Jiajie Diao, PhD

Jiajie Diao, PhD

Associate Professor

Vontz Center for Molecular Studies
3125 Eden Avenue
ML 0521
Cincinnati, Ohio 45267
Phone 513-558-0234
Email jiajie.diao@uc.edu

Education

Doctoral Degree: University of Illinois Urbana-Champaign, (Physics)

Post Doctoral Fellowship: Stanford University & HHMI

Research and Practice Interests

Our group has an interest in Membrane Biophysics (Single-vesicle study of SNARE-mediated membrane fusion; Single-molecule analysis of protein conformational change in membrane environment (membrane property change induced by protein) and Nanotechnology (nanoparticle structures for biomedical detection).

Positions and Work Experience

- Our group has an interest in Membrane Biophysics (Single-vesicle study of SNARE-mediated membrane fusion; Single-molecule analysis of protein conformational change in membrane environment (membrane property change induced by protein) and Nanotechnology (nanoparticle structures for biomedical detection).,

Research Support

Grant: #R35GM128837 Investigators:Diao, Jiajie 08-01-2018 -07-31-2023 National Institute of General Medical Sciences SNARE-mediated membrane fusion involved in autophagosome biogenesis Role:PI $364,923.00 Active Level:Federal

Grant: #16661 Investigators:Diao, Jiajie; Seroogy, Kim 11-01-2018 -04-30-2020 Michael J. Fox Foundation for Parkinson's Research Chaperones of alpha-synuclein for membrane fusion involved in synaptic transmission Role:PI $99,081.00 Awarded Level:Private Non-Profit

Grant: #R21AG061600 Investigators:Diao, Jiajie 09-30-2019 -06-30-2021 National Institute on Aging Single-molecule study of alpha-synuclein Role:PI $200,625.00 Awarded Level:Federal

Grant: #201587 / R01NS113960 Investigators:Diao, Jiajie 06-01-2020 -05-31-2025 Joan & Sanford I. Weill Medical College of Cornell University The impact of synaptic vesicle-binding of alpha-synuclein on neuron function and neuropathology Role:PI $29,660.00 Awarded Level:Institution of Higher Education

Grant: #R01NS121077 Investigators:Diao, Jiajie 04-15-2021 -03-31-2026 National Institute of Neurological Disorders and Stroke The role of VAMP2 in alpha-synuclein function and pathology Role:PI $354,241.00 Awarded Level:Federal

Publications

Peer Reviewed Publications

Huang, Huaiyi; Yang, Liang; Zhang, Pingyu; Qiu, Kangqiang; Huang, Juanjuan; Chen, Yu; Diao, JiaJie; Liu, Jiankang; Ji, Liangnian; Long, Jiangang; Chao, Hui (2016. ) Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes.Biomaterials, , 83 ,321-31 More Information

Hu, Rui; Diao, Jiajie; Li, Ji; Tang, Zhipeng; Li, Xiaoqing; Leitz, Jeremy; Long, Jiangang; Liu, Jiankang; Yu, Dapeng; Zhao, Qing (2016. ) Intrinsic and membrane-facilitated alpha-synuclein oligomerization revealed by label-free detection through solid-state nanopores.Scientific reports, , 6 ,20776 More Information

Diao, Jiajie; Grob, Patricia; Cipriano, Daniel J; Kyoung, Minjoung; Zhang, Yunxiang; Shah, Sachi; Nguyen, Amie; Padolina, Mark; Srivastava, Ankita; Vrljic, Marija; Shah, Ankita; Nogales, Eva; Chu, Steven; Brunger, Axel T (2015. ) Correction: Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.eLife, , 4 ,e12289 More Information

Zhou, Qiangjun; Lai, Ying; Bacaj, Taulant; Zhao, Minglei; Lyubimov, Artem Y; Uervirojnangkoorn, Monarin; Zeldin, Oliver B; Brewster, Aaron S; Sauter, Nicholas K; Cohen, Aina E; Soltis, S Michael; Alonso-Mori, Roberto; Chollet, Matthieu; Lemke, Henrik T; Pfuetzner, Richard A; Choi, Ucheor B; Weis, William I; Diao, Jiajie; Südhof, Thomas C; Brunger, Axel T (2015. ) Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.Nature, , 525 (7567 ) ,62-7 More Information

