Sandra J Degen , PhD

Sandra Degen, PhD, interim chair of Molecular Genetics, Biochemistry & Microbiology in the College of Medicine at the University of Cincinnati, is also a professor of pediatrics and associate chair for academic affairs in the UC College of Medicine’s Department of Pediatrics and Cincinnati Children’s Hospital.

After receiving a PhD in biochemistry from the University of Washington, Dr. Degen completed two years of postdoctoral work at the Friedrich Miescher Institute, Basel, Switzerland. She joined the faculty and staff of the College of Medicine and Cincinnati Children's Research Foundation in 1985. Dr. Degen's scientific interests include the biological function of the blood coagulation agent prothrombin, as well as a protein identified in her lab that is involved in growth control. She enjoyed continuous grant support since she received her first academic position until 2006. Degen holds three patents for her discoveries. In addition to continuous NIH support for her research until 2006, Dr. Degen has been awarded $4M in grant and endowment support since 1997 from the Charlotte R. Schmidlapp Foundation to support the Center for Career Development of Women in Pediatrics.

Her many honors include being chosen as a Pew Scholar in the Biomedical Sciences, awarded an Established Investigatorship from the American Heart Association, membership of the Hematology II Study Section at the National Institutes of Health, and participation in the Executive Leadership in Academic Medicine Program. She was also awarded the 2005 Special Recognition Award in Thrombosis from the American Heart Association, elected as a Fellow of the American Association for the Advancement of Science (AAAS) in 2011 and elected as a Charter Fellow of the National Academy of Inventors in 2012.  Dr. Degen currently serves on the board of directors for the Cincinnati Youth Collaborative. Degen was appointed by the Governor of Ohio to the Third Frontier Advisory Board from 2009-2011. 

Dr. Degen has had several administrative roles within the university, including Associate Senior Vice President for Health Affairs (200-2004) and Vice President for Research (2004-2011).

 

Bachelor's Degree: University of California - San Diego and La Jolla San Diego, CA, and La Jolla, CA, 1976 (Chemistry with an emphasis in Biochemistry)

Doctoral Degree: University of Washington Seattle, WA, 1982 (Biochemistry)

Molecular biology of blood coagulation proteins and structurally related proteins, including hepatocyte-growth factor-like protein (HGFL).

1983 -1985 Postdoctoral Fellow, Friedrich Meisher Institute, Basel, Switzerland

1985 -1992 Assistant Professor, University of Cincinnati & Cincinnati Children's Hospital, Cincinnati, OH

1992 -1997 Associate Professor with tenure, University of Cincinnati and Cincinnati Children's Hospital, Cincinnati, OH

1997 - Professor, University of Cincinnati and Cincinnati Children's Hospital, Cincinnati, OH

1993 -1995 Director of Graduate Studies, Graduate Program in Developmental Biology, University of Cincinnati and Cincinnati Children's Hospital, Cincinnati, OH

1995 -1998 Director, Graduate Program in Developmental Biology, University of Cincinnati and Cincinnati Children's Hospital, Cincinnati, OH

1998 - Associate Chair for Academic Affairs, Dept of Pediatrics, University of Cincinnati and Cincinnati Children's Hospital, Cincinnati, OH

2000 -2007 Associate Sr Vice President for Health Affairs, University of Cincinnati and Cincinnati Children's Hospital, Cincinnati, OH

2004 -2011 Vice President for Research, University of Cincinnati, Cincinnati, OH

2011 - Interim Chair, Dept of Molecular Genetics, Biochemistry & Microbiology, University of Cincinnati, Cincinnati, OH

Investigators:Sandra J. Degen, PI 1997 -To Present Charlotte R. Schmidlapp Trust/Fifth Third Bank Center for Career Development of Women in Academic Pediatrics Role:PI $4,000,000 Active Type:Grant

Investigators:Santa Ono, PhD and Melanie Cushion, PhD = PIs 2012 -2017 NSF ADVANCE grant: Leadership, Empowerment, Advancement for Women in STEM Faculty (LEAF) Role:Leadership Team member $3,749,337 Active Type:Grant

Grant: #0 Investigators:Degen, Sandra 11-01-2005 -10-31-2007 Howard Hughes Medical Institute BWF-HHMI Partners in Scientific Management Program Role:PI $1,000.00 Closed Level:Private Non-Profit

Grant: #CHMC-20-09-A0-S0-E0 Investigators:Degen, Sandra 07-01-1997 -06-30-2000 Cincinnati Children's Hospital Medical Center Developmental Biology Program Role:PI $934,000.00 Closed Level:Private Non-Profit

Grant: #MEDTAPP Project 3 Investigators:Degen, Sandra; Lannon, Carole 10-01-2008 -06-30-2011 Centers for Medicare & Medicaid Services Center of Excellence for Improving Child Health Outcomes Role:PI $156,854.00 Closed Level:Federal

