George Deepe

George S Deepe , MD

Professor

Vice Chair

Medical Sciences Building
Room 6152
231 Albert Sabin Way
Cincinnati, Ohio 45267-0560
Phone 513-558-4704
Fax 513-558-2089
Email george.deepe@uc.edu

Professional Summary

Dr. Deepe is a well-recognized leader in the cellular immunology of fungal infections. His specific research interests involve characterization of the protective T-cell epitopes of H. capsulatum antigens and analysis of the functional activity of antigen-reactive T-cells. He is board certified in both internal medicine and infectious diseases. Dr. Deepe's published works include approximately 100 original publications and 36 abstracts. He has been elected to membership in the Association of American Physicians, American Society for Microbiology, The American Association for the Advancement of Science, American College of Physicians, American Federation for Clinical Research, International Society for Human and Animal Mycology, American Association of Immunologists, Central Society for Clinical Research and a Fellow in the Infectious Diseases Society of America. Dr. Deepe is a member of the editorial board of infection and immunity and a reviewer for Infection and Immunity, Journal of Immunology, Journal of Leukocyte Biology, Journal of Infectious Diseases, Journal of Clinical Investigation and Clinical Infectious Diseases.

Education

Bachelor's Degree: Kenyon College 1971

Medical Degree: University of Cincinnati College of Medicine 1976

Residency: Southern Illinois School of Medicine 1979 (Internal Medicine)

Fellowship : University of Kentucky College of Medicine 1980 (Infectious Diseases )

Fellowship : University of Cincinnati College of Medicine 1981 (Infectious Diseases )

Certifications

American Board of Internal Medicine (Infectious Disease) (Certification Date: 11-09-1982 )

American Board of Internal Medicine (Certification Date: 09-12-1979 )

Clinical Interests

Infectious Disease

Histoplasmosis

Pneumonia

Specialities

Infectious Disease

Internal Medicine

Research and Practice Interests

I have been involved in the study of the host response to the pathogenic fungus, Histoplasma capsulatum for over 25 years. I have devoted the large majority of our work on the role of the innate and adaptive immune response to this fungus. The laboratory has made several notable observations that have distinguished the interaction of this intracellular pathogen from that of other microbes. Moreover, some of these finding can be linked to the clinical spectrum, especially our observations regarding the role of tumor necrosis factor-a. Other contributions include the study of the role of regulatory T cells and histoplasmosis, the role chemokines in this disease, and the study of metal regulation by colony stimulating factors. We are exceedingly interested in how zinc regulation dictates the functional attributes of macrophages infected with H. capsulatum. We use a variety of techniques to examine the role of zinc. We have partnered with the Department of Chemistry and bioinformaticians to pursue how zinc and zinc binding proteins shape the biological activity of macrophages. We have extended our work into the examination of transcription factor regulation of macrophages and dendritic cells. For the former hypoxia-inducing factor (HIF) is required for an intact innate immune response to challenge with this organism. We have demonstrated that the absence of HIF-1a in macrophages causes collapse of the immune system. This detrimental effect is caused by elevated interleukin-10 production. For dendritic cells, we have discovered that Krüppel-like factor (KLF) 2 is necessary for these cells to regulate the emergence of T helper type 2 cells that produce interleukin-4 which is detrimental in both intracellular infections and in asthma.  When dendritic cells lack KLF2 they upregulate a Notch ligand, Jagged 2, on dendritic cells. This ligand drives the emergence of Th2. The impact of KLF2 is via HIF-1a.
 

Positions and Work Experience

1982 -1983 Instructor in Medicine, University of Cincinnati College of Medicine,

1983 -1989 Assistant Professor of Medicine, University of Cincinnati College of Medicine,

1989 -1996 Associate Professor of Medicine, University of Cincinnati College of Medicine,

1991 -1992 Visiting Professor of Medicine, Stanford University School of Medicine,

1996 - Professor of Medicine, University of Cincinnati College of Medicine,

1994 -2009 Chief, Division of Infectious Diseases, University of Cincinnati College of Medicine,

Research Support

Grant: #R01 AI-73337-03 05-15-2008 -05-14-2013 NIH/NIAID Immunopathogenesis in Histoplasmosis $250,000

Grant: #R01 AI-83313-02 02-01-2010 -01-31-2015 NIH/NIAID Chemokine-Cytokine Nexus in Fungal Immunity $250,000 Type:Grant

Grant: #1R21-094971-01 02-15-2011 -02-14-2013 NIH/NIAID GM-CSF Regulation of Zinc in Histoplasmosis $150,000

Grant: #1R21-096823-01 05-10-2011 -05-09-2013 NIH/NIAID Myeloid cell KLF2 and IL-4 in Histoplasmosis $150,000

Grant: #1I01BX000717-02 04-01-2010 -03-31-2014 Merit Review Veterans Affairs Molecular and Cellular Determinants of Immunity in Histoplasmosis $150,000

Grant: #R01AI106269-01 Investigators:George Deepe, Joseph Caruso, Alexey Porollo 05-15-2013 -05-14-2018 NIAID GM-CSF-Induced Metal Sequestration and Histoplasma Role:PI 281,000 Active Type:Grant Level:National

Grant: #P01 AI061298 Investigators:Deepe, George 06-01-2004 -05-31-2010 National Institute of Allergy and Infectious Diseases Defending Against Systemic Mycoses Role:PI $3,777,601.00 Closed Level:Federal

Investigators:Deepe, George 07-01-2004 -01-05-2007 Amgen, Inc TNF Inhibition and Susceptibility to Histoplasmosis Role:PI $60,000.00 Closed Level:Industry

Grant: #5-R01-HL-55949-05-A0-S0-E0 Investigators:Deepe, George 09-30-1995 -08-31-2000 National Heart, Lung and Blood Institute Molecular Pathogenesis of Pulmonary Histoplasmosis Role:PI $389,684.00 Closed Level:Federal