Diao, Jiajie; Liu, Rong; Rong, Yueguang; Zhao, Minglei; Zhang, Jing; Lai, Ying; Zhou, Qiangjun; Wilz, Livia M; Li, Jianxu; Vivona, Sandro; Pfuetzner, Richard A; Brunger, Axel T; Zhong, Qing (2015. ) ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.Nature, , 520 (7548 ) ,563-6 More Information

Lai, Ying; Zhao, Lin; Bu, Bing; Lou, Xiaochu; Li, Dechang; Ji, Baohua; Liu, Jiankang; Diao, Jiajie; Shin, Yeon-Kyun (2015. ) Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion.Physical biology, , 12 (2 ) ,025003 More Information

Zhang, Yunxiang; Diao, Jiajie; Colbert, Karen N; Lai, Ying; Pfuetzner, Richard A; Padolina, Mark S; Vivona, Sandro; Ressl, Susanne; Cipriano, Daniel J; Choi, Ucheor B; Shah, Niket; Weis, William I; Brunger, Axel T (2015. ) Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexin.The Journal of biological chemistry, , 290 (16 ) ,10518-34 More Information

Lai, Ying; Lou, Xiaochu; Diao, Jiajie; Shin, Yeon-Kyun (2015. ) Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening.Scientific reports, , 5 ,9267 More Information

Brunger, Axel T; Cipriano, Daniel J; Diao, Jiajie (2015. ) Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins.Critical reviews in biochemistry and molecular biology, , 50 (3 ) ,231-41 More Information

Lai, Ying; Diao, Jiajie; Cipriano, Daniel J; Zhang, Yunxiang; Pfuetzner, Richard A; Padolina, Mark S; Brunger, Axel T (2014. ) Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms. eLife, , 3 ,e03756

Lai, Ying; Kim, Sunae; Varkey, Jobin; Lou, Xiaochu; Song, Jae-Kyun; Diao, Jiajie; Langen, Ralf; Shin, Yeon-Kyun (2014. ) Nonaggregated alpha-synuclein influences SNARE-dependent vesicle docking via membrane binding.Biochemistry, , 53 (24 ) ,3889-96 More Information

Diao, Jiajie; Cipriano, Daniel J; Zhao, Minglei; Zhang, Yunxiang; Shah, Sachi; Padolina, Mark S; Pfuetzner, Richard A; Brunger, Axel T (2013. ) Complexin-1 enhances the on-rate of vesicle docking via simultaneous SNARE and membrane interactions.Journal of the American Chemical Society, , 135 (41 ) ,15274-7 More Information

Diao, Jiajie; Zhao, Minglei; Zhang, Yunxiang; Kyoung, Minjoung; Brunger, Axel T (2013. ) Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.BioEssays : news and reviews in molecular, cellular and developmental biology, , 35 (7 ) ,658-65 More Information

Burré, Jacqueline; Vivona, Sandro; Diao, Jiajie; Sharma, Manu; Brunger, Axel T; Südhof, Thomas C (2013. ) Properties of native brain alpha-synuclein.Nature, , 498 (7453 ) ,E4-6; discussion E6-7 More Information

Diao, Jiajie; Burré, Jacqueline; Vivona, Sandro; Cipriano, Daniel J; Sharma, Manu; Kyoung, Minjoung; Südhof, Thomas C; Brunger, Axel T (2013. ) Native alpha-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2.eLife, , 2 ,e00592 More Information

Lai, Ying; Diao, Jiajie; Liu, Yanxin; Ishitsuka, Yuji; Su, Zengliu; Schulten, Klaus; Ha, Taekjip; Shin, Yeon-Kyun (2013. ) Fusion pore formation and expansion induced by Ca2+ and synaptotagmin 1.Proceedings of the National Academy of Sciences of the United States of America, , 110 (4 ) ,1333-8 More Information

Kyoung, Minjoung; Zhang, Yunxiang; Diao, Jiajie; Chu, Steven; Brunger, Axel T (2013. ) Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system.Nature protocols, , 8 (1 ) ,1-16 More Information

