Rodrigo Deliberato

My research focuses on the investigation of high-resolution clinical data and the analytical challenges associated with multimodal data integration. We leverage advanced machine learning and AI methodologies to analyze these rich datasets and identify treatable traits—distinct physiologic derangements characterized by immune phenotypes or biomarker profiles that reliably predict response to targeted therapies or interventions. This work integrates high-resolution electronic medical record (EMR) data to enable more precise, personalized, and mechanism-based clinical decision-making.

Post Doctoral Fellowship: Massachussets Institute of Technology Cambridge, USA, (Data Science & AI)

Doctoral Degree: Universidade Federal do Estado de São Paulo São Paulo, Brazil,

Master Degree: Universidade federal do Estado de São Paulo São Paulo, Brazil,

MD: Universidade de Mogi das Cruzes São Paulo, Brazil,

Peer Reviewed Publications

Gutfreund, Maria Celidonio; Callado, Gustavo Yano; Pardo, Isabele; Hsieh, Mariana Kim; Celeghini, Patrícia Deffune; Lopes, Gabriel O V; Marra, Pedro S; Cheng, Yan Runa; Kobayashi, Takaaki; Pinho, João Renato Rebello; Generoso, José Roberto; Bulgarelli, Lucas; Mendonça, Eneida A; Deliberato, Rodrigo Octávio; Amgarten, Deyvid Emanuel; Malta, Fernanda de Mello; Edmond, Michael B; Marra, Alexandre R  (2026). Metagenomic next-generation sequencing in pediatric infectious disease diagnosis: A comprehensive systematic literature review and meta-analysis. Diagnostic microbiology and infectious disease, 114 (4) , 117248More Information

Ferreira, Julia Messina Gonzaga; Generoso, José Roberto; Marra, Alexandre R; Deliberato, Rodrigo Octávio; Dewan, Maya; Loeb, Daniel; Real, Francis; Collins, Kelly; Ely, Kelly; Zackoff, Matthew; Lopes, Gabriel de Oliveira Vasques; Pardo, Isabele; Gutfreund, Maria Celidonio; Callado, Gustavo Yano; Mendonça, Eneida A  (2025). Effectiveness of Low-cost, Technology-enhanced Simulation Training for Healthcare Training in Low-and Middle-income Countries (LMICs): A Systematic Literature Review. Journal of general internal medicine, 40 (16) , 4040-4050More Information

Salluh, Jorge I F; Moralez, Giulliana M; Tracy, Alexander; Deliberato, Rodrigo Octavio  (2025). ICU scoring systems: current perspectives and future directions. Current opinion in critical care, 31 (5) , 608-615More Information

Venkatesh, Balasubramanian; Rey, Diego Ariel; Evans, David M; Yao, Lijing; Finfer, Simon; Bellomo, Rinaldo; Silva, Tiago Chedraoui; Cohen, Jeremy; Qiu, Yu; Lucena, Wellington Dos Reis; Hammond, Naomi; Myburgh, John; Li, Qiang; Damiani, Lucas Petri; Devaux, Anthony; Deliberato, Rodrigo Octavio  (2025). A gene expression-based approach for the precision use of hydrocortisone in septic shock patients; a secondary analysis of the ADRENAL trial. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 27 (2) , 100109More Information

Marra, Pedro S; Marra, Alexandre R; Chen, Eileen; Kobayashi, Takaaki; Celeghini, Patrícia Deffune; Gutfreund, Maria Celidonio; Pardo, Isabele; Lopes, Gabriel O V; Hsieh, Mariana Kim; Boodhoo, Nicole A; Fu, Daniel; Torres-Espinosa, Michael A; Li, Yimeng; Deliberato, Rodrigo Octávio; Algain, Sulwan Mujahid A; Salinas, Jorge L; Edmond, Michael B; Amgarten, Deyvid Emanuel; de Mello Malta, Fernanda; Dos Santos, Nathalia Villa; Pinho, João Renato Rebello; Louine, Martineau; Wilson, Michael R  (2025). Metagenomic Next-generation Sequencing in Patients With Infectious Meningoencephalitis: A Comprehensive Systematic Literature Review and Meta-analysis. Open forum infectious diseases, 12 (5) , ofaf274More Information