Grant: #5-R37-AI-42747-05-A0-S0-E0 Investigators:Deepe, George 07-15-1997 -06-30-2002 National Institute of Allergy and Infectious Diseases T Cell Receptor Usage in Pulmonary Histoplasmosis Role:PI $1,112,564.00 Closed Level:Federal

Grant: #5-R01-AI-34361-10-A0-S0-E0 Investigators:Deepe, George 07-01-1998 -06-30-2003 National Institute of Allergy and Infectious Diseases Protective Antigens from Histoplasma Capsulatum Role:PI $1,373,377.00 Closed Level:Federal

Grant: #R01 AI106269 Investigators:Caruso, Joseph; Deepe, George; Porollo, Alexey 05-15-2013 -04-30-2018 National Institute of Allergy and Infectious Diseases GM-CSF-Induced Metal Sequestration and Histoplasma Role:PI $445,048.00 Active Level:Federal

Grant: #T32GM063483 Investigators:Deepe, George; Herr, Andrew; Khurana-Hershey, Gurjit 07-01-2013 -06-30-2018 National Institute of General Medical Sciences Medical Scientist Training Program Role:Collaborator $277,195.00 Active Level:Federal

Grant: #R21 AI094971 Investigators:Caruso, Joseph; Deepe, George 02-15-2011 -01-31-2014 National Institute of Allergy and Infectious Diseases Zinc and Histoplasma Role:PI $431,750.00 Active Level:Federal

Grant: #WA00148596/RFS2014100 / 1 R01 AI102618 Investigators:Deepe, George 08-06-2013 -07-31-2017 National Institute of Allergy and Infectious Diseases Glucan particles as a vaccine platform to protect against emerging diseases Role:PI $212,071.00 Awarded Level:Federal

Grant: #1R01AI126818 Investigators:Deepe, George 06-10-2016 -05-31-2021 National Institute of Allergy and Infectious Diseases Dendritic cell KLF2/Notch Axis and Th2 Responses to Eukaryotic Pathogens Role:PI $512,675.00 Active Level:Federal

Grant: #CCHMC Billing Agreement - Travers sub F30DK109573 Investigators:Deepe, George; Travers, Jared 07-01-2017 -03-31-2018 National Inst of Diabetes and Digestive and Kidney Disease Role of nuclear IL-33 in mucosal inflammation F30 - Travers Role:Collaborator $30,479.00 Active Level:Federal

Grant: #Billing Agreement (Melgar) / F31CA217140 Investigators:Deepe, George; Melgar, Katelyn 05-01-2017 -04-30-2018 National Cancer Institute Novel mechanisms and therapeutic strategies of refractory leukemia F31 - Melgar Role:PI $28,160.00 Active Level:Federal

Grant: #CCHMC Billing Agreement 135895 / 5F30DK107199-02 Investigators:Deepe, George; Jiang, Tianlun 05-01-2017 -04-30-2018 National Inst of Diabetes and Digestive and Kidney Disease Antifungal immunity controlled bycommensal intestinal bacteria F30 - Jiang Role:Collaborator $33,812.00 Awarded Level:Federal

Grant: #R01AI133797 Investigators:Deepe, George 02-15-2018 -01-31-2023 National Institute of Allergy and Infectious Diseases HIF Regulation of Histoplasma Pathogenesis Role:PI $399,479.00 Active Level:Federal

Grant: #R01 AI106269 Investigators:Deepe, George; Landero Figueroa, Julio; Subramanian, Kavitha 07-01-2018 -06-30-2023 National Institute of Allergy and Infectious Diseases GM-CSF-Induced Metal Sequestration and Histoplasma Role:PI $540,531.00 Active Level:Federal

Grant: #OSP29546-00 / NIAID 75N93019C00064 Investigators:Deepe, George 09-30-2019 -09-29-2020 National Institute of Allergy and Infectious Diseases Identification of human T cell epitopes of pathogenic fungi Role:PI $117,679.00 Awarded Level:Federal

Grant: #Intersect Fellowship Investigators:Deepe, George 01-15-2021 -01-14-2022 American Association of Immunologists, Inc. The interplay between metallothioneins and metabolism in epigenetic reprograming of T cells. Role:PI $57,456.00 Awarded Level:Private Non-Profit

Grant: #R21AI160722 Investigators:Deepe, George 04-01-2021 -03-31-2023 National Institute of Allergy and Infectious Diseases Immunopathogenesis of Histoplasmosis and TNF Role:PI $249,963.00 Awarded Level:Federal

Grant: #R56 AI107036 Investigators:Askew, David; Davidson, William; Deepe, George 08-15-2013 -07-31-2015 National Institute of Allergy and Infectious Diseases High-density lipoprotein and A. fumigatus pathogenesis Role:Collaborator $358,728.00 Closed Level:Federal

Grant: #University of Illinois 103177-18342 / R01AI153522 Investigators:Deepe, George 04-01-2021 -12-31-2025 National Institute of Allergy and Infectious Diseases Immunity against fungal infections Role:PI 21382.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Kroetz, Danielle N; Deepe, George S (2011. ) An Aberrant Thymus in CCR5-/- Mice Is Coupled with an Enhanced Adaptive Immune Response in Fungal Infection.Journal of immunology (Baltimore, Md. : 1950), , 186 (10 ) ,5949-55 More Information

Szymczak, W. A.; Deepe, G. S., Jr. (2009. ) The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity .J Immunol, , 183 (3 ) ,1964-74

Mora-Montes, Héctor M; Netea, Mihai G; Ferwerda, Gerben; Lenardon, Megan D; Brown, Gordon D; Mistry, Anita R; Kullberg, Bart Jan; O'Callaghan, Chris A; Sheth, Chirag C; Odds, Frank C; Brown, Alistair J P; Munro, Carol A; Gow, Neil A R; Deepe, G S (2011. ) Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin.Infection and immunity, , 79 (5 ) ,1961-70 More Information

