Wa Du

Bachelor's Degree: China Medical University ShenYang, LiaoNing, China, 2001 (Medicine)

Master Degree: China Medical University ShenYang, LiaoNing, China, 2004 (Pharmacology)

Doctoral Degree: Kanazawa University Kanazawa, Ishikawa, Japan, 2010 (Physiology)

The main focuses of my research are 1) endothelial cell and immune cell communication in the tumor microenvironment; 2) the protective role of endothelial TFEB in chemotherapy; and 3) endothelial dysfunction in cardiovascular disease.

10-2010 -10-2015 Research Fellow, Baylor College of Medicine, Houston, TX

10-2020 -11-2023 Research Scientist, University of Cincinnati, Cincinnati, Ohio

Grant: #1R01HL171497-01A1 Investigators:Becker, Richard; Du, Wa; Fan, Yanbo; Wang, Yi-Gang -06-30-2029 National Heart, Lung and Blood Institute Alleviation of chemotherapy-induced cardiovascular toxicity Role:Collaborator 0.00 Hold Level:Federal

Peer Reviewed Publications

Wa Du, Lu Ren, Milton H Hamblin, Yanbo Fan (2021. ) Endothelial Cell Glucose Metabolism and Angiogenesis.Biomedicines, , 9 (2 ) ,147 More Information

Taylor J Chen, Wa Du, Jacob J Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R Rabin, H Daniel Lacorazza (2021. ) Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia.Oncotarget, , 12 (18 ) ,1787 More Information

Haocheng Lu, Wa Du, Lu Ren, Milton H Hamblin, Richard C Becker, Y Eugene Chen, Yanbo Fan (2021. ) Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms.Journal of the American Heart Association, , 10 (24 ) ,e023601 More Information

Zhongcheng Shi, Yuko Mori-Akiyama, Wa Du, Robert Fultz, Yanling Zhao, Wenly Ruan, Susan Venable, Melinda A Engevik, James Versalovic (2022. ) Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice.Cellular and Molecular Gastroenterology and Hepatology, , 13 (3 ) ,717 More Information

Andrew Henry Lewis, Cory Seth Bridges, David Neal Moorshead, Taylor J Chen, Wa Du, Barry Zorman, Pavel Sumazin, Monica Puppi, H Daniel Lacorazza (2022. ) Krüppel-like Factor 4 Supports the Expansion of Leukemia Stem Cells in MLL-AF9-driven Acute Myeloid Leukemia.Stem Cells, , 40 (8 ) ,736 More Information

Lu Ren, Wa Du, Dan Song, Haocheng Lu, Milton H Hamblin, Chenran Wang, Chunying Du, Guo-Chang Fan, Richard C Becker, Yanbo Fan (2022. ) Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice.iScience, , 26 (1 ) ,105769 More Information

Hongyan Zhao, Peng Wang, Xiaohong Wang, Wa Du, Hui-Hui Yang, Yueying Liu, Shu-Nan Cui, Wei Huang, Tianqing Peng, Jing Chen, Chen Gao, Yigang Wang, Sakthivel Sadayappan, Chengen Ma, Yanbo Fan, Chunting Wang, Guo-Chang Fan (2023. ) Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway.Cardiovascular Research, , 119 (10 ) ,1981 More Information

Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang (2023. ) Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway.Cardiovascular research, , 119 (10 ) ,1981-1996 More Information

Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo (2023. ) Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice.iScience, , 26 (1 ) ,105769 More Information

Shi, Zhongcheng; Mori-Akiyama, Yuko; Du, Wa; Fultz, Robert; Zhao, Yanling; Ruan, Wenly; Venable, Susan; Engevik, Melinda A; Versalovic, James (2022. ) Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice.Cellular and molecular gastroenterology and hepatology, , 13 (3 ) ,717-737 More Information

Lu, Haocheng; Du, Wa; Ren, Lu; Hamblin, Milton H; Becker, Richard C; Chen, Y Eugene; Fan, Yanbo (2021. ) Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms.Journal of the American Heart Association, , 10 (24 ) ,e023601 More Information

Du, Wa; Ren, Lu; Hamblin, Milton H; Fan, Yanbo (2021. ) Endothelial Cell Glucose Metabolism and Angiogenesis.Biomedicines, , 9 (2 ) , More Information

