Pankaj Desai , PhD

Pankaj B. Desai is currently Professor and Director, Drug Development Graduate Program, College of Pharmacy, University of Cincinnati, Cincinnati, OH. His research interests include pre-clinical and clinical studies on drug metabolism, transport and pharmacokinetics. The current focus of his laboratory is on the regulation of drug-metabolizing enzymes and its relevance to clinical pharmacology of anti-cancer and antiretroviral drugs. Dr. Desai directs a vigorous, extramurally-funded research program and has authored numerous peer-reviewed publications. His research has been funded by NIH, Komen Foundation, American Cancer society and various pharmaceutical companies. He has mentored over 20 MS/Ph.D. students and was the principal architect for the novel graduate curriculum in drug development program at UC College of Pharmacy. Dr. Desai is an active member of several organizations including American Association of Pharmaceutical Scientists, where he served as the chair of the Drug Metabolism Focus Group of AAPS from 2001-2003. He is currently a member of the Shulman Associates Institutional Review Board and of the Transitional Research and Drug Development (TRADD) Committee and Phase I /Early Clinical Pharmacology sub-committee of the Adults AIDS Clinical Trials Group. He also serves as a member of the Experimental Therapeutics Study Section for Department of Defense Breast Cancer Research Program. Dr. Desai has received numerous teaching and research excellence awards at both University of Louisiana and University of Cincinnati. These include the Researcher of the Year Award at ULM in 1994 and the President’s Excellence Award at UC in 2006.

Pharmacokinetics and pharmacodynamics of anticancer drugs, inter-individual and inter-species variation in drug metabolism, drug delivery systems

Investigators:Desai, Pankaj 05-01-2005 -07-31-2007 National Institute of General Medical Sciences Drug Interactions with Anti-HIV Protease Inhibitors Role:PI $158,754.00 Closed Level:Federal

Investigators:Desai, Pankaj 08-01-2005 -07-31-2006 Bioavailability Systems, LLC Influence of Spiro-Ortho-Ester Compounds from Grapefruit Juice on CYP3A4 Activity and Expression Role:PI $31,250.00 Closed Level:Industry

Grant: #Aventis FY03-01-A0-S0-E0 Investigators:Desai, Pankaj 09-01-2002 -08-31-2004 Sanofi-Aventis (France) Fibrinogen - Coated Docetaxel Microemulsions: A Novel Approach for Drug Targeting Role:PI $111,849.00 Closed Level:Foreign Industry

Investigators:Desai, Pankaj 05-01-2004 -04-30-2006 Susan G. Komen Breast Cancer Foundation Induction of drug metabolism and transport genes and activation of human PregnaneX Receptor by Tamoxifen Role:PI $30,000.00 Closed Level:Private Non-Profit

Investigators:Desai, Pankaj 08-01-2003 -07-31-2004 Sanofi-Aventis (France) Assessment of Potentially Cincally Relevant Drug-Drug Interactions Role:PI $77,500.00 Closed Level:Foreign Industry

Investigators:Desai, Pankaj 12-01-2004 -11-30-2006 Bristol-Myers Squibb Co. Assessment of the Potential Induction of Hepatic and Intestinal Enzymes and Transporters by Efavirenz Role:PI $25,000.00 Closed Level:Industry

Grant: #RPR-11-01-A0-S0-E0 Investigators:Desai, Pankaj 01-01-2000 -12-31-2001 Rhone-Poulenc Rorer Pharmaceuticals CSF Pharmacokinetics of Taxotere in Combination with RMP-7 Role:PI $45,000.00 Closed Level:Industry

Grant: #PHOENIX-01-A0-S0-E0 Investigators:Desai, Pankaj 07-01-1999 -06-30-2001 Phoenix International Life Science, Inc. Innovative Pharmacokinetic-Pharmacodynamic Analyses Role:PI $9,910.00 Closed Level:Industry

Grant: #RPR-12-01-A0-S0-E0 Investigators:Desai, Pankaj 03-01-2000 -02-28-2001 Rhone-Poulenc Rorer Pharmaceuticals Induction of Hepatic Cytochrome P450 Enzyme(s) by Docetaxel Role:PI $50,000.00 Closed Level:Industry

Grant: #SUGEN-05-01-A0-S0-E0 Investigators:Desai, Pankaj 09-01-2000 -08-31-2002 Sugen, Inc. Pharmacokinetic Interaction Between Paclitaxel and SU5416 Role:PI $102,080.00 Closed Level:Industry