Szymczak, W. A.; Deepe, G. S., Jr. (2010. ) Antigen-presenting dendritic cells rescue CD4-depleted CCR2 .Infect Immun, , 78 (5 ) ,2125-37

Winters, Michael S; Chan, Qilin; Caruso, Joseph A; Deepe, George S (2010. ) Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses.The Journal of infectious diseases, , 202 (7 ) ,1136-45 More Information

Kroetz, D. N.; Deepe, G. S., Jr. (2010. ) CCR5 dictates the equilibrium of proinflammatory IL-17 .J Immunol, , 184 (9 ) ,5224-31

Szymczak, Wendy A; Deepe, George S (2010. ) Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection.Infection and immunity, , 78 (5 ) ,2125-37 More Information

Deepe, G. S., Jr. (2010. ) Histoplasma capsulatum .2 ,3305-3318

Kroetz, Danielle N; Deepe, George S (2010. ) CCR5 dictates the equilibrium of proinflammatory IL-17+ and regulatory Foxp3+ T cells in fungal infection.Journal of immunology (Baltimore, Md. : 1950), , 184 (9 ) ,5224-31 More Information

Winters, M. S.; Chan, Q.; Caruso, J. A.; Deepe, G. S., Jr. (2010. ) Metallomic analysis of macrophages infected with Histoplasma capsulatum reveals a fundamental role for zinc in host defenses .J Infect Dis, , 202 (7 ) ,1136-45

Szymczak, Wendy A; Deepe, George S (2009. ) The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity.Journal of immunology (Baltimore, Md. : 1950), , 183 (3 ) ,1964-74 More Information

Kroetz, D. N.; Deepe, G. S., Jr. (2011. ) An aberrant thymus in CCR5 .J Immunol, , 186 (10 ) ,5949-55

Deepe, George S; Gibbons, Reta S (2009. ) Interleukins 17 and 23 influence the host response to Histoplasma capsulatum.The Journal of infectious diseases, , 200 (1 ) ,142-51 More Information

Kroetz, D. N.; Deepe, G. S., Jr. (2012. ) CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor .J Immunol, , 205 (6 ) ,955-63

Winters, Michael S; Spellman, Daniel S; Chan, Qilin; Gomez, Francisco J; Hernandez, Margarita; Catron, Brittany; Smulian, Alan G; Neubert, Thomas A; Deepe, George S (2008. ) Histoplasma capsulatum proteome response to decreased iron availability.Proteome science, , 6 ,36 More Information

Deepe, G. S., Jr.; Buesing, W. R. (2012. ) Deciphering the pathways of death of .188 (1 ) ,334-44

Medeiros, Alexandra I; Sá-Nunes, Anderson; Turato, Walter M; Secatto, Adriana; Frantz, Fabiani G; Sorgi, Carlos A; Serezani, Carlos H; Deepe, George S; Faccioli, Lúcia H (2008. ) Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells. Journal of immunology (Baltimore, Md. : 1950), , 181 (12 ) ,8544-51

Kroetz, D. N.; Deepe, G. S. (2012. ) The role of cytokines and chemokines in .Cytokine, , 58 (1 ) ,112-7

Chagas, Ronney Fernandes; Bailão, Alexandre Melo; Pereira, Maristela; Winters, Michael S; Smullian, Alan George; Deepe, George S; de Almeida Soares, Célia Maria (2008. ) The catalases of Paracoccidioides brasiliensis are differentially regulated: protein activity and transcript analysis.Fungal genetics and biology : FG & B, , 45 (11 ) ,1470-8 More Information

de Bastos Ascenço Soares, Renata; Gomez, Francisco J; de Almeida Soares, Célia Maria; Deepe, George S (2008. ) Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection.Infection and immunity, , 76 (9 ) ,4214-21 More Information

Deepe, George S; Gibbons, Reta S; Smulian, A George (2008. ) Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs.Journal of leukocyte biology, , 84 (3 ) ,669-78 More Information

Deepe, George S; Gibbons, Reta S (2008. ) TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), , 180 (2 ) ,1088-97

Smulian, A George; Gibbons, Reta S; Demland, Jeffery A; Spaulding, Deborah T; Deepe, George S (2007. ) Expression of hygromycin phosphotransferase alters virulence of Histoplasma capsulatum.Eukaryotic cell, , 6 (11 ) ,2066-71 More Information

Deepe, George S (2007. ) Tumor necrosis factor-alpha antagonism by the murine tumor necrosis factor-alpha receptor 2-Fc fusion protein exacerbates histoplasmosis in mice.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, , 27 (6 ) ,471-80 More Information

Dann, Frank J; Gottlieb, Alice B; Deepe, George S; Flynn, JoAnne L; Wallis, Robert S; Thompson, Elizabeth H Z; Louie, James S (2007. ) Structural-functional relationships of TNF-alpha antagonists: next steps.The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, , 12 (1 ) ,46-7 More Information

Deepe, George S (2007. ) Tumor necrosis factor-alpha and host resistance to the pathogenic fungus, Histoplasma capsulatum.The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, , 12 (1 ) ,34-7 More Information

Wüthrich, Marcel; Filutowicz, Hanna I; Allen, Holly L; Deepe, George S; Klein, Bruce S (2007. ) V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis.Infection and immunity, , 75 (1 ) ,193-200 More Information

Cutler, Jim E; Deepe, George S; Klein, Bruce S (2007. ) Advances in combating fungal diseases: vaccines on the threshold.Nature reviews. Microbiology, , 5 (1 ) ,13-28 More Information

Deepe, George S; McGuinness, Michael (2006. ) Interleukin-1 and host control of pulmonary histoplasmosis.The Journal of infectious diseases, , 194 (6 ) ,855-64 More Information