Siuba, Matthew T; Bulgarelli, Lucas; Duggal, Abhijit; Cavalcanti, Alexandre B; Zampieri, Fernando G; Rey, Diego Ariel; Lucena, Wellington Dos Reis; Maia, Israel S; Paisani, Denise M; Laranjeira, Ligia N; Neto, Ary Serpa; Deliberato, Rodrigo Octávio  (2024). Differential Effect of Positive End-Expiratory Pressure Strategies in Patients With ARDS: A Bayesian Analysis of Clinical Subphenotypes. Chest, 166 (4) , 754-764More Information

Callado, Gustavo Yano; Pardo, Isabele; Gutfreund, Maria Celidonio; Deliberato, Rodrigo Octávio; Holubar, Marisa; Salinas, Jorge L; Marra, Christina M; Perencevich, Eli N; Marra, Alexandre R  (2024). Insights Into Treatment Alternatives for Neurosyphilis: Systematic Literature Review and Meta-Analysis. Sexually transmitted diseases, 51 (10) , 641-647More Information

Chaves, Renato Carneiro de Freitas; Barbas, Carmen Silvia Valente; Queiroz, Veronica Neves Fialho; Serpa Neto, Ary; Deliberato, Rodrigo Octavio; Pereira, Adriano José; Timenetsky, Karina Tavares; Silva Júnior, João Manoel; Takaoka, Flávio; de Backer, Daniel; Celi, Leo Anthony; Corrêa, Thiago Domingos  (2024). Assessment of fluid responsiveness using pulse pressure variation, stroke volume variation, plethysmographic variability index, central venous pressure, and inferior vena cava variation in patients undergoing mechanical ventilation: a systematic review and meta-analysis. Critical care (London, England), 28 (1) , 289More Information

Torbic, Heather; Bulgarelli, Lucas; Deliberato, Rodrigo Octavio; Duggal, Abhijit  (2024). Potential Impact of Subphenotyping in Pharmacologic Management of Acute Respiratory Distress Syndrome. Journal of pharmacy practice, 37 (4) , 955-966More Information

Callado, Gustavo Yano; Gutfreund, Maria Celidonio; Pardo, Isabele; Hsieh, Mariana Kim; Lin, Vivian; Sampson, Mindy Marie; Nava, Guillermo Rodriguez; Marins, Tássia Aporta; Deliberato, Rodrigo Octávio; Martino, Marinês Dalla Valle; Holubar, Marisa; Salinas, Jorge L; Marra, Alexandre R  (2024). Syphilis Treatment: Systematic Review and Meta-Analysis Investigating Nonpenicillin Therapeutic Strategies. Open forum infectious diseases, 11 (4) , ofae142More Information

Rincon, Teresa A; Raffa, Jesse; Celi, Leo Anthony; Badawi, Omar; Johnson, Alistair E W; Pollard, Tom; Deliberato, Rodrigo Octávio; Pierce, Janet D  (2023). Evaluation of evolving sepsis screening criteria in discriminating suspected sepsis and mortality among adult patients admitted to the intensive care unit. International journal of nursing studies, 145, 104529More Information

Yao, Lijing; Rey, Diego Ariel; Bulgarelli, Lucas; Kast, Rachel; Osborn, Jeff; Van Ark, Emily; Fang, Li Tai; Lau, Bayo; Lam, Hugo; Teixeira, Leonardo Maestri; Neto, Ary Serpa; Bellomo, Rinaldo; Deliberato, Rodrigo Octávio  (2022). Gene Expression Scoring of Immune Activity Levels for Precision Use of Hydrocortisone in Vasodilatory Shock. Shock (Augusta, Ga.), 57 (3) , 384-391More Information