Diao, Jiajie; Ishitsuka, Yuji; Lee, Hanki; Joo, Chirlmin; Su, Zengliu; Syed, Salman; Shin, Yeon-Kyun; Yoon, Tae-Young; Ha, Taekjip (2012. ) A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins. Nature protocols, , 7 (5 ) ,921-34

Diao, Jiajie; Ishitsuka, Yuji; Bae, Woo-Ri (2011. ) Single-molecule FRET study of SNARE-mediated membrane fusion.Bioscience reports, , 31 (6 ) ,457-63 More Information

Kyoung, Minjoung; Srivastava, Ankita; Zhang, Yunxiang; Diao, Jiajie; Vrljic, Marija; Grob, Patricia; Nogales, Eva; Chu, Steven; Brunger, Axel T (2011. ) In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America, , 108 (29 ) ,E304-13 More Information

Diao, Jiajie; Su, Zengliu; Ishitsuka, Yuji; Lu, Bin; Lee, Kyung Suk; Lai, Ying; Shin, Yeon-Kyun; Ha, Taekjip (2010. ) A single-vesicle content mixing assay for SNARE-mediated membrane fusion.Nature communications, , 1 ,54 More Information

Diao, Jiajie; Su, Zengliu; Lu, Xiaobing; Yoon, Tae-Young; Shin, Yeon-Kyun; Ha, Taekjip (2010. ) Single-Vesicle Fusion Assay Reveals Munc18-1 Binding to the SNARE Core Is Sufficient for Stimulating Membrane Fusion.ACS chemical neuroscience, , 1 (3 ) ,168-174 More Information

Diao, Jiajie; Yoon, Tae-Young; Su, Zengliu; Shin, Yeon-Kyun; Ha, Taekjip (2009. ) C2AB: a molecular glue for lipid vesicles with a negatively charged surface.Langmuir : the ACS journal of surfaces and colloids, , 25 (13 ) ,7177-80 More Information

Yoon, Tae-Young; Lu, Xiaobing; Diao, Jiajie; Lee, Soo-Min; Ha, Taekjip; Shin, Yeon-Kyun (2008. ) Complexin and Ca2+ stimulate SNARE-mediated membrane fusion.Nature structural & molecular biology, , 15 (7 ) ,707-13 More Information

Song, Chun-Xiao; Diao, Jiajie; Brunger, Axel T; Quake, Stephen R (2016. ) Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation.Proceedings of the National Academy of Sciences of the United States of America, , 113 (16 ) ,4338-43 More Information

Diao, Jiajie; Grob, Patricia; Cipriano, Daniel J; Kyoung, Minjoung; Zhang, Yunxiang; Shah, Sachi; Nguyen, Amie; Padolina, Mark; Srivastava, Ankita; Vrljic, Marija; Shah, Ankita; Nogales, Eva; Chu, Steven; Brunger, Axel T (2012. ) Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion.eLife, , 1 ,e00109 More Information

Malmersjö, Seth; Di Palma, Serena; Diao, Jiajie; Lai, Ying; Pfuetzner, Richard A; Wang, Austin L; McMahon, Moira A; Hayer, Arnold; Porteus, Matthew; Bodenmiller, Bernd; Brunger, Axel T; Meyer, Tobias (2016. ) Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion.The EMBO journal, , More Information

Wang, Chuchu; Zhao, Chunyu; Li, Dan; Tian, Zhiqi; Lai, Ying; Diao, Jiajie; Liu, Cong (2016. ) Versatile Structures of α-Synuclein.Frontiers in molecular neuroscience, , 9 ,48 More Information

Qing, Ying; Tian, Zhiqi; Bi, Ying; Wang, Yongyao; Long, Jiangang; Song, Chun-Xiao; Diao, Jiajie (2017. ) Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine.BioEssays : news and reviews in molecular, cellular and developmental biology, , 39 (5 ) , More Information

Wang, Yongyao; Li, Linsen; Hou, Chen; Lai, Ying; Long, Jiangang; Liu, Jiankang; Zhong, Qing; Diao, Jiajie (2016. ) SNARE-mediated membrane fusion in autophagy.Seminars in cell & developmental biology, , 60 ,97-104 More Information