Allen, Holly L; Deepe, George S (2006. ) B cells and CD4-CD8- T cells are key regulators of the severity of reactivation histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), , 177 (3 ) ,1763-71

Scheckelhoff, Mark R; Deepe, George S (2006. ) Pulmonary V beta 4+ T cells from Histoplasma capsulatum-infected mice respond to a homologue of Sec31 that confers a protective response.The Journal of infectious diseases, , 193 (6 ) ,888-97 More Information

Deepe, George S; Gibbons, Reta S (2006. ) T cells require tumor necrosis factor-alpha to provide protective immunity in mice infected with Histoplasma capsulatum.The Journal of infectious diseases, , 193 (2 ) ,322-30 More Information

Allen, Holly L; Deepe, George S (2005. ) Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum.The Journal of clinical investigation, , 115 (10 ) ,2875-85 More Information

Deepe, George S (2005. ) Modulation of infection with Histoplasma capsulatum by inhibition of tumor necrosis factor-alpha activity.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 41 Suppl 3 ,S204-7 More Information

Deepe, George S; Smelt, Sara; Louie, James S (2005. ) Tumor necrosis factor inhibition and opportunistic infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 41 Suppl 3 ,S187-8 More Information

Deepe, George S; Wüthrich, Marcel; Klein, Bruce S (2005. ) Progress in vaccination for histoplasmosis and blastomycosis: coping with cellular immunity. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 43 (5 ) ,381-9

Scheckelhoff, Mark; Deepe, George S (2005. ) A deficiency in gamma interferon or interleukin-10 modulates T-Cell-dependent responses to heat shock protein 60 from Histoplasma capsulatum.Infection and immunity, , 73 (4 ) ,2129-34 More Information

Borges, Clayton L; Pereira, Maristela; Felipe, Maria S S; de Faria, Fabrícia P; Gomez, Francisco J; Deepe, George S; Soares, Célia M A (2005. ) The antigenic and catalytically active formamidase of Paracoccidioides brasiliensis: protein characterization, cDNA and gene cloning, heterologous expression and functional analysis of the recombinant protein.Microbes and infection / Institut Pasteur, , 7 (1 ) ,66-77 More Information

Deepe, George S (2004. ) Preventative and therapeutic vaccines for fungal infections: from concept to implementation.Expert review of vaccines, , 3 (6 ) ,701-9 More Information

Barton, Lance F; Runnels, Herbert A; Schell, Todd D; Cho, Yunjung; Gibbons, Reta; Tevethia, Satvir S; Deepe, George S; Monaco, John J (2004. ) Immune defects in 28-kDa proteasome activator gamma-deficient mice. Journal of immunology (Baltimore, Md. : 1950), , 172 (6 ) ,3948-54

Deepe, George S; Gibbons, Reta S (2003. ) Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. Journal of immunology (Baltimore, Md. : 1950), , 171 (10 ) ,5353-62

Nosanchuk, Joshua D; Steenbergen, Judith N; Shi, Li; Deepe, George S; Casadevall, Arturo (2003. ) Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum.The Journal of clinical investigation, , 112 (8 ) ,1164-75 More Information

McCormack, Francis X; Gibbons, Reta; Ward, Susan R; Kuzmenko, Alexander; Wu, Huixing; Deepe, George S (2003. ) Macrophage-independent fungicidal action of the pulmonary collectins.The Journal of biological chemistry, , 278 (38 ) ,36250-6 More Information

Huffnagle, Gary B; Deepe, George S (2003. ) Innate and adaptive determinants of host susceptibility to medically important fungi. Current opinion in microbiology, , 6 (4 ) ,344-50

Gildea, Lucy A; Gibbons, Reta; Finkelman, Fred D; Deepe, George S (2003. ) Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum. Infection and immunity, , 71 (7 ) ,3787-93

Wuthrich, Marcel; Filutowicz, Hanna I; Warner, Tom; Deepe, George S; Klein, Bruce S (2003. ) Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts.The Journal of experimental medicine, , 197 (11 ) ,1405-16 More Information

Guedes, Herbert Leonel de Matos; Guimarães, Allan Jefferson; Muniz, Mauro de Medeiros; Pizzini, Claudia Vera; Hamilton, Andrew John; Peralta, José Mauro; Deepe, George S; Zancopé-Oliveira, Rosely M (2003. ) PCR assay for identification of histoplasma capsulatum based on the nucleotide sequence of the M antigen. Journal of clinical microbiology, , 41 (2 ) ,535-9

Scheckelhoff, Mark; Deepe, George S (2002. ) The protective immune response to heat shock protein 60 of Histoplasma capsulatum is mediated by a subset of V beta 8.1/8.2+ T cells. Journal of immunology (Baltimore, Md. : 1950), , 169 (10 ) ,5818-26

Barton, Lance F; Cruz, Miguel; Rangwala, Reshma; Deepe, George S; Monaco, John J (2002. ) Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection. Journal of immunology (Baltimore, Md. : 1950), , 169 (6 ) ,3046-52

Deepe, George S; Gibbons, Reta S (2002. ) Functional properties of the T cell receptor repertoire in responding to the protective domain of heat-shock protein 60 from Histoplasma capsulatum.The Journal of infectious diseases, , 186 (6 ) ,815-22 More Information

Costa, Alessandra A; Gómez, Francisco J; Pereira, Maristela; Felipe, M Sueli S; Jesuino, Rosália S A; Deepe, George S; de Almeida Soares, Célia M (2002. ) Characterization of a gene which encodes a mannosyltransferase homolog of Paracoccidioides brasiliensis. Microbes and infection / Institut Pasteur, , 4 (10 ) ,1027-34

Deepe, George S; Gibbons, Reta S (2002. ) Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum. Infection and immunity, , 70 (7 ) ,3759-67