Duggal, Abhijit; Kast, Rachel; Van Ark, Emily; Bulgarelli, Lucas; Siuba, Matthew T; Osborn, Jeff; Rey, Diego Ariel; Zampieri, Fernando G; Cavalcanti, Alexandre Biasi; Maia, Israel; Paisani, Denise M; Laranjeira, Ligia N; Serpa Neto, Ary; Deliberato, Rodrigo Octávio  (2022). Identification of acute respiratory distress syndrome subphenotypes de novo using routine clinical data: a retrospective analysis of ARDS clinical trials. BMJ open, 12 (1) , e053297More Information

Heilmann, Eva; Gregoriano, Claudia; Annane, Djillali; Reinhart, Konrad; Bouadma, Lila; Wolff, Michel; Chastre, Jean; Luyt, Charles-Edouard; Tubach, Florence; Branche, Angela R; Briel, Matthias; Christ-Crain, Mirjam; Welte, Tobias; Corti, Caspar; de Jong, Evelien; Nijsten, Maarten; de Lange, Dylan W; van Oers, Jos A H; Beishuizen, Albertus; Girbes, Armand R J; Deliberato, Rodrigo O; Schroeder, Stefan; Kristoffersen, Kristina B; Layios, Nathalie; Damas, Pierre; Lima, Stella S S; Nobre, Vandack; Wei, Long; Oliveira, Carolina F; Shehabi, Yahya; Stolz, Daiana; Tamm, Michael; Verduri, Alessia; Wang, Jin-Xiang; Drevet, Sabine; Gavazzi, Gaetan; Mueller, Beat; Schuetz, Philipp  (2021). Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials. Age and ageing, 50 (5) , 1546-1556More Information

Swart, Pien; Deliberato, Rodrigo Octavio; Johnson, Alistair E W; Pollard, Tom J; Bulgarelli, Lucas; Pelosi, Paolo; de Abreu, Marcelo Gama; Schultz, Marcus J; Neto, Ary Serpa  (2021). Impact of sex on use of low tidal volume ventilation in invasively ventilated ICU patients-A mediation analysis using two observational cohorts. PloS one, 16 (7) , e0253933More Information

Reis, Aline Mela Dos; Midega, Thais Dias; Deliberato, Rodrigo Octavio; Johnson, Alistair Ew; Bulgarelli, Lucas; Correa, Thiago Domingos; Celi, Leo Anthony; Pelosi, Paolo; Gama De Abreu, Marcelo; Schultz, Marcus J; Serpa Neto, Ary  (2021). Effect of spontaneous breathing on ventilator-free days in critically ill patients-an analysis of patients in a large observational cohort. Annals of translational medicine, 9 (9) , 783More Information

Bulgarelli, Lucas; Deliberato, Rodrigo Octávio; Johnson, Alistair E W  (2020). Prediction on critically ill patients: The role of "big data". Journal of critical care, 60, 64-68More Information

Danziger, John; Ángel Armengol de la Hoz, Miguel; Li, Wenyuan; Komorowski, Matthieu; Deliberato, Rodrigo Octávio; Rush, Barret N M; Mukamal, Kenneth J; Celi, Leo; Badawi, Omar  (2020). Temporal Trends in Critical Care Outcomes in U.S. Minority-Serving Hospitals. American journal of respiratory and critical care medicine, 201 (6) , 681-687More Information

Serpa Neto, Ary; Deliberato, Rodrigo Octavio; Johnson, Alistair Ew; Pollard, Tom J; Celi, Leo A; Pelosi, Paolo; Gama de Abreu, Marcelo; Schultz, Marcus J  (2019). Normalization of mechanical power to anthropometric indices: impact on its association with mortality in critically ill patients. Intensive care medicine, 45 (12) , 1835-1837More Information

Deliberato, Rodrigo Octávio; Escudero, Guilherme Goto; Bulgarelli, Lucas; Neto, Ary Serpa; Ko, Stephanie Q; Campos, Niklas Soderberg; Saat, Berke; Amaro, Edson; Lopes, Fabio Silva; Johnson, Alistair Ew  (2019). SEVERITAS: An externally validated mortality prediction for critically ill patients in low and middle-income countries. International journal of medical informatics, 131, 103959More Information

