W. Davidson

W. Sean Davidson , Ph.D.

Professor

Vice Chair - Research

Professional Summary

In human beings, the blood levels of high-density lipoprotein (HDL) are inversely correlated with the risk of cardiovascular diseases.  In general, the higher your HDL (or “good” cholesterol) level, the lower your risk for heart disease later in life.  These diseases are currently the #1 killer in this country, claiming nearly 1 million lives per year (about one person dead every 32 seconds).  In addition, these diseases are becoming increasingly prevalent in developing countries as they consume higher fat diets common to Western lifestyles.

 A major cause of cardiovascular disease is the accumulation of cholesterol in the blood vessels such as those that supply oxygen to the heart or brain.  Unresolved cycles of inflammatory response result in the accumulation of fatty plaques in the artery wall - a condition called atherosclerosis.  These plaques can constrict blood flow through the artery or even rupture to produce a blood clot or thrombus. If this happens in the coronary arteries supplying the heart, one has a heart attack.  In the brain, this can cause a stroke.  Although we know that HDL levels are inversely related to atherosclerosis, the detailed mechanisms for its protective role are not well understood

The mission of my laboratory is to determine the molecular basis underlying the protective effect of high density lipoproteins (HDL) against inflammation and atherosclerosis.  We use a wide range of techniques spanning biophysical chemistry, molecular biology, and cell biology to understand: 1) the structural organization of the major HDL apolipoproteins and their transitions in response to lipid, 2) the molecular details of HDL interactions with cell surface receptors and transporters, 3) the protein and lipid compositions of HDL subspecies and their plasma distribution in the settings of cardiovascular disease, obesity and diabetes, and 4) the specific functions of the many HDL proteins and how they interact on the particle.

The overarching goal is to use this understanding to design new therapies aimed at enhancing the protective effects of HDL against human disease.

Education

B.S.: Indiana University Bloomington, Indiana, 1990 (Biochemistry, Minor in Biology)

Doctorate: Medical College of Pennsylvania (now Drexel University) Philadelphia, Pennsylvania, 1994 (BioChemistry, "High density lipoprotein composition and cellular cholesterol efflux")

Post Doctoral Fellowship: University of Illinois Urbana, Illinois, 1997 (The domain structure of apolipoprotein A-1)

Research and Practice Interests

The mission of my laboratory is to determine the molecular basis underlying the protective effect of high density lipoproteins (HDL) against inflammation and atherosclerosis.  We use a wide range of techniques spanning biophysical chemistry, molecular biology, and cell biology to understand: 1) the structural organization of the major HDL apolipoproteins and their transitions in response to lipid, 2) the molecular details of HDL interactions with cell surface receptors and transporters, 3) the protein and lipid compositions of HDL subspecies and their plasma distribution in the settings of cardiovascular disease, obesity and diabetes, and 4) the specific functions of the many HDL proteins and how they interact on the particle.

Positions and Work Experience

05-1989 -08-1989 Undergraduate Intern, Marion Merrell-Dow Research Institute, Cincinnati, OH 45215

04-1998 -09-2003 Assistant Professor, University of Cincinnati, Cincinnati, OH 45267

09-2003 -09-2006 Associate Professor (Tenured), University of Cincinnati, Cincinnati, OH 45267

09-2006 -To Present Professor, University of Cincinnati, Department of Pathology, Cincinnati, OH 45267

01-2008 -To Present Director, Center for Lipid and Arteriosclerosis Science, Cincinnati, OH 45267

Research Support

Grant: #R01 HL082734 Investigators:Davidson, William 07-01-2006 -06-30-2011 National Heart, Lung and Blood Institute The Roles of Apolipoprotein A-IV Structure and Lipid Affinity in its Function Role:PI $1,201,291.00 Closed Level:Federal

Grant: #SRS 1190 Investigators:Davidson, William 10-01-2005 -09-30-2009 Pfizer, Inc. The Role of Ceramide in ABCA1-Mediated Cholesterol Efflux Role:PI $220,000.00 Closed Level:Industry

Grant: #R01-HL-062542 Investigators:Davidson, William 04-01-2004 -03-31-2010 National Heart, Lung and Blood Institute Apolipoprotein-Mediated Cholesterol Efflux Role:PI $1,297,045.00 Closed Level:Federal

Grant: #2003 Pfizer HDL-02-A0-S0-E0 Investigators:Davidson, William 10-01-2003 -09-30-2006 Pfizer, Inc. The Effect of Ceramide on ABCAI-mediated Lipid Efflux Role:PI $310,000.00 Closed Level:Industry

Grant: #AHA0140082N-02-A0-S0-E0 Investigators:Davidson, William 01-01-2001 -07-31-2002 American Heart Association - National Chapter The Conformation of Apolipoprotein A-I in Reconstituted High Density Lipoproteins Role:PI $150,000.00 Closed Level:Private Non-Profit

Grant: #5-R01-HL-67093-04-A0-S0-E0 Investigators:Davidson, William 08-01-2002 -07-31-2006 National Heart, Lung and Blood Institute Apolipoprotein A-1 Structure in High Density Lipoprotein Role:PI $1,049,510.00 Closed Level:Federal

Grant: #5-R01-HL-62542-05-A0-S0-E0 Investigators:Davidson, William 04-01-1999 -03-31-2004 National Heart, Lung and Blood Institute Apolipoprotein-Mediated Cholesterol Efflux Role:PI $1,083,911.00 Closed Level:Federal

Grant: #0715386B Investigators:Davidson, William; Tubb, Matthew Robert 07-01-2007 -06-30-2009 American Heart Association - Great Rivers Affiliate The Structure and Function of Apolipoprotein A-IV Role:Collaborator $21,000.00 Closed Level:Private Non-Profit

Grant: #R01 HL067093 Investigators:Davidson, William 08-01-2007 -05-31-2013 National Heart, Lung and Blood Institute Apolipoprotein A-I Structure in High Density Lipoproteins Role:PI $1,738,183.00 Closed Level:Federal

Grant: #R56 HD034089 Investigators:Davidson, William; Hui, David; Tso, Patrick P.W.; Woollett, Laura 09-01-2008 -08-31-2010 National Institute of Child Health and Human Development Sterol Metabolism During Pregnancy and Development Role:Collaborator $298,350.00 Closed Level:Federal

Grant: #20497-20 / U24 DK076169 Investigators:Davidson, William 10-01-2008 -09-30-2010 National Inst of Diabetes and Digestive and Kidney Disease Proteomic Analysis of Mouse Plasma Lipoproteins Role:PI $60,000.00 Closed Level:Federal

Grant: #SRS006853 Investigators:Davidson, William 04-26-2010 -06-30-2012 F. Hoffmann-La Roche Ltd The Effect of CETP Inhibitors on CETP Conformation Determined by Spectroscopy and Chemical Cross-Linking Role:PI $150,221.00 Closed Level:Foreign Industry

Grant: #R21 HL104136 Investigators:Davidson, William 08-15-2010 -06-30-2013 National Heart, Lung and Blood Institute The Molecular Basis for High Density Lipoprotein Heterogeneity Role:PI $439,765.00 Active Level:Federal

Grant: #R01 DK092138 Investigators:Davidson, William; Jaeschke, Anja; Ji, Yong; Tso, Patrick P.W.; Welge, Jeffrey 07-01-2011 -05-31-2015 National Inst of Diabetes and Digestive and Kidney Disease Gut Mucosal Mast Cells are Activated by Fat Absorption: Physiology and Mechanism Role:Collaborator $1,063,499.00 Active Level:Federal