Grant: #MEDTAPP Inform Future Policy Choices Investigators:Degen, Sandra; Fairbrother, Gerry; Simpson, Lisa 10-01-2008 -06-30-2011 Centers for Medicare & Medicaid Services Research to Evaluate the Ohio Medicaid Expansion and Inform Future Policy Choices Role:PI $584,536.00 Closed Level:Federal

Grant: #MEDTAPP Obesity Prevention Investigators:Degen, Sandra; Lannon, Carole 01-12-2009 -06-30-2011 Centers for Medicare & Medicaid Services Center of Excellence in Child Healthcare- a University - Practice - Public Partnership - Project 4: Preventing Childhood Obesity Role:PI $300,000.00 Closed Level:Federal

Grant: #PO RF01149532 Investigators:Degen, Sandra; Mitchell, Monica 10-01-2008 -06-30-2009 Centers for Medicare & Medicaid Services Mental Health Status, Access and Service Utilization in Ohio: Trends Related to Insurance, Income, Demographic Characteristics and Physical Health Role:PI $34,500.00 Closed Level:Federal

Grant: #1008496 Investigators:Degen, Sandra; Ware, Stephanie 07-01-2009 -06-30-2015 Burroughs Wellcome Fund Uncovering Novel Genetic Causes and Risks in Congenital Heart Disease Patients Role:PI $750,000.00 Active Level:Private Non-Profit

Grant: #C1011-07-0166 Investigators:Degen, Sandra; Donovan, Edward 07-01-2009 -06-30-2010 Centers for Medicare & Medicaid Services CMS Neonatal Outcomes Improvement Project Role:PI $621,651.00 Closed Level:Federal

Grant: #SRS 006493 Investigators:Degen, Sandra; Lannon, Carole 07-01-2009 -06-30-2011 Centers for Medicare & Medicaid Services Project 3 Structured Development Assessment Appropriate Referral and Treatment Role:PI $348,061.00 Closed Level:Federal

Grant: #1 G20 RR030832-01 Investigators:Ball, William; Braswell, Gregory; Degen, Sandra; Stone, Douglas 03-04-2010 -09-30-2013 National Center for Research Resources Renovation for Safety and Long-Term Support of Rodent Research at University of Cincinnati Role:Collaborator $8,439,998.00 Active Level:Federal

Grant: #BR-5060 Investigators:Ball, William; Chuang, Chiou-fen; Degen, Sandra 09-15-2010 -09-15-2014 Alfred P. Sloan Foundation Dr. Chuang Sloan Foundation Fellowship Role:Collaborator $50,000.00 Active Level:Private Non-Profit

Grant: #UN10-004262 Investigators:Degen, Sandra 07-01-2010 -06-30-2011 Greater Cincinnati Foundation Grant Writing Assistance for the DOE Application Role:PI $10,000.00 Closed Level:Private Non-Profit

Grant: #CHE-0962996 Investigators:Degen, Sandra; Limbach, Patrick 09-15-2010 -08-31-2013 National Science Foundation Renovation of Chemistry Facilities at the University of Cincinnati Role:Collaborator $1,200,000.00 Active Level:Federal

Grant: #HRD-1209169 Investigators:Cushion, Melanie; Degen, Sandra; Ghia, Urmila; Hardcastle, Valerie; Holloway, Stacie; Howe, Steven; Kallen, Rachel; Ono, Santa 09-15-2012 -08-31-2017 National Science Foundation Leadership, Empowerment, and Advancement for STEM Women Faculty (LEAF) at UC Role:Collaborator $738,310.00 Active Level:Federal

Grant: #HRD-1209169 Investigators:Cushion, Melanie; Degen, Sandra; Ghia, Urmila; Hardcastle, Valerie; Holloway, Stacie; Howe, Steven; Kallen, Rachel; Ono, Santa 09-15-2012 -08-31-2017 National Science Foundation Leadership, Empowerment, and Advancement for STEM Women Faculty (LEAF) at UC Role:Collaborator $1,468,854.00 Active Level:Federal

Peer Reviewed Publications

MacGillivray,R.T.; Degen,S.J.; Chandra,T.; Woo,S.L.; Davie,E.W. (1980. ) Cloning and analysis of a cDNA coding for bovine prothrombin .Proceedings of the National Academy of Sciences of the United States of America, , 77 (9 ) ,5153 -5157

Kurachi,K.; Chandra,T.; Degen,S.J.; White,T.T.; Marchioro,T.L.; Woo,S.L.; Davie,E.W. (1981. ) Cloning and sequence of cDNA coding for alpha 1-antitrypsin .Proceedings of the National Academy of Sciences of the United States of America, , 78 (11 ) ,6826 -6830

Degen,S.J.; MacGillivray,R.T.; Davie,E.W. (1983. ) Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin .Biochemistry, , 22 (9 ) ,2087 -2097