Grant: #ACS - Taxane-01-A0-S0-E0 Investigators:Desai, Pankaj 07-01-2001 -06-30-2002 American Cancer Society - Ohio Chapter Molecular Mechanisms for Increased CYP3A4 Expression by Taxane Anti-Cancer Agents Role:PI $19,800.00 Closed Level:Private Non-Profit

Grant: #2002-UC-41-02-A0-S0-E0 Investigators:Desai, Pankaj 07-01-2001 -06-30-2003 Eli Lilly and Company Influence of Ionizing Radiation on Brain Pharmacokinetics of Gemcitabine Role:PI $60,000.00 Closed Level:Industry

Grant: #BRISTOL-10-01-A0-S0-E0 Investigators:Desai, Pankaj 06-01-1997 -06-30-2000 Bristol-Myers Squibb Co. Evaluation of Pharmacokinetics and Pharmacodynamics of Radiation Sensitizing Doses of Taxol in Pancreatic Cancer Role:PI $25,000.00 Closed Level:Industry

Grant: #Komen BCTR0707983 PH Investigators:Chakraborty, Ranajit; Deka, Ranjan; Desai, Pankaj; Shaughnessy, Elizabeth 07-01-2007 -06-30-2010 Susan G. Komen Breast Cancer Foundation Clinical Assessment of Cytochrome P450 (CYP)3A4 Induction by Tamoxifen: Potential Impact of Hormonal and Genetic Factors Role:PI $297,968.00 Closed Level:Private Non-Profit

Grant: #SRS 006071 Investigators:Desai, Pankaj 01-20-2009 -10-31-2009 Abraxis BioScience, LLC Studies in Localized Delivery of Abraxane, a Novel Paclitaxel Dosage Form Role:PI $15,240.00 Closed Level:Industry

Grant: #SRS 006624 Investigators:Desai, Pankaj 10-01-2009 -09-30-2010 Johnson & Johnson The Effects of Darunavir Plus Ritonavir on the Pharmacokinetics and Pharmacodynamics of Rosuvastatin Role:PI $33,432.00 Closed Level:Industry

Grant: #SRS 006897 Investigators:Desai, Pankaj 06-01-2010 -05-31-2013 Eli Lilly and Company Pharmacokinetics of Paclitaxel and Gemcitabine in a Phase II Trial of Biweekly Gemcitabine, Paclitaxel and Bevacizumab as Frontline Therapy for Metastatic Breast Cancer Role:PI $9,000.00 Active Level:Industry

Grant: #1 R43 MH082461 Investigators:Desai, Pankaj 09-01-2010 -01-04-2011 National Institute of Mental Health Betahistine-Novel Therapeutic in Attention Deficit Hyperactivity Disorder Role:PI $18,000.00 Closed Level:Federal

Grant: #SRS 007158 Investigators:Desai, Pankaj 09-01-2010 -08-31-2012 Cincinnati Children's Hospital Medical Center Graduate Research (PhD) at the Division of Clinical Pharmacology at Cincinnati Children's Hospital Medical Center Role:PI $18,800.00 Closed Level:Private Non-Profit

Grant: #CRA - Desai Investigators:Desai, Pankaj 06-01-2012 -05-31-2013 Community Research CYP2D6 Genotyping in Phase I Studies Role:PI $62,846.00 Active Level:Industry

Grant: #CTA - Desai \ WS937635 Investigators:Desai, Pankaj 04-01-2012 -09-30-2013 Pfizer, Inc. Axitinib Pharmacokinetics and Pharmacodynamics in Patients with Glioblastoma Multiforme Role:PI $78,620.10 Active Level:Industry

Grant: #0000013121 / HDTRA1-12-C-0051 Investigators:Desai, Pankaj 10-01-2012 -09-30-2014 Defense Threat Reduction Agency Multi-pathogen Antiviral Medical Countermeasure Deploying FDA Approved Drug Role:PI $206,091.00 Active Level:Federal

Grant: #TECG20160468 Investigators:Desai, Pankaj 05-16-2016 -05-16-2017 Ohio Development Services Agency Novel Therapy for High Grade Gliomas: Repurposing Letrozole, an FDA Approved Drug, for an Orphan & Fast Track 505(b)(2) Application Role:PI $50,000.00 Active Level:State of Ohio

Grant: #17-65-BOGD Investigators:Ahmad, Syed; Bogdanov, Vladimir; Desai, Pankaj 07-01-2017 -06-30-2019 Pancreatic Cancer Network Disrupting Tissue Factor-beta1 integrin axis in pancreatic cancer Role:Collaborator $300,000.00 Active Level:Private Non-Profit

