiveness study (GRADE) Role:PI $492,288.00 Active Level:Federal

Grant: #S-GRD1819-SC6 / U01DK098246 Investigators:Cohen, Robert 08-01-2018 -07-31-2019 National Inst of Diabetes and Digestive and Kidney Disease Glycemia Reduction Approaches in Diabetes: A comparative effectiveness study (GRADE) Role:PI $437,733.00 Awarded Level:Federal

Grant: #S-GRD1920-SC6 / U01DK098246 Investigators:Cohen, Robert 08-01-2019 -07-31-2020 National Institutes of Health Glycemia Reduction Approaches in Diabetes: A comparative effectiveness study (GRADE) RPPR Role:PI $434,985.00 Active Level:Federal

Grant: #R01DK123330 Investigators:Cohen, Robert 07-01-2020 -03-31-2025 National Inst of Diabetes and Digestive and Kidney Disease Towards optimizing diabetes management and diagnosis by personalizing HbA1c targets Role:PI $728,945.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Herman, William H; Cohen, Robert M (2012. ) Racial and Ethnic Differences in the Relationship between HbA1c and Blood Glucose: Implications for the Diagnosis of Diabetes.The Journal of Clinical Endocrinology and Metabolism, , 97 (4 ) ,1067-72

Gerstein, Hertzel C; Miller, Michael E; Genuth, Saul; Ismail-Beigi, Faramarz; Buse, John B; Goff, David C; Probstfield, Jeffrey L; Cushman, William C; Ginsberg, Henry N; Bigger, J Thomas; Grimm, Richard H; Byington, Robert P; Rosenberg, Yves D; Friedewald, William T (2011. ) Long-term effects of intensive glucose lowering on cardiovascular outcomes.The New England Journal of Medicine, , 364 (9 ) ,818-28

Riddle, Matthew C; Ambrosius, Walter T; Brillon, David J; Buse, John B; Byington, Robert P; Cohen, Robert M; Goff, David C; Malozowski, Saul; Margolis, Karen L; Probstfield, Jeffrey L; Schnall, Adrian; Seaquist, Elizabeth R (2010. ) Epidemiologic relationships between A1C and all-cause mortality during a median 3.4-year follow-up of glycemic treatment in the ACCORD trial.Diabetes Care, , 33 (5 ) ,983-90

Ambrosius, Walter T; Danis, Ronald P; Goff, David C; Greven, Craig M; Gerstein, Hertzel C; Cohen, Robert M; Riddle, Matthew C; Miller, Michael E; Buse, John B; Bonds, Denise E; Peterson, Kevin A; Rosenberg, Yves D; Perdue, Letitia H; Esser, Barbara A; Seaquist, Lea A; Felicetta, James V; Chew, Emily Y (2010. ) Lack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy.Archives of Ophthalmology, , 128 (3 ) ,312-8

Cohen, Robert M; Smith, Eric P (2008. ) Frequency of HbA1c discordance in estimating blood glucose control.Current opinion in clinical nutrition and metabolic care, , 11 (4 ) ,512-7

Lindsell, Christopher J; Franco, Robert S; Smith, Eric P; Joiner, Clinton H; Cohen, Robert M (2008. ) A method for the continuous calculation of the age of labeled red blood cells.American journal of hematology, , 83 (6 ) ,454-7

El Khoury, Marc; Yousuf, Farheen; Martin, Vincent; Cohen, Robert M (2008. ) Pseudohypoglycemia: a cause for unreliable finger-stick glucose measurements. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, , 14 (3 ) ,337-9

Cohen, Robert M; LeCaire, Tamara J; Lindsell, Christopher J; Smith, Eric P; D'Alessio, Donn J (2008. ) Relationship of prospective GHb to glycated serum proteins in incident diabetic retinopathy: implications of the glycation gap for mechanism of risk prediction.Diabetes care, , 31 (1 ) ,151-3

Cohen, Robert M; Snieder, Harold; Lindsell, Christopher J; Beyan, Huriya; Hawa, Mohammed I; Blinko, Stuart; Edwards, Raymond; Spector, Timothy D; Leslie, R David G (2006. ) Evidence for independent heritability of the glycation gap (glycosylation gap) fraction of HbA1c in nondiabetic twins.Diabetes care, , 29 (8 ) ,1739-43

Cohen, Robert M; Franco, Robert S; Joiner, Clinton H (2004. ) Is poor glycemic control associated with reduced red blood cell lifespan? .Diabetes care, , 27 (4 ) ,1013-4

Cohen, Robert M; Ramlo-Halsted, Barbara A (2002. ) How do the new insulin secretagogues compare? .Diabetes care, , 25 (8 ) ,1472-3