Gong, Jihong; Lai, Ying; Li, Xiaohong; Wang, Mengxian; Leitz, Jeremy; Hu, Yachong; Zhang, Yunxiang; Choi, Ucheor B; Cipriano, Daniel; Pfuetzner, Richard A; Südhof, Thomas C; Yang, Xiaofei; Brunger, Axel T; Diao, Jiajie (2016. ) C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.Proceedings of the National Academy of Sciences of the United States of America, , 113 (47 ) ,E7590-E7599 More Information

Lai, Ying; Choi, Ucheor B; Zhang, Yunxiang; Zhao, Minglei; Pfuetzner, Richard A; Wang, Austin L; Diao, Jiajie; Brunger, Axel T (2016. ) N-terminal domain of complexin independently activates calcium-triggered fusion.Proceedings of the National Academy of Sciences of the United States of America, , 113 (32 ) ,E4698-707 More Information

Z. Tian, Y. Hu, J. Long, J. Liu, J. Diao (2016. ) Single-molecule biophysical studies of neurotransmitter release.Prog. Biochem. Biophys, , 43 ,946 More Information

X. Li, R. Hu, J. Li, X. Tong, J.J. Diao, D. Yu, Q. Zhao (2016. ) Non-sticky translocation of bio-molecules through Tween 20-coated solid-state nanopores in a wide pH range.Appl. Phys. Lett, , 109 ,143105 More Information

J. Diao, L. Li, Y. Lai, Q. Zhong (2017. ) In vitro reconstitution of autophagosome-lysosome fusion.Methods Enzymo, , 586 ,365-376 More Information

B. Bu, D. Li, J. Diao, B. Ji (2017. ) Mechanics of water pore formation in lipid membrane under electric field.Acta Mech. Sin, , 33 (2 ) ,23242 More Information

Y. Hu, Y. Lai, Y. Wang, M. Zhao, Y. Zhang, M. Crowe, Z. Tian, J. Long, J. Diao (2017. ) SNARE-reconstituted liposomes as controllable zeptoliter nanoreactors for macromolecules.Adv. Biosys, , 1 , More Information

S.C. Shen, W. Liu, J.J. Diao (2015. ) Nanoparticle wire structures for biophysical detections.Chin. Phys, , B 24 ,127308 More Information

L. Shao, J.J. Diao, Z. Tang, S. Liu, S.C. Shen, X. Rui, J. Liu, D. Yu, Q. Zhao (2014. ) Gold nanoparticle wires for sensing DNA and DNA/protein interactions.Nanoscale, , 6 ,4089 More Information

Song, Chun-Xiao; Yin, Senlin; Ma, Li; Wheeler, Amanda; Chen, Yu; Zhang, Yan; Liu, Bin; Xiong, Junjie; Zhang, Weihan; Hu, Jiankun; Zhou, Zongguang; Dong, Biao; Tian, Zhiqi; Jeffrey, Stefanie S; Chua, Mei-Sze; So, Samuel; Li, Weimin; Wei, Yuquan; Diao, Jiajie; Xie, Dan; Quake, Stephen R (2017. ) 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages.Cell research, , More Information

Bu, Bing; Tong, Xin; Li, Dechang; Hu, Yachong; He, Wangxiao; Zhao, Chunyu; Hu, Rui; Li, Xiaoqing; Shao, Yongping; Liu, Cong; Zhao, Qing; Ji, Baohua; Diao, Jiajie (2017. ) N-Terminal Acetylation Preserves α-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds.ACS chemical neuroscience, , More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2017. ) Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 8 (1 ) ,2099 More Information

Bhattacharjee, Anukana; Wang, Yongyao; Diao, Jiajie; Price, Carolyn M (2017. ) Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.Nucleic acids research, , 45 (21 ) ,12311-12324 More Information

Qiu, Kangqiang; Ke, Libing; Zhang, Xuepeng; Liu, Yukang; Rees, Thomas W; Ji, Liangnian; Diao, Jiajie; Chao, Hui (2018. ) Tracking mitochondrial pH fluctuation during cell apoptosis with two-photon phosphorescent iridium(iii) complexes.Chemical communications (Cambridge, England), , 54 (19 ) ,2421-2424 More Information