Grant: #HHSN272201700034I (Master Agreement) Investigators:Cushion, Melanie; Desai, Pankaj; Sallans, Larry 07-14-2017 -07-13-2024 National Institute of Allergy and Infectious Diseases PRE-CLINICAL MODELS OF INFECTIOUS DISEASES: Task Area A: Small Animal Models of Infectious Diseases Role:Collaborator $.00 Active Level:Federal

Grant: #139257 / W81XWH-17- 1-0666 Investigators:Desai, Pankaj; McCormack, Francis 09-30-2017 -09-29-2018 Department of the Army Medical Research Acquisition Activity Therapeutic Benefit of HSP90 Inhibition in Pulmonary Fibrosis Role:Collaborator $43,149.00 Awarded Level:Federal

Grant: #139257 / W81XWH-17-1-0666 (011239-yr1) Investigators:Desai, Pankaj; McCormack, Francis 10-01-2018 -09-30-2019 Department of the Army Medical Research Acquisition Activity Therapeutic Benefit of HSP90 Inhibition in Pulmonary Fibrosis Role:Collaborator $44,241.16 Active Level:Federal

Grant: #310252 / R01NS114074 Investigators:Desai, Pankaj 12-01-2019 -11-30-2021 National Institute of Neurological Disorders and Stroke Bystander gene deletions in cancer: mechanisms of therapeutic opportunities and challenges Role:PI $29,434.00 Awarded Level:Federal

Grant: #Laboratory Services Agreement Investigators:Desai, Pankaj 07-01-2020 -06-30-2021 Cincinnati Children's Hospital Medical Center Pharmacokinetic Analysis of Venetoclax Role:PI 20800.00 Active Level:Non Profit

Grant: #317613 / R01NS099162 Investigators:Desai, Pankaj 05-01-2022 -04-30-2027 Cincinnati Children's Hospital Medical Center Mechanisms of Biguanide Sensitivity in Glioma Role:PI 0.00 Hold Level:Non Profit

Grant: #R61NS128232 Investigators:Desai, Pankaj; Gudelsky, Gary; Phoenix, Timothy; Plas, David; Rodenberg, Cynthia; Sengupta, Soma; Wise-Draper, Trisha 08-01-2022 -07-31-2025 National Institute of Neurological Disorders and Stroke Translational Studies to facilitate Rational Therapeutic Combinations of Letrozole for the Treatment of Glioblastoma Role:PI 389244.00 Awarded Level:Federal

Investigators:Chaudhary, Rekha; Desai, Pankaj; Medvedovic, Mario; Plas, David; Rai, Shesh; Wise-Draper, Trisha; Zuccarello, Mario 11-30-2023 -11-30-2024 Dr. Ralph and Marian Falk Medical Research Trust Clinical and Correlative Translational Studies for Repurposing Letrozole as a Novel Therapeutic for Glioblastoma: Proof of Efficacy in Combination with Metronomic Temozolomide Role:PI 211322.00 Hold Level:Non Profit

Grant: #NIHAI75N93023R00003 Investigators:Cushion, Melanie; Desai, Pankaj -12-02-2025 National Institute of Allergy and Infectious Diseases PRE-CLINICAL MODELS OF INFECTIOUS DISEASES Task Area A: Small Animal Models of Infectious Diseases Sample Task Order A01 Role:Collaborator 0.00 Hold Level:Federal

Grant: #SA0000658 LSA Investigators:Desai, Pankaj 08-01-2024 -07-31-2025 Cincinnati Children's Hospital Medical Center Pharmacokinetic study of Venetoclax tablets crushed and dissolved into a solution in children Role:PI 30000.00 Hold Level:Non Profit

Grant: #R01CA279962 JIT Investigators:Desai, Pankaj; Faber, Ed; Kotagiri, Nalinikanth; Sertorio, Mathieu; Xie, Changchun 12-01-2023 -11-30-2028 National Cancer Institute Genetically-encoded molecular imaging of genome-edited immune cells Role:Collaborator 0.00 Hold Level:Federal

Grant: #A1133560; R01NS099162 Investigators:Desai, Pankaj 12-01-2024 -04-30-2027 National Institute of Neurological Disorders and Stroke Mechanisms of Biguanide Sensitivity in GBM Role:PI 33913.00 Hold Level:Federal