Cosgriff, Christopher V; Celi, Leo Anthony; Ko, Stephanie; Sundaresan, Tejas; Armengol de la Hoz, Miguel Ángel; Kaufman, Aaron Russell; Stone, David J; Badawi, Omar; Deliberato, Rodrigo Octavio  (2019). Developing well-calibrated illness severity scores for decision support in the critically ill. NPJ digital medicine, 2, 76More Information

Meier, Marc A; Branche, Angela; Neeser, Olivia L; Wirz, Yannick; Haubitz, Sebastian; Bouadma, Lila; Wolff, Michel; Luyt, Charles E; Chastre, Jean; Tubach, Florence; Christ-Crain, Mirjam; Corti, Caspar; Jensen, Jens-Ulrik S; Deliberato, Rodrigo O; Kristoffersen, Kristina B; Damas, Pierre; Nobre, Vandack; Oliveira, Carolina F; Shehabi, Yahya; Stolz, Daiana; Tamm, Michael; Mueller, Beat; Schuetz, Philipp  (2019). Procalcitonin-guided Antibiotic Treatment in Patients With Positive Blood Cultures: A Patient-level Meta-analysis of Randomized Trials. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 69 (3) , 388-396More Information

Bulgarelli, Lucas; Deliberato, Rodrigo Octavio; Stone, David J; Celi, Leo Anthony; Johnson, Alistair E W  (2019). The authors reply. Critical care medicine, 47 (7) , e612More Information

Deliberato, Rodrigo Octavio; Serpa Neto, Ary; Komorowski, Matthieu; Stone, David J; Ko, Stephanie Q; Bulgarelli, Lucas; Rodrigues Ponzoni, Carolina; de Freitas Chaves, Renato Carneiro; Celi, Leo Anthony; Johnson, Alistair E W  (2019). An Evaluation of the Influence of Body Mass Index on Severity Scoring. Critical care medicine, 47 (2) , 247-253More Information

, ; Núñez Reiz, Antonio; Martínez Sagasti, Fernando; Álvarez González, Manuel; Blesa Malpica, Antonio; Martín Benítez, Juan Carlos; Nieto Cabrera, Mercedes; Del Pino Ramírez, Ángela; Gil Perdomo, José Miguel; Prada Alonso, Jesús; Celi, Leo Anthony; Armengol de la Hoz, Miguel Ángel; Deliberato, Rodrigo; Paik, Kenneth; Pollard, Tom; Raffa, Jesse; Torres, Felipe; Mayol, Julio; Chafer, Joan; González Ferrer, Arturo; Rey, Ángel; González Luengo, Henar; Fico, Giuseppe; Lombroni, Ivana; Hernandez, Liss; López, Laura; Merino, Beatriz; Cabrera, María Fernanda; Arredondo, María Teresa; Bodí, María; Gómez, Josep; Rodríguez, Alejandro; Sánchez García, Miguel  (2019). Big data and machine learning in critical care: Opportunities for collaborative research. Medicina intensiva, 43 (1) , 52-57More Information

Serpa Neto, Ary; Deliberato, Rodrigo Octavio; Johnson, Alistair E W; Bos, Lieuwe D; Amorim, Pedro; Pereira, Silvio Moreto; Cazati, Denise Carnieli; Cordioli, Ricardo L; Correa, Thiago Domingos; Pollard, Tom J; Schettino, Guilherme P P; Timenetsky, Karina T; Celi, Leo A; Pelosi, Paolo; Gama de Abreu, Marcelo; Schultz, Marcus J  (2018). Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts. Intensive care medicine, 44 (11) , 1914-1922More Information