Bu, Bing; Crowe, Michael; Diao, Jiajie; Ji, Baohua; Li, Dechang (2018. ) Cholesterol suppresses membrane leakage by decreasing water penetrability.Soft matter, , 14 (25 ) ,5277-5282 More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2018. ) Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 9 (1 ) ,670 More Information

Hu, Yachong; Tian, Zhiqi; Diao, Jiajie (2019. ) Single-Molecule Fluorescence Measurement of SNARE-Mediated Vesicle Fusion.Methods in molecular biology (Clifton, N.J.), , 1860 ,335-344 More Information

Khamo, John S; Krishnamurthy, Vishnu V; Chen, Qixin; Diao, Jiajie; Zhang, Kai (2018. ) Optogenetic Delineation of Receptor Tyrosine Kinase Subcircuits in PC12 Cell Differentiation.Cell chemical biology, , More Information

Chen, Qixin; Jin, Chengzhi; Shao, Xintian; Guan, Ruilin; Tian, Zhiqi; Wang, Chenran; Liu, Fei; Ling, Peixue; Guan, Jun-Lin; Ji, Liangnian; Wang, Fengshan; Chao, Hui; Diao, Jiajie (2018. ) Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore.Small (Weinheim an der Bergstrasse, Germany), , 14 (41 ) ,e1802166 More Information

Leikina, Evgenia; Gamage, Dilani G; Prasad, Vikram; Goykhberg, Joanna; Crowe, Michael; Diao, Jiajie; Kozlov, Michael M; Chernomordik, Leonid V; Millay, Douglas P (2018. ) Myomaker and Myomerger Work Independently to Control Distinct Steps of Membrane Remodeling during Myoblast Fusion.Developmental cell, , 46 (6 ) ,767-780.e7 More Information

Feng, Xuyang; Hsu, Shih-Jui; Bhattacharjee, Anukana; Wang, Yongyao; Diao, Jiajie; Price, Carolyn M (2018. ) CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.Nature communications, , 9 (1 ) ,2827 More Information

Tian, Zhiqi; Gong, Jihong; Crowe, Michael; Lei, Ming; Li, Dechang; Ji, Baohua; Diao, Jiajie (2019. ) Biochemical studies of membrane fusion at the single-particle level.Progress in lipid research, , 73 ,92-100 More Information

Cai, Bin; Yu, Luning; Sharum, Savanna R; Zhang, Kai; Diao, Jiajie (2019. ) Single-vesicle measurement of protein-induced membrane tethering.Colloids and surfaces. B, Biointerfaces, , 177 ,267-273 More Information

Ma, Dong-Fei; Xu, Chun-Hua; Hou, Wen-Qing; Zhao, Chun-Yu; Ma, Jian-Bing; Huang, Xing-Yuan; Jia, Qi; Ma, Lu; Diao, Jiajie; Liu, Cong; Li, Ming; Lu, Ying (2019. ) Detecting Single-Molecule Dynamics on Lipid Membranes with Quenchers-in-a-Liposome FRET.Angewandte Chemie (International ed. in English), , More Information

Diao, J; Li, L; Lai, Y; Zhong, Q (2017. ) In Vitro Reconstitution of Autophagosome-Lysosome Fusion.Methods in enzymology, , 587 ,365-376 More Information

Brose, Nils; Brunger, Axel; Cafiso, David; Chapman, Edwin R; Diao, Jiajie; Hughson, Frederick M; Jackson, Meyer B; Jahn, Reinhard; Lindau, Manfred; Ma, Cong; Rizo, Josep; Shin, Yeon-Kyun; Söllner, Thomas H; Tamm, Lukas; Yoon, Tae-Young; Zhang, Yongli (2019. ) Synaptic vesicle fusion: today and beyond.Nature structural & molecular biology, , 26 (8 ) ,663-668 More Information