Nikiforova, M N; Nikiforov, Y E; Biddinger, P; Gnepp, D R; Grosembacher, L A; Wajchenberg, B L; Fagin, J A; Cohen, R M (1999. ) Frequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours. Clinical endocrinology, , 51 (1 ) ,27-33

Katz, R J; Ratner, R E; Cohen, R M; Eisenhower, E; Verme, D (1996. ) Are insulin and proinsulin independent risk markers for premature coronary artery disease ? .Diabetes, , 45 (6 ) ,736-41

Rymaszewski, Z; Szymanski, P T; Abplanalp, W A; Myatt, L; Di Salvo, J; Cohen, R M (1992. ) Human retinal vascular cells differ from umbilical cells in synthetic functions and their response to glucose. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), , 199 (2 ) ,183-91

Cohen, R M; Abplanalp, W A (1991. ) Resistance of growth hormone secretion to somatostatin in men with type I diabetes mellitus. Diabetes, , 40 (10 ) ,1251-8

Cohen, R M; Camus, F (1988. ) Update on insulinomas or the case of the missing (pro)insulinoma. Diabetes care, , 11 (6 ) ,506-8

Glauber, H S; Henry, R R; Wallace, P; Frank, B H; Galloway, J A; Cohen, R M; Olefsky, J M (1987. ) The effects of biosynthetic human proinsulin on carbohydrate metabolism in non-insulin-dependent diabetes mellitus.The New England journal of medicine, , 316 (8 ) ,443-9

Given, B D; Cohen, R M; Shoelson, S E; Frank, B H; Rubenstein, A H; Tager, H S (1985. ) Biochemical and clinical implications of proinsulin conversion intermediates.The Journal of clinical investigation, , 76 (4 ) ,1398-405

Cohen, R M; Nakabayashi, T; Blix, P M; Rue, P A; Shoelson, S E; Root, M A; Frank, B H; Revers, R R; Rubenstein, A H (1985. ) A radioimmunoassay for circulating human proinsulin. Diabetes, , 34 (1 ) ,84-91

Bergenstal, R M; Cohen, R M; Lever, E; Polonsky, K; Jaspan, J; Blix, P M; Revers, R; Olefsky, J M; Kolterman, O; Steiner, K (1984. ) The metabolic effects of biosynthetic human proinsulin in individuals with type I diabetes. The Journal of clinical endocrinology and metabolism, , 58 (6 ) ,973-9

Madsen, O D; Cohen, R M; Fitch, F W; Rubenstein, A H; Steiner, D F (1983. ) The production and characterization of monoclonal antibodies specific for human proinsulin using a sensitive microdot assay procedure. Endocrinology, , 113 (6 ) ,2135-44

Kruse, V; Heding, L G; Jørgensen, K H; Tronier, B; Christensen, M; Thim, L; Frank, B H; Root, M A; Cohen, R M; Rubenstein, A H (1984. ) Human proinsulin standards. Diabetologia, , 27 (3 ) ,414-5

Cohen, Robert M; Haggerty, Shannon; Herman, William H (2010. ) HbA1c for the diagnosis of diabetes and prediabetes: is it time for a mid-course correction?.The Journal of Clinical Endocrinology and Metabolism, , 95 (12 ) ,5203-6

Margolis, David J; Hoffstad, Ole; Thom, Stephen; Bilker, Warren; Maldonado, Arturo R; Cohen, Robert M; Aronow, Bruce J; Crombleholme, Timothy The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 18 (5 ) ,445-51

Ismail-Beigi, Faramarz; Craven, Timothy; Banerji, Mary Ann; Basile, Jan; Calles, Jorge; Cohen, Robert M; Cuddihy, Robert; Cushman, William C; Genuth, Saul; Grimm, Richard H; Hamilton, Bruce P; Hoogwerf, Byron; Karl, Diane; Katz, Lois; Krikorian, Armand; O (2010. ) Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.Lancet, , 376 (9739 ) ,419-30

ACCORD Study Group; ACCORD Eye Study Group, Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue LH, Goff DC Jr, Cushman WC, Ginsberg HN, Elam MB, Genuth S, Gerstein HC, Schubart U, Fine LJ. (2010. ) Effects of medical therapies on retinopathy progression in type 2 diabetes.The New England Journal of Medicine, , 363 (3 ) ,233-44

Herman, William H; Cohen, Robert M (2010. ) Hemoglobin A1c: teaching a new dog old tricks.Annals of Internal Medicine, , 152 (12 ) ,815-7

ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, Crouse JR 3rd, Leiter LA, Linz P, Friedewald WT, Buse JB, Gerstein HC, Probstfield J, Grimm RH, Ismail-Beigi F, Bigger JT, Goff DC Jr, Cushman WC, Simons-Morton DG, Byington RP (2010. ) Effects of combination lipid therapy in type 2 diabetes mellitus.The New England Journal of Medicine, , 362 (17 ) ,1563-74

, ; Cushman, William C; Evans, Gregory W; Byington, Robert P; Goff, David C; Grimm, Richard H; Cutler, Jeffrey A; Simons-Morton, Denise G; Basile, Jan N; Corson, Marshall A; Probstfield, Jeffrey L; Katz, Lois; Peterson, Kevin A; Friedewald, William T; Buse, John B; Bigger, J Thomas; Gerstein, Hertzel C; Ismail-Beigi, Faramarz (2010. ) Effects of intensive blood-pressure control in type 2 diabetes mellitus.The New England journal of medicine, , 362 (17 ) ,1575-85

Calles-Escandón, Jorge; Lovato, Laura C; Simons-Morton, Denise G; Kendall, David M; Pop-Busui, Rodica; Cohen, Robert M; Bonds, Denise E; Fonseca, Vivian A; Ismail-Beigi, Faramarz; Banerji, Mary Ann; Failor, Alan; Hamilton, Bruce (2010. ) Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.Diabetes care, , 33 (4 ) ,721-7

Cohen, Robert M; Franco, Robert S; Khera, Paramjit K; Smith, Eric P; Lindsell, Christopher J; Ciraolo, Peter J; Palascak, Mary B; Joiner, Clinton H (2008. ) Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c.Blood, , 112 (10 ) ,4284-91

Khera, Paramjit K; Joiner, Clinton H; Carruthers, Anthony; Lindsell, Christopher J; Smith, Eric P; Franco, Robert S; Holmes, Yancey R; Cohen, Robert M (2008. ) Evidence for interindividual heterogeneity in the glucose gradient across the human red blood cell membrane and its relationship to hemoglobin glycation.Diabetes, , 57 (9 ) ,2445-52

Smith, Eric P; Specker, Bonny; Bachrach, Bert E; Kimbro, K S; Li, X J; Young, Marian F; Fedarko, Neal S; Abuzzahab, M J; Frank, Graeme R; Cohen, Robert M; Lubahn, Dennis B; Korach, Kenneth S (2008. ) Impact on bone of an estrogen receptor-alpha gene loss of function mutation.The Journal of clinical endocrinology and metabolism, , 93 (8 ) ,3088-96

Cohen, Robert M; Joiner, Clinton H; Franco, Robert S (2008. ) Discordant HbA1c results: the hoofbeats increase.The Journal of pediatrics, , 153 (1 ) ,7-9

, ; Gerstein, Hertzel C; Miller, Michael E; Byington, Robert P; Goff, David C; Bigger, J Thomas; Buse, John B; Cushman, William C; Genuth, Saul; Ismail-Beigi, Faramarz; Grimm, Richard H; Probstfield, Jeffrey L; Simons-Morton, Denise G; Friedewald, William T (2008. ) Effects of intensive glucose lowering in type 2 diabetes.The New England journal of medicine, , 358 (24 ) ,2545-59

Cohen, Robert M (2007. ) A1C: does one size fit all?.Diabetes care, , 30 (10 ) ,2756-8

Gerstein, Hertzel C; Riddle, Matthew C; Kendall, David M; Cohen, Robert M; Goland, Robin; Feinglos, Mark N; Kirk, Julienne K; Hamilton, Bruce P; Ismail-Beigi, Faramarz; Feeney, Patricia (2007. ) Glycemia treatment strategies in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.The American journal of cardiology, , 99 (12A ) ,34i-43i

Schulze, M B; Solomon, C G; Rifai, N; Cohen, R M; Sparrow, J; Hu, F B; Manson, J E (2005. ) Hyperproinsulinaemia and risk of Type 2 diabetes mellitus in women.Diabetic medicine : a journal of the British Diabetic Association, , 22 (9 ) ,1178-84

Dolan, Lawrence M; Bean, Judy; D'Alessio, David; Cohen, Robert M; Morrison, John A; Goodman, Elizabeth; Daniels, Stephen R (2005. ) Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents.The Journal of pediatrics, , 146 (6 ) ,751-8

Klein, David J; Aronson Friedman, Lisa; Harlan, William R; Barton, Bruce A; Schreiber, George B; Cohen, Robert M; Harlan, Linda C; Morrison, John A (2004. ) Obesity and the development of insulin resistance and impaired fasting glucose in black and white adolescent girls: a longitudinal study. Diabetes care, , 27 (2 ) ,378-83