Peer Reviewed Publications

Mersich, Ian; Congrove, Sunny; Horchar, Matthew; Caceres, Roman; Muraleedharan, Ranjithmenon; Desai, Janki; Desai, Pankaj; Sallans, Larry; Reisz, Julie A; Grier, Abby; Hass, Matthew R; Donmez, Omer; Yin, Cailing; Weirauch, Matthew T; Kottyan, Leah; Stevenson, Charles B; Sun, Claire; de Blank, Peter; Pillay-Smiley, Natasha; Hummel, Trent R; Elumalai, Nagarajan; Tavassoli, Ali; Firestein, Ron; Phoenix, Timothy N; D'Alessandro, Angelo; Dasgupta, Biplab (2025. ) Integrative Multi-Omics Analysis Identifies Nuclear Factor I as a Key Driver of Dysregulated Purine Metabolism in DIPG.bioRxiv : the preprint server for biology, , More Information

Illamola, Sílvia M; Bhongsatiern, Jiraganya Jj; Birnbaum, Angela K; Kumar, Shaun S; Courter, Joshua D; Haslam, David B; Allegaert, Karel; Reith, David M; Desai, Pankaj B; Sherwin, Catherine M (2025. ) Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation.Frontiers in antibiotics, , 4 ,1568931 More Information

Bhattacharya, Debanjan; Barrile, Riccardo; Toukam, Donatien Kamdem; Gawali, Vaibhavkumar S; Kallay, Laura; Ahmed, Taukir; Brown, Hawley; Rezvanian, Sepideh; Karve, Aniruddha; Desai, Pankaj B; Medvedovic, Mario; Wang, Kyle; Ionascu, Dan; Harun, Nusrat; Vallabhapurapu, Subrahmanya; Wang, Chenran; Qi, Xiaoyang; Baschnagel, Andrew M; Kritzer, Joshua A; Cook, James M; Pomeranz Krummel, Daniel A; Sengupta, Soma (2024. ) GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors.Cancers, , 16 (18 ) , More Information

Oatman, Nicole; Gawali, Mruniya V; Congrove, Sunny; Cáceres, Román; Sukumaran, Abitha; Gupta, Nishtha; Murugesan, Narmadha; Arora, Priyanka; Subramanian, Srividhya; Choi, Kwangmin; Abdel-Malek, Zalfa; Reisz, Julie A; Stephenson, Daniel; Amaravadi, Ravi; Desai, Pankaj; D'Alessandro, Angelo; Komurov, Kakajan; Dasgupta, Biplab (2024. ) A Multimodal Drug-Diet-Immunotherapy Combination Restrains Melanoma Progression and Metastasis.Cancer research, , 84 (14 ) ,2333-2351 More Information

Harlan, Sarah Schuman; Philpott, Carolyn D; Keegan, Shaun P; Droege, Molly E; Karve, Aniruddha S; Foreman, Brandon; Wakefield, Devin; Mueller, Eric W; Sangha, Kiranpal; Ngwenya, Laura B; Courter, Joshua D; Desai, Pankaj; Droege, Christopher (2024. ) Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury.The Annals of pharmacotherapy, , 58 (7 ) ,705-714 More Information

Desai, Pankaj B; Karve, Aniruddha S; Zawit, Misam; Arora, Priyanka; Dave, Nimita; Awosika, Joy; Li, Ningjing; Fuhrman, Bethany; Medvedovic, Mario; Sallans, Larry; Kendler, Ady; DasGupta, Biplab; Plas, David; Curry, Richard; Zuccarello, Mario; Chaudhary, Rekha; Sengupta, Soma; Wise-Draper, Trisha M (2024. ) A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas.Clinical cancer research : an official journal of the American Association for Cancer Research, , 30 (10 ) ,2068-2077 More Information

Karve, Aniruddha S; Desai, Janki M; Gadgil, Sidharth N; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Yogendran, Lalanthica; Sengupta, Soma; Plas, David R; Desai, Pankaj B (2024. ) A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance.International journal of molecular sciences, , 25 (6 ) , More Information

Bhattacharya, Debanjan; Barille, Riccardo; Toukam, Donatien Kamdem; Gawali, Vaibhavkumar S; Kallay, Laura; Ahmed, Taukir; Brown, Hawley; Rezvanian, Sepideh; Karve, Aniruddha; Desai, Pankaj B; Medvedovic, Mario; Wang, Kyle; Ionascu, Dan; Harun, Nusrat; Wang, Chenran; Baschnagel, Andrew M; Kritzer, Joshua A; Cook, James M; Pomeranz Krummel, Daniel A; Sengupta, Soma (2023. ) GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors.bioRxiv : the preprint server for biology, , More Information

Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B (2022. ) Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole.Cancer chemotherapy and pharmacology, , 90 (4 ) ,345-356 More Information

Desai, Janki M; Karve, Aniruddha S; Gudelsky, Gary A; Gawali, Mruniya V; Seibel, William; Sallans, Larry; DasGupta, Biplab; Desai, Pankaj B (2022. ) Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma.Investigational new drugs, , 40 (5 ) ,944-952 More Information