Thuy L Phung, Wa Du, Qi Xue, Sriram Ayyaswamy, Damien Gerald, Zeus Antonello, Sokha Nhek, Carole A Perruzzi, Isabel Acevedo, Rajesh Ramanna-Valmiki, Paul Rodriguez-Waitkus, Ladan Enayati, Marcelo L Hochman, Dina Lev, Sandaruwan Geeganage, Laura E Benjamin (2015. ) Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.Cancer Research, , 75 (1 ) ,40 More Information

Hong Cui, Yasuo Okamoto, Kazuaki Yoshioka, Wa Du, Noriko Takuwa, Wei Zhang, Masahide Asano, Toshishige Shibamoto, Yoh Takuwa (2013. ) Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice.Journal of Allergy and Clinical Immunology, , 132 (5 ) ,1205 More Information

Wa Du, Damien Gerald, Carole A Perruzzi, Paul Rodriguez-Waitkus, Ladan Enayati, Bhuvaneswari Krishnan, Joseph Edmonds, Marcelo L Hochman, Dina C Lev, Thuy L Phung (2013. ) Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin.Lab Investigation, , 93 (10 ) ,1115 More Information

Kazuaki Yoshioka, Kotaro Yoshida, Hong Cui, Tomohiko Wakayama, Noriko Takuwa, Yasuo Okamoto, Wa Du, Xun Qi, Ken Asanuma, Kazushi Sugihara, Sho Aki, Hidekazu Miyazawa, Kuntal Biswas, Chisa Nagakura, Masaya Ueno, Shoichi Iseki, Robert J Schwartz, Hiroshi Okamoto, Takehiko Sasaki, Osamu Matsui, Masahide Asano, Ralf H Adams, Nobuyuki Takakura, Yoh Takuwa (2012. ) Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.Nature Medicine, , 18 (10 ) ,1560 More Information

Noriko Takuwa, Wa Du, Erika Kaneko, Yasuo Okamoto, Kazuaki Yoshioka, Yoh Takuwa (2011. ) Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde .American Journal of Cancer Research, , 1 (4 ) ,460

Yoh Takuwa, Wa Du, Xun Qi, Yasuo Okamoto, Noriko Takuwa, Kazuaki Yoshioka (2010. ) Roles of sphingosine-1-phosphate signaling in angiogenesis.World Journal of Biological Chemistry, , 1 (10 ) ,298 More Information

Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa (2010. ) Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice.European Journal of Pharmacology, , 634 (1-3 ) ,121 More Information

Noriko Takuwa, Sei-Ichiro Ohkura, Shin-Ichiro Takashima, Keisuke Ohtani, Yasuo Okamoto, Tamotsu Tanaka, Kaoru Hirano, Soichiro Usui, Fei Wang, Wa Du, Kazuaki Yoshioka, Yoshiko Banno, Motoko Sasaki, Ikuyo Ichi, Miwa Okamura, Naotoshi Sugimoto, Kiyomi Mizugishi, Yasuni Nakanuma, Isao Ishii, Masayuki Takamura, Shuichi Kaneko, Shosuke Kojo, Kiyoshi Satouchi, Kunitoshi Mitumori, Jerold Chun, Yoh Takuwa (2010. ) S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.Cardiovascular Research, , 85 (3 ) ,484 More Information

Wa Du, Noriko Takuwa, Kazuaki Yoshioka, Yasuo Okamoto, Koichi Gonda, Kazushi Sugihara, Akiyoshi Fukamizu, Masahide Asano, Yoh Takuwa (2010. ) S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.Cancer Research, , 70 (2 ) ,772 More Information

Xiaohong Wang, Wa Du, Yutian Li, Hui-Hui Yang, Yu Zhang, Rubab Akbar, Hannah Morgan, Tianqing Peng, Jing Chen, Sakthivel Sadayappan, Yueh-Chiang Hu, Yanbo Fan, Wei Huang, and Guo-Chang Fan (2024. ) Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury.JCI Insights, , 9 (5 ) , More Information

Symposium

Wa Du, Wa Du (05-10-2023. ) Endothelial Transcription Factor EB Protects Against Doxorubicin-induced Endothelial Toxicity And Cardiac Dysfunction .Boston, MA. Conference. Level:International

Endothelial Transcription Factor EB Protects Against Doxorubicin-induced Endothelial Toxicity And Cardiac Dysfunction

Wa Du (05-12-2022. ) Genetic Ablation Of CCDC92 Protects Against Vascular Inflammation And Atherosclerosis .Seattle, Washington. Conference. Level:International

Genetic Ablation Of CCDC92 Protects Against Vascular Inflammation And Atherosclerosis