Cohen, Robert M; Holmes, Yancey R; Chenier, Thomas C; Joiner, Clinton H (2003. ) Discordance between HbA1c and fructosamine: evidence for a glycosylation gap and its relation to diabetic nephropathy. Diabetes care, , 26 (1 ) ,163-7

Cohen, R M (2000. ) Implications of linking pharmacy and laboratory data to assess diabetes care. Diabetes care, , 23 (11 ) ,1603-4

Tiao, G M; Martin, J; Weber, F L; Cohen, R M; Hanto, D W (1999. ) Addisonian crisis in a liver transplant patient due to fluconazole withdrawal. Clinical transplantation, , 13 (1 Pt 1 ) ,62-4

Chiasson, J L; Josse, R G; Leiter, L A; Mihic, M; Nathan, D M; Palmason, C; Cohen, R M; Wolever, T M (1996. ) The effect of acarbose on insulin sensitivity in subjects with impaired glucose tolerance. Diabetes care, , 19 (11 ) ,1190-3

Klein, D J; Cohen, R M; Rymaszewski, Z (1995. ) Proteoglycan synthesis by bovine myocardial endothelial cells is increased by long-term exposure to high concentrations of glucose.Journal of cellular physiology, , 165 (3 ) ,493-502

Klonoff, D C; Barrett, B J; Nolte, M S; Cohen, R M; Wyderski, R (1995. ) Hypoglycemia following inadvertent and factitious sulfonylurea overdosages. Diabetes care, , 18 (4 ) ,563-7

Smith, E P; Boyd, J; Frank, G R; Takahashi, H; Cohen, R M; Specker, B; Williams, T C; Lubahn, D B; Korach, K S (1994. ) Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.The New England journal of medicine, , 331 (16 ) ,1056-61

Cohen, R M; Nathan, D M; Clements, R S (1992. ) Hyperproinsulinemia in type II diabetes. Diabetes care, , 15 (5 ) ,723-4

Arshad, M A; Bhadra, S; Cohen, R M; Subbiah, M T (1991. ) Plasma lipoprotein peroxidation potential: a test to evaluate individual susceptibility to peroxidation. Clinical chemistry, , 37 (10 Pt 1 ) ,1756-8

Rymaszewski, Z; Cohen, R M; Chomczynski, P (1991. ) Human growth hormone stimulates proliferation of human retinal microvascular endothelial cells in vitro. Proceedings of the National Academy of Sciences of the United States of America, , 88 (2 ) ,617-21

Menon, R K; Cohen, R M; Sperling, M A; Cutfield, W S; Mimouni, F; Khoury, J C (1990. ) Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia.The New England journal of medicine, , 323 (5 ) ,309-15

Camus-Bablon, F; Cohen, R M; Berk, M A; Perisutti, G; Hunter, K; Frohman, L A (1990. ) Alterations in circulating human chorionic gonadotropin free alpha-subunit in insulin-dependent diabetic pregnancy: correlation with maternal characteristics. The Journal of clinical endocrinology and metabolism, , 71 (1 ) ,46-52

Cohen, R M; Licinio, J; Polonsky, K S; Galloway, J A; Frank, B H; Cherrington, A D; Rubenstein, A H (1987. ) The effect of biosynthetic human proinsulin on the hepatic response to glucagon in insulin-deficient diabetes. The Journal of clinical endocrinology and metabolism, , 64 (3 ) ,476-81

Cohen, R M; Given, B D; Licinio-Paixao, J; Provow, S A; Rue, P A; Frank, B H; Root, M A; Polonsky, K S; Tager, H S; Rubenstein, A H (1986. ) Proinsulin radioimmunoassay in the evaluation of insulinomas and familial hyperproinsulinemia. Metabolism: clinical and experimental, , 35 (12 ) ,1137-46

Glauber, H S; Revers, R R; Henry, R; Schmeiser, L; Wallace, P; Kolterman, O G; Cohen, R M; Rubenstein, A H; Galloway, J A; Frank, B H (1986. ) In vivo deactivation of proinsulin action on glucose disposal and hepatic glucose production in normal man. Diabetes, , 35 (3 ) ,311-7

Herold, K C; Polonsky, K S; Cohen, R M; Levy, J; Douglas, F (1985. ) Variable deterioration in cortical function during insulin-induced hypoglycemia. Diabetes, , 34 (7 ) ,677-85

Ginsberg, B H; Cohen, R M; Kahn, C R; Roth, J (1978. ) Properties and partial purification of the detergent-solubilized insulin receptor: a demonstration of negative cooperativity in micellar solution. Biochimica et biophysica acta, , 542 (1 ) ,88-100

Rosenfield, R L; Cohen, R M; Talerman, A (1987. ) Lipid cell tumor of the ovary in reference to adult-onset congenital adrenal hyperplasia and polycystic ovary syndrome. A case report. The Journal of reproductive medicine, , 32 (5 ) ,363-9