Arora, Priyanka; Gudelsky, Gary; Desai, Pankaj B (2021. ) Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights.PloS one, , 16 (4 ) ,e0248579 More Information

Mishra, Rosalin; Yuan, Long; Patel, Hima; Karve, Aniruddha S; Zhu, Haizhou; White, Aaron; Alanazi, Samar; Desai, Pankaj; Merino, Edward J; Garrett, Joan T (2021. ) Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth.International journal of molecular sciences, , 22 (4 ) , More Information

Oatman, Nicole; Dasgupta, Nupur; Arora, Priyanka; Choi, Kwangmin; Gawali, Mruniya V; Gupta, Nishtha; Parameswaran, Sreeja; Salomone, Joseph; Reisz, Julie A; Lawler, Sean; Furnari, Frank; Brennan, Cameron; Wu, Jianqiang; Sallans, Larry; Gudelsky, Gary; Desai, Pankaj; Gebelein, Brian; Weirauch, Matthew T; D'Alessandro, Angelo; Komurov, Kakajan; Dasgupta, Biplab (2021. ) Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer.Science advances, , 7 (7 ) , More Information

Koehler, Abigail; Karve, Aniruddha; Desai, Pankaj; Arbiser, Jack; Plas, David R; Qi, Xiaoyang; Read, Renee D; Sasaki, Atsuo T; Gawali, Vaibhavkumar S; Toukam, Donatien K; Bhattacharya, Debanjan; Kallay, Laura; Pomeranz Krummel, Daniel A; Sengupta, Soma (2021. ) Reuse of Molecules for Glioblastoma Therapy.Pharmaceuticals (Basel, Switzerland), , 14 (2 ) , More Information

Davis, Harold W; Vallabhapurapu, Subrahmanya D; Chu, Zhengtao; Wyder, Michael A; Greis, Kenneth D; Fannin, Venette; Sun, Ying; Desai, Pankaj B; Pak, Koon Y; Gray, Brian D; Qi, Xiaoyang (2020. ) Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles.Cells, , 9 (9 ) , More Information

Gulati, Shuchi; Desai, Janki; Palackdharry, Sarah M; Morris, John C; Zhu, Zheng; Jandarov, Roman; Riaz, Muhammad K; Takiar, Vinita; Mierzwa, Michelle; Gutkind, J Silvio; Molinolo, Alfredo; Desai, Pankaj B; Sadraei, Nooshin Hashemi; Wise-Draper, Trisha M (2020. ) Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer.Cancer, , 126 (2 ) ,354-362 More Information

Arora, Priyanka; Adams, Courtney Huff; Gudelsky, Gary; DasGupta, Biplab; Desai, Pankaj B (2019. ) Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats.Cancer chemotherapy and pharmacology, , 83 (1 ) ,81-89 More Information

Ananthula, Hari Krishna; Parker, Scott; Touchette, Erin; Buller, R Mark; Patel, Gopi; Kalman, Daniel; Salzer, Johanna S; Gallardo-Romero, Nadia; Olson, Victoria; Damon, Inger K; Moir-Savitz, Tessa; Sallans, Larry; Werner, Milton H; Sherwin, Catherine M; Desai, Pankaj B (2018. ) Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents.BMC pharmacology & toxicology, , 19 (1 ) ,80 More Information

Lazzarini, Cristina; Haranahalli, Krupanandan; Rieger, Robert; Ananthula, Hari Krishna; Desai, Pankaj B; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie T; Ruzsicska, Bela; Haley, John; Ojima, Iwao; Del Poeta, Maurizio (2018. ) Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids.Antimicrobial agents and chemotherapy, , 62 (5 ) , More Information

Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio (2018. ) Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".mBio, , 9 (2 ) , More Information

Mehta, Rajiv; Kabrawala, Mayank; Nandwani, Subhash; Desai, Pankaj; Bhayani, Vishwa; Patel, Sanjay; Parekh, Viral (2018. ) Safety and Efficacy of Sofosbuvir and Daclatasvir for Hepatitis C Virus Infection in Patients with β-Thalassemia Major.Journal of clinical and experimental hepatology, , 8 (1 ) ,3-6 More Information

Wise-Draper, Trisha M; Moorthy, Ganesh; Salkeni, Mohamad A; Karim, Nagla Abdel; Thomas, Hala Elnakat; Mercer, Carol A; Beg, M Shalaan; O'Gara, Sue; Olowokure, Olugbenga; Fathallah, Hassana; Kozma, Sara C; Thomas, George; Rixe, Olivier; Desai, Pankaj; Morris, John C (2017. ) A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies.Targeted oncology, , 12 (3 ) ,323-332 More Information

