Keith A Crutcher

Volunteer Professor

Medical Sciences Building

COM Neurosurgery - 0515

Research and Practice Interests

Crutcher Lab Research Program: The research program is focused on two major areas. The first is the study of themechanisms underlying axonal sprouting and abortive regeneration in the mature mammalian brain. The primary model involves studies of axonal sprouting in the CNS or on sections of the CNS. Some of the findings that have emerged from this research programinclude: the demonstration of nerve growth factor (NGF) in the mammalian CNS, increased NGF in the hippocampus following septal denervation, induction of perivascular sympathetic sprouting in response to intraventricular infusion of NGF, CNS white matter inhibition of neurite outgrowth in culture, penetration of the hippocampal neuropil by sympathetic fibers, age-related decreases in target receptivity to sprouting, geometric constraints on axonal regeneration, and the hypothesis of trophomorphism. Current research, funded through the NIH, is focused on identifying the role that NGF plays in regulation of axonal growth in CNS white matter. The second research area involves studies of the role of apolipoprotein E in Alzheimer's disease. This program is funded through a grant from the NIH and focuses on the hypothesis that apoE exhibits isoform-specific neurotoxic effects that may be mediated through proteolytic fragments. Current work involves studies of human brain tissue and transgenic apoE mice.

Research Support

Grant: #R01-AG-20249-04 Investigators:Crutcher, Keith 09-30-2002 -08-31-2009 National Institute on Aging Proteoloysis pof apoE and Alzheimer's Pathology Role:PI $1,946,413.20 Closed Level:Federal

Grant: #n/a Investigators:Crutcher, Keith 04-24-2003 -06-15-2009 Fidelity Foundation Studies of the role of ApoE Proteolysis in Alzheimer's Pathogenesis Role:PI $100,000.00 Closed Level:Private Non-Profit

Grant: #5-R01-NS-044972-04-A1-S0-E0 Investigators:Crutcher, Keith 12-01-2002 -11-30-2006 National Institute of Neurological Disorders and Stroke NGF Effects in Axonal Growth in CNS White Matter Role:PI $1,159,746.00 Closed Level:Federal

Grant: #5-R01-NS-17131-15-A0-S0-E0 Investigators:Crutcher, Keith 09-01-1994 -08-31-1999 National Institute of Neurological Disorders and Stroke Axonal Growth in the Mature Mammalian CNS Role:PI $614,233.00 Closed Level:Federal

Grant: #RG1-96-043-03-A0-S0-E0 Investigators:Crutcher, Keith 01-01-1997 -12-31-1999 Alzheimer's Association Neurotoxic ApoE Peptides in Alzheimer's Disease Role:PI $144,979.00 Closed Level:Private Non-Profit

Keywords

Anatomy(MeSH A),Organisms(MeSH B),Diseases(MeSH C),Chemicals and Drugs(MeSH D),Analytical, Diagnostic and Therapeutic Techniques and Equipment(MeSH E),Biological Sciences(MeSH G),Information Science(MeSH L),Nervous System(MeSH A08),Tissues(MeSH A10),Cells(MeSH A11),Vertebrates(MeSH B02),Nervous System Diseases(MeSH C10),Enzymes, Coenzymes, and Enzyme Inhibitors(MeSH D08),Growth Substances, Pigments, and Vitamins(MeSH D11),Central Nervous System Agents(MeSH D15),Investigative Techniques(MeSH E05),Biological Phenomena, Cell Phenomena, and Immunity(MeSH G04)