Revers, R R; Henry, R; Schmeiser, L; Kolterman, O; Cohen, R; Bergenstal, R; Polonsky, K; Jaspan, J; Rubenstein, A; Frank, B (1984. ) The effects of biosynthetic human proinsulin on carbohydrate metabolism. Diabetes, , 33 (8 ) ,762-70

Revers, R R; Henry, R; Schmeiser, L; Kolterman, O; Cohen, R; Rubenstein, A; Frank, B; Galloway, J; Olefsky, J M (1984. ) Biosynthetic human insulin and proinsulin have additive but not synergistic effects on total body glucose disposal. The Journal of clinical endocrinology and metabolism, , 58 (6 ) ,1094-8

Rymaszewski, Z; Abplanalp, W A; Cohen, R M; Chomczynski, P (1990. ) Estimation of cellular DNA content in cell lysates suitable for RNA isolation. Analytical biochemistry, , 188 (1 ) ,91-6

Tam, E S; Ferguson, D G; Bielefeld, D R; Lorenz, J N; Cohen, R M; Pun, R Y (1997. ) Norepinephrine-mediated calcium signaling is altered in vascular smooth muscle of diabetic rat. Cell calcium, , 21 (2 ) ,143-50

Pinhas-Hamiel, O; Standiford, D; Hamiel, D; Dolan, L M; Cohen, R; Zeitler, P S (1999. ) The type 2 family: a setting for development and treatment of adolescent type 2 diabetes mellitus. Archives of pediatrics & adolescent medicine, , 153 (10 ) ,1063-7

Leslie, R David G; Cohen, Robert M (2009. ) Biologic variability in plasma glucose, hemoglobin A1c, and advanced glycation end products associated with diabetes complications. Journal of diabetes science and technology, , 3 (4 ) ,635-43

Barzilay, Joshua I; Howard, Annie G; Evans, Gregory W; Fleg, Jerome L; Cohen, Robert M; Booth, Gillian L; Kimel, Angela R; Pedley, Carolyn F; Cushman, William C (2012. ) Intensive Blood Pressure Treatment Does Not Improve Cardiovascular Outcomes in Centrally Obese Hypertensive Individuals With Diabetes: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) Blood Pressure Trial.Diabetes Care, , 35 (7 ) ,1401-5

Joshua I. Barzilay , Annie G. Howard, Gregory W. Evans, Jerome L. Fleg, Robert M. Cohen, Gillian L. Booth, MD, Angela R. Kimel, Carolyn F. Pedley, William C. Cushman (2012. ) Intensive Blood Pressure Treatment Does Not Improve Cardiovascular Outcomes in Centrally Obese Hypertensive Individuals With Diabetes: The Action to Control Cardiovascular Risk in Diabetes . Diabetes Care , , (35 ) ,1401-1405

Cohen RM and Lindsell CJ (2012. ) When the Blood Glucoses and the A1c Don’t Match: Turning Uncertainty into Opportunity. Diabetes Care , , (35 ) ,2421-2423

Robert S. Franco, M. Estela Campanella, Latorya A. Barber, Mary B. Palascak, Clinton H. Joiner, Philip S. Low, and Robert M. Cohen. (2012. ) Changes in the Properties of Normal Human Red Blood Cells during In Vivo Aging. American J Hematology, , (88 ) ,44-51

Robert S. Franco, M. Estela Campanella, Latorya A. Barber, Mary B. Palascak, Clinton H. Joiner, Philip S. Low, and Robert M. Cohen. (2012. ) Changes in the Properties of Normal Human Red Blood Cells during In Vivo Aging. American J Hematology, , (88 ) ,44-51

Cohen RM and Sacks DB (2012. ) Comparing Multiple Measures of Glycemia: How to Transitionfrom Biomarker to Diagnostic Test . Clinical Chemistry, , (58 ) ,1615-1617

Fonseca V, McDuffie R, Calles J, Cohen RM, Feeney P, Feinglos M, Gerstein H, Ismail Beigi F, Morgan TM, Pop-Busui R, Riddle Matthew C and the ACCORD study group. (2013. ) Determinants of Weight Gain in the ACCORD Trial .Diabetes Care, , (36 ) ,2162-2168

Cohen RM and Herman WH (2014. ) Are glycated serum proteins ready for prime time? .The Lancet Diabetes & Endocrinology (Invited Commentary), , 2 (4 ) ,264 -265