Degen,J.L.; Neubauer,M.G.; Degen,S.J.; Seyfried,C.E.; Morris,D.R. (1983. ) Regulation of protein synthesis in mitogen-activated bovine lymphocytes. Analysis of actin-specific and total mRNA accumulation and utilization .The Journal of biological chemistry, , 258 (20 ) ,12153 -12162

Degen,S.J.; Rajput,B.; Reich,E. (1986. ) The human tissue plasminogen activator gene .The Journal of biological chemistry, , 261 (15 ) ,6972 -6985

Degen,S.J.; Davie,E.W. (1986. ) The prothrombin gene and serine proteinase evolution .Annals of the New York Academy of Sciences, , 485 ,66 -72

Degen,S.J.; Davie,E.W. (1987. ) Nucleotide sequence of the gene for human prothrombin .Biochemistry, , 26 (19 ) ,6165 -6177

Degen,S.J.; Heckel,J.L.; Reich,E.; Degen,J.L. (1987. ) The murine urokinase-type plasminogen activator gene .Biochemistry, , 26 (25 ) ,8270 -8279

Bancroft,J.D.; Schaefer,L.A.; Degen,S.J. (1990. ) Characterization of the Alu-rich 5'-flanking region of the human prothrombin-encoding gene: identification of a positive cis-acting element that regulates liver-specific expression .Gene, , 95 (2 ) ,253 -260

Degen,S.J.; Bell,S.M.; Schaefer,L.A.; Elliott,R.W. (1990. ) Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17 .Genomics, , 8 (1 ) ,49 -61

Degen,S.J.; Schaefer,L.A.; Jamison,C.S.; Grant,S.G.; Fitzgibbon,J.J.; Pai,J.A.; Chapman,V.M.; Elliott,R.W. (1990. ) Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2 .DNA and cell biology, , 9 (7 ) ,487 -498

Han,S.; Stuart,L.A.; Degen,S.J. (1991. ) Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor .Biochemistry, , 30 (40 ) ,9768 -9780

Degen,S.J.; Stuart,L.A.; Han,S.; Jamison,C.S. (1991. ) Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development .Biochemistry, , 30 (40 ) ,9781 -9791

Dichek,D.A.; Nussbaum,O.; Degen,S.J.; Anderson,W.F. (1991. ) Enhancement of the fibrinolytic activity of sheep endothelial cells by retroviral vector-mediated gene transfer .Blood, , 77 (3 ) ,533 -541

Jamison,C.S.; Degen,S.J. (1991. ) Prenatal and postnatal expression of mRNA coding for rat prothrombin .Biochimica et biophysica acta, , 1088 (2 ) ,208 -216

Degen,S.J.; Gilbert,D.J.; Jenkins,N.A.; Copeland,N.G. (1992. ) Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9 .Genomics, , 13 (4 ) ,1368 -1369

Jamison,C.S.; Degen,S.J. (1992. ) Non-specific effects of aquaMEPHYTON (vitamin K1) on prothrombin expression in human hepatoblastoma (HepG2) cells .Thrombosis research, , 65 (3 ) ,409 -419

Jamison,C.S.; Burkey,B.F.; Degen,S.J. (1992. ) The effects of vitamin K1 and warfarin on prothrombin expression in human hepatoblastoma (HepG2) cells .Thrombosis and haemostasis, , 68 (1 ) ,40 -47

Bancroft,J.D.; McDowell,S.A.; Degen,S.J. (1992. ) The human prothrombin gene: transcriptional regulation in HepG2 cells .Biochemistry, , 31 (49 ) ,12469 -12476

Degen,S.J. (1992. ) The prothrombin gene and its liver-specific expression .Seminars in thrombosis and hemostasis, , 18 (2 ) ,230 -242

Bezerra,J.A.; Han,S.; Danton,M.J.; Degen,S.J. (1993. ) Are hepatocyte growth factor-like protein and macrophage stimulating protein the same protein? .Protein science : a publication of the Protein Society, , 2 (4 ) ,666 -668

Han,S.; Degen,S.J. (1993. ) Genomic organization, chromosomal localization and developmental expression of hepatocyte growth factor-like protein .EXS, , 65 ,81 -105

Bezerra,J.A.; Witte,D.P.; Aronow,B.J.; Degen,S.J. (1993. ) Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein .Hepatology (Baltimore, Md.), , 18 (2 ) ,394 -399

Sites,C.K.; Patterson,K.; Jamison,C.S.; Degen,S.J.; LaBarbera,A.R. (1994. ) Follicle-stimulating hormone (FSH) increases FSH receptor messenger ribonucleic acid while decreasing FSH binding in cultured porcine granulosa cells .Endocrinology, , 134 (1 ) ,411 -417