Grant: #11PRE7210019 Investigators:Davidson, William; Gordon, Scott 07-01-2011 -06-30-2013 American Heart Association - Great Rivers Affiliate Proteomic and Functional Characterization of Human High Density Lipoprotein Subspecies Role:Collaborator $46,000.00 Closed Level:Private Non-Profit

Grant: #R01 GM098458 Investigators:Davidson, William; Thompson, Thomas 09-01-2011 -06-30-2015 National Institute of General Medical Sciences A High Resolution Structural Approach to Understanding HDL Biogenesis Role:PI $884,460.00 Active Level:Federal

Grant: #U24 DK059630 Investigators:Benoit, Stephen; Dalessio, David; Davidson, William; Howles, Philip; Hui, David; Jandacek, Ronald; Obici, Silvana; Schultz, Jo El; Seeley, Randy; Tschoep, Matthias; Tso, Patrick P.W.; Welge, Jeffrey; Woods, Stephen; Woollett, Laura 09-16-2011 -06-30-2016 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:Collaborator $1,619,789.00 Active Level:Federal

Grant: #131302 \ R01HL111829 Investigators:Davidson, William; Silva, Ranasinghe; Weintraub, Neal 08-01-2012 -06-30-2013 National Heart, Lung and Blood Institute A Network-based Approach to Associate HDL Subspeciation with Function Role:PI $38,669.00 Active Level:Federal

Grant: #R01 HL067093 Investigators:Davidson, William; Silva, Ranasinghe; Woollett, Laura 07-05-2013 -05-31-2017 National Heart, Lung and Blood Institute Apolipoprotein Structure in High Density Lipoprotein Role:PI $379,931.00 Active Level:Federal

Grant: #OPP1110668 Investigators:Davidson, William; Welge, Jeffrey; Woollett, Laura 11-04-2014 -09-30-2016 Bill & Melinda Gates Foundation Improving Fetal Growth Rates in Developing Countries Role:Collaborator $439,282.00 Active Level:Private Non-Profit

Grant: #111153-2085668 / R01 HL123917 Investigators:Davidson, William 08-25-2014 -05-31-2019 National Heart, Lung and Blood Institute HDL Proteins and Coronary Heart Disease Role:PI $99,813.00 Awarded Level:Federal

Grant: #15PRE25220021 Investigators:Cooke, Allison; Davidson, William 07-01-2015 -06-30-2017 American Heart Association - Great Rivers Affiliate Apolipoprotein A-I as a docking interface for high density lipoprotein modifying proteins Role:Collaborator $26,000.00 Awarded Level:Private Non-Profit

Grant: #GRU 25034-1 sub U24DK076169 Investigators:Davidson, William 03-01-2016 -05-31-2016 National Inst of Diabetes and Digestive and Kidney Disease Rapid and Absolute Quantitation of Mouse Plasma Apolipoproteins Role:PI $75,000.00 Awarded Level:Federal

Grant: #U2CDK059630 Investigators:Benoit, Stephen; Davidson, William; Howles, Philip; Liu, Min; Reyes, Teresa; Tso, Patrick P.W.; Ulrich-Lai, Yvonne; Welge, Jeffrey; Woods, Stephen; Woollett, Laura 08-01-2016 -06-30-2021 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:Collaborator $926,069.68 Active Level:Federal

Grant: #VUMC59172 / P01HL128203 Investigators:Davidson, William; Woollett, Laura 09-15-2016 -06-30-2021 National Heart, Lung and Blood Institute Multidisciplinary Approaches to HDL Structure, Assembly, and Functional Heterogeneity Role:PI $719,150.00 Active Level:Federal

Grant: #Augusta Univ. sub U24DK076169 Investigators:Davidson, William 08-29-2016 -02-28-2017 National Inst of Diabetes and Digestive and Kidney Disease Rapid and Absolute Quantitation of Mouse Plasma Apolipoproteins Role:PI $56,506.75 Awarded Level:Federal

Grant: #R01 HL136025 Investigators:Davidson, William; Wang, Yi-Gang; Xu, Meifeng 02-06-2017 -01-31-2021 National Heart, Lung and Blood Institute Autologous Cardiomyocytes from Masseter Muscles to Repair Myocardial Infarction (MI) Role:Collaborator $449,807.00 Awarded Level:Federal

Grant: #CCHMC 138257 sub R21AI128128 Investigators:Davidson, William 12-01-2016 -11-30-2017 National Institute of Allergy and Infectious Diseases Direct interactions with HDL promote regulatory T cells survival Role:PI $56,849.90 Awarded Level:Federal

Grant: #VUMC 70514 / P01 HL128203 Investigators:Davidson, William 09-15-2018 -06-30-2019 National Heart, Lung and Blood Institute Multidisciplinary Approaches to HDL Structure, Assembly, and Functional Heterogeneity Role:PI $231,078.00 Awarded Level:Federal

Grant: #R01HL153118 Investigators:Davidson, William 07-01-2020 -06-30-2024 National Heart, Lung and Blood Institute The structural basis for cholesterol esterification in human plasma Role:PI $497,982.00 Awarded Level:Federal

Grant: #CCHMC Billing Agreement Investigators:Davidson, William; Whitacre, Brynne 07-01-2020 -05-31-2021 National Heart, Lung and Blood Institute Understanding Cardiovascular Disease Mechanisms - Billing Agreement Role:PI $36,264.00 Active Level:Federal

Grant: #R01HL155601 Investigators:Davidson, William 12-15-2020 -11-30-2024 National Heart, Lung and Blood Institute The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism Role:PI $445,974.00 Awarded Level:Federal

Grant: #R56 AI107036 Investigators:Askew, David; Davidson, William; Deepe, George 08-15-2013 -07-31-2015 National Institute of Allergy and Infectious Diseases High-density lipoprotein and A. fumigatus pathogenesis Role:Collaborator $358,728.00 Closed Level:Federal

Grant: #U2CDK059630 Investigators:Davidson, William; Liu, Min; Reyes, Teresa; Tso, Patrick; Ulrich-Lai, Yvonne 07-01-2021 -06-30-2026 National Inst of Diabetes and Digestive and Kidney Disease Cincinnati Mouse Metabolic Phenotyping Center Role:Collaborator 0.00 Hold Level:Federal

Grant: #314453/R01HL157260 Investigators:Davidson, William; Hui, David 04-01-2021 -03-31-2026 National Heart, Lung and Blood Institute Lipoprotein interactions in the entrapment of LDL in the vessel wall Role:PI 139875.00 Hold Level:Federal

Publications

Peer Reviewed Publications

Davidson, W Sean; Cooke, Allison L; Swertfeger, Debi K; Shah, Amy S (2021. ) The Difference Between High Density Lipoprotein Subfractions and Subspecies: an Evolving Model in Cardiovascular Disease and Diabetes.Current atherosclerosis reports, , 23 (6 ) ,23 More Information

Yelamanchili, Dedipya; Liu, Jing; Gotto, Antonio M; Hurley, Ayrea E; Lagor, Willam R; Gillard, Baiba K; Davidson, W Sean; Pownall, Henry J; Rosales, Corina (2020. ) Highly conserved amino acid residues in apolipoprotein A1 discordantly induce high density lipoprotein assembly in vitro and in vivo.Biochimica et biophysica acta. Molecular and cell biology of lipids, , 1865 (12 ) ,158794 More Information