Karen L. Margolis, Patrick J. O’Connor, Timothy M. Morgan, John Buse, Robert Cohen, William C. Cushman, Jeffrey A. Cutler, Greg Evans, Hertzel Gerstein, Richard H. Grimm Jr, Edward Lipkin, K.M. Venkat Narayan, Matthew C. Riddle, Denise Simons-Morton, Ajay Sood, David C. Goff Jr. (2014. ) Outcomes of Combined Cardiovascular Risk Factor Management Strategies in Type 2 Diabetes Mellitus: The ACCORD Trial . Diabetes Care , ,

Paramjit K. Khera, Eric P. Smith, Christopher J. Lindsell, M. Colleen Rogge, Shannon Haggerty, David A. Wagner, Mary B. Palascak, Shilpa Mehta, Jacqueline M. Hibbert, Clinton H. Joiner, Robert S. Franco, Robert M. Cohen (2014. ) An oral stable isotope label confirms red blood cell mean age varies among individuals and influences HbA1c interpretation .

Mock DM, Widness JA, Veng-Pedersen P, Strauss RG, Cancelas JA, Cohen RM, Lindsell CJ, Franco RS. (2014. ) Measurement of Post-Transfusion Red Cell Survival with the Biotin Label .Transfusion Reviews, ,

Vasilios Papademetriou, Laura Lovato, Michael Doumas, Eric Nylen, Amy Mottl, Robert M Cohen, Bill Applegate, Zubin Puntakee, Gillian Booth, Jean Francois Yale, William Cushman; for the ACCORD Study Group (2014. ) The impact of chronic kidney disease and intensive glycemic control on cardiovascular outcomes in patients with type 2 diabetes.

Cohen, Robert M; Herman, William H (2014. ) Are glycated serum proteins ready for prime time?.The lancet. Diabetes & endocrinology, , 2 (4 ) ,264-5

Cohen, Robert M; Lindsell, Christopher J (2012. ) When the blood glucose and the HbA(1c) don't match: turning uncertainty into opportunity.Diabetes care, , 35 (12 ) ,2421-3

Bernstein, D I; Creticos, P S; Busse, W W; Cohen, R; Graft, D F; Howland, W C; Lumry, W R; Pedinoff, A J; Ratner, P H; Lim, J; Stokes, A; McNally, C (1996. ) Comparison of triamcinolone acetonide nasal inhaler with astemizole in the treatment of ragweed-induced allergic rhinitis. The Journal of allergy and clinical immunology, , 97 (3 ) ,749-55

Mock, Donald M; Widness, John A; Veng-Pedersen, Peter; Strauss, Ronald G; Cancelas, Jose A; Cohen, Robert M; Lindsell, Christopher J; Franco, Robert S (2014. ) Measurement of Posttransfusion Red Cell Survival With the Biotin Label.Transfusion medicine reviews, , 28 (3 ) ,114-125

Margolis, Karen L; O'Connor, Patrick J; Morgan, Timothy M; Buse, John B; Cohen, Robert M; Cushman, William C; Cutler, Jeffrey A; Evans, Gregory W; Gerstein, Hertzel C; Grimm, Richard H; Lipkin, Edward W; Narayan, K M Venkat; Riddle, Matthew C; Sood, Ajay; Goff, David C (2014. ) Outcomes of combined cardiovascular risk factor management strategies in type 2 diabetes: the ACCORD randomized trial.Diabetes care, , 37 (6 ) ,1721-8

Smith, Eric P; Cohen, Robert M (2015. ) Physiologic Concepts That May Revise the Interpretation and Implications of HbA1C in Clinical Medicine: An American Perspective.Journal of diabetes science and technology, , 9 (3 ) ,696-700

Papademetriou, Vasilios; Lovato, Laura; Doumas, Michael; Nylen, Eric; Mottl, Amy; Cohen, Robert M; Applegate, William B; Puntakee, Zubin; Yale, Jean Francois; Cushman, William C (2015. ) Chronic kidney disease and intensive glycemic control increase cardiovascular risk in patients with type 2 diabetes.Kidney international, , 87 (3 ) ,649-59

Lewis, Julia B; Sika, Mohammed; Koury, Mark J; Chuang, Peale; Schulman, Gerald; Smith, Mark T; Whittier, Frederick C; Linfert, Douglas R; Galphin, Claude M; Athreya, Balaji P; Nossuli, A Kaldun Kaldun; Chang, Ingrid J; Blumenthal, Samuel S; Manley, John; Zeig, Steven; Kant, Kotagal S; Olivero, Juan Jose; Greene, Tom; Dwyer, Jamie P (2015. ) Ferric citrate controls phosphorus and delivers iron in patients on dialysis.Journal of the American Society of Nephrology : JASN, , 26 (2 ) ,493-503