Harrison,P.; Degen,S.J.; Williams,R.; Farzaneh,F. (1994. ) Hepatic expression of hepatocyte-growth-factor-like/macrophage-stimulating protein mRNA in fulminant hepatic failure .Lancet, , 344 (8914 ) ,27 -29

Bezerra,J.A.; Laney,D.W.,Jr; Degen,S.J. (1994. ) Increased expression of mRNA for hepatocyte growth factor-like protein during liver regeneration and inflammation .Biochemical and biophysical research communications, , 203 (1 ) ,666 -673

Laney,D.W.,Jr; Bezerra,J.A.; Kosiba,J.L.; Degen,S.J.; Cohen,M.B. (1994. ) Upregulation of Escherichia coli heat-stable enterotoxin receptor in regenerating rat liver .The American Journal of Physiology, , 266 (5 Pt 1 ) ,G899 -906

Jamison,C.S.; McDowell,S.A.; Marlar,R.A.; Degen,S.J. (1995. ) Developmental expression of protein C and protein S in the rat .Thrombosis research, , 78 (5 ) ,407 -419

Degen,S.J.; McDowell,S.A.; Sparks,L.M.; Scharrer,I. (1995. ) Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala .Thrombosis and haemostasis, , 73 (2 ) ,203 -209

Waltz,S.E.; Gould,F.K.; Air,E.L.; McDowell,S.A.; Degen,S.J. (1996. ) Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein .The Journal of biological chemistry, , 271 (15 ) ,9024 -9032

Waltz,S.E.; McDowell,S.A.; Muraoka,R.S.; Air,E.L.; Flick,L.M.; Chen,Y.Q.; Wang,M.H.; Degen,S.J. (1997. ) Functional characterization of domains contained in hepatocyte growth factor-like protein .The Journal of biological chemistry, , 272 (48 ) ,30526 -30537

Bezerra,J.A.; Carrick,T.L.; Degen,J.L.; Witte,D.; Degen,S.J. (1998. ) Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice .The Journal of clinical investigation, , 101 (5 ) ,1175 -1183

Waltz,S.E.; Toms,C.L.; McDowell,S.A.; Clay,L.A.; Muraoka,R.S.; Air,E.L.; Sun,W.Y.; Thomas,M.B.; Degen,S.J. (1998. ) Characterization of the mouse Ron/Stk receptor tyrosine kinase gene .Oncogene, , 16 (1 ) ,27 -42

Sun,W.Y.; Witte,D.P.; Degen,J.L.; Colbert,M.C.; Burkart,M.C.; Holmback,K.; Xiao,Q.; Bugge,T.H.; Degen,S.J. (1998. ) Prothrombin deficiency results in embryonic and neonatal lethality in mice .Proceedings of the National Academy of Sciences of the United States of America, , 95 (13 ) ,7597 -7602

Degen,S.J.; McDowell,S.A.; Waltz,S.E.; Gould,F.; Stuart,L.A.; Carritt,B. (1998. ) Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein .DNA sequence : the journal of DNA sequencing and mapping, , 8 (6 ) ,409 -413

Degen,S.J.; Sun,W.Y. (1998. ) The biology of prothrombin .Critical reviews in eukaryotic gene expression, , 8 (2 ) ,203 -224

Muraoka,R.S.; Waltz,S.E.; Degen,S.J. (1999. ) Expression of hepatocyte growth factor-like protein is repressed by retinoic acid and enhanced by cyclic adenosine 3',5'-monophosphate response element-binding protein (CREB)-binding protein (CBP) .Endocrinology, , 140 (1 ) ,187 -196

Sun,W.Y.; Ruiz-Saez,A.; Burkart,M.C.; Bosch,N.; Degen,S.J. (1999. ) Prothrombin carora: hypoprothrombinaemia caused by substitution of Tyr-44 by Cys .British journal of haematology, , 105 (3 ) ,670 -672

Hsung,R.P.; Shen,H.C.; Douglas,C.J.; Morgan,C.D.; Degen,S.J.; Yao,L.J. (1999. ) Sequential 1,2-Addition-Electrocyclic Ring Closures Involving Acyclic alpha,beta-Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles .The Journal of organic chemistry, , 64 (3 ) ,690 -691

Degen,S.J.; Mueller,K.L.; Shen,H.C.; Mulder,J.A.; Golding,G.M.; Wei,L.L.; Zificsak,C.A.; Neeno-Eckwall,A.; Hsung,R.P. (1999. ) Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin .Bioorganic & medicinal chemistry letters, , 9 (7 ) ,973 -978

Sklenicka,H.M.; Hsung,R.P.; Wei,L.L.; McLaughlin,M.J.; Gerasyuto,A.I.; Degen,S.J. (2000. ) Highly stereoselective formal .Organic letters, , 2 (8 ) ,1161 -1164