Cunha, Daniela A; Zancopé-Oliveira, Roseli M; Sueli, M; Felipe, S; Salem-Izacc, Silvia M; Deepe, George S; Soares, Célia M A (2002. ) Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis. Clinical and diagnostic laboratory immunology, , 9 (2 ) ,374-7

Deepe, George S; Gibbons, Reta S; Ward, Susan R (2002. ) Discordance between T-cell receptor expression and effector function in mice infected with Histoplasma capsulatum. Infection and immunity, , 70 (3 ) ,1648-52

Izacc, S M; Gomez, F J; Jesuino, R S; Fonseca, C A; Felipe, M S; Deepe, G S; Soares, C M (2001. ) Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 39 (5 ) ,445-55

Deepe, G S; Gibbons, R (2001. ) V beta 6+ T cells are obligatory for vaccine-induced immunity to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), , 167 (4 ) ,2219-26

Deepe, G S; Gibbons, R (2001. ) Protective efficacy of H antigen from Histoplasma capsulatum in a murine model of pulmonary histoplasmosis.Infection and immunity, , 69 (5 ) ,3128-34 More Information

Gomez, F J; Woodward, E O; Pilcher-Roberts, R; Gibbons, R S; Deepe, G S (2001. ) V beta 6+ and V beta 4+ T cells exert cooperative activity in clearance of secondary infection with Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), , 166 (4 ) ,2855-62

Deepe, G S; Gibbons, R (2000. ) Recombinant murine granulocyte-macrophage colony-stimulating factor modulates the course of pulmonary histoplasmosis in immunocompetent and immunodeficient mice. Antimicrobial agents and chemotherapy, , 44 (12 ) ,3328-36

Allendoerfer, R; Deepe, G S (2000. ) Regulation of infection with Histoplasma capsulatum by TNFR1 and -2. Journal of immunology (Baltimore, Md. : 1950), , 165 (5 ) ,2657-64

Deepe, G S (2000. ) Immune response to early and late Histoplasma capsulatum infections. Current opinion in microbiology, , 3 (4 ) ,359-62

Cain, J A; Deepe, G S (2000. ) Interleukin-12 neutralization alters lung inflammation and leukocyte expression of CD80, CD86, and major histocompatibility complex class II in mice infected with Histoplasma capsulatum. Infection and immunity, , 68 (4 ) ,2069-76

Retallack, D M; Deepe, G S; Woods, J P (2000. ) Applying in vivo expression technology (IVET) to the fungal pathogen Histoplasma capsulatum.Microbial pathogenesis, , 28 (3 ) ,169-82 More Information

Deepe, G S; Romani, L; Calich, V L; Huffnagle, G; Arruda, C; Molinari-Madlum, E E; Perfect, J R (2000. ) Knockout mice as experimental models of virulence. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 38 Suppl 1 ,87-98

Deepe, G S; Gibbons, R; Woodward, E (1999. ) Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum. Journal of immunology (Baltimore, Md. : 1950), , 163 (9 ) ,4985-93

Fisher, K L; Deepe, G S; Woods, J P (1999. ) Histoplasma capsulatum strain variation in both H antigen production and beta-glucosidase activity and overexpression of HAG1 from a telomeric linear plasmid. Infection and immunity, , 67 (7 ) ,3312-6

Allendörfer, R; Brunner, G D; Deepe, G S (1999. ) Complex requirements for nascent and memory immunity in pulmonary histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), , 162 (12 ) ,7389-96

Zancopé-Oliveira, R M; Reiss, E; Lott, T J; Mayer, L W; Deepe, G S (1999. ) Molecular cloning, characterization, and expression of the M antigen of Histoplasma capsulatum. Infection and immunity, , 67 (4 ) ,1947-53

Retallack, D M; Heinecke, E L; Gibbons, R; Deepe, G S; Woods, J P (1999. ) The URA5 gene is necessary for histoplasma capsulatum growth during infection of mouse and human cells. Infection and immunity, , 67 (2 ) ,624-9

Allendoerfer, R; Deepe, G S (1998. ) Infection with Histoplasma capsulatum: Host-fungus interface. Revista iberoamericana de micología : órgano de la Asociación Española de Especialistas en Micología, , 15 (4 ) ,256-60

Gomez, F J; Cain, J A; Gibbons, R; Allendoerfer, R; Deepe, G S (1998. ) Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis.The Journal of clinical investigation, , 102 (5 ) ,984-95 More Information

Allendoerfer, R; Deepe, G S (1998. ) Blockade of endogenous TNF-alpha exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. Journal of immunology (Baltimore, Md. : 1950), , 160 (12 ) ,6072-82

Deepe, G S; Seder, R A Molecular and cellular determinants of immunity to Histoplasma capsulatum. Research in immunology, , 149 (4-5 ) ,397-406; discussion

Cain, J A; Deepe, G S (1998. ) Evolution of the primary immune response to Histoplasma capsulatum in murine lung. Infection and immunity, , 66 (4 ) ,1473-81

Mounts, A; Deepe, G S (1998. ) Simultaneous infection with Blastomyces dermatitidis and Cryptococcus neoformans. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 36 (1 ) ,47-50

Batanghari, J W; Deepe, G S; Di Cera, E; Goldman, W E (1998. ) Histoplasma acquisition of calcium and expression of CBP1 during intracellular parasitism. Molecular microbiology, , 27 (3 ) ,531-9

Dixon, D M; Casadevall, A; Klein, B; Mendoza, L; Travassos, L; Deepe, G S (1998. ) Development of vaccines and their use in the prevention of fungal infections. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 36 Suppl 1 ,57-67

Murphy, J W; Bistoni, F; Deepe, G S; Blackstock, R A; Buchanan, K; Ashman, R B; Romani, L; Mencacci, A; Cenci, E; Fè d'Ostiani, C; Del Sero, G; Calich, V L; Kashino, S S (1998. ) Type 1 and type 2 cytokines: from basic science to fungal infections. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 36 Suppl 1 ,109-18