Sacks, Frank M; Liang, Liang; Furtado, Jeremy D; Cai, Tianxi; Davidson, W Sean; He, Zeling; McClelland, Robyn L; Rimm, Eric B; Jensen, Majken K (2020. ) Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies.Arteriosclerosis, thrombosis, and vascular biology, , 40 (11 ) ,2714-2727 More Information

He, Yi; Ronsein, Graziella E; Tang, Chongren; Jarvik, Gail P; Davidson, W Sean; Kothari, Vishal; Song, Hyun D; Segrest, Jere P; Bornfeldt, Karin E; Heinecke, Jay W (2020. ) Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles.Circulation research, , 127 (9 ) ,1198-1210 More Information

Bedi, Shimpi; Garcia, Erwin; Jeyarajah, Elias J; Shalaurova, Irina; Perez-Matos, Maria Camila; Jiang, Z Gordon; Dullaart, Robin P F; Matyus, Steven P; Kirk, William J; Otvos, James D; Davidson, W Sean; Connelly, Margery A (2020. ) Characterization of LP-Z Lipoprotein Particles and Quantification in Subjects with Liver Disease Using a Newly Developed NMR-Based Assay.Journal of clinical medicine, , 9 (9 ) , More Information

Zhu, Qi; Weng, Jonathan; Shen, Minqian; Fish, Jace; Shen, Zhujun; Coschigano, Karen T; Davidson, W Sean; Tso, Patrick; Shi, Haifei; Lo, Chunmin C (2020. ) Apolipoprotein A-IV Enhances Fatty Acid Uptake by Adipose Tissues of Male Mice via Sympathetic Activation.Endocrinology, , 161 (4 ) , More Information

Castleberry, Mark; Davis, Xenia; Liu, Min; Thompson, Thomas B; Tso, Patrick; Davidson, W Sean (2020. ) Functional recombinant apolipoprotein A5 that is stable at high concentrations at physiological pH.Journal of lipid research, , 61 (2 ) ,244-251 More Information

May-Zhang, Linda S; Yermalitsky, Valery; Melchior, John T; Morris, Jamie; Tallman, Keri A; Borja, Mark S; Pleasent, Tiffany; Amarnath, Venkataraman; Song, Wenliang; Yancey, Patricia G; Davidson, W Sean; Linton, MacRae F; Davies, Sean S (2019. ) Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia.The Journal of biological chemistry, , 294 (50 ) ,19022-19033 More Information

Rodriguez, Annabelle; Trigatti, Bernardo L; Mineo, Chieko; Knaack, Darcy; Wilkins, John T; Sahoo, Daisy; Asztalos, Bela F; Mora, Samia; Cuchel, Marina; Pownall, Henry J; Rosales, Corina; Bernatchez, Pascal; Ribeiro Martins da Silva, Amanda; Getz, Godfrey S; Barber, Jacob L; Shearer, Gregory C; Zivkovic, Angela M; Tietge, Uwe J F; Sacks, Frank M; Connelly, Margery A; Oda, Michael N; Davidson, W Sean; Sorci-Thomas, Mary G; Vaisar, Tomas; Ruotolo, Giacomo; Vickers, Kasey C; Martel, Catherine (2019. ) Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology, , 39 (12 ) ,2457-2467 More Information

Shao, Baohai; Zelnick, Leila R; Wimberger, Jake; Himmelfarb, Jonathan; Brunzell, John; Davidson, W Sean; Snell-Bergeon, Janet K; Bornfeldt, Karin E; de Boer, Ian H; Heinecke, Jay W (2019. ) Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus.Arteriosclerosis, thrombosis, and vascular biology, , 39 (7 ) ,1483-1491 More Information

Furtado, Jeremy D; Yamamoto, Rain; Melchior, John T; Andraski, Allison B; Gamez-Guerrero, Maria; Mulcahy, Patrick; He, Zeling; Cai, Tianxi; Davidson, W Sean; Sacks, Frank M (2018. ) Distinct Proteomic Signatures in 16 HDL (High-Density Lipoprotein) Subspecies.Arteriosclerosis, thrombosis, and vascular biology, , 38 (12 ) ,2827-2842 More Information

Xu, Xiaohong Ruby; Wang, Yiming; Adili, Reheman; Ju, Lining; Spring, Christopher M; Jin, Joseph Wuxun; Yang, Hong; Neves, Miguel A D; Chen, Pingguo; Yang, Yan; Lei, Xi; Chen, Yunfeng; Gallant, Reid C; Xu, Miao; Zhang, Hailong; Song, Jina; Ke, Peifeng; Zhang, Dan; Carrim, Naadiya; Yu, Si-Yang; Zhu, Guangheng; She, Yi-Min; Cyr, Terry; Fu, Wenbin; Liu, Guoqing; Connelly, Philip W; Rand, Margaret L; Adeli, Khosrow; Freedman, John; Lee, Jeffrey E; Tso, Patrick; Marchese, Patrizia; Davidson, W Sean; Jackson, Shaun P; Zhu, Cheng; Ruggeri, Zaverio M; Ni, Heyu (2018. ) Apolipoprotein A-IV binds ?IIb?3 integrin and inhibits thrombosis.Nature communications, , 9 (1 ) ,3608 More Information

Cooke, Allison L; Morris, Jamie; Melchior, John T; Street, Scott E; Jerome, W Gray; Huang, Rong; Herr, Andrew B; Smith, Loren E; Segrest, Jere P; Remaley, Alan T; Shah, Amy S; Thompson, Thomas B; Davidson, W Sean (2018. ) A thumbwheel mechanism for APOA1 activation of LCAT activity in HDL.Journal of lipid research, , 59 (7 ) ,1244-1255 More Information

Lima, Diogo B; Melchior, John T; Morris, Jamie; Barbosa, Valmir C; Chamot-Rooke, Julia; Fioramonte, Mariana; Souza, Tatiana A C B; Fischer, Juliana S G; Gozzo, Fabio C; Carvalho, Paulo C; Davidson, W Sean (2018. ) Characterization of homodimer interfaces with cross-linking mass spectrometry and isotopically labeled proteins.Nature protocols, , 13 (3 ) ,431-458 More Information

Huang, Wei; Feng, Yuliang; Liang, Jialiang; Yu, Hao; Wang, Cheng; Wang, Boyu; Wang, Mingyang; Jiang, Lin; Meng, Wei; Cai, Wenfeng; Medvedovic, Mario; Chen, Jenny; Paul, Christian; Davidson, W Sean; Sadayappan, Sakthivel; Stambrook, Peter J; Yu, Xi-Yong; Wang, Yigang (2018. ) Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration.Nature communications, , 9 (1 ) ,700 More Information

Shen, Ling; Liu, Yin; Tso, Patrick; Wang, David Q-H; Davidson, W Sean; Woods, Stephen C; Liu, Min (2018. ) Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression.The Journal of biological chemistry, , 293 (6 ) ,2091-2101 More Information

Rebholz, Sandra L; Melchior, John T; Davidson, W Sean; Jones, Helen N; Welge, Jeffrey A; Prentice, Andrew M; Moore, Sophie E; Woollett, Laura A (2018. ) Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 32 (2 ) ,717-727 More Information

Melchior, John T; Walker, Ryan G; Cooke, Allison L; Morris, Jamie; Castleberry, Mark; Thompson, Thomas B; Jones, Martin K; Song, Hyun D; Rye, Kerry-Anne; Oda, Michael N; Sorci-Thomas, Mary G; Thomas, Michael J; Heinecke, Jay W; Mei, Xiaohu; Atkinson, David; Segrest, Jere P; Lund-Katz, Sissel; Phillips, Michael C; Davidson, W Sean (2017. ) A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state.Nature structural & molecular biology, , 24 (12 ) ,1093-1099 More Information

Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Dolan, Lawrence M; Gordon, Scott M; Otvos, James D; Melchior, John T; Elder, Deborah A; Khoury, Jane; Geh, Esmond; Shah, Amy S (2017. ) Obesity is associated with an altered HDL subspecies profile among adolescents with metabolic disease.Journal of lipid research, , 58 (9 ) ,1916-1923 More Information

Rueda, Cesar M; Rodríguez-Perea, Ana Lucia; Moreno-Fernandez, Maria; Jackson, Courtney M; Melchior, John T; Davidson, W Sean; Chougnet, Claire A (2017. ) High density lipoproteins selectively promote the survival of human regulatory T cells.Journal of lipid research, , 58 (8 ) ,1514-1523 More Information

Melchior, John T; Street, Scott E; Andraski, Allison B; Furtado, Jeremy D; Sacks, Frank M; Shute, Rebecca L; Greve, Emily I; Swertfeger, Debi K; Li, Hailong; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2017. ) Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from ABCA1.Journal of lipid research, , 58 (7 ) ,1374-1385 More Information

Swertfeger, Debi K; Li, Hailong; Rebholz, Sandra; Zhu, Xiaoting; Shah, Amy S; Davidson, W Sean; Lu, Long J (2017. ) Mapping Atheroprotective Functions and Related Proteins/Lipoproteins in Size Fractionated Human Plasma.Molecular & cellular proteomics : MCP, , 16 (4 ) ,680-693 More Information

Davidson, W S; Inge, T H; Sexmith, H; Heink, A; Elder, D; Hui, D Y; Melchior, J T; Kelesidis, T; Shah, A S (2017. ) Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function.International journal of obesity (2005), , 41 (1 ) ,83-89 More Information

Rebholz, Sandra L; Melchior, John T; Welge, Jeffrey A; Remaley, Alan T; Davidson, W Sean; Woollett, Laura A (2017. ) Effects of Multiple Freeze/Thaw Cycles on Measurements of Potential Novel Biomarkers Associated With Adverse Pregnancy Outcomes.Journal of clinical and laboratory medicine, , 2 (1 ) , More Information

Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Tso, Patrick; Reardon, Catherine A; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2016. ) Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome.Journal of proteomics, , 146 ,184-94 More Information

Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S (2016. ) Erratum. The Effects of Type 2 Diabetes on Lipoprotein Composition and Arterial Stiffness in Male Youth. Diabetes 2013;62:2958-2967.Diabetes, , 65 (7 ) ,2100 More Information

Walsh, Kyle B; Hart, Kimberly; Roll, Susan; Sperling, Matthew; Unruh, Dusten; Davidson, W Sean; Lindsell, Christopher J; Adeoye, Opeolu (2016. ) Apolipoprotein A-I and Paraoxonase-1 Are Potential Blood Biomarkers for Ischemic Stroke Diagnosis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , 25 (6 ) ,1360-5 More Information

Rosales, C; Davidson, W S; Gillard, B K; Gotto, A M; Pownall, H J (2016. ) Speciated High-Density Lipoprotein Biogenesis and Functionality.Current atherosclerosis reports, , 18 (5 ) ,25 More Information

Davidson, W Sean; Heink, Anna; Sexmith, Hannah; Melchior, John T; Gordon, Scott M; Kuklenyik, Zsuzsanna; Woollett, Laura; Barr, John R; Jones, Jeffrey I; Toth, Christopher A; Shah, Amy S (2016. ) The effects of apolipoprotein B depletion on HDL subspecies composition and function.Journal of lipid research, , 57 (4 ) ,674-86 More Information

Melchior, John T; Walker, Ryan G; Morris, Jamie; Jones, Martin K; Segrest, Jere P; Lima, Diogo B; Carvalho, Paulo C; Gozzo, Fábio C; Castleberry, Mark; Thompson, Thomas B; Davidson, W Sean (2016. ) An Evaluation of the Crystal Structure of C-terminal Truncated Apolipoprotein A-I in Solution Reveals Structural Dynamics Related to Lipid Binding.The Journal of biological chemistry, , 291 (10 ) ,5439-51 More Information

Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y (2015. ) Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis.Circulation, , 132 (20 ) ,1898-908 More Information

Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick (2015. ) Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.PloS one, , 10 (11 ) ,e0142098 More Information

Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason (2015. ) Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes.Journal of proteome research, , 14 (8 ) ,3082-94 More Information

Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S (2015. ) A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry.Journal of proteome research, , 14 (7 ) ,2943-50 More Information

Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2015. ) A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins.Journal of proteome research, , 14 (6 ) ,2686-95 More Information

Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B (2015. ) Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function.The Journal of biological chemistry, , 290 (17 ) ,10689-702 More Information

Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean (2015. ) Structure of HDL: particle subclasses and molecular components.Handbook of experimental pharmacology, , 224 ,3-51 More Information

Unruh, Dusten; Srinivasan, Ramprasad; Benson, Tyler; Haigh, Stephen; Coyle, Danielle; Batra, Neil; Keil, Ryan; Sturm, Robert; Blanco, Victor; Palascak, Mary; Franco, Robert S; Tong, Wilson; Chatterjee, Tapan; Hui, David Y; Davidson, W Sean; Aronow, Bruce J; Kalfa, Theodosia; Manka, David; Peairs, Abigail; Blomkalns, Andra; Fulton, David J; Brittain, Julia E; Weintraub, Neal L; Bogdanov, Vladimir Y (2015. ) Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis.Circulation, , 132 (20 ) ,1898-908 More Information

Correa, Katharina; Lhorente, Jean P; López, María E; Bassini, Liane; Naswa, Sudhir; Deeb, Nader; Di Genova, Alex; Maass, Alejandro; Davidson, William S; Yáñez, José M (2015. ) Genome-wide association analysis reveals loci associated with resistance against Piscirickettsia salmonis in two Atlantic salmon (Salmo salar L.) chromosomes.BMC genomics, , 16 (1 ) ,854 More Information

Lubieniecki, Krzysztof P; Lin, Song; Cabana, Emily I; Li, Jieying; Lai, Yvonne Y Y; Davidson, William S (2015. ) Genomic Instability of the Sex-Determining Locus in Atlantic Salmon (Salmo salar).G3 (Bethesda, Md.), , 5 (11 ) ,2513-22 More Information

Lubieniecki, Krzysztof P; Botwright, Natasha A; Taylor, Richard S; Evans, Brad S; Cook, Mathew T; Davidson, William S (2015. ) Expression analysis of sex-determining pathway genes during development in male and female Atlantic salmon (Salmo salar).Physiological genomics, , physiolgenomics.0001 More Information

Li, Hailong; Gordon, Scott M; Zhu, Xiaoting; Deng, Jingyuan; Swertfeger, Debi K; Davidson, W Sean; Lu, L Jason (2015. ) Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes.Journal of proteome research, , 14 (8 ) ,3082-94 More Information

Moen, Thomas; Torgersen, Jacob; Santi, Nina; Davidson, William S; Baranski, Matthew; Ødegård, Jørgen; Kjøglum, Sissel; Velle, Bente; Kent, Matthew; Lubieniecki, Krzysztof P; Isdal, Eivind; Lien, Sigbjørn (2015. ) Epithelial Cadherin Determines Resistance to Infectious Pancreatic Necrosis Virus in Atlantic Salmon.Genetics, , 200 (4 ) ,1313-26 More Information