Khera, Paramjit K; Smith, Eric P; Lindsell, Christopher J; Rogge, Mary Colleen; Haggerty, Shannon; Wagner, David A; Palascak, Mary B; Mehta, Shilpa; Hibbert, Jacqueline M; Joiner, Clinton H; Franco, Robert S; Cohen, Robert M (2015. ) Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation.American journal of hematology, , 90 (1 ) ,50-5

Schwartz, Ann V; Chen, Haiying; Ambrosius, Walter T; Sood, Ajay; Josse, Robert G; Bonds, Denise E; Schnall, Adrian M; Vittinghoff, Eric; Bauer, Douglas C; Banerji, Mary Ann; Cohen, Robert M; Hamilton, Bruce P; Isakova, Tamara; Sellmeyer, Deborah E; Simmons, Debra L; Shibli-Rahhal, Amal; Williamson, Jeff D; Margolis, Karen L (2015. ) Effects of TZD Use and Discontinuation on Fracture Rates in ACCORD Bone Study.The Journal of clinical endocrinology and metabolism, , 100 (11 ) ,4059-66

Inge, Thomas H; Prigeon, Ronald L; Elder, Deborah A; Jenkins, Todd M; Cohen, Robert M; Xanthakos, Stavra A; Benoit, Stephen C; Dolan, Lawrence M; Daniels, Stephen R; D'Alessio, David A (2015. ) Insulin Sensitivity and ?-Cell Function Improve after Gastric Bypass in Severely Obese Adolescents.The Journal of pediatrics, , 167 (5 ) ,1042-1048.e1

Drake, T C; Hsu, F-C; Hire, D; Chen, S-H; Cohen, R M; McDuffie, R; Nylen, E; O'Connor, P; Rehman, S; Seaquist, E R (2015. ) Factors associated with failure to achieve a glycated haemoglobin target of <8.0% in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.Diabetes, obesity & metabolism, ,

Quinn, Charles T; Smith, Eric P; Arbabi, Shahriar; Khera, Paramjit K; Lindsell, Christopher J; Niss, Omar; Joiner, Clinton H; Franco, Robert S; Cohen, Robert M (2016. ) Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia.American journal of hematology, , 91 (12 ) ,1195-1201

Cohen, Robert M; Franco, Robert S (2016. ) Can Red Blood Cell Indices Act as Surrogate Markers for Discordance between Hemoglobin A1c and Fasting Blood Glucose?.Clinical chemistry, , 62 (12 ) ,1551-1553

Cohen, Robert M; Smith, Eric P; Arbabi, Shahriar; Quinn, Charles T; Franco, Robert S (2016. ) Do Red Blood Cell Indices Explain Racial Differences in the Relationship between Hemoglobin A1c and Blood Glucose?.The Journal of pediatrics, , 176 ,7-9

Freedman, Barry I; Sink, Kaycee M; Hugenschmidt, Christina E; Hughes, Timothy M; Williamson, Jeff D; Whitlow, Christopher T; Palmer, Nicholette D; Miller, Michael E; Lovato, Laura C; Xu, Jianzhao; Smith, S Carrie; Launer, Lenore J; Barzilay, Joshua I; Cohen, Robert M; Sullivan, Mark D; Bryan, R Nick; Wagner, Benjamin C; Bowden, Donald W; Maldjian, Joseph A; Divers, Jasmin (2017. ) Associations of Early Kidney Disease With Brain Magnetic Resonance Imaging and Cognitive Function in African Americans With Type 2 Diabetes Mellitus.American journal of kidney diseases : the official journal of the National Kidney Foundation, ,

Schmidt, Robert L; Mock, Donald M; Franco, Robert S; Cohen, Robert M; North, Anne K; Cancelas, José A; Geisen, Christof; Strauss, Ronald G; Vlaar, Alexander P; Nalbant, Demet; Widness, John A (2017. ) Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.Transfusion, , 57 (6 ) ,1488-1496

Angellotti, Edith; D'Alessio, David; Dawson-Hughes, Bess; Nelson, Jason; Cohen, Robert M; Gastaldelli, Amalia; Pittas, Anastassios G (2018. ) Vitamin D Supplementation in Patients With Type 2 Diabetes: The Vitamin D for Established Type 2 Diabetes (DDM2) Study.Journal of the Endocrine Society, , 2 (4 ) ,310-321

Larkin, Mary E; Nathan, David M; Bebu, Ionut; Krause-Steinrauf, Heidi; Herman, William H; Higgins, John M; Tiktin, Margaret; Cohen, Robert M; Lund, Claire; Bergenstal, Richard M; Johnson, Mary L; Arends, Valerie (2019. ) Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring.Diabetes technology & therapeutics, , 21 (12 ) ,682-690

