Margaret Collins

Margaret S. Collins

Sr Research Associate

Childrens Hospital Bldg R

R4029

COM IM Pulmonary Division - 0585

Research Support

Grant: #R01 AI076104 Investigators:Collins, Margaret; Cushion, Melanie 02-01-2008 -01-31-2013 National Institute of Allergy and Infectious Diseases Biofilm Formation by Pneumocystis Role:Collaborator $1,500,341.00 Closed Level:Federal

Grant: #VA Intergovernmental Personnel Act Agreement - Margaret S Collins Investigators:Collins, Margaret 01-01-2012 -12-31-2013 Department of Veterans Affairs Intergovernmental Personnel Act Agreement - Margaret S Collins Role:PI $64,194.00 Active Level:Federal

Publications

Peer Reviewed Publications

Cushion, Melanie T; Collins, Margaret S; Sesterhenn, Thomas; Porollo, Aleksey; Vadukoot, Anish Kizhakkekkara; Merino, Edward J (2016. ) Functional Characterization of Pneumocystis carinii Inositol Transporter 1.mBio, , 7 (6 ) ,

Porollo, Aleksey; Sesterhenn, Thomas M; Collins, Margaret S; Welge, Jeffrey A; Cushion, Melanie T (2014. ) Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism.mBio, , 5 (6 ) ,e01834

Linke, Michael J; Ashbaugh, Alan; Collins, Margaret S; Lynch, Keeley; Cushion, Melanie T (2013. ) Characterization of a distinct host response profile to Pneumocystis murina asci during clearance of pneumocystis pneumonia.Infection and immunity, , 81 (3 ) ,984-95

Maciejewska, Dorota; Zabinski, Jerzy; Ka?mierczak, Pawel; Rezler, Mateusz; Krassowska-?wiebocka, Barbara; Collins, Margaret S; Cushion, Melanie T (2012. ) Analogs of pentamidine as potential anti-Pneumocystis chemotherapeutics.European journal of medicinal chemistry, , 48 ,164-73

Cushion, Melanie T; Collins, Margaret S (2011. ) Susceptibility of Pneumocystis to echinocandins in suspension and biofilm cultures.Antimicrobial agents and chemotherapy, , 55 (10 ) ,4513-8

Cushion, Melanie T; Linke, Michael J; Ashbaugh, Alan; Sesterhenn, Tom; Collins, Margaret S; Lynch, Keeley; Brubaker, Ronald; Walzer, Peter D (2010. ) Echinocandin treatment of pneumocystis pneumonia in rodent models depletes cysts leaving trophic burdens that cannot transmit the infection.PloS one, , 5 (1 ) ,e8524

Joffrion, Tiffany M; Collins, Margaret S; Sesterhenn, Thomas; Cushion, Melanie T (2010. ) Functional characterization and localization of Pneumocystis carinii lanosterol synthase.Eukaryotic cell, , 9 (1 ) ,107-15

Vale, Nuno; Prudêncio, Miguel; Marques, Catarina A; Collins, Margaret S; Gut, Jiri; Nogueira, Fátima; Matos, Joana; Rosenthal, Philip J; Cushion, Melanie T; do Rosário, Virgílio E; Mota, Maria M; Moreira, Rui; Gomes, Paula (2009. ) Imidazoquines as antimalarial and antipneumocystis agents.Journal of medicinal chemistry, , 52 (23 ) ,7800-7

Huang, Tien L; Vanden Eynde, Jean Jacques; Mayence, Annie; Collins, Margaret S; Cushion, Melanie T; Rattendi, Donna; Londono, Indira; Mazumder, Lakshman; Bacchi, Cyrus J; Yarlett, Nigel (2009. ) Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.Bioorganic & medicinal chemistry letters, , 19 (20 ) ,5884-6

Cushion, Melanie T; Collins, Margaret S; Linke, Michael J (2009. ) Biofilm formation by Pneumocystis spp.Eukaryotic cell, , 8 (2 ) ,197-206

Mayence, Annie; Pietka, Aurélie; Collins, Margaret S; Cushion, Melanie T; Tekwani, Babu L; Huang, Tien L; Vanden Eynde, Jean Jacques (2008. ) Novel bisbenzimidazoles with antileishmanial effectiveness.Bioorganic & medicinal chemistry letters, , 18 (8 ) ,2658-61

Vale, Nuno; Collins, Margaret S; Gut, Jiri; Ferraz, Ricardo; Rosenthal, Philip J; Cushion, Melanie T; Moreira, Rui; Gomes, Paula (2008. ) Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones.Bioorganic & medicinal chemistry letters, , 18 (2 ) ,485-8

Joffrion, Tiffany M; Collins, Margaret S; Cushion, Melanie T (2006. ) Microaerophilic conditions increase viability and affect responses of Pneumocystis carinii to drugs in vitro.The Journal of eukaryotic microbiology, , 53 Suppl 1 ,S117-8

Cushion, Melanie T; Walzer, Peter D; Collins, Margaret S; Rebholz, Sandra; Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L (2004. ) Highly active anti-Pneumocystis carinii compounds in a library of novel piperazine-linked bisbenzamidines and related compounds.Antimicrobial agents and chemotherapy, , 48 (11 ) ,4209-16

Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L; Collins, Margaret S; Rebholz, Sandra; Walzer, Peter D; Cushion, Melanie T (2004. ) Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.Bioorganic & medicinal chemistry letters, , 14 (17 ) ,4545-8

Collins, Margaret S; Bansil, Sandeep; Cushion, Melanie T (2003. ) Expression profiling of the responses of Pneumocystis carinii to drug treatment using DNA macroarrays. The Journal of eukaryotic microbiology, , 50 Suppl ,605-6

Zhou, Wenxu; Nguyen, Thi Thuy Minh; Collins, Margaret S; Cushion, Melanie T; Nes, W David (2002. ) Evidence for multiple sterol methyl transferase pathways in Pneumocystis carinii. Lipids, , 37 (12 ) ,1177-86

Icenhour, Crystal R; Rebholz, Sandra L; Collins, Margaret S; Cushion, Melanie T (2002. ) Early acquisition of Pneumocystis carinii in neonatal rats as evidenced by PCR and oral swabs. Eukaryotic cell, , 1 (3 ) ,414-9

Icenhour, C R; Rebholz, S L; Collins, M S; Cushion, M T (2001. ) Widespread occurrence of Pneumocystis carinii in commercial rat colonies detected using targeted PCR and oral swabs.Journal of clinical microbiology, , 39 (10 ) ,3437-41

Collins, M S; Cushion, M T (2001. ) Standardization of an in vitro drug screening assay by use of cryopreserved and characterized Pneumocystis carinii populations. The Journal of eukaryotic microbiology, , Suppl ,178S-179S

Icenhour, C R; Rebholz, S L; Collins, M S; Cushion, M T (2001. ) Early acquisition of Pneumocystis carinii in neonatal rats using targeted PCR and oral swabs. The Journal of eukaryotic microbiology, , Suppl ,135S-136S

Kaneshiro, E S; Collins, M S; Cushion, M T (2000. ) Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii. Antimicrobial agents and chemotherapy, , 44 (6 ) ,1630-8