Heink, Anna; Davidson, W Sean; Swertfeger, Debi K; Lu, L Jason; Shah, Amy S (2015. ) A Comparison of Methods To Enhance Protein Detection of Lipoproteins by Mass Spectrometry.Journal of proteome research, , 14 (7 ) ,2943-50 More Information

Gordon, Scott M; Li, Hailong; Zhu, Xiaoting; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2015. ) A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins.Journal of proteome research, , 14 (6 ) ,2686-95 More Information

Deng, Xiaodi; Walker, Ryan G; Morris, Jamie; Davidson, W Sean; Thompson, Thomas B (2015. ) Role of Conserved Proline Residues in Human Apolipoprotein A-IV Structure and Function.The Journal of biological chemistry, , 290 (17 ) ,10689-702 More Information

Kontush, Anatol; Lindahl, Mats; Lhomme, Marie; Calabresi, Laura; Chapman, M John; Davidson, W Sean (2015. ) Structure of HDL: particle subclasses and molecular components.Handbook of experimental pharmacology, , 224 ,3-51 More Information

Li, Xiaoming; Xu, Min; Wang, Fei; Ji, Yong; DavidsoN, W Sean; Li, Zongfang; Tso, Patrick (2015. ) Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.PloS one, , 10 (11 ) ,e0142098 More Information

Gutierrez, Alejandro P; Yáñez, José M; Fukui, Steve; Swift, Bruce; Davidson, William S (2015. ) Genome-wide association study (GWAS) for growth rate and age at sexual maturation in Atlantic salmon (Salmo salar).PloS one, , 10 (3 ) ,e0119730 More Information

Davidson, W Sean (2014. ) HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease.Clinical chemistry, , 60 (11 ) ,e1-3 More Information

Tessarolo, Jordan A; Tabesh, Mohammad J; Nesbitt, Michael; Davidson, William S (2014. ) Genomic organization and evolution of the trace amine-associated receptor (TAAR) repertoire in Atlantic salmon (Salmo salar).G3 (Bethesda, Md.), , 4 (6 ) ,1135-41 More Information

Walker, Ryan G; Deng, Xiaodi; Melchior, John T; Morris, Jamie; Tso, Patrick; Jones, Martin K; Segrest, Jere P; Thompson, Thomas B; Davidson, W Sean (2014. ) The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering.The Journal of biological chemistry, , 289 (9 ) ,5596-608 More Information

Lo, Chunmin C; Davidson, W Sean; Hibbard, Stephanie K; Georgievsky, Maria; Lee, Alexander; Tso, Patrick; Woods, Stephen C (2014. ) Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats.Endocrinology, , en20131846 More Information

Li, Xiaoming; Xu, Min; Wang, Fei; Kohan, Alison B; Haas, Michael K; Yang, Qing; Lou, Danwen; Obici, Silvana; Davidson, W Sean; Tso, Patrick (2014. ) Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.The Journal of biological chemistry, , 289 (4 ) ,2396-404 More Information

Davidson, W Sean (2014. ) HDL-C vs HDL-P: how changing one letter could make a difference in understanding the role of high-density lipoprotein in disease.Clinical chemistry, , 60 (11 ) ,e1-3 More Information

Davidson, W Sean (2013. ) A Tribute to the Philadelphia Lipid Group on the Occasion of Their Retirement.Journal of lipid research, , More Information

Niesor, Eric J; Gauthamadasa, Kekulawalage; Silva, R A Gangani D; Suchankova, Gabriela; Kallend, David; Gylling, Helena; Asztalos, Bela; Damonte, Elisabetta; Rossomanno, Simona; Abt, Markus; Davidson, W Sean; Benghozi, Renee (2013. ) Xanthophylls, phytosterols and pre-?1-HDL are differentially affected by fenofibrate and niacin HDL-raising in a cross-over study.Lipids, , 48 (12 ) ,1185-96 More Information

Lehti, Maarit; Donelan, Elizabeth; Abplanalp, William; Al-Massadi, Omar; Habegger, Kirk M; Weber, Jon; Ress, Chandler; Mansfeld, Johannes; Somvanshi, Sonal; Trivedi, Chitrang; Keuper, Michaela; Ograjsek, Teja; Striese, Cynthia; Cucuruz, Sebastian; Pfluger, Paul T; Krishna, Radhakrishna; Gordon, Scott M; Silva, R A Gangani D; Luquet, Serge; Castel, Julien; Martinez, Sarah; D'Alessio, David; Davidson, W Sean; Hofmann, Susanna M (2013. ) High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.Circulation, , 128 (22 ) ,2364-71 More Information

Gordon, Scott M; Deng, Jingyuan; Tomann, Alex B; Shah, Amy S; Lu, L Jason; Davidson, W Sean (2013. ) Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipoprotein subspecies.Molecular & cellular proteomics : MCP, , 12 (11 ) ,3123-34 More Information

Shah, Amy S; Tan, Lirong; Long, Jason Lu; Davidson, W Sean (2013. ) Proteomic diversity of high density lipoproteins: our emerging understanding of its importance in lipid transport and beyond.Journal of lipid research, , 54 (10 ) ,2575-85 More Information

Wang, Fei; Pearson, Kevin J; Davidson, W Sean; Tso, Patrick (2013. ) Specific sequences in N termini of apolipoprotein A-IV modulate its anorectic effect.Physiology & behavior, , 120 ,136-42 More Information

Gordon, Scott M; Davidson, W Sean; Urbina, Elaine M; Dolan, Lawrence M; Heink, Anna; Zang, Huaiyu; Lu, L Jason; Shah, Amy S (2013. ) The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth.Diabetes, , 62 (8 ) ,2958-67 More Information

Smith, Loren E; Segrest, Jere P; Davidson, W Sean (2013. ) Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II.Journal of lipid research, , 54 (7 ) ,1939-48 More Information

Nguyen, Andrew D; Nguyen, Thi A; Cenik, Basar; Yu, Gang; Herz, Joachim; Walther, Tobias C; Davidson, W Sean; Farese, Robert V (2013. ) Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).The Journal of biological chemistry, , 288 (12 ) ,8627-35 More Information

Deng, Xiaodi; Morris, Jamie; Chaton, Catherine; Schröder, Gunnar F; Davidson, W Sean; Thompson, Thomas B (2013. ) Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability.The Journal of biological chemistry, , 288 (7 ) ,4854-66 More Information

Perez-Tilve, Diego; Davidson, W Sean; Tschöp, Matthias; Hofmann, Susanna M (2012. ) CNS regulation of plasma cholesterol.Annals of medicine, , 44 (7 ) ,656-63 More Information

Smith, Loren E; Yang, Jun; Goodman, Leah; Huang, Xinqi; Huang, Rong; Dressman, James; Morris, Jamie; Silva, R A Gangani D; Davidson, W Sean; Cavigiolio, Giorgio (2012. ) High yield expression and purification of recombinant human apolipoprotein A-II in Escherichia coli.Journal of lipid research, , 53 (8 ) ,1708-15 More Information

Wang, Fei; Kohan, Alison B; Kindel, Tammy L; Corbin, Kathryn L; Nunemaker, Craig S; Obici, Silvana; Woods, Stephen C; Davidson, W Sean; Tso, Patrick (2012. ) Apolipoprotein A-IV improves glucose homeostasis by enhancing insulin secretion.Proceedings of the National Academy of Sciences of the United States of America, , 109 (24 ) ,9641-6 More Information