Jiang, Xi; Hu, Chao; Ferchen, Kyle; Nie, Ji; Cui, Xiaolong; Chen, Chih-Hong; Cheng, Liting; Zuo, Zhixiang; Seibel, William; He, Chunjiang; Tang, Yixuan; Skibbe, Jennifer R; Wunderlich, Mark; Reinhold, William C; Dong, Lei; Shen, Chao; Arnovitz, Stephen; Ulrich, Bryan; Lu, Jiuwei; Weng, Hengyou; Su, Rui; Huang, Huilin; Wang, Yungui; Li, Chenying; Qin, Xi; Mulloy, James C; Zheng, Yi; Diao, Jiajie; Jin, Jie; Li, Chong; Liu, Paul P; He, Chuan; Chen, Yuan; Chen, Jianjun (2017. ) Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia.Nature communications, , 8 (1 ) ,2099 More Information

Wang, Zichen; Fan, Huaxun; Hu, Xiao; Khamo, John; Diao, Jiajie; Zhang, Kai; Pogorelov, Taras V (2019. ) Coaction of Electrostatic and Hydrophobic Interactions: Dynamic Constraints on Disordered TrkA Juxtamembrane Domain.The journal of physical chemistry. B, , 123 (50 ) ,10709-10717 More Information

Bhattacharjee, Anukana; Wang, Yongyao; Diao, Jiajie; Price, Carolyn M (2017. ) Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST.Nucleic acids research, , 45 (21 ) ,12311-12324 More Information

Wang, Chuchu; Tu, Jia; Zhang, Shengnan; Cai, Bin; Liu, Zhenying; Hou, Shouqiao; Zhong, Qinglu; Hu, Xiao; Liu, Wenbin; Li, Guohui; Liu, Zhijun; He, Lin; Diao, Jiajie; Zhu, Zheng-Jiang; Li, Dan; Liu, Cong (2020. ) Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly.Nature communications, , 11 (1 ) ,1531 More Information

Chen, Qixin; Shao, Xintian; Hao, Mingang; Fang, Hongbao; Guan, Ruilin; Tian, Zhiqi; Li, Miaoling; Wang, Chenran; Ji, Liangnian; Chao, Hui; Guan, Jun-Lin; Diao, Jiajie (2020. ) Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy.Biomaterials, , 250 ,120059 More Information

Sun, Jian; Du, Ke; Diao, Jiajie; Cai, Xuetong; Feng, Fude; Wang, Shu (2020. ) GSH and H2O2 Co-Activatable Mitochondria-Targeted Photodynamic Therapy under Normoxia and Hypoxia.Angewandte Chemie (International ed. in English), , More Information

Qiu, Kangqiang; Du, Yang; Liu, Jiyan; Guan, Jun-Lin; Chao, Hui; Diao, Jiajie (2020. ) Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles.Theranostics, , 10 (13 ) ,6072-6081 More Information

Li, Miaoling; Oh, Teak-Jung; Fan, Huaxun; Diao, Jiajie; Zhang, Kai (2020. ) Syntaxin Clustering and Optogenetic Control for Synaptic Membrane Fusion.Journal of molecular biology, , More Information

Liu, Liu-Yi; Fang, Hongbao; Chen, Qixin; Chan, Michael Ho-Yeung; Ng, Maggie; Wang, Kang-Nan Wang; Liu, Wenting; Tian, Zhiqi; Diao, Jiajie; Mao, Zong-Wan; Yam, Vivian W W (2020. ) Multiple-Color Platinum Complex with Super-Large Stokes Shift for Super-Resolution Imaging of Autolysosome Escape.Angewandte Chemie (International ed. in English), , More Information

Hu, Yachong; Lai, Ying; Wang, Yongyao; Zhao, Minglei; Zhang, Yunxiang; Crowe, Michael; Tian, Zhiqi; Long, Jiangang; Diao, Jiajie (2017. ) SNARE-Reconstituted Liposomes as Controllable Zeptoliter Nanoreactors for Macromolecules.Advanced biosystems, , 1 (1-2 ) ,e1600018 More Information

Zheng, Xiaoqiang; Yan, Jin; You, Weiming; Li, Fanni; Diao, Jiajie; He, Wangxiao; Yao, Yu (2021. ) De Novo Nano-Erythrocyte Structurally Braced by Biomimetic Au(I)-peptide Skeleton for MDM2/MDMX Predation toward Augmented Pulmonary Adenocarcinoma Immunotherapy.Small (Weinheim an der Bergstrasse, Germany), , e2100394 More Information