Bhongsatiern, Jiraganya; Stockmann, Chris; Yu, Tian; Constance, Jonathan E; Moorthy, Ganesh; Spigarelli, Michael G; Desai, Pankaj B; Sherwin, Catherine M T (2016. ) Renal Function Descriptors in Neonates: Which Creatinine-Based Formula Best Describes Vancomycin Clearance?.Journal of clinical pharmacology, , 56 (5 ) ,528-40 More Information

Bhongsatiern, Jiraganya; Stockmann, Chris; Roberts, Jessica K; Yu, Tian; Korgenski, Kent E; Spigarelli, Michael G; Desai, Pankaj B; Sherwin, Catherine M T (2015. ) Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target.Therapeutic drug monitoring, , 37 (6 ) ,756-65 More Information

Moorthy, Ganesh; Sallee, Floyd; Gabbita, Prasad; Zemlan, Frank; Sallans, Larry; Desai, Pankaj B (2015. ) Safety, tolerability and pharmacokinetics of 2-pyridylacetic acid, a major metabolite of betahistine, in a phase 1 dose escalation study in subjects with ADHD.Biopharmaceutics & drug disposition, , 36 (7 ) ,429-39 More Information

Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio (2015. ) Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.mBio, , 6 (3 ) ,e00647 More Information

Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B (2015. ) Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.Molecular cancer therapeutics, , 14 (4 ) ,857-64 More Information

Krishan, Mansi; Gudelsky, Gary A; Desai, Pankaj B; Genter, Mary Beth (2014. ) Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain.Drug delivery, , 21 (1 ) ,8-16 More Information

Dave, Nimita; Gudelsky, Gary A; Desai, Pankaj B (2013. ) The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.Cancer chemotherapy and pharmacology, , 72 (2 ) ,349-57 More Information

Tong, Jenny; Dave, Nimita; Mugundu, Ganesh M; Davis, Harold W; Gaylinn, Bruce D; Thorner, Michael O; Tschöp, Matthias H; D'Alessio, David; Desai, Pankaj B (2013. ) The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.European journal of endocrinology, , 168 (6 ) ,821-8 More Information

Mu, Chaofeng; Dave, Nimita; Hu, Jing; Desai, Pankaj; Pauletti, Giovanni; Bai, Shuhua; Hao, Jiukuan (2013. ) Solubilization of flurbiprofen into aptamer-modified PEG-PLA micelles for targeted delivery to brain-derived endothelial cells in vitro.Journal of microencapsulation, , 30 (7 ) ,701-8 More Information

Samineni, Divya; Desai, Pankaj B; Sallans, Larry; Fichtenbaum, Carl J (2012. ) Steady-state pharmacokinetic interactions of darunavir/ritonavir with lipid-lowering agent rosuvastatin.Journal of clinical pharmacology, , 52 (6 ) ,922-31 More Information

Liu, Li; Mugundu, Ganesh M; Kirby, Brian J; Samineni, Divya; Desai, Pankaj B; Unadkat, Jashvant D (2012. ) Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR.Biopharmaceutics & drug disposition, , 33 (4 ) ,207-17 More Information

Mugundu, Ganesh M; Sallans, Larry; Guo, Yingying; Shaughnessy, Elizabeth A; Desai, Pankaj B (2012. ) Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.Drug metabolism and disposition: the biological fate of chemicals, , 40 (2 ) ,389-96 More Information

Kirby, Brian J; Collier, Ann C; Kharasch, Evan D; Dixit, Vaishali; Desai, Pankaj; Whittington, Dale; Thummel, Kenneth E; Unadkat, Jashvant D (2011. ) Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.Drug metabolism and disposition: the biological fate of chemicals, , 39 (12 ) ,2329-37 More Information

Jackson, Richard L; Greiwe, Jeffrey S; Desai, Pankaj B; Schwen, Richard J (2011. ) Single-dose and steady-state pharmacokinetic studies of S-equol, a potent nonhormonal, estrogen receptor β-agonist being developed for the treatment of menopausal symptoms. Menopause (New York, N.Y.), , 18 (2 ) ,185-93

He, Bing; Tang, Jie; Ding, Ying; Wang, Huijun; Sun, Yuyin; Shin, Jae Hong; Chen, Bin; Moorthy, Ganesh; Qiu, Judy; Desai, Pankaj; Wild, David J (2011. ) Mining relational paths in integrated biomedical data.PloS one, , 6 (12 ) ,e27506 More Information