Matthews, R C; Maresca, B; Burnie, J P; Cardona, A; Carratu, L; Conti, S; Deepe, G S; Florez, A M; Franceschelli, S; Garcia, E; Gargano, L S; Kobayashi, G S; McEwen, J G; Ortiz, B L; Oviedo, A M; Polonelli, L; Ponton, J; Restrepos, A; Storlazzi, A (1998. ) Stress proteins in fungal diseases. Medical mycology : official publication of the International Society for Human and Animal Mycology, , 36 Suppl 1 ,45-51

Healy, D P; Dansereau, R J; Dunn, A B; Clendening, C E; Mounts, A W; Deepe, G S (1997. ) Reduced tetracycline bioavailability caused by magnesium aluminum silicate in liquid formulations of bismuth subsalicylate. The Annals of pharmacotherapy, , 31 (12 ) ,1460-4

Deepe, G S (1997. ) Prospects for the development of fungal vaccines. Clinical microbiology reviews, , 10 (4 ) ,585-96

Allendoerfer, R; Deepe, G S (1997. ) Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice. Infection and immunity, , 65 (7 ) ,2564-9

Allendoerfer, R; Biovin, G P; Deepe, G S (1997. ) Modulation of immune responses in murine pulmonary histoplasmosis. The Journal of infectious diseases, , 175 (4 ) ,905-14

Allendoerfer, R; Maresca, B; Deepe, G S (1996. ) Cellular immune responses to recombinant heat shock protein 70 from Histoplasma capsulatum. Infection and immunity, , 64 (10 ) ,4123-8

Deepe, G S; Gibbons, R; Brunner, G D; Gomez, F J (1996. ) A protective domain of heat-shock protein 60 from Histoplasma capsulatum. The Journal of infectious diseases, , 174 (4 ) ,828-34

Deepe, G S; Durose, G G (1995. ) Immunobiological activity of recombinant H antigen from Histoplasma capsulatum. Infection and immunity, , 63 (8 ) ,3151-7

Gomez, F J; Allendoerfer, R; Deepe, G S (1995. ) Vaccination with recombinant heat shock protein 60 from Histoplasma capsulatum protects mice against pulmonary histoplasmosis. Infection and immunity, , 63 (7 ) ,2587-95

Newman, S L; Gootee, L; Brunner, G; Deepe, G S (1994. ) Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis.The Journal of clinical investigation, , 93 (4 ) ,1422-9 More Information

Deepe, G S (1994. ) Role of CD8+ T cells in host resistance to systemic infection with Histoplasma capsulatum in mice. Journal of immunology (Baltimore, Md. : 1950), , 152 (7 ) ,3491-500

Deepe, G S (1994. ) The immune response to Histoplasma capsulatum: unearthing its secrets. The Journal of laboratory and clinical medicine, , 123 (2 ) ,201-5

Allendoerfer, R; Magee, D M; Deepe, G S; Graybill, J R (1993. ) Transfer of protective immunity in murine histoplasmosis by a CD4+ T-cell clone. Infection and immunity, , 61 (2 ) ,714-8

Deepe, G S (1993. ) Histoplasma capsulatum and V beta a mice: cellular immune responses and susceptibility patterns. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, , 31 (3 ) ,181-8

Gomez, F J; Gomez, A M; Deepe, G S (1992. ) An 80-kilodalton antigen from Histoplasma capsulatum that has homology to heat shock protein 70 induces cell-mediated immune responses and protection in mice. Infection and immunity, , 60 (7 ) ,2565-71

Henderson, H M; Deepe, G S (1992. ) Recognition of Histoplasma capsulatum yeast-cell antigens by human lymphocytes and human T-cell clones. Journal of leukocyte biology, , 51 (5 ) ,432-6

Domer, J E; Murphy, J W; Deepe, G S; Franco, M (1992. ) Immunomodulation in the mycoses. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, , 30 Suppl 1 ,157-66

Gomez, F J; Gomez, A M; Deepe, G S (1991. ) Protective efficacy of a 62-kilodalton antigen, HIS-62, from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infection and immunity, , 59 (12 ) ,4459-64

Gómez, A M; Rhodes, J C; Deepe, G S (1991. ) Antigenicity and immunogenicity of an extract from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infection and immunity, , 59 (1 ) ,330-6

Deepe, G S; Bullock, W E (1990. ) Immunological aspects of fungal pathogenesis. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, , 9 (8 ) ,567-79

Deepe, G S; Brunner, G D (1990. ) Functional analysis of Histoplasma capsulatum-reactive T-cell hybridomas. Infection and immunity, , 58 (6 ) ,1538-44

Harris, J E; Deepe, G S (1989. ) Requirements for histoplasmin presentation by accessory cells to a Histoplasma capsulatum-reactive T-cell line. Journal of leukocyte biology, , 45 (2 ) ,105-13

Deepe, G S; Bullock, W E (1989. ) Correlative studies of blastogenic responses and interleukin 1 production by mononuclear cells from patients with zoopathogenic fungal infections. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, , 27 (3 ) ,159-68

Hagler, D N; Deepe, G S; Pogue, C L; Walzer, P D (1988. ) Blastogenic responses to Pneumocystis carinii among patients with human immunodeficiency (HIV) infection. Clinical and experimental immunology, , 74 (1 ) ,7-13

Deepe, G S (1988. ) Protective immunity in murine histoplasmosis: functional comparison of adoptively transferred T-cell clones and splenic T cells. Infection and immunity, , 56 (9 ) ,2350-5

Harris, J E; Deepe, G S (1988. ) Characterization of antigenic determinants in histoplasmin that stimulate Histoplasma capsulatum-reactive T cells in vitro. Infection and immunity, , 56 (9 ) ,2343-9