Sun,W.Y.; Burkart,M.C.; Holahan,J.R.; Degen,S.J. (2000. ) Prothrombin San Antonio: a single amino acid substitution at a factor Xa activation site (Arg320 to His) results in dysprothrombinemia .Blood, , 95 (2 ) ,711 -714

Sun,W.Y.; Degen,S.J. (2001. ) Gene targeting in hemostasis. Prothrombin .Frontiers in bioscience : a journal and virtual library, , 6 ,D222 -38

Peace,B.E.; Hughes,M.J.; Degen,S.J.; Waltz,S.E. (2001. ) Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis .Oncogene, , 20 (43 ) ,6142 -6151

Sun,W.Y.; Smirnow,D.; Jenkins,M.L.; Degen,S.J. (2001. ) Prothrombin Scranton: substitution of an amino acid residue involved in the binding of Na+ (LYS-556 to THR) leads to dysprothrombinemia .Thrombosis and haemostasis, , 85 (4 ) ,651 -654

Waltz,S.E.; Eaton,L.; Toney-Earley,K.; Hess,K.A.; Peace,B.E.; Ihlendorf,J.R.; Wang,M.H.; Kaestner,K.H.; Degen,S.J. (2001. ) Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses .The Journal of clinical investigation, , 108 (4 ) ,567 -576

Leonis,M.A.; Toney-Earley,K.; Degen,S.J.; Waltz,S.E. (2002. ) Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure .Hepatology (Baltimore, Md.), , 36 (5 ) ,1053 -1060

Sun,W.Y.; Coleman,M.J.; Witte,D.P.; Degen,S.J. (2002. ) Rescue of prothrombin-deficiency by transgene expression in mice .Thrombosis and haemostasis, , 88 (6 ) ,984 -991

McDowell,S.A.; Mallakin,A.; Bachurski,C.J.; Toney-Earley,K.; Prows,D.R.; Bruno,T.; Kaestner,K.H.; Witte,D.P.; Melin-Aldana,H.; Degen,S.J.; Leikauf,G.D.; Waltz,S.E. (2002. ) The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury .American journal of respiratory cell and molecular biology, , 26 (1 ) ,99 -104

Wetzel,C.C.; Degen,S.J.; Waltz,S.E. (2003. ) Cis-acting elements in the hepatocyte growth factor-like protein gene regulate kidney and liver-specific expression in mice .DNA and cell biology, , 22 (5 ) ,293 -301

Peace,B.E.; Hill,K.J.; Degen,S.J.; Waltz,S.E. (2003. ) Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor .Experimental cell research, , 289 (2 ) ,317 -325

Hess,K.A.; Waltz,S.E.; Chan,E.L.; Degen,S.J. (2003. ) Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function .Biology of reproduction, , 68 (4 ) ,1267 -1275

Hess,K.A.; Waltz,S.E.; Toney-Earley,K.; Degen,S.J. (2003. ) The receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible nitric oxide synthase levels and ovulation .Fertility and sterility, , 80 Suppl 2 ,747 -754

Wu,J.; Wang,Y.; Xiao,W.; Meyer,K.B.; Schmidt,K.M.; Morris,R.E.; Degen,S.J.; La Barbera,A.R. (2004. ) Assessment of recombinant porcine follicle-stimulating hormone receptor using a novel polyclonal ectodomain antibody .Endocrine research, , 30 (2 ) ,269 -285

Kahn,J.A.; Degen,S.J.; Mansour,M.E.; Goodman,E.; Zeller,M.H.; Laor,T.; Lanphear,N.E.; Boat,T.F. (2005. ) Pediatric faculty members' attitudes about part-time faculty positions and policies to support part-time faculty: a study at one medical center .Academic medicine : journal of the Association of American Medical Colleges, , 80 (10 ) ,931 -939

Wetzel,C.C.; Leonis,M.A.; Dent,A.; Olson,M.A.; Longmeier,A.M.; Ney,P.A.; Boivin,G.P.; Kader,S.A.; Caldwell,C.C.; Degen,S.J.; Waltz,S.E. (2007. ) Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury .American journal of physiology.Gastrointestinal and liver physiology, , 292 (1 ) ,G253 -61

Mullins, Eric S; Kombrinck, Keith W; Talmage, Kathryn E; Shaw, Maureen A; Witte, David P; Ullman, Joni M; Degen, Sandra J; Sun, William; Flick, Matthew J; Degen, Jay L (2009. ) Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.Blood, , 113 (3 ) ,696-704 More Information

Wetzel, Cynthia C; Leonis, Mike A; Dent, Arlene; Olson, Meredith A; Longmeier, Angela M; Ney, Paul A; Boivin, Greg P; Kader, Sarah A; Caldwell, Charles C; Degen, Sandra J F; Waltz, Susan E (2007. ) Short-form Ron receptor is required for normal IFN-gamma production in concanavalin A-induced acute liver injury.American journal of physiology. Gastrointestinal and liver physiology, , 292 (1 ) ,G253-61 More Information