Mugundu, Ganesh M; Hariparsad, Niresh; Desai, Pankaj B (2010. ) Impact of ritonavir, atazanavir and their combination on the CYP3A4 induction potential of efavirenz in primary human hepatocytes.Drug metabolism letters, , 4 (1 ) ,45-50 More Information

Gupta, Anshul; Mugundu, Ganesh M; Desai, Pankaj B; Thummel, Kenneth E; Unadkat, Jashvant D (2008. ) Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.Drug metabolism and disposition: the biological fate of chemicals, , 36 (6 ) ,1172-80 More Information

Sane, Rucha S; Buckley, Donna J; Buckley, Arthur R; Nallani, Srikanth C; Desai, Pankaj B (2008. ) Role of human pregnane X receptor in tamoxifen- and 4-hydroxytamoxifen-mediated CYP3A4 induction in primary human hepatocytes and LS174T cells.Drug metabolism and disposition: the biological fate of chemicals, , 36 (5 ) ,946-54 More Information

Apparaju, Sandhya Kiran; Gudelsky, Gary A; Desai, Pankaj B (2008. ) Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis.Cancer chemotherapy and pharmacology, , 61 (2 ) ,223-9 More Information

Dixit, Vaishali; Hariparsad, Niresh; Li, Fang; Desai, Pankaj; Thummel, Kenneth E; Unadkat, Jashvant D (2007. ) Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions.Drug metabolism and disposition: the biological fate of chemicals, , 35 (10 ) ,1853-9 More Information

Dixit, Vaishali; Hariparsad, Niresh; Desai, Pankaj; Unadkat, Jashvant D (2007. ) In vitro LC-MS cocktail assays to simultaneously determine human cytochrome P450 activities.Biopharmaceutics & drug disposition, , 28 (5 ) ,257-62 More Information

Al-Zoughool, Mustafa; Succop, Paul; Desai, Pankaj; Vietas, Jay; Talaska, Glenn (2006. ) Effect of N-glucuronidation on urinary bladder genotoxicity of 4-aminobiphenyl in male and female mice.Environmental toxicology and pharmacology, , 22 (2 ) ,153-9 More Information

Winhusen, Theresa; Somoza, Eugene; Singal, Bonita M; Harrer, Judy; Apparaju, Sandhya; Mezinskis, Juris; Desai, Pankaj; Elkashef, Ahmed; Chiang, C Nora; Horn, Paul (2006. ) Methylphenidate and cocaine: a placebo-controlled drug interaction study.Pharmacology, biochemistry, and behavior, , 85 (1 ) ,29-38 More Information

Kelly, Burnett; Melhem, Murad; Zhang, Jianhua; Kasting, Gerald; Li, Jinsong; Krishnamoorthy, Mahesh; Heffelfinger, Sue; Rudich, Steven; Desai, Pankaj; Roy-Chaudhury, Prabir (2006. ) Perivascular paclitaxel wraps block arteriovenous graft stenosis in a pig model.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, , 21 (9 ) ,2425-31 More Information

Desai, Pankaj B; Sane, Rucha S (2006. ) Metabolism and Pharmacokinetics of Anti-Cancer Drugs.Toxicology in vitro : an international journal published in association with BIBRA, , 20 (2 ) ,133-4 More Information

Melhem, Murad; Kelly, Burnett; Zhang, Jianhua; Kasting, Gerald; Li, Jinsong; Davis, Harold; Heffelfinger, Sue; Desai, Pankaj; Roy-Chaudhury, Prabir (2006. ) Development of a local perivascular paclitaxel delivery system for hemodialysis vascular access dysfunction: polymer preparation and in vitro activity.Blood purification, , 24 (3 ) ,289-98 More Information

Roy-Chaudhury, Prabir; Kelly, Burnett S; Melhem, Murad; Zhang, Jianhua; Li, Jinsong; Desai, Pankaj; Munda, Rino; Heffelfinger, Sue C (2005. ) Vascular access in hemodialysis: issues, management, and emerging concepts.Cardiology clinics, , 23 (3 ) ,249-73 More Information

Setchell, Kenneth D R; Brzezinski, Amnon; Brown, Nadine M; Desai, Pankaj B; Melhem, Murad; Meredith, Trevor; Zimmer-Nechimias, Linda; Wolfe, Brian; Cohen, Yoram; Blatt, Yoav (2005. ) Pharmacokinetics of a slow-release formulation of soybean isoflavones in healthy postmenopausal women.Journal of agricultural and food chemistry, , 53 (6 ) ,1938-44 More Information

Roy-Chaudhury, Prabir; Kelly, Burnett S; Melhem, Murad; Zhang, Jianhua; Li, Jinsong; Desai, Pankaj; Munda, Rino; Heffelfinger, Sue C (2005. ) Novel therapies for hemodialysis vascular access dysfunction: fact or fiction!.Blood purification, , 23 (1 ) ,29-35 More Information