Gomez, A M; Bullock, W E; Taylor, C L; Deepe, G S (1988. ) Role of L3T4+ T cells in host defense against Histoplasma capsulatum. Infection and immunity, , 56 (7 ) ,1685-91

Deepe, G S; Smith, J G; Sonnenfeld, G; Denman, D; Bullock, W E (1986. ) Development and characterization of Histoplasma capsulatum-reactive murine T-cell lines and clones. Infection and immunity, , 54 (3 ) ,714-22

Deepe, G S; Taylor, C L; Harris, J E; Bullock, W E (1986. ) Modulation of cellular immune responses in mice with disseminated histoplasmosis by recombinant interleukin-2. Infection and immunity, , 53 (1 ) ,6-12

Deepe, G S; Taylor, C L; Bullock, W E (1985. ) Evolution of inflammatory response and cellular immune responses in a murine model of disseminated blastomycosis. Infection and immunity, , 50 (1 ) ,183-9

Deepe, G S; Taylor, C L; Srivastava, L; Bullock, W E (1985. ) Impairment of granulomatous inflammatory response to Histoplasma capsulatum by inhibitors of angiotensin-converting enzyme. Infection and immunity, , 48 (2 ) ,395-401

Deepe, G S; Watson, S R; Bullock, W E (1984. ) Cellular origins and target cells of immunoregulatory factors in mice with disseminated histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), , 132 (4 ) ,2064-71

Bullock, W E; Deepe, G S (1983. ) Medical mycology in crisis. The Journal of laboratory and clinical medicine, , 102 (5 ) ,685-93

Deepe, G S; Kravitz, G R; Bullock, W E (1983. ) Pharmacological modulation of suppressor cell activity in mice with disseminated histoplasmosis. Infection and immunity, , 41 (1 ) ,114-20

Deepe, G S; MacMillan, B G; Linnemann, C C (1982. ) Unexplained fever in burn patients due to cytomegalovirus infection. JAMA : the journal of the American Medical Association, , 248 (18 ) ,2299-301

Deepe, G S; Watson, S R; Bullock, W E (1982. ) Generation of disparate immunoregulatory factors in two inbred strains of mice with disseminated histoplasmosis. Journal of immunology (Baltimore, Md. : 1950), , 129 (5 ) ,2186-91

Deepe, G S; Capparell, R; Coonrod, J D (1980. ) Atypical mycobacterial lymphadenitis in an adult. Chest, , 78 (6 ) ,882-3

Deepe, G S; Coonrod, J D (1980. ) Fulminant wound infection with Aeromonas hydrophila. Southern medical journal, , 73 (11 ) ,1546-7

Deepe, G S; Eagleton, L E (1980. ) Resolution of influenzal pneumonia. IMJ. Illinois medical journal, , 158 (2 ) ,76-8

Deepe, George S (2012. ) NADPH oxidase regulates efficacy of vaccination in aspergillosis.The Journal of clinical investigation, , 122 (5 ) ,1608-11 More Information

Kroetz, Danielle N; Deepe, George S (2012. ) The role of cytokines and chemokines in Histoplasma capsulatum infection.Cytokine, , 58 (1 ) ,112-7 More Information

Kroetz, Danielle N; Deepe, George S (2012. ) CCR5 deficiency mitigates the deleterious effects of tumor necrosis factor ? antagonism in murine histoplasmosis.The Journal of infectious diseases, , 205 (6 ) ,955-63 More Information

Wüthrich, Marcel; Deepe, George S; Klein, Bruce (2012. ) Adaptive immunity to fungi.Annual review of immunology, , 30 ,115-48 More Information

Deepe, George S; Buesing, William R (2012. ) Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection.Journal of immunology (Baltimore, Md. : 1950), , 188 (1 ) ,334-44 More Information

Figueroa, Julio A Landero; Vignesh, Kavitha Subramanian; Deepe, George S; Caruso, Joseph (2014. ) Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells.Metallomics : integrated biometal science, , 6 (2 ) ,301-15 More Information

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S (2013. ) Zinc sequestration: arming phagocyte defense against fungal attack.PLoS pathogens, , 9 (12 ) ,e1003815 More Information

Cole, Garry T; Hung, Chiung-Yu; Sanderson, Sam D; Hurtgen, Brady J; Wüthrich, Marcel; Klein, Bruce S; Deepe, George S; Ostroff, Gary R; Levitz, Stuart M (2013. ) Novel strategies to enhance vaccine immunity against coccidioidomycosis.PLoS pathogens, , 9 (12 ) ,e1003768 More Information

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S (2013. ) Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival.Immunity, , 39 (4 ) ,697-710 More Information

Rossi, S J; Healy, D P; Savani, D V; Deepe, G (1993. ) High-dose ciprofloxacin in the treatment of a renal cyst infection. The Annals of pharmacotherapy, , 27 (1 ) ,38-9

Verma, Akash; Wüthrich, Marcel; Deepe, George; Klein, Bruce (2014. ) Adaptive Immunity to Fungi.Cold Spring Harbor perspectives in medicine, , More Information

Verma, A; Kroetz, D N; Tweedle, J L; Deepe, G S (2014. ) Type II cytokines impair host defense against an intracellular fungal pathogen by amplifying macrophage generation of IL-33.Mucosal immunology, , More Information

Friedrich, Dirk; Fecher, Roger A; Rupp, Jan; Deepe, George S (2017. ) Impact of HIF-1? and hypoxia on fungal growth characteristics and fungal immunity.Microbes and infection, , 19 (3 ) ,204-209 More Information

Subramanian Vignesh, Kavitha; Deepe, George S (2016. ) Immunological orchestration of zinc homeostasis: The battle between host mechanisms and pathogen defenses.Archives of biochemistry and biophysics, , 611 ,66-78 More Information