Kahn, Jessica A; Degen, Sandra J F; Mansour, Mona E; Goodman, Elizabeth; Zeller, Meg H; Laor, Tal; Lanphear, Nancy E; Boat, Thomas F (2005. ) Pediatric faculty members' attitudes about part-time faculty positions and policies to support part-time faculty: a study at one medical center. Academic medicine : journal of the Association of American Medical Colleges, , 80 (10 ) ,931-9

Wu, Jianqiang; Wang, Yifang; Xiao, Weihong; Meyer, Kevin B; Schmidt, Kara M; Morris, Randal E; Degen, Sandra J F; La Barbera, Andrew R (2004. ) Assessment of recombinant porcine follicle-stimulating hormone receptor using a novel polyclonal ectodomain antibody. Endocrine research, , 30 (2 ) ,269-85

Peace, Belinda E; Hill, Kara J; Degen, Sandra J F; Waltz, Susan E (2003. ) Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor. Experimental cell research, , 289 (2 ) ,317-25

Hess, Karla Ann; Waltz, Susan E; Toney-Earley, Kenya; Degen, Sandra J F (2003. ) The receptor tyrosine kinase Ron is expressed in the mouse ovary and regulates inducible nitric oxide synthase levels and ovulation. Fertility and sterility, , 80 Suppl 2 ,747-54

Wetzel, Cynthia C; Degen, Sandra J F; Waltz, Susan E (2003. ) Cis-acting elements in the hepatocyte growth factor-like protein gene regulate kidney and liver-specific expression in mice.DNA and cell biology, , 22 (5 ) ,293-301 More Information

Hess, Karla Ann; Waltz, Susan E; Chan, Edward L; Degen, Sandra J F (2003. ) Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.Biology of reproduction, , 68 (4 ) ,1267-75 More Information

Sun, William Y; Coleman, Mallory J; Witte, David P; Degen, Sandra J F (2002. ) Rescue of prothrombin-deficiency by transgene expression in mice.Thrombosis and haemostasis, , 88 (6 ) ,984-91 More Information

Leonis, Mike A; Toney-Earley, Kenya; Degen, Sandra J F; Waltz, Susan E (2002. ) Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure.Hepatology (Baltimore, Md.), , 36 (5 ) ,1053-60 More Information

McDowell, Susan A; Mallakin, Ali; Bachurski, Cindy J; Toney-Earley, Kenya; Prows, Daniel R; Bruno, Theresa; Kaestner, Klaus H; Witte, David P; Melin-Aldana, Hector; Degen, Sandra J F; Leikauf, George D; Waltz, Susan E (2002. ) The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury. American journal of respiratory cell and molecular biology, , 26 (1 ) ,99-104

Peace, B E; Hughes, M J; Degen, S J; Waltz, S E (2001. ) Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis.Oncogene, , 20 (43 ) ,6142-51 More Information

Waltz, S E; Eaton, L; Toney-Earley, K; Hess, K A; Peace, B E; Ihlendorf, J R; Wang, M H; Kaestner, K H; Degen, S J (2001. ) Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses.The Journal of clinical investigation, , 108 (4 ) ,567-76 More Information

Sun, W Y; Smirnow, D; Jenkins, M L; Degen, S J (2001. ) Prothrombin Scranton: substitution of an amino acid residue involved in the binding of Na+ (LYS-556 to THR) leads to dysprothrombinemia. Thrombosis and haemostasis, , 85 (4 ) ,651-4

Sun, W Y; Degen, S J (2001. ) Gene targeting in hemostasis. Prothrombin. Frontiers in bioscience : a journal and virtual library, , 6 ,D222-38

Sklenicka, ; Hsung, ; Wei, ; McLaughlin, ; Gerasyuto, ; Degen, (2000. ) Highly stereoselective formal .Organic letters, , 2 (8 ) ,1161-4

Sun, W Y; Burkart, M C; Holahan, J R; Degen, S J (2000. ) Prothrombin San Antonio: a single amino acid substitution at a factor Xa activation site (Arg320 to His) results in dysprothrombinemia. Blood, , 95 (2 ) ,711-4

Sun, W Y; Ruiz-Saez, A; Burkart, M C; Bosch, N; Degen, S J (1999. ) Prothrombin carora: hypoprothrombinaemia caused by substitution of Tyr-44 by Cys. British journal of haematology, , 105 (3 ) ,670-2

Degen, S J; Mueller, K L; Shen, H C; Mulder, J A; Golding, G M; Wei, L L; Zificsak, C A; Neeno-Eckwall, A; Hsung, R P (1999. ) Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin. Bioorganic & medicinal chemistry letters, , 9 (7 ) ,973-8