Hariparsad, Niresh; Nallani, Srikanth C; Sane, Rucha S; Buckley, Donna J; Buckley, Arthur R; Desai, Pankaj B (2004. ) Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital.Journal of clinical pharmacology, , 44 (11 ) ,1273-81 More Information

Einhaus, Charity M; Retzinger, Andrew C; Perrotta, Andre O; Dentler, Michael D; Jakate, Abhijeet S; Desai, Pankaj B; Retzinger, Gregory S (2004. ) Fibrinogen-coated droplets of olive oil for delivery of docetaxel to a fibrin(ogen)-rich ascites form of a murine mammary tumor.Clinical cancer research : an official journal of the American Association for Cancer Research, , 10 (20 ) ,7001-10 More Information

Nallani, Srikanth C; Goodwin, Bryan; Buckley, Arthur R; Buckley, Donna J; Desai, Pankaj B (2004. ) Differences in the induction of cytochrome P450 3A4 by taxane anticancer drugs, docetaxel and paclitaxel, assessed employing primary human hepatocytes.Cancer chemotherapy and pharmacology, , 54 (3 ) ,219-29 More Information

Nallani, Srikanth C; Glauser, Tracy A; Hariparsad, Niresh; Setchell, Kenneth; Buckley, Donna J; Buckley, Arthur R; Desai, Pankaj B (2003. ) Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate.Epilepsia, , 44 (12 ) ,1521-8 More Information

Jakate, Abhijeet S; Einhaus, Charity M; DeAnglis, Ashley P; Retzinger, Gregory S; Desai, Pankaj B (2003. ) Preparation, characterization, and preliminary application of fibrinogen-coated olive oil droplets for the targeted delivery of docetaxel to solid malignancies. Cancer research, , 63 (21 ) ,7314-20

Nallani, Srikanth C; Goodwin, Bryan; Maglich, Jodi M; Buckley, Donna J; Buckley, Arthur R; Desai, Pankaj B (2003. ) Induction of cytochrome P450 3A by paclitaxel in mice: pivotal role of the nuclear xenobiotic receptor, pregnane X receptor.Drug metabolism and disposition: the biological fate of chemicals, , 31 (5 ) ,681-4 More Information

Setchell, Kenneth D R; Brown, Nadine Maynard; Desai, Pankaj B; Zimmer-Nechimias, Linda; Wolfe, Brian; Jakate, Abhijeet S; Creutzinger, Vivian; Heubi, James E (2003. ) Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes.The Journal of nutrition, , 133 (4 ) ,1027-35 More Information

Roy-Chaudhury, Prabir; Kelly, Burnett S; Zhang, Jianhua; Narayana, Ashwath; Desai, Pankaj; Melham, Murad; Duncan, Heather; Heffelfinger, Sue C (2003. ) Hemodialysis vascular access dysfunction: from pathophysiology to novel therapies.Blood purification, , 21 (1 ) ,99-110 More Information

Desai, Pankaj B; Nallani, Srikanth C; Sane, Rucha S; Moore, Linda B; Goodwin, Bryan J; Buckley, Donna J; Buckley, Arthur R (2002. ) Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen.Drug metabolism and disposition: the biological fate of chemicals, , 30 (5 ) ,608-12 More Information

Roy-Chaudhury, Prabir; Kelly, Burnett S; Narayana, Ashwath; Desai, Pankaj; Melhem, Murad; Munda, Rino; Duncan, Heather; Heffelfinger, Sue C (2002. ) Hemodialysis vascular access dysfunction from basic biology to clinical intervention.Advances in renal replacement therapy, , 9 (2 ) ,74-84 More Information

Genter, Mary Beth; Apparaju, Sandhya; Desai, Pankaj B (2002. ) Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin.Journal of biochemical and molecular toxicology, , 16 (3 ) ,128-34 More Information

Stevens, Ruth E; Konsil, Julraht; Verrill, Sonya S; Roy, Partha; Desai, Pankaj B; Upmalis, David H; Cone, Frederick L (2002. ) Bioavailability study of a 1200 mg miconazole nitrate vaginal ovule in healthy female adults.Journal of clinical pharmacology, , 42 (1 ) ,52-60 More Information

Academic - UC College of Pharmacy
Wherry Hall, Room 210
Phone: 513-558-3870
Pankaj.Desai@uc.edu

Research - Desai's Lab
231 Albert Sabin Way
Cincinnati  Ohio, 45229
Phone: 513-558-0723