Lerner, Eitan; Barth, Anders; Hendrix, Jelle; Ambrose, Benjamin; Birkedal, Victoria; Blanchard, Scott C; Börner, Richard; Sung Chung, Hoi; Cordes, Thorben; Craggs, Timothy D; Deniz, Ashok A; Diao, Jiajie; Fei, Jingyi; Gonzalez, Ruben L; Gopich, Irina V; Ha, Taekjip; Hanke, Christian A; Haran, Gilad; Hatzakis, Nikos S; Hohng, Sungchul; Hong, Seok-Cheol; Hugel, Thorsten; Ingargiola, Antonino; Joo, Chirlmin; Kapanidis, Achillefs N; Kim, Harold D; Laurence, Ted; Lee, Nam Ki; Lee, Tae-Hee; Lemke, Edward A; Margeat, Emmanuel; Michaelis, Jens; Michalet, Xavier; Myong, Sua; Nettels, Daniel; Peulen, Thomas-Otavio; Ploetz, Evelyn; Razvag, Yair; Robb, Nicole C; Schuler, Benjamin; Soleimaninejad, Hamid; Tang, Chun; Vafabakhsh, Reza; Lamb, Don C; Seidel, Claus Am; Weiss, Shimon (2021. ) FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices.eLife, , 10 , More Information

Tao, Youqi; Xie, Jingfei; Zhong, Qinglu; Wang, Yongyao; Zhang, Shengnan; Luo, Feng; Wen, Fengcai; Xie, Jingjing; Zhao, Jiawei; Sun, Xiaoou; Long, Houfang; Ma, Junfeng; Zhang, Qian; Long, Jiangang; Fang, Xianyang; Lu, Ying; Li, Dan; Li, Ming; Zhu, Jidong; Sun, Bo; Li, Guohui; Diao, Jiajie; Liu, Cong (2021. ) A novel partially-open state of SHP2 points to a "multiple gear" regulation mechanism.The Journal of biological chemistry, , 100538 More Information

Fang, Hongbao; Geng, Shanshan; Hao, Mingang; Chen, Qixin; Liu, Minglun; Liu, Chunyan; Tian, Zhiqi; Wang, Chengjun; Takebe, Takanori; Guan, Jun-Lin; Chen, Yuncong; Guo, Zijian; He, Weijiang; Diao, Jiajie (2021. ) Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells.Nature communications, , 12 (1 ) ,109 More Information

Chen, Qixin; Fang, Hongbao; Shao, Xintian; Tian, Zhiqi; Geng, Shanshan; Zhang, Yuming; Fan, Huaxun; Xiang, Pan; Zhang, Jie; Tian, Xiaohe; Zhang, Kai; He, Weijiang; Guo, Zijian; Diao, Jiajie (2020. ) A dual-labeling probe to track functional mitochondria-lysosome interactions in live cells.Nature communications, , 11 (1 ) ,6290 More Information

Wu, Kai; Li, Dechang; Xiu, Peng; Ji, Baohua; Diao, Jiajie (2020. ) O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect.Physical biology, , 18 (1 ) ,016002 More Information

Li, Miaoling; Oh, Teak-Jung; Fan, Huaxun; Diao, Jiajie; Zhang, Kai (2020. ) Corrigendum to "Syntaxin Clustering and Optogenetic Control for Synaptic Membrane Fusion" [J. Mol. Biol. 432 (2020) 4773-4782].Journal of molecular biology, , 432 (23 ) ,6228-6229 More Information

Zou, Weiwei; Chen, Qixin; Slone, Jesse; Yang, Li; Lou, Xiaoting; Diao, Jiajie; Huang, Taosheng (2021. ) Nanoscopic quantification of sub-mitochondrial morphology, mitophagy and mitochondrial dynamics in living cells derived from patients with mitochondrial diseases.Journal of nanobiotechnology, , 19 (1 ) ,136 More Information

Contact Information

Academic - Vontz Center for Molecular Studies
3125 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 513-558-0234
jiajie.diao@uc.edu