Hsung, Richard P.; Shen, Hong C.; Douglas, Christopher J.; Morgan, Christopher D.; Degen, Shane J.; Yao, Letitia J. (1999. ) Sequential 1,2-Addition-Electrocyclic Ring Closures Involving Acyclic alpha,beta-Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles. The Journal of organic chemistry, , 64 (3 ) ,690-691

Muraoka, R S; Waltz, S E; Degen, S J (1999. ) Expression of hepatocyte growth factor-like protein is repressed by retinoic acid and enhanced by cyclic adenosine 3',5'-monophosphate response element-binding protein (CREB)-binding protein (CBP). Endocrinology, , 140 (1 ) ,187-96

Sun, W Y; Witte, D P; Degen, J L; Colbert, M C; Burkart, M C; Holmbäck, K; Xiao, Q; Bugge, T H; Degen, S J (1998. ) Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proceedings of the National Academy of Sciences of the United States of America, , 95 (13 ) ,7597-602

Bezerra, J A; Carrick, T L; Degen, J L; Witte, D; Degen, S J (1998. ) Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.The Journal of clinical investigation, , 101 (5 ) ,1175-83 More Information

Waltz, S E; Toms, C L; McDowell, S A; Clay, L A; Muraoka, R S; Air, E L; Sun, W Y; Thomas, M B; Degen, S J (1998. ) Characterization of the mouse Ron/Stk receptor tyrosine kinase gene.Oncogene, , 16 (1 ) ,27-42 More Information

Degen, S J; Sun, W Y (1998. ) The biology of prothrombin. Critical reviews in eukaryotic gene expression, , 8 (2 ) ,203-24

Degen, S J; McDowell, S A; Waltz, S E; Gould, F; Stuart, L A; Carritt, B (1998. ) Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein. DNA sequence : the journal of DNA sequencing and mapping, , 8 (6 ) ,409-13

Waltz, S E; McDowell, S A; Muraoka, R S; Air, E L; Flick, L M; Chen, Y Q; Wang, M H; Degen, S J (1997. ) Functional characterization of domains contained in hepatocyte growth factor-like protein. The Journal of biological chemistry, , 272 (48 ) ,30526-37

Waltz, S E; Gould, F K; Air, E L; McDowell, S A; Degen, S J (1996. ) Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein. The Journal of biological chemistry, , 271 (15 ) ,9024-32

Jamison, C S; McDowell, S A; Marlar, R A; Degen, S J (1995. ) Developmental expression of protein C and protein S in the rat. Thrombosis research, , 78 (5 ) ,407-19

Degen, S J; McDowell, S A; Sparks, L M; Scharrer, I (1995. ) Prothrombin Frankfurt: a dysfunctional prothrombin characterized by substitution of Glu-466 by Ala. Thrombosis and haemostasis, , 73 (2 ) ,203-9

Bezerra, J A; Laney, D W; Degen, S J (1994. ) Increased expression of mRNA for hepatocyte growth factor-like protein during liver regeneration and inflammation.Biochemical and biophysical research communications, , 203 (1 ) ,666-73 More Information

Harrison, P; Degen, S J; Williams, R; Farzaneh, F (1994. ) Hepatic expression of hepatocyte-growth-factor-like/macrophage-stimulating protein mRNA in fulminant hepatic failure. Lancet, , 344 (8914 ) ,27-9

Laney, D W; Bezerra, J A; Kosiba, J L; Degen, S J; Cohen, M B (1994. ) Upregulation of Escherichia coli heat-stable enterotoxin receptor in regenerating rat liver. The American journal of physiology, , 266 (5 Pt 1 ) ,G899-906

Sites, C K; Patterson, K; Jamison, C S; Degen, S J; LaBarbera, A R (1994. ) Follicle-stimulating hormone (FSH) increases FSH receptor messenger ribonucleic acid while decreasing FSH binding in cultured porcine granulosa cells. Endocrinology, , 134 (1 ) ,411-7

Bezerra, J A; Witte, D P; Aronow, B J; Degen, S J (1993. ) Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein. Hepatology (Baltimore, Md.), , 18 (2 ) ,394-9

Bezerra, J A; Han, S; Danton, M J; Degen, S J (1993. ) Are hepatocyte growth factor-like protein and macrophage stimulating protein the same protein?.Protein science : a publication of the Protein Society, , 2 (4 ) ,666-8 More Information

Han, S; Degen, S J (1993. ) Genomic organization, chromosomal localization and developmental expression of hepatocyte growth factor-like protein. EXS, , 65 ,81-105

Bancroft, J D; McDowell, S A; Degen, S J (1992. ) The human prothrombin gene: transcriptional regulation in HepG2 cells. Biochemistry, , 31 (49 ) ,12469-76

Degen, S J; Gilbert, D J; Jenkins, N A; Copeland, N G (1992. ) Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9. Genomics, , 13 (4 ) ,1368-9