Deng, Xiaodi; Morris, Jamie; Dressmen, James; Tubb, Matthew R; Tso, Patrick; Jerome, W Gray; Davidson, W Sean; Thompson, Thomas B (2012. ) The structure of dimeric apolipoprotein A-IV and its mechanism of self-association.Structure (London, England : 1993), , 20 (5 ) ,767-79 More Information

Rosenson, Robert S; Brewer, H Bryan; Davidson, W Sean; Fayad, Zahi A; Fuster, Valentin; Goldstein, James; Hellerstein, Marc; Jiang, Xian-Cheng; Phillips, Michael C; Rader, Daniel J; Remaley, Alan T; Rothblat, George H; Tall, Alan R; Yvan-Charvet, Laurent (2012. ) Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport.Circulation, , 125 (15 ) ,1905-19 More Information

Gordon, Scott M; Davidson, William S (2012. ) Apolipoprotein A-I mimetics and high-density lipoprotein function.Current opinion in endocrinology, diabetes, and obesity, , 19 (2 ) ,109-14 More Information

Deng, Xiaodi; Davidson, W Sean; Thompson, Thomas B (2012. ) Improving the diffraction of apoA-IV crystals through extreme dehydration.Acta crystallographica. Section F, Structural biology and crystallization communications, , 68 (Pt 1 ) ,105-10 More Information

Huang, Rong; Silva, R A Gangani D; Jerome, W Gray; Kontush, Anatol; Chapman, M John; Curtiss, Linda K; Hodges, Timothy J; Davidson, W Sean (2011. ) Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma.Nature structural & molecular biology, , More Information

Basford, Joshua E; Wancata, Lauren; Hofmann, Susanna M; Silva, R A Gangani D; Davidson, W Sean; Howles, Philip N; Hui, David Y (2011. ) Hepatic deficiency of low density lipoprotein receptor-related protein-1 reduces high density lipoprotein secretion and plasma levels in mice.The Journal of biological chemistry, , More Information

Gordon, Scott M; Hofmann, Susanna; Askew, David S; Davidson, W Sean (2011. ) High density lipoprotein: it's not just about lipid transport anymore.Trends in endocrinology and metabolism: TEM, , 22 (1 ) ,9-15 More Information

Gordon, Scott M; Deng, Jingyuan; Lu, L Jason; Davidson, W Sean (2010. ) Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography.Journal of proteome research, , 9 (10 ) ,5239-49 More Information

Shen, Ling; Wang, David Q-H; Lo, Chun-Min; Tso, Patrick; Davidson, W Sean; Woods, Stephen C; Liu, Min (2010. ) Estradiol increases the anorectic effect of central apolipoprotein A-IV.Endocrinology, , 151 (7 ) ,3163-8 More Information

Perez-Tilve, Diego; Hofmann, Susanna M; Basford, Joshua; Nogueiras, Ruben; Pfluger, Paul T; Patterson, James T; Grant, Erin; Wilson-Perez, Hilary E; Granholm, Norman A; Arnold, Myrtha; Trevaskis, James L; Butler, Andrew A; Davidson, William S; Woods, Stephen C; Benoit, Stephen C; Sleeman, Mark W; DiMarchi, Richard D; Hui, David Y; Tschöp, Matthias H (2010. ) Melanocortin signaling in the CNS directly regulates circulating cholesterol.Nature neuroscience, , 13 (7 ) ,877-82 More Information

Smith, Loren E; Davidson, W Sean (2010. ) The role of hydrophobic and negatively charged surface patches of lipid-free apolipoprotein A-I in lipid binding and ABCA1-mediated cholesterol efflux.Biochimica et biophysica acta, , 1801 (1 ) ,64-9 More Information

Gordon, Scott; Durairaj, Anita; Lu, Jason L; Davidson, W Sean (2010. ) High-Density Lipoprotein Proteomics: Identifying New Drug Targets and Biomarkers by Understanding Functionality.Current cardiovascular risk reports, , 4 (1 ) ,1-8 More Information

Shen, Ling; Tso, Patrick; Wang, David Q-H; Woods, Stephen C; Davidson, W Sean; Sakai, Randall; Liu, Min (2009. ) Up-regulation of apolipoprotein E by leptin in the hypothalamus of mice and rats.Physiology & behavior, , 98 (1-2 ) ,223-8 More Information

Tubb, Matthew R; Smith, Loren E; Davidson, W Sean (2009. ) Purification of recombinant apolipoproteins A-I and A-IV and efficient affinity tag cleavage by tobacco etch virus protease.Journal of lipid research, , 50 (7 ) ,1497-504 More Information

Davidson, W Sean; Silva, R A Gangani D; Chantepie, Sandrine; Lagor, William R; Chapman, M John; Kontush, Anatol (2009. ) Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function.Arteriosclerosis, thrombosis, and vascular biology, , 29 (6 ) ,870-6 More Information

Lo, Chun-Min; Xu, Min; Yang, Qing; Zheng, Shuqin; Carey, Katherine M; Tubb, Matthew R; Davidson, W Sean; Liu, Min; Woods, Stephen C; Tso, Patrick (2009. ) Effect of intraperitoneal and intravenous administration of cholecystokinin-8 and apolipoprotein AIV on intestinal lymphatic CCK-8 and apo AIV concentration.American journal of physiology. Regulatory, integrative and comparative physiology, , 296 (1 ) ,R43-50 More Information

Sethi, Amar A; Stonik, John A; Thomas, Fairwell; Demosky, Steve J; Amar, Marcelo; Neufeld, Edward; Brewer, H Bryan; Davidson, W Sean; D'Souza, Wilissa; Sviridov, Dmitri; Remaley, Alan T (2008. ) Asymmetry in the lipid affinity of bihelical amphipathic peptides. A structural determinant for the specificity of ABCA1-dependent cholesterol efflux by peptides.The Journal of biological chemistry, , 283 (47 ) ,32273-82 More Information

Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean (2008. ) An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages.Journal of lipid research, , 49 (6 ) ,1322-32 More Information

Shen, Ling; Pearson, Kevin J; Xiong, Ye; Lo, Chun-Min; Tso, Patrick; Woods, Stephen C; Davidson, W Sean; Liu, Min (2008. ) Characterization of apolipoprotein A-IV in brain areas involved in energy homeostasis.Physiology & behavior, , 95 (1-2 ) ,161-7 More Information

Silva, R A Gangani D; Huang, Rong; Morris, Jamie; Fang, Jianwen; Gracheva, Elena O; Ren, Gang; Kontush, Anatol; Jerome, W Gray; Rye, Kerry-Anne; Davidson, W Sean (2008. ) Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes.Proceedings of the National Academy of Sciences of the United States of America, , 105 (34 ) ,12176-81 More Information

Tubb, Matthew R; Silva, R A Gangani D; Fang, Jianwen; Tso, Patrick; Davidson, W Sean (2008. ) A three-dimensional homology model of lipid-free apolipoprotein A-IV using cross-linking and mass spectrometry.The Journal of biological chemistry, , 283 (25 ) ,17314-23 More Information

Faulkner, Loren E; Panagotopulos, Stacey E; Johnson, Jacob D; Woollett, Laura A; Hui, David Y; Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean (2008. ) An analysis of the role of a retroendocytosis pathway in ABCA1-mediated cholesterol efflux from macrophages.Journal of lipid research, , 49 (6 ) ,1322-32 More Information

Oram, John F; Wolfbauer, Gertrud; Tang, Chongren; Davidson, W Sean; Albers, John J (2008. ) An amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.The Journal of biological chemistry, , 283 (17 ) ,11541-9 More Information

Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick (2007. ) Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 293 (4 ) ,R1490-4 More Information

Tubb, Matthew R; Silva, R A Gangani D; Pearson, Kevin J; Tso, Patrick; Liu, Min; Davidson, W Sean (2007. ) Modulation of apolipoprotein A-IV lipid binding by an interaction between the N and C termini.The Journal of biological chemistry, , 282 (39 ) ,28385-94 More Information

Davidson, W Sean; Thompson, Thomas B (2007. ) The structure of apolipoprotein A-I in high density lipoproteins.The Journal of biological chemistry, , 282 (31 ) ,22249-53 More Information

Vedhachalam, Charulatha; Ghering, Amy B; Davidson, W Sean; Lund-Katz, Sissel; Rothblat, George H; Phillips, Michael C (2007. ) ABCA1-induced cell surface binding sites for ApoA-I.Arteriosclerosis, thrombosis, and vascular biology, , 27 (7 ) ,1603-9 More Information

Shen, Ling; Tso, Patrick; Woods, Stephen C; Sakai, Randall R; Davidson, W Sean; Liu, Min (2007. ) Hypothalamic apolipoprotein A-IV is regulated by leptin.Endocrinology, , 148 (6 ) ,2681-9 More Information

Silva, R A Gangani D; Schneeweis, Lumelle A; Krishnan, Srinivasan C; Zhang, Xiuqi; Axelsen, Paul H; Davidson, W Sean (2007. ) The structure of apolipoprotein A-II in discoidal high density lipoproteins.The Journal of biological chemistry, , 282 (13 ) ,9713-21 More Information

Ghering, Amy B; Davidson, W Sean (2006. ) Ceramide structural features required to stimulate ABCA1-mediated cholesterol efflux to apolipoprotein A-I.Journal of lipid research, , 47 (12 ) ,2781-8 More Information

Davidson, W Sean; Ghering, Amy B; Beish, Lauren; Tubb, Matthew R; Hui, David Y; Pearson, Kevin (2006. ) The biotin-capture lipid affinity assay: a rapid method for determining lipid binding parameters for apolipoproteins.Journal of lipid research, , 47 (2 ) ,440-9 More Information

Gotoh, Koro; Liu, Min; Benoit, Stephen C; Clegg, Deborah J; Davidson, W Sean; D'Alessio, David; Seeley, Randy J; Tso, Patrick; Woods, Stephen C (2006. ) Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake.American journal of physiology. Regulatory, integrative and comparative physiology, , 290 (1 ) ,R202-7 More Information

Kodvawala, Ahmer; Ghering, Amy B; Davidson, W Sean; Hui, David Y (2005. ) Carboxyl ester lipase expression in macrophages increases cholesteryl ester accumulation and promotes atherosclerosis.The Journal of biological chemistry, , 280 (46 ) ,38592-8 More Information

Pearson, Kevin; Tubb, Matthew R; Tanaka, Masafumi; Zhang, Xiu Qi; Tso, Patrick; Weinberg, Richard B; Davidson, W Sean (2005. ) Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association.The Journal of biological chemistry, , 280 (46 ) ,38576-82 More Information

Silva, R A Gangani D; Hilliard, George M; Li, Ling; Segrest, Jere P; Davidson, W Sean (2005. ) A mass spectrometric determination of the conformation of dimeric apolipoprotein A-I in discoidal high density lipoproteins.Biochemistry, , 44 (24 ) ,8600-7 More Information

Davidson, W Sean; Silva, R A Gangani D (2005. ) Apolipoprotein structural organization in high density lipoproteins: belts, bundles, hinges and hairpins. Current opinion in lipidology, , 16 (3 ) ,295-300

Pearson, Kevin; Liu, Min; Shen, Ling; Tso, Patrick; Davidson, W Sean (2005. ) Bacterial expression and characterization of rat apolipoprotein E.Protein expression and purification, , 41 (2 ) ,447-53 More Information

Silva, R A Gangani D; Hilliard, George M; Fang, Jianwen; Macha, Stephen; Davidson, W Sean (2005. ) A three-dimensional molecular model of lipid-free apolipoprotein A-I determined by cross-linking/mass spectrometry and sequence threading.Biochemistry, , 44 (8 ) ,2759-69 More Information

Maiorano, J Nicholas; Jandacek, Ronald J; Horace, Erica M; Davidson, W Sean (2004. ) Identification and structural ramifications of a hinge domain in apolipoprotein A-I discoidal high-density lipoproteins of different size.Biochemistry, , 43 (37 ) ,11717-26 More Information

Pearson, Kevin; Saito, Hiroyuki; Woods, Stephen C; Lund-Katz, Sissel; Tso, Patrick; Phillips, Michael C; Davidson, W Sean (2004. ) Structure of human apolipoprotein A-IV: a distinct domain architecture among exchangeable apolipoproteins with potential functional implications.Biochemistry, , 43 (33 ) ,10719-29 More Information

Davidson, W Sean (2004. ) 5th Annual International Conference on HDL Cholesterol: metabolic pathways and drug developments.Expert opinion on therapeutic targets, , 8 (4 ) ,359-66 More Information

Vowinkel, Thorsten; Mori, Mikiji; Krieglstein, Christian F; Russell, Janice; Saijo, Fumito; Bharwani, Sulaiman; Turnage, Richard H; Davidson, W Sean; Tso, Patrick; Granger, D Neil; Kalogeris, Theodore J (2004. ) Apolipoprotein A-IV inhibits experimental colitis.The Journal of clinical investigation, , 114 (2 ) ,260-9 More Information

Narayanaswami, Vasanthy; Maiorano, J Nicholas; Dhanasekaran, Padmaja; Ryan, Robert O; Phillips, Michael C; Lund-Katz, Sissel; Davidson, W Sean (2004. ) Helix orientation of the functional domains in apolipoprotein e in discoidal high density lipoprotein particles.The Journal of biological chemistry, , 279 (14 ) ,14273-9 More Information

Witting, Scott R; Maiorano, J Nicholas; Davidson, W Sean (2003. ) Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.The Journal of biological chemistry, , 278 (41 ) ,40121-7 More Information

Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A (2003. ) Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation.Journal of lipid research, , 44 (10 ) ,1909-18 More Information

Davidson, W Sean; Hilliard, George M (2003. ) The spatial organization of apolipoprotein A-I on the edge of discoidal high density lipoprotein particles: a mass specrometry study.The Journal of biological chemistry, , 278 (29 ) ,27199-207 More Information

Liu, Min; Maiorano, Nick; Shen, Ling; Pearson, Kevin; Tajima, Daisuke; Zhang, Dian Ming; Woods, Stephen C; Seeley, Randy J; Davidson, W Sean; Tso, Patrick (2003. ) Expression of biologically active rat apolipoprotein AIV in Escherichia coli. Physiology & behavior, , 78 (1 ) ,149-55

Schmid, Kara E; Davidson, W Sean; Myatt, Leslie; Woollett, Laura A (2003. ) Transport of cholesterol across a BeWo cell monolayer: implications for net transport of sterol from maternal to fetal circulation.Journal of lipid research, , 44 (10 ) ,1909-18 More Information

Panagotopulos, Stacey E; Witting, Scott R; Horace, Erica M; Hui, David Y; Maiorano, J Nicholas; Davidson, W Sean (2002. ) The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1.The Journal of biological chemistry, , 277 (42 ) ,39477-84 More Information