Wirz, Yannick; Meier, Marc A; Bouadma, Lila; Luyt, Charles E; Wolff, Michel; Chastre, Jean; Tubach, Florence; Schroeder, Stefan; Nobre, Vandack; Annane, Djillali; Reinhart, Konrad; Damas, Pierre; Nijsten, Maarten; Shajiei, Arezoo; deLange, Dylan W; Deliberato, Rodrigo O; Oliveira, Carolina F; Shehabi, Yahya; van Oers, Jos A H; Beishuizen, Albertus; Girbes, Armand R J; de Jong, Evelien; Mueller, Beat; Schuetz, Philipp  (2018). Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Critical care (London, England), 22 (1) , 191More Information

Schuetz, Philipp; Bolliger, Rebekka; Merker, Meret; Christ-Crain, Mirjam; Stolz, Daiana; Tamm, Michael; Luyt, Charles E; Wolff, Michel; Schroeder, Stefan; Nobre, Vandack; Reinhart, Konrad; Branche, Angela; Damas, Pierre; Nijsten, Maarten; Deliberato, Rodrigo O; Verduri, Alessia; Beghé, Bianca; Cao, Bin; Shehabi, Yahya; Jensen, Jens-Ulrik S; Beishuizen, Albertus; de Jong, Evelien; Briel, Matthias; Welte, Tobias; Mueller, Beat  (2018). Procalcitonin-guided antibiotic therapy algorithms for different types of acute respiratory infections based on previous trials. Expert review of anti-infective therapy, 16 (7) , 555-564More Information

Celi, Leo Anthony; Deliberato, Rodrigo; Vieira, Susana  (2018). Foreword. International journal of medical informatics, 113, 96-97More Information

Piza, Felipe Maia de Toledo; Celi, Leo Anthony; Deliberato, Rodrigo Octavio; Bulgarelli, Lucas; de Carvalho, Fabricio Rodrigues Torres; Filho, Roberto Rabello; de La Hoz, Miguel Angel Armengol; Kesselheim, Jennifer Cohn  (2018). Assessing team effectiveness and affective learning in a datathon. International journal of medical informatics, 112, 40-44More Information

Johnson, Alistair E W; Aboab, Jerome; Raffa, Jesse D; Pollard, Tom J; Deliberato, Rodrigo O; Celi, Leo A; Stone, David J  (2018). A Comparative Analysis of Sepsis Identification Methods in an Electronic Database. Critical care medicine, 46 (4) , 494-499More Information

Serpa Neto, Ary; Kugener, Guillaume; Bulgarelli, Lucas; Rabello Filho, Roberto; Hoz, Miguel Ángel Armengol de la; Johnson, Alistair Ew; Paik, Kenneth E; Torres, Felipe; Xie, Chen; Amaro Júnior, Edson; Ferraz, Leonardo José Rolim; Celi, Leo Anthony; Deliberato, Rodrigo Octavio  (2018). First Brazilian datathon in critical care. Revista Brasileira de terapia intensiva, 30 (1) , 6-8More Information

Deliberato, Rodrigo Octávio; Ko, Stephanie; Komorowski, Matthieu; Armengol de La Hoz, M A; Frushicheva, Maria P; Raffa, Jesse D; Johnson, Alistair E W; Celi, Leo Anthony; Stone, David J  (2018). Severity of Illness Scores May Misclassify Critically Ill Obese Patients. Critical care medicine, 46 (3) , 394-400More Information

Schuetz, Philipp; Wirz, Yannick; Sager, Ramon; Christ-Crain, Mirjam; Stolz, Daiana; Tamm, Michael; Bouadma, Lila; Luyt, Charles E; Wolff, Michel; Chastre, Jean; Tubach, Florence; Kristoffersen, Kristina B; Burkhardt, Olaf; Welte, Tobias; Schroeder, Stefan; Nobre, Vandack; Wei, Long; Bucher, Heiner C; Annane, Djillali; Reinhart, Konrad; Falsey, Ann R; Branche, Angela; Damas, Pierre; Nijsten, Maarten; de Lange, Dylan W; Deliberato, Rodrigo O; Oliveira, Carolina F; Maravić-Stojković, Vera; Verduri, Alessia; Beghé, Bianca; Cao, Bin; Shehabi, Yahya; Jensen, Jens-Ulrik S; Corti, Caspar; van Oers, Jos A H; Beishuizen, Albertus; Girbes, Armand R J; de Jong, Evelien; Briel, Matthias; Mueller, Beat  (2018). Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis. The Lancet. Infectious diseases, 18 (1) , 95-107More Information