Jamison, C S; Burkey, B F; Degen, S J (1992. ) The effects of vitamin K1 and warfarin on prothrombin expression in human hepatoblastoma (HepG2) cells. Thrombosis and haemostasis, , 68 (1 ) ,40-7

Jamison, C S; Degen, S J (1992. ) Non-specific effects of aquaMEPHYTON (vitamin K1) on prothrombin expression in human hepatoblastoma (HepG2) cells. Thrombosis research, , 65 (3 ) ,409-19

Degen, S J (1992. ) The prothrombin gene and its liver-specific expression. Seminars in thrombosis and hemostasis, , 18 (2 ) ,230-42

Degen, S J; Stuart, L A; Han, S; Jamison, C S (1991. ) Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Biochemistry, , 30 (40 ) ,9781-91

Han, S; Stuart, L A; Degen, S J (1991. ) Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry, , 30 (40 ) ,9768-80

Jamison, C S; Degen, S J (1991. ) Prenatal and postnatal expression of mRNA coding for rat prothrombin. Biochimica et biophysica acta, , 1088 (2 ) ,208-16

Dichek, D A; Nussbaum, O; Degen, S J; Anderson, W F (1991. ) Enhancement of the fibrinolytic activity of sheep endothelial cells by retroviral vector-mediated gene transfer. Blood, , 77 (3 ) ,533-41

Bancroft, J D; Schaefer, L A; Degen, S J (1990. ) Characterization of the Alu-rich 5'-flanking region of the human prothrombin-encoding gene: identification of a positive cis-acting element that regulates liver-specific expression. Gene, , 95 (2 ) ,253-60

Degen, S J; Schaefer, L A; Jamison, C S; Grant, S G; Fitzgibbon, J J; Pai, J A; Chapman, V M; Elliott, R W (1990. ) Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2. DNA and cell biology, , 9 (7 ) ,487-98

Degen, S J; Bell, S M; Schaefer, L A; Elliott, R W (1990. ) Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17. Genomics, , 8 (1 ) ,49-61

Degen, S J; Heckel, J L; Reich, E; Degen, J L (1987. ) The murine urokinase-type plasminogen activator gene. Biochemistry, , 26 (25 ) ,8270-9

Degen, S J; Davie, E W (1987. ) Nucleotide sequence of the gene for human prothrombin. Biochemistry, , 26 (19 ) ,6165-77

Degen, S J; Rajput, B; Reich, E (1986. ) The human tissue plasminogen activator gene. The Journal of biological chemistry, , 261 (15 ) ,6972-85

Degen, S J; Davie, E W (1986. ) The prothrombin gene and serine proteinase evolution. Annals of the New York Academy of Sciences, , 485 ,66-72

Degen, J L; Neubauer, M G; Degen, S J; Seyfried, C E; Morris, D R (1983. ) Regulation of protein synthesis in mitogen-activated bovine lymphocytes. Analysis of actin-specific and total mRNA accumulation and utilization. The Journal of biological chemistry, , 258 (20 ) ,12153-62

Degen, S J; MacGillivray, R T; Davie, E W (1983. ) Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin. Biochemistry, , 22 (9 ) ,2087-97

Kurachi, K; Chandra, T; Degen, S J; White, T T; Marchioro, T L; Woo, S L; Davie, E W (1981. ) Cloning and sequence of cDNA coding for alpha 1-antitrypsin. Proceedings of the National Academy of Sciences of the United States of America, , 78 (11 ) ,6826-30

MacGillivray, R T; Degen, S J; Chandra, T; Woo, S L; Davie, E W (1980. ) Cloning and analysis of a cDNA coding for bovine prothrombin. Proceedings of the National Academy of Sciences of the United States of America, , 77 (9 ) ,5153-7

2012 -To Present Elected, Charter Fellow of the National Academy of Inventors

2012 -2014 Elected Chair, Fellows of the Graduate School, University of Cincinnati

2011 -2012 One Hundred Wise Women, Cincinnati

2011 -To Present Elected American Association for the Advancement of Science (AAAS) Fellow

2010 -To Present Sigma Xi, elected as a full member

2009 -2011 Third Frontier Advisory Board (appointed by the Governor, State of Ohio)

2009 -2010 Leadership Cincinnati

2007 -2011 APLU (formerly NASULGC), Council on Research Policy and Graduate Education Executive Committee, Class of 2010

2009 -2011 Chair, Council of Sponsoring Institutions, Oak Ridge Associated Universities

2007 -2009 Elected Vice Chair, Council of Sponsoring Institutions, Oak Ridge Associated Universities

2006 -2006 NIH Special Review Panel, Liver Procurement Contract

2011 -2012 NIH Advisory Committee to the Director – Biomedical Workforce Taskforce

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati  Ohio, 45229-7007
Phone: 513-636-4816
Fax: 513-803-9182
sandra.degen@uc.edu