Dade, Jessica; DuBois, Juwen C; Pasula, Rajamouli; Donnell, Anna M; Caruso, Joseph A; Smulian, A George; Deepe, George S (2016. ) HcZrt2, a zinc responsive gene, is indispensable for the survival of Histoplasma capsulatum in vivo.Medical mycology, , 54 (8 ) ,865-75 More Information

Huaman, Moises A; Deepe, George S; Fichtenbaum, Carl J Elevated Circulating Concentrations of Interferon-Gamma in Latent Tuberculosis Infection.Pathogens & immunity, , 1 (2 ) ,291-303 More Information

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Divanovic, Senad; Caruso, Joseph A; Deepe, George S (2016. ) IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages.Cell reports, , 16 (12 ) ,3232-46 More Information

George, Mariam Mathew; Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Caruso, Joseph A; Deepe, George S (2016. ) Zinc Induces Dendritic Cell Tolerogenic Phenotype and Skews Regulatory T Cell-Th17 Balance.Journal of immunology (Baltimore, Md. : 1950), , 197 (5 ) ,1864-76 More Information

Hsieh, Heidi; Vignesh, Kavitha Subramanian; Deepe, George S; Choubey, Divaker; Shertzer, Howard G; Genter, Mary Beth (2016. ) Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora.Toxicology in vitro : an international journal published in association with BIBRA, , 35 ,24-30 More Information

Fecher, Roger A; Horwath, Michael C; Friedrich, Dirk; Rupp, Jan; Deepe, George S (2016. ) Inverse Correlation between IL-10 and HIF-1? in Macrophages Infected with Histoplasma capsulatum.Journal of immunology (Baltimore, Md. : 1950), , 197 (2 ) ,565-79 More Information

Xiong, Ye; Lingrel, Jerry B; Wüthrich, Marcel; Klein, Bruce S; Vasudevan, Neelakantan T; Jain, Mukesh K; George, Mariam; Deepe, George S (2016. ) Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1?/Jagged2/Notch Axis.mBio, , 7 (3 ) , More Information

Sterkel, Alana K; Lorenzini, Jenna L; Fites, J Scott; Subramanian Vignesh, Kavitha; Sullivan, Thomas D; Wuthrich, Marcel; Brandhorst, Tristan; Hernandez-Santos, Nydiaris; Deepe, George S; Klein, Bruce S (2016. ) Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity.Cell host & microbe, , 19 (3 ) ,361-74 More Information

Horwath, Michael C; Fecher, Roger A; Deepe, George S (2015. ) Histoplasma capsulatum, lung infection and immunity.Future microbiology, , 10 (6 ) ,967-75 More Information

Donnell, Anna M; Lewis, Stephanie; Abraham, Sami; Subramanian, Kavitha; Figueroa, Julio Landero; Deepe, George S; Vonderheide, Anne P (2017. ) Investigation of an optimal cell lysis method for the study of the zinc metalloproteome of Histoplasma capsulatum.Analytical and bioanalytical chemistry, , More Information

Horwath, Michael C; Bell-Horwath, Tiffany R; Lescano, Victor; Krishnan, Karthik; Merino, Edward J; Deepe, George S (2017. ) Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1.Chembiochem : a European journal of chemical biology, , More Information

Bueter, Chelsea L; Deepe, George S (2018. ) Aeroallergens Exacerbate Histoplasma capsulatum Infection.Journal of immunology (Baltimore, Md. : 1950), , 201 (11 ) ,3352-3361 More Information

Deepe, George S (2018. ) Outbreaks of histoplasmosis: The spores set sail.PLoS pathogens, , 14 (9 ) ,e1007213 More Information

Kyrmizi, Irene; Ferreira, Helena; Carvalho, Agostinho; Figueroa, Julio Alberto Landero; Zarmpas, Pavlos; Cunha, Cristina; Akoumianaki, Tonia; Stylianou, Kostas; Deepe, George S; Samonis, George; Lacerda, João F; Campos, António; Kontoyiannis, Dimitrios P; Mihalopoulos, Nikolaos; Kwon-Chung, Kyung J; El-Benna, Jamel; Valsecchi, Isabel; Beauvais, Anne; Brakhage, Axel A; Neves, Nuno M; Latge, Jean-Paul; Chamilos, Georgios (2018. ) Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis.Nature microbiology, , 3 (7 ) ,791-803 More Information

Deepe, George S; Buesing, William R; Ostroff, Gary R; Abraham, Ambily; Specht, Charles A; Huang, Haibin; Levitz, Stuart M (2018. ) Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice.Vaccine, , 36 (23 ) ,3359-3367 More Information

Tweedle, Jamie L; Deepe, George S (2018. ) Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection.Infection and immunity, , 86 (6 ) , More Information

Subramanian Vignesh, Kavitha; Deepe, George S (2017. ) Metallothioneins: Emerging Modulators in Immunity and Infection.International journal of molecular sciences, , 18 (10 ) , More Information

Friedrich, Dirk; Zapf, Dorinja; Lohse, Björn; Fecher, Roger A; Deepe, George S; Rupp, Jan (2019. ) The HIF-1?/LC3-II-axis impacts on fungal immunity in human macrophages.Infection and immunity, , More Information

Honors and Awards

Graduated cum laude from Kenyon College

1981 -1983 Dalldorf Fellowship in Medical Mycology

1987 -1989 Research Career Development Award from NIAID

1999 Alpha Omega Alpha

1997 -2007 M.E.R.I.T. Award from NIAID

Keywords

Clinician,Investigator, Physician,Immunoregulation,Immune Response Mechanism,Infectious Diseases,Mycologist

Contact Information

Academic - Medical Sciences Building
Room 6152
Cincinnati  Ohio, 45267-0560
Phone: 513-558-4704
Fax: 513-558-2089
george.deepe@uc.edu