Reschly, Erica J; Sorci-Thomas, Mary G; Davidson, W Sean; Meredith, Stephen C; Reardon, Catherine A; Getz, Godfrey S (2002. ) Apolipoprotein A-I alpha -helices 7 and 8 modulate high density lipoprotein subclass distribution.The Journal of biological chemistry, , 277 (12 ) ,9645-54 More Information

Panagotopulos, S E; Horace, E M; Maiorano, J N; Davidson, W S (2001. ) Apolipoprotein A-I adopts a belt-like orientation in reconstituted high density lipoproteins.The Journal of biological chemistry, , 276 (46 ) ,42965-70 More Information

Safi, W; Maiorano, J N; Davidson, W S (2001. ) A proteolytic method for distinguishing between lipid-free and lipid-bound apolipoprotein A-I. Journal of lipid research, , 42 (5 ) ,864-72

Maiorano, J N; Davidson, W S (2000. ) The orientation of helix 4 in apolipoprotein A-I-containing reconstituted high density lipoproteins.The Journal of biological chemistry, , 275 (23 ) ,17374-80 More Information

Davidson, W S; Arnvig-McGuire, K; Kennedy, A; Kosman, J; Hazlett, T L; Jonas, A (1999. ) Structural organization of the N-terminal domain of apolipoprotein A-I: studies of tryptophan mutants. Biochemistry, , 38 (43 ) ,14387-95

Woods, M O; Young, T L; Parfrey, P S; Hefferton, D; Green, J S; Davidson, W S (1999. ) Genetic heterogeneity of Bardet-Biedl syndrome in a distinct Canadian population: evidence for a fifth locus.Genomics, , 55 (1 ) ,2-9 More Information

Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C (1998. ) Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization. Journal of lipid research, , 39 (10 ) ,1918-28

Davidson, W S; Jonas, A; Clayton, D F; George, J M (1998. ) Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. The Journal of biological chemistry, , 273 (16 ) ,9443-9

Davidson, W S; Hazlett, T; Mantulin, W W; Jonas, A (1996. ) The role of apolipoprotein AI domains in lipid binding. Proceedings of the National Academy of Sciences of the United States of America, , 93 (24 ) ,13605-10

Lund-Katz, S; Murley, Y M; Yon, E; Gillotte, K L; Davidson, W S (1996. ) Comparison of the structural and functional effects of monomeric and dimeric human apolipoprotein A-II in high density lipoprotein particles. Lipids, , 31 (11 ) ,1107-13

Gillotte, K L; Davidson, W S; Lund-Katz, S; Rothblat, G H; Phillips, M C (1996. ) Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux. The Journal of biological chemistry, , 271 (39 ) ,23792-8

McGuire, K A; Davidson, W S; Jonas, A (1996. ) High yield overexpression and characterization of human recombinant proapolipoprotein A-I. Journal of lipid research, , 37 (7 ) ,1519-28

Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C (1995. ) Effects of the neutral lipid content of high density lipoprotein on apolipoprotein A-I structure and particle stability. The Journal of biological chemistry, , 270 (45 ) ,26910-7

Davidson, W S; Rodrigueza, W V; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C (1995. ) Effects of acceptor particle size on the efflux of cellular free cholesterol. The Journal of biological chemistry, , 270 (29 ) ,17106-113

Bruce, C; Davidson, W S; Kussie, P; Lund-Katz, S; Phillips, M C; Ghosh, R; Tall, A R (1995. ) Molecular determinants of plasma cholesteryl ester transfer protein binding to high density lipoproteins. The Journal of biological chemistry, , 270 (19 ) ,11532-42

Davidson, W S; Gillotte, K L; Lund-Katz, S; Johnson, W J; Rothblat, G H; Phillips, M C (1995. ) The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol. The Journal of biological chemistry, , 270 (11 ) ,5882-90

Davidson, W S; Lund-Katz, S; Johnson, W J; Anantharamaiah, G M; Palgunachari, M N; Segrest, J P; Rothblat, G H; Phillips, M C (1994. ) The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. The Journal of biological chemistry, , 269 (37 ) ,22975-82

Davidson, W S; Sparks, D L; Lund-Katz, S; Phillips, M C (1994. ) The molecular basis for the difference in charge between pre-beta- and alpha-migrating high density lipoproteins. The Journal of biological chemistry, , 269 (12 ) ,8959-65

Sparks, D L; Davidson, W S; Lund-Katz, S; Phillips, M C (1993. ) Effect of cholesterol on the charge and structure of apolipoprotein A-I in recombinant high density lipoprotein particles. The Journal of biological chemistry, , 268 (31 ) ,23250-7

McLean, L R; Hagaman, K A; Davidson, W S (1993. ) Role of lipid structure in the activation of phospholipase A2 by peroxidized phospholipids. Lipids, , 28 (6 ) ,505-9

McLean, L R; Hagaman, K A; Owen, T J; Payne, M H; Davidson, W S; Krstenansky, J L (1991. ) Examination of the peptide sequence requirements for lipid-binding. Alternative pathways for promoting the interaction of amphipathic alpha-helical peptides with phosphatidylcholine. Biochimica et biophysica acta, , 1086 (1 ) ,106-14

Mythreye, Karthikeyan; Satterwhite, Lisa L; Davidson, W Sean; Goldschmidt-Clermont, Pascal J ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair.Biochimica et biophysica acta, , 1781 (11-12 ) ,703-9 More Information

Toth, Peter P; Barter, Philip J; Rosenson, Robert S; Boden, William E; Chapman, M John; Cuchel, Marina; D'Agostino, Ralph B; Davidson, Michael H; Davidson, W Sean; Heinecke, Jay W; Karas, Richard H; Kontush, Anatol; Krauss, Ronald M; Miller, Michael; Rader, Daniel J High-density lipoproteins: a consensus statement from the National Lipid Association.Journal of clinical lipidology, , 7 (5 ) ,484-525 More Information

Shah, Amy S; Davidson, W Sean; Gao, Zhiqian; Dolan, Lawrence M; Kimball, Thomas R; Urbina, Elaine M Superiority of lipoprotein particle number to detect associations with arterial thickness and stiffness in obese youth with and without prediabetes.Journal of clinical lipidology, , 10 (3 ) ,610-8 More Information

Swertfeger, Debi K; Rebholz, Sandra; Li, Hailong; Shah, Amy S; Davidson, William Sean; Lu, Long J Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high-density lipoproteins.Journal of clinical lipidology, , 12 (6 ) ,1539-1548 More Information

Davidson, W Sean; Shah, Amy S High-Density Lipoprotein Subspecies in Health and Human Disease: Focus on Type 2 Diabetes.Methodist DeBakey cardiovascular journal, , 15 (1 ) ,55-61 More Information

Honors and Awards

2000 "Established Investigator" American Heart Association

2003 Richard Akeson Excellence in Graduate Teaching Award

2000 Teacher of the Year (Pathology and Molecular Medicine Graduate Program)

2001 Teacher of the Year (Pathology and Molecular Medicine Graduate Program)

2003 Teacher of the Year (Pathology and Molecular Medicine Graduate Program)

2004 Teacher of the Year (Pathology and Molecular Medicine Graduate Program)

2004 Peter Dolphin Award for outstanding contributions to HDL research (International HDL Awards Program)

Contact Information

Research - University of Cincinnati Reading Campus
2120 East Galbraith Rd.
Cincinnati  Ohio, 45237
Phone: 5135583707
Fax: 5135581312
Sean.Davidson@uc.edu