Morris, Mackenzie C; Jung, Andrew D; Kim, Young; Lee, Tiffany C; Kaiser, Tiffany E; Thompson, Jonathan R; Bari, Khurram; Shah, Shimul A; Cohen, Robert M; Schauer, Daniel P; Smith, Eric P; Diwan, Tayyab S (2019. ) Delayed Sleeve Gastrectomy Following Liver Transplantation: A 5-Year Experience.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, , 25 (11 ) ,1673-1681

Angellotti, Edith; D'Alessio, David; Dawson-Hughes, Bess; Chu, Yan; Nelson, Jason; Hu, Peter; Cohen, Robert M; Pittas, Anastassios G (2019. ) Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes.Clinical nutrition (Edinburgh, Scotland), , 38 (5 ) ,2449-2453

Klonoff, David C; Aron, David; Cohen, Robert M; Home, Philip; John, W Garry; Little, Randie R; Nathan, David M; Sacks, David B (2019. ) The Need for Accuracy in Hemoglobin A1c Proficiency Testing: Why the Proposed CLIA Rule of 2019 Is a Step Backward.Journal of diabetes science and technology, , 13 (3 ) ,424-427

Cohen, Robert M; Franco, Robert S; Smith, Eric P; Higgins, John M (2019. ) When HbA1c and Blood Glucose Do Not Match: How Much Is Determined by Race, by Genetics, by Differences in Mean Red Blood Cell Age?.The Journal of clinical endocrinology and metabolism, , 104 (3 ) ,707-710

Mather, Kieren J; Bebu, Ionut; Baker, Chelsea; Cohen, Robert M; Crandall, Jill P; DeSouza, Cyrus; Green, Jennifer B; Kirkman, M Sue; Krause-Steinrauf, Heidi; Larkin, Mary; Pettus, Jeremy; Seaquist, Elizabeth R; Soliman, Elsayed Z; Schroeder, Emily B; Wexler, Deborah J; Pop-Busui, Rodica (2020. ) Prevalence of microvascular and macrovascular disease in the Glycemia Reduction Approaches in Diabetes - A Comparative Effectiveness (GRADE) Study cohort.Diabetes research and clinical practice, , 165 ,108235

Bari, Khurram; Shah, Shimul A; Kaiser, Tiffany E; Cohen, Robert M; Anwar, Nadeem; Kleesattel, David; Sherman, Kenneth E (2020. ) Safety and Efficacy of Budesonide for Liver Transplant Immune Suppression: Results of a Pilot Phase 2a Trial.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, ,

Sivitz, William I; Phillips, Lawrence S; Wexler, Deborah J; Fortmann, Stephen P; Camp, Anne W; Tiktin, Margaret; Perez, Magalys; Craig, Jacqueline; Hollander, Priscilla A; Cherrington, Andrea; Aroda, Vanita R; Tan, Meng Hee; Krakoff, Jonathan; Rasouli, Neda; Butera, Nicole M; Younes, Naji (2020. ) Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight.Diabetes care, , 43 (5 ) ,940-947

Rasouli, Neda; Younes, Naji; Utzschneider, Kristina M; Inzucchi, Silvio E; Balasubramanyam, Ashok; Cherrington, Andrea L; Ismail-Beigi, Faramarz; Cohen, Robert M; Olson, Darin E; DeFronzo, Ralph A; Herman, William H; Lachin, John M; Kahn, Steven E (2020. ) Association of Baseline Characteristics With Insulin Sensitivity and ?-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort.Diabetes care, ,

Honors and Awards

2006 Southwest Ohio and Northern Kentucky American Diabetes Association "Brushes with Greatness" Award

1999 Listed in "Guide to Top Doctors," published by the Center for the Study of Services (www.checkbook.org)

1973 -1974 Amherst College - Independent Scholar in Biochemistry

1973 Amherst College - James R. Elster Award

Post Graduate Training and Education

1981-1984 Fellow, Section of Endocrinology, Department of Medicine, University of Chicago, , Chicago, IL

1978-1981 Intern and Resident, Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, , Chicago, IL

Keywords

Endocrine Diseases,Diabetes Mellitus,Glucose Intolerance,Nutritional and Metabolic Diseases,Hyperinsulinemia,Hypoglycemia,Endocrine Gland Neoplasms,Hormones,Endocrine Linkage (Genetics),Drug Interactions,Carbohydrates and Hypoglycemic Agents,Health Planning,Non-Insulin-Dependent,Drug Down-Regulation (Physiology)

Contact Information

Academic - Medical Sciences Building
231 Albert Sabin Way, ML 0547
Cincinnati  Ohio, 45267-0547
Phone: 513-558-4444
Fax: 513-558-8581