Wirz, Yannick; Branche, Angela; Wolff, Michel; Welte, Tobias; Nobre, Vandack; Reinhart, Konrad; Falsey, Ann R; Damas, Pierre; Beishuizen, Albertus; Deliberato, Rodrigo O; Shehabi, Yahya; Jensen, Jens-Ulrik S; Mueller, Beat; Schuetz, Philipp  (2017). Management of Respiratory Infections with Use of Procalcitonin: Moving toward More Personalized Antibiotic Treatment Decisions. ACS infectious diseases, 3 (12) , 875-879More Information

Schuetz, Philipp; Wirz, Yannick; Sager, Ramon; Christ-Crain, Mirjam; Stolz, Daiana; Tamm, Michael; Bouadma, Lila; Luyt, Charles E; Wolff, Michel; Chastre, Jean; Tubach, Florence; Kristoffersen, Kristina B; Burkhardt, Olaf; Welte, Tobias; Schroeder, Stefan; Nobre, Vandack; Wei, Long; Bucher, Heiner C; Bhatnagar, Neera; Annane, Djillali; Reinhart, Konrad; Branche, Angela; Damas, Pierre; Nijsten, Maarten; de Lange, Dylan W; Deliberato, Rodrigo O; Lima, Stella Ss; Maravić-Stojković, Vera; Verduri, Alessia; Cao, Bin; Shehabi, Yahya; Beishuizen, Albertus; Jensen, Jens-Ulrik S; Corti, Caspar; Van Oers, Jos A; Falsey, Ann R; de Jong, Evelien; Oliveira, Carolina F; Beghe, Bianca; Briel, Matthias; Mueller, Beat  (2017). Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. The Cochrane database of systematic reviews, 10 (10) , CD007498More Information

Deliberato, Rodrigo Octávio; Celi, Leo Anthony; Stone, David J  (2017). Clinical Note Creation, Binning, and Artificial Intelligence. JMIR medical informatics, 5 (3) , e24More Information

Deliberato, Rodrigo Octávio; Rocha, Leonardo Lima; Lima, Alex Heitor; Santiago, Caroline Reis Maia; Terra, Jose Cláudio Cyrineu; Dagan, Alon; Celi, Leo Anthony  (2017). Physician satisfaction with a multi-platform digital scheduling system. PloS one, 12 (3) , e0174127More Information

Pereira, Adriano José; Corrêa, Thiago Domingos; de Almeida, Francisca Pereira; Deliberato, Rodrigo Octávio; Lobato, Michelle dos Santos; Akamine, Nelson; Silva, Eliézer; Cavalcanti, Alexandre Biasi  (2015). Inaccuracy of Venous Point-of-Care Glucose Measurements in Critically Ill Patients: A Cross-Sectional Study. PloS one, 10 (6) , e0129568More Information

Deliberato, Rodrigo Octavio; Marra, Alexandre R; Sanches, Paula Rodrigues; Martino, Marines Dalla Valle; Ferreira, Carlos Eduardo dos Santos; Pasternak, Jacyr; Paes, Angela Tavares; Pinto, Lilian Moreira; dos Santos, Oscar Fernando Pavão; Edmond, Michael B  (2013). Clinical and economic impact of procalcitonin to shorten antimicrobial therapy in septic patients with proven bacterial infection in an intensive care setting. Diagnostic microbiology and infectious disease, 76 (3) , 266-71More Information

Deliberato, Rodrigo Octávio; Marra, Alexandre R; Corrêa, Thiago Domingos; Martino, Marinês Dalla Vale; Correa, Luci; Dos Santos, Oscar Fernando Pavão; Edmond, Michael B  (2012). Catheter related bloodstream infection (CR-BSI) in ICU patients: making the decision to remove or not to remove the central venous catheter. PloS one, 7 (